Cdh13

Summary

Gene Symbol: Cdh13
Description: cadherin 13
Alias: 4932416G01Rik, Cdht, Tcad, cadherin-13, H-cadherin, T-cadherin, heart cadherin
Species: mouse

Top Publications

  1. ncbi Characterization of cadherins expressed by murine thymocytes
    S B Munro
    Department of Surgery, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    Cell Immunol 169:309-12. 1996
  2. pmc T-cadherin is critical for adiponectin-mediated cardioprotection in mice
    Martin S Denzel
    Sanford Burnham Medical Research Institute, La Jolla, California, USA
    J Clin Invest 120:4342-52. 2010
  3. pmc Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice
    Ming Zhu
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 43:487-97. 2010
  4. pmc Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation
    Jason M Konter
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 188:854-63. 2012
  5. pmc Role of the adiponectin binding protein, T-cadherin (Cdh13), in allergic airways responses in mice
    Alison S Williams
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e41088. 2012
  6. pmc T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model
    Lionel W Hebbard
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Cancer Res 68:1407-16. 2008
  7. pmc T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
    Christopher Hug
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 101:10308-13. 2004
  8. ncbi Atypical GPI-anchored T-cadherin stimulates angiogenesis in vitro and in vivo
    Maria Philippova
    Cardiovascular Signalling Group, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Arterioscler Thromb Vasc Biol 26:2222-30. 2006
  9. pmc Role of the adiponectin binding protein, T-cadherin (cdh13), in pulmonary responses to subacute ozone
    David I Kasahara
    Department of Environmental Health, Harvard School of Public Health HSPH, Boston, Massachusetts, United States of America
    PLoS ONE 8:e65829. 2013
  10. pmc Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1
    Daisuke Kajimura
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell Metab 17:901-15. 2013

Scientific Experts

  • Maria Philippova
  • Tamotsu Takeuchi
  • Barbara Ranscht
  • Christopher Hug
  • David I Kasahara
  • Alison S Williams
  • Martin S Denzel
  • Kenneth Walsh
  • Stephanie A Shore
  • Ming Zhu
  • Isabel Martinez-Garay
  • O Rivero
  • Christophe Laumonnerie
  • Keisuke Matsuda
  • Frans van Roy
  • Jennifer L Parker-Duffen
  • Daisuke Kajimura
  • Kazuto Nakamura
  • Jason M Konter
  • Huiqing Si
  • Bjorn Tyrberg
  • Dennis Pfaff
  • Norah G Verbout
  • Elena Palmesino
  • E V Semina
  • Lionel W Hebbard
  • Salman R Khetani
  • Paul Erne
  • Kseniya Rubina
  • Michael R Akins
  • Paola Arlotta
  • Ulrich Mueller
  • Zhi Yong Huang
  • Cristina Gil-Sanz
  • Ana Espinosa
  • Thomas Niermann
  • Zoltan Molnar
  • Santos J Franco
  • L Bacmeister
  • Shunbun Kita
  • Hitoshi Nishizawa
  • Ayumu Hirata
  • Ryohei Sekimoto
  • Takuya Mori
  • Yu Tsushima
  • Norikazu Maeda
  • Yuya Fujishima
  • Shigeki Masuda
  • Kana Inoue
  • Ahmad Bechara
  • S Sich
  • D Kiser
  • Hiroki Kurihara
  • Iichiro Shimomura
  • T J Resink
  • Masaya Yamaoka
  • Tohru Funahashi
  • N Nadif Kasri
  • M Negwer
  • D Schubert
  • C Gross
  • K P Lesch
  • A G Schmitt
  • Nathalie Vilain
  • T Strekalova
  • S Popp
  • Yukiko Kurihara
  • D van den Hove
  • M M Selten
  • E Amendola
  • Filippo M Rijli
  • S M Kolk
  • F Proft
  • Shuxia Zhou
  • Leandro A Benedito
  • Sumiko Yoshida
  • J John Mann
  • Ronald A Depinho
  • Ulrich Tigges
  • Marcy Silver
  • Mathieu Ferron
  • X Edward Guo
  • Gerard Karsenty
  • Christopher J Clarke
  • Kyle J Riley
  • Ha Won Lee
  • Edward X Guo
  • Bin Zhou
  • Lester Kobzik
  • Emilio Arteaga-Solis

Detail Information

Publications30

  1. ncbi Characterization of cadherins expressed by murine thymocytes
    S B Munro
    Department of Surgery, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    Cell Immunol 169:309-12. 1996
    ..We speculate that cadherins will prove to play an essential role in the ontogeny of thymocytes...
  2. pmc T-cadherin is critical for adiponectin-mediated cardioprotection in mice
    Martin S Denzel
    Sanford Burnham Medical Research Institute, La Jolla, California, USA
    J Clin Invest 120:4342-52. 2010
    ..Here, we report that the glycosyl phosphatidylinositol–anchored cell surface glycoprotein T-cadherin (encoded by Cdh13) protects against cardiac stress through its association with APN in mice...
  3. pmc Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice
    Ming Zhu
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 43:487-97. 2010
    ..Our results indicate that adiponectin deficiency inhibits pulmonary inflammation induced by acute O(3) exposure, and that T-cadherin does not mediate the effects of adiponectin responsible for these events...
  4. pmc Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation
    Jason M Konter
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 188:854-63. 2012
    ..g., obesity) predispose to development of ALI through exaggerated inflammatory response in pulmonary vascular endothelium...
  5. pmc Role of the adiponectin binding protein, T-cadherin (Cdh13), in allergic airways responses in mice
    Alison S Williams
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e41088. 2012
    ..T-cadherin (T-cad; Cdh13) is a binding protein for the high molecular weight isoforms of adiponectin...
  6. pmc T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model
    Lionel W Hebbard
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Cancer Res 68:1407-16. 2008
    ..To test the function of T-cadherin in breast cancer, we inactivated the T-cadherin (Cdh13) gene in mice and evaluated tumor development and pathology after crossing the mutation into the mouse mammary ..
  7. pmc T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
    Christopher Hug
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 101:10308-13. 2004
    ..Because T-cadherin is a glycosylphosphatidylinositol-anchored extracellular protein, it may act as a coreceptor for an as-yet-unidentified signaling receptor through which adiponectin transmits metabolic signals...
  8. ncbi Atypical GPI-anchored T-cadherin stimulates angiogenesis in vitro and in vivo
    Maria Philippova
    Cardiovascular Signalling Group, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Arterioscler Thromb Vasc Biol 26:2222-30. 2006
    ..In vitro, overexpression and/or homophilic ligation of T-cad on endothelial cells (ECs) facilitates migration, proliferation, and survival. This study investigated T-cad effects on angiogenesis...
  9. pmc Role of the adiponectin binding protein, T-cadherin (cdh13), in pulmonary responses to subacute ozone
    David I Kasahara
    Department of Environmental Health, Harvard School of Public Health HSPH, Boston, Massachusetts, United States of America
    PLoS ONE 8:e65829. 2013
    ..Our results indicate that T-cadherin is required for the ability of adiponectin to suppress some but not all aspects of ozone-induced pulmonary inflammation...
  10. pmc Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1
    Daisuke Kajimura
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell Metab 17:901-15. 2013
    ..It also proposes that adiponectin regulation of bone mass occurs through a PI3-kinase-FoxO1 pathway...
  11. pmc T-cadherin is essential for adiponectin-mediated revascularization
    Jennifer L Parker-Duffen
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 288:24886-97. 2013
    ..These data highlight a previously unrecognized role for T-cadherin in limb revascularization and show that it is essential for mediating the vascular actions of adiponectin. ..
  12. doi Beyond E-cadherin: roles of other cadherin superfamily members in cancer
    Frans van Roy
    Department of Biomedical Molecular Biology, Ghent University, B 9052 Ghent, Belgium The Inflammation Research Center, VIB, B 9052 Ghent, Belgium
    Nat Rev Cancer 14:121-34. 2014
    ..These cadherins are very diverse in both structure and function, and their mutual interactions seem to influence biological responses in complex and versatile ways. ..
  13. pmc Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice
    Keisuke Matsuda
    Departments of Metabolic Medicine K M, Y F, N M, T M, A H, R S, Y T, S M, M Y, K I, H N, S K, T F, I S and Metabolism and Atherosclerosis A H, S K, T F, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan and 3Sanford Burnham Medical Research Institute B R, National Institutes of Health Designated Cancer Center, Development, Aging, and Regeneration Program, La Jolla, California 92037
    Endocrinology 156:934-46. 2015
    ..Recent work documented that Adipo locally associates with responsive tissues through interactions with T-cadherin (Tcad), an atypical, glycosylphosphatidylinositol (GPI)-anchored cadherin cell surface glycoprotein...
  14. doi Facial whisker pattern is not sufficient to instruct a whisker-related topographic map in the mouse somatosensory brainstem
    Christophe Laumonnerie
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel 4058, Switzerland
    Development 142:3704-12. 2015
    ..These results provide novel insights into periphery-dependent versus periphery-independent mechanisms of trigeminal ganglion and brainstem patterning in matching whisker topography. ..
  15. pmc Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition
    O Rivero
    ADHD Clinical Research Unit, Division of Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Wurzburg, Wurzburg, Germany
    Transl Psychiatry 5:e655. 2015
    Cadherin-13 (CDH13), a unique glycosylphosphatidylinositol-anchored member of the cadherin family of cell adhesion molecules, has been identified as a risk gene for attention-deficit/hyperactivity disorder (ADHD) and various comorbid ..
  16. pmc Cadherin 2/4 signaling via PTP1B and catenins is crucial for nucleokinesis during radial neuronal migration in the neocortex
    Isabel Martinez-Garay
    Molecular and Cellular Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Development 143:2121-34. 2016
    ..Taken together, our findings indicate that cadherin-mediated signaling to the cytoskeleton is crucial for nucleokinesis of neocortical projection neurons during their radial migration. ..
  17. pmc T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion
    Bjorn Tyrberg
    Sanford Burnham Medical Research Institute, Orlando, FL, USA
    Islets 3:327-37. 2011
    ..We report the association of the cell-adhesion and adiponectin (APN)-binding glycoprotein T-cadherin (Cdh13) with insulin granules in mouse and human β-cells...
  18. pmc Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling
    Elena Palmesino
    Neural Circuit Development Laboratory, Institut de Recherches Cliniques de Montreal, Montreal, Canada
    PLoS Biol 8:e1000446. 2010
    ..Together, these observations point to identical transcription factors that control motor axon guidance and soma migration and reveal the molecular hierarchy of myotopic organisation...
  19. doi Paradoxical effects of T-cadherin on squamous cell carcinoma: up- and down-regulation increase xenograft growth by distinct mechanisms
    Dennis Pfaff
    Department of Biomedicine, Laboratory for Signal Transduction, Basel University Hospital, Switzerland
    J Pathol 225:512-24. 2011
    ..Silencing or up-regulation of T-cad in A431 (shTcad or Tcad(+) , respectively) both resulted in increased tumour expansion in vivo...
  20. ncbi T-cadherin activates Rac1 and Cdc42 and changes endothelial permeability
    E V Semina
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, 121552, Russia
    Biochemistry (Mosc) 74:362-70. 2009
    ..Moreover, suppression of the T-cadherin expression significantly decreased the endothelial monolayer permeability as compared to the control (p < 0.001)...
  21. pmc T-cadherin modulates hepatocyte functions in vitro
    Salman R Khetani
    Laboratory for Multiscale Regenerative Technologies, Massachusetts Institute of Technology, 77 Massachusetts Ave, E19 502D, Cambridge, MA 02139, USA
    FASEB J 22:3768-75. 2008
    ..Our work suggests potential avenues for investigating the role of T-cadherin on hepatocellular function in vivo in settings such as embryogenesis and liver pathology...
  22. ncbi T-cadherin suppresses angiogenesis in vivo by inhibiting migration of endothelial cells
    Kseniya Rubina
    Department of Biological and Medical Chemistry, Faculty of Fundamental Medicine, Lomonosov Moscow State University, 31 5, Lomonosovsky av, Moscow, 119192, Russia
    Angiogenesis 10:183-95. 2007
    ..These data suggest that T-cadherin expressed in the stroma could act as a negative guidance cue for the ingrowing blood vessels and thus could have an important potential therapeutic application...
  23. ncbi Cadherin expression in the developing mouse olfactory system
    Michael R Akins
    Interdepartmental Neuroscience Graduate Program, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Comp Neurol 501:483-97. 2007
    ..CDH2, CDH4, and CDH6 are expressed within neuropil. CDH2, CDH4, CDH6, CDH8, CDH10, CDH11, and CDH13 are expressed by projection neurons within the main and accessory OBs...
  24. ncbi Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo
    Paola Arlotta
    MGH HMS Center for Nervous System Repair, Departments of Neurosurgery and Neurology, Program in Neuroscience and Harvard Stem Cell Institute, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuron 45:207-21. 2005
    ....
  25. ncbi Aryl hydrocarbon receptor ligands repress T-cadherin expression in vascular smooth muscle cells
    Thomas Niermann
    Department of Research, Cardiovascular Laboratories, ZLF 320, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Biochem Biophys Res Commun 300:943-9. 2003
    ..Regulation of adhesion proteins through the AHR pathway may represent a novel mechanism of action by atherogenic polycyclic aromatic hydrocarbons...
  26. pmc T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21(CIP1/WAF1) expression
    Zhi Yong Huang
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 23:566-78. 2003
    ..Collectively, these observations suggest a novel mechanism of growth regulation for T-cadherin involving p21(CIP1/WAF1) expression and G2 arrest...
  27. ncbi Expression of T-cadherin in Basal keratinocytes of skin
    Shuxia Zhou
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Invest Dermatol 118:1080-4. 2002
    ....
  28. ncbi Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells
    T Takeuchi
    Department of Pathology, Kochi Medical School, Japan
    J Neurochem 74:1489-97. 2000
    ..Epidermal growth factor is known to be required for proliferation of neural stem cells. This finding, together with those of the present study, suggests that T-cadherin functions as a negative regulator of neural cell growth...
  29. ncbi Molecular properties and chromosomal location of cadherin-8
    M Kido
    Doheny Eye Institute, University of Southern California School of Medicine, Los Angeles 90033, USA
    Genomics 48:186-94. 1998
    ..Cadherin-8, as well as cadherin-11, was mapped to a specific region of chromosome 8 that also includes cadherins-1, -3, and -5...