Ces1c

Summary

Gene Symbol: Ces1c
Description: carboxylesterase 1C
Alias: Ces-N, Ee-1, Ee1, Es-4, Es-N, Es1, Es4, EsN, PESN, carboxylesterase 1C, PES-N, esterase 1, liver carboxylesterase N, lung surfactant convertase
Species: mouse

Top Publications

  1. pmc Phospho-NSAIDs have enhanced efficacy in mice lacking plasma carboxylesterase: implications for their clinical pharmacology
    Chi C Wong
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, HSC, T 17 Room 080, Stony Brook, NY, 11794 8173, USA
    Pharm Res 32:1663-75. 2015
  2. pmc Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels
    Jiesi Xu
    Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, United States of America
    PLoS ONE 9:e109663. 2014
  3. ncbi Esterase-17 (ES-17): characterization and genetic location on chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of the house mouse (Mus musculus)
    J Otto
    Biochem Genet 21:37-48. 1983
  4. ncbi Polymorphism and linkage of glutathione reductase in Mus musculus
    E A Nichols
    Biochem Genet 13:323-9. 1975
  5. pmc Control of RhoA methylation by carboxylesterase I
    Ian Cushman
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 288:19177-83. 2013
  6. pmc Genetic mapping of ecotropic murine leukemia virus-inducing loci in six inbred strains
    C A Kozak
    J Exp Med 155:524-34. 1982
  7. ncbi Assignment of the gene for adenine phosphoribosyltransferase on the genetic map of mouse chromosome 8
    T B Nesterova
    Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Department, Novosibirsk
    Biochem Genet 25:563-8. 1987
  8. pmc The genetic control of two types of esterases in inbred strains of the mouse
    F H Ruddle
    Genetics 54:191-202. 1966
  9. ncbi Disturbances in developmental pathways leading to a neurological disorder of genetic origin, "leaner", in mice
    C H Yoon
    Dev Biol 20:158-81. 1969
  10. ncbi Serum esterases in the house mouse, Mus musculus
    M L Petras
    Can J Genet Cytol 9:704-10. 1967

Scientific Experts

  • Chi C Wong
  • Jiesi Xu
  • Ian Cushman
  • Ellen G Duysen
  • Jinhong Sun
  • Kerry W S Ko
  • George Mattheolabakis
  • Nengtai Ouyang
  • Gang Xie
  • Liqun Huang
  • Ka Wing Cheng
  • Basil Rigas
  • Ioannis Papayannis
  • Yuanyuan Li
  • Yang Xu
  • Munaf Zalzala
  • Liya Yin
  • B A Taylor
  • Yanqiao Zhang
  • Gang Cheng
  • Philip M Potter
  • Patrick J Casey
  • Stephanie M Cushman
  • Chunxia Lu
  • Pooja Goel
  • Ram K Menon
  • Travis Maures
  • P Anil Kumar
  • Natinder Saini
  • Oksana Lockridge
  • Jamuna Thimmarayappa
  • Richard Lehner
  • Bruce Erickson
  • S Krishnasamy
  • O von Deimling
  • J Becker-Follmann
  • A G Parker
  • R J Tolwani
  • A Gaa
  • I Hoffman
  • G Scherer
  • A Patel
  • J K Naggert
  • M T Davisson
  • T MacTaggart
  • C Wnek
  • S J Phillips
  • B S Kotlus
  • N Roemer
  • F H Ruddle
  • W G Beamer
  • O H von Deimling
  • N J Gross
  • R Dhand
  • A L Teng
  • R M Schultz
  • E Bausch
  • E Natt
  • S Cresci
  • D M Kurtz
  • F Pinot
  • M E Hinsdale
  • B D Hammock
  • P A Wood
  • M Otsen
  • S C Farmer
  • D P Kelly
  • J Spearow
  • D F Grant
  • S Alonso
  • K R Johnson
  • C A Kozak
  • J M Jones
  • D Simon-Chazottes
  • D F Steiner
  • R Balling
  • J Sumegi
  • P M Nishina
  • S S Kadner
  • E H Leiter
  • Y Rouille
  • O Varlamov
  • M H Meisler
  • T H Roderick
  • M F Seldin
  • R J Carroll
  • G R Uhl
  • J M Rochelle
  • B J Paigen
  • P Gregor

Detail Information

Publications83

  1. pmc Phospho-NSAIDs have enhanced efficacy in mice lacking plasma carboxylesterase: implications for their clinical pharmacology
    Chi C Wong
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, HSC, T 17 Room 080, Stony Brook, NY, 11794 8173, USA
    Pharm Res 32:1663-75. 2015
    The purpose of the study was to evaluate the metabolism, pharmacokinetics and efficacy of phospho-NSAIDs in Ces1c-knockout mice.
  2. pmc Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels
    Jiesi Xu
    Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, United States of America
    PLoS ONE 9:e109663. 2014
    ..In conclusion, the present study uncovers a novel glucose-CES1-glucose pathway which may play an important role in regulating postprandial blood glucose levels. ..
  3. ncbi Esterase-17 (ES-17): characterization and genetic location on chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of the house mouse (Mus musculus)
    J Otto
    Biochem Genet 21:37-48. 1983
    ..1.1.6). ES-17 was shown to be controlled by the structural locus Es-17, located on chromosome 9. From test-cross data, a gene order of Es-17-8.7 +/- 2.5 map units-Mpi-1-10.2 +/- 2.7 map units-Mod-1 was established...
  4. ncbi Polymorphism and linkage of glutathione reductase in Mus musculus
    E A Nichols
    Biochem Genet 13:323-9. 1975
    ..Using an electrophoretic variant for glutathione reductase, we have been able to map the structural gene for this enzyme to chromosome 8 in Mus musculus...
  5. pmc Control of RhoA methylation by carboxylesterase I
    Ian Cushman
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 288:19177-83. 2013
    ..These data provide compelling evidence that C-terminal modification of prenyl proteins, rather than being purely a constitutive process, can serve as a point of regulation of function for this important class of protein. ..
  6. pmc Genetic mapping of ecotropic murine leukemia virus-inducing loci in six inbred strains
    C A Kozak
    J Exp Med 155:524-34. 1982
    ..These studies provide further evidence that endogenous ecotropic V loci are present at different chromosomal sites in unrelated mouse strains and emphasize the role of germ line reinfections in the generation of this diversity...
  7. ncbi Assignment of the gene for adenine phosphoribosyltransferase on the genetic map of mouse chromosome 8
    T B Nesterova
    Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Department, Novosibirsk
    Biochem Genet 25:563-8. 1987
    ..The recombination distance between the centromere and Aprt is 44 +/- 7 cM, and that between Es-1 and Aprt is 25 +/- 2 cM, i.e., the probable order of the markers examined is cen-Es-1-Aprt on chromosome 8...
  8. pmc The genetic control of two types of esterases in inbred strains of the mouse
    F H Ruddle
    Genetics 54:191-202. 1966
  9. ncbi Disturbances in developmental pathways leading to a neurological disorder of genetic origin, "leaner", in mice
    C H Yoon
    Dev Biol 20:158-81. 1969
  10. ncbi Serum esterases in the house mouse, Mus musculus
    M L Petras
    Can J Genet Cytol 9:704-10. 1967
  11. ncbi Biochemical polymorphisms in feral and inbred mice (mus musculus)
    T H Roderick
    Biochem Genet 5:457-66. 1971
  12. pmc Esterase genetics in Mus musculus: expression, linkage, and polymorphism of locus Es-2
    F H Ruddle
    Genetics 62:393-9. 1969
  13. ncbi Linkage of serum esterase and tottering in the mouse
    S Tsuji
    J Hered 60:221-2. 1969
  14. ncbi Allelically-determined isozyme polymorphisms in laboratory populations of mice
    F H Ruddle
    Ann N Y Acad Sci 151:531-9. 1968
  15. ncbi Evidence for allelism of leaner and tottering in the mouse
    S Tsuji
    Genet Res 17:83-8. 1971
  16. ncbi Linkage and expression of the Eg locus controlling inclusion of beta-glucuronidase into microsomes
    T R Karl
    Biochem Genet 11:367-72. 1974
  17. ncbi The genetics of an electrophoretic variant of an erythrocytic protein in the house mouse (Mus musculus)
    G C Kirby
    Anim Blood Groups Biochem Genet 5:153-7. 1974
  18. ncbi Variations among sublines of inbred AKR mice
    R T Acton
    Nat New Biol 245:8-10. 1973
  19. ncbi Glutamate oxalate transaminase (GOT) genetics in Mus musculus: linkage, polymorphism, and phenotypes of the Got-2 and Got-1 loci
    R J DeLorenzo
    Biochem Genet 4:259-73. 1970
  20. ncbi Biochemistry and genetics of esterase-20 (ES-20), a second trimeric carboxylesterase of the house mouse (Mus musculus). II. A unique recombination reveals ES-20 as a hybrid enzyme
    B Wassmer
    Biochem Genet 23:759-70. 1985
    ..This result satisfactorily accounted for the genetic finding, as well as a range of biochemical properties of ES-20...
  21. ncbi Identification and development of a genetically closely-linked carboxylesterase family of the mouse liver
    W Berning
    Comp Biochem Physiol B 80:859-65. 1985
    ..Allelic variation of the temporal genes was more limited than that of the corresponding structural genes...
  22. ncbi Genetic characterization of important mouse strains used in cancer research
    H H Krog
    Hereditas 87:201-4. 1977
  23. ncbi Genetics and evolution of the acute phase proteins in mice
    H Baumann
    Mol Gen Genet 201:505-12. 1985
    ....
  24. ncbi Linkage of the gene for uncoupling protein to esterase-1,2 and haptoglobin in the rat
    M Otsen
    Department of Laboratory Animal Science, University of Utrecht, The Netherlands
    J Hered 84:149-51. 1993
    ..Genetic analysis of a (BN x LEW)LEW backcross showed that Hp is linked to Ucp, thus indicating that the Hp locus is also located on chromosome 19. These results substantiate the linkage homology of RNO 19, MMU 8, and HSA 16...
  25. doi Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons
    Ellen G Duysen
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 5950, USA
    Toxicol Appl Pharmacol 255:214-20. 2011
    ..We hypothesize that acetylcholinesterase activity is induced when cells undergo apoptosis and that consequently there is a rise in the level of plasma acetylcholinesterase...
  26. pmc Esterase 1 is a novel transcriptional repressor of growth hormone receptor gene expression: a unique noncatalytic role for a carboxyesterase protein
    Jinhong Sun
    Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan 48109 5718, USA
    Mol Endocrinol 25:1351-63. 2011
    ..A cDNA phage expression library was screened to identify a phage clone expressing esterase 1 (ES1) binding to the FFA-response element (FARE), L2-D1, in the murine GHR promoter...
  27. doi Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes
    Kerry W S Ko
    Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Biochim Biophys Acta 1791:1133-43. 2009
    ..Overall, these results suggest that Es-x limits hepatic TG accumulation by promoting beta-oxidation...
  28. ncbi LOCI LINKAGE OF SERUM ESTERASE PATTERNS AND OLIGOSYNDACTYLY
    R A Popp
    J Hered 56:107-8. 1965
  29. ncbi Inheritance of serum esterases having different electrophoretic patterns
    R A Popp
    J Hered 53:111-4. 1962
  30. ncbi Molecular cloning, characterization, and differential expression pattern of mouse lung surfactant convertase
    S Krishnasamy
    Research Service, Hines Veterans Affairs Hospital, Hines, Illinois 60141, USA
    Am J Physiol 275:L969-75. 1998
    ..It thus may be the first member of the carboxylesterase family (EC 3.1.1.1) to be expressed in lung parenchyma and the first with a known physiological function...
  31. ncbi Regulation of mouse liver microsomal esterases by clofibrate and sexual hormones
    A G Parker
    Department of Entomology and Environmental Toxicology, University of California, Davis 95616 8584, USA
    Biochem Pharmacol 51:677-85. 1996
    ..Enzyme staining of native polyacrylamide gels reveals that the latter is true, with the majority of esterases present in mouse liver microsomes being induced to a small degree by clofibrate...
  32. ncbi Re-localization of Actsk-1 to mouse chromosome 8, a new region of homology with human chromosome 1
    S Alonso
    Unité de Génétique Moléculaire du Développement, URA 1148, Institut Pasteur, Paris, France
    Mamm Genome 4:15-20. 1993
    ..Intermingling on this scale between human and mouse chromosomal homologies that occurred during evolution creates disorders in comparative linkage studies...
  33. pmc Allelism and linkage studies of murine leukemia virus activation genes in low leukemic strains of mice
    J McCubrey
    J Exp Med 155:1233-8. 1982
    ..Our data are consistent with two possibilities: Inc-1 and Inb-1 are part of the virus-inducing genes Cv-1 and Bv-1, respectively , or Inc-1 and Inb2-1 are tightly linked regulatory genes...
  34. ncbi Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency
    W G Beamer
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Endocrinol 141:33-43. 1994
    ..The role of acd action in adrenal cortical development remains to be established...
  35. ncbi Chromosomal localization of the murine cadherin-11
    I Hoffman
    Institut fur Saugetiergenetik, GSF Forschungszentrum Neuherberg, Oberschleissheim, Germany
    Mamm Genome 6:304. 1995
  36. ncbi Interstrain variation of esterase-22, a new isozyme of the house mouse
    E Eisenhardt
    Comp Biochem Physiol B 73:719-24. 1982
    ..4. A gene locus Es-22 with five alleles is suggested. 5. It is proposed that the genes coding for the carboxylesterase isozyme system on chromosome 8 constitute a multigene family as defined by Hood et al. (1975)...
  37. ncbi Kidney esterases of Mus musculus: further polymorphism of esterase-6, esterase-9, and a new esterase, esterase-20
    H R Nash
    Biochem Genet 20:537-54. 1982
    ..Esterase-20 may be an aggregated product of Es-9. The close linkage of Es-6 and Es-9 is confirmed. Homology of esterase-6 with esterases from other mammalian species is also suggested...
  38. ncbi Purification and characterization of esterase 1F, the albumin esterase of the house mouse (Mus musculus)
    J Otto
    Eur J Biochem 116:285-91. 1981
    ..1.1.1) coded for by chromosome 8. Esterase 1F was compared with three other genetically related isozymes, esterase 2, esterase 7 and esterase 9, with respect to some physical and catalytic properties...
  39. ncbi Esterase-23 (ES-23): characterization of a new carboxylesterase isozyme (EC 3.1.1.1) of the house mouse, genetically linked to ES-2 on chromosome 8
    O H von Deimling
    Biochem Genet 22:769-82. 1984
    ..Of the five phenotypes, only ES-23B was expressed in lung. This variation is apparently controlled by a cis-acting regulatory element, presumably a temporal locus, Es-23t, closely linked to the presumed structural locus Es-23e...
  40. pmc Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice
    N A Jenkins
    J Virol 42:379-88. 1982
    ....
  41. ncbi Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1
    O H von Deimling
    Abteilung für Chemische Pathologie, Universitat Freiburg, Bundesrepublik Deutschland
    Biochem Genet 29:545-57. 1991
    ..From two backcross series, including a total of 274 animals, the gene order (Es-1, Es-9)-3.9 +/- 1.7%-Got-2-3.9 +/- 1.7%-(Es-2, Es-7, Es-23)-0.7 +/- 0.5%- Ctra-1-6.3 +/- 2.2%-Prt-2 was established...
  42. ncbi Esterase-6 (Es-6) in laboratory mice: hormone-influenced expression and linkage relationship to oligosyndactylism (Os), esterase-1 (Es-1), and esterase-2 (Es-2) in chromosome 8
    J E Womack
    Biochem Genet 13:311-22. 1975
    ..A four-point test cross established the gene order Os-Es-1-Es-6-Es-2 within a 10-cM segment on chromosome 8...
  43. ncbi Esterases of Mus musculus: substrate and inhibition characteristics, new isozymes, and homologies with man
    J Peters
    Biochem Genet 16:553-69. 1978
    ..From substrate, inhibition, and molecular weight studies, three homologies between human and mouse esterases are suggested. A new allele at Es-6 is also described...
  44. pmc Chromosomal homology of rabbit (Oryctolagus cuniculus) linkage group VI with rodent species
    R R Fox
    Genetics 93:183-8. 1979
    ..LG VI now contains five loci with the following order and intervening map distances: Es-1, Es-2 complex--6.3 +/- 2.1 cM--Est-1, Est-2 complex--18.5 +/- 3.7 cM--e...
  45. ncbi Identification of a new allele of Es-I segregating in an inbred strain of mice
    E R Soares
    Biochem Genet 17:577-83. 1979
    ..To date, no discernible deleterious effects have been identified as associated with this mutation...
  46. ncbi Polymorphism of esterase 11 in Mus musculus, a further esterase locus on chromosome 8
    J Peters
    Biochem Genet 15:217-26. 1977
    ..In F1 hybrids (IS/Cam X C57BL/Gr), the phenotype shown corresponds to a mixture of the two parental phenotypes. In backcrosses, ES-11 segregates as an autosomal gene, designated Es-11, closely linked to Es-2 and Es-5 on chromosome 8...
  47. ncbi Identification and genetic monitoring of mouse inbred strains using biochemical polymorphisms
    A Groen
    Lab Anim 11:209-14. 1977
    ..These findings emphasize the possibility and the necessity of monitoring the genetic purity of inbred strains of mice. A routine monitoring scheme using body protein-polymorphisms is proposed...
  48. ncbi Genetic study of pancreatic proteinase in mice (Mus musculus): genetic variants of trypsin and chymotrypsin
    T Watanabe
    Biochem Genet 14:697-707. 1976
    ..Prt-3 is present only in the strain Mol-A. Linkage experimentation has shown that Prt-1 is closely linked to Prt-3...
  49. ncbi Genetic study of pancreatic proteinase in mice (Mus musculus): linkage of the Prt-2 locus on chromosome 8
    T Watanabe
    Biochem Genet 14:999-1002. 1976
    ..5% between Es-2 and Prt-2. From these data, the map position of Prt-2 has been estimated on chromosome 8. The Prt-1 and Prt-3 loci, which are linked very closely on the same chromosome, were not determined...
  50. ncbi Genetics of susceptibility to plasmacytoma induction. I. BALB/cAnN (C), C57BL/6N (B6), C57BL/Ka (BK), (C times B6)F1, (C times BK)F1, and C times B recombinant-inbred strains
    M Potter
    J Natl Cancer Inst 54:1413-7. 1975
    ..The distribution pattern of susceptibility and resistance in the C times B Rl strains suggested the presence of a resistance gene on chromosome 9, linkage group II...
  51. ncbi Esterase-1: developmental expression in the mouse and distribution of related proteins in other species
    S S Kadner
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York 10016
    Arch Biochem Biophys 296:435-41. 1992
    b>Esterase 1 (Es-1) is a sexually dimorphic 65-kDa glycoprotein present in plasma and other murine tissues able to hydrolyze a variety of esters including fatty acid esters of estradiol...
  52. ncbi Characterization and functional expression of a cDNA encoding egasyn (esterase-22): the endoplasmic reticulum-targeting protein of beta-glucuronidase
    M Ovnic
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229
    Genomics 11:956-67. 1991
    ..The features of the deduced amino acid sequence of the egasyn cDNA are compared with previously characterized carboxylesterases and with other lumenal ER proteins...
  53. ncbi [Localization of the gene coding for adenine phosphoribosyltransferase on the genetic map of chromosome 8 in the mouse]
    T B Nesterova
    Genetika 24:829-35. 1988
    ..The Aprt gene was mapped using two markers: plasma esterase 1 coded by the gene Es-1 situated at the distance of 26 morgans from the centromere, and a Robertsonian ..
  54. ncbi Characterization of a murine cDNA encoding a member of the carboxylesterase multigene family
    M Ovnic
    Institute for Developmental Research, Children s Hospital Medical Center, Cincinnati, Ohio 45229
    Genomics 9:344-54. 1991
    ..5 kDa. Upon the addition of microsomes, this product was processed into a protein of 60.4 kDa, which is within the size range of monomeric units of mouse carboxylesterases...
  55. ncbi Genetic characterization of esterase 28 (ES-28) of the house mouse
    O H von Deimling
    Pathologisches Institut, Abteilung für Chemische Pathologie, Universitat Freiburg, Bundesrepublik Deutschland
    Biochem Genet 29:55-63. 1991
    ..Four phenotypes are distinguished. Segregation of Es-28 in two backcross series indicated linkage to Es-1, Es-9, and Es-22. The Es-28 locus was placed into esterase cluster 1 on chromosome 8...
  56. ncbi An interspecific backcross linkage map of mouse chromosome 8
    J D Ceci
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 6:72-9. 1990
    ..A conserved linkage group was identified between mouse chromosome 8 and human chromosome 16. The map will be useful for establishing linkage of other markers to mouse chromosome 8...
  57. ncbi Linkage of Nat and Es-1 in the mouse and development of strains congenic for N-acetyltransferase
    S S Mattano
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109 0626
    J Hered 79:430-3. 1988
    ..B and B x A recombinant inbred (RI) strains indicated linkage between the N-acetyltransferase gene (Nat) and the esterase 1 (Es-1) gene, located on mouse chromosome 8...
  58. ncbi A multilocus linkage map of mouse chromosome 8
    C Fletcher
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Genomics 9:737-41. 1991
    ..This analysis positions a new extremely proximal marker on chromosome 8, which is discussed as a potential candidate gene for the nervous locus. These linkage data will be useful for the mapping of additional loci on chromosome 8...
  59. ncbi Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man
    M G Mattei
    INSERM U242, Hopital d Enfants de la Timone, Marseille, France
    Oncogene 5:151-6. 1990
    ..Finally, the present data identify a new segmental homology between mouse and human chromosomes...
  60. pmc Chromosomal assignment of two endogenous ecotropic murine leukemia virus proviruses of the AKR/J mouse strain
    B A Taylor
    J Virol 56:172-5. 1985
    ..Akv-3 is the second ecotropic murine leukemia virus provirus to be mapped near the agouti locus. The results are discussed in relation to possible nonrandomness of viral integration...
  61. pmc Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion
    D D Petersen
    Laboratory of Developmental Pharmacology, National Institute of Child Health and Human Development, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 86:6699-703. 1989
    ..The mechanism of tetrachlorodibenzo-p-dioxin inducibility of the Cyp1a1, Cyp1a2, and Nmo-1 genes is, therefore, independent of the mechanism of Nmo-1 gene activation in untreated c14CoS/c14CoS mice...
  62. pmc Chromosomal mapping of the structural gene coding for the mouse cell adhesion molecule uvomorulin
    H R Eistetter
    Friedrich Miescher Laboratorium, Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    Proc Natl Acad Sci U S A 85:3489-93. 1988
    ..Recombination frequency between Um and the co-segregating loci serum esterase 1 (Es-1) and tyrosine aminotransferase (Tat) places Um about 14 centimorgan (cM) distal to Es-1, and 5 cM proximal ..
  63. ncbi cDNA cloning of esterase 1, the major esterase activity in mouse plasma
    T L Genetta
    Department of Environmental Medicine, New York University Medical Center, New York 10016
    Biochem Biophys Res Commun 151:1364-70. 1988
    We report here the cloning of a partial cDNA for Esterase 1, the major esterase activity in mouse plasma...
  64. ncbi Gene mapping on mouse chromosome 8 by interspecific crosses: new data on a linkage group conserved on human chromosome 16q
    G Scherer
    Institute of Human Genetics, Freiburg, Federal Republic of Germany
    Genomics 5:275-82. 1989
    ..While map distances between HP-TAT,HP-CTRB, and TAT-CTRB of respectively 7, 11, and 9 cM have previously been measured in man, no crossovers between Hp, Tat, and Ctrb were observed in over 100 meioses in the mouse...
  65. ncbi Mapping of the gene for DNA polymerase beta to mouse chromosome 8
    O W McBride
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Cytogenet Cell Genet 53:108-11. 1990
    ..These results provide additional support for the regional localization of polymerase beta on the short arm of human chromosome 8 or the very proximal end of the long arm...
  66. ncbi Chromosomal localization of zinc finger protein genes in man and mouse
    A Ashworth
    Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
    Genomics 4:323-7. 1989
    ..In humans ZFP3 has been localized to chromosome 17p12-17pter and thus is part of the conserved linkage group between this chromosome and the distal half of mouse chromosome 11...
  67. ncbi Esterase-29 (ES-29): biochemical characterization and control by two independent gene loci of a testosterone-dependent mouse serum esterase
    O von Deimling
    Abteilung für Chemische Pathologie, Universityät Freiburg, BRD
    Biochem Genet 30:421-36. 1992
    ..Two alleles were distinguished, Mse-1a (BALB/cJ) and Mse-1m (MOL3/JA, Cas-Bgr), which determine whether ES-29 appears as a single band or a double band, respectively. Mse-1m is dominant to Mse-1a...
  68. ncbi Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression
    A Jacobsson
    J Biol Chem 260:16250-4. 1985
    ..Accordingly, the inability of diabetic and obese mice to thermoregulate is not associated with a lack of UCP mRNA induction...
  69. pmc Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human
    C Blatt
    Weizmann Institute, Rehovoth, Israel
    Proc Natl Acad Sci U S A 85:7642-6. 1988
    ..These mapping assignments will be useful in defining the extent of the G alpha gene family and may help in attempts to correlate specific genetic diseases with genes corresponding to G proteins...
  70. ncbi A mouse linkage testing stock possessing multiple copies of the endogenous ecotropic murine leukemia virus genome
    B A Taylor
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 5:221-32. 1989
    ..Ways of further improving the MEV stock are discussed. The location of the Myb proto-oncogene is defined relative to Sl and one of the C58/J proviruses on chromosome 10...
  71. ncbi Genotyping new BXD recombinant inbred mouse strains and comparison of BXD and consensus maps
    B A Taylor
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 10:335-48. 1999
    ..Alternatively, recombinant genotypes could be selected against during inbreeding owing to allelic interactions affecting fitness. The latter interpretation implies that relatively strong intrachromosomal epistasis is common...
  72. ncbi High-resolution mapping of a linkage group on mouse chromosome 8 conserved on human chromosome 16Q
    J Becker-Follmann
    Institute of Human Genetics, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Mamm Genome 8:172-7. 1997
    ..The following locus order with distances in cM was obtained: (centromere)-Os-4.1-Mmp2-0.2-Ces1,Es1, Es22-1.2-Mt1,D8Mit15-2.2-Got2, D8Mit11-3.7-Es30-0.3-Es2, Es7-0.9-Ctra1,Lcat-0.3-Cdh1, Cadp, Nmor1, D8Mit12-0...
  73. ncbi Structure and chromosomal location of the mouse medium-chain acyl-CoA dehydrogenase-encoding gene and its promoter
    R J Tolwani
    Department of Comparative Medicine, School of Medicine, University of Alabama at Birmingham 35294 0019, USA
    Gene 170:165-71. 1996
    ..Biol. Chem. 268 (1993) 13805-13810]. We have mapped mouse Acadm to the distal end of chromosome 3. Sequences previously localized to chromosome 8 are shown to be a pseudogene, and an additional pseudogene was identified on chromosome 11...
  74. ncbi Morphologic analysis of enteric lesions in conventional and streptomycin-treated inbred C3H/HeN mice infected with Serpulina (Treponema) hyodysenteriae
    J V Mysore
    Department of Veterinary Science, University of Nebraska Lincoln 68583 0905
    Lab Anim Sci 42:7-12. 1992
    ..S. hyodysenteriae was reisolated from 10 of 12 mice in each infected group (A and C) from day 14 (7th day postinoculation) through day 35 (28th day postinoculation).(ABSTRACT TRUNCATED AT 250 WORDS)..
  75. ncbi The AXB and BXA set of recombinant inbred mouse strains
    J D Marshall
    Jackson Laboratory, Bar Harbor, Maine 04609 1500
    Mamm Genome 3:669-80. 1992
    ..Thus, the AXB and BXA set of RI strains will be useful in the genetic analysis of several complex diseases...
  76. ncbi Genetic and developmental regulation of the lipoprotein lipase gene: loci both distal and proximal to the lipoprotein lipase structural gene control enzyme expression
    T G Kirchgessner
    Department of Medicine, University of California, Los Angeles 90024
    J Biol Chem 264:1473-82. 1989
    ..This indicates that combined deficiencies of LPL and hepatic lipase, observed in humans as well as in certain mutant strains of mice, do not result from focal disruptions of a cluster of lipase genes...
  77. ncbi Mapping of the taurine transporter gene to mouse chromosome 6 and to the short arm of human chromosome 3
    A Patel
    Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Genomics 25:314-7. 1995
    ..These data extend a conserved linkage group on mouse chromosome 6 and human chromosome 3p. Deletion of TAUT might contribute to some phenotypic features of the 3p- syndrome...
  78. ncbi Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
    J K Naggert
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nat Genet 10:135-42. 1995
    ..Thus, the fat mutation represents the first demonstration of an obesity-diabetes syndrome elicited by a genetic defect in a prohormone processing pathway...
  79. ncbi Ras-like genes and gene families in the mouse
    G Drivas
    Department of Biochemistry, New York University Medical Center, New York 10016
    Mamm Genome 1:112-7. 1991
    ..Two possible clusters of Ras-like and/or G protein genes were identified, on Chrs 9 and 17...
  80. pmc Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor
    C L MacLeod
    Department of Medicine, University of California, San Diego, La Jolla 92093
    Mol Cell Biol 10:3663-74. 1990
    ..Neither gene product displayed significant homology with other known transmembrane-spanning proteins. Thus, the Tea and Rec-1 genes establish a new family encoding multiple membrane-spanning proteins...
  81. ncbi Isolation, characterization and chromosomal mapping of the mouse tyrosine aminotransferase gene
    G Muller
    J Mol Biol 184:367-73. 1985
    ..Since the albino deletions are located on mouse chromosome 7, the assignment of the TAT gene to chromosome 8 suggests that a regulatory factor(s) affecting TAT gene expression acts in trans...
  82. ncbi Genetic mapping in the mouse of four loci related to the jun family of transcriptional activators
    M Shapiro
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    Somat Cell Mol Genet 17:341-7. 1991
    ..Probes for jun D identified two genetic loci; one, Jund-1, is near Junb on Chr 8, and a second, previously unidentified locus termed Jund-2, was mapped to Chr 2...
  83. ncbi Zinc finger protein gene complexes on mouse chromosomes 8 and 11
    J H Nadeau
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 8:469-76. 1990
    ..Surprisingly, both genes were closely linked to two previously mapped, Krüppel-related zinc finger protein genes, suggesting that they are part of gene complexes...