Cdk2

Summary

Gene Symbol: Cdk2
Description: cyclin-dependent kinase 2
Alias: A630093N05Rik, cyclin-dependent kinase 2, cell division protein kinase 2
Species: mouse

Top Publications

  1. ncbi Temporal patterns of gene expression of G1-S cyclins and cdks during the first and second mitotic cell cycles in mouse embryos
    G D Moore
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia 19104 6018, USA
    Mol Reprod Dev 45:264-75. 1996
  2. pmc The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis
    A Hakem
    The Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada M5G 2C1
    J Exp Med 189:957-68. 1999
  3. pmc A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene
    X Ye
    Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:1682-6. 2001
  4. ncbi Glutamate regulates retinal progenitors cells proliferation during development
    Rodrigo A P Martins
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Eur J Neurosci 24:969-80. 2006
  5. ncbi CDK2 is dispensable for adult hippocampal neurogenesis
    Renaud Vandenbosch
    Center for Cellular and Molecular Neuroscience, University of Liege, Liege, Belgium
    Cell Cycle 6:3065-9. 2007
  6. pmc Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
    M Kasim Diril
    Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research ASTAR, Republic of Singapore 138673
    Proc Natl Acad Sci U S A 109:3826-31. 2012
  7. ncbi Insulin-like growth factor-1 receptor and its ligand regulate the reentry of adult ventricular myocytes into the cell cycle
    K Reiss
    Department of Medicine and Division of Cardiology, New York Medical College, Valhalla, New York 10595, USA
    Exp Cell Res 235:198-209. 1997
  8. ncbi Cyclin A2-CDK2 regulates embryonic gene activation in 1-cell mouse embryos
    Kentaro T Hara
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Shinryoiki Seimei Building 302, 5 1 5, Kashiwa no ha, Kashiwa shi, Chiba 277 8562, Japan
    Dev Biol 286:102-13. 2005
  9. ncbi Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes
    Laura A Jansen
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 46:1871-80. 2005
  10. ncbi The differential catalytic activity of alternatively spliced cdk2 alpha and cdk2 beta in the G1/S transition and early S phase
    T K Kwon
    Laboratory of Immunology, National Institute on Aging, NIH, Baltimore, Maryland 21224 2780, USA
    Exp Cell Res 238:128-35. 1998

Research Grants

  1. Transcriptional regulation of apoptosis
    JAMES MANFREDI; Fiscal Year: 2007
  2. FUNCTION OF A DUAL SPECIFICITY TRANSCRIPTION FACTOR
    Peter Hurlin; Fiscal Year: 2003
  3. The Role of Cyclin A in Cardiac Development
    HINA CHAUDHRY; Fiscal Year: 2006
  4. The identification and characterization of the mammalian mutation mei4
    Jeremy Ward; Fiscal Year: 2006
  5. Myc Antagonism and Tumor Suppression by Mnt
    Peter Hurlin; Fiscal Year: 2008
  6. Genomic instability induced by the HPV-16 E7 oncoprotein
    Stefan Duensing; Fiscal Year: 2009
  7. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications134 found, 100 shown here

  1. ncbi Temporal patterns of gene expression of G1-S cyclins and cdks during the first and second mitotic cell cycles in mouse embryos
    G D Moore
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia 19104 6018, USA
    Mol Reprod Dev 45:264-75. 1996
    ..The levels of PCR products for cyclin D2, p27, and two forms of cdk2 were similar in meiotically incompetent and competent oocytes but decreased during oocyte maturation...
  2. pmc The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis
    A Hakem
    The Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada M5G 2C1
    J Exp Med 189:957-68. 1999
    ..Here we show that in noncycling developing thymocytes, the cyclin- dependent kinase Cdk2 is activated in response to all specific and nonspecific apoptotic stimuli tested, including peptide-specific ..
  3. pmc A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene
    X Ye
    Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:1682-6. 2001
    ..In contrast, little is known about CDK3, a homolog of CDK2 and cell division cycle kinase 2 (CDC2)...
  4. ncbi Glutamate regulates retinal progenitors cells proliferation during development
    Rodrigo A P Martins
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Eur J Neurosci 24:969-80. 2006
    ..Instead, the activity of the Cdk2 kinase is reduced in the presence of glutamate...
  5. ncbi CDK2 is dispensable for adult hippocampal neurogenesis
    Renaud Vandenbosch
    Center for Cellular and Molecular Neuroscience, University of Liege, Liege, Belgium
    Cell Cycle 6:3065-9. 2007
    ..Among cell cycle regulators, cyclin-dependent kinase 2 (Cdk2) is considered as a major regulator of S-phase entry...
  6. pmc Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
    M Kasim Diril
    Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research ASTAR, Republic of Singapore 138673
    Proc Natl Acad Sci U S A 109:3826-31. 2012
    ..Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo functions of Cdk1 have not been fully explored ..
  7. ncbi Insulin-like growth factor-1 receptor and its ligand regulate the reentry of adult ventricular myocytes into the cell cycle
    K Reiss
    Department of Medicine and Division of Cardiology, New York Medical College, Valhalla, New York 10595, USA
    Exp Cell Res 235:198-209. 1997
    ..The failure of IGF-1 to enhance cyclin B kinase activity may be responsible for a block in the cell cycle and the inability of myocytes to progress through the M phase and subsequently divide...
  8. ncbi Cyclin A2-CDK2 regulates embryonic gene activation in 1-cell mouse embryos
    Kentaro T Hara
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Shinryoiki Seimei Building 302, 5 1 5, Kashiwa no ha, Kashiwa shi, Chiba 277 8562, Japan
    Dev Biol 286:102-13. 2005
    ..When CDK2 activity or pronuclear accumulation of cyclin A2 was inhibited with CDK2 inhibitors or by microinjected siRNAs, ..
  9. ncbi Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes
    Laura A Jansen
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 46:1871-80. 2005
    ..Here, we investigated the hypothesis that impairment of potassium uptake through astrocyte inward rectifier potassium (Kir) channels may contribute to epileptogenesis in Tsc1(GFAP)CKO mice...
  10. ncbi The differential catalytic activity of alternatively spliced cdk2 alpha and cdk2 beta in the G1/S transition and early S phase
    T K Kwon
    Laboratory of Immunology, National Institute on Aging, NIH, Baltimore, Maryland 21224 2780, USA
    Exp Cell Res 238:128-35. 1998
    Progression through the G1/S transition of the cell cycle is regulated by cyclin E/cdk2 and cyclin A/cdk2 complexes. We demonstrate that there are two forms of murine cdk2 (cdk2 alpha and beta)...
  11. ncbi Cyclin A1 is required for meiosis in the male mouse
    D Liu
    Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Genet 20:377-80. 1998
    ..Cyclin A1 is therefore essential for spermatocyte passage into the first meiotic division in male mice, a function that cannot be complemented by the concurrently expressed B-type cyclins...
  12. ncbi Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation
    P Casaccia-Bonnefil
    Molecular Neurobiology, Skirball Institute for Biomolecular Medicine at NYU Medical Center, New York, NY 10016, USA nyu edu
    Development 126:4027-37. 1999
    ....
  13. ncbi Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice
    Sagrario Ortega
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Nat Genet 35:25-31. 2003
    We targeted the locus encoding the cyclin-dependent kinase 2 (CDK2) by homologous recombination in mouse embryonic stem (ES) cells...
  14. ncbi Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation
    Markus Welcker
    Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell 12:381-92. 2003
    ..We show that assembly of cyclin E into cyclin E-Cdk2 complexes is required in vivo for turnover by the Fbw7 pathway; that Cdk2 activity is required for cyclin E ..
  15. ncbi Cdk2 knockout mice are viable
    Cyril Berthet
    Regulation of Cell Growth Laboratory, National Cancer Institute, Building 560, 1050 Boyles St, Frederick, MD 21702 1201, USA
    Curr Biol 13:1775-85. 2003
    Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2/cyclin E complexes are thought to be required because they phosphorylate the retinoblastoma protein and drive cells through the G1/..
  16. ncbi Mouse development and cell proliferation in the absence of D-cyclins
    Katarzyna Kozar
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 118:477-91. 2004
    ..of cyclin D1(-/-)D2(-/-)D3(-/-) cells is resistant to the inhibition by p16(INK4a), but it critically depends on CDK2. Lastly, we found that cells lacking D-cyclins display reduced susceptibility to the oncogenic transformation...
  17. ncbi Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    Marcos Malumbres
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, E 28029 Madrid, Spain
    Cell 118:493-504. 2004
    ..These results indicate that D-type cyclin-dependent kinases are not essential for cell cycle entry and suggest the existence of alternative mechanisms to initiate cell proliferation upon mitogenic stimulation...
  18. ncbi Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation
    Cyril Berthet
    National Cancer Institute, Mouse Cancer Genetics Program, NCI Frederick, Building 560 22 56, 1050 Boyles Street, Frederick, Maryland 21702, USA
    Dev Cell 10:563-73. 2006
    Mouse knockouts of Cdk2 and Cdk4 have demonstrated that, individually, these genes are not essential for viability. To investigate whether there is functional redundancy, we have generated double knockout (DKO) mice...
  19. ncbi p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia
    Helena J M Smartt
    Department of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
    Gastroenterology 133:232-43. 2007
    ..Here, we addressed the role of p27 in untransformed intestinal epithelial cells in vivo and the consequence of its targeted inactivation...
  20. ncbi Cdk1 is sufficient to drive the mammalian cell cycle
    David Santamaria
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, E 28029 Madrid, Spain
    Nature 448:811-5. 2007
    ..cells are thought to require the sequential activation of at least four different cyclin-dependent kinases, Cdk2, Cdk3, Cdk4 and Cdk6, to drive cells through interphase, as well as Cdk1 to proceed through mitosis...
  21. pmc Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over
    Jeremy O Ward
    Middlebury College, Middlebury, Vermont, United States of America
    PLoS Genet 3:e139. 2007
    ..During late meiotic prophase in mei4 mutant males, absence of cyclin dependent kinase 2 and mismatch repair protein association from chromosome cores is correlated with the premature ..
  22. pmc Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone
    Beata Jablonska
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC 20010, USA
    J Cell Biol 179:1231-45. 2007
    We investigated the function of cyclin-dependent kinase 2 (Cdk2) in neural progenitor cells during postnatal development...
  23. doi Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4)
    Suzana Atanasoski
    Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    Mol Cell Neurosci 37:519-27. 2008
    ..In contrast, ablation of cdk2 and cdk6 had no significant influence on postnatal Schwann cell proliferation...
  24. pmc Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis
    Subbareddy Maddika
    Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, MB, R3E 0V9, Canada
    J Cell Sci 121:979-88. 2008
    Here, we show that CDK2, an S-phase cyclin-dependent kinase, is a novel target for Akt during cell cycle progression and apoptosis. Akt phosphorylates CDK2 at threonine 39 residue both in vitro and in vivo...
  25. ncbi Cyclin A-CDK activity during G1 phase impairs MCM chromatin loading and inhibits DNA synthesis in mammalian cells
    Leroy W Wheeler
    Department of Pharmacological Sciences at Saint Louis University, St Louis, Missouri 63104, USA
    Cell Cycle 7:2179-88. 2008
    ..Cyclin A-CDK2 and cyclin A-CDK1 phosphorylate nuclear substrates during S and G(2) phases, respectfully...
  26. doi CDK2 is required for proper homologous pairing, recombination and sex-body formation during male mouse meiosis
    Alberto Viera
    Unidad de Biologia Celular, Departamento de Biologia, Edificio de Ciencias Biológicas, Facultad de Ciencias, Universidad Autonoma de Madrid, Calle Darwin 2, 28049 Madrid, Spain
    J Cell Sci 122:2149-59. 2009
    Cyclin-dependent kinase 2 (CDK2) was assumed to be essential in the mammalian cell cycle both at the G1-S transition and throughout the S phase...
  27. pmc Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system
    Céline Caillava
    UMR S975, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Universite Pierre et Marie Curie Paris 6, Paris 75013, France
    J Cell Biol 193:397-407. 2011
    ..Type 2 cyclin-dependent kinase (Cdk2) controls cell cycle progression of OPCs, but whether it acts during myelination and repair of demyelinating ..
  28. pmc Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation
    Junko Odajima
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Dev Cell 21:655-68. 2011
    ..These results reveal a cell cycle-independent role for a core cell cycle protein, cyclin E, in synapse function and memory...
  29. doi Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells
    Shuhui Lim
    Institute of Molecular and Cell Biology IMCB, A STAR Agency for Science, Technology and Research, Singapore, Singapore
    Stem Cells 30:1509-20. 2012
    ..We generated Cdk2 and Cdk4 double knockout (DKO) mice and found a striking ablation of the intermediate zone and cortical plate in ..
  30. pmc RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis
    April Reynolds
    Howard Hughes Medical Institute, University of California, Davis, Davis, California, USA
    Nat Genet 45:269-78. 2013
    ..Haploinsufficiency indicates that RNF212 is a limiting factor for crossover control and raises the possibility that human alleles may alter the amount or stability of RNF212 and be risk factors for aneuploid conditions...
  31. pmc The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit
    Sabrina L Spencer
    Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA Electronic address
    Cell 155:369-83. 2013
    ..Here, we introduce a live-cell sensor for CDK2 activity and unexpectedly found that proliferating cells bifurcate into two populations as they exit mitosis...
  32. ncbi Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development
    F Zindy
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell Growth Differ 8:1139-50. 1997
    ..Therefore, p19INK4d may contribute to maintaining the quiescent state, acting as a buffer to prevent reactivation of cyclin D-dependent kinases in terminally differentiated cells...
  33. pmc Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice
    K L Auer
    Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Biochem J 336:551-60. 1998
    ..DeltaRaf:ER), the expression of p21Cip-1/WAF1 and p16INK4a CKI proteins increased, cyclin-dependent kinase 2 (cdk2) and cdk4 activities decreased, and DNA synthesis decreased...
  34. ncbi Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes
    R L Beijersbergen
    Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam
    Genes Dev 9:1340-53. 1995
    ..Consistent with this, we show that a cyclin D1/cdk4 complex, but not a cyclin E/cdk2 complex, can phosphorylate p107 in vivo...
  35. pmc A kinase associated with chromatin that can be activated by ligand-p185c-Neu or epidermal growth factor-receptor interactions
    A Samanta
    Center for Receptor Biology, University of Pennsylvania, School of Medicine, Philadelphia 19104 6082, USA
    Proc Natl Acad Sci U S A 92:6582-6. 1995
    ..to be a kinase, or tightly associated with a kinase, and shares antigenicity with the cell division cycle-dependent Cdk2 kinase as determined by antibody-dependent analysis...
  36. pmc C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice
    N A Timchenko
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 19:2936-45. 1999
    ..S-phase-specific E2F complexes containing E2F, DP, cdk2, cyclin A, and p107 are observed in the developing liver...
  37. pmc MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity
    Grant A McArthur
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Mol Cell Biol 22:3014-23. 2002
    ..cell lines derived from the Mad1/p27(KIP1) double-null mice, we observed constitutive Myc expression and cyclin E-CDK2 kinase activity as well as impaired differentiation following treatment with an inducer of differentiation...
  38. ncbi cAMP-dependent reorganization of the Cajal bodies and splicing machinery in cultured Schwann cells
    Rosario Fernandez
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain
    Glia 40:378-88. 2002
    ..This promitotic response is partially mediated by the Cdk2, which is required for the transition from the G1 to the S phase of the cell cycle...
  39. ncbi Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
    Ryosuke Tsunematsu
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Biol Chem 279:9417-23. 2004
    ..Expression of Notch1, -2, or -3 or of cyclin E was unaffected in Fbw7(-/-) embryos. Mammalian Fbw7 thus appears to play an indispensable role in negative regulation of the Notch4-Hey1 pathway and is required for vascular development...
  40. ncbi The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis
    Katherine Krupczak-Hollis
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607 7170, USA
    Dev Biol 276:74-88. 2004
    ....
  41. ncbi A role for PML3 in centrosome duplication and genome stability
    Zhi Xiang Xu
    Department of Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Mol Cell 17:721-32. 2005
    ..Specific knockdown of PML3 activates Cdk2/cyclin kinase activity...
  42. ncbi Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1)
    Alberto Martin
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, 28029 Madrid, Spain
    Cancer Cell 7:591-8. 2005
    p27(Kip1) and p21(Cip1) are thought to suppress tumor growth and prevent cell cycle progression by inhibiting Cdk2-cyclin E/A kinases...
  43. pmc CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development
    Everardo Macias
    Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27606, USA
    Am J Pathol 173:526-35. 2008
    It has been widely assumed that elevated CDK2 kinase activity plays a contributory role in tumorigenesis...
  44. pmc Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity
    Zakir Ullah
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 22:3024-36. 2008
    ..Furthermore, Cdk2(-/-) TS cells revealed that CDK2 is required for endoreduplication when CDK1 is inhibited...
  45. pmc Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression
    Utsav H Saxena
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Mol Cell Biol 29:2335-45. 2009
    ..In vitro, LSF is phosphorylated by cyclin E/cyclin-dependent kinase 2 (CDK2), cyclin C/CDK2, and cyclin C/CDK3, predominantly on S309...
  46. pmc Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E
    Said Akli
    Department of Experimental Radiation Oncology, University of Texas, MD Anderson Cancer Center, TX, USA
    Cancer Res 71:3377-86. 2011
    Cyclin E activates Cdk2, controls centrosome duplication, and regulates histone gene transcription...
  47. pmc Gap 1 phase length and mouse embryonic stem cell self-renewal
    Victor C Li
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:12550-5. 2012
    ..The resistance of murine ESCs to differentiation induced by lengthening G1 and/or the cell cycle could allow for separate control of these events and provide new opportunities for investigation and application...
  48. doi Superoxide dismutase induces G1-phase cell cycle arrest by down-regulated expression of Cdk-2 and cyclin-E in murine sarcoma S180 tumor cells
    Dongyue Liu
    Tianjin University of Science and Technology, Key Laboratory of Food Nutrition and Safety, Ministry of Education, Institute of Food Engineering and Biotechnology, Tianjin, China
    Cell Biochem Funct 31:352-9. 2013
    ..Together, our data confirmed that SOD could notably inhibit proliferation of S180 tumor cell and induce cell cycle arrest at G1-phase by down-regulating expressions of cyclin-E and Cdk-2...
  49. pmc Cerebellar cortical lamination and foliation require cyclin A2
    José Javier Otero
    The Ohio State University College of Medicine, Department of Pathology, Division of Neuropathology, 4169 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210, USA University of California, San Francisco Department of Pathology, Division of Neuropathology, USA Electronic address
    Dev Biol 385:328-39. 2014
    ..Although cyclin E1 has been reported to compensate for cyclin A2 function in fibroblasts and is upregulated in cyclin A2 null cerebella, cyclin E1 expression was unable to compensate for loss-of cyclin A2 function. ..
  50. doi Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice
    WenJing Liu
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China College of Life Science and Technology, Southwest University of Science and Technology, Mianyang, Sichuan 621000, China
    Dev Biol 392:108-16. 2014
    ..Here, we show that CDK2, especially p39(cdk2), as a potential meiosis-specific connector interaction with SUN1 mediates formation of ..
  51. pmc Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex
    Pavan Kumar P
    Weis Center for Research, Geisinger Clinic, Danville, United States
    elife 3:. 2014
    ..Our elucidation of CAPERα and UCA1 functions in vivo provides new insights into senescence induction, and the oncogenic and developmental properties of TBX3. ..
  52. pmc Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2
    William W Du
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, M4N 3M5, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5S 1A1, Canada
    Nucleic Acids Res 44:2846-58. 2016
    ..cell cycle progression by binding to the cell cycle proteins cyclin-dependent kinase 2 (also known as cell division protein kinase 2 or CDK2) and cyclin-dependent kinase inhibitor 1 (or p21), resulting in the formation of a ternary ..
  53. doi Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development
    Okkyung Rho
    Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Texas, USA
    J Invest Dermatol 136:2070-9. 2016
    ..Collectively, the current data using this unique mouse model provide further evidence that mTORC1 signaling in keratinocytes regulates key events in keratinocyte function and epithelial cancer development. ..
  54. ncbi Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes
    W G Morice
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905
    J Biol Chem 268:22737-45. 1993
    ..The inhibitory effects of RAP on the activation of cyclin E- and cyclin A-associated cyclin-dependent kinases suggest that one or both events participate in the regulation of T cell entry into S-phase...
  55. ncbi Formation of p27-CDK complexes during the human mitotic cell cycle
    T J Soos
    Program in Molecular Biology, Memorial Sloan Kettering Cancer Research Center, New York, New York 10021, USA
    Cell Growth Differ 7:135-46. 1996
    ..p27 associates with and inhibits cyclin/cycin-dependent kinase (CDK) holoenzymes containing either CDK4, CDK6, or CDK2. Although many different types of proliferating cells contain p27 protein, neither the interactions of p27 with ..
  56. ncbi Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage
    S E Ravnik
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, 79430, USA
    Dev Biol 207:408-18. 1999
    ..of the cyclin A1 and cyclin A2 proteins, as well as their candidate cyclin-dependent kinase partners, Cdk1 and Cdk2, in the spermatogenic lineage...
  57. ncbi Histone H1(S)-3 phosphorylation in Ha-ras oncogene-transformed mouse fibroblasts
    Deborah N Chadee
    Manitoba Institute of Cell Biology, 675 McDermot Avenue, Winnipeg, Manitoba, R3E 0V9 Canada
    Oncogene 21:8397-403. 2002
    ..of phosphorylated H1(S)-3 in the oncogene Ha-ras-transformed mouse fibroblasts was a consequence of an elevated Cdk2 activity rather than the reduced activity of a H1 phosphatase, which our studies suggest is PP1...
  58. ncbi Key role for cyclin-dependent kinases in the first and second meiotic divisions of rat spermatocytes
    Murielle Godet
    INSERM U418 INRA UMR 1245, Hopital Debrousse, 69322 Lyon 05, France
    Biol Reprod 70:1147-52. 2004
    ..When roscovitine, a potent inhibitor of CDK1, CDK2, and CDK5 activities, was added to cocultures of PS with Sertoli cells, the number of both secondary spermatocytes ..
  59. ncbi Characterization of murine gammaherpesvirus 68 v-cyclin interactions with cellular cdks
    Jason W Upton
    Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, Emory University School of Medicine, NE Atlanta, GA 30329, USA
    Virology 341:271-83. 2005
    ..the Kaposi's sarcoma-associated herpesvirus (KSHV) v-cyclin, the gammaHV68 v-cyclin preferentially interacts with cdk2 and cdc2 but does not interact with either cdk4 or cdk6...
  60. pmc Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication
    Hui Zhao
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Mol Cell Biol 32:1421-32. 2012
    ..To address whether CDK2 inhibitory phosphorylation plays a similar role in cell cycle regulation and checkpoint responses at the start of ..
  61. pmc Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion
    Miguel Ganuza
    Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    EMBO J 31:2498-510. 2012
    ..is completely dispensable for global transcription, is essential for the cell cycle via phosphorylation of Cdk1 and Cdk2. In vivo, Cdk7 is also indispensable for cell proliferation except during the initial stages of embryonic ..
  62. doi Cell cycle regulation in mouse heart during embryonic and postnatal stages
    Aiko Ikenishi
    School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, 683 8503, Japan
    Dev Growth Differ 54:731-8. 2012
    ..The data obtained should provide a basis for the analysis of cell cycle regulation in cardiomyocytes during embryonic and postnatal stages...
  63. pmc CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner
    Akihiro Yoshida
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630 0101, Japan
    Sci Rep 3:1054. 2013
    ..for interactors among various cell cycle regulators, and found that CSN5, but not the CSN holo-complex, bound to CDK2 in vivo and in vitro...
  64. ncbi Mitoinhibitory effects of the tumor promoter 2-acetylaminofluorene in rat liver: loss of E2F-1 and E2F-3 expression and cdk 2 kinase activity in late G1
    Lena C E Ohlson
    Natural Science Section, Södertörns högskola University College, P O Box 4101, 141 89 Huddinge, Sweden
    J Hepatol 40:957-62. 2004
    ..Examine the mitoinhibitory effect of the liver tumor promoter 2-acetylaminofluorene (2-AAF) in vivo, with focus on the proteins regulating G1- and S progression...
  65. ncbi A calmodulin-binding site on cyclin E mediates Ca2+-sensitive G1/s transitions in vascular smooth muscle cells
    Jaehyun Choi
    Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Faculty of Medicine, Department of Medicine, University of Toronto, Ontario, Canada
    Circ Res 98:1273-81. 2006
    ..Using buffers with differing [Ca2+], we found that the kinase activity of mouse and human cyclin E/CDK2, but not other G1/S-associated cell cycle complexes, was responsive to physiological changes in [Ca2+]...
  66. ncbi Inhibition of myogenesis by multiple cyclin-Cdk complexes. Coordinate regulation of myogenesis and cell cycle activity at the level of E2F
    K Guo
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Biol Chem 272:791-7. 1997
    ..E inhibits MCK expression only when they are co-expressed with their catalytic partner cyclin-dependent kinase 2 (Cdk2)...
  67. ncbi A mutant E2F-1 transcription factor that affects the phenotype of NIH3T3 fibroblasts inefficiency associates with cyclin A-cdk2
    K L Jordan-Sciutto
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biochem Cell Biol 76:37-44. 1998
    The amino-terminal domain of the E2F1 transcription factor is the site of association with cyclin A-cdk2, mapping to residues 87-94...
  68. ncbi Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3
    W M ElShamy
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Neuron 21:1003-15. 1998
    ..Our results provide evidence for novel activity of neurotrophins in cell cycle control and point toward an N-myc sensitization to cell death in the nervous system that is under the control of NT-3...
  69. pmc p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step
    P Zhang
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 13:213-24. 1999
    ....
  70. pmc Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice
    Y Geng
    Department of Cancer Biology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:194-9. 2001
    ..Here we report that ablation of p27(Kip1) restores essentially normal development in cyclin D1-deficient mice. Our results provide genetic evidence that p27(Kip1) functions downstream of cyclin D1...
  71. ncbi The long form of CDK2 arises via alternative splicing and forms an active protein kinase with cyclins A and E
    C Ellenrieder
    Paul Scherrer Institute, Institute for Medical Radiobiology, 5232 Villigen PSI, Switzerland
    DNA Cell Biol 20:413-23. 2001
    ..The complex of CDK2L with cyclin A has about half the specific activity of the equivalent CDK2-cyclin A complex...
  72. ncbi Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers
    C L Wu
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Cancer Res 61:7325-32. 2001
    Cyclin-dependent kinase 2 (cdk2) is a small serine/threonine kinase that regulates cell cycle progression. Cdk2 activity is tightly controlled by several mechanisms, including phosphorylation and dephosphorylation events...
  73. pmc Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4
    Luis M Schang
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Virol 76:7724-35. 2002
    ..Herein, we determined that neuronal expression of nuclear cdk2, cdk4, and cyclins E and D2 (which activate cdks 2 and 4, respectively) was induced following explant cultivation, ..
  74. ncbi GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress
    Mariappan Vairapandi
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cell Physiol 192:327-38. 2002
    ....
  75. ncbi The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein
    Christoph Geisen
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, Virchowstrasse 173, D 45122 Essen, Germany
    J Biol Chem 277:39909-18. 2002
    ..Here we show that cyclin E mutants defective to form an active kinase complex with Cdk2 are unable to drive cells from G(1) into S phase but can still malignantly transform rat embryo fibroblasts in ..
  76. ncbi A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication
    Pheruza Tarapore
    Department of Cell Biology, University of Cincinnati College of Medicine, P O Box 670521, Ohio 45267 0521, USA
    Cell Cycle 1:75-81. 2002
    ..show that the ability of G1/S extracts to induce centriole duplication in vitro depends on the presence of active CDK2/cyclin E...
  77. ncbi PKCeta associates with cyclin E/Cdk2 complex in serum-starved MCF-7 and NIH-3T3 cells
    Marat Shtutman
    Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University, Beer Sheva 84105, Israel
    Exp Cell Res 286:22-9. 2003
    ..Here we report that PKCeta associates with the cyclin E/Cdk2 complex...
  78. ncbi Early growth response gene 3 regulates thymocyte proliferation during the transition from CD4-CD8- to CD4+CD8+
    Hongkang Xi
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Immunol 172:964-71. 2004
    ..The results show that Egr3 is an important regulator of proliferation in response to pre-TCR signals, and that it also may regulate some specific aspects of differentiation...
  79. ncbi Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium
    Hina W Chaudhry
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 279:35858-66. 2004
    ..These results reveal a previously unrecognized critical role for cyclin A2 in mediating cardiomyocyte mitosis, a role that may significantly impact upon clinical treatment of damaged myocardium...
  80. ncbi Patterns of expression of cyclins A, B1, D, E and cdk 2 in preimplantation mouse embryos
    Ronald R Waclaw
    Department of Biology, Ball State University, Muncie, Indiana, USA
    Zygote 12:19-30. 2004
    ..Cdk 2 was present at consistent levels during G1 and S phases of all three cell cycles declining slightly in G2...
  81. ncbi Phosphorylation of Sp1 by cyclin-dependent kinase 2 modulates the role of Sp1 in CTP:phosphocholine cytidylyltransferase alpha regulation during the S phase of the cell cycle
    Claudia Banchio
    Department of Biochemistry, Canadian Institutes of Health Research Group in Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 279:40220-6. 2004
    ..M., and Vance, D. E. (2003) J. Biol. Chem. 278, 32457-32464). We now demonstrate that cyclin-dependent kinase 2 (CDK2) phosphorylation of Sp1 activates CTalpha transcription during S phase...
  82. ncbi Construction of a cyclin D1-Cdk2 fusion protein to model the biological functions of cyclin D1-Cdk2 complexes
    Anna Chytil
    Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 279:47688-98. 2004
    ..Cyclin D1-Cdk2 complexes were previously observed in human breast cancer cell lines, but their role in cell cycle regulation and ..
  83. ncbi Expression of cell cycle-related proteins in developing and adult mouse hippocampus
    Stefanie Schmetsdorf
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Int J Dev Neurosci 23:101-12. 2005
    ..Thus, they may have supplementary functions in differentiated neurons that might be associated with neuronal plasticity...
  84. ncbi Cdc2-cyclin E complexes regulate the G1/S phase transition
    Eiman Aleem
    Mouse Cancer Genetics Program, National Cancer Institute, NCI Frederick, Bldg 560 22 56, 1050 Boyles Street, Frederick, MD 21702 1201, USA
    Nat Cell Biol 7:831-6. 2005
    ..b>Cdk2 is the main target of p27 (refs 2, 3) and therefore we hypothesized that loss of Cdk2 activity should modify the ..
  85. ncbi Differential regulation of CDP/Cux p110 by cyclin A/Cdk2 and cyclin A/Cdk1
    Marianne Santaguida
    Molecular Oncology Group, McGill University Health Center, McGill University, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 280:32712-21. 2005
    Previous experiments with peptide fusion proteins suggested that cyclin A/Cdk1 and Cdk2 might exhibit similar yet distinct phosphorylation specificities. Using a physiological substrate, CDP/Cux, our study confirms this notion...
  86. pmc Compensation by tumor suppressor genes during retinal development in mice and humans
    Stacy L Donovan
    Department of Developmental Neurobiology, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    BMC Biol 4:14. 2006
    ..In this manuscript, we explore the different roles of the Rb family in human and mouse retinal development in order to better understand the species-specific difference in retinoblastoma susceptibility...
  87. ncbi CDK2 is required by MYC to induce apoptosis
    Debabrita Deb-Basu
    Division of Oncology, Department of Medicine, Stanford University, Stanford, California 94305 5151, USA
    Cell Cycle 5:1342-7. 2006
    ..We have found that cyclin-dependent kinase 2 (CDK2) is required by MYC to induce apoptosis...
  88. ncbi Maid (GCIP) is involved in cell cycle control of hepatocytes
    Eva Sonnenberg-Riethmacher
    ZMNH Centre for Molecular Neurobiology University of Hamburg, Hamburg, Germany
    Hepatology 45:404-11. 2007
    ..Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally...
  89. pmc Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation
    Xi Li
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:11597-602. 2007
    ..We show here that cdk2/cyclinA, whose expression is activated at the onset of S phase, functions in this capacity...
  90. pmc p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint
    Ande Satyanarayana
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    Mol Biol Cell 19:65-77. 2008
    Cdk1 was proposed to compensate for the loss of Cdk2. Here we present evidence that this is possible due to premature translocation of Cdk1 from the cytoplasm to the nucleus in the absence of Cdk2...
  91. pmc Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis
    Everardo Macias
    Center for Comparative Medicine and Translational Research, Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, North Carolina 27606, USA
    Cancer Res 67:9713-20. 2007
    ..showed that keratinocyte proliferation is mediated by CDK4 sequestration of p27Kip1 and p21Cip1, and activation of CDK2. Here, we studied the role of CDK2 in epithelial tumorigenesis...
  92. pmc TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung
    H Chen
    Developmental Biology Program, Dept of Surgery, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Eur Respir J 32:285-95. 2008
    ....
  93. doi Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
    Sven Falk
    Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Cell Stem Cell 2:472-83. 2008
    ..Thus, TGF-beta signaling controls the size of a specific brain area, the dorsal midbrain, by antagonizing canonical Wnt signaling and negatively regulating self-renewal of neuroepithelial stem cells...
  94. pmc Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyte proliferation
    Karishma M Fernandes
    Department of Nutrition, The University of North Carolina at Greensboro, Greensboro, North Carolina 27402, USA
    J Cell Biochem 105:913-21. 2008
    ..Finally, helenalin increased protein-protein interactions between p21 and cyclin-dependent kinase 2 (Cdk2) which may account in part for the anti-proliferative effect in 3T3-L1 preadipocytes.
  95. pmc Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17
    Min Deng
    Department of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 284:7875-88. 2009
    Cyclin E/Cdk2 is a key regulator in G(1)-S transition. We have identified a novel cyclin E/Cdk2 substrate called Ankrd17 (ankyrin repeat protein 17) using the TAP tag purification technique...
  96. doi Differential phosphorylation patterns between the Cyclin-A2/CDK2 complex and their monomers
    Juan Casado-Vela
    Protein Technology Unit, Biotechnology Programme, Spanish National Cancer Centre, Madrid, Spain
    Protein Expr Purif 66:15-21. 2009
    The Cyclin-A2/CDK2 is a protein heterodimer with kinase activity that plays a key role in centrosome duplication and meiotic cell division...
  97. pmc Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells
    Satoshi Nakayama
    Central Research Laboratories, Sysmex Corporation, 4 4 4, Takatsukadai, Nishi ku, Kobe, Japan
    Breast Cancer Res 11:R12. 2009
    ..We hypothesized that cyclin-dependent kinase (CDK) 1 activity and CDK2 activity in cancer cells, which reflect the activation state of the spindle assembly checkpoint and the growth ..
  98. pmc Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53
    V C Padmakumar
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute Frederick, Bldg 560 22 56, 1050 Boyles Street, Frederick, Maryland 21702 1201, USA
    Mol Cell Biol 29:2582-93. 2009
    ..In order to determine the role of proteins involved in G(1) control in tumorigenesis, we focused on Cdk2 and Cdk4, two cyclin-dependent kinases that in association with cyclin E and cyclin D promote the G(1)/S phase ..
  99. pmc Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo
    Eric A Hanse
    Division of Gastroenterology, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Cell Cycle 8:2802-9. 2009
    b>Cdk2 was once believed to play an essential role in cell cycle progression, but cdk2(-/-) mice have minimal phenotypic abnormalities...
  100. doi Cdk2 inhibition prolongs G1 phase progression in mouse embryonic stem cells
    Zuzana Koledova
    Department of Biology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic
    Stem Cells Dev 19:181-94. 2010
    ..Previous reports suggested that the rapid G1 phase progression of ESCs might be underpinned by high and precocious Cdk2 activity and that Cdk2 activity might be crucial for both cell-cycle regulation and cell-fate decisions in human ..
  101. pmc Protection of cisplatin cytotoxicity by an inactive cyclin-dependent kinase
    Rawad Hodeify
    Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Am J Physiol Renal Physiol 299:F112-20. 2010
    Cisplatin cytotoxicity is dependent on cyclin-dependent kinase 2 (Cdk2) activity in vivo and in vitro. A Cdk2 mutant (Cdk2-F80G) was designed in which the ATP-binding pocket was altered...

Research Grants7

  1. Transcriptional regulation of apoptosis
    JAMES MANFREDI; Fiscal Year: 2007
    ..abstract_text> ..
  2. FUNCTION OF A DUAL SPECIFICITY TRANSCRIPTION FACTOR
    Peter Hurlin; Fiscal Year: 2003
    ..Finally, gene targeting in the mouse will be used to study the biological activities of Mga and the individual roles of its bHLHZip domain and T-domain. ..
  3. The Role of Cyclin A in Cardiac Development
    HINA CHAUDHRY; Fiscal Year: 2006
    ..aim seeks to characterize molecular events that occur downstream of cyclin A binding to its kinase partners, cdk2 and cdc2...
  4. The identification and characterization of the mammalian mutation mei4
    Jeremy Ward; Fiscal Year: 2006
    ..The characterization of mei4 will not only contribute to our understanding of the basic molecular biology of meiosis but also increase our knowledge of important human health issues. [unreadable] [unreadable] [unreadable]..
  5. Myc Antagonism and Tumor Suppression by Mnt
    Peter Hurlin; Fiscal Year: 2008
    ..abstract_text> ..
  6. Genomic instability induced by the HPV-16 E7 oncoprotein
    Stefan Duensing; Fiscal Year: 2009
    ....
  7. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009
    ..Based on data obtained in this project, we are planning to start developing a strategy to correct liver proliferation in elderly. ..