Cdc42

Summary

Gene Symbol: Cdc42
Description: cell division cycle 42
Alias: AI747189, AU018915, cell division control protein 42 homolog, G25K GTP-binding protein, cell division cycle 42 homolog
Species: mouse

Top Publications

  1. ncbi Rho GTPases and the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Science 279:509-14. 1998
  2. pmc A role for Cdc42 in macrophage chemotaxis
    W E Allen
    Muscle and Motility Research Centre, Randall Institute, King s College London WC2B 5RL, UK
    J Cell Biol 141:1147-57. 1998
  3. ncbi Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA
    S K Prakash
    Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 9:477-88. 2000
  4. ncbi Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes
    Isao Usui
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla 92093, USA
    J Biol Chem 278:13765-74. 2003
  5. ncbi Cdc42 and mDia3 regulate microtubule attachment to kinetochores
    Shingo Yasuda
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nature 428:767-71. 2004
  6. ncbi Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1
    Frédéric Causeret
    Institut Cochin, GDPM, INSERM U567, CNRS 8104, Universite Paris V, CHU Cochin, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Development 131:2841-52. 2004
  7. ncbi Activation of endogenous Cdc42 visualized in living cells
    Perihan Nalbant
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
    Science 305:1615-9. 2004
  8. ncbi Involvement of the phosphatidylinositol 3-kinase/rac1 and cdc42 pathways in radial migration of cortical neurons
    Daijiro Konno
    Department of Neuroscience D13, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 280:5082-8. 2005
  9. pmc Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin
    Hideki Yamaguchi
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 168:441-52. 2005
  10. ncbi Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes
    Akihiko Nishikimi
    Laboratory of Experimental Animal Model Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3, Gengo, Morioka cho, Obu City, Aichi 474 8522, Japan
    FEBS Lett 579:1039-46. 2005

Research Grants

Scientific Experts

Detail Information

Publications130 found, 100 shown here

  1. ncbi Rho GTPases and the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Science 279:509-14. 1998
    ....
  2. pmc A role for Cdc42 in macrophage chemotaxis
    W E Allen
    Muscle and Motility Research Centre, Randall Institute, King s College London WC2B 5RL, UK
    J Cell Biol 141:1147-57. 1998
    Three members of the Rho family, Cdc42, Rac, and Rho are known to regulate the organization of actin-based cytoskeletal structures. In Bac1...
  3. ncbi Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA
    S K Prakash
    Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 9:477-88. 2000
    ..These results suggest that ARHGAP6 has two independent functions: one as a GAP with specificity for RhoA and the other as a cytoskeletal protein that promotes actin remodeling...
  4. ncbi Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes
    Isao Usui
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla 92093, USA
    J Biol Chem 278:13765-74. 2003
    We investigated the role of cdc42, a Rho GTPase family member, in insulin-induced glucose transport in 3T3-L1 adipocytes...
  5. ncbi Cdc42 and mDia3 regulate microtubule attachment to kinetochores
    Shingo Yasuda
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nature 428:767-71. 2004
    ..We now show that one member of this family, Cdc42, and its effector, mDia3, regulate MT attachment to kinetochores.
  6. ncbi Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1
    Frédéric Causeret
    Institut Cochin, GDPM, INSERM U567, CNRS 8104, Universite Paris V, CHU Cochin, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Development 131:2841-52. 2004
    ..axon outgrowth of PCN and prevents nuclei migration toward a netrin 1 source, whereas inhibition of Rac and Cdc42 sub-families impair neurite outgrowth of PCN without affecting migration...
  7. ncbi Activation of endogenous Cdc42 visualized in living cells
    Perihan Nalbant
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
    Science 305:1615-9. 2004
    Signaling proteins are tightly regulated spatially and temporally to perform multiple functions. For Cdc42 and other guanosine triphosphatases, the subcellular location of activation is a critical determinant of cell behavior...
  8. ncbi Involvement of the phosphatidylinositol 3-kinase/rac1 and cdc42 pathways in radial migration of cortical neurons
    Daijiro Konno
    Department of Neuroscience D13, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 280:5082-8. 2005
    ..In the neocortical slice culture, a PI 3-kinase inhibitor suppressed the formation of GTP-bound Rac1 and Cdc42 and radial migration...
  9. pmc Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin
    Hideki Yamaguchi
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 168:441-52. 2005
    ..expression analyses revealed that neural WASP (N-WASP), Arp2/3 complex, and their upstream regulators, Nck1, Cdc42, and WIP, are necessary for invadopodium formation...
  10. ncbi Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes
    Akihiko Nishikimi
    Laboratory of Experimental Animal Model Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3, Gengo, Morioka cho, Obu City, Aichi 474 8522, Japan
    FEBS Lett 579:1039-46. 2005
    ..Zizimin2 and zizimin1 have similar primary structures and both proteins bound and activated Cdc42 but not the Cdc42-related proteins TC10 or TCL...
  11. ncbi Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic beta-cells
    Angela K Nevins
    Department of Biochemistry and Molecular Biology and Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 281:18961-72. 2006
    The cycling of the small Rho family GTPase Cdc42 is required for insulin granule exocytosis, although the regulatory proteins involved in Cdc42 cycling in pancreatic beta-cells are unknown...
  12. ncbi Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function
    Jie Na
    The Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, United Kingdom
    Curr Biol 16:1249-54. 2006
    ..Here, we show that Cdc42, a key regulator of cytoskeleton and cell polarity in other systems , is essential for meiotic maturation and ..
  13. pmc Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization
    Irina Tskvitaria-Fuller
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 177:1708-20. 2006
    ..The Rho family GTPase Cdc42 is a central regulator of cellular polarization...
  14. pmc Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
    Mol Biol Cell 17:4675-85. 2006
    Recent studies in Cdc42 knockout mouse embryonic stem (ES) cells and ES-derived fibroblastoid cell lines raise concern on a body of literature derived by dominant mutant expression approach in a variety of cell lines implicating ..
  15. ncbi Cdc42 is involved in PKCepsilon- and delta-induced neurite outgrowth and stress fibre dismantling
    Ulrika Trollér
    Lund University, Department of Laboratory Medicine, Molecular Medicine, Entrance 78, 3rd Floor, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 349:91-8. 2006
    ..This was accompanied by stress fibre loss. Here, we have examined the role of the small GTPases, Rac1, and Cdc42, in these PKC-mediated morphological and cytoskeletal changes...
  16. ncbi Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42
    Qiong Lin
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 281:35253-62. 2006
    b>Cdc42, a member of the Rho subfamily of small GTPases, influences a wide range of activities including the establishment of cell polarity, migration, and the regulation of cell growth and differentiation...
  17. ncbi Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS
    Tina Thurnherr
    Institute for Cell Biology, Department of Biology, Federal Institute of Technology ETH Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 26:10110-9. 2006
    ..Ablation of Cdc42 in cells of the oligodendrocyte lineage did not affect OPC proliferation, directed migration, or in vitro ..
  18. pmc A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis
    Zaira García
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    EMBO J 25:4740-51. 2006
    ..We analyzed the mechanism by which p85alpha regulates cytokinesis; p85alpha deletion reduced Cdc42 activation in the cleavage furrow and septin 2 accumulation at this site...
  19. pmc Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly
    Lei Chen
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 103:16520-5. 2006
    ..pathway that establishes this apical-basal polarity of NE is not completely understood, but the Rho-family GTPase Cdc42 may play a critical role because it controls cadherin-based intercellular junctions and cell polarity in many ..
  20. ncbi Cdc42 is implicated in polarity during meiotic resumption and blastocyst formation in the mouse
    Xiang Shun Cui
    National Research Laboratory of Molecular Embryology, Department of Animal Sciences, Chungbuk National University, Seoul, Korea
    Mol Reprod Dev 74:785-94. 2007
    Cell division cycle 42 (Cdc42), a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including: motility, proliferation, apoptosis, and cell morphology...
  21. pmc Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion
    Zhanxiang Wang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 282:9536-46. 2007
    The small Rho family GTPases Cdc42 and Rac1 have each been shown to function in insulin exocytosis and are presumed to function in actin remodeling and insulin granule mobilization...
  22. pmc Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow
    Linda Yang
    Division of Experimental Hematology and Pathology, Cincinnati Children s Research Foundation, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 104:5091-6. 2007
    ..In a conditional-knockout mouse model, we show that Cdc42(-/-) HSCs enter the active cell cycle, resulting in significantly increased number and frequency of the stem/..
  23. ncbi MicroRNA-133 controls cardiac hypertrophy
    Alessandra Carè
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, 00161 Rome, Italy
    Nat Med 13:613-8. 2007
    ..We identified specific targets of miR-133: RhoA, a GDP-GTP exchange protein regulating cardiac hypertrophy; Cdc42, a signal transduction kinase implicated in hypertrophy; and Nelf-A/WHSC2, a nuclear factor involved in ..
  24. pmc Developmental expression of three small GTPases in the mouse eye
    Dianne C Mitchell
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX, USA
    Mol Vis 13:1144-53. 2007
    ..To explore this possibility, we examined the expression patterns of three major Rho-GTPases: RhoA, Rac1, and Cdc42 in embryonic, postnatal (one day after birth), and adult (two-month old) mouse eye.
  25. pmc Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways
    Tanja Bosse
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research HZI, Inhoffenstrasse 7, D 38124, Braunschweig, Germany
    Mol Cell Biol 27:6615-28. 2007
    ..c-Met ligand internalin B (InlB) were significantly impaired but not abrogated upon genetic removal of either Cdc42 or pharmacological inhibition of phosphoinositide 3-kinase (PI3-kinase)...
  26. pmc Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 110:3853-61. 2007
    The Rho GTPase Cdc42 regulates adhesion, migration, and homing, as well as cell cycle progression, of hematopoietic stem cells, but its role in multilineage blood development remains unclear...
  27. pmc Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC
    Scott X Atwood
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
    J Cell Sci 120:3200-6. 2007
    b>Cdc42 recruits Par-6-aPKC to establish cell polarity from worms to mammals...
  28. ncbi Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development
    Xunwei Wu
    University of Copenhagen, Institute of Molecular Pathology, Copenhagen, Denmark
    Dev Dyn 236:2767-78. 2007
    To study the role of Cdc42 in the establishment of epithelial polarity during mammalian development, we generated murine Cdc42-null embryonic stem cells and analyzed peri-implantation development using embryoid bodies (EBs)...
  29. ncbi Cdc42 regulates cofilin during the establishment of neuronal polarity
    Boyan K Garvalov
    Axonal Growth and Regeneration Group, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    J Neurosci 27:13117-29. 2007
    ..We analyzed the consequences of loss of Cdc42, a central regulator of polarity in multiple systems, on the polarization of mammalian neurons...
  30. doi Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver
    Jolanda van Hengel
    Molecular Cell Biology Unit, VIB, Ghent, Belgium Department of Molecular Biology, Ghent University, Ghent, Belgium
    Gastroenterology 134:781-92. 2008
    The Rho small guanosine triphosphatase Cdc42 is critical for diverse cellular functions, including regulation of actin organization, cell polarity, intracellular membrane trafficking, transcription, cell-cycle progression, and cell ..
  31. doi Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins
    C Schnack
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Biberach an der Riss, Germany
    Neuroscience 154:1450-7. 2008
    ..with recombinant alpha-synuclein oligomers lead to the identification of several GTPase activating proteins and Cdc42 effector proteins as binding partners...
  32. doi Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos
    Anna Bielak-Zmijewska
    Department of Embryology, Institute of Zoology, University of Warsaw, Miecznikowa 1, 02 096 Warsaw, Poland
    Dev Biol 322:21-32. 2008
    b>Cdc42 and Rac1 Rho family GTPases, and their interacting protein IQGAP1 are the key regulators of cell polarity...
  33. pmc FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles
    Christoph Huber
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 283:34002-12. 2008
    ..family encode a group of critical guanine nucleotide exchange factors (GEFs), which, by specifically activating Cdc42, control cytoskeleton-dependent membrane rearrangements...
  34. doi Essential role of Rac1 and Rac3 GTPases in neuronal development
    Sara Corbetta
    Cell Adhesion Unit, San Raffaele Scientific Institute and University Vita Salute San Raffaele, Via Olgettina 58 20132 Milano, Italy
    FASEB J 23:1347-57. 2009
    ..These findings show for the first time that both Rac1 and Rac3 are important for the development of the nervous system, wherein they play complementary roles during late stages of neuronal and brain development...
  35. doi Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration
    Tim Lämmermann
    Hofschneider Group Leukocyte Migration, Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    Blood 113:5703-10. 2009
    ..We here delete the small GTPase Cdc42 in DCs and find that actin flow and actomyosin contraction are still initiated in response to chemotactic cues...
  36. pmc Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system
    Jorge A Pereira
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland
    J Cell Biol 185:147-61. 2009
    ..ILK also facilitates axon remyelination, likely by promoting the activation of downstream molecules such as AKT/protein kinase B...
  37. doi Cadherin-cadherin engagement promotes cell survival via Rac1/Cdc42 and signal transducer and activator of transcription-3
    Rozanne Arulanandam
    Department of Microbiology and Immunology, Department of Pathology and Molecular Medicine, and Cancer Research Institute, Queen s University, Ontario, Canada K7L 3N6
    Mol Cancer Res 7:1310-27. 2009
    ..Most importantly, our results also reveal for the first time an unexpected and dramatic surge in total Rac1 and Cdc42 protein levels triggered by cadherin engagement and an increase in Rac1 and Cdc42 activity, which is responsible ..
  38. pmc Rho GTPase Cdc42 is essential for B-lymphocyte development and activation
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, OH 45229, USA
    Blood 114:2909-16. 2009
    b>Cdc42 is a member of the Rho GTPase family that has been implicated in several cell functions including proliferation and migration, but its physiologic role needs to be dissected in each cell type...
  39. pmc Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP
    Haein Park
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Mol Biol Cell 20:4500-8. 2009
    b>Cdc42 is a key regulator of the actin cytoskeleton and activator of Wiskott-Aldrich syndrome protein (WASP)...
  40. pmc Cdc42 is an antihypertrophic molecular switch in the mouse heart
    Marjorie Maillet
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, University of Cincinnati, and Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Clin Invest 119:3079-88. 2009
    ..Here we identify the small GTPase Cdc42 as a signaling intermediate that restrained the cardiac growth response to physiologic and pathologic stimuli...
  41. pmc The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling
    Kathleen Szczur
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Blood 114:4527-37. 2009
    ..Using a mouse model of high Cdc42 activity, we previously demonstrated the importance of Cdc42 activity in neutrophil migration...
  42. pmc Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination
    Bharesh K Chauhan
    The Visual Systems Group, Children s Hospital Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 136:3657-67. 2009
    ..Formation of filopodia is dependent on the Rho family GTPase Cdc42 and the Cdc42 effector IRSp53 (Baiap2). Loss of filopodia results in reduced lens pit invagination...
  43. pmc A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis
    Peter Beemiller
    Cellular and Molecular Biology Graduate Program, and Biophysics Graduate Program, University of Michigan, Ann Arbor, MI, USA
    Mol Biol Cell 21:470-80. 2010
    ..phagocytosis by macrophages requires phosphatidylinositol 3-kinase (PI3K) and activation of the Rho-family GTPases Cdc42 and Rac1...
  44. doi Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets
    Irina Pleines
    Department of Vascular Medicine, University Clinic, University of Würzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Wurzburg, Germany
    Blood 115:3364-73. 2010
    ..Cytoskeletal reorganization is essential for platelet activation and secretion. The small GTPase Cdc42 has been implicated as an important mediator of filopodia formation and exocytosis in various cell types, but its ..
  45. pmc Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:18505-10. 2010
    ..Here we demonstrate that T cell-specific deletion of cell-division cycle 42 (Cdc42) GTPase causes a profound loss of mature T cells...
  46. pmc Cdc42 and Gsk3 modulate the dynamics of radial glial growth, inter-radial glial interactions and polarity in the developing cerebral cortex
    Yukako Yokota
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Development 137:4101-10. 2010
    ..Polarized expression of the cell polarity regulator Cdc42 in radial glia regulates glial endfeet activities and inter-radial glial interactions...
  47. pmc Signaling role of Cdc42 in regulating mammalian physiology
    Jaime Melendez
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:2375-81. 2011
    b>Cdc42 is a member of the Rho GTPase family of intracellular molecular switches regulating multiple signaling pathways involved in actomyosin organization and cell proliferation...
  48. pmc Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors
    S R Heynen
    Laboratory for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Switzerland
    Mol Vis 17:2934-46. 2011
    Rho GTPases such as RAS-related C3 botulinum substrate 1 (RAC1) and cell division cycle 42 homolog (S. cerevisiae; CDC42) have been linked to cellular processes including movement, development, and apoptosis...
  49. doi Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development
    Ryo Aizawa
    Department of Biochemistry, School of Dentistry, Showa University, Shinagawa ku, Tokyo 142 8555, Japan
    Mech Dev 129:38-50. 2012
    b>Cdc42, a member of the Rho subfamily of small GTPases, is known to be a regulator of multiple cellular functions, including cytoskeletal organization, cell migration, proliferation, and apoptosis...
  50. pmc Podocyte-specific loss of Cdc42 leads to congenital nephropathy
    Rizaldy P Scott
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Am Soc Nephrol 23:1149-54. 2012
    ..The prototypic members of this family are Cdc42, Rac1, and RhoA; these GTPases contribute to the breakdown of glomerular filtration and the resultant proteinuria, ..
  51. pmc Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation
    Maria Carolina Florian
    Department of Dermatology and Allergic Diseases, University of Ulm, 89091 Ulm, Germany
    Cell Stem Cell 10:520-30. 2012
    ..Here we demonstrate that elevated activity of the small RhoGTPase Cdc42 in aged HSCs is causally linked to HSC aging and correlates with a loss of polarity in aged HSCs...
  52. pmc Cooperative activation of PI3K by Ras and Rho family small GTPases
    Hee Won Yang
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    Mol Cell 47:281-90. 2012
    ..small GTPases activated PI3K by an indirect cooperative positive feedback that required a combination of Rac, CDC42, and RhoG small GTPase activities...
  53. pmc PtdIns(3,4,5)P3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes
    Ping Zheng
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
    J Cell Sci 126:715-21. 2013
    ..F-actin nucleator Fmn2 and Rho GTPase Cdc42 play roles in mediating the effect of PtdIns(3,4,5)P3 on F-actin assembly...
  54. pmc Polarized Cdc42 activation promotes polar body protrusion and asymmetric division in mouse oocytes
    Benoit Dehapiot
    CNRS, UMR 6290, Institut de Génétique et Développement de Rennes, F 35043 Rennes, France
    Dev Biol 377:202-12. 2013
    ..b>Cdc42 is a major player in cell polarization in many systems; however, the spatio-temporal dynamics of Cdc42 activation ..
  55. pmc Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development
    Yves Benninger
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 177:1051-61. 2007
    ..We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells...
  56. ncbi Trio controls the mature organization of neuronal clusters in the hindbrain
    Stéphanie Backer
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104, 75014 Paris, France
    J Neurosci 27:10323-32. 2007
    ..Altogether, those results establish a link between Trio activity, the subsequent Rac1 activation, and neuronal clusters organization, as well as a possible recruitment of the Cadherin-11 adhesive receptor to form a complex with Trio...
  57. ncbi Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation
    Lei Wei
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Development 129:1705-14. 2002
    ..0 during morphogenesis of the linear heart tube. RhoA, Rac1 and Cdc42 activities were significantly inhibited, as shown by decreased membrane translocation of these proteins in the ..
  58. ncbi CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities
    Yoshiki Yanagawa
    Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Blood 101:4923-9. 2003
    ..blocked by Clostridium difficile toxin B, which inhibits the Rho guanosine triphosphatase proteins, Rho, Rac, and Cdc42. This process was not abrogated by Y-27632, a specific inhibitor of Rho-associated kinase...
  59. pmc Coordination of Rho GTPase activities during cell protrusion
    Matthias Machacek
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Nature 461:99-103. 2009
    The GTPases Rac1, RhoA and Cdc42 act together to control cytoskeleton dynamics...
  60. pmc Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development
    Yong Ri Jin
    COBRE in Stem Cell and Regenerative Medicine, Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME 04074, USA
    Development 139:1821-30. 2012
    ..Our study has identified a previously unknown regulatory link between WNT9B and FGF signaling during lip and upper jaw development...
  61. pmc Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers
    Ching Yan Chloé Yeung
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester, United Kingdom
    PLoS ONE 9:e107036. 2014
    ..Together, these data suggest that the regulation of Rho by RhoGAPs, including Arhgap28, during the assembly and development of mechanically strong tissues is complex and may involve multiple RhoGAPs. ..
  62. ncbi Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells
    Y Shiraishi
    Department of Molecular Neurobiology, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Neurosci 19:8389-400. 1999
    ..On the other hand, the C-terminal portion of Cupidin bound to Cdc42, a member of Rho family small GTPases, in a GTP-dependent manner in vitro, and Cupidin functionally interacted ..
  63. pmc MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity
    Carolina Montenegro-Venegas
    Department of Biology, Universidad de Chile, Santiago, Chile
    Mol Biol Cell 21:3518-28. 2010
    ..Here we show that MAP1B deficiency results in a significant decrease in Rac1 and cdc42 activity and a significant increase in Rho activity...
  64. pmc ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
    Karina Haebig
    Department of Medical Genetics, Institute of Human Genetics, University of Tuebingen, Tuebingen, Germany
    PLoS ONE 5:e13762. 2010
    ..Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro...
  65. pmc Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice
    Lara Rossi
    Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Stem Cell 11:302-17. 2012
    ..Finally, we propose recommendations for characterization of HSC function in knockout mice to facilitate cross-study comparisons that would generate a more cohesive picture of HSC biology...
  66. pmc RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration
    Kei Ichi Katayama
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Development 140:3139-45. 2013
    ..Although RhoA and Cdc42, members of the Rho family of small GTPases, have been implicated in regulating neuronal migration, their ..
  67. ncbi The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach
    P Chavrier
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, F R G
    Gene 112:261-4. 1992
    ..These results confirm that the overall diversity of the Rab and Rho protein subfamilies account for more than thirty different members in mammalian cells...
  68. ncbi Complete cDNAs for CDC42 from chicken cochlea and mouse liver
    T W Gong
    Kresge Hearing Research Institute, Department of Otolaryngology Head Neck Surgery, Ann Arbor, MI 48109 0648, USA
    Biochim Biophys Acta 1352:282-92. 1997
    b>CDC42 is a member of the ras superfamily of small GTP-binding proteins that are related through the highly conserved GTP-binding domain and are involved in signal transduction pathways...
  69. ncbi The mouse Rhl1 and Rhag genes: sequence, organization, expression, and chromosomal mapping
    Z Liu
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    Biochem Genet 37:119-38. 1999
    ..The results together predate the occurrence and signify a conserved function of the erythroid-specific Rh membrane structures...
  70. ncbi Molecular cloning and sequencing of rat Cdc42 GTPase cDNA
    J S Han
    Institute of Biomedical Science and Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea
    Exp Mol Med 32:115-9. 2000
    b>Cdc42 is a member of the Rho family of small GTP-ase and plays an important role in intracellular signaling pathways regulating cell morphology, motility and stimulation of DNA synthesis...
  71. pmc Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein
    X R Ren
    Department of Pathology and Cell Adhesion and Matrix Center, Pathology, and Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Cell Biol 152:971-84. 2001
    ..PSGAP is able to increase GTPase activity of CDC42 and RhoA in vitro and in vivo...
  72. pmc Regulation of Cdc42-mediated morphological effects: a novel function for p53
    Gilles Gadea
    Centre de Recherche en Biochimie Macromoleculaire, CNRS UPR1086, IFR 24, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
    EMBO J 21:2373-82. 2002
    ..We investigated the overall effect of p53 on morphological changes induced by RhoA, Rac1 and Cdc42 GTPases in mouse embryonic fibroblasts (MEFs)...
  73. pmc N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts
    Sophie Charrasse
    Centre de Recherche de Biochimie Macromoleculaire, 34293 Montpellier Cedex, France
    J Cell Biol 158:953-65. 2002
    ..We propose that cell-cell contacts formed via N-cadherin trigger signaling events that promote the commitment to myogenesis through the positive regulation of RhoA and negative regulation of Rac1, Cdc42Hs, and JNK activities...
  74. ncbi Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Biol Chem 278:16189-97. 2003
    ..Mechanistically, ethanol stimulation activated Cdc42 and produced H(2)O(2) a reactive oxygen species intermediate in SVEC4-10 cells...
  75. ncbi Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development
    David R Natale
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Mech Dev 119:S21-6. 2002
    ..E-cadherin-based cell-to-cell adhesion through interactions with beta-catenin and the Rho GTPases, rac1 and cdc42. Our study demonstrates IQGAP-1,-2, rac-1 and cdc42 mRNAs are present throughout murine preimplantation ..
  76. pmc Vav GEFs are required for beta2 integrin-dependent functions of neutrophils
    M Angelica Martinez Gakidis
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Cell Biol 166:273-82. 2004
    ..Thus, Vav proteins are specifically required for stable adhesion. beta2-induced activation of Cdc42, Rac1, and RhoA is defective in Vav1/3ko neutrophils, and phosphorylation of Pyk2, paxillin, and Akt is also ..
  77. ncbi A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis
    Angela K Nevins
    Department of Biochemistry and Molecular Biology and the Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:1944-52. 2005
    ..SNAP) receptor) proteins, and this is coupled to cortical F-actin reorganization via the Rho family GTPase Cdc42 by an unknown mechanism...
  78. ncbi BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain
    Yi Ting Zhou
    Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, The National University of Singapore, Singapore 117543
    Exp Cell Res 303:263-74. 2005
    The Cdc42 small GTPase regulates cytoskeletal reorganization and cell morphological changes that result in cellular extensions, migration, or cytokinesis...
  79. pmc E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
    Judith A Tunggal
    Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    EMBO J 24:1146-56. 2005
    ..Surprisingly, our results indicate that E-cadherin is specifically required for tight junction, but not desmosome, formation and this appears to involve signalling rather than cell contact formation...
  80. ncbi Leishmania donovani promastigotes induce periphagosomal F-actin accumulation through retention of the GTPase Cdc42
    Robert Lodge
    INRS Institut Armand Frappier, 531, boul des Prairies, Laval, Quebec, Canada H7V 1B7
    Cell Microbiol 7:1647-58. 2005
    ..In this study, we addressed the role of the Rho-family GTPases RhoA, Rac1 and Cdc42 in the uptake of L. donovani promastigotes and in the accumulation of periphagosomal F-actin...
  81. ncbi c-Jun kinase mediates expression of VEGF induced at transcriptional level by Rac1 and Cdc42Hs but not by RhoA
    M Luisa Saníger
    Departamento de Biologia Experimental, Universidad de Jaen, Campus de las Lagunillas s n, 23071 Jaen, Spain
    J Cell Biochem 98:650-60. 2006
    ..We carried out transient and stable transfection with constitutively activated rhoA, rac1, and cdc42 mutants in COS-7 and NIH3T3 cells, respectively in the absence of external stimuli...
  82. ncbi The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor
    Song Xiang
    Department of Biochemistry, SUNY Stony Brook, NY 11794 5215, USA
    J Mol Biol 359:35-46. 2006
    ..to the Dbl family of guanine nucleotide exchange factors, occurs in multiple splice variants, and is specific for Cdc42, a small GTPase belonging to the Rho family. The 2...
  83. ncbi JNK phosphorylation of paxillin, acting through the Rac1 and Cdc42 signaling cascade, mediates neurite extension in N1E-115 cells
    Junji Yamauchi
    Department of Pharmacology, National Research Institute for Child Health and Development, 2 10 1 Oukura, Setagaya, Tokyo 157 8535, Japan
    Exp Cell Res 312:2954-61. 2006
    ..Here we show that c-Jun N-terminal kinase (JNK), which is controlled by Rho GTPases Rac1 and Cdc42, is activated following neurite extension in mouse N1E-115 neuroblastoma cells as a model...
  84. ncbi CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase
    Bin Wei
    Molecular Immunology Section, Department of Immunology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    J Immunol 179:400-8. 2007
    ..Polarization required PI3K, the guanine nucleotide exchange factor Vav1, the GTP-binding protein Cdc42, as well as myosin L chain kinase...
  85. pmc Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation
    Dejan M Nikolic
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 282:33405-11. 2007
    ..Because of their role in regulating actin polymerization and cell adhesion, Rac and Cdc42 activation were also examined and shown to be increased via an iPLA(2)- and LOX-dependent pathway...
  86. doi Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells
    Yidong Shen
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Dev Cell 14:342-53. 2008
    Cdc42GAP promotes inactivation of Cdc42, a small GTPase whose activation at the leading edge by guanine nucleotide exchange factors is critical for cell migration...
  87. pmc PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex
    Tsutomu Nakamura
    Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    Genes Dev 22:1244-56. 2008
    ..Here we show that PX-RICS, a beta-catenin-interacting GTPase-activating protein (GAP) for Cdc42, mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex...
  88. pmc Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture
    Yongjuan Chen
    Save Sight Institute, The University of Sydney, NSW 2001, Sydney, Australia
    Dev Biol 324:161-76. 2008
    ..Components of the Wnt/Planar Cell Polarity (PCP) pathway were downregulated or inhibited. Taken together this supports a role for Wnt/PCP signaling in orchestrating the complex organization and dynamics of the fiber cell cytoskeleton...
  89. pmc The bacterial virulence factor lymphostatin compromises intestinal epithelial barrier function by modulating rho GTPases
    Brian A Babbin
    Department of Pathology and Laboratory Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    Am J Pathol 174:1347-57. 2009
    ..rodentium wild type differentially influenced Rho GTPase activation, suppressed Cdc42 activation, and induced Rho GTPase activation...
  90. doi Rab35 regulates neurite outgrowth and cell shape
    Julien Chevallier
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    FEBS Lett 583:1096-101. 2009
    ..Here, we find that Rab35 colocalizes with actin filaments and with Cdc42, Rac1 and RhoA, and that Rab35 can activate Cdc42 both in vivo and in vitro...
  91. pmc Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications
    Xiao Sheng Jiang
    Section on Molecular Dysmorphology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1347-57. 2010
    ..Phosphorylation of cofilin-1 is regulated by Rho GTPases through Rho-Rock-Limk-Cofilin-1 and Rac/Cdc42-Pak-Limk-Cofilin-1 pathways...
  92. pmc Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42
    Parisa Sinai
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:11912-7. 2010
    ..Polarization was regulated by Cdc42, a small Rho family GTPase universally critical for cytoskeletal dynamics...
  93. pmc HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42
    Emhonta Johnson
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 285:29491-501. 2010
    ..ErbB2 induction of migration requires activation of the small GTPases Rac1 and Cdc42. The ability of ErbB2 to activate these small GTPases necessitated expression of p120 catenin, which is itself up-..
  94. pmc Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation
    Jost Leemhuis
    Center for Neuroscience, Albert Ludwigs University, 79104 Freiburg, Germany
    J Neurosci 30:14759-72. 2010
    ..Reelin activates the Rho GTPase Cdc42, known for its role in neuronal morphogenesis and directed migration, in an apolipoprotein E receptor 2-, Disabled-..
  95. pmc Two novel human NUMB isoforms provide a potential link between development and cancer
    Aldona Karaczyn
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Neural Dev 5:31. 2010
    ..Immunocytochemistry analyses show that NUMB5 and NUMB6 interact and complex with CDC42, vimentin and the CDC42 regulator IQGAP1 (IQ (motif) GTPase activating protein 1)...
  96. pmc RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac
    Minzhou Huang
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    J Cell Biochem 112:1572-84. 2011
    ..In this study, we show that RhoB is essential for activation and trafficking of the key migratory effectors Cdc42 and Rac in mediating the ability of platelet-derived growth factor (PDGF) to stimulate cell movement...
  97. pmc Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e18002. 2011
    b>Cdc42 of the Rho GTPase family has been implicated in cell actin organization, proliferation, survival, and migration but its physiological role is likely cell-type specific...
  98. pmc Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis
    Elma Aflaki
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Austria
    Cell Mol Life Sci 68:3933-47. 2011
    ..organization of the actin cytoskeleton, which is regulated by members of the small Rho GTPase family (RhoA, Cdc42, Rac) that are also important for the regulation of signal transduction pathways...
  99. doi Rho GTPases in hematopoietic stem/progenitor cell migration
    Wei Liu
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Methods Mol Biol 750:307-19. 2011
    Rho GTPases including RhoA, Rac1, and Cdc42 are a class of intracellular signaling proteins critical for the regulation of cytoskeleton organization, adhesion, and migration...
  100. pmc Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis
    Yanmei Qi
    Department of Surgery, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, 08903 0019, USA
    Arterioscler Thromb Vasc Biol 31:1861-70. 2011
    The goal of this study was to determine the role of Cdc42 in embryonic vasculogenesis and the underlying mechanisms.
  101. pmc The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner
    Chang Xie
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 286:35933-42. 2011
    ..Here, we find that GTP-bound Cdc42 interacts with NPC1L1...

Research Grants1

  1. TRE17 links actin remodeling & vesicle trafficking
    Margaret Chou; Fiscal Year: 2009
    Acquisition of a motile, invasive phenotype is a key step in malignant transformation. The Rho family GTPases Cdc42 and Rac1 play a central role in this process by regulating dynamic actin remodeling and vesicular trafficking, ..