Cer1

Summary

Gene Symbol: Cer1
Description: cerberus 1, DAN family BMP antagonist
Alias: Cerl, Cerl1, Cerr1, cer-1, cerberus, cer-l, cerberus 1 homolog, cerberus homolog, cerberus-like protein, cerberus-related protein
Species: mouse

Top Publications

  1. ncbi The cerberus-related gene, Cerr1, is not essential for mouse head formation
    W Shawlot
    Genesis 26:253-8. 2000
  2. ncbi Murine cerberus homologue mCer-1: a candidate anterior patterning molecule
    C Biben
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Dev Biol 194:135-51. 1998
  3. ncbi Requirement for Wnt3 in vertebrate axis formation
    P Liu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 22:361-5. 1999
  4. ncbi Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula
    J A Belo
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles 90095 1662, USA
    Mech Dev 68:45-57. 1997
  5. ncbi Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
    W R Waldrip
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell 92:797-808. 1998
  6. pmc Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis
    W Shawlot
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 95:6198-203. 1998
  7. ncbi Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo
    J Ding
    Center for Advanced Biotechnology and Medicine and Dept of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nature 395:702-7. 1998
  8. ncbi Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
    Development 125:5091-104. 1998
  9. ncbi A mouse cerberus/Dan-related gene family
    J J Pearce
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, M5G 1X5, Ontario, Canada
    Dev Biol 209:98-110. 1999
  10. ncbi Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
    I B Barrantes
    Amgen Institute, Ontario Cancer Institute, Departments of Medical Biophysics and Immunology University of Toronto 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 9:470-80. 1999

Research Grants

Scientific Experts

  • Patrick P L Tam
  • Hideharu Hoshino
  • Sally L Dunwoodie
  • STEPHANIE WARE
  • Jeffery R Barrow
  • Joaquim Egea
  • Ingeborg Teppner
  • Karin Schuster-Gossler
  • MARIA J GARCIA GARCIA
  • Y Saga
  • Steffen Biechele
  • Daniel Mesnard
  • Aitana Perea-Gomez
  • Chiharu Kimura-Yoshida
  • Elizabeth J Robertson
  • Jianhua Chu
  • R R Behringer
  • Dario Acampora
  • Michael M Shen
  • Shinichi Aizawa
  • Heiner Westphal
  • Yu Takahashi
  • Mahua Mukhopadhyay
  • Lisa Gonçalves
  • N Ray Dunn
  • S J Kinder
  • Deborah R Farkas
  • Kathryn V Anderson
  • Janet Rossant
  • Yoshihiro Komatsu
  • Leif Oxburgh
  • Daniel B Constam
  • Heiko Lickert
  • Masamichi Yamamoto
  • Isao Matsuo
  • Anne Camus
  • Silvia Engert
  • Wenqing Cai
  • Jehangir N Ahmed
  • W Shawlot
  • Hiroshi Hamada
  • Claire Chazaud
  • J A Belo
  • Zhijie Xiao
  • Melanie Clements
  • William Shawlot
  • E M De Robertis
  • Jose A Belo
  • Erik Willems
  • Stephane D Vincent
  • Pavel Rodriguez
  • A Perea-Gomez
  • Isabelle Migeotte
  • Tambet Tõnissoo
  • T E Tsang
  • M Wakamiya
  • J Rossant
  • Richard R Behringer
  • Jose Antonio Belo
  • Ana Marisa Salgueiro
  • Masayuki Uehara
  • Jiang Fu
  • Yasuhide Ohinata
  • D Acampora
  • Paul L F Tang
  • Yuji Mishina
  • Samara L Lewis
  • Denis Piette
  • Yoshiyasu Fukusumi
  • Tobias Goller
  • Giovanna L Liguori
  • Sebastian J Arnold
  • Mario Filipe
  • Maria Elena Torres-Padilla
  • Kenryo Furushima
  • Qiuxia Guo
  • Konstantinos J Mavrakis
  • J P Martinez-Barbera
  • Sara Marques
  • Cassandre Labelle-Dumais
  • Yu Ping Yang
  • Deborah L Chapman
  • Irina Leaf
  • Pantelis Georgiades
  • Andrew S Rakeman
  • Hiroshi Nakano
  • Akihiko Ishimura
  • Canhe Chen
  • Elizabeth K Bikoff
  • Nadav Ben-Haim

Detail Information

Publications117 found, 100 shown here

  1. ncbi The cerberus-related gene, Cerr1, is not essential for mouse head formation
    W Shawlot
    Genesis 26:253-8. 2000
    The Xenopus cerberus gene encodes a secreted factor expressed in the Spemann organizer that can cause ectopic head formation when its mRNA is injected into Xenopus embryos...
  2. ncbi Murine cerberus homologue mCer-1: a candidate anterior patterning molecule
    C Biben
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Dev Biol 194:135-51. 1998
    Xenopus cerberus (Xcer) is a cytokine expressed in anterior mesendoderm overlapping and surrounding Spemann's gastrula organiser...
  3. ncbi Requirement for Wnt3 in vertebrate axis formation
    P Liu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 22:361-5. 1999
    ..These studies provide genetic proof for the requirement of Wnt3 in primary axis formation in the mouse...
  4. ncbi Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula
    J A Belo
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles 90095 1662, USA
    Mech Dev 68:45-57. 1997
    We report the isolation of mouse cerberus-like (cer-l), a gene encoding a novel secreted protein that is specifically expressed in the anterior visceral endoderm during early gastrulation...
  5. ncbi Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
    W R Waldrip
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell 92:797-808. 1998
    ..Chimera experiments demonstrate these essential activities are contributed by the extraembryonic tissues. Thus, the extraembryonic tissues play critical roles in establishing the body plan during early mouse development...
  6. pmc Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis
    W Shawlot
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 95:6198-203. 1998
    The Xenopus cerberus gene encodes a secreted factor that is expressed in the anterior endomesoderm of gastrula stage embryos and can induce the formation of ectopic heads when its mRNA is injected into Xenopus embryos [Bouwmeester, T...
  7. ncbi Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo
    J Ding
    Center for Advanced Biotechnology and Medicine and Dept of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nature 395:702-7. 1998
    ..Our results indicate that Cripto signalling is essential for the conversion of a proximal-distal asymmetry into an orthogonal anterior-posterior axis...
  8. ncbi Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
    Development 125:5091-104. 1998
    ..Moreover, our data lead us to hypothesize that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification...
  9. ncbi A mouse cerberus/Dan-related gene family
    J J Pearce
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, M5G 1X5, Ontario, Canada
    Dev Biol 209:98-110. 1999
    The Xenopus cerberus gene is able to induce ectopic heads in Xenopus embryos. At the time of its identification, cerberus shared significant homology with only one other protein, the putative rat tumor suppressor protein Dan...
  10. ncbi Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
    I B Barrantes
    Amgen Institute, Ontario Cancer Institute, Departments of Medical Biophysics and Immunology University of Toronto 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 9:470-80. 1999
    ....
  11. ncbi Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping
    D B Constam
    Harvard University, Department of Molecular Biology, Cambridge, MA 02138, USA
    Development 127:245-54. 2000
    ..Overall, we conclude that Furin activity is essential in both extraembryonic and precardiac mesoderm, and in definitive endoderm derivatives...
  12. ncbi Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development
    J A Belo
    Genesis 26:265-70. 2000
    Mouse cerberus-like (cer-l) is a member of the Cerberus/Dan family of secreted factors. As other members of this family of proteins, Cer-l functions in the extracellular space, inhibiting signaling molecules...
  13. ncbi The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation
    J P Martinez Barbera
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    Development 127:2433-45. 2000
    ..All together, these results demonstrate that Hex function is essential in definitive endoderm for normal development of the forebrain, liver and thyroid gland...
  14. ncbi Induction of the mammalian node requires Arkadia function in the extraembryonic lineages
    V Episkopou
    Mammalian Neurogenesis, MRC Clinical Science Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Nature 410:825-30. 2001
    ..Furthermore, our experiments show that Arkadia interacts genetically with the transforming growth factor (TGF)beta-like factor Nodal, implying that Nodal mediates the function of Arkadia in node induction...
  15. pmc The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse
    M Yamamoto
    Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Japan
    Genes Dev 15:1242-56. 2001
    ..These results indicate that a Nodal-FoxH1 signaling pathway plays a central role in A-P patterning and node formation in the mouse...
  16. pmc FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse
    P A Hoodless
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Genes Dev 15:1257-71. 2001
    ..These results show that FoxH1 functions in an activin/nodal-Smad signaling pathway that acts upstream of Foxa2 and is required specifically for patterning the APS and node in the mouse...
  17. ncbi The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 128:3623-34. 2001
    ..The gastrula organizer is therefore composed of a constantly changing population of cells that are allocated to different parts of the axial mesoderm...
  18. ncbi Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm
    Sally L Dunwoodie
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 129:1795-806. 2002
    ....
  19. ncbi Depletion of definitive gut endoderm in Sox17-null mutant mice
    Masami Kanai-Azuma
    Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Development 129:2367-79. 2002
    ..Our findings indicate an important role of Sox17 in endoderm development in the mouse, highlighting the idea that the molecular mechanism for endoderm formation is likely to be conserved among vertebrates...
  20. ncbi Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm
    Heiko Lickert
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Dev Cell 3:171-81. 2002
    ..We provide evidence that ablation of beta-catenin in embryonic endoderm changes cell fate from endoderm to precardiac mesoderm, consistent with the existence of bipotential mesendodermal progenitors in mouse embryos...
  21. ncbi Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks
    Aitana Perea-Gomez
    IGBMC CNRS INSERM, Universite Louis Pasteur, 67404 Illkirch Cedex, CU de, Strasbourg, France
    Dev Cell 3:745-56. 2002
    ..Here, we demonstrate that Cerberus-like(-/-);Lefty1(-/-) compound mutants can develop a primitive streak ectopically in the embryo...
  22. ncbi Extraembryonic proteases regulate Nodal signalling during gastrulation
    Séverine Beck
    Developmental Biology Group, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Cell Biol 4:981-5. 2002
    ..A lack of Spc1 and Spc4 affects both pathways because these proteases also stimulate induction of Bmp4...
  23. ncbi Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo
    Masamichi Yamamoto
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 428:387-92. 2004
    ..the driving force for DVE migration by stimulating the proliferation of visceral endoderm cells, the antagonists Lefty1 and Cerl determine the direction of migration by asymmetrically inhibiting Nodal activity on the future anterior side.
  24. ncbi Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo
    N Ray Dunn
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 131:1717-28. 2004
    ..Collectively, these results demonstrate that dose-dependent Smad2 and Smad3 signals cooperatively mediate cell fate decisions in the early mouse embryo...
  25. pmc The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments
    Markus Bussen
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Genes Dev 18:1209-21. 2004
    ..In summary, Tbx18 appears to act downstream of Mesp2 and Delta/Notch signaling to maintain the separation of anterior and posterior somite compartments...
  26. ncbi The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo
    Canhe Chen
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Development 133:319-29. 2006
    ..Our findings indicate that Gdf3 acts in a Nodal-like signaling pathway in pre-gastrulation development, and provide evidence for the functional conservation of Vg1 activity in mice...
  27. ncbi Zic3 is critical for early embryonic patterning during gastrulation
    Stephanie M Ware
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Dev Dyn 235:776-85. 2006
    ..At later stages, deficiency of Zic3 results in abnormal mesoderm allocation. These results indicate a requirement for Zic3 during early embryogenesis prior to cardiac and visceral organ patterning...
  28. ncbi Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo
    Anne Camus
    Laboratoire de Développement des Vertébrés, Institut Jacques Monod UMR 7592 CNRS, Universités Paris 6 et 7, 2 place Jussieu, 75251 Paris, France
    Dev Biol 295:743-55. 2006
    ....
  29. ncbi Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching
    Andrew S Rakeman
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Development 133:3075-83. 2006
    ..Thus, the Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo...
  30. ncbi Roles of organizer factors and BMP antagonism in mammalian forebrain establishment
    Yu Ping Yang
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710 3709, USA
    Dev Biol 296:458-75. 2006
    ..These results lead to a model in which BMP antagonism supplied by exogenous tissues promotes forebrain establishment and maintenance in the murine ectoderm...
  31. ncbi Disruption of early proximodistal patterning and AVE formation in Apc mutants
    Claire Chazaud
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Development 133:3379-87. 2006
    ..In addition, we found that nuclear beta-catenin and other molecular markers are asymmetrically expressed by 4.5 days...
  32. pmc The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation
    Maria Elena Torres-Padilla
    The Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Dev Biol 309:97-112. 2007
    ..First, we show that the expression of another AVE marker, Cer1, also commences before implantation and its expression becomes consolidated in the subset of ICM cells that ..
  33. doi Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 135:501-11. 2008
    ..Collectively, our experiments establish that Eomes is a key regulator of anteroposterior axis formation, EMT and definitive endoderm specification in the mouse...
  34. pmc Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment
    Wenqing Cai
    Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Genes Dev 27:2332-44. 2013
    ..Here, we show that the endoderm-derived dual Nodal/bone morphogenetic protein (BMP) antagonist Cerberus-1 (Cer1) in embryonic stem cell cultures orchestrates two signaling pathways that direct the SWI/SNF chromatin ..
  35. ncbi The organizer factors Chordin and Noggin are required for mouse forebrain development
    D Bachiller
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles 90095 1662, USA
    Nature 403:658-61. 2000
    ..homologous to the node, partially overlaps with anterior endoderm cells expressing homologues of the AVE markers cerberus, Hex and Hesx1...
  36. ncbi Mesp2 initiates somite segmentation through the Notch signalling pathway
    Y Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    Nat Genet 25:390-6. 2000
    ..Therefore, Mesp2- and Ps1-dependent activation of Notch-signalling pathways might differentially regulate Dll1 expression, resulting in the establishment of the rostro-caudal polarity of somites...
  37. ncbi Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Int J Dev Biol 45:347-55. 2001
    ..associated with the posterior germ layer tissues and the primitive streak (T, Wnt3 and Fgf8) and anterior endoderm (Cer1 and Sox17) revealed that the A-P axis of mutant embryos remains aligned with the proximo-distal plane of the ..
  38. pmc Cell fate decisions within the mouse organizer are governed by graded Nodal signals
    Stephane D Vincent
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 17:1646-62. 2003
    ..These findings conclusively demonstrate that graded Nodal/Smad2 signals govern allocation of the axial mesendoderm precursors that selectively give rise to the ADE and PCP mesoderm...
  39. ncbi Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Development 130:4259-68. 2003
    ..We conclude from our analyses that Mesp2 functions as a central mediator of such Notch pathways and regulates the gene expression required for rostrocaudal patterning of somites...
  40. ncbi Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo
    Gerald C Chu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 131:3501-12. 2004
    ..These results suggest that Smad4 potentiates a subset of TGFbeta-related signals during early embryonic development, but is dispensable for others...
  41. ncbi Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm
    Chiharu Kimura-Yoshida
    Vertebrate Body Plan Group, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minami cho, Chuou ku Kobe, Hyogo 650 0047, Japan
    Dev Cell 9:639-50. 2005
    ..We propose that Wnt/beta-catenin signaling mediates A-P axis polarization by guiding cell migration toward the prospective anterior in the pregastrula mouse embryo...
  42. ncbi The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4
    Nadav Ben-Haim
    Ecole Polytechnique Fédérale de Lausanne EPFL ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Dev Cell 11:313-23. 2006
    ..Based on mathematical modeling, we discuss how these sequential loops control cell fate...
  43. ncbi Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling
    Akihiko Ishimura
    The 21st Century Center of Excellence Program, Akita University School of Medicine, Hondo 1 1 1, Akita, Japan
    Development 133:3919-28. 2006
    ..These results have revealed a novel role for Man1 in angiogenesis and provide the first evidence that vascular remodeling can be regulated at the INM through the interaction between Man1 and Smads...
  44. pmc Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints
    Ingeborg Teppner
    GSF National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Neuherberg, Germany
    BMC Dev Biol 7:68. 2007
    ..We did this by overexpressing a functional copy of the Dll1 gene throughout the paraxial mesoderm, in particular in anterior somite compartments, during somitogenesis in transgenic mice...
  45. pmc Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse
    Isabelle Migeotte
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Biol 8:e1000442. 2010
    ..The data show that Rac1-mediated epithelial migration of the AVE is a crucial step in the establishment of the mammalian body plan and suggest that Rac1 is essential for collective migration in mammalian tissues...
  46. doi Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
    Steffen Biechele
    Department of Molecular Genetics, University of Toronto, ON, Canada
    Dev Biol 355:275-85. 2011
    ..Taken together, these data confirm the importance of Porcn for Wnt secretion and gastrulation and suggest that disruption of early development underlies the male lethality of human PORCN mutants...
  47. pmc Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification
    Melanie Clements
    Molecular Embryology Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK
    Curr Biol 21:1289-95. 2011
    ..Collectively, our results reveal a novel role for p38 in regulating the threshold of Nodal signaling and propose a new mechanism by which A-P axis development can be reinforced during early embryogenesis...
  48. pmc A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation
    Jehangir N Ahmed
    Early Mammalian Development Laboratory, Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia
    Dis Model Mech 6:755-67. 2013
    ..Heterotaxy in patients with PTC-containing ZIC3 transcripts probably arises due to loss of ZIC3 function alone...
  49. doi Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse
    Silvia Engert
    Institute of Stem Cell Research, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Development 140:3128-38. 2013
    ....
  50. pmc In situ hybridization methods for mouse whole mounts and tissue sections with and without additional β-galactosidase staining
    Yoshihiro Komatsu
    School of Biology Oriented Science and Technology, Kinki University, Kinki, Japan
    Methods Mol Biol 1092:1-15. 2014
    ..As a result of the increased sensitivity as well as the color compatibility of S-gal, we successfully combined β-gal staining using S-gal with in situ hybridization using DIG-labeled probes in both whole mounts and sections...
  51. doi AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression
    Hideharu Hoshino
    Laboratory for Vertebrate Body Plan, Center for Developmental Biology CDB, RIKEN Kobe, 2 2 3 Minatojima Minami machi, Chuo Ku, Kobe 650 0046, Japan Electronic address
    Dev Biol 402:175-91. 2015
    ..This study compares the detailed expression patterns of OTX2, HHEX, CER1, LEFTY1 and DKK1 by immunohistology and live imaging at E4.5-E6.5. At E6...
  52. ncbi Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning
    Martyn Donnison
    AgResearch Crown Research Institute, Ruakura Campus, East Street, Hamilton 2001, New Zealand
    Development 132:2299-308. 2005
    ..Embryos without ExE tissue are able to form the anterior visceral endoderm but fail to undergo gastrulation, demonstrating an essential role for the ExE in embryonic patterning during a defined window of development...
  53. ncbi MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube
    Y Saga
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagaya Ku, Tokyo 158, Japan
    Development 126:3437-47. 1999
    ..These results strongly suggest that MesP1 is expressed in the heart tube precursor cells and is required for mesodermal cells to depart from the primitive streak and to generate a single heart tube...
  54. ncbi HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo
    A Perea-Gomez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP163, CU de Strasbourg, France
    Development 126:4499-511. 1999
    ..Moreover, HNF3beta (-)(/)(-);Lim1(-)(/)(-) mutant embryos also exhibit defects in mesoderm patterning that are likely due to lack of specification of anterior primitive streak cells...
  55. ncbi Experimental analysis of the emergence of left-right asymmetry of the body axis in early postimplantation mouse embryos
    T E Tsang
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Cell Mol Biol (Noisy-le-grand) 45:493-503. 1999
    ....
  56. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
    ..5, as visualized by the absence of Hex and Hesx1 and the mislocation of cerberus-like and Lim1 expression. Subsequently, no mesoderm and head structures are generated...
  57. ncbi Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis
    E G Stanley
    Genesis 26:259-64. 2000
    ..one member of a family of cytokines structurally and functionally related to the Xenopus head-inducing factor, Cerberus (xCer)...
  58. ncbi The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo
    A Camus
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 127:1799-813. 2000
    ..The maintenance and function of the rostral AML therefore require inductive signals emanating from the caudal AML. Our results point to a role for AML in the refinement of the anteroposterior patterning and morphogenesis of the brain...
  59. ncbi MesP1 and MesP2 are essential for the development of cardiac mesoderm
    S Kitajima
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Development 127:3215-26. 2000
    ..The persistent and widely distributed expression of Cerberus-like-1(Cer1), Lim1 and Otx2 in the anterior endoderm might be responsible for the maintenance of anterior neural ..
  60. ncbi The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a Delta1 null allele
    J Beckers
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Mech Dev 95:35-46. 2000
    ..However, fine genetic mapping places rv into an interval on chromosome seven that does not contain a gene encoding a known component of the Notch signaling pathway...
  61. pmc Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport
    Shelli M Morris
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    EMBO J 21:1555-64. 2002
    ..This evidence indicates that Dab2 is pleiotropic and regulates both visceral endoderm function and lipoprotein receptor trafficking in vivo...
  62. ncbi Goosecoid and cerberus-like do not interact during mouse embryogenesis
    Ana C Borges
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Int J Dev Biol 46:259-62. 2002
    Mouse Cerberus-like (Cer-l) is a neural inducer molecule, capable of inhibiting Nodal and BMP-4 signals in the extracelular space...
  63. ncbi Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation
    Mahua Mukhopadhyay
    Department of Anatomy, University of Wisconsin Madison Medical School, Madison, WI 53706, USA
    Development 130:495-505. 2003
    ..The expression of several Wnt inhibitors is curtailed in the mutant, suggesting that Wnt pathways may be involved in axial patterning regulated by Ldb1...
  64. ncbi Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity
    Jen Chih Hsieh
    Department of Biochemistry and Cell Biology, Center for Developmental Genetics, State University of New York, Stony Brook, Stony Brook, NY 11794, USA
    Cell 112:355-67. 2003
    ....
  65. ncbi Initiation of gastrulation in the mouse embryo is preceded by an apparent shift in the orientation of the anterior-posterior axis
    Aitana Perea-Gomez
    Laboratoire de Développement des Vertébrés, Institut Jacques Monod, UMR 7592 CNRS, Universite Paris 6 et 7, 2 place Jussieu, 75251 Paris, France
    Curr Biol 14:197-207. 2004
    ..How the establishment of anterior-posterior (AP) polarity relates to the morphology of the postimplantation embryo is, however, unclear...
  66. ncbi Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm
    Daisuke Kurokawa
    Laboratory for Vertebrate Body Plan, Center for Developmental Biology CDB RIKEN Kobe, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0046, Japan
    Development 131:3307-17. 2004
    ..The AN enhancer region is conserved among mouse, human and Xenopus; moreover, the counterpart region in Xenopus exhibited an enhancer activity in mouse anterior neuroectoderm...
  67. pmc The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development
    N Gotoh
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Mol Cell Biol 25:4105-16. 2005
    ..These experiments underscore the critical role of FRS2alpha in mediating multiple processes during embryonic development and reveal a potential new link between FGF and Bmp4 signaling pathways in early embryogenesis...
  68. ncbi Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis
    Jianhua Chu
    Center for Advanced Biotechnology and Medicine and Departments of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Development 132:5539-51. 2005
    ..Taken together, our findings support a model in which Cripto can function in trans as an intercellular mediator of Nodal signaling activity...
  69. ncbi Sfrp5 is not essential for axis formation in the mouse
    Irina Leaf
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA
    Genesis 44:573-8. 2006
    ..These results indicate that Sfrp5 is not essential for axis formation or foregut morphogenesis in the mouse and also imply that Sfrp5 and Dkk1 together are not essential for AVE development...
  70. ncbi Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Dev Biol 304:593-603. 2007
    ..The activation and subsequent suppression of Notch signaling might thus be a crucial event for both stripe pattern formation and boundary formation...
  71. pmc Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation
    Qiuxia Guo
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Development 134:2251-60. 2007
    ....
  72. ncbi Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis
    Jeffery R Barrow
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 312:312-20. 2007
    ....
  73. doi Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo
    Giovanna L Liguori
    IBB Institute for Biotechnology and Bioengineering, Centro de Biomedicina Molecular e Estrutural, Universidade do Algarve, Campus de Gambelas, 8005 135 Faro, Portugal
    Dev Biol 315:280-9. 2008
    ..To investigate the relation between Cripto and Nodal in the early mouse embryo, we removed the Nodal antagonist Cerberus 1 (Cer1) and simultaneously Cripto, by generating Cer1;Cripto double mouse mutants...
  74. pmc Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning
    Masayuki Uehara
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
    Genes Dev 23:1689-98. 2009
    ..These observations suggest that maternal RA must be removed by embryonic CYP26 for correct Nodal expression during embryonic patterning...
  75. doi Kinked tail mutation results in notochord defects in heterozygotes and distal visceral endoderm defects in homozygotes
    Deborah R Farkas
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Dev Dyn 238:3237-47. 2009
    ..Homozygosity for knk results in early embryonic lethality by embryonic day 8.5 due to improper timing of DVE specification and migration, and subsequent failure to establish the AP axis...
  76. pmc Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis
    Jianhua Chu
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    Dev Biol 342:63-73. 2010
    ..Our results indicate that both Cripto and Cryptic function non-cell-autonomously during normal development, and that most if not all Nodal activity in early mouse embryogenesis is EGF-CFC-dependent...
  77. pmc Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst
    Daniel Mesnard
    Swiss Federal Institute of Technology Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, CH 1015 Lausanne, Switzerland
    J Cell Biol 191:129-39. 2010
    ..The unprecedented sensitivity and spatial resolution of CLIP opens exciting new possibilities to elucidate PC functions in vivo...
  78. pmc BMP signaling in the development of the mouse esophagus and forestomach
    Pavel Rodriguez
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 137:4171-6. 2010
    ..Together, these findings suggest multiple roles for BMP signaling in the developing esophagus and forestomach...
  79. doi Nucleotide exchange factor RIC-8 is indispensable in mammalian early development
    Tambet Tõnissoo
    Department of Developmental Biology, University of Tartu, Tartu, Estonia
    Dev Dyn 239:3404-15. 2010
    ..Furthermore, the orientation of the Ric-8(-/-) embryo in the uterus was abnormal. Our study reveals that the activity of RIC-8 protein is irreplaceable for the correct gastrulation of mouse embryo...
  80. doi Identification and functional analysis of novel genes expressed in the Anterior Visceral Endoderm
    Lisa Gonçalves
    Regenerative Medicine Program, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Campus de Gambelas, Faro, Portugal
    Int J Dev Biol 55:281-95. 2011
    ..Symmetrical expression of Lefty1, Cer1 and Dkk1 determines the direction of DVE migration and the future anterior side...
  81. doi Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice
    Zhijie Xiao
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institutet, Stockholm, Sweden
    Dev Dyn 240:2646-56. 2011
    ..5. These findings therefore indicate a novel role for the Crumbs family of proteins...
  82. ncbi The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation
    E H Simpson
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom
    Dev Biol 213:202-6. 1999
    Cer1 is the mouse homologue of the Xenopus Cerberus gene whose product is able to induce development of head structures during embryonic development...
  83. ncbi Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds
    A Zuniga
    Department of Developmental Biology, Faculty of Biology, Utrecht University, The Netherlands
    Nature 401:598-602. 1999
    ....
  84. pmc Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation
    A C Chung
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 21:663-77. 2001
    ..These results suggest that GCNF regulates a novel and critical developmental pathway involved in normal anteroposterior development...
  85. pmc Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality
    Catherine Roberts
    Molecular Medicine Unit, Institute of Child Health, London WC1N 1EH, United Kingdom
    Mol Cell Biol 22:2318-28. 2002
    ..This phenotype could be partially rescued by a CD1 genetic background, although the homozygous mutation was always lethal by embryonic day 11, with death probably resulting from abnormal placentation and failure of cardiac morphogenesis...
  86. pmc Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition
    Jan Willem Voncken
    Division of Molecular Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 100:2468-73. 2003
    ..Importantly, this finding implicates Polycomb-mediated repression of the Cdkn2a locus in early murine development...
  87. ncbi OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm
    Dario Acampora
    MRC Centre for Developmental Neurobiology, New Hunt s House, 4th Floor, King s College London, Guy s Campus, London Bridge, London SE1 1UL, UK
    Gene Expr Patterns 3:497-501. 2003
    ..Patterning and regionalisation of forebrain and midbrain were unaffected as revealed by the expression of diagnostic genes which are highly sensitive to reduction of OTX proteins, such as Fgf8, Pax2 and Gbx2...
  88. pmc Dkk1 and noggin cooperate in mammalian head induction
    Ivan del Barco Barrantes
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Genes Dev 17:2239-44. 2003
    ..The results provide genetic evidence for the dual inhibition model and indicate that dkk1 and noggin functionally cooperate in the head organizer...
  89. pmc P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading
    Paola Di Stefano
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, 10126 Turin, Italy
    Mol Biol Cell 15:787-800. 2004
    ....
  90. ncbi Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development
    Lise Zakin
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Development 131:413-24. 2004
    ..Tsg-/-;Bmp4+/- compound mutants die at birth and display holoprosencephaly, first branchial arch and eye defects. The results show that Tsg functions to promote Bmp4 signaling during mouse head development...
  91. ncbi The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
    Olivia G Kelly
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 131:2803-15. 2004
    ..The effect of reducing, but not eliminating, Wnt signaling in Lrp5(+/-);Lrp6(-/-) mutant embryos provides important insight into the interplay between Wnt, Fgf and Nodal signals in patterning the early mouse embryo...
  92. ncbi Nuclear receptor NR5A2 is required for proper primitive streak morphogenesis
    Cassandre Labelle-Dumais
    Division of Experimental Medicine, Department of Obstetrics and Gynecology, McGill University, RVH, Montreal, Canada
    Dev Dyn 235:3359-69. 2006
    ..Therefore, our results suggest a requirement for NR5A2 in extraembryonic tissues and identify a novel role of this gene in proper primitive streak morphogenesis...
  93. pmc Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover
    Konstantinos J Mavrakis
    Mammalian Neurogenesis, Medical Research Council, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    PLoS Biol 5:e67. 2007
    ..This mechanism can account for achieving efficient and maximum Nodal signaling during embryogenesis and for rapid resetting of target gene promoters allowing cells to respond to dynamic changes in extracellular signals...
  94. pmc Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes
    Chiharu Kimura-Yoshida
    Department of Molecular Embryology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka Prefectural Hospital Organization, Murodo cho, Izumi, Osaka 594 1101, Japan
    Proc Natl Acad Sci U S A 104:5919-24. 2007
    ..Moreover, Foxa2 is essential for expression of the Wnt antagonists, Dkk1 and Cerl, in visceral endoderm during the pre- to early streak stages; however, Foxa2 appears to be dispensable for ..
  95. ncbi Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings
    Kenryo Furushima
    Laboratory for Animal Resources and Genetic Engineering, Center for Developmental Biology CDB, RIKEN Kobe, 2 2 3 Minatojima minami, Chuo Ku, Kobe 650 0047, Japan
    Dev Biol 306:480-92. 2007
    ....
  96. doi Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo
    Yoshiyasu Fukusumi
    Division of Transgenic Animal Science, Advanced Science Research Center, Kanazawa University, Kanazawa, Japan
    Dev Dyn 237:618-29. 2008
    ..Taken together, our findings indicate that Wtap is indispensable for differentiation of mesoderm and endoderm in the mouse embryo...
  97. pmc Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development
    Tobias Goller
    Cell and Molecular Biology, University of Braunschweig, Spielmann Str 7, 38106 Braunschweig, Germany
    Mol Cell Biol 28:6819-27. 2008
    ..In addition, BPTF/FAC1 may also play a role either directly or indirectly in anterior-posterior patterning of the epiblast...
  98. doi Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women
    Paul L F Tang
    Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    J Bone Miner Res 24:1013-21. 2009
    ..this study, we used a genome-wide haplotype association mapping (HAM) approach to identify a haplotype block within Cer1 that partitions inbred mice strains into high and low BMD groups...
  99. doi Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm
    Dario Acampora
    CEINGE Biotecnologie Avanzate, 80145 Naples, Italy
    Mech Dev 126:882-97. 2009
    ....
  100. pmc Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation
    Jiang Fu
    Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:18598-603. 2009
    ..A reciprocal regulation of Wnt and Gpr177 is essential for the patterning of the anterior-posterior axis during mammalian development...
  101. ncbi Axis duplication and anterior identity in the mouse embryo
    P Thomas
    Deutsches Krebsforschungszentrum, Abteilung Angewandte Tumorvirologie, Heidelberg, Germany
    Cold Spring Harb Symp Quant Biol 62:115-25. 1997

Research Grants2

  1. Zic3 and the Control of Body Pattern Formation
    STEPHANIE WARE; Fiscal Year: 2005
    ..Through a combination of supervised research, scientific interchange, and selected coursework within this environment, the candidate will obtain the training necessary to transition to an independent investigator. ..
  2. The role of cell polarity in vertebrate limb outgrowth
    Jeffery Barrow; Fiscal Year: 2007
    ..Furthermore he will examine the epistatic relationship between Fgf and Wnt/PCP signaling in regulating cell polarity. [unreadable] [unreadable] [unreadable]..