Cdkn1c

Summary

Gene Symbol: Cdkn1c
Description: cyclin-dependent kinase inhibitor 1C (P57)
Alias: AL024410, CDKI, Kip2, p57(kip2), p57Kip2, cyclin-dependent kinase inhibitor 1C, cyclin-dependent kinase inhibitor p57
Species: mouse

Top Publications

  1. ncbi The Ankrd2, Cdkn1c and calcyclin genes are under the control of MyoD during myogenic differentiation
    Camilla Bean
    Dipartimento di Biologia and CRIBI Biotechnology Centre, Universita degli Studi di Padova, 35121 Padova, Italy
    J Mol Biol 349:349-66. 2005
  2. ncbi A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topography
    Laura Croci
    San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Development 133:2719-29. 2006
  3. ncbi The expression of Cdk inhibitors p27kip1 and p57kip2 in mouse placenta and human choriocarcinoma JEG-3 cells
    S T Kim
    Department of Obstetrics and Gynecology, Konyang University Hospital, Daejeon 302 241, Republic of Korea
    Placenta 26:73-80. 2005
  4. ncbi Notch 1 inhibits photoreceptor production in the developing mammalian retina
    Ashutosh P Jadhav
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 133:913-23. 2006
  5. pmc Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex
    Georges Mairet-Coello
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Neurosci 29:775-88. 2009
  6. ncbi Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5
    M Paulsen
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Hum Mol Genet 7:1149-59. 1998
  7. ncbi Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting
    S Engemann
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195 Berlin, Germany
    Hum Mol Genet 9:2691-706. 2000
  8. pmc The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes
    Helen E MacLean
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 113:1334-43. 2004
  9. pmc The imprinted Phlda2 gene regulates extraembryonic energy stores
    S J Tunster
    Genetics Division, Cardiff School of Biosciences, Cardiff University, Cardiff, Wales CF10 3AX, United Kingdom
    Mol Cell Biol 30:295-306. 2010
  10. ncbi Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor, in mouse
    I Hatada
    National Cardiovascular Center Research Institute, Osaka, Japan
    Nat Genet 11:204-6. 1995

Research Grants

  1. 6th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2006
  2. 5TH INTERNATIONAL PODOCYTE CONFERENCE
    Stuart Shankland; Fiscal Year: 2004
  3. MECHANISMS OF PODOCYTE INJURY
    Stuart Shankland; Fiscal Year: 2005
  4. Regulation of parietal bone differentiation
    Venkatesh Govindarajan; Fiscal Year: 2007
  5. CELL CYCLE CONTROL IN GLOMERULAR DISEASE
    Stuart Shankland; Fiscal Year: 2007
  6. 7th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2008
  7. Molecular Regulation of Ocular Gland Development
    Venkatesh Govindarajan; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications116 found, 100 shown here

  1. ncbi The Ankrd2, Cdkn1c and calcyclin genes are under the control of MyoD during myogenic differentiation
    Camilla Bean
    Dipartimento di Biologia and CRIBI Biotechnology Centre, Universita degli Studi di Padova, 35121 Padova, Italy
    J Mol Biol 349:349-66. 2005
    ..Among these genes, we concentrated our study on the cell cycle regulators Cdkn1c and calcyclin and on the muscle-specific putative myogenic regulator Ankrd2...
  2. ncbi A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topography
    Laura Croci
    San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Development 133:2719-29. 2006
    ....
  3. ncbi The expression of Cdk inhibitors p27kip1 and p57kip2 in mouse placenta and human choriocarcinoma JEG-3 cells
    S T Kim
    Department of Obstetrics and Gynecology, Konyang University Hospital, Daejeon 302 241, Republic of Korea
    Placenta 26:73-80. 2005
    This study was to investigate the expression of Cdk inhibitors p27kip1 and p57kip2 during the development of mouse placenta and during the steroid-treated culture of human choriocarcinoma JEG-3 cells...
  4. ncbi Notch 1 inhibits photoreceptor production in the developing mammalian retina
    Ashutosh P Jadhav
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 133:913-23. 2006
    ..These cone enriched mutant mice should prove to be a valuable resource for the study of this relatively rare mammalian photoreceptor cell type...
  5. pmc Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex
    Georges Mairet-Coello
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Neurosci 29:775-88. 2009
    ..Moreover, p27(KIP1) and p57(KIP2) expression were reduced, suggesting downregulation of negative regulators contributes to mitogenesis...
  6. ncbi Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5
    M Paulsen
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Hum Mol Genet 7:1149-59. 1998
    ..We also localized Kcnq1 (Kvlqt1) and Cd81 (Tapa-1) between Cdkn1c (p57(Kip2)) and Mash2...
  7. ncbi Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting
    S Engemann
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195 Berlin, Germany
    Hum Mol Genet 9:2691-706. 2000
    ..5. Here we focus on the adjacent sequences of 0.5 Mb including the KCNQ1/Kcnq1 and CDKN1C/Cdkn1c genes, which are implicated in BWS, and on one of the proposed boundary regions of the imprinting cluster...
  8. pmc The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes
    Helen E MacLean
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 113:1334-43. 2004
    ..Because the bone phenotype of mice lacking the cyclin-dependent kinase inhibitor p57(Kip2) is the opposite of the PTHrP-null phenotype, we hypothesized that PTHrP's proliferative actions in chondrocytes ..
  9. pmc The imprinted Phlda2 gene regulates extraembryonic energy stores
    S J Tunster
    Genetics Division, Cardiff School of Biosciences, Cardiff University, Cardiff, Wales CF10 3AX, United Kingdom
    Mol Cell Biol 30:295-306. 2010
    ....
  10. ncbi Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor, in mouse
    I Hatada
    National Cardiovascular Center Research Institute, Osaka, Japan
    Nat Genet 11:204-6. 1995
    b>p57KIP2 is a potent tight-binding inhibitor of several G1 cyclin/Cdk complexes, and is a negative regulator of cell proliferation. The gene encoding human p57KIP is located on chromosome 11p15.5 (ref...
  11. ncbi Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
    M H Lee
    Cell Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 9:639-49. 1995
    ..We have isolated a new member of the p21CIP1/p27KIP1 CDI family and named it p57KIP2 to denote its apparent molecular mass and higher similarity to p27KIP1...
  12. ncbi p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene
    S Matsuoka
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 9:650-62. 1995
    ..We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1...
  13. ncbi Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development
    Y Yan
    Department of Molecular Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Genes Dev 11:973-83. 1997
    p57(Kip2) is a paternally imprinted gene that encodes a potent inhibitor of several cyclin/Cdk complexes...
  14. ncbi Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome
    P Zhang
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 387:151-8. 1997
    Mice lacking the imprinted Cdk inhibitor p57(KIP2) have altered cell proliferation and differentiation, leading to abdominal muscle defects; cleft palate; endochondral bone ossification defects with incomplete differentiation of ..
  15. ncbi New p57KIP2 mutations in Beckwith-Wiedemann syndrome
    I Hatada
    National Cardiovascular Center Research Institute, Osaka, Japan
    Hum Genet 100:681-3. 1997
    ..Previously, we found p57KIP2, which is a Cdk-kinase inhibitor located at 11p15, is mutated in two BWS patients...
  16. ncbi Imprinting of mouse Kvlqt1 is developmentally regulated
    T D Gould
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Building 6B, Room 2B206, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Hum Mol Genet 7:483-7. 1998
    ..Late juvenile and adult animals show complete biallelism, suggesting an explanation for the lack of parent of origin bias in JLN and long QT...
  17. ncbi The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis
    P Riley
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nat Genet 18:271-5. 1998
    ..Their heart tubes showed abnormal looping and ventricular myocardial differentiation. Therefore, Hand1 is essential for differentiation of both trophoblast and cardiomyocytes, which are embryologically distinct cell lineages...
  18. pmc Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster
    T Caspary
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Mol Cell Biol 18:3466-74. 1998
    ..end of mouse chromosome 7 that contains a cluster of four maternally expressed genes, H19, Mash2, Kvlqt1, and p57(Kip2), as well as two paternally expressed genes, Igf2 and Ins2, and assess the expression and imprinting of Mash2, ..
  19. pmc Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development
    P Zhang
    Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York 10461 USA
    Genes Dev 12:3162-7. 1998
    ..In this study, using multiple mutant mice, we show that the Cdk inhibitors p27(KIP1) and p57(KIP2) function redundantly to control cell cycle exit and differentiation of lens fiber cells and placental trophoblasts...
  20. pmc p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step
    P Zhang
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 13:213-24. 1999
    ..Here we show that two Cdk inhibitors, p21(CIP1) and p57(KIP2), redundantly control differentiation of skeletal muscle and alveoli in the lungs...
  21. ncbi Prox1 function is crucial for mouse lens-fibre elongation
    J T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Genet 21:318-22. 1999
    ..downregulated expression of the cell-cycle inhibitors Cdkn1b (also known as p27KIP1) and Cdkn1c (also known as p57KIP2), misexpression of E-cadherin and inappropriate apoptosis...
  22. ncbi p57Kip2 expression is enhanced during mid-cardiac murine development and is restricted to trabecular myocardium
    L K Kochilas
    Division of Pediatric Cardiology, Children s Hospital of Philadelphia, Pennsylvania, USA
    Pediatr Res 45:635-42. 1999
    ..One of the genes that we identified, p57Kip2, encodes a cyclin-dependent kinase inhibitor of the p21 family...
  23. ncbi A human p57(KIP2) transgene is not activated by passage through the maternal mouse germline
    R M John
    Wellcome CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QR, UK
    Hum Mol Genet 8:2211-9. 1999
    ..and the syntenic region on mouse distal chromosome 7, contain several imprinted genes, including p57 (KIP2) ( CDKN1C ) and IGF2...
  24. pmc Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome
    T Caspary
    Howard Hughes Medical Institute, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 13:3115-24. 1999
    ..5. A subset of BWS patients has been identified with loss-of-function mutations in p57(KIP2), a maternally expressed gene encoding a G(1) cyclin-dependent kinase inhibitor...
  25. pmc A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle
    A Blixt
    Department of Molecular Biology, Goteborg University, The Lundberg Laboratory, Medicinaregatan 9C, Box 462, S 405 30 Goteborg, Sweden
    Genes Dev 14:245-54. 2000
    ..This implies that FoxE3 is essential for closure of the lens vesicle and is a factor that promotes survival and proliferation, while preventing differentiation, in the lens epithelium...
  26. ncbi Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7
    R Kato
    Department of Integrated Genetics, National Institute of Genetics and Graduate University for Advanced Studies, Mishima, Shizuoka, Japan
    DNA Res 6:401-5. 1999
    ....
  27. ncbi Mice lacking a CDK inhibitor, p57Kip2, exhibit skeletal abnormalities and growth retardation
    K Takahashi
    Molecular Oncology Group, Nippon Roche Research Center, Kajiwara, Kamakura, Kanagawa 247 0063, Japan
    J Biochem 127:73-83. 2000
    b>p57Kip2, one of the cyclin-dependent kinase (CDK) inhibitors, has been suggested to be a tumor suppressor candidate. To elucidate its biological roles in mouse development and tumorigenesis, we created p57Kip2-deficient mice...
  28. ncbi p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina
    M A Dyer
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 127:3593-605. 2000
    ..We have found that the p57(Kip2) cyclin kinase inhibitor is upregulated during G(1)/G(0) in a subset of retinal progenitor cells exiting the cell ..
  29. ncbi Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain
    P Onyango
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genome Res 10:1697-710. 2000
    ..This study provides the first global view of the architecture of an entire imprinted domain and provides candidate sequence elements for subsequent functional analyses...
  30. ncbi Distant cis-elements regulate imprinted expression of the mouse p57( Kip2) (Cdkn1c) gene: implications for the human disorder, Beckwith--Wiedemann syndrome
    R M John
    Wellcome CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QR, UK
    Hum Mol Genet 10:1601-9. 2001
    ..Only two of these genes, p57(KIP2) (CDKN1C) and IGF2, are likely to be functionally involved in this disease...
  31. ncbi Dynamic temporal and spatial regulation of the cdk inhibitor p57(kip2) during embryo morphogenesis
    J Westbury
    School of Biological Sciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    Mech Dev 109:83-9. 2001
    The complete developmental expression pattern of the cyclin dependent kinase inhibitor (CDKI) p57(kip2) has not been reported, here we report a detailed study of the localization of p57(kip2) protein during mouse organogenesis...
  32. pmc Induction of p57(KIP2) expression by p73beta
    Eva Balint
    Regulation of Cell Growth Laboratory, Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, MD 21702 1201, USA
    Proc Natl Acad Sci U S A 99:3529-34. 2002
    ..Our results suggest that p73 may regulate expression of genes through mechanisms that are not shared by p53, potentially explaining the different contributions of p53 and p73 to normal development...
  33. pmc Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation
    Takumi Kamura
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 100:10231-6. 2003
    The abundance of the cyclin-dependent kinase (CDK) inhibitor p57Kip2, an important regulator of cell cycle progression, is thought to be controlled by the ubiquitin-proteasome pathway...
  34. ncbi p57KIP2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein Kinase
    Tong Shin Chang
    National Creative Research Initiative Center for Cell Death, School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    J Biol Chem 278:48092-8. 2003
    b>p57KIP2, a member of the Cip/Kip family of enzymes that inhibit several cyclin-dependent kinases, plays a role in many biological events including cell proliferation, differentiation, apoptosis, tumorigenesis and developmental changes...
  35. pmc BMP10 is essential for maintaining cardiac growth during murine cardiogenesis
    Hanying Chen
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 131:2219-31. 2004
    ..BMP10 null mice display ectopic and elevated expression of p57(kip2) and a dramatic reduction in proliferative activity in cardiomyocytes at E9.0-E9.5...
  36. ncbi Placental growth retardation due to loss of imprinting of Phlda2
    Martha Salas
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Mech Dev 121:1199-210. 2004
    The maternally expressed/paternally silenced genes Phlda2 (a.k.a. Ipl/Tssc3), Slc22a1l, Cdkn1c, Kcnq1, and Ascl2 are clustered in an imprinted domain on mouse chromosome 7...
  37. ncbi Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation
    Annabelle Lewis
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Nat Genet 36:1291-5. 2004
    ....
  38. ncbi Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes
    David Umlauf
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, 1919, route de Mende, 34090 Montpellier, France
    Nat Genet 36:1296-300. 2004
    ....
  39. ncbi The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster
    Flavia Cerrato
    Dipartimento di Scienze Ambientali, Seconda Universita di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Hum Mol Genet 14:503-11. 2005
    ..However, the mechanisms by which imprinting of genes in the IC2 domain (e.g. Cdkn1c and Kcnq1) is regulated have not been well defined, and recent evidence indicates that distantly located cis-..
  40. pmc Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes
    Debora Mancini-DiNardo
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 20:1268-82. 2006
    ..genes encoding the maternally expressed placental-specific transcription factor ASCL2, the cyclin-dependent kinase CDKN1C, and the potassium channel KCNQ1...
  41. ncbi p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors
    Senta Georgia
    Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Dev Biol 298:22-31. 2006
    ....
  42. ncbi Origin and characteristics of glycogen cells in the developing murine placenta
    P M Coan
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge, United Kingdom
    Dev Dyn 235:3280-94. 2006
    ..Thus stereology and immunohistochemistry have provided useful insights into Jz development and function of the glycogen cells...
  43. ncbi The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex
    Yasuhiro Itoh
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 282:390-6. 2007
    ..These results suggest that both p57 and p27 play essential roles in neuronal migration and may, in concert, coordinate the timing of neuronal differentiation, migration, and possibly cell cycle arrest in neocortical development...
  44. pmc A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord
    Hongxing Gui
    Department of Neuroscience and Cell Biology, Program in Neuroscience, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Dev Biol 301:14-26. 2007
    ..and post-mitotic neurons during early neurogenesis, with p27(Kip1) having the broadest expression, and both p57(Kip2) and p21(Cip1) showing transient expression in restricted populations...
  45. pmc Two distinct mechanisms of silencing by the KvDMR1 imprinting control region
    Jong Yeon Shin
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    EMBO J 27:168-78. 2008
    ..in the loss of imprinted expression of these genes in the placenta, it does not affect imprinted expression of Cdkn1c in a subset of embryonic tissues despite universal loss of paternal-specific methylation at Cdkn1c...
  46. doi Differential requirement for beta-catenin in epithelial and fiber cells during lens development
    Sarah Cain
    Ocular Development Laboratory, Anatomy and Cell Biology Department, University of Melbourne, Victoria 3010, Australia
    Dev Biol 321:420-33. 2008
    ..epithelial layer with loss of E-cadherin and Pax6 expression as well as abnormal expression of c-Maf and p57(kip2) but not Prox1...
  47. pmc The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing
    Lisa Redrup
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
    Development 136:525-30. 2009
    ..Long ncRNAs in imprinting clusters and the Xist RNA on the inactive X chromosome thus appear to regulate epigenetic gene silencing by similar mechanisms...
  48. pmc Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model
    Etsuo Susaki
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 106:5192-7. 2009
    ..Thus, these observations indicate that p57 and p27 share many characteristics in vivo, but that p57 also performs specific functions not amenable to substitution with p27...
  49. pmc The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens
    Luke A Wiley
    Departments of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, USA
    Invest Ophthalmol Vis Sci 51:3611-8. 2010
    ..The lens provides an assay system to identify pathways critical for fiber cell differentiation and to test therapies for the tumors that occur in patients with NF2...
  50. doi Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1
    Faizaan Mohammad
    Department of Genetics and Pathology, Dag Hammarskjölds väg 20, 75185 Rudbeck Laboratory, Uppsala University, Uppsala 75185, Sweden
    Development 137:2493-9. 2010
    ....
  51. doi p57(Kip2) and cancer: time for a critical appraisal
    Adriana Borriello
    Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy
    Mol Cancer Res 9:1269-84. 2011
    ..molecular studies on animal models and patients with Beckwith-Wiedemann syndrome have shown that alterations in CDKN1C (the p57(Kip2) encoding gene) have functional relevance in the pathogenesis of this disease...
  52. doi p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70
    Peng Zou
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 9:247-61. 2011
    ..Taken together, these data suggest that regulation of cytoplasmic localization of Hsc70/cyclin D1 complex by p57 and p27 is a key intracellular mechanism in controlling HSC dormancy...
  53. doi p57 is required for quiescence and maintenance of adult hematopoietic stem cells
    Akinobu Matsumoto
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582, Japan
    Cell Stem Cell 9:262-71. 2011
    ..Our results therefore suggest that, among Cip/Kip family CDK inhibitors, p57 plays a predominant role in the quiescence and maintenance of adult HSCs...
  54. pmc Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development
    Tien T Le
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Dev Dyn 241:493-504. 2012
    ..However, Notch signaling appears to play no obvious role during lens induction or morphogenesis, although multiple pathway genes are expressed at these earlier stages...
  55. pmc Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation
    Christine L Kerr
    Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
    Invest Ophthalmol Vis Sci 53:3316-30. 2012
    ..Hedgehog signaling is implicated in eye development, and defects in hedgehog signaling components have been shown to result in defects of the retina, iris, and lens...
  56. doi Development of mice without Cip/Kip CDK inhibitors
    Yuki Tateishi
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Fukuoka, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 427:285-92. 2012
    ....
  57. pmc The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart
    Lisa Korostowski
    Fels Institute for Cancer Research Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 8:e1002956. 2012
    ..Production of Kcnq1ot1 on the maternal chromosome does not silence Cdkn1c. We find that in later developmental stages, however, Kcnq1ot1 has a role in modulating Kcnq1 levels, since its ..
  58. ncbi p57(Kip2) regulates the proper development of labyrinthine and spongiotrophoblasts
    K Takahashi
    Molecular Oncology Group, Nippon Roche Research Center 200, Kajiwara, Kamakura, Kanagawa 247 8530, Japan
    Mol Hum Reprod 6:1019-25. 2000
    The cyclin-dependent kinase (cdk) inhibitor, p57 (Kip2) is a tumour suppressor candidate and a paternally-imprinted gene. In humans, the p57(Kip2) gene is located on chromosome 11p15...
  59. ncbi p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations
    M A Dyer
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:4259-71. 2001
    ..During the embryonic stages of development, when both p27(Kip1) and p57(Kip2) are expressed in retinal progenitor cells, they were found in distinct populations, demonstrating directly that ..
  60. ncbi Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1
    Galina V Fitzpatrick
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Genet 32:426-31. 2002
    ..show that paternal inheritance of a deletion of KvDMR1 results in the de-repression in cis of six genes, including Cdkn1c, which encodes cyclin-dependent kinase inhibitor 1C...
  61. ncbi Deficiency in p57Kip2 expression induces preeclampsia-like symptoms in mice
    Naohiro Kanayama
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine 3600, Handa Cho, Hamamatsu, Shizuoka 431 3192, Japan
    Mol Hum Reprod 8:1129-35. 2002
    b>p57Kip2, a potent inhibitor of several cyclin/cyclin dependent kinase complexes (CDK ), is a paternally imprinted gene in both humans and mice, and here we show that pregnant mice which are heterozygous for p57Kip2 deficiency display ..
  62. pmc p57(Kip2) cooperates with Nurr1 in developing dopamine cells
    Bertrand Joseph
    The Ludwig Institute for Cancer Research, Box 240, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:15619-24. 2003
    ..Here we show that p57Kip2 is expressed in postmitotic differentiating midbrain dopamine cells...
  63. pmc Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7
    Stuart C Andrews
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    BMC Dev Biol 7:53. 2007
    b>Cdkn1c encodes an embryonic cyclin-dependant kinase inhibitor that acts to negatively regulate cell proliferation and, in some tissues, to actively direct differentiation...
  64. pmc Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation
    Haotian Zhao
    Graduate Program in Molecular, Cellular and Developmental Biology, College of Biological Sciences, The Ohio State University, Columbus, OH 43210, USA
    Dev Biol 318:276-88. 2008
    ..proliferation in prospective lens fiber cells, reduced expression of the cell cycle inhibitors p27(kip1) and p57(kip2), increased apoptosis and aberrant or reduced expression of Prox1, Pax6, c-Maf, E-cadherin and alpha-, beta- and ..
  65. ncbi Spatial and temporal expression of p57(KIP2) during murine lens development
    F J Lovicu
    Department of Anatomy and Histology and Institute for Biomedical Research F13, The University of Sydney, NSW 2006, Australia
    Mech Dev 86:165-9. 1999
    The expression patterns of p57(KIP2), an important cyclin-dependent kinase inhibitor in the lens, is investigated...
  66. doi H19 acts as a trans regulator of the imprinted gene network controlling growth in mice
    Anne Gabory
    Genetics and Development Department, INSERM U567, CNRS UMR 8104, University of Paris Descartes, Institut Cochin, Paris, France
    Development 136:3413-21. 2009
    ..Our results also bring further experimental evidence for the existence of the IGN and open new perspectives in the comprehension of the role of genomic imprinting in embryonic growth and in human imprinting pathologies...
  67. pmc Increased IGF-II protein affects p57kip2 expression in vivo and in vitro: implications for Beckwith-Wiedemann syndrome
    V Grandjean
    University of Cambridge, Department of Anatomy, Downing Street, CB2 3DY Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 97:5279-84. 2000
    ..Human and mouse genetic data strongly implicate another gene, CDKN1C (p57(kip2)), located in the same imprinted gene cluster on human chromosome II, in BWS...
  68. pmc RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex
    Shinobu Hirai
    Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    EMBO J 31:1190-202. 2012
    ..These findings establish RP58 as a novel key regulator that controls the self-renewal and differentiation of NSCs and restriction of astrogenesis by repressing all Id genes during corticogenesis...
  69. ncbi p57KIP2 targeted disruption and Beckwith-Wiedemann syndrome: is the inhibitor just a contributor?
    W J Swanger
    Fred Hutchinson Cancer Research Center, Seattle, WA 98107, USA
    Bioessays 19:839-42. 1997
    ..Genetic evidence has suggested a role for p57KIP2, a member of a family of cell cycle inhibitory genes, in Beckwith-Wiedemann syndrome...
  70. ncbi Developmental potential of mouse primordial germ cells
    Y Kato
    Wellcome CRC Institute of Cancer and Developmental Biology and Physiological Laboratory, Tennis Court Road, University of Cambridge, Cambridge CB2 1QR, UK
    Development 126:1823-32. 1999
    ..The evidence suggests that gametic imprints are essential for normal development, and that they can neither be initiated nor erased in mature oocytes; these properties are unique to the developing germ line...
  71. ncbi Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family
    T Enklaar
    Children s Hospital, University of Mainz, Langenbeckstrasse 1, Mainz, D 55101, Germany
    Genomics 67:179-87. 2000
    ..Imprinting analysis, using RT-PCR on RNA from reciprocal mouse crosses harboring a sequence polymorphism, revealed biallelic expression of Mtr1 transcripts at all stages and tissues examined...
  72. ncbi Proliferation in the posterior region of the lens of c-maf-/- mice
    K Yoshida
    Department of Ophthalmology, Hokkaido University School of Medicine, Kita ku, Sapporo, Japan
    Curr Eye Res 23:116-9. 2001
    ..To examine the involvement of the c-maf gene in the proliferation of the lens cells...
  73. ncbi Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation
    Bin Wang
    Department of Molecular Genetics and The Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Development 131:4477-87. 2004
    ....
  74. pmc Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system
    Friedrich Laub
    Laboratory of Genetics and Organogenesis, Research Division of the Hospital for Special Surgery, and Department of Physiology and Biophysics at Weill Medical College of Cornell University, 535 East 70th St, New York, New York 10021, USA
    Mol Cell Biol 25:5699-711. 2005
    ..KLF7 activity might therefore control neuronal morphogenesis in part by optimizing the levels of molecules that promote axon outgrowth...
  75. pmc Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development
    Michael A Gonzalez
    Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, UK
    Genes Dev 20:1880-4. 2006
    ..Geminin is also down-regulated in TGCs of wild-type blastocysts during S and gap-like phases by proteasome-mediated degradation, suggesting that loss of geminin is part of the mechanism regulating endoreduplication...
  76. pmc The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression
    Junling Jia
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:7236-47. 2007
    ..We found that the Notch effector Herp2 is expressed in lens epithelium and directly suppresses p57Kip2 expression, providing a molecular link between Notch signaling and the cell cycle control machinery during lens ..
  77. pmc C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57
    Makoto Hirata
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 4:e4543. 2009
    ..This study investigated the role of the transcription factor CCAAT/enhancer-binding protein beta (C/EBPbeta) in chondrocytes during endochondral ossification...
  78. pmc Postnatal survival of mice with maternal duplication of distal chromosome 7 induced by a Igf2/H19 imprinting control region lacking insulator function
    Li Han
    Division of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
    PLoS Genet 6:e1000803. 2010
    ..size could involve inactivity of Igf2, encoding a growth factor, with some contribution by over-expression of Cdkn1c, encoding a negative growth regulator. Mice lacking Igf2 expression are usually viable, and MatDup...
  79. pmc Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development
    Aurore Carre
    INSERM U845, Universite Paris Descartes, Paris, France
    PLoS ONE 6:e16752. 2011
    ....
  80. pmc The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors
    So Yoon Kim
    Regenerative Biology Section, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 138:1903-12. 2011
    ....
  81. pmc The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens
    Luke A Wiley
    Department of Ophthalmology and Visual Sciences, Washington University, Saint Louis, MO 63110, USA
    Dis Model Mech 4:484-95. 2011
    ..Acvr1 acts as a tumor suppressor in the lens. Enhancing p53 function in the lens could contribute to the prevention of steroid- and radiation-induced posterior subcapsular cataracts...
  82. pmc A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner
    H Bastian
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, FRG
    EMBO J 9:1839-52. 1990
    ....
  83. ncbi Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome
    W Reik
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, UK
    Trends Genet 13:330-4. 1997
    ..In addition, the precise phenotypic spectrum of BWS might depend on which maternally expressed gene is mutated...
  84. ncbi The imprinted domain in mouse distal Chromosome 7: reagents for mutagenesis and sequencing
    C D Day
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mamm Genome 10:182-5. 1999
  85. ncbi Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and huma
    H Yatsuki
    Department of Biochemistry, Saga Medical School, Saga, Japan
    DNA Res 7:195-206. 2000
    ..Further characterization of this locus based on the sequence comparison between mouse and human will contribute valuable information towards resolving the mechanism of the occurrence of BWS and the associated childhood tumor...
  86. ncbi Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development
    H Nagahama
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Anat Embryol (Berl) 203:77-87. 2001
    The cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 are thought to regulate progression of the cell cycle...
  87. ncbi Age-dependent changes of p57(Kip2) and p21(Cip1/Waf1) expression in skeletal muscle and lung of mice
    C W Park
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 305 701, Taejon, South Korea
    Biochim Biophys Acta 1520:163-8. 2001
    p57(Kip2) and p21(Cip1/Waf1) are members of cyclin-dependent kinase (Cdk) inhibitors which play critical roles in the terminal differentiation of skeletal muscle and lung...
  88. pmc Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
    E Schipani
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Genes Dev 15:2865-76. 2001
    ....
  89. pmc Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype
    Guy Goudreau
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 99:8719-24. 2002
    ..Our findings thus provide a mechanism implicating gene regulatory interactions between Pax6 and Six3 in the tissue-specific defects found in Pax6 heterozygous mice...
  90. pmc Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH
    Nicola L Mahy
    MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    J Cell Biol 159:753-63. 2002
    ..This is shown to be partly dependent on ongoing transcription. We suggest that local gene density and transcription, rather than the activity of individual genes, influences the organization of chromosomes in the nucleus...
  91. ncbi Microarray analysis of uterine gene expression in mouse and human pregnancy
    Kathleen E Bethin
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Endocrinol 17:1454-69. 2003
    ....
  92. ncbi Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb
    Qin Chen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:17667-73. 2004
    ....
  93. ncbi Identification of multiple cell cycle regulatory functions of p57Kip2 in human T lymphocytes
    Guiming Li
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 173:2383-91. 2004
    The specific functions of p57(Kip2) in lymphocytes have not yet been fully elucidated...
  94. ncbi Lsh controls silencing of the imprinted Cdkn1c gene
    Tao Fan
    Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Development 132:635-44. 2005
    ..We report here that loss of Lsh specifically alters expression of the Cdkn1c gene (also known as p57(Kip2)) but does not interfere with maintenance of imprints at the H19, Igf2, Igf2r, Zac1 ..
  95. ncbi Inactivation of imprinted genes induced by cellular stress and tumorigenesis
    Cristina Pantoja
    Spanish National Cancer Center, Madrid, Spain
    Cancer Res 65:26-33. 2005
    ..a novel phenomenon that consists of the rapid and coordinated silencing of genes subject to imprinting, including Cdkn1c, Igf2, H19, Ndn1, Grb10, and Meg3...
  96. ncbi Expression of cell cycle-related proteins in developing and adult mouse hippocampus
    Stefanie Schmetsdorf
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Int J Dev Neurosci 23:101-12. 2005
    ..expression and activation of regulatory proteins like cyclin dependent kinases (cdk), cyclins, or cdk inhibitors (cdki). In postmitotic and terminally differentiated neurons, cell cycle activity is arrested by enrichment of cdkis...
  97. ncbi Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Curr Eye Res 30:437-42. 2005
    ..The purpose of this study was to examine the correlation between the expression of p27(KIP1) and cell proliferation in the lens cells after the extraction of lens fiber cells...
  98. ncbi Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development
    Serge Nef
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    Dev Biol 287:361-77. 2005
    ..The cyclin-dependent kinase inhibitors Cdkn1a and Cdkn1c are overexpressed in XX gonads at E11.5 and E12...
  99. ncbi Genomic imprinting in Dicer1-hypomorphic mice
    M Fukasawa
    Biosignal Genome Resource Center, Department of Molecular and Cellular Biology, Gunma University, Maebashi, Japan
    Cytogenet Genome Res 113:138-43. 2006
    ..We did not observe any abnormality in the allelic expression of imprinted genes in these mice or their offspring, suggesting that reduced expression of Dicer1 did not significantly affect the maintenance and reprogramming of imprinting...
  100. pmc Compensation by tumor suppressor genes during retinal development in mice and humans
    Stacy L Donovan
    Department of Developmental Neurobiology, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    BMC Biol 4:14. 2006
    ..In this manuscript, we explore the different roles of the Rb family in human and mouse retinal development in order to better understand the species-specific difference in retinoblastoma susceptibility...
  101. ncbi The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors
    Abeer El Wakil
    UMR CNRS 7000, Cytosquelette et Développement, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Development 133:2155-65. 2006
    ..Hence, our data have provided evidence for the ability of Gata2 to inhibit the proliferation of neural progenitors, and they further suggest that, in this regard, Gata2 can operate independently of neuronal differentiation...

Research Grants7

  1. 6th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2006
    ..Moreover, this is an exciting era in podocytes biology given the large body of literature that has been published in the past 2-5 years. [unreadable] [unreadable] [unreadable]..
  2. 5TH INTERNATIONAL PODOCYTE CONFERENCE
    Stuart Shankland; Fiscal Year: 2004
    ..3. To facilitate cross-talk between clinicians and scientists with the ultimate goal of improving prognosis, treatment and care of patients with glomerular disease. ..
  3. MECHANISMS OF PODOCYTE INJURY
    Stuart Shankland; Fiscal Year: 2005
    ..Taken together, the overall goal is to show novel mechanisms underlying podo injury, so that ultimately, specific therapeutic strategies can be developed to reduce podo injury in the development of glomerular sclerosis. ..
  4. Regulation of parietal bone differentiation
    Venkatesh Govindarajan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. CELL CYCLE CONTROL IN GLOMERULAR DISEASE
    Stuart Shankland; Fiscal Year: 2007
    ..The ultimate goal is to identify new targets for potential therapies in order to reduce the heavy burden of disease in patients with gIomerular disease. ..
  6. 7th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2008
    ..In summary, the only hope for our patients is by focused and concerted efforts such as the 7th International Podocyte Conference which will ultimately enhance their overall care. [unreadable] [unreadable] [unreadable]..
  7. Molecular Regulation of Ocular Gland Development
    Venkatesh Govindarajan; Fiscal Year: 2010
    ..In addition, the proposed studies will, in the long-term, allow the development of novel therapeutic approaches for treatment of patients with dry eye syndromes. ..