Cdh2

Summary

Gene Symbol: Cdh2
Description: cadherin 2
Alias: CDHN, N-CAD, Ncad, cadherin-2, N-cadherin, neural cadherin
Species: mouse

Top Publications

  1. doi MMP-9 and -12 cause N-cadherin shedding and thereby beta-catenin signalling and vascular smooth muscle cell proliferation
    Amrita Dwivedi
    Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Cardiovasc Res 81:178-86. 2009
  2. pmc Regulation of N-cadherin dynamics at neuronal contacts by ligand binding and cytoskeletal coupling
    Olivier Thoumine
    CNRS, UMR 5091, Institut Magendie de Neurosciences, Universite Bordeaux 2, 33077 Bordeaux, France
    Mol Biol Cell 17:862-75. 2006
  3. doi Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
    Kentaro Hosokawa
    Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, Japan
    Blood 116:554-63. 2010
  4. ncbi Expression of N-cadherin mRNA during development of the mouse brain
    C Redies
    Department of Biochemistry, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Dev Dyn 197:26-39. 1993
  5. ncbi Cadherins regulate aggregation of pancreatic beta-cells in vivo
    U Dahl
    Department of Microbiology, University of Umea, Sweden
    Development 122:2895-902. 1996
  6. ncbi Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin
    Y Luo
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 128:459-69. 2001
  7. doi Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance
    Mark J Kiel
    Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Cell Stem Cell 1:204-17. 2007
  8. ncbi Effect of N-cadherin misexpression by the mammary epithelium in mice
    Karen A Knudsen
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    J Cell Biochem 95:1093-107. 2005
  9. ncbi Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
    Fumiyasu Imai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 133:1735-44. 2006
  10. ncbi N-cadherin mediates cortical organization in the mouse brain
    Masakazu Kadowaki
    Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto, 606 8501, Japan, and Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, The National Hospital, Oslo, Norway
    Dev Biol 304:22-33. 2007

Scientific Experts

Detail Information

Publications131 found, 100 shown here

  1. doi MMP-9 and -12 cause N-cadherin shedding and thereby beta-catenin signalling and vascular smooth muscle cell proliferation
    Amrita Dwivedi
    Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Cardiovasc Res 81:178-86. 2009
    ..In this study, we aimed to determine whether MMP-2, -9, -12, or -14 regulates VSMC proliferation via N-cadherin shedding...
  2. pmc Regulation of N-cadherin dynamics at neuronal contacts by ligand binding and cytoskeletal coupling
    Olivier Thoumine
    CNRS, UMR 5091, Institut Magendie de Neurosciences, Universite Bordeaux 2, 33077 Bordeaux, France
    Mol Biol Cell 17:862-75. 2006
    ..Finally, spontaneous neuronal contacts enriched in N-cadherin exhibited similar turnover rates, suggesting that such dynamics of N-cadherin may represent an intrinsic mechanism underlying the plasticity of neuronal adhesions...
  3. doi Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
    Kentaro Hosokawa
    Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, Japan
    Blood 116:554-63. 2010
    ..These findings suggest that N-cad-mediated cell adhesion is functionally required for the establishment of hematopoiesis in the BM niche after BM transplantation...
  4. ncbi Expression of N-cadherin mRNA during development of the mouse brain
    C Redies
    Department of Biochemistry, Max Planck Institute for Developmental Biology, Tubingen, Germany
    Dev Dyn 197:26-39. 1993
    ..Moreover, the results show that N-cadherin expression extends to phylogenetically newer structures, e.g., the mammalian neocortex...
  5. ncbi Cadherins regulate aggregation of pancreatic beta-cells in vivo
    U Dahl
    Department of Microbiology, University of Umea, Sweden
    Development 122:2895-902. 1996
    ..Thus, we have for the first time shown in vivo that cadherins regulate adhesive properties of beta-cells which are essential for the aggregation of endocrine cells into islets...
  6. ncbi Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin
    Y Luo
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 128:459-69. 2001
    ....
  7. doi Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance
    Mark J Kiel
    Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Cell Stem Cell 1:204-17. 2007
    ..These results question whether significant numbers of HSCs depend on N-cadherin-mediated adhesion to osteoblasts...
  8. ncbi Effect of N-cadherin misexpression by the mammary epithelium in mice
    Karen A Knudsen
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    J Cell Biochem 95:1093-107. 2005
    ..Tumors developed in +/neu and N-cadherin/neu mice, although few tumors in bitransgenic mice expressed N-cadherin, and they did not differ from N-cadherin-negative tumors...
  9. ncbi Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
    Fumiyasu Imai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 133:1735-44. 2006
    ..Therefore, we concluded that, at least in the later stages of neurogenesis, regulation of cell cycle exit is independent of adherens junctions...
  10. ncbi N-cadherin mediates cortical organization in the mouse brain
    Masakazu Kadowaki
    Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto, 606 8501, Japan, and Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, The National Hospital, Oslo, Norway
    Dev Biol 304:22-33. 2007
    ..These results demonstrate that N-cadherin is essential for maintaining the normal architecture of neuroepithelial or radial glial cells and that their disruption randomizes the internal structures of the cortex...
  11. pmc In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death
    M L Hermiston
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 129:489-506. 1995
    ..129/Sv embryonic stem (ES) cells, stably transfected with a dominant negative N-cadherin mutant (NCAD delta) under the control of a promoter that only functions in postmitotic enterocytes during their rapid, orderly, ..
  12. ncbi Cloning and expression analysis of a novel mesodermally expressed cadherin
    I Hoffmann
    Institut fur Saugetiergenetik, GSF Forschungszentrum Neuherberg, Oberschleissheim, Federal Republic of Germany
    Dev Biol 169:337-46. 1995
    ....
  13. pmc Identification of Evi-3, a novel common site of retroviral integration in mouse AKXD B-cell lymphomas
    M J Justice
    Division of Biology, Kansas State University, Manhattan 66506
    J Virol 68:1293-300. 1994
    ..Transcripts from Evi-3 are expressed in a developmentally regulated manner in B cells. Taken together, these data suggest that Evi-3 represents a novel proto-oncogene involved in mouse B-cell lymphomas...
  14. ncbi Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue
    J C Hutton
    Department of Biochemistry and Biophysics, University of California San Francisco 94143 0534
    Mol Endocrinol 7:1151-60. 1993
    ..Differences in CAD expression might explain the segregation of exocrine and endocrine cells during development of the pancreas and the characteristic morphological distribution of the different endocrine cells within the islet...
  15. ncbi Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion
    H Matsunami
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Biol 172:466-78. 1995
    ..These results suggest that cadherins confer region-specific adhesiveness on fetal brain cells and that this process may take part in brain segmentation...
  16. pmc The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones
    N Uchida
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    J Cell Biol 135:767-79. 1996
    ..The catenins localized in these junctions are likely associated with certain cadherin molecules including N-cadherin, and the cadherin/ catenin complex may play a critical role in the formation or maintenance of synaptic junctions...
  17. ncbi Developmental defects in mouse embryos lacking N-cadherin
    G L Radice
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Dev Biol 181:64-78. 1997
    ..These results show that N-cadherin plays a critical role in early heart development as well as in other morphogenetic processes...
  18. ncbi The expression patterns of guidance receptors, DCC and Neogenin, are spatially and temporally distinct throughout mouse embryogenesis
    J M Gad
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Dev Biol 192:258-73. 1997
    ..In summary, these observations indicate that Neogenin is the predominant member of this subfamily in mesodermal tissues, while DCC and Neogenin may play complementary roles in the generation of the fully functional CNS...
  19. ncbi Structure-function analysis of cell adhesion by neural (N-) cadherin
    K Tamura
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Neuron 20:1153-63. 1998
    ..Data from several laboratories imply that lateral dimerization or clustering of cadherins may increase their adhesivity. We suggest the possibility that the strand dimer may play a role in this activation...
  20. ncbi Cadherins and tissue formation: integrating adhesion and signaling
    K Vleminckx
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Bioessays 21:211-20. 1999
    ..We discuss how cadherins, through their effects on cell proliferation, cell death, cell polarization, and differentiation, play a role in the formation of tissues and organs in the developing embryo...
  21. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
  22. ncbi Adhesive subdivisions intrinsic to the epithelial somites
    K Horikawa
    Faculty of Science, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto, 606 8502, Japan
    Dev Biol 215:182-9. 1999
    ....
  23. ncbi The generation and in vivo differentiation of murine embryonal stem cells genetically null for either N-cadherin or N- and P-cadherin
    R Moore
    Department of Molecular Embryology, Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Int J Dev Biol 43:831-4. 1999
    ..differentiation was not seen for all tissues, however, as structures with a simple neural tube-like morphology were never found in teratomas lacking both N- and P-cadherin and organoid-like structures were rare in Ncad-/-tissue.
  24. ncbi Dosage requirement and allelic expression of PAX6 during lens placode formation
    C D van Raamsdonk
    Howard Hughes Medical Institute and Department of Molecular Biology, Princeton University, Princeton NJ 08544, USA
    Development 127:5439-48. 2000
    ..We propose instead that a critical threshold of PAX6 protein is required for lens placode formation and that the time in development at which this level is reached is delayed in heterozygotes...
  25. ncbi Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin
    J Rhee
    Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242 1342, USA
    J Biol Chem 276:6640-4. 2001
    ..Furthermore, among cells overexpressing the Y152F mutant endogenous PTP1B associates with N-cadherin and is tyrosine-phosphorylated...
  26. ncbi Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization
    Nhan L Tran
    Cancer Biology Graduate Program, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    J Biol Chem 277:32905-14. 2002
    ..We propose that N-cadherin homophilic adhesion can initiate anti-apoptotic signaling, which enhances the Akt cell survival pathway in metastatic cancer...
  27. pmc N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts
    Sophie Charrasse
    Centre de Recherche de Biochimie Macromoleculaire, 34293 Montpellier Cedex, France
    J Cell Biol 158:953-65. 2002
    ..We propose that cell-cell contacts formed via N-cadherin trigger signaling events that promote the commitment to myogenesis through the positive regulation of RhoA and negative regulation of Rac1, Cdc42Hs, and JNK activities...
  28. ncbi Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion
    Jinseol Rhee
    Department of Biological Sciences, The University of Iowa, Iowa City, IA 52242, USA
    Nat Cell Biol 4:798-805. 2002
    ..Local formation of such a receptor complex is an ideal mechanism to steer the growth cone while still allowing adhesion and growth in other directions...
  29. ncbi Cadherin-mediated adhesion is essential for myofibril continuity across the plasma membrane but not for assembly of the contractile apparatus
    Yang Luo
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Cell Sci 116:1471-9. 2003
    ..We conclude that a different adhesive system, most probably integrin, is responsible for myofibrillogenesis in the N-cadherin-null myocytes...
  30. ncbi A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations
    Philippe Marambaud
    Department of Psychiatry and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 114:635-45. 2003
    ..These data raise the possibility that FAD mutation-induced transcriptional abnormalities maybe causally related to the dementia associated with FAD...
  31. pmc Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
    Shernaz X Bamji
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:719-31. 2003
    ..This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion...
  32. ncbi Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways
    Julie Gavard
    Signalisation et Différenciation Cellulaires dans les Systèmes Nerveux et Musculaire, U440 INSERM UPMC, Institut du Fer a Moulin, 17 Rue du Fer a Moulin, 75005 Paris, France
    J Cell Sci 117:257-70. 2004
    ..These results provide additional information on the mechanisms by which cadherin coordinates adhesion with dynamic changes in the cytoskeleton to control cell shape and intercellular junction organization...
  33. ncbi Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis
    Charlles H M Castro
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, 216 S Kingshighway Blvd, St Louis, MO 63110, USA
    J Cell Sci 117:2853-64. 2004
    ..This results in decreased bone formation, delayed acquisition of peak bone mass and increased body fat...
  34. ncbi N-cadherin activation substitutes for the cell contact control in cell cycle arrest and myogenic differentiation: involvement of p120 and beta-catenin
    Julie Gavard
    Signalisation et Différenciation Cellulaires dans les Systèmes Nerveux et Musculaire, U440 INSERM UPMC, Institut du Fer a Moulin, 17 Rue du Fer a Moulin, 75005 Paris, France
    J Biol Chem 279:36795-802. 2004
    ..through controlled N-cadherin activation by plating isolated C2 myoblasts on surfaces coated with a chimeric Ncad-Fc homophilic ligand (N-cadherin ectodomain fused to the immunoglobulin G Fc fragment)...
  35. pmc Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization
    Ji Hye Paik
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 3501, USA
    Genes Dev 18:2392-403. 2004
    ..S1P-induced trafficking and activation of N-cadherin provides a novel mechanism for the stabilization of nascent blood vessels by mural cells and may be exploited to control angiogenesis and vascular diseases...
  36. ncbi N-cadherin is not essential for limb mesenchymal chondrogenesis
    Yang Luo
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Dyn 232:336-44. 2005
    ..We postulate that another cell adhesion molecule, possibly cadherin-11, is responsible for chondrogenesis in the N-cadherin-deficient limb...
  37. ncbi Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure
    Igor Kostetskii
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circ Res 96:346-54. 2005
    ..working myocardium, we generated a conditional knockout containing loxP sites flanking exon 1 of the N-cadherin (Cdh2) gene. Using a cardiac-specific tamoxifen-inducible Cre transgene, N-cadherin was deleted in the adult myocardium...
  38. pmc ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling
    Karina Reiss
    Biochemical Institute, Christian Albrechts University Kiel, Kiel, Germany
    EMBO J 24:742-52. 2005
    ....
  39. ncbi Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition
    Masato Maeda
    Department of Oral Biology College of Dentistry, University of Nebraska Medical Center, Omaha, NE 68198 7696, USA
    J Cell Sci 118:873-87. 2005
    ..Together, these data suggest that cadherin switching is necessary for increased motility but is not required for the morphological changes that accompany EMT...
  40. pmc N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis
    Yang Luo
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Cell Biol 169:29-34. 2005
    ..These findings provide a novel paradigm by which N-cadherin regulates angiogenesis, in part, by controlling VE-cadherin expression at the cell membrane...
  41. ncbi The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium
    Junlin Teng
    Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Cell Biol 7:474-82. 2005
    ..Furthermore, in KAP3-deficient cells, the subcellular localization of N-cadherin was disrupted. Taken together, these results suggest a potential tumour-suppressing activity for this molecular motor...
  42. ncbi Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis
    Jifen Li
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circ Res 97:474-81. 2005
    ..Our data suggest that perturbation of the N-cadherin/catenin complex in heart disease may be an underlying cause, leading to the establishment of the arrythmogenic substrate by destabilizing gap junctions at the cell surface...
  43. ncbi Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina
    Chieko Koike
    Department of Developmental Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Neurosci 25:10290-8. 2005
    ..Our data suggest that properly polarized photoreceptors anchor progenitors at the apical edge of the neural retina, which may be essential for building correct laminar organization of the retina...
  44. pmc alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway
    Wen Hui Lien
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 311:1609-12. 2006
    ..We propose that alphaE-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex...
  45. pmc Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and up-regulation of N-cadherin expression in mouse mammary epithelial cells
    Yasushi Shintani
    Department of Oral Biology, Eppley Institute for Research in Cancer and Allied Diseases, and Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 7696, USA
    Mol Biol Cell 17:2963-75. 2006
    ..In addition, we showed that cord formation and branching in three-dimensional culture (EMT-dependent events) required N-cadherin expression and PI3K-Rac1-JNK signaling...
  46. ncbi N-cadherin transsynaptically regulates short-term plasticity at glutamatergic synapses in embryonic stem cell-derived neurons
    Kay Jüngling
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, 44780 Bochum, Germany
    J Neurosci 26:6968-78. 2006
    ..This indicates a retrograde control of short-term plasticity by N-cadherin. In summary, our results revealed an unexpected involvement of a synaptic adhesion molecule in the regulation of short-term plasticity at glutamatergic synapses...
  47. ncbi Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice
    Chung Fang Lai
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 21:1897-906. 2006
    Ovariectomy-induced bone loss is accentuated in mice with germline Cdh2 haploinsufficiency, the result of a decreased osteoblastogenesis in the face of normal osteoclast number...
  48. pmc N-cadherin is required for neural crest remodeling of the cardiac outflow tract
    Yang Luo
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, 1355 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Biol 299:517-28. 2006
    ....
  49. ncbi Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm
    Natalia G Kan
    Max Planck Institut fur Immunbiologie, Abteilung für Molekulare Embryologie, Stubeweg 51, D 79108 Freiburg, Germany
    Development 134:31-41. 2007
    ..Thus, N-cadherin can maintain epithelia in differentiating ES cells, but not during the formation of the trophectoderm. Our results point to a specific and unique function for E-cadherin during mouse preimplantation development...
  50. ncbi Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization
    Helen M Phillips
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    Circ Res 101:137-45. 2007
    ..We propose that heterozygosity for mutations in different genes in the planar cell polarity pathway may be an important mechanism for congenital heart defects and cardiomyopathy in humans...
  51. ncbi Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors
    Mladen Roko Rasin
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nat Neurosci 10:819-27. 2007
    ..Thus, by regulating RGC adhesion and polarity, Numb and Numbl are required for the tissue architecture of neurogenic niches and the cerebral cortex...
  52. ncbi Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2
    Wenlai Zhou
    Howard Hughes Medical Institute and Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Nat Genet 39:1225-34. 2007
    ..Thus, we propose that transcriptional readout mediated at least in part by a Wnt11 --> ATF/CREB --> TGFbeta2 pathway is critical in regulating morphogenesis in response to noncanonical Wnt signaling...
  53. pmc Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 8:59. 2008
    ..Here, we examined the consequences of over-expression for the eye and its axonal connections...
  54. doi Differential requirement for beta-catenin in epithelial and fiber cells during lens development
    Sarah Cain
    Ocular Development Laboratory, Anatomy and Cell Biology Department, University of Melbourne, Victoria 3010, Australia
    Dev Biol 321:420-33. 2008
    ..These data indicate that beta-catenin plays distinct functions during lens fiber differentiation and is involved in both Wnt signaling and adhesion-related mechanisms that regulate lens epithelium and early fiber differentiation...
  55. pmc Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival
    Giuseppe F Pontoriero
    Department of Pathology and Molecular Medicine, McMaster University, ON, Canada
    Dev Biol 326:403-17. 2009
    ..These data suggest that the co-operative expression of both E- and N-cadherin during lens development is essential for normal cell sorting and subsequent lens vesicle separation...
  56. pmc N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation
    Eric Hay
    INSERM, U606, Paris, France
    Mol Cell Biol 29:953-64. 2009
    ..These data indicate that a previously unrecognized N-cadherin-axin-LRP5 interaction negatively regulates Wnt/beta-catenin signaling and is critical in the regulation of osteoblast function, bone formation, and bone mass...
  57. pmc Cortical neural precursors inhibit their own differentiation via N-cadherin maintenance of beta-catenin signaling
    Jianing Zhang
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Dev Cell 18:472-9. 2010
    ..These results suggest that neural precursor cell interactions can generate a self-supportive niche to regulate their own number...
  58. pmc N-cadherin mediates plasticity-induced long-term spine stabilization
    Pablo Mendez
    Department of Neuroscience, University of Geneva, Faculty of Medicine, Geneva, Switzerland
    J Cell Biol 189:589-600. 2010
    ..this study, we combined repetitive imaging and a gain and loss of function approach to test the role of N-cadherin (NCad) on spine stability...
  59. pmc N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover
    Jenny K Johansson
    Stem Cell Center, Department of Laboratory Medicine, Lund University, Sweden
    Genesis 48:374-81. 2010
    ..The number of insulin secretory granules is significantly reduced in N-cadherin-deficient beta-cells, and as a consequence insulin secretion is decreased...
  60. pmc Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation
    A Stan
    Institute for Neuro and Sensory Physiology, Biologisch Medizinisches Forschungszentrum, Heinrich Heine University Dusseldorf, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 107:11116-21. 2010
    ..This cooperation of two cell adhesion systems provides a mechanism for coupling bidirectional synapse maturation mediated by neuroligin-1 to cell type recognition processes mediated by classical cadherins...
  61. pmc N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms
    Adriana Di Benedetto
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8301, St Louis, MO 63110, USA
    J Cell Sci 123:2640-8. 2010
    We have previously shown that targeted expression of a dominant-negative truncated form of N-cadherin (Cdh2) delays acquisition of peak bone mass in mice and retards osteoblast differentiation; whereas deletion of cadherin 11 (Cdh11), ..
  62. pmc Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin
    Ozlem Bozdagi
    Fishberg Department of Neuroscience, Friedman Brain Institute and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurosci 30:9984-9. 2010
    ....
  63. doi The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool
    Dominik Herzog
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 31:5120-30. 2011
    ..Together, our data show that RhoA signaling is necessary for AJ regulation and for the maintenance of mammalian neuroepithelium organization preventing precocious cell-cycle exit and differentiation...
  64. pmc Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation
    Kei Ichi Katayama
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:7607-12. 2011
    ..These results demonstrate a critical role of RhoA in the maintenance of apical adherens junctions and the regulation of neural progenitor proliferation in the developing mammalian brain...
  65. pmc Cortactin is required for N-cadherin regulation of Kv1.5 channel function
    Lan Cheng
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 286:20478-89. 2011
    ..These data suggest that in addition to gap junction remodeling, aberrant Kv1.5 channel function contributes to the arrhythmogenic phenotype in N-cad CKO mice...
  66. pmc A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition
    Sara Howard
    MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 6:e23899. 2011
    ..Lastly we present data suggesting that cadherins are required for augmented activation of the Wnt/β-catenin pathway in vivo. This suggests that cadherins play a crucial role in β-catenin-dependent transcription...
  67. doi The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex
    Maki Asami
    Institute for Stem Cell Research, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764 Neuherberg Munich, Germany
    Development 138:5067-78. 2011
    ..Taken together, our work reveals several direct effects that the transcription factor Pax6 has on the machinery that mediates the orientation and mode of cell division...
  68. ncbi Neural cadherin: role in selective cell-cell adhesion
    S Miyatani
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Science 245:631-5. 1989
    Cadherins are a family of Ca2+-dependent intercellular adhesion molecules. Complementary DNAs encoding mouse neural cadherin (N-cadherin) were cloned, and the cell binding specificity of this molecule was examined...
  69. pmc Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects
    Elisabeth A Gustafson-Wagner
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 293:H2680-92. 2007
    ..The mXinalpha-knockout mouse line provides a novel model of cardiac hypertrophy and cardiomyopathy with conduction defects...
  70. doi Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin
    Stephen N Hartland
    MRC University of Edinburgh Centre for Inflammation Research, Edinburgh, UK
    Liver Int 29:966-78. 2009
    ..This is accompanied by HSC apoptosis. In this study, we examine a potential mechanism whereby MMP activity might induce HSC apoptosis by cleaving N-cadherin at the cell surface...
  71. ncbi Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas
    C J Møller
    Research Center for Medical Biotechnology, University of Copenhagen, Denmark
    Mol Endocrinol 6:1332-42. 1992
    ..In contrast, insulinoma cells are more islet-like in their phenotype and show less neuronal traits...
  72. ncbi Location of the 9257 and ataxia mutations on mouse chromosome 18
    A J Griffith
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor 48109 0618, USA
    Mamm Genome 7:417-9. 1996
    ..Two polymorphic microsatellite markers for proximal Chr 18 are described, D18Umi1 and D18Umi2. The Lama3 locus encoding the alpha 3 subunit of nicein was mapped distal to ataxia and did not recombine with Tg9257...
  73. pmc Fusion competence of myoblasts rendered genetically null for N-cadherin in culture
    C A Charlton
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Cell Biol 138:331-6. 1997
    ..These methods for obtaining genetically homozygous null somatic cells from adult tissues should have broad applications. Here, they demonstrate clearly that the putative fusion molecule, N-cadherin, is not essential for myoblast fusion...
  74. pmc RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration
    Kei Ichi Katayama
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Development 140:3139-45. 2013
    ..These findings provide genetic evidence that RhoA and Cdc42 are required in progenitors of the MGE in the VZ, but not the SVZ, for proper cortical interneuron migration. ..
  75. pmc Asymmetric N-cadherin expression results in synapse dysfunction, synapse elimination, and axon retraction in cultured mouse neurons
    Kim N Pielarski
    Institute of Neuro and Sensory Physiology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    PLoS ONE 8:e54105. 2013
    ..Thus, mis-match expression of N-cadherin might contribute to selective synaptic connectivity...
  76. ncbi The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species
    K Kaupmann
    Developmental Biology Unit, University of Bielefeld, Germany
    Genomics 14:488-90. 1992
    ..The gene order cen-Junb-Um-Tat-(Cdh3/Aprt) was determined. The human homologue CDH3 was mapped to chromosome 16q24.1-qter by analyzing human/mouse somatic cell hybrids...
  77. ncbi Mouse R-cadherin: expression during the organogenesis of pancreas and gastrointestinal tract
    A Sjodin
    Department of Microbiology, University of Umea, Sweden
    Exp Cell Res 221:413-25. 1995
    ..The subcellular localization in these tissues is on both the apical and basolateral surfaces. The potential function of R-cadherin, in particular its role in pancreas development, is discussed...
  78. ncbi Structural basis of cell-cell adhesion by cadherins
    L Shapiro
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
    Nature 374:327-37. 1995
    ..This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells...
  79. ncbi Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18
    R S Buxton
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, United Kingdom
    Genomics 21:510-6. 1994
    ..We further show that the human DSC3 gene, previously reported to be located on chromosome 9, also maps to human chromosome 18...
  80. ncbi N-cadherin protein distribution in normal embryos and in embryos carrying mutations in the homeobox gene Hoxa-4
    A I Packer
    Department of Genetics, The Center for Reproductive Sciences, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Dev Biol 41:459-68. 1997
    ....
  81. pmc Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    Y Liu
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1821, USA
    J Clin Invest 106:951-61. 2000
    ..Our data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development...
  82. ncbi TGFbeta2 in corneal morphogenesis during mouse embryonic development
    S Saika
    Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio, USA
    Dev Biol 240:419-32. 2001
    ..Delayed appearance of macrophages in ocular tissues was observed in Tgfb2(-/-) mice. Malfunctioning macrophages may account for accumulation of cell mass in vitreous of Tgfb2 null mice...
  83. ncbi Epigenetic silencing of E- and N-cadherins in the stroma of mouse thymic lymphomas
    M Matabuena de Yzaguirre
    Laboratorio de Genetica Molecular Humana, Departamento de Biologia, Universidad Autonoma de Madrid, 28049 Madrid, Espana
    Carcinogenesis 27:1081-9. 2006
    ..In addition, and contrary to what one would expect, N-cadherin (Cdh2) that is exclusively expressed by stromal cells is likewise down-regulated in most of the thymic lymphomas...
  84. ncbi Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning
    Kwang Won Seo
    Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, 77030, USA
    Dev Biol 290:200-10. 2006
    ....
  85. ncbi CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse
    Masayuki Uehara
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, Osaka 565 0871, Japan
    Dev Biol 302:399-411. 2007
    ....
  86. ncbi The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo
    Jeffrey D Lee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Development 134:2007-16. 2007
    ..We propose that mouse Lulu (Epb4.1l5) helps anchor the actin-myosin contractile machinery to the membrane to allow the dynamic rearrangements of epithelia that mediate embryonic morphogenesis...
  87. pmc N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility
    Jifen Li
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Mol Cell Cardiol 44:597-606. 2008
    Cardiac-specific deletion of the murine gene (Cdh2) encoding the cell adhesion molecule, N-cadherin, results in disassembly of the intercalated disc (ICD) structure and sudden arrhythmic death...
  88. pmc Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool
    N Spassky
    Universite Pierre and Marie Curie, IFR des Neurosciences, INSERM U711, Hopital Pitie Salpetriere, Paris, F 75013, France
    Dev Biol 317:246-59. 2008
    ..Dysfunctional cilia are associated with diverse human disorders including Bardet-Biedl and Joubert syndromes. Cerebellar abnormalities observed in these patients could be explained by defects in Shh-induced GCP expansion...
  89. doi Sox9 is required for invagination of the otic placode in mice
    Francisco Barrionuevo
    Institute of Human Genetics and Anthropology, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Dev Biol 317:213-24. 2008
    ....
  90. doi Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool
    Nina Solberg
    Section for Cellular and Genetic Therapy, Institute of Microbiology, Rikshospitalet, Oslo, Norway
    Dev Dyn 237:1799-811. 2008
    ..The lower number of progenitors in the dentate gyrus was not rescued after migration to the subgranular zone and thus the dentate gyrus lacked the entire internal blade and a part of the external blade from postnatal to adult stages...
  91. pmc Vang-like protein 2 and Rac1 interact to regulate adherens junctions
    Maria Lindqvist
    Neonatal Unit, Department of Woman and Child Health, SE 171 76, Stockholm, Sweden
    J Cell Sci 123:472-83. 2010
    ..We propose that Vangl2 affects cell adhesion and the cytoskeleton by recruiting Rac1 and targeting its activity in the cell to adherens junctions...
  92. pmc Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death
    Mellone N Marchong
    Campbell Family Institute for Cancer Research, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    PLoS Genet 6:e1000923. 2010
    ..These data suggest that Cdh11 displays tumor suppressor properties in vivo and in vitro in murine retinoblastoma through promotion of cell death...
  93. doi Developmental changes of cell adhesion molecule expression in the fetal mouse liver
    Yoshinori Sugiyama
    Department of Biology, Faculty of Science, Shizuoka University, Shizuoka City, Japan
    Anat Rec (Hoboken) 293:1698-710. 2010
    ..These results suggest that each cell adhesion molecule may play an important role during development in hepatic histogenesis, including hepatoblast/hepatocyte-stellate cell interactions, hemopoiesis, and bile duct morphogenesis...
  94. pmc N-cadherin cell-cell adhesion complexes are regulated by fibronectin matrix assembly
    Craig T Lefort
    Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 286:3149-60. 2011
    ....
  95. doi Intrinsic transition of embryonic stem-cell differentiation into neural progenitors
    Daisuke Kamiya
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Nature 470:503-9. 2011
    ..Thus, the transition of ES cell differentiation from the epiblast state into neuroectodermal progenitors specifically depends on the cell-intrinsic expression and activator function of Zfp521...
  96. doi SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis
    Pilar Esteve
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Nat Neurosci 14:562-9. 2011
    ..Together, these data indicate that Sfrps inhibit the ADAM10 metalloprotease, which might have important implications in pathological events, including cancer and Alzheimer's disease...
  97. pmc Calcium-dependent dynamics of cadherin interactions at cell-cell junctions
    Sally A Kim
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 108:9857-62. 2011
    ..These data indicate that cadherins can rapidly convey dynamic information about the extracellular environment to both cells that comprise a junction...
  98. doi Requirement for N-cadherin-catenin complex in heart development
    Oksana O Piven
    Іnstitute of Molecular Biology and Genetic, Kyiv, Ukraine
    Exp Biol Med (Maywood) 236:816-22. 2011
    ..Embryos lacking β-catenin in the heart also exhibited a cardiac defect, but only later in development resulting in partial lethality. These genetic studies underscore the importance of the N-cadherin/catenin complex in cardiogenesis...
  99. doi Impaired stria vascularis integrity upon loss of E-cadherin in basal cells
    Mark Oliver Trowe
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Dev Biol 359:95-107. 2011
    ....
  100. ncbi E-cadherin expression in a particular subset of sensory neurons
    K Shimamura
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Biol 152:242-54. 1992
    ..We suggest that this adhesion molecule may play a role in the selective adhesion of sensory neuronal fibers...