Cdx2

Summary

Gene Symbol: Cdx2
Description: caudal type homeobox 2
Alias: Cdx-2, homeobox protein CDX-2, caudal type homeo box 2, caudal-type homeobox protein 2
Species: mouse

Top Publications

  1. doi Cdx mediates neural tube closure through transcriptional regulation of the planar cell polarity gene Ptk7
    Joanne G A Savory
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
    Development 138:1361-70. 2011
  2. pmc Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3
    Angèle Santenard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre national de la recherche scientifique Institut National de la Santé et de la Recherche Médicale U964, Universite de Strasbourg, F 67404 Illkirch, France
    Nat Cell Biol 12:853-62. 2010
  3. ncbi Homeosis and intestinal tumours in Cdx2 mutant mice
    K Chawengsaksophak
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Nature 386:84-7. 1997
  4. pmc Cdx2 determines the fate of postnatal intestinal endoderm
    Emma J Stringer
    Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, UK
    Development 139:465-74. 2012
  5. ncbi Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity
    E H Rings
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Gastroenterology 121:1437-50. 2001
  6. doi Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin
    Robert Odell Stephenson
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Development 137:3383-91. 2010
  7. doi Cdx1 and Cdx2 are functionally equivalent in vertebral patterning
    Joanne G A Savory
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
    Dev Biol 330:114-22. 2009
  8. ncbi Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning
    Martyn Donnison
    AgResearch Crown Research Institute, Ruakura Campus, East Street, Hamilton 2001, New Zealand
    Development 132:2299-308. 2005
  9. doi Increased Cdx protein dose effects upon axial patterning in transgenic lines of mice
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge, UK
    Development 135:2511-20. 2008
  10. ncbi Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice
    Koji Aoki
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Nat Genet 35:323-30. 2003

Research Grants

Scientific Experts

Detail Information

Publications144 found, 100 shown here

  1. doi Cdx mediates neural tube closure through transcriptional regulation of the planar cell polarity gene Ptk7
    Joanne G A Savory
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
    Development 138:1361-70. 2011
    The vertebrate Cdx genes (Cdx1, Cdx2 and Cdx4) encode homeodomain transcription factors with well-established roles in anteroposterior patterning...
  2. pmc Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3
    Angèle Santenard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre national de la recherche scientifique Institut National de la Santé et de la Recherche Médicale U964, Universite de Strasbourg, F 67404 Illkirch, France
    Nat Cell Biol 12:853-62. 2010
    ..Our work demonstrates a role for a modifiable residue within a histone-variant-specific context during reprogramming and identifies a novel function for mammalian H3.3 in the initial formation of dsRNA-dependent heterochromatin...
  3. ncbi Homeosis and intestinal tumours in Cdx2 mutant mice
    K Chawengsaksophak
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Nature 386:84-7. 1997
    ..There are three mouse homologues of Drosophila caudal: Cdx1 (ref. 2), Cdx2 (ref. 3) and Cdx4 (ref. 4). We have generated a null mutation of murine Cdx2 by homologous recombination...
  4. pmc Cdx2 determines the fate of postnatal intestinal endoderm
    Emma J Stringer
    Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, UK
    Development 139:465-74. 2012
    Knock out of intestinal Cdx2 produces different effects depending upon the developmental stage at which this occurs. Early in development it produces histologically ordered stomach mucosa in the midgut...
  5. ncbi Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity
    E H Rings
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Gastroenterology 121:1437-50. 2001
    b>Cdx2 is critical in intestinal proliferation and differentiation. Modulation of Cdx2 function in response to cellular signaling is to be elucidated...
  6. doi Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin
    Robert Odell Stephenson
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Development 137:3383-91. 2010
    ..A larger proportion of cells than normal showed expression of TE markers such as Cdx2, suggesting that formation of an organized epithelium is not necessary for TE-specific gene expression...
  7. doi Cdx1 and Cdx2 are functionally equivalent in vertebral patterning
    Joanne G A Savory
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
    Dev Biol 330:114-22. 2009
    ..However, the lack of a Cdx2 null mutant makes these analyses incomplete...
  8. ncbi Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning
    Martyn Donnison
    AgResearch Crown Research Institute, Ruakura Campus, East Street, Hamilton 2001, New Zealand
    Development 132:2299-308. 2005
    ..Embryos without ExE tissue are able to form the anterior visceral endoderm but fail to undergo gastrulation, demonstrating an essential role for the ExE in embryonic patterning during a defined window of development...
  9. doi Increased Cdx protein dose effects upon axial patterning in transgenic lines of mice
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge, UK
    Development 135:2511-20. 2008
    ..axial patterning in embryos, we made lines of mice OE1, OE2 and OE4 that overexpress each of the Cdx genes Cdx1, Cdx2 and Cdx4, respectively...
  10. ncbi Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice
    Koji Aoki
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Nat Genet 35:323-30. 2003
    The mammalian homeobox transcription factor CDX2 has key roles in intestinal development and differentiation...
  11. ncbi Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway
    Claire Chazaud
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G1X5, Canada
    Dev Cell 10:615-24. 2006
    ..We propose a model in which the ICM develops as a mosaic of EPI and PE progenitors at E3.5, dependent on Grb2-Ras-MAP kinase signaling, followed by later segregation of the progenitors into the appropriate cell layers...
  12. ncbi The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation
    Toshihiko Ezaki
    Division of Gastroenterology 650 CRB, Department of Medicine, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Physiol Gastrointest Liver Physiol 293:G54-65. 2007
    The homeodomain transcription factors Cdx1 and Cdx2 are regulators of intestine-specific gene expression. They also regulate intestinal cell differentiation and proliferation; however, these effects are poorly understood...
  13. ncbi Homeobox gene expression in the intestinal epithelium of adult mice
    R James
    Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, P O Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Biol Chem 266:3246-51. 1991
    ..These observations suggest that homeobox gene expression may play an important role in cellular differentiation in the adult intestine...
  14. ncbi Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium
    R James
    Department of Medicine, University of Melbourne, Parkville, Victoria Australia
    J Biol Chem 269:15229-37. 1994
    ..We conclude that cdx-2 is expressed specifically in gut epithelium where it is not restricted to a particular cell lineage. Rather, the rostrocaudal expression gradient suggests that it may play a role in specifying positional identity...
  15. pmc A homeodomain protein related to caudal regulates intestine-specific gene transcription
    E Suh
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104
    Mol Cell Biol 14:7340-51. 1994
    ....
  16. pmc An intestine-specific homeobox gene regulates proliferation and differentiation
    E Suh
    Department of Medicine, University of Pennsylvania, Philadelphia 19104 6144, USA
    Mol Cell Biol 16:619-25. 1996
    ..Here we show that an intestine-specific homeobox gene, Cdx2, is a transcription factor that regulates both proliferation and differentiation in intestinal epithelial cells...
  17. ncbi Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis
    G V Mallo
    U 315 INSERM, Marseille, France
    Int J Cancer 74:35-44. 1997
    ..The highest degree of similarity was with the murine Cdx1 for 6G2, and with the murine Cdx2 and hamster Cdx3 for 32D6...
  18. pmc Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation
    O Lorentz
    Institut National de la Sante et de la Recherche Medicale, Unité 381, 67200 Strasbourg, France
    J Cell Biol 139:1553-65. 1997
    ..the human colon adenocarcinoma cell line Caco2-TC7 has been stably transfected with plasmids synthesizing Cdx1 and Cdx2 sense and antisense RNAs...
  19. pmc Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice
    F Beck
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne 3052, Australia
    Proc Natl Acad Sci U S A 96:7318-23. 1999
    The homeobox gene Cdx2, a homologue of the Drosophila gene caudal, has been implicated in the control of cell differentiation in the intestinal epithelium...
  20. ncbi Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice
    Y Tamai
    Banyu Tsukuba Research Institute Merck, Ibaraki, Japan
    Cancer Res 59:2965-70. 1999
    To determine the biological role of caudal-like homeobox gene CDX2, we constructed knockout mice in which its mouse homologue Cdx2 was inactivated by homologous recombination, placing a bacterial lacZ gene under the control of the Cdx2 ..
  21. ncbi Cdx1 and cdx2 expression during intestinal development
    D G Silberg
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 119:961-71. 2000
    The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, and maintenance of the intestinal phenotype...
  22. ncbi Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression
    M Ikeya
    Center for Molecular and Developmental Biology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo ku, 606 8502, Kyoto, Japan
    Mech Dev 103:27-33. 2001
    ..These results indicate that Wnt-3a is necessary for correct anteroposterior patterning of vertebra, and that cdx-1 may be one of the mediator genes of Wnt-3a signaling in this process...
  23. ncbi Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation
    Eric van den Akker
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Development 129:2181-93. 2002
    ..Two of the three mouse Cdx paralogues, Cdx 1 and Cdx2, are expressed early in a Hox-like manner in the three germ layers...
  24. ncbi Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice
    Hiroyuki Mutoh
    Department of Gastroenterology, Jichi Medical School, Yakushiji 3311 1, Minamikawachimachi, Kawachigun, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 294:470-9. 2002
    ..To clarify how an intestine-specific homeobox gene, Cdx2, affects the morphogenesis of gastric mucosa, we generated transgenic mice expressing Cdx2 in parietal cells...
  25. ncbi A study of regional gut endoderm potency by analysis of Cdx2 null mutant chimaeric mice
    Felix Beck
    Department of Biochemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK
    Dev Biol 255:399-406. 2003
    Inactivation of Cdx2 by homologous recombination results in the development of forestomach epithelium at ectopic sites in pericaecal areas of the midgut of heterozygote mice...
  26. pmc The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development
    C Bonhomme
    INSERM, Unit 381, 3 Ave Molière, 67200 Strasbourg, France
    Gut 52:1465-71. 2003
    During development, the homeobox gene Cdx2 exerts a homeotic function, providing the positional information necessary for correct specification of the midgut endoderm...
  27. ncbi Cdx1 or Cdx2 expression activates E-cadherin-mediated cell-cell adhesion and compaction in human COLO 205 cells
    Matthew S Keller
    Division of Gastroenterology 660 CRB, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Physiol Gastrointest Liver Physiol 287:G104-14. 2004
    ..The Cdx homeodomain transcription factors (Cdx1 and Cdx2) regulate intestine-specific gene expression and intestinal epithelial differentiation...
  28. pmc Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos
    Alex Gregorieff
    Netherlands Institute for Developmental Biology and Center for Biomedical Genetics, Hubrecht Laboratory, Uppsalalaan, CT Utrecht, The Netherlands
    EMBO J 23:1825-33. 2004
    ..Our results reveal a novel role for Wnt signalling in early gut morphogenesis and suggest that specific Wnt-driven patterning events are determined by the unique tissue distribution of Tcf/Lef family members...
  29. pmc Cdx2 is essential for axial elongation in mouse development
    Kallayanee Chawengsaksophak
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Proc Natl Acad Sci U S A 101:7641-5. 2004
    Inactivation of Cdx2 leads to preimplantation embryonic lethality...
  30. ncbi Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
    Dan Strumpf
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Ontario, Canada
    Development 132:2093-102. 2005
    ..The T-box protein eomesodermin (Eomes) and the caudal-type homeodomain protein Cdx2 are expressed in the TE, and both Eomes and Cdx2 homozygous mutant embryos die around the time of implantation...
  31. pmc Derivation of germ-line-competent embryonic stem cell lines from preblastocyst mouse embryos
    Paul J Tesar
    Mammalian Development Laboratory, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Proc Natl Acad Sci U S A 102:8239-44. 2005
    ..This finding raises the interesting question of whether ES cell lines derived from embryos at different stages of preimplantation development possess the same potential...
  32. ncbi Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation
    Hitoshi Niwa
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minamimachi, Kobe, Hyogo 650 0047, Japan
    Cell 123:917-29. 2005
    ..We show here that this event can be mimicked by overexpression of Caudal-related homeobox 2 (Cdx2), which is sufficient to generate proper trophoblast stem (TS) cells...
  33. ncbi Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm
    Natalia G Kan
    Max Planck Institut fur Immunbiologie, Abteilung für Molekulare Embryologie, Stubeweg 51, D 79108 Freiburg, Germany
    Development 134:31-41. 2007
    ..Thus, N-cadherin can maintain epithelia in differentiating ES cells, but not during the formation of the trophectoderm. Our results point to a specific and unique function for E-cadherin during mouse preimplantation development...
  34. pmc Crucial role of Bysl in mammalian preimplantation development as an integral factor for 40S ribosome biogenesis
    Kenjiro Adachi
    Institute of Medical Science, University of Tokyo, Minato ku, Toyko 108 8639, Japan
    Mol Cell Biol 27:2202-14. 2007
    ..These findings provide evidence for a crucial role of Bysl as an integral factor for ribosome biogenesis and suggest a critical dependence of blastocyst formation on active translation machinery...
  35. ncbi Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development
    Rieko Yagi
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, 6 Center Drive, Bethesda, MD 20892 2753, USA
    Development 134:3827-36. 2007
    ..Tead4(-/-) embryos do not express trophectoderm-specific genes, such as Cdx2, but do express ICM-specific genes, such as Oct4 (also known as Pou5f1)...
  36. ncbi Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation
    Takao Hinoi
    Department of Internal Medicine, The Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 2200, USA
    Cancer Res 67:9721-30. 2007
    ..We defined human CDX2 sequences conferring colon epithelium-preferential transgene expression in the adult mouse...
  37. ncbi Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo
    Amy Ralston
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, MARS Building, Toronto Medical Discovery Tower, 101 College St, Toronto, ON, Canada
    Dev Biol 313:614-29. 2008
    ..The Caudal-like transcription factor Cdx2 is required for repression of inner cell mass genes Oct4 and Nanog in the trophectoderm...
  38. ncbi Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos
    Noriyuki Nishioka
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo, Kobe, Hyogo 650 0047, Japan
    Mech Dev 125:270-83. 2008
    ..Differentiation of TE is regulated by the transcription factor Caudal-related homeobox 2 (Cdx2), but the mechanisms which act upstream of Cdx2 expression remain unknown...
  39. doi Blastomeres of the mouse embryo lose totipotency after the fifth cleavage division: expression of Cdx2 and Oct4 and developmental potential of inner and outer blastomeres of 16- and 32-cell embryos
    Aneta Suwinska
    Department of Embryology, Institute of Zoology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02 096 Poland
    Dev Biol 322:133-44. 2008
    ..In 24 h old blastocysts developed from blastomeres derived from 16-cell embryos the expression of Cdx2 protein was upregulated in outer cells (new trophectoderm) of the inner cells-derived aggregates and downregulated ..
  40. pmc Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst
    Berenika Plusa
    Developmental Biology Program, Sloan Kettering Institute, New York, USA
    Development 135:3081-91. 2008
    ..Subsequently, a gradual progression towards a mutually exclusive expression of PrE- and EPI-specific markers occurs. Finally, cell sorting is achieved by a variety of cell behaviours and by selective apoptosis...
  41. pmc Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo
    Agnieszka Jedrusik
    Wellcome Trust Cancer Research UK Gurdon Institute, Cambridge CB2 1QN, United Kingdom
    Genes Dev 22:2692-706. 2008
    ..Outside cells become committed to the trophectoderm at the blastocyst stage through Cdx2 activity, but here we show that Cdx2 can also act earlier to influence cell allocation...
  42. pmc Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5
    Ray Kit Ng
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
    Nat Cell Biol 10:1280-90. 2008
    ..Elf5 creates a positive-feedback loop with the TS cell determinants Cdx2 and Eomes that is restricted to the trophoblast lineage by epigenetic regulation of Elf5...
  43. doi The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass
    Noriyuki Nishioka
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Dev Cell 16:398-410. 2009
    ..Here, we show that transcriptionally active Tead4 can induce Cdx2 and other trophoblast genes in parallel in embryonic stem cells...
  44. pmc Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
    Nan Gao
    Department of Genetics, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 16:588-99. 2009
    We demonstrate that conditional ablation of the homeobox transcription factor Cdx2 from early endoderm results in the replacement of the posterior intestinal epithelium with keratinocytes, a dramatic cell fate conversion caused by ectopic ..
  45. pmc GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates Cdx2 gene expression
    Pratik Home
    Institute of Maternal Fetal Biology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 284:28729-37. 2009
    ..we found that, knockdown of GATA3 by RNA interference (RNAi) down-regulates expression of caudal-type homeobox 2 (CDX2), a key regulator of the TE lineage...
  46. pmc Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
    Akira Nishiyama
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cell Stem Cell 5:420-33. 2009
    ..Of the 50 TFs, Cdx2 provoked the most extensive transcriptome perturbation in ESCs, followed by Esx1, Sox9, Tcf3, Klf4, and Gata3...
  47. doi CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium
    Fumihiko Kakizaki
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto, Japan
    Gastroenterology 138:627-35. 2010
    Caudal-related homeodomain transcription factors CDX1 and CDX2 regulate gut development and differentiation of intestinal epithelial cells; they are candidate tumor suppressors of colorectal carcinomas...
  48. doi Cdx2 regulation of posterior development through non-Hox targets
    Joanne G A Savory
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    Development 136:4099-110. 2009
    The homeodomain transcription factors Cdx1, Cdx2 and Cdx4 play essential roles in anteroposterior vertebral patterning through regulation of Hox gene expression. Cdx2 is also expressed in the trophectoderm commencing at E3...
  49. pmc Maternally and zygotically provided Cdx2 have novel and critical roles for early development of the mouse embryo
    Agnieszka Jedrusik
    The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Dev Biol 344:66-78. 2010
    ..Elimination of zygotic expression of trophectoderm-specific transcription factor Cdx2 leads to defects in the maintenance of the blastocyst cavity, suggesting that it participates only in the late ..
  50. doi Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism
    Daniel M Messerschmidt
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Dev Biol 344:129-37. 2010
    Early lineage segregation in mouse development results in two, either CDX2- or OCT4/NANOG-positive, cell populations. CDX2-positive cells form the trophectoderm (TE), OCT4/NANOG-positive cells the inner cell mass (ICM)...
  51. pmc Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2
    Michael P Verzi
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 19:713-26. 2010
    ..intestinal epithelial cells and found enrichment of transcription factor-binding motifs corresponding to CDX2, a critical regulator of the intestine...
  52. pmc Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development
    Mary Ann S Crissey
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 140:517-528.e8. 2011
    Caudal-related homeobox protein 2 (Cdx2) is an intestine-specific transcription factor that is important for intestinal development and intestine-specific gene expression...
  53. pmc Initiation of trophectoderm lineage specification in mouse embryos is independent of Cdx2
    Guangming Wu
    Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Munster, Germany
    Development 137:4159-69. 2010
    ..b>Cdx2, the first transcription factor expressed specifically in the developing TE, is crucial for the differentiation of ..
  54. pmc Essential and redundant functions of caudal family proteins in activating adult intestinal genes
    Michael P Verzi
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Biol 31:2026-39. 2011
    ..We conditionally inactivated mouse Cdx2, a dominant regulator of intestinal development, and mapped its genome occupancy in adult intestinal villi...
  55. pmc Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett's esophagus
    Jianping Kong
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e18280. 2011
    ..Transgenic mice were derived in which the transcription factor Cdx2 is expressed in squamous epithelium using the murine Keratin-14 gene promoter...
  56. pmc BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages
    Andreia S Bernardo
    The Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge CB2 0SZ, UK
    Cell Stem Cell 9:144-55. 2011
    ..These conditions induced cells with high levels of BRACHYURY (BRA) that coexpressed CDX2. BRA was necessary for and preceded CDX2 expression; both genes were essential for expression not only of ..
  57. doi Cdx regulates Dll1 in multiple lineages
    Stephanie Grainger
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
    Dev Biol 361:1-11. 2012
    ..The murine Cdx homologues Cdx1, Cdx2 and Cdx4 play important roles in anterior-posterior patterning of the embryonic axis and the intestine, as well as ..
  58. doi Cdx function is required for maintenance of intestinal identity in the adult
    Alexa Hryniuk
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada, K17 8M5
    Dev Biol 363:426-37. 2012
    The homeodomain transcription factors Cdx1 and Cdx2 are expressed in the intestinal epithelium from early development, with expression persisting throughout the life of the animal...
  59. pmc Generation and live imaging of an endogenous Cdx2 reporter mouse line
    Katie McDole
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genesis 50:775-82. 2012
    ..We have generated a reporter line in which eGFP is fused to the endogenous locus of Cdx2, a transcription factor essential for trophectoderm specification, allowing us to visualize cell fate decisions in ..
  60. pmc Maternal Cdx2 is dispensable for mouse development
    Stephanie Blij
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    Development 139:3969-72. 2012
    ..The caudal domain transcription factor CDX2 has been reported to act as a maternal determinant regulating cell fate decisions in mouse development...
  61. pmc Asymmetric localization of Cdx2 mRNA during the first cell-fate decision in early mouse development
    Maria Skamagki
    The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
    Cell Rep 3:442-57. 2013
    ..The transcription factor Cdx2 plays a key role in the first cell-fate decision...
  62. pmc Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst
    Tristan Frum
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Dev Cell 25:610-22. 2013
    ..Finally, we show that Oct4 is required for the expression of multiple EPI and PE genes as well as multiple metabolic pathways essential for the continued growth of the preimplantation embryo. ..
  63. doi The Hippo pathway member Nf2 is required for inner cell mass specification
    Katie Cockburn
    Department of Molecular Genetics, University of Toronto, ON M5S 1A8, Canada
    Curr Biol 23:1195-201. 2013
    ..of the embryo, Yap is nuclear localized and cooperates with Tead4 to induce the TE-specifying transcription factor Cdx2. In inside cells, Lats1/2 phosphorylate Yap and prevent its nuclear localization...
  64. pmc Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation
    Chanchao Lorthongpanich
    Mammalian Development Laboratory, Institute of Medical Biology, Singapore
    Genes Dev 27:1441-6. 2013
    ..We therefore conclude that precisely timed YAP localization in early morulae is essential to prevent trophectoderm marker expression in, and lineage specification of, the ICM. ..
  65. pmc Establishment of totipotency does not depend on Oct4A
    Guangming Wu
    Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Röntgenstrasse 20, 48149 Munster, Germany
    Nat Cell Biol 15:1089-97. 2013
    ....
  66. doi FGF4 is a limiting factor controlling the proportions of primitive endoderm and epiblast in the ICM of the mouse blastocyst
    Dayana Krawchuk
    Goodman Cancer Research Centre, Department of Human Genetics, McGill University, 1160 Pine Avenue West, Rm 419, Canada
    Dev Biol 384:65-71. 2013
    ..We conclude that the amount of FGF4 is limited and regulates PE/EPI proportions in the mouse embryo...
  67. pmc GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst
    Nadine Schrode
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Dev Cell 29:454-67. 2014
    ..This study provides a framework for quantitative analyses of mammalian embryos and establishes GATA6 as a nodal point in the gene regulatory network driving ICM lineage specification. ..
  68. ncbi Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice
    Debra G Silberg
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 122:689-96. 2002
    ..b>Cdx2, a transcription factor whose expression is normally limited to the intestine, has been detected in gastric ..
  69. doi Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2
    Amy Ralston
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, MARS Building, Toronto Medical Discovery Tower, Toronto, ON M5G 1L7, Canada
    Development 137:395-403. 2010
    ..The transcription factor Cdx2 plays a central role by repressing pluripotency genes, such as Oct4, and promoting extraembryonic trophoblast fate ..
  70. ncbi Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes
    F Beck
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Dev Dyn 204:219-27. 1995
    ....
  71. ncbi cdx4/lacZ and cdx2/lacZ protein gradients formed by decay during gastrulation in the mouse
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Cambridge, UK
    Int J Dev Biol 49:901-8. 2005
    Expression of the mouse caudal genes cdx4 and cdx2 is examined by use of lacZ reporter constructs expressed in transgenic mouse embryos. During early gastrulation, up to at least 8...
  72. ncbi The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice
    Johan van Nes
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
    Development 133:419-28. 2006
    ..A subtle contribution of Cdx4 to anteroposterior (AP) vertebral patterning was revealed in Cdx1/Cdx4 and Cdx2/Cdx4 compound mutants...
  73. ncbi Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells
    Katja Schenke-Layland
    Cardiovascular Research Laboratory, UCLA School of Medicine, 675 C E Young Dr, MRL 3 645, Los Angeles, California 90095 1760, USA
    Stem Cells 25:1529-38. 2007
    ..was only seen in ES cell lines maintained on embryonic feeder layers and was caudal-type homeobox protein 2 (Cdx2)-dependent, consistent with Cdx2's postulated role in trophoectoderm commitment...
  74. doi Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene
    Fairouz Benahmed
    INSERM, U682, Strasbourg, France
    Gastroenterology 135:1238-1247, 1247.e1-3. 2008
    The Cdx2 homeobox gene exerts multiple functions including trophectoderm specification, antero-posterior patterning, and determination of intestinal identity...
  75. pmc RBM19 is essential for preimplantation development in the mouse
    Jian Zhang
    Division of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin and Children s Research Institute, Milwaukee, WI 53226, USA
    BMC Dev Biol 8:115. 2008
    ..Here we analyzed the role of RBM19 during mouse embryonic development by generating mice containing a mutation in the Rbm19 locus via gene-trap insertion...
  76. ncbi The caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells
    B Laser
    Clinical Diabetology, Department of Medicine, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    J Biol Chem 271:28984-94. 1996
    ..We therefore conclude that the caudal-related gene cdx-2/3 is implicated in the transcriptional control of glucagon gene expression in the alpha cells of the islets of Langerhans...
  77. pmc Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis
    Hirotaka Tao
    Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology CDB, Chuo Ku, Kobe, Japan
    Dev Biol 364:138-48. 2012
    ..The cell polarity phenotype was efficiently rescued by nuclear but not cytoplasmic Pk2, demonstrating the nuclear localization of Pk2 is critical for its function...
  78. pmc Stress induces AMPK-dependent loss of potency factors Id2 and Cdx2 in early embryos and stem cells [corrected]
    Yufen Xie
    Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Stem Cells Dev 22:1564-75. 2013
    ..We assayed the expression of putative potency-maintaining phosphorylated Cdx2 ser60 in the oocyte, two-cell stage embryo, blastocyst, and in TSC...
  79. doi The H19 induction triggers trophoblast lineage commitment in mouse ES cells
    Hiroaki Fujimori
    Division of Genome Stability Research, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 436:313-8. 2013
    ..blastcyst is regulated by a reciprocal repression of the key transcriptional factors; Oct3/4 dominancy inhibits Cdx2 expression in inner cell mass (ICM) and leads them to epiblast/primitive ectoderm but Cdx2 dominancy in ..
  80. ncbi The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation
    K H Kaestner
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104 6145, USA
    Genes Dev 11:1583-95. 1997
    ....
  81. ncbi Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epithelium
    E Suh
    Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Gastrointest Liver Physiol 280:G149-56. 2001
    ..Using cDNA differential display, we identified clusterin as a prominently induced gene in a Cdx2-regulated cellular model of intestinal differentiation...
  82. ncbi Anterior expression of the caudal homologue cCdx-B activates a posterior genetic program in avian embryos
    L A Ehrman
    Division of Molecular Cardiovascular Biology, The Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Dev Dyn 221:412-21. 2001
    ..These results support an important role for cCdx-B in initiating a posterior program of gene expression that includes Wnt signaling molecules and the Hox cluster genes...
  83. ncbi Novel interaction at the Cdx-2 binding sites of the lactase-phlorizin hydrolase promoter
    Herbert M van Wering
    Division of Gastroenterology and Nutrition, Department of Medicine, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Biochem Biophys Res Commun 299:587-93. 2002
    ..These data are consistent with the hypothesis that NF-LPH1/R represses LPH gene expression in non-Cdx-2-producing cells, and that this repression is released in cells that synthesize Cdx-2, such as those in the intestinal epithelium...
  84. ncbi Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm
    Melany Jackson
    John Hughes Bennett Laboratory, University of Edinburgh, Scotland, United Kingdom
    Dev Dyn 228:740-4. 2003
    ....
  85. pmc Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia
    Vijay P S Rawat
    GSF Clinical Cooperative Group Leukemia and Department of Medicine III, Grosshadern, Ludwig Maximilians University, 81377 Munich, Germany
    Proc Natl Acad Sci U S A 101:817-22. 2004
    ..In t(12;13)(p13;q12) AML, ectopic expression of the homeobox gene CDX2 was detected in addition to expression of the ETV6-CDX2 fusion gene, generated by the chromosomal translocation...
  86. pmc Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
    H Takeda
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Br J Cancer 90:701-4. 2004
    ..prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/-), Smad4(+/-) and Cdx2(+/-)mice...
  87. pmc Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment
    Marcela Guzman-Ayala
    Developmental Biology Group, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 101:15656-60. 2004
    ..Because the ExE itself produces the proteases Furin and PACE4 to activate Nodal, it represents the first example, to our knowledge, of a stem cell compartment that actively maintains its own microenvironment...
  88. ncbi Cdx binding determines the timing of enhancer activation in postnatal duodenum
    Elizabeth A Maier
    Department of Pediatrics, Division of Developmental Biology, University of Cincinnati College of Medicine and Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Biol Chem 280:13195-202. 2005
    ..Two sites were identified that bound both Cdx1 and Cdx2. Mutations were identified in these two sites that completely and specifically eliminated Cdx binding...
  89. ncbi Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine
    Hiroyuki Mutoh
    Department of Gastroenterology, Jichi Medical School, Tochigi, Japan
    Int J Dev Biol 49:867-71. 2005
    ..We report in this study that the transcription factor Cdx2 functions to define absorptive enterocytes during intestinal epithelial differentiation...
  90. ncbi The caudal-related protein cdx2 promotes trophoblast differentiation of mouse embryonic stem cells
    Elena Tolkunova
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Stubeweg 51, 79108 Freiburg, Germany
    Stem Cells 24:139-44. 2006
    ..The caudal-related homeobox protein Cdx2 is a transcriptional regulator essential for trophoblast lineage, functioning as early as implantation...
  91. pmc Barx1 and evolutionary changes in feeding
    Isabelle Miletich
    Department of Craniofacial Development, Dental Institute, Kings College London, UK
    J Anat 207:619-22. 2005
    ....
  92. ncbi Functional characterization of the CCL25 promoter in small intestinal epithelial cells suggests a regulatory role for caudal-related homeobox (Cdx) transcription factors
    Anna Ericsson
    Immunology Section, Stem Cell Center, Biomedical Centre I 13, Lund University, S 22184 Lund, Sweden
    J Immunol 176:3642-51. 2006
    ..Together these results demonstrate a unique pattern of regulation for CCL25 and suggest a role for Cdx proteins in regulating CCL25 transcription...
  93. pmc Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development
    Michael A Gonzalez
    Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, UK
    Genes Dev 20:1880-4. 2006
    ..Geminin is also down-regulated in TGCs of wild-type blastocysts during S and gap-like phases by proteasome-mediated degradation, suggesting that loss of geminin is part of the mechanism regulating endoreduplication...
  94. pmc Murine inner cell mass-derived lineages depend on Sall4 function
    Ulrich Elling
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Proc Natl Acad Sci U S A 103:16319-24. 2006
    ..These data establish Sall4 as an essential transcription factor required for the early development of inner cell mass-derived cell lineages...
  95. ncbi HOP/NECC1, a novel regulator of mouse trophoblast differentiation
    Kazuo Asanoma
    Division of Molecular and Cell Therapeutics, Kyushu University, Japan
    J Biol Chem 282:24065-74. 2007
    ....
  96. ncbi PIAS proteins as repressors of Oct4 function
    Elena Tolkunova
    Department of Developmental Biology, Max Planck Institute for Immunobiology, Stubeweg 51, 79108 Freiburg, Germany
    J Mol Biol 374:1200-12. 2007
    ..We propose that Oct4 inhibition, mediated by this new class of transcriptional partners, might be instrumental during mammalian development...
  97. ncbi Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression
    Yusuke Seino
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 283:4905-11. 2008
    ..These data suggest that Isx participates in the maintenance of vitamin A metabolism by regulating Bcmo1 expression in the intestine...
  98. pmc SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages
    Shang Yi Chiu
    Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    PLoS Biol 6:e310. 2008
    ..Our data reveal a key genetic pathway, SENP2-Mdm2-p53, underlying trophoblast lineage development, suggesting its pivotal role in cell cycle progression of mitosis and endoreduplication...
  99. pmc Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension
    Xianling Zhao
    Burnham Institute for Medical Research, Development and Aging Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Gene Expr Patterns 9:430-5. 2009
    ..Sprouty2 and Pea3 expression, and an expansion of Wnt/beta-catenin signaling detected by expression of Axin2, Tbx6, Cdx2, and Cdx4...
  100. pmc Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis
    Jianhua Chu
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    Dev Biol 342:63-73. 2010
    ..Our results indicate that both Cripto and Cryptic function non-cell-autonomously during normal development, and that most if not all Nodal activity in early mouse embryogenesis is EGF-CFC-dependent...
  101. pmc Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo
    Kashif Ahmed
    Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS ONE 5:e10531. 2010
    ..Together, these studies show that an open chromatin architecture is established in the embryonic lineages during development and is sufficient to distinguish pluripotent cells from tissue-restricted progenitor cells...

Research Grants13

  1. Molecular Mechanisms Underlying Barrett's Esophagus
    Debra Silberg; Fiscal Year: 2003
    ....
  2. Cdx in GI Differentiation and Transdifferentiation
    Debra Silberg; Fiscal Year: 2005
    ..The origin of this important human premalignant lesion is unknown but of clear clinical relevance. CDX1 and CDX2, intestine specific homeobox transcription factors, are candidate genes for directing development, differentiation ..
  3. REGULATION OF CDX GENE EXPRESSION IN COLON CANCER
    Eunran Suh; Fiscal Year: 2002
    ..CDX1 and CDX2 are transcription factors that are involved in regulation of proliferation and differentiation of the intestinal ..
  4. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  5. REGULATION OF INTESTINAL EPITHELIAL CELL PROLIFERATION
    John Lynch; Fiscal Year: 2004
    ..The caudal-related genes, CDX1 and CDX2, are known to be required for the correct developmental expression of several intestine-specific genes, including ..
  6. REGULATION OF INTESTINE-SPECIFIC GENE TRANSCRIPTION
    Eunran Suh; Fiscal Year: 2006
    ..Cdx1 and Cdx2 were shown to be key factors in the transcriptional regulation of a number of intestine specific genes...
  7. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  8. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  9. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  10. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  11. Cdx2 modulates beta-catenin activity in intestinal cells
    John P Lynch; Fiscal Year: 2010
    ..The homeodomain transcription factor Cdx2 is a well-studied regulator of intestine-specific gene expression...