Cdh1

Summary

Gene Symbol: Cdh1
Description: cadherin 1
Alias: AA960649, ARC-1, E-cad, Ecad, L-CAM, UVO, cadherin-1, E-cadherin, epithelial cadherin, uvomorulin
Species: mouse

Top Publications

  1. ncbi Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
    Patrick W B Derksen
    Division of Molecular Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Cancer Cell 10:437-49. 2006
  2. pmc 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal
    Kalpana Ghoshal
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell Biol 25:4727-41. 2005
  3. pmc Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse
    Hehai Wang
    Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, 1125 MRB IV, 2215 B Garland Avenue, Nashville, TN 37232 0656, USA
    Dev Biol 318:112-25. 2008
  4. pmc Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles
    Danelle Devenport
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Nat Cell Biol 10:1257-68. 2008
  5. ncbi Structural basis of calcium-induced E-cadherin rigidification and dimerization
    B Nagar
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Nature 380:360-4. 1996
  6. pmc Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    Y Liu
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1821, USA
    J Clin Invest 106:951-61. 2000
  7. pmc p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7
    Laura De Rosa
    CEINGE Biotecnologie Avanzate, Via Comunale Margherita 482, 80145 Napoli, Italy
    J Biol Chem 284:30574-82. 2009
  8. pmc Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1
    Anne Christine Hick
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    BMC Dev Biol 9:66. 2009
  9. pmc Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape
    Nan Tang
    Department of Anatomy, University of California, San Francisco, CA 94158, USA
    Science 333:342-5. 2011
  10. pmc Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly
    Frauke Drees
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:903-15. 2005

Research Grants

Detail Information

Publications191 found, 100 shown here

  1. ncbi Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
    Patrick W B Derksen
    Division of Molecular Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Cancer Cell 10:437-49. 2006
    ..Moreover, loss of E-cadherin induced anoikis resistance and facilitated angiogenesis, thus promoting metastatic disease. Our results suggest that loss of E-cadherin contributes to both mammary tumor initiation and metastasis...
  2. pmc 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal
    Kalpana Ghoshal
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell Biol 25:4727-41. 2005
    ..Overexpression of the substrate recognition component, Cdh1 but not Cdc20, of APC (anaphase-promoting complex)/cyclosome ubiquitin ligase reduced the level of Dnmt1 in both ..
  3. pmc Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse
    Hehai Wang
    Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, 1125 MRB IV, 2215 B Garland Avenue, Nashville, TN 37232 0656, USA
    Dev Biol 318:112-25. 2008
    ..These results provide the first evidence that ZO-1 is involved in blastocyst formation from the morula by regulating accumulation of fluid and differentiation of nonpolar blastomeres to polar trophoblast cells...
  4. pmc Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles
    Danelle Devenport
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Nat Cell Biol 10:1257-68. 2008
    ..Finally, we provide in vitro evidence that homotypic intracellular interactions of Celsr1 are required to recruit Vangl2 and Fzd6 to sites of cell-cell contact...
  5. ncbi Structural basis of calcium-induced E-cadherin rigidification and dimerization
    B Nagar
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Nature 380:360-4. 1996
    ..They participate in the maintenance of proper cell-cell contacts: for example, reduced levels of epithelial cadherin (E-cadherin) correlate with increased invasiveness in many human tumour cell types...
  6. pmc Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    Y Liu
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1821, USA
    J Clin Invest 106:951-61. 2000
    ..Our data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development...
  7. pmc p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7
    Laura De Rosa
    CEINGE Biotecnologie Avanzate, Via Comunale Margherita 482, 80145 Napoli, Italy
    J Biol Chem 284:30574-82. 2009
    ..Our data indicate that p63 prevents ectopic expression of non-epidermal genes by a mechanism involving Smad7 repression and, to a lesser extent, Bmp7 induction, with consequent enhancement of BMP/Smad signaling...
  8. pmc Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1
    Anne Christine Hick
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    BMC Dev Biol 9:66. 2009
    ..The morphogenic mechanisms by which the ductal network is established as well as the signaling pathways involved in this process are poorly understood...
  9. pmc Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape
    Nan Tang
    Department of Anatomy, University of California, San Francisco, CA 94158, USA
    Science 333:342-5. 2011
    ....
  10. pmc Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly
    Frauke Drees
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:903-15. 2005
    ..These results indicate a new role for alpha-catenin in local regulation of actin assembly and organization at sites of cadherin-mediated cell-cell adhesion...
  11. pmc Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2
    Eric T Domyan
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 138:971-81. 2011
    ....
  12. doi Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal
    Francesca Soncin
    Core Technology Facility, Faculty of Medical and Human Sciences, and The University of Manchester, Manchester, United Kingdom
    Stem Cells 27:2069-80. 2009
    ..We show that inhibition of E-cadherin-mediated cell-cell contact in ES cells using gene knockout (Ecad(-/-)), RNA interference (EcadRNAi), or a transhomodimerization-inhibiting peptide (CHAVC) results in cellular ..
  13. pmc A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development
    D Riethmacher
    Max Delbrueck Laboratorium, Max Planck Gesellschaft, Koeln, Germany
    Proc Natl Acad Sci U S A 92:855-9. 1995
    ..Thus, maternal E-cadherin suffices for initial compaction of the morula but not for further preimplantation development to occur...
  14. ncbi Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney
    Eman Naim
    Department of Anatomy and Cell Biology, Monash University, Clayton, Victoria, Australia
    Kidney Int 68:955-65. 2005
    ..The aim of this study was to investigate the role of the epithelial polarity gene, discs large 1 (dlg1), during development of the mouse kidney...
  15. pmc Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development
    Jianliang Xu
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
    Mol Cell Biol 28:1669-78. 2008
    ..Thus, ZO-2 is required for mouse embryonic development, but ZO-3 is dispensable. This is to our knowledge the first report showing that an individual ZO protein plays a nonredundant and critical role in mammalian development...
  16. pmc AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis
    Xuan Wang
    The Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    J Cell Biol 183:37-48. 2008
    ....
  17. pmc beta-Catenin promotes respiratory progenitor identity in mouse foregut
    Kelley S Harris-Johnson
    Laboratory of Genetics and Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:16287-92. 2009
    ..Our findings reveal an early role for beta-Catenin in the establishment of respiratory progenitors in mouse foregut endoderm...
  18. pmc Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA
    Development 138:1395-407. 2011
    ..Indeed, genetic activation of Notch partially rescues Eya1(-/-) lung epithelial defects. These findings uncover novel functions for Eya1 as a crucial regulator of the complex behavior of distal embryonic lung epithelium...
  19. pmc Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome
    Tom Van de Putte
    Department of Developmental Biology, Flanders Interuniversity Institute for Biotechnology, and Laboratory of Molecular Biology Celgen, University of Leuven, Leuven, Belgium
    Am J Hum Genet 72:465-70. 2003
    ..Furthermore, we show that Sip1 is involved in the specification of neuroepithelium...
  20. pmc Abnormal placental development and early embryonic lethality in EpCAM-null mice
    Keisuke Nagao
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 4:e8543. 2009
    ..EpCAM has been extensively studied as a potential tumor marker and immunotherapy target, and more recent studies suggest that EpCAM expression may be characteristic of cancer stem cells...
  21. ncbi Developmental patterning of the circumvallate papilla
    Suwanna Jitpukdeebodintra
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033, USA
    Int J Dev Biol 46:755-63. 2002
    ....
  22. ncbi Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development
    R Szabo
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 26:1546-56. 2007
    ..Furthermore, matriptase/HAI-1 double-deficient mice were phenotypically indistinguishable from matriptase single-deficient littermates...
  23. pmc SOX9 is required for maintenance of the pancreatic progenitor cell pool
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 104:1865-70. 2007
    ..These findings will be of major significance for the development of in vitro protocols for cell replacement therapies...
  24. ncbi The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
    ..This network operating at the onset of liver development contains candidate genes for investigation of liver carcinogenesis...
  25. pmc E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles
    Peter Young
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    EMBO J 22:5723-33. 2003
    ..We conclude that E-cadherin is required for maintaining the adhesive properties of adherens junctions in keratinocytes and proper skin differentiation. Furthermore, continuous hair follicle cycling is dependent on E-cadherin...
  26. doi Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary
    Anne Amandine Chassot
    INSERM, U636, F 06108 Nice, France
    Hum Mol Genet 17:1264-77. 2008
    ..Thus, a balance between Sox9 and beta-catenin activation determines the fate of the gonad, with Rspo1 acting as a crucial regulator of canonical beta-catenin signaling required for female development...
  27. ncbi FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak
    B Ciruna
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Dev Cell 1:37-49. 2001
    ..We propose that modulation of cytoplasmic beta-catenin levels, associated with FGF-induced downregulation of E-cadherin, provides a molecular link between FGF and Wnt signaling pathways at the streak...
  28. ncbi E-cadherin is a survival factor for the lactating mouse mammary gland
    Oreda Boussadia
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Mech Dev 115:53-62. 2002
    ..Mice with homozygous loxP sites in both alleles of the E-cadherin (Cdh1) gene were generated and these mice were crossed with transgenic mice with the Cre recombinase under the control of ..
  29. ncbi Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis
    Vaishali N Patel
    Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD, USA
    Development 134:4177-86. 2007
    ..In summary, our results show heparanase releases FGF10 from perlecan HS in the basement membrane, increasing MAPK signaling, epithelial clefting, and lateral branch formation, which results in increased branching morphogenesis...
  30. doi Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin
    Robert Odell Stephenson
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Development 137:3383-91. 2010
    ..We show here that in mouse embryos completely lacking both maternal and zygotic E-cadherin (cadherin 1), the normal epithelial morphology of outside cells is disrupted, but individual cells still initiate TE- and ..
  31. ncbi Lim 1 is required for nephric duct extension and ureteric bud morphogenesis
    Anissa Pedersen
    Department of Genetics, Cell Biology and Development and University of Minnesota Developmental Biology Center, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Dev Biol 288:571-81. 2005
    ..These results suggest that Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining the differentiation of the nephric epithelium...
  32. ncbi Cadherins regulate aggregation of pancreatic beta-cells in vivo
    U Dahl
    Department of Microbiology, University of Umea, Sweden
    Development 122:2895-902. 1996
    ..Thus, we have for the first time shown in vivo that cadherins regulate adhesive properties of beta-cells which are essential for the aggregation of endocrine cells into islets...
  33. ncbi Lack of beta-catenin affects mouse development at gastrulation
    H Haegel
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Development 121:3529-37. 1995
    ..Our results demonstrate that, although beta-catenin is expressed rather ubiquitously, it is specifically required in the ectodermal cell layer...
  34. ncbi Systematic analysis of E-, N- and P-cadherin expression in mouse eye development
    Li Xu
    Department of Ophthalmology, Mason Eye Institute, One Hospital Drive, Columbia, MO 65212, USA
    Exp Eye Res 74:753-60. 2002
    ..E-cadherin expression in the neural retina has not been reported before. This study shows that cell fate determination in the eye occurs in conjunction with distinct changes in the patterns of cadherin gene expression...
  35. pmc Cell-autonomous requirements for Dlg-1 for lens epithelial cell structure and fiber cell morphogenesis
    Charlene Rivera
    Department of Anatomy, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Dev Dyn 238:2292-308. 2009
    ..These fiber cell defects were recapitulated when Dlg-1 was disrupted only in fiber cells. These results suggest that Dlg-1 acts in a cell autonomous manner to regulate epithelial cell structure and fiber cell differentiation...
  36. pmc Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesis
    Nils O Lindström
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Gene Expr Patterns 11:221-32. 2011
    ..This detailed study of the spatial and temporal expression of LIMK1 shows that LIMK1 expression is more dynamic than previously reported, in particular at sites of tissue-tissue interactions guiding multiple developmental processes...
  37. doi SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes
    Jelena Kocic
    Laboratory for Experimental Hematology, Institute for Medical Research, University of Belgrade, Dr Subotica 4, PO Box 102, 11129 Belgrade, Serbia
    Eur J Cancer 48:1550-7. 2012
    ....
  38. pmc Renal collecting system growth and function depend upon embryonic γ1 laminin expression
    Dong Hua Yang
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Development 138:4535-44. 2011
    ....
  39. pmc The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear
    Tiia Ponnio
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:935-45. 2002
    ....
  40. ncbi The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation
    Henrik Fagman
    Institute of Anatomy and Cell Biology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Dev Dyn 235:444-55. 2006
    ..It is suggested that thyroid inductive signals arise from embryonic vessels, and that this provides ideas to conceptually new pathogenetic mechanisms of thyroid dysgenesis...
  41. ncbi Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine development
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    J Histochem Cytochem 55:1075-88. 2007
    ..These results indicated that murine thyroid C cells are derived from the endodermal epithelial cells of the fourth pharyngeal pouch and do not originate from neural crest cells...
  42. pmc PLEKHA7 is an adherens junction protein with a tissue distribution and subcellular localization distinct from ZO-1 and E-cadherin
    Pamela Pulimeno
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    PLoS ONE 5:e12207. 2010
    ....
  43. pmc In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1
    Daniel Silberschmidt
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Napoli, Italy
    BMC Dev Biol 11:9. 2011
    ..We have generated mouse mutant strains to assess the roles of the two activation domains and of phosphorylation in mouse development and differentiation...
  44. pmc E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
    J Hülsken
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 127:2061-9. 1994
    ....
  45. ncbi Wnt-1-dependent regulation of local E-cadherin and alpha N-catenin expression in the embryonic mouse brain
    K Shimamura
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Development 120:2225-34. 1994
    ..This mechanism may contribute to the patterning of the expression of these adhesion-related proteins in the embryonic brain...
  46. pmc E-cadherin null mutant embryos fail to form a trophectoderm epithelium
    L Larue
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Proc Natl Acad Sci U S A 91:8263-7. 1994
    ..These results demonstrate the pivotal role of E-cadherin in one of the most basic morphogenetic events in the development of multicellular organisms, the biogenesis of an epithelium...
  47. ncbi Optical projection tomography as a tool for 3D microscopy and gene expression studies
    James Sharpe
    Medical Research Council, Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Science 296:541-5. 2002
    ..OPT microscopy allows the rapid mapping of the tissue distribution of RNA and protein expression in intact embryos or organ systems and can therefore be instrumental in studies of developmental biology or gene function...
  48. pmc ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation
    Thorsten Maretzky
    Biochemical Institute and Department of Dermatology, Christian Albrechts University Kiel, D 24098 Kiel, Germany
    Proc Natl Acad Sci U S A 102:9182-7. 2005
    ..Our data strongly suggest that this protease constitutes a major regulatory element for the multiple functions of E-cadherin under physiological as well as pathological conditions...
  49. ncbi Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland
    Michael A Davis
    Department of Cancer Biology, Vanderbilt University, 438 Preston Building, Nashville, Tennessee 37232, USA
    Dev Cell 10:21-31. 2006
    ..The data reveal an unexpected role for p120 in salivary acinar development and show that p120 ablation by itself induces effects consistent with a role in tumor progression...
  50. doi Steel factor controls primordial germ cell survival and motility from the time of their specification in the allantois, and provides a continuous niche throughout their migration
    Ying Gu
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Development 136:1295-303. 2009
    ....
  51. pmc Epithelial dynamics of pancreatic branching morphogenesis
    Alethia Villasenor
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Development 137:4295-305. 2010
    ..Overall, these results illustrate distinct, step-wise cellular mechanisms by which pancreatic epithelium shapes itself to create a functional branching organ...
  52. pmc Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation
    Aimin Jiang
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, CT 06520, USA
    Immunity 27:610-24. 2007
    ..These DCs induced tolerance in vivo and may thus contribute to the elusive steady-state "tolerogenic DCs."..
  53. ncbi Zonula occludens-1 and E-cadherin are coordinately expressed in the mouse uterus with the initiation of implantation and decidualization
    B C Paria
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas, 66160 7338, USA
    Dev Biol 208:488-501. 1999
    ....
  54. pmc Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2
    Alysia L VandenBerg
    Universite Pierre et Marie Curie Paris VI, 75634 Paris Cedex 13, France
    Development 136:1559-70. 2009
    ..These studies demonstrate that the establishment and maintenance of cell polarity through non-canonical Wnt signaling are required for FRT development...
  55. pmc Tissue restricted expression and chromosomal localization of the YB-1 gene encoding a 42 kD nuclear CCAAT binding protein
    D D Spitkovsky
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Nucleic Acids Res 20:797-803. 1992
    ..Finally, we have identified four YB-1 related loci in the mouse genome and have mapped these loci to four different mouse chromosomes by interspecific backcross analysis...
  56. pmc Transforming growth factor-beta 3 is required for secondary palate fusion
    G Proetzel
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Nat Genet 11:409-14. 1995
    ..No craniofacial abnormalities were observed. This result demonstrates that TGF-beta 3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects...
  57. ncbi Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion
    H Matsunami
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Biol 172:466-78. 1995
    ..These results suggest that cadherins confer region-specific adhesiveness on fetal brain cells and that this process may take part in brain segmentation...
  58. ncbi Mouse embryonic submandibular gland epithelium loses its tissue integrity during early branching morphogenesis
    Y Hieda
    Department of Biology, Graduate School of Science, Osaka University, Japan
    Dev Dyn 207:395-403. 1996
    ....
  59. ncbi Cadherins and tissue formation: integrating adhesion and signaling
    K Vleminckx
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Bioessays 21:211-20. 1999
    ..We discuss how cadherins, through their effects on cell proliferation, cell death, cell polarization, and differentiation, play a role in the formation of tissues and organs in the developing embryo...
  60. ncbi Specific interference with gene function by double-stranded RNA in early mouse development
    F Wianny
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nat Cell Biol 2:70-5. 2000
    ..The phenotypes observed are the same as those reported for null mutants of the endogenous genes. These findings offer the opportunity to study development and gene regulation in normal and diseased cells...
  61. ncbi Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryos
    B Yuan
    Department of Pediatrics, Women s and Children s Hospital, USC School of Medicine, Los Angeles, California 90033, USA
    Dev Dyn 217:180-90. 2000
    ..1 independent, while distal lung morphogenesis appears to be strictly dependent on the wild-type activity of Nkx2.1...
  62. ncbi Dorsal pancreas agenesis in N-cadherin- deficient mice
    F Esni
    Department of Medical Biochemistry, Box 440, Goteborg University, Goteborg, S 405 30, Sweden
    Dev Biol 238:202-12. 2001
    ..Further analysis demonstrated that the mechanism for the lack of a dorsal pancreas involves an essential function of N-cadherin as a survival factor in the dorsal pancreatic mesenchyme...
  63. ncbi The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells
    Mutsumi Kanamori
    Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    J Biol Chem 278:38758-64. 2003
    ..These data suggest that TIP-1 may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway...
  64. pmc Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses
    Christopher L Tinkle
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:552-7. 2004
    ..These findings suggest that, if no compensatory mechanisms exist, E-cadherin loss may be incompatible with epithelial tissue survival, whereas partial compensation can result in alterations in differentiation and proliferation...
  65. ncbi Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas
    Farzad Esni
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Development 131:4213-24. 2004
    ..These results define a normal inhibitory role for Notch in the regulation of exocrine pancreatic differentiation...
  66. ncbi Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo
    Fay C Thomas
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    J Cell Sci 117:5599-608. 2004
    ....
  67. pmc E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
    Judith A Tunggal
    Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    EMBO J 24:1146-56. 2005
    ..Surprisingly, our results indicate that E-cadherin is specifically required for tight junction, but not desmosome, formation and this appears to involve signalling rather than cell contact formation...
  68. pmc Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype
    Vladimir N Simirskii
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Dev Biol 306:658-68. 2007
    ..Thus, beta1-integrin is required to maintain the lens epithelial phenotype and block inappropriate activation of some aspects of the lens fiber cell differentiation program...
  69. doi Integrin-linked kinase regulates E-cadherin expression through PARP-1
    Timothy R McPhee
    Genetics Graduate Program, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
    Dev Dyn 237:2737-47. 2008
    ..We suggest a model in which ILK represses E-cadherin expression by regulating PARP-1, leading to the binding of PARP-1 to SIRE and modulation of Snail expression...
  70. pmc Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues
    Y Shimoyama
    Pathology and Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    J Cell Biol 109:1787-94. 1989
    ..The results obtained in this study support the idea that P-cadherin plays little role, if any, in Ca2+-dependent cell-cell binding in human placental tissue at least after several weeks of pregnancy...
  71. ncbi Prox1 function is crucial for mouse lens-fibre elongation
    J T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Genet 21:318-22. 1999
    ..Our data provide evidence that the progression of terminal fibre differentiation and elongation is dependent on Prox1 activity during lens development...
  72. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
    ..Our data demonstrate that beta-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm...
  73. ncbi Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin
    Y Luo
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 128:459-69. 2001
    ....
  74. pmc The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition
    E A Carver
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Mol Cell Biol 21:8184-8. 2001
    ....
  75. ncbi Desmoplakin is essential in epidermal sheet formation
    V Vasioukhin
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Cell Biol 3:1076-85. 2001
    ..DP is therefore required for assembly of functional desmosomes, maintaining cytoskeletal architecture and reinforcing membrane attachments essential for stable intercellular adhesion...
  76. ncbi Beta-catenin is essential for pancreatic acinar but not islet development
    L Charles Murtaugh
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 132:4663-74. 2005
    ..Thus, our data are consistent with a crucial role for canonical Wnt signals in acinar lineage specification and differentiation...
  77. pmc Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice
    Gamze Kilic
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Dev Dyn 235:1659-67. 2006
    ..Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses...
  78. ncbi Retinoid signaling determines germ cell fate in mice
    Josephine Bowles
    Division of Genetics and Developmental Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Science 312:596-600. 2006
    ..Thus, precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate...
  79. pmc Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver
    Michele A Battle
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
    Proc Natl Acad Sci U S A 103:8419-24. 2006
    ..Although HNF4alpha-null hepatocytes do not express E-cadherin (also called CDH1), we show here that E-cadherin is dispensable for liver development, implying that HNF4alpha regulates additional ..
  80. pmc Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice
    Amir Asayesh
    Umeå Centre for Molecular Medicine, Umea University, S 901 87, Umea, Sweden
    Genes Dev 20:2208-13. 2006
    ....
  81. pmc The transcriptional repressor Glis2 is a novel binding partner for p120 catenin
    Catherine Rose Hosking
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Biology, University College London, London WC1E 6BT, UK
    Mol Biol Cell 18:1918-27. 2007
    ..These data indicate that p120 has additional novel functions in the nucleus together with Glis2...
  82. pmc Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells
    Tatsuya Katsuno
    Laboratory of Biological Science, Graduate School of Frontier Biosciences, and Graduate School of Medicine, Osaka University, Japan
    Mol Biol Cell 19:2465-75. 2008
    ..In conclusion, ZO-1 may be functionally important for cell remodeling and tissue organization in both the embryonic and extraembryonic regions, thus playing an essential role in embryonic development...
  83. pmc The branching programme of mouse lung development
    Ross J Metzger
    Department of Biochemistry and HHMI, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Nature 453:745-50. 2008
    ..We show that this hierarchical and modular programme is genetically tractable, and it is ideally suited to encoding and evolving the complex networks of the lung and other branched organs...
  84. pmc A nonneural epithelial domain of embryonic cranial neural folds gives rise to ectomesenchyme
    Marie Anne Breau
    Centre National de la Recherche Scientifique, Unite Mixte de Recherche 144, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Proc Natl Acad Sci U S A 105:7750-5. 2008
    ..We also show that ectomesenchymal cells exhibit beta-galactosidase activity in embryos heterozygous for an Ecad-lacZ reporter knock- in allele...
  85. pmc Endothelial-specific ablation of serum response factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality
    Mary L Holtz
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    BMC Dev Biol 8:65. 2008
    ..Resulting embryos were harvested at specific ages for observation of physical condition and analysis of genotype...
  86. pmc Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
    Nan Gao
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Genes Dev 22:3435-48. 2008
    ..Thus, the regulation of Pdx1 expression by Foxa1 and Foxa2 is a key early event controlling the expansion and differentiation of the pancreatic primordia...
  87. pmc Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells
    Guoping Zheng
    Centre for Transplantation and Renal Research, The University of Sydney at Westmead Millennium Institute, Westmead, NSW 2145 Australia
    Am J Pathol 175:580-91. 2009
    ..Specific inhibition rather than activation of matrix metalloproteinases may offer a novel approach for treatment of fibrotic disease...
  88. doi Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth
    Myriam Solar
    Genomic Programming of Beta Cells Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    Dev Cell 17:849-60. 2009
    ..Thus, once the ductal epithelium differentiates it has a restricted plasticity, even under regenerative settings...
  89. doi Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
    Hugo J Snippert
    Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Cell 143:134-44. 2010
    ..Quantitative analysis shows that stem cell turnover follows a pattern of neutral drift dynamics...
  90. pmc Localization of AQP5 during development of the mouse submandibular salivary gland
    Helga S Larsen
    Department of Oral Biology, Faculty of Dentistry, University of Oslo, Sognsvannsveien 10, Rikshospitalet, Blindern, Post Box 1052, 0316 Oslo, Norway
    J Mol Histol 42:71-81. 2011
    ..These results demonstrate an evolving distribution of AQP5 during pre- and postnatal development in the mouse SMGs...
  91. ncbi Cell-adhesion molecule uvomorulin during kidney development
    D Vestweber
    Dev Biol 112:213-21. 1985
    ..The 120-kDa glycoprotein, called uvomorulin, is known to be present on a number of epithelia...
  92. ncbi Expression and functional role of E- and P-cadherins in mouse mammary ductal morphogenesis and growth
    C W Daniel
    Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz 95064, USA
    Dev Biol 169:511-9. 1995
    ..These data indicate that spatially selective expression of E- and P-cadherins is required for mammary tissue integrity, which is in turn a prerequisite for normal rates of DNA synthesis...
  93. ncbi E-cadherin in the mature and developing organ of Corti of the mouse
    D S Whitlon
    Waisman Center, University of Wisconsin, Madison 53705
    J Neurocytol 22:1030-8. 1993
    ....
  94. ncbi Aberrant expression of Pax-2 in Danforth's short tail (Sd) mice
    D E Phelps
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    Dev Biol 157:251-8. 1993
    ..The Danforth's short tail mutation is a useful model for the study of developmentally regulated genes that are under the influence of the notochord or floor plate...
  95. ncbi Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 1. Follicle morphogenesis in wild-type mice
    M H Hardy
    Department of Biomedical Sciences, University of Guelph, Ont, Canada
    Acta Anat (Basel) 157:169-82. 1996
    ..The results suggest that the main role of cell adhesion molecules is to mould the follicle by relaxing or reinforcing cell contacts in areas of increased morphogenetic activity...
  96. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  97. ncbi Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors
    P J Miettinen
    Department of Pathology and Transplantation Laboratory, The Haartman Institute, and Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Development 127:2617-27. 2000
    ..Upregulated PAI-1 production and decreased gelatinolytic activity correlated to this migration defect. An intact EGF-R pathway appears to be a prerequisite for normal pancreatic development...
  98. ncbi The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover
    A H Huber
    Departments of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 276:12301-9. 2001
    ....
  99. ncbi Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
    Yasuyuki Fujita
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13125 Berlin, Germany
    Nat Cell Biol 4:222-31. 2002
    ..Through dynamic recycling of E-cadherin, Hakai can thus modulate cell adhesion, and could participate in the regulation of epithelial--mesenchymal transitions in development or metastasis...
  100. pmc A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
    Philippe Marambaud
    Department of Psychiatry and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    EMBO J 21:1948-56. 2002
    ..Thus, the PS1/gamma-secretase system stimulates disassembly of the E-cadherin- catenin complex and increases the cytosolic pool of beta-catenin, a key regulator of the Wnt signaling pathway...
  101. ncbi Functions of FGF signalling from the apical ectodermal ridge in limb development
    Xin Sun
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, 94143 0452, USA
    Nature 418:501-8. 2002
    ..In the complete absence of both FGF4 and FGF8 activities, limb development fails. We present a model to explain how the mutant phenotypes arise from FGF-mediated effects on limb bud size and cell survival...

Research Grants5

  1. The Role of MicroRNA in Hepatocarcinogenesis
    Kalpana Ghoshal; Fiscal Year: 2007
    ..Further, this proposal fits well with the mission/goals set forth by multiple institutes that include NCI, NIDDK and NIAAA n the etiology, prevention and treatment of hepatocellular carcinomas. [unreadable] [unreadable] [unreadable]..
  2. THE ROLE OF SRF IN CARDIAC FUNCTION AND DEVELOPMENT
    RAVINDRA MISRA; Fiscal Year: 2005
    ..These studies will both elucidate the mechanisms by which SRF functions in heart and will establish powerful new methodologies for studying heart formation and function. ..
  3. Transcription Factor P53 in Terminal Nephron Different
    Zubaida Saifudeen; Fiscal Year: 2004
    ..The results of this work will provide information on what determines terminal renal differentiation. In addition, these data will advance our understanding of the role the tumor suppressor p53 in kidney development...
  4. Investigating deskmoplakin during vasculogenesis
    G Gallicano; Fiscal Year: 2006
    ..The knowledge gained from this research will provide novel insights into vasculo- and angiogenesis during developmental and tumor growth and possibly provide novel approaches for inhibiting tumorigenesis. ..
  5. Transcriptional Control of Early Coronary Vascular Development
    RAVINDRA P MISRA; Fiscal Year: 2010
    ....