Cdkn1a

Summary

Gene Symbol: Cdkn1a
Description: cyclin-dependent kinase inhibitor 1A (P21)
Alias: CAP20, CDKI, CIP1, Cdkn1, P21, SDI1, Waf1, mda6, p21Cip1, p21WAF, cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, melanoma differentiation-associated protein
Species: mouse

Top Publications

  1. pmc p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells
    J Brugarolas
    Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Cell Biol 141:503-14. 1998
  2. ncbi Heterozygosity of p21WAF1/CIP1 enhances tumor cell proliferation and cyclin D1-associated kinase activity in a murine mammary cancer model
    J M Jones
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell Growth Differ 10:213-22. 1999
  3. ncbi The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development
    D Balomenos
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Cantoblanco, E 28049 Madrid, Spain
    Nat Med 6:171-6. 2000
  4. ncbi p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export
    Jodi R Alt
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 277:8517-23. 2002
  5. ncbi Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis
    Aksam J Merched
    Department of Molecular, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Circulation 110:3830-41. 2004
  6. ncbi Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    C Deng
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 82:675-84. 1995
  7. ncbi Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    T Cheng
    Experimental Hematology, AIDS Research Center, Massachusetts General Hospital Cancer Center, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Science 287:1804-8. 2000
  8. ncbi p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells
    S B Parker
    Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
    Science 267:1024-7. 1995
  9. pmc p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus
    Robert N Pechnick
    Department of Medicine, Division of Endocrinology, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 105:1358-63. 2008
  10. pmc p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step
    P Zhang
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 13:213-24. 1999

Research Grants

  1. Role of fractalkine signaling in rheumatoid arthritis
    James Woods; Fiscal Year: 2004
  2. TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURY
    MICHAEL O REILLY; Fiscal Year: 2002
  3. P21 transcriptional inhibitors as proapoptotic compounds
    Andrei Gartel; Fiscal Year: 2003
  4. COORDINATE REGULATION OF APOPTOSIS AND CELL CYCLE IN RA
    Harris Perlman; Fiscal Year: 2004
  5. The role BH3 and multi BH domain genes in regulating monocyte survival and functi
    Harris Perlman; Fiscal Year: 2008
  6. TGF-BETA AND IMMUNOSUPPRESSION IN ORGAN TRANSPLANTATION
    Ashwani Khanna; Fiscal Year: 2002
  7. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009
  8. Cyclin D1 and mammary carcinoma
    J Diehl; Fiscal Year: 2009
  9. 7th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2008
  10. CELL CYCLE CONTROL IN GLOMERULAR DISEASE
    Stuart Shankland; Fiscal Year: 2007

Detail Information

Publications148 found, 100 shown here

  1. pmc p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells
    J Brugarolas
    Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Cell Biol 141:503-14. 1998
    ..extrinsic factors, specific loss of function mutations were generated in two negative regulators of G1 progression, p21 and pRB...
  2. ncbi Heterozygosity of p21WAF1/CIP1 enhances tumor cell proliferation and cyclin D1-associated kinase activity in a murine mammary cancer model
    J M Jones
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell Growth Differ 10:213-22. 1999
    The p21(WAF1/cIP1) cyclin-dependent kinase (cdk) inhibitor is a regulator of the G(1)-S cell cycle checkpoint. Despite the importance of p21 in cell cycle inhibition, its role as a tumor suppressor is uncertain...
  3. ncbi The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development
    D Balomenos
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Cantoblanco, E 28049 Madrid, Spain
    Nat Med 6:171-6. 2000
    Here we show that the cell-cycle regulator p21 is involved in immune system function...
  4. ncbi p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export
    Jodi R Alt
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 277:8517-23. 2002
    There is increasing evidence that p21(Cip1) and p27(Kip1) are requisite positive regulators of cyclin D1.CDK4 assembly and nuclear accumulation...
  5. ncbi Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis
    Aksam J Merched
    Department of Molecular, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Circulation 110:3830-41. 2004
    ..A major target of p53 is p21, the cyclin-dependent kinase inhibitor that regulates entry into the cell cycle of different types of cells, ..
  6. ncbi Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    C Deng
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 82:675-84. 1995
    b>p21CIP1/WAF1 is a CDK inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been suggested to derive anti-oncogenic properties from this relationship...
  7. ncbi Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    T Cheng
    Experimental Hematology, AIDS Research Center, Massachusetts General Hospital Cancer Center, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Science 287:1804-8. 2000
    ..assessed using mice engineered to be deficient in the G1 checkpoint regulator, cyclin-dependent kinase inhibitor, p21cip1/waf1 (p21)...
  8. ncbi p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells
    S B Parker
    Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
    Science 267:1024-7. 1995
    Terminal differentiation is coupled to withdrawal from the cell cycle. The cyclin-dependent kinase inhibitor (CKI) p21Cip1 is transcriptionally regulated by p53 and can induce growth arrest...
  9. pmc p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus
    Robert N Pechnick
    Department of Medicine, Division of Endocrinology, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 105:1358-63. 2008
    ..Cyclin-dependent kinases (CDKs) have a primary role in controlling cell division and cellular proliferation. p21(Cip1) (p21) is a CDK inhibitor that restrains cell cycle progression...
  10. pmc p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step
    P Zhang
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 13:213-24. 1999
    ..Here we show that two Cdk inhibitors, p21(CIP1) and p57(KIP2), redundantly control differentiation of skeletal muscle and alveoli in the lungs...
  11. ncbi Transcriptional regulation of the p21((WAF1/CIP1)) gene
    A L Gartel
    Department of Molecular Genetics, University of Illinois at Chicago, 900 South Ashland Avenue, Room 2072, Chicago, Illinois, 60607, USA
    Exp Cell Res 246:280-9. 1999
  12. pmc The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
    M Cheng
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    EMBO J 18:1571-83. 1999
    ..that normal up-regulation of cyclin D- CDK4 in mitogen-stimulated fibroblasts depends redundantly upon p21(Cip1) and p27(Kip1)...
  13. ncbi Cell-cycle inhibitors p27Kip1 and p21Cip1 regulate murine Sertoli cell proliferation
    Denise R Holsberger
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    Biol Reprod 72:1429-36. 2005
    ..recent results have shown that thyroid hormone upregulates cyclin-dependent kinase inhibitors (CDKIs) p27Kip1 and p21Cip1 (also known as CDKN1B and CDKN1A, respectively) in neonatal Sertoli cells...
  14. pmc Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development
    P Zhang
    Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York 10461 USA
    Genes Dev 12:3162-7. 1998
    ..These studies demonstrate that p27(KIP1) and p57(KIP2) are critical terminal effectors of signal transduction pathways that control cell differentiation...
  15. pmc Miz1 is required for early embryonic development during gastrulation
    Sovana Adhikary
    Institute for Molecular Biology and Tumor Research Institute for Cytobiology and Cytopathology, University of Marburg, 35033 Marburg, Germany
    Mol Cell Biol 23:7648-57. 2003
    ..Expression of p21Cip1, a target gene of Miz1 is unaltered; in contrast, expression of p57Kip2, another target gene of Miz1 is absent in ..
  16. pmc The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
    Johanna Mantela
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 132:2377-88. 2005
    ..In addition to Rb, the cyclin dependent kinase inhibitor (CKI) p21 is expressed in developing hair cells, suggesting that p21 is an upstream effector of pRb activity...
  17. doi Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors
    Heidi Laine
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 337:134-46. 2010
    ..the spatiotemporal pattern of unscheduled cell cycle re-entry of cochlear hair cells from the p19(Ink4d)/p21(Cip1) compound mutant mice...
  18. ncbi Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome
    P Zhang
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 387:151-8. 1997
    ....
  19. ncbi Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration
    H Wu
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, 27599 USA
    Genes Dev 10:245-60. 1996
    The CDK inhibitor p21 (WAF-1/CIP-1/SDI-1) has been implicated in DNA damage-induced p53-mediated G1 arrest, as well as in physiological processes, such as cell differentiation and senescence, that do not involve p53 function...
  20. ncbi Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal
    W C Yang
    Albert Einstein Cancer Center, Bronx, New York 10467, USA
    Cancer Res 61:565-9. 2001
    Elimination of both alleles of the gene that encodes the cyclin kinase inhibitor p21(WAF1/cip1) increases the frequency and size of intestinal tumors in Apc1638+/- mice that inherit a mutant allele of the Apc gene, and intermediate ..
  21. ncbi Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor
    Sharon Prince
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, United Kingdom
    Cancer Res 64:1669-74. 2004
    ..The p21(WAF1) cyclin-dependent kinase inhibitor plays a key role in senescence and in cell cycle arrest after DNA damage...
  22. ncbi Cell cycle inhibitors p21 and p16 are required for the regulation of Schwann cell proliferation
    Suzana Atanasoski
    Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Glia 53:147-57. 2006
    ..In the present study, we have investigated the function of the cell cycle inhibitors p21 and p16 as potential regulators of Schwann cell proliferation, using p21- or p16-deficient mice...
  23. pmc P21cip-overexpression in the mouse beta cells leads to the improved recovery from streptozotocin-induced diabetes
    Jie Yang
    The MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking University, Beijing, China
    PLoS ONE 4:e8344. 2009
    ..the pancreatic beta cell regeneration, which could specifically inhibit beta cell proliferation by overexpressing p21(cip) in beta cells via regulation of the Tet-on system...
  24. ncbi p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage
    K F Macleod
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 9:935-44. 1995
    Expression of p21 has been shown to be up-regulated by the p53 tumor suppressor gene in vitro in response to DNA-damaging agents...
  25. ncbi Role of cyclin kinase inhibitor p21 in systemic autoimmunity
    M L Santiago-Raber
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 167:4067-74. 2001
    The cyclin kinase inhibitor protein p21 affects multiple processes relevant to the immune system, including cell cycle progression, replicative senescence, hemopoietic stem cell quiescence, and apoptosis...
  26. ncbi The cell cycle inhibitory protein p21cip is not essential for maintaining beta-cell cycle arrest or beta-cell function in vivo
    Irene Cozar-Castellano
    Division of Endocrinology, BST E 1140, University of Pittsburgh School of Medicine, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Diabetes 55:3271-8. 2006
    p21(cip1), a regulatory molecule upstream of the G(1/0) checkpoint, is increased in beta-cells in response to mitogenic stimulation...
  27. ncbi Radiation-induced cell cycle arrest compromised by p21 deficiency
    J Brugarolas
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 377:552-7. 1995
    The protein p21 is a dual inhibitor of cyclin-dependent kinases and proliferating-cell nuclear antigen (PCNA), both of which are required for passage through the cell cycle. The p21 gene is under the transcriptional control of p53 (ref...
  28. ncbi p21 is a universal inhibitor of cyclin kinases
    Y Xiong
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724
    Nature 366:701-4. 1993
    ..in multiple quaternary complexes, each containing a CDK, cyclin, proliferating cell nuclear antigen and the p21 protein...
  29. ncbi Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation
    P Casaccia-Bonnefil
    Molecular Neurobiology, Skirball Institute for Biomolecular Medicine at NYU Medical Center, New York, NY 10016, USA nyu edu
    Development 126:4027-37. 1999
    ....
  30. ncbi Heme oxygenase-1 protects against vascular constriction and proliferation
    H J Duckers
    Vascular Biology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Nat Med 7:693-8. 2001
    ..The unexpected effects of HO-1 on vascular smooth muscle cell growth were mediated by cell-cycle arrest involving p21Cip1. HO-1 reduced the proliferative response to vascular injury in vivo; expression of HO-1 in pig arteries inhibited ..
  31. ncbi The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress
    M A O'Reilly
    Departments of Pediatrics Neonatology, School of Medicine and Dentistry, The University of Rochester, Rochester, New York, USA
    Am J Respir Cell Mol Biol 24:703-10. 2001
    ..induces the tumor suppressor p53 and its downstream target, the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1) (p21), their role in pulmonary injury remains unknown...
  32. ncbi Tumor susceptibility of p21(Waf1/Cip1)-deficient mice
    J Martin-Caballero
    Department of Immunology and Oncology, National Center of Biotechnology Spanish Council for Scientific Research, Campus de Cantoblanco, Madrid E 28049, Spain
    Cancer Res 61:6234-8. 2001
    The cell cycle regulator p21 mediates the ability of the tumor suppressor p53 to arrest cellular proliferation...
  33. ncbi Mutated p21/WAF/CIP transgene overexpression reduces smooth muscle cell proliferation, macrophage deposition, oxidation-sensitive mechanisms, and restenosis in hypercholesterolemic apolipoprotein E knockout mice
    G Condorelli
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    FASEB J 15:2162-70. 2001
    ..Ad-mutated(m)-p21WAF/CIP1 transgene overexpression induces a significant reduction of restenosis in hypercholesterolemic apolipoprotein ..
  34. ncbi Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome
    Jesus M Salvador
    Gene Response Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Immunity 16:499-508. 2002
    This study addresses the biological function of the p53-effector genes Gadd45a and p21 in the immune system...
  35. ncbi p21 is essential for normal myogenic progenitor cell function in regenerating skeletal muscle
    T J Hawke
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8573, USA
    Am J Physiol Cell Physiol 285:C1019-27. 2003
    ..Although mice lacking the cyclin-dependent kinase inhibitor p21 (p21-/-), develop normally, we report here that p21-/- MPCs display increased cell number and enhanced cell cycle ..
  36. ncbi HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice
    Youliang Wang
    Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, China
    Hepatology 39:318-24. 2004
    ..HBsAg and HBx genes were integrated into the mouse p21 locus...
  37. ncbi Cellular senescence induced by p53-ras cooperation is independent of p21waf1 in murine embryo fibroblasts
    Maria E Castro
    Experimental Therapeutics Program, Centro Nacional de Investigaciones Oncologicas CNIO, Melchor Fernandez Almagro, 3, 28029, Madrid Spain
    J Cell Biochem 92:514-24. 2004
    ..Introduction of a conditional murine p53 allele (p53val135) into double p53/p21-null mouse embryonic fibroblasts showed that p21waf1 was not required for this effect, since p53-/-;p21-/- double-..
  38. ncbi p21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells
    Masahiro Nakajima
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Suwarashi, Sagamiko, Kanagawa 199 0195, Japan
    Biochem Biophys Res Commun 320:1069-75. 2004
    ..We have previously clarified that the induction of the cyclin-dependent kinase inhibitor, p21(Cip-1/SDI-1/WAF-1), is essential for chondrogenic differentiation of ATDC5 cells...
  39. ncbi Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 131:5041-52. 2004
    ..Despite evidence that TBX2 negatively regulates the cell cycle control genes Cdkn2a, Cdkn2b and Cdkn1a in cultured cells, there is no evidence that loss of Tbx2 function during mouse development results in increased ..
  40. ncbi N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1)
    Xueyan Chen
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98029, USA
    Mol Cell 16:839-47. 2004
    Expression of the CDK inhibitor p21(Cip1) is tightly regulated by signals that control cell division...
  41. ncbi UV Induces p21 rapid turnover independently of ubiquitin and Skp2
    Hunjoo Lee
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 281:26876-83. 2006
    ..not high doses, of UV trigger the Skp2-mediated proteasomal degradation of the cyclin-dependent kinase inhibitor p21 in mammalian cells...
  42. pmc A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis
    James M Woods
    Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA
    Arthritis Res Ther 8:R113. 2006
    ..We demonstrated previously that expression of the cell cycle inhibitor p21 is significantly reduced in RA synovial lining, particularly in the FLS...
  43. pmc Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development
    Guetchyn Millien
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    BMC Dev Biol 6:35. 2006
    ..Since little is known about the molecular pathways driving alveolar sacculation, we used expression microarrays to identify genes altered in the abnormal lungs and, by inference, may play roles in normal lung morphogenesis...
  44. pmc Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene
    Thordur Oskarsson
    Genetics and Stem Cell Laboratory, Swiss Institute for Experimental Cancer Research ISREC Ch des Boveresses 155, Epalinges, Switzerland
    Genes Dev 20:2024-9. 2006
    ..This is mechanistically linked to p21(Cip1), which is induced in tumors by the activated Ras-ERK pathway but repressed by c-Myc...
  45. ncbi Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
    Aaheli Roy Choudhury
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Nat Genet 39:99-105. 2007
    ..cells by activation of DNA damage pathways, including upregulation of the cell cycle inhibitor p21 (encoded by Cdkn1a, also known as Cip1 and Waf1)) (refs. 1-5)...
  46. ncbi p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis
    Heidi Laine
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 27:1434-44. 2007
    ..Here we show the synergistic action of another CKI, p21(Cip1), on cell cycle reactivation...
  47. doi shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development
    Christopher A Fasano
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Cell Stem Cell 1:87-99. 2007
    ..and adult NSC proliferation and self-renewal that, unexpectedly, are mediated by a different cell-cycle inhibitor, p21. Gene array analyses revealed developmental differences in Bmi-1-controlled expression of genes in the p21-Rb cell ..
  48. pmc p21Cip1 modulates arterial wound repair through the stromal cell-derived factor-1/CXCR4 axis in mice
    Michelle Olive
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland 20817, USA
    J Clin Invest 118:2050-61. 2008
    Cyclin-dependent kinase inhibitors, including p21Cip1, are implicated in cell turnover and are active players in cardiovascular wound repair...
  49. pmc Feedback between p21 and reactive oxygen production is necessary for cell senescence
    Joao F Passos
    Ageing Research Laboratories, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Mol Syst Biol 6:347. 2010
    ..The essential feature of the loop is that long-term activation of the checkpoint gene CDKN1A (p21) induces mitochondrial dysfunction and production of reactive oxygen species (ROS) through serial signalling ..
  50. pmc Lack of p21 expression links cell cycle control and appendage regeneration in mice
    Khamilia Bedelbaeva
    Cellular and Molecular Oncogenesis and Gene Expression, The Wistar Institute, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:5845-50. 2010
    ..mapped and reliable quantitative indicator of regeneration in the MRL mouse, we show that the unrelated Cdkn1a(tmi/Tyj)/J p21(-/-) mouse (unlike the B6129SF2/J WT control) closes ear holes similar to MRL mice, providing a ..
  51. pmc 53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response
    Paula Martinez
    Telomeres and Telomerase Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, E 28029 Madrid, Spain
    J Cell Biol 197:283-300. 2012
    ..In intact mice, combined 53BP1/TRF1 deficiency in stratified epithelia resulted in earlier onset of DNA damage and increased CHK1 phosphorylation during embryonic development, leading to aggravation of skin phenotypes...
  52. pmc Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
    Diana Jurk
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Aging Cell 11:996-1004. 2012
    ..It was fully rescued by loss of p21(CDKN1A) function in late-generation TERC-/-CDKN1A-/- mice, indicating p21 as the necessary signal transducer between DNA ..
  53. ncbi p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene
    S Matsuoka
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 9:650-62. 1995
    ..We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1...
  54. ncbi WAF1, a potential mediator of p53 tumor suppression
    W S El-Deiry
    Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231
    Cell 75:817-25. 1993
    ..Using a subtractive hybridization approach, we identified a gene, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line...
  55. pmc Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation
    S X Skapek
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 16:7043-53. 1996
    ....
  56. ncbi The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot
    J Jernvall
    Institute of Biotechnology, University of Helsinki, Finland
    Development 125:161-9. 1998
    ..in the enamel knot in mouse molar teeth is linked with the expression of the cyclin-dependent kinase inhibitor p21. We show that p21 expression is induced by bone morphogenetic protein 4 (BMP-4) in isolated dental epithelia...
  57. ncbi Cip/Kip cyclin-dependent kinase inhibitors: brakes of the cell cycle engine during development
    K Nakayama
    Department of Molecular and Cellular Biology, Kyushu University, Fukuoka, Japan
    Bioessays 20:1020-9. 1998
    ..In this review, the biological roles of Cip/Kip CKIs in development and tumor suppression are discussed...
  58. pmc p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential
    G I Topley
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 96:9089-94. 1999
    p21(WAF1/Cip1) is one of the best characterized downstream targets of p53, and the growth suppressing function of this cyclin-dependent kinase inhibitor is well established...
  59. pmc Transcription factor Sp3 is essential for post-natal survival and late tooth development
    P Bouwman
    Institut fur Molekularbiologie und Tumorforschung, Emil Mannkopff Strasse 2
    EMBO J 19:655-61. 2000
    ..Comparison of the Sp1 and Sp3 knockout phenotype shows that Sp1 and Sp3 have distinct functions in vivo, but also suggests a degree of functional redundancy...
  60. ncbi Cell-cycle inhibitors: three families united by a common cause
    A Vidal
    Laboratory of Cell Cycle Regulation, Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Gene 247:1-15. 2000
    ..We will discuss the interrelationships between Cip/Kip inhibitors and the components of the pRb pathway, and how their activities ultimately regulate cell proliferation...
  61. ncbi Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2
    T Aikawa
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 276:29347-52. 2001
    ..FGF2 increased p21 expression in RCS cells, which assembled with the cyclin E-Cdk2 complexes, although the expression of neither ..
  62. ncbi UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair
    Mourad Bendjennat
    Institut de Biologie Structurale J P Ebel, 41 rue Jules Horowitz, F38027 Grenoble, France
    Cell 114:599-610. 2003
    p53-mediated increase in cyclin-dependent kinase inhibitor p21(WAF1) protein is thought to be the major mediator of cell cycle arrest after DNA damage...
  63. ncbi Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    Joan Seoane
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 1300 York Avenue, New York, NY 1002, USA
    Cell 117:211-23. 2004
    ..Smad proteins activated by TGF-beta form a complex with FoxO proteins to turn on the growth inhibitory gene p21Cip1. This process is negatively controlled by the PI3K pathway, a known inhibitor of FoxO localization in the nucleus,..
  64. ncbi Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    Marcos Malumbres
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, E 28029 Madrid, Spain
    Cell 118:493-504. 2004
    ..These results indicate that D-type cyclin-dependent kinases are not essential for cell cycle entry and suggest the existence of alternative mechanisms to initiate cell proliferation upon mitogenic stimulation...
  65. pmc p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity
    Tod E Kippin
    Neurobiology Research Group, Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genes Dev 19:756-67. 2005
    Adult stem cells in various tissues are relatively quiescent. The cell cycle inhibitor p21cip1/waf1 (p21) has been shown to be important for maintaining hematopoietic stem cell quiescence and self-renewal...
  66. ncbi Evaluation of beta-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21cip
    Irene Cozar-Castellano
    Division of Endocrinology, BST E 1140, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Diabetes 55:70-7. 2006
    ..checkpoint regulators (E2Fs; pRb; p107; p130; cyclins D(1),(2),(3), A, and E; cdk-2; cdk-4; p15; p16; p18; p19; p21; p27; MDM2; p53; c-Myc; and Egr-1) are present in the murine islet...
  67. ncbi p53 and p21 regulate error-prone DNA repair to yield a lower mutation load
    Sharon Avkin
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell 22:407-13. 2006
    ..We found that in mammalian cells TLS is controlled by the tumor suppressor p53, and by the cell cycle inhibitor p21 via its PCNA-interacting domain, to maintain a low mutagenic load at the price of reduced repair efficiency...
  68. ncbi p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors
    Senta Georgia
    Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Dev Biol 298:22-31. 2006
    ....
  69. ncbi Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway
    Takeshige Kunieda
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Circulation 114:953-60. 2006
    ..We have previously demonstrated that vascular cell senescence contributes to the pathogenesis of atherosclerosis; however, the effects of Ang II on vascular cell senescence have not been examined...
  70. pmc Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation
    Linda Panic
    Department of Molecular Medicine and Biotechnology, School of Medicine, University of Rijeka, Brace Branchetta 20, 51000, Rijeka, Croatia
    Mol Cell Biol 26:8880-91. 2006
    ..Thus, a p53-dependent checkpoint is activated during gastrulation in response to ribosome insufficiency to prevent improper execution of the developmental program...
  71. pmc Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex
    Douglas I Lin
    The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell 24:355-66. 2006
    ..We conclude that SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1...
  72. pmc APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase
    Virginia Amador
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue MSB 599, New York, NY 10016, USA
    Mol Cell 27:462-73. 2007
    During the G1/S transition, p21 proteolysis is mediated by Skp2; however, p21 reaccumulates in G2 and is degraded again in prometaphase. How p21 degradation is controlled in mitosis remains unexplored...
  73. pmc Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation
    Ssang Taek Lim
    Department of Reproductive Medicine, Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC0803, La Jolla, CA 92093, USA
    Mol Cell 29:9-22. 2008
    ..Here we show that, during mouse development, FAK inactivation results in p53- and p21-dependent mesodermal cell growth arrest...
  74. pmc Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice
    Hongwei Yao
    Lung Biology and Disease Program, Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 39:7-18. 2008
    The cyclin-dependent kinase inhibitor p21(CIP1/WAF1/SDI1) (p21) is an important inhibitory checkpoint regulator of cell cycle progression in response to oxidative and genotoxic stresses...
  75. doi Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia
    Anna Kirjavainen
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 322:33-45. 2008
    ..The data point to the tight regulation of phenotypic characteristics of hair cells and supporting cells...
  76. pmc Transmission distortion by loss of p21 or p27 cyclin-dependent kinase inhibitors following competitive spermatogonial transplantation
    Mito Kanatsu-Shinohara
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:6210-5. 2010
    ..Here we developed a novel transplantation assay for SSCs and demonstrate that p21 and p27 cyclin-dependent kinase inhibitors play critical roles in SSC self-renewal and differentiation...
  77. pmc Replication of minute virus of mice in murine cells is facilitated by virally induced depletion of p21
    Richard O Adeyemi
    Department of Molecular Microbiology and Immunology, University of Missouri Columbia, School of Medicine, Columbia, Missouri, USA
    J Virol 86:8328-32. 2012
    The DNA damage response to infection with minute virus of mice (MVM) leads to activated p53; however, p21 levels are reduced via a proteasome-mediated mechanism...
  78. pmc p21 promotes error-free replication-coupled DNA double-strand break repair
    Maurizio Mauro
    Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI 02881, USA
    Nucleic Acids Res 40:8348-60. 2012
    b>p21 is a well-established regulator of cell cycle progression. The role of p21 in DNA repair, however, remains poorly characterized...
  79. doi Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis via up-regulation of cytoplasmic p21 expression
    Masahiko Yano
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University, Niigata, Japan
    Liver Int 33:1218-29. 2013
    ..Cyclin-dependent kinase inhibitor p21 (Cip1/WAF1), known as a tumour-suppressor gene, has been reported to have paradoxical function, that is, acting as an oncogene,..
  80. ncbi Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues
    W S El-Deiry
    Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 55:2910-9. 1995
    The p53-regulated gene product p21WAF1/CIP1 is the prototype of a family of small proteins that negatively regulate the cell cycle...
  81. pmc Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity
    Hiroyuki Tanaka
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Cell Biol 158:321-9. 2002
    p21(Cip1/WAF1) has cell cycle inhibitory activity by binding to and inhibiting both cyclin/Cdk kinases and proliferating cell nuclear antigen...
  82. ncbi p21Cip1 nullizygosity increases tumor metastasis in irradiated mice
    Rosalind J Jackson
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, and Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Cancer Res 63:3021-5. 2003
    p21(Cip1) is a cyclin-dependent kinase inhibitor whose abundance increases in cells exposed to radiation or other DNA-damaging agents. Such increases activate a G1 checkpoint, which allows time for DNA repair before S phase entry...
  83. ncbi A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning
    Ronald van Os
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, Groningen, The Netherlands
    Stem Cells 25:836-43. 2007
    Several studies have suggested that the cyclin-dependent kinase (CDK) inhibitor p21 plays a crucial role in regulating hematopoietic stem and progenitor pool size...
  84. ncbi Pivotal role of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in apoptosis and autophagy
    Keishi Fujiwara
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Biol Chem 283:388-97. 2008
    ..The purpose of this study was to show whether the presence of the cyclin-dependent kinase (CDK) inhibitor p21(WAF1/CIP1), a modulator of apoptosis, determines which type of PCD the cell undergoes...
  85. ncbi Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts
    Janice L Walker
    Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    J Biol Chem 281:38127-32. 2006
    p21(cip1) inhibits S phase entry by binding to cyclin-cdk2 (cyclin-dependent kinase-2) complexes...
  86. pmc p53 prevents entry into mitosis with uncapped telomeres
    Maria Thanasoula
    Telomere and Genome Stability Group, The CR UK MRC Gray Institute for Radiation Oncology and Biology, Old Road Campus, Oxford OX37DQ, UK
    Curr Biol 20:521-6. 2010
    ..Here, we report that telomere capping is monitored at the G2/M transition by the p53/p21 damage response pathway...
  87. ncbi IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts
    Harris Perlman
    Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Immunol 170:838-45. 2003
    ..Here, we demonstrate a 50 +/- 10% decrease in the expression of p21, a cell cycle inhibitor, in the synovial fibroblast population from RA compared with osteoarthritis (OA) synovial ..
  88. pmc p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex
    Laurent Nguyen
    Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Genes Dev 20:1511-24. 2006
    ..Thus, p27(Kip1) plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways contributing to neurogenesis...
  89. pmc Adenovirus E1A-regulated transcription factor p120E4F inhibits cell growth and induces the stabilization of the cdk inhibitor p21WAF1
    E R Fernandes
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 18:459-67. 1998
    ..These data suggest an important role for p120E4F in normal cell division and demonstrate that p21WAF1 can be regulated by protein turnover...
  90. ncbi Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3
    W M ElShamy
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Neuron 21:1003-15. 1998
    ..Our results provide evidence for novel activity of neurotrophins in cell cycle control and point toward an N-myc sensitization to cell death in the nervous system that is under the control of NT-3...
  91. ncbi p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo
    W Yang
    Department of Oncology, Albert Einstein Cancer Center, Bronx, New York 10467, USA
    Cancer Res 61:6297-302. 2001
    ..Among these changes was induction of the cyclin-dependent kinase inhibitor, p21(WAF1/cip1)...
  92. ncbi Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus
    Ruth H Florese
    Department of Microbiology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Virus Res 90:119-31. 2002
    ..The core protein, the nonstructural protein 4A (NS4A) and NS4B, but not NS3, NS5A or NS5B, inhibited p21/Waf1 expression post-transcriptionally...
  93. pmc T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21(CIP1/WAF1) expression
    Zhi Yong Huang
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 23:566-78. 2003
    ..T-cadherin-expressing C6 cell lines exhibited increased p21(CIP1/WAF1), but not p27(Kip1), expression...
  94. ncbi Mouse development and cell proliferation in the absence of D-cyclins
    Katarzyna Kozar
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 118:477-91. 2004
    ..Lastly, we found that cells lacking D-cyclins display reduced susceptibility to the oncogenic transformation. Our results reveal the presence of alternative mechanisms that allow cell cycle progression in a cyclin D-independent fashion...
  95. ncbi p21Cip1 and p27Kip1 act in synergy to alter the sensitivity of naive T cells to TGF-beta-mediated G1 arrest through modulation of IL-2 responsiveness
    Lawrence A Wolfraim
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:3093-102. 2004
    Induction of G(1) arrest by TGF-beta correlates with the regulation of p21(Cip1) and p27(Kip1), members of the Cip/Kip family of cyclin-dependent kinase inhibitors (cki)...
  96. ncbi Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation
    Bin Wang
    Department of Molecular Genetics and The Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Development 131:4477-87. 2004
    ....
  97. ncbi p21(Cip1/WAF1/Sdi1) does not affect expression of base excision DNA repair enzymes during chronic oxidative stress
    MICHAEL A O'REILLY
    Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Antioxid Redox Signal 7:719-25. 2005
    ..damages DNA and inhibits cell proliferation in G(1) through induction of the cyclin-dependent kinase inhibitor p21. Cells that fail to express p21 growth-arrest in S phase...
  98. ncbi The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice
    Andreas Petri
    Department of Molecular Genetics, Novo Nordisk A S, DK 2880 Bagsvaerd, Denmark
    J Mol Endocrinol 37:301-16. 2006
    ..These data suggest that Irx1 and Irx2 serve an evolutionary conserved role in the regulation of alpha-cell-specific gene expression...
  99. pmc The anaphase-promoting complex coordinates initiation of lens differentiation
    George Wu
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15312, USA
    Mol Biol Cell 18:1018-29. 2007
    ..Cyclin-dependent kinase inhibitors (CKIs), such as p15 and p21, have been suggested to be critical components that inhibit G1 progression and therefore, their activation is ..
  100. ncbi p21CIP1/WAF1 controls proliferation of activated/memory T cells and affects homeostasis and memory T cell responses
    Cristina F Arias
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus de Cantoblanco, Madrid, Spain
    J Immunol 178:2296-306. 2007
    Development of autoantibodies and lupus-like autoimmunity by 129/Sv x C57BL/6 p21(-/-) mice has established that cell cycle deregulation is one the defective pathways leading to break of tolerance...
  101. ncbi Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract
    Yi Hui Chen
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center and Hospital, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Dev Biol 308:421-37. 2007
    ....

Research Grants18

  1. Role of fractalkine signaling in rheumatoid arthritis
    James Woods; Fiscal Year: 2004
    ..These experiments should provide extensive new insights about the mechanism of fkn signaling through CX3CR1 and its relationship to cellular function. ..
  2. TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURY
    MICHAEL O REILLY; Fiscal Year: 2002
    ..These studies are significant because understanding how ROS injure and kill pulmonary epithelial cells is critically important for improving clinical therapies that rely on supplemental oxygen. ..
  3. P21 transcriptional inhibitors as proapoptotic compounds
    Andrei Gartel; Fiscal Year: 2003
    ..The cyclin-dependent kinase inhibitor p21 (Wafl/Cipl) is induced at the transcriptional level both by signaling pathways that participate in the development ..
  4. COORDINATE REGULATION OF APOPTOSIS AND CELL CYCLE IN RA
    Harris Perlman; Fiscal Year: 2004
    ..This approach could lead to the development of a new therapeutic strategy for gene therapy in patients with rheumatoid arthritis. ..
  5. The role BH3 and multi BH domain genes in regulating monocyte survival and functi
    Harris Perlman; Fiscal Year: 2008
    ..Further our goal is to characterize mice lacking Bim or it signaling partners only in monocytes and macrophages. [unreadable] [unreadable] [unreadable]..
  6. TGF-BETA AND IMMUNOSUPPRESSION IN ORGAN TRANSPLANTATION
    Ashwani Khanna; Fiscal Year: 2002
    ..of immunosuppressive drugs, and TGF-B has been reported to induce the expression of one cell cycle inhibitor, p21. The investigators' that this phenomenon may be TGF-B- independent...
  7. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009
    ..Based on data obtained in this project, we are planning to start developing a strategy to correct liver proliferation in elderly. ..
  8. Cyclin D1 and mammary carcinoma
    J Diehl; Fiscal Year: 2009
    ..The work proposed herein will establish the relationship between cyclin D1 nuclear retention and the function of cyclin D1 as an oncogenic protein in mammary carcinoma. ..
  9. 7th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2008
    ..In summary, the only hope for our patients is by focused and concerted efforts such as the 7th International Podocyte Conference which will ultimately enhance their overall care. [unreadable] [unreadable] [unreadable]..
  10. CELL CYCLE CONTROL IN GLOMERULAR DISEASE
    Stuart Shankland; Fiscal Year: 2007
    ..We will test the hypothesis that p53 and the CDK-inhibitor p21 mediate the anti-proliferative effects of DNA damage on podocytes, utilizing cultured podocytes derived from p53 ..
  11. 6th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2006
    ..Moreover, this is an exciting era in podocytes biology given the large body of literature that has been published in the past 2-5 years. [unreadable] [unreadable] [unreadable]..
  12. The Role of Cyclin A in Cardiac Development
    HINA CHAUDHRY; Fiscal Year: 2006
    ..abstract_text> ..
  13. MECHANISMS OF PODOCYTE INJURY
    Stuart Shankland; Fiscal Year: 2005
    ..We will test the hypothesis that stretch increases the levels of CDK-inhibitors (p21, p27, p57), thereby inhibiting proliferation, and inducing hypertrophy. Specific null podo be used for study...
  14. 5TH INTERNATIONAL PODOCYTE CONFERENCE
    Stuart Shankland; Fiscal Year: 2004
    ..3. To facilitate cross-talk between clinicians and scientists with the ultimate goal of improving prognosis, treatment and care of patients with glomerular disease. ..
  15. FUNCTIONAL STUDIES OF IMMUNOGLOBULIN KAPPA ENHANCERS
    Yang Xu; Fiscal Year: 2004
    ..We will again employ genetic approaches to further explore the functions of MiEkappa in somatic hypermutations of Igkappa in a physiological context. ..
  16. Mechanisms of pathogenesis in ataxia-telanglectasia
    Yang Xu; Fiscal Year: 2006
    ..In addition, I propose to investigate the functional interactions between NBS1 and H2AX, the two mediators of ATM functions. ..
  17. Sex Differences and Incubation of Cocaine Craving
    TOD KIPPIN; Fiscal Year: 2005
    ..These initial experiments will form the bases of subsequent studies examining the organizational and activational effects of gonadal hormones and the neuroendocrine bases of sex differences in time-dependent neuroadaptations. ..
  18. Regulation of Nanog in DNA damage response, development and tumorigenesis
    Yang Xu; Fiscal Year: 2010
    ..In addition, these studies will shed light on mechanism that maintains genetic stability in human ESCs, which have a great potential for future human cell/tissue replacement therapy. ..