Ces1g

Summary

Gene Symbol: Ces1g
Description: carboxylesterase 1G
Alias: Ces-1, Ces1, Ses-1, liver carboxylesterase 1, ES-x, acyl-coenzyme A:cholesterol acyltransferase, carboxylesterase 1
Species: mouse

Top Publications

  1. doi Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes
    Kerry W S Ko
    Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Biochim Biophys Acta 1791:1133-43. 2009
  2. pmc Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis
    Jiesi Xu
    Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA
    Hepatology 59:1761-71. 2014
  3. doi OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice
    Dilek Iusuf
    Corresponding Author Alfred H Schinkel, Division of Molecular Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cancer Ther 13:492-503. 2014
  4. pmc Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation
    Andrew D Hoffmann
    Departments of Pediatrics, Pathology, and Human Genetics, The University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 10:e1004604. 2014
  5. doi Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling
    Wesam Bahitham
    Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta T6G 2S2, Canada Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada King Abdullah International Medical Research Center KAIMRC, Jeddah, Saudi Arabia
    Biochim Biophys Acta 1861:482-90. 2016
  6. doi Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia
    Ariel D Quiroga
    Department of Pediatrics, University of Alberta, Edmonton, Canada
    Hepatology 56:2188-98. 2012
  7. pmc Carboxylesterase1/Esterase-x regulates chylomicron production in mice
    Ariel D Quiroga
    Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 7:e49515. 2012
  8. ncbi Cloning and sequencing of a novel murine liver carboxylesterase cDNA
    P Ellinghaus
    Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat Munster, 48149 Munster, Germany
    Biochim Biophys Acta 1397:175-9. 1998
  9. ncbi Nonspecific esterase released from thymic macrophages accumulates in the apoptotic thymocytes: an indication for this enzyme participating in the clearance of apoptotic thymocytes
    Ji Ming Feng
    Department of Histology and Embryology, Peking University Health Science Center, Beijing, China
    Eur J Immunol 32:1386-92. 2002
  10. pmc Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    J Med Primatol 38:27-38. 2009

Scientific Experts

  • Alfred H Schinkel
  • Ji Ming Feng
  • Richard Lehner
  • Ariel D Quiroga
  • Wesam Bahitham
  • Jiesi Xu
  • Andrew D Hoffmann
  • Dilek Iusuf
  • Jihong Lian
  • Kerry W S Ko
  • Roger S Holmes
  • Hao Jie Zhu
  • Randal Nelson
  • Russell Watts
  • Vladimir V Kalinichenko
  • Wei Dong Chen
  • Yuanyuan Li
  • Anita van Esch
  • Xiaomeng Ren
  • Marion Ludwig
  • Joshua D Bosman
  • Xuemei Ge
  • Xinan Holly Yang
  • Ahmed Elbatsh
  • Ivan P Moskowitz
  • Fan Lin
  • Luciano Adorini
  • Ozanna Burnicka-Turek
  • Els Wagenaar
  • Kavita Jadhav
  • Evita van de Steeg
  • Steven A Vokes
  • Yanqiao Zhang
  • Martin van der Valk
  • Liya Yin
  • Yang Xu
  • Andrew P McMahon
  • Olaf van Tellingen
  • Jeffrey D Steimle
  • Lena Li
  • Randy Nelson
  • Harald Köfeler
  • Martin Trötzmüller
  • Spencer D Proctor
  • John S Markowitz
  • Laura A Cox
  • Yan Jiang
  • John L Vandeberg
  • David I Appel
  • Jeremy P Glenn
  • Bruce Erickson
  • P Ellinghaus
  • J Becker-Follmann
  • G Assmann
  • U Seedorf
  • E Bausch
  • G Scherer
  • A Gaa
  • O von Deimling
  • E Natt

Detail Information

Publications12

  1. doi Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes
    Kerry W S Ko
    Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Biochim Biophys Acta 1791:1133-43. 2009
    Mouse esterase-x/carboxylesterase 1 (Es-x/Ces1) is a close homolog of triacylglycerol hydrolase/carboxylesterase 3 (TGH/Ces3)...
  2. pmc Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis
    Jiesi Xu
    Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA
    Hepatology 59:1761-71. 2014
    ..Here we investigated the role of hepatic carboxylesterase 1 (CES1) in regulating both normal and FXR-controlled lipid homeostasis...
  3. doi OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice
    Dilek Iusuf
    Corresponding Author Alfred H Schinkel, Division of Molecular Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cancer Ther 13:492-503. 2014
    ..Interestingly, liver-specific humanized OATP1B1 and OATP1B3 transgenic mice had normalized hepatic expression of Ces1 genes...
  4. pmc Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation
    Andrew D Hoffmann
    Departments of Pediatrics, Pathology, and Human Genetics, The University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 10:e1004604. 2014
    ....
  5. doi Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling
    Wesam Bahitham
    Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta T6G 2S2, Canada Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada King Abdullah International Medical Research Center KAIMRC, Jeddah, Saudi Arabia
    Biochim Biophys Acta 1861:482-90. 2016
    b>Ces1g/Es-x deficiency in mice results in weight gain, insulin resistance, fatty liver and hyperlipidemia through upregulation of de novo lipogenesis and oversecretion of triacylglycerol (TG)-rich lipoproteins...
  6. doi Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia
    Ariel D Quiroga
    Department of Pediatrics, University of Alberta, Edmonton, Canada
    Hepatology 56:2188-98. 2012
    ..Here we show that carboxylesterase 1/esterase-x (Ces1/Es-x) plays a regulatory role in hepatic fat metabolism in the mouse...
  7. pmc Carboxylesterase1/Esterase-x regulates chylomicron production in mice
    Ariel D Quiroga
    Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 7:e49515. 2012
    ..Carboxylesterase1/esterase-x (Ces1/Es-x) deficient mice become obese, hyperlipidemic and develop hepatic steatosis even on standard chow diet...
  8. ncbi Cloning and sequencing of a novel murine liver carboxylesterase cDNA
    P Ellinghaus
    Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat Munster, 48149 Munster, Germany
    Biochim Biophys Acta 1397:175-9. 1998
    ..1 esterase. We further demonstrate that feeding mice with diets containing cholestyramine or sodium cholate increases mRNA-expression of ES-x in liver 2.5- to 3-fold...
  9. ncbi Nonspecific esterase released from thymic macrophages accumulates in the apoptotic thymocytes: an indication for this enzyme participating in the clearance of apoptotic thymocytes
    Ji Ming Feng
    Department of Histology and Embryology, Peking University Health Science Center, Beijing, China
    Eur J Immunol 32:1386-92. 2002
    ..Inhibition study showed that the inhibition of NSE delayed the MBT progressing to the late apoptotic phase. These results suggest that the NSE released from macrophages is involved in the clearance of apoptotic thymocytes...
  10. pmc Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    J Med Primatol 38:27-38. 2009
    ....
  11. doi Age- and sex-related expression and activity of carboxylesterase 1 and 2 in mouse and human liver
    Hao Jie Zhu
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, 73 Ashley Avenue, Charleston, SC 29425, USA
    Drug Metab Dispos 37:1819-25. 2009
    ..In this study, age- and sex-dependent expression and activity of CES1 and CES2 were investigated using both animal models and individual human liver s9 samples...
  12. ncbi High-resolution mapping of a linkage group on mouse chromosome 8 conserved on human chromosome 16Q
    J Becker-Follmann
    Institute of Human Genetics, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Mamm Genome 8:172-7. 1997
    ..The following locus order with distances in cM was obtained: (centromere)-Os-4.1-Mmp2-0.2-Ces1,Es1, Es22-1.2-Mt1,D8Mit15-2.2-Got2, D8Mit11-3.7-Es30-0.3-Es2, Es7-0.9-Ctra1,Lcat-0.3-Cdh1, Cadp, Nmor1, D8Mit12-0...