Genomes and Genes
Gene Symbol: CD8
Description: CD8 antigen, alpha chain
Alias: BB154331, Ly-2, Ly-35, Ly-B, Lyt-2, T-cell surface glycoprotein CD8 alpha chain, Lyt-2.1 lymphocyte differentiation antigen (AA at 100), T-cell surface glycoprotein Lyt-2
Publications130 found, 100 shown here
- PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cellsA Guerriero
Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, PA 19104 6140, USA
Blood 95:879-85. 2000..PU. 1(-/-)lymphoid DC were functionally equivalent to WT DC for stimulating T-cell proliferation in mixed lymphocyte reactions. These results demonstrate that PU.1 is required for the development of myeloid DC but not lymphoid DC...
- Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivoJunko Matsuzaki
Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, 060 0815, Hokkaido, Sapporo, Japan
Cell Immunol 224:98-105. 2003..of Gr-1 antigen on various subsets of mouse spleen cells, we found that Gr-1 was expressed on memory-type CD8(+)CD44(high)CD62L(high) T cells in addition to granulocytes...
- Inhibiting galectin-1 reduces murine lung metastasis with increased CD4(+) and CD8 (+) T cells and reduced cancer cell adherenceKoichi Ito
School of Medical Science, Griffith Health Institute, Griffith University, Gold Coast Campus, Southport, QLD, 4222, Australia
Clin Exp Metastasis 29:561-72. 2012..Increased numbers of CD4(+) helper T cells and CD8(+) cytotoxic T lymphocytes were found in the peripheral blood of both TDG-treated and G1KD cell challenged mice...
- The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytesJ M Penninger
Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
Immunity 7:243-54. 1997..and transcriptional regulation that govern T cell selection processes and the differentiation of CD4+ and CD8+ T cells...
- SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoproteinT Inukai
Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Mol Cell 4:343-52. 1999....
- Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domainShin ichiro Takayanagi
Laboratory of Stem Cell Therapy, Center for Experimental Medicine, University of Tokyo, Japan
Blood 107:4317-25. 2006....
- CD8+ T cells but not polymorphonuclear leukocytes are required to limit chronic oral carriage of Candida albicans in transgenic mice expressing human immunodeficiency virus type 1Miriam Marquis
Department of Microbiology and Immunology, Sainte Justine Hospital and University of Montreal, 3175 Cote Ste Catherine, Montreal, Quebec H3T 1C5, Canada
Infect Immun 74:2382-91. 2006..of OPC in CD4C/HIV(Mut) transgenic (Tg) mice to investigate the role of polymorphonuclear leukocytes (PMNs) and CD8+ T cells in limiting candidiasis to the mucosa...
- CD8(+) T cells are not necessary for 1 alpha,25-dihydroxyvitamin D(3) to suppress experimental autoimmune encephalomyelitis in miceTerrence F Meehan
Department of Biochemistry, University of Wisconsin, College of Agricultural and Life Sciences, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 99:5557-60. 2002..The vitamin D receptor is believed to mediate this activity. Among cells of the immune system, CD8(+) T cells have the highest levels of the vitamin D receptor...
- FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infectionTimothy J Wilson
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
Blood 109:3786-93. 2007..FcRL6, that is expressed by cytolytic cells including natural killer (NK) cells and effector and effector-memory CD8(+) T cells...
- TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma productionRomina S Goldszmid
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Exp Med 204:2591-602. 2007To investigate if transporter associated with antigen processing (TAP)-1 is required for CD8(+) T cell-mediated control of Toxoplasma gondii in vivo, we compared the resistance of TAP-1(-/-), CD8(-/-), and wild-type (WT) mice to ..
- CD8 is needed for development of cytotoxic T cells but not helper T cellsW P Fung-Leung
Ontario Cancer Institute, University of Toronto, Canada
Cell 65:443-9. 1991A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell technology...
- Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expressionS D Gorman
Department of Medicine, Stanford University Medical Center, CA 94305
J Immunol 140:3646-53. 1988..L cells results in cell surface expression of Ly-3 protein only in the presence of Ly-2 (or its human homolog, CD8), although Ly-2 surface expression is not similarly dependent on Ly-3...
- A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic miceA Hostert
Laboratory of Molecular Immunology, National Institute for Medical Research, London, United Kingdom
J Immunol 158:4270-81. 1997Helper and cytotoxic T cell subsets require the expression of different coreceptors (CD4 and CD8, respectively) for their development and function...
- Differential requirements for survival and proliferation of CD8 naïve or memory T cellsC Tanchot
INSERM U345, Institut Necker, 156 rue Vaugirard, 75015 Paris, France
Science 276:2057-62. 1997The requisite molecular interactions for CD8 T cell memory were determined by comparison of monoclonal naïve and memory CD8(+) T cells bearing the T cell receptor (TCR) for the HY antigen...
- Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cellsA Hostert
Division of Molecular Immunology, National Institute for Medical Research, London, United Kingdom
Immunity 9:497-508. 1998CD4 and CD8 are crucial for the development and function of T cells. An intergenic deoxyribonuclease I hypersensitive site region (cluster CIII) directs expression in mature CD8 T cells only...
- Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2KbP S Kern
Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Immunity 9:519-30. 1998..In both species, coreceptor function apparently involves the participation of CD8 dimer in a bidentate attachment to an MHC class I molecule in conjunction with a T cell receptor without ..
- Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient miceM K Kennedy
Immunex Corporation, Seattle, Washington 98101, USA
J Exp Med 191:771-80. 2000..mice displayed marked reductions in numbers of thymic and peripheral natural killer (NK) T cells, memory phenotype CD8(+) T cells, and distinct subpopulations of intestinal intraepithelial lymphocytes (IELs)...
- Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymusR Bosselut
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Immunity 12:409-18. 2000The contribution of the CD8beta subunit to CD8 coreceptor function is poorly understood...
- Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytesR Bosselut
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 14:483-94. 2001The present study has assessed the impact of the intracellular domains of CD4 and CD8 on positive selection and lineage direction of MHC class I-restricted thymocytes...
- T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TLA J Leishman
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
Science 294:1936-9. 2001..These findings define a novel mechanism of lymphocyte regulation through CD8alphaalpha and MHC class I...
- Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expressionWilfried Ellmeier
Institute of Immunology, University of Vienna, Vienna, Austria
Immunity 16:623-34. 2002Developmental stage-, subset-, and lineage-specific CD8 enhancers have been identified recently by transgenic reporter analyses...
- Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequencesAnna Garefalaki
National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
Immunity 16:635-47. 2002The developmental and subset-specific expression of the CD8 genes is under the control of a complex array of regulatory elements distributed along the locus and characterized by DNaseI hypersensitivity...
- Effector CD8+ T cells mediate inflammation and airway hyper-responsivenessNobuaki Miyahara
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
Nat Med 10:865-9. 2004..Using a mouse model of allergen-induced AHR, we previously demonstrated that CD8-deficient mice develop significantly lower AHR, eosinophilic inflammation and interleukin (IL)-13 levels in ..
- Peripheral "CD8 tuning" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivoRobert Maile
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill 27599, USA
J Immunol 174:619-27. 2005In this study, we suggest that CD8 levels on T cells are not static, but can change and, as a result, modulate CD8(+) T cell responses...
- Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte developmentNicholas Feik
Institute of Immunology, Medical University Vienna, Vienna, Austria
J Immunol 174:1513-24. 2005Several developmental stage-, subset-, and lineage-specific Cd8 cis-regulatory regions have been identified...
- Progressive differentiation and commitment of CD8+ T cells to a poorly cytolytic CD8low phenotype in the presence of IL-4Norbert Kienzle
Cooperative Research Centre for Vaccine Technology and Queensland Institute of Medical Research, Brisbane, Queensland, Australia
J Immunol 174:2021-9. 2005Exposure to IL-4 during activation of naive murine CD8+ T cells leads to generation of IL-4-producing effector cells with reduced surface CD8, low perforin, granzyme B and granzyme C mRNA, and poor cytolytic function...
- The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitmentXiao He
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
Nature 433:826-33. 2005Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, ..
- Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsivenessNobuaki Miyahara
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 174:4979-84. 2005Recent studies in both human and rodents have indicated that in addition to CD4+ T cells, CD8+ T cells play an important role in allergic inflammation...
- Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZRIvan Bilic
Institute of Immunology, Medical University of Vienna, Vienna 1090, Austria
Nat Immunol 7:392-400. 2006Coreceptor expression is tightly regulated during thymocyte development. Deletion of specific Cd8 enhancers leads to variegated expression of CD8alphabeta heterodimers in double-positive thymocytes...
- Differential antigen processing by dendritic cell subsets in vivoDiana Dudziak
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
Science 315:107-11. 2007..Unlike CD8+ DCs that express the cell surface protein CD205, CD8- DCs, which are positive for the 33D1 antigen, are ..
- Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptorsNicolas P Andrews
Department of Pathology, Emory University School of Medicine, Woodruff Memorial Research Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
J Virol 82:4697-705. 2008The CD8 coreceptor is important for positive selection of major histocompatibility complex I (MHC-I)-restricted thymocytes and in the generation of pathogen-specific T cells...
- Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latencyKevin R Mott
Center for Neurobiology and Vaccine Development, D2024, Cedars Sinai Burns and Allen Research Institute, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
J Virol 82:9870-9. 2008..Latency was also significantly reduced in Flt3L(-/-) and CD8(-/-) mice. Interestingly, immunization of Flt3L(-/-) but not CD8(-/-) mice with Flt3L DNA increased latency...
- Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cellsLie Wang
Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Nat Immunol 9:1122-30. 2008..contexts permitted the 'redirection' of major histocompatibility complex class II-restricted thymocytes into the CD8(+) lineage...
- The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-toleranceTaishin Akiyama
Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
Immunity 29:423-37. 2008..These results show that developmental-stage-dependent cooperation between RANK and CD40 promotes mTEC development, thereby establishing self-tolerance...
- The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytesShinya Sakaguchi
Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
Nat Immunol 11:442-8. 2010The CD4 versus CD8 lineage specification of thymocytes is linked to coreceptor expression. The transcription factor MAZR has been identified as an important regulator of Cd8 expression...
- Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte developmentNicola Harker
Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, London NW7 1AA, United Kingdom
J Immunol 186:6368-77. 2011The CD8 gene is silent in CD4(-)CD8(-) double-negative thymocytes, expressed in CD4(+)CD8(+) double-positive cells, and silenced in cells committing to the CD4(+) single-positive (SP) lineage, remaining active in the CD8(+) SP lineage...
- Cd8 enhancer E8I and Runx factors regulate CD8α expression in activated CD8+ T cellsHammad Hassan
Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria
Proc Natl Acad Sci U S A 108:18330-5. 2011Cd8a and Cd8b1 coreceptor gene (Cd8) expression is tightly controlled during T-cell development by the activity of five Cd8 enhancers (E8(I)-E8(V))...
- Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivoStuart Olver
The Cooperative Research Centre for Vaccine Technology and the Queensland Institute of Medical Research, Herston, QLD, Australia
Immunology 139:187-96. 2013Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor ..
- Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 productionP Kanakaraj
R W Johnson Pharmaceutical Research Institute, San Diego, California 92121, USA
J Exp Med 187:2073-9. 1998..Our results demonstrate that IRAK plays an essential proximal role in coordinating multiple IL-1 signaling pathways for optimal induction of cellular responses...
- Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cellsW Ellmeier
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
Immunity 9:485-96. 1998We and others have recently identified a CD8 locus enhancer (E8) that directs expression in mature CD8 single-positive thymocytes and peripheral CD8+ T cells and in extrathymically derived intestinal intraepithelial lymphocytes (IEL)...
- Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potentialPilar Martin
Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain and Faculté de Médecine Pasteur, INSERM U364, Nice, France
Blood 100:383-90. 2002....
- Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13Nobuaki Miyahara
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 172:2549-58. 2004..Th2/CD4 T cells, which secrete IL-4, IL-5, and IL-13, in allergic disease is well established; however, the role of CD8(+) T cells (allergen-induced airway hyperresponsiveness (AHR) and inflammation) is less clear...
- 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCRJung Hyun Park
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 8:1049-59. 2007..Here we identify a homeostatic mechanism that transcriptionally tailors CD8 coreceptor expression in individual CD8+ T cells to the self-specificity of their clonotypic T cell receptor (TCR)...
- Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in miceMiranda S Oakley
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Infect Immun 76:4518-29. 2008..with C57BL/6 mice, which have an ECM-susceptible phenotype, and with mice that have ECM-resistant phenotypes: CD8 knockout and perforin knockout mice on the C57BL/6 background and BALB/c mice...
- Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNAR Zamoyska
Cell 43:153-63. 1985..The nucleotide sequence of cDNA clones encoding each of these polypeptide chains has been determined and shows the difference between the two Lyt-2 polypeptide chains to be in the lengths of their cytoplasmic tails...
- CD8+ T cells are necessary for recognition of allelic, but not locus-mismatched or xeno-, HLA class I transplantation antigensS H Borenstein
Institute of Medical Science, University of Toronto, The Hospital for Sick Children, Toronto, Canada
J Immunol 165:2341-53. 2000..HLA allele) transplantation Ags revealed the following: 1) Although HLAhyb molecules induced stronger xeno-CD8+ T cell responses in vitro, additional effector mechanisms must be active in vivo because HLAnat skin grafts were ..
- Murine hematopoietic cell surface antigen expressionK L Holmes
Immunol Today 9:344-50. 1988
- Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2V P Sukhatme
J Exp Med 161:429-34. 1985..The Leu-2/T8 gene translocates with C kappa to chromosome 8 in a Burkitt lymphoma line carrying a t(2;8) translocation. These data support the hypothesis that Leu-2/T8 is the human homologue of the mouse Lyt-2,3 antigen...
- Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regionsH Nakauchi
Proc Natl Acad Sci U S A 82:5126-30. 1985..Lyt-2 and its human analogue Leu-2 are 56% homologous; analysis indicates that the Ig V-related domains of the two molecules have evolved away from each other faster than the carboxyl-terminal half of the proteins...
- Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8a geneM Banan
Department of Microbiology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA
J Biol Chem 272:18440-52. 1997..The L2a-P1 protein found to be present in all CD8-positive T cell lines tested is SATB1, a known MAR-binding protein...
- The role of CD8(+) T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virusT Kimura
W Harry Feinstone Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
J Virol 74:6117-25. 2000Little is known about the role of CD8(+) T cells infiltrating the neural parenchyma during encephalitis induced by neurovirulent Sindbis virus (NSV)...
- CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivityB Wang
Division of Dermatology, Sunnybrook and Women s College Health Science Centre, Toronto, Ontario, Canada
J Immunol 165:6783-90. 2000The role of CD4(+) vs CD8(+) T cells in contact hypersensitivity (CHS) remains controversial. In this study, we used gene knockout (KO) mice deficient in CD4(+) or CD8(+) T cells to directly address this issue...
- Cutting Edge: Multiple autoimmune pathways in kd/kd miceWayne W Hancock
Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia and the University of Philadelphia School of Medicine, Philadelphia, PA 19104, USA
J Immunol 171:2778-81. 2003..The resulting congenic strain, B6.kd, was mated with partners homozygous for targeted mutations of CD4, CD8, CD28, IL-2, recombinase-activating gene-1 (Rag-1), ICAM-1, or beta(2)-microglobulin...
- Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infectionConstantine Bitsaktsis
Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
J Immunol 172:6894-901. 2004..Resistance to sublethal challenge in both C57BL/6 and BALB/c mice was CD4-, but not CD8-, dependent and required IL-12p40-dependent cytokines, IFN-gamma, and TNF-alpha, but not IL-4...
- Deliberate removal of T cell help improves virus-neutralizing antibody productionMike Recher
Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Nat Immunol 5:934-42. 2004..reduction in CD4(+) T cell help in vivo resulted in potent neutralizing antibody responses without impairment of CD8(+) T cell activity...
- CD4+CD25+ regulatory T cells control innate immune reactivity after injuryThomas J Murphy
Department of Surgery Immunology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:2957-63. 2005..IL-1beta, and IL-6 production by spleen cell populations prepared from wild-type (WT), Rag1(-/-), CD4(-/-), or CD8(-/-) mice 7 days after sham or burn injury...
- Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilizationIngrid G Winkler
Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
J Exp Med 201:1077-88. 2005..These data suggest an unexpected role for serpina1 and serpina3 in regulating the bone marrow hematopoietic microenvironment as well as influencing the migratory behavior of hematopoietic precursors...
- CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infectionGennadiy Zelinskyy
Institut fuer Virologie, Universitaetsklinikum Essen, 45122 Essen, Germany
J Virol 79:10619-26. 2005Virus-specific CD8+ T cells are critical for the control of acute Friend virus (FV) infections, but are rendered impotent by CD4+ regulatory T cells during the chronic phase of infection...
- Differential effect of imipenem treatment on wild-type and NK cell-deficient CD8 knockout mice during acute intra-abdominal injuryVictor T Enoh
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, Texas 77555 0591, USA
Am J Physiol Regul Integr Comp Physiol 290:R685-93. 2006b>CD8 knockout mice depleted of natural killer (NK) cells by treatment with anti-asialoGM1 (CD8KO/alphaAsGM1 mice) are resistant to injury caused by cecal ligation and puncture (CLP). However, CLP-induced injury is complex...
- Crystal structure of the TCR co-receptor CD8alphaalpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolutionD A Shore
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Mol Biol 358:347-54. 2006The CD8 glycoprotein functions as an essential element in the control of T-cell selection, maturation and the TCR-mediated response to peptide antigen...
- Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptorJulien C Marie
Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
Immunity 25:441-54. 2006..Peripheral CD4+ and CD8+ T cells with TGF-beta-receptor II (TGF-betaRII) deficiency activated cytolytic and T helper 1 (Th1) ..
- Essential role for Nix in autophagic maturation of erythroid cellsHector Sandoval
Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 454:232-5. 2008..Our study may also provide insights into molecular mechanisms underlying mitochondrial quality control involving mitochondrial autophagy...
- Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infectionAshlesh K Murthy
South Texas Center for Emerging Infectious Diseases, Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249, USA
Infect Immun 79:2928-35. 2011..Since both perforin and TNF-α are effector mechanisms of CD8(+) T cells, we evaluated the role of CD8(+) T cells during genital Chlamydia muridarum infection and oviduct ..
- Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130NOELLE A HUTCHINS
Brown University Pathobiology Graduate Program, Warren Alpert School of Medicine, Providence, Rhode Island, USA
Am J Pathol 182:742-54. 2013..Although we previously reported increased numbers of Fas ligand expressing CD8(+) T lymphocytes in the septic liver, CD8(+) T-cell deficiency did not reverse the onset of LSEC apoptosis/damage...
- T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell developmentArchna Sharma
Immune Cells and Inflammation Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, United States of America
PLoS ONE 9:e115803. 2014..NKT cells develop from common CD4+ CD8+ double positive (DP) thymocyte precursors after the rearrangement and expression of T cell receptor (TCR) Vα14-Jα..
- CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3Cyril Seillet
Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Blood 121:1574-83. 2013Antiviral immunity and cross-presentation is mediated constitutively through CD8α+ and CD103+ DCs...
- The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationshipsD A Sweetser
Department of Biological Chemistry, Washington University School of Medicine, St Louis, Missouri 63110
J Biol Chem 262:16060-71. 1987..Human gene mapping studies were carried out using a panel of mouse-human somatic cell hybrid clones as well as in situ hybridization to metaphase chromosomes.(ABSTRACT TRUNCATED AT 400 WORDS)..
- Structural polymorphism of V kappa 21 E and V kappa 21 D gene products in laboratory miceD Primi
Eur J Immunol 16:292-6. 1986....
- Genetic mapping of endogenous mouse mammary tumor viruses: locus characterization, segregation, and chromosomal distributionV L Traina
J Virol 40:735-44. 1981..The results are consistent with the view that integration of mouse mammary tumor virus can take place at numerous sites within the genome, and once inserted, these proviruses appear to be relatively stable genetic entities...
- Isolation of P1 bacteriophage clones containing large contiguous segments of the human and mouse loci for the T-cell coreceptor molecule CD8X L Zhang
Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
Genet Anal Tech Appl 11:129-39. 1994The T-lymphocyte coreceptor molecules CD8 (composed of CD8 alpha and CD8 beta chains) and CD4 undergo a complex pattern of regulated expression during T-cell maturation...
- A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin miceV A Wallace
Amgen Institute, Department of Immunology, University of Toronto, Ontario, Canada
Eur J Immunol 24:1463-6. 1994..To determine the role of T cell subsets in the pathogenesis of fibrotic disease, Tsk/+ mice were bred with CD4- and CD8-deficient (CD4-/- and CD8-/-) mice...
- Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritisY Tada
Amgen Institute, Ontario Cancer Institute, Ontario, Canada
J Immunol 156:4520-6. 1996..We studied CIA in CD4- or CD8-deficient DBA/1 mice to further define the roles of CD4+ and CD8+ T cells in the disease...
- Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient miceM Huber
Institut für Klinische Mikrobiologie und Immunologie, Friedrich Alexander Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
Infect Immun 66:3968-70. 1998The results of earlier investigations that tested whether CD8(+) T cells are required in the defense against Leishmania major have been inconsistent. We used CD8-deficient mice to directly address this issue...
- Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: identification of regulatory cellsF D Shi
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
J Immunol 162:5757-63. 1999..changes in the AChR-pretreated C57BL/6 wild-type (wt) mice were comparable with those observed in AChR-pretreated CD8-/- mice, indicating that CD8+ T cells were not required for the generation of nasal tolerance...
- CD8+ CTLs are essential for protective immunity against Encephalitozoon cuniculi infectionI A Khan
Departments ofMedicine and Microbiology and Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 162:6086-91. 1999..Whereas CD4-/- animals resolved the infection, mice lacking CD8+ T cells or perforin gene succumbed to parasite challenge. The data obtained in these studies suggest that E...
- The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart diseaseP Liu
Heart and Stroke Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
Nat Med 6:429-34. 2000..These data identify a previously unknown function of Src family kinases and indicate that p56lck is the essential host factor that controls the replication and pathogenicity of CVB3...
- CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplantsM P Fischbein
Department of Microbiology, Immunology, and Molecular Genetics, Division of Cardiothoracic Surgery, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
J Immunol 165:7316-22. 2000..The return of rejection appears to be a CD8(+) lymphocyte-dependent process, noted by the absence of rejection in FGK45-treated recombinase-activated gene ..
- Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failureM J Burne
Division of Nephrology, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
J Clin Invest 108:1283-90. 2001..T cell subsets to postischemic injury and found that mice deficient in CD4(+) T cells, but not mice deficient in CD8(+) T cells, were significantly protected from ARF...
- CD8 alpha-deficient mice are highly susceptible to 5-fluorouracil-induced lethalityNaoto Itoh
Laboratory of Host Defense, Research Institute for Disease Mechanisms and Control, Nagoya University School of Medicine, Nagoya 466 8550, Japan
Clin Diagn Lab Immunol 9:550-7. 2002Intestinal intraepithelial lymphocytes (i-IEL) expressing CD8 alpha are located in the intestine and may confer protection against invasion of intestinal microflora...
- The variable, C(H)1, C(H)2 and C(H)3 domains of Ig heavy chain are dispensable for pre-BCR function in transgenic miceStefan A Muljo
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
Int Immunol 14:577-84. 2002..extracellular domains except for C(H)4 were replaced by an irrelevant Ig superfamily ectodomain from the human CD8 alpha protein...
- Regulatory functions of CD8+CD28- T cells in an autoimmune disease modelNader Najafian
Brigham and Women s Hospital, Boston, Massachusetts, USA
J Clin Invest 112:1037-48. 2003b>CD8+ T cell depletion renders CD28-deficient mice susceptible to experimental autoimmune encephalomyelitis (EAE). In addition, CD8-/-CD28-/- double-knockout mice are susceptible to EAE...
- Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejectionBenjamin D Ehst
Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA
Am J Transplant 3:1355-62. 2003The goal of this study was the development of a system in which the cooperative interactions between CD4 and CD8 T cells specific for defined peptides from a single minor histocompatibility antigen could be studied...
- Liver dendritic cells present bacterial antigens and produce cytokines upon Salmonella encounterCecilia Johansson
Department of Cell and Molecular Biology, Section for Immunology, Lund University, Lund, Sweden
J Immunol 172:2496-503. 2004..Thus, liver DC can internalize and process Salmonella for peptide presentation to CD4(+) and CD8(+) T cells and elicit proinflammatory cytokine production upon Salmonella encounter, suggesting that DC in the ..
- Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligandMichele M Kosiewicz
Department of Microbiology and Immunology, University of Louisville Health Sciences Center, Louisville, KY 40202, USA
Int Immunol 16:697-706. 2004..class II knockout mice were unable to mediate tolerance in primed mice and failed to induce not only CD4, but also CD8 regulatory T cells...
- STAT5 is required for thymopoiesis in a development stage-specific mannerJoonsoo Kang
Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 173:2307-14. 2004....
- Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient miceRamireddy Bommireddy
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Cell Immunol 232:96-104. 2004..we show that elimination of T but not B cells is sufficient for the reversal, but elimination of either CD4+ or CD8+ cells is not...
- Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimerHsiu Ching Chang
Laboratory of Immunobiology, Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Immunity 23:661-71. 2005..The implications of these findings and additional CD8alpha mutational studies for CD8alphabeta- versus CD8alphaalpha-MHCI binding are discussed...
- Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytesChi Wang Ip
Department of Neurology, University of Wuerzburg, D 97080 Wuerzburg, Germany
J Neurosci 26:8206-16. 2006..Based on the observation that in white matter tracts of these mutants both CD8+ T-lymphocytes and CD11b+ macrophage-like cells are numerically elevated, we tested the hypothesis that these cells ..
- The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiationMichel Mallaun
Laboratory of Transplantation Immunology and Nephrology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
J Immunol 180:8211-21. 2008The CD8 coreceptor contributes to the recognition of peptide-MHC (pMHC) ligands by stabilizing the TCR-pMHC interaction and enabling efficient signaling initiation...
- CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 productionKok Loon Wong
Immunology Program and Department of Microbiology, Centre for Life Sciences, National University of Singapore, Singapore
Eur J Immunol 38:2251-62. 2008CD8alpha(+) DC are implicated as the principle DC subset for cross-presentation and cross-priming of cytotoxic CD8 T cell responses...
- Identification of CD4(-)CD8(-) double-negative natural killer T cell precursors in the thymusNyambayar Dashtsoodol
Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
PLoS ONE 3:e3688. 2008..well known that CD1d-restricted Valpha14 invariant natural killer T (NKT) cells are derived from cells in the CD4(+)CD8(+) double-positive (DP) population in the thymus...
- CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axisSheng Zhang
Department of Pathology and Molecular Medicine, McMaster University, Ontario, Canada
Eur J Immunol 39:1252-9. 2009..Our results offer a possibility to elicit specific anti-tumor responses without triggering unwanted tissue autoimmune diseases...
- Themis, a T cell-specific protein important for late thymocyte developmentRenaud Lesourne
Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Nat Immunol 10:840-7. 2009..thymocytes transition through a stage during which T cell antigen receptor (TCR) signaling controls CD4-versus-CD8 lineage 'choice' and subsequent maturation...
- Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in miceMiranda S Oakley
Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, MD, USA
PLoS ONE 4:e6793. 2009..We find that OX40, a marker of both T cell activation and memory, is selectively upregulated in the brain during ECM and its distribution among CD4(+) and CD8(+) T cells accumulated in the brain vasculature is approximately equal.
- Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selectionIsaac Engel
La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Exp Med 207:1015-29. 2010..with an invariant V alpha14-J alpha18 rearrangement (V alpha14 invariant [V alpha14i] NKT cells) are either CD4(+)CD8(-) or CD4(-)CD8(-)...
- Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteinsDanielle F Atibalentja
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 186:1421-31. 2011..Two conventional dendritic cells (cDCs), the CD8α(+)Sirpα(-)CD11c(hi) (CD8α(+) cDC) and the CD8α(-)Sirpα(+)CD11c(hi) (Sirpα(+) cDC), were previously ..
- Caspase-3 is transiently activated without cell death during early antigen driven expansion of CD8(+) T cells in vivoScott McComb
Department of Biochemistry, NRC Institute for Biological Sciences, University of Ottawa, Ottawa, Canada
PLoS ONE 5:e15328. 2010b>CD8(+) T cell responses develop rapidly during infection and are swiftly reduced during contraction, wherein >90% of primed CD8(+) T cells are eliminated...
- Interplay between CD8α+ dendritic cells and monocytes in response to Listeria monocytogenes infection attenuates T cell responsesDilnawaz Kapadia
Division of Hematology Oncology, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e19376. 2011..b>CD8α(+) dendritic cells (DCs) are an important coordinator of early immune responses to the intracellular bacteria ..
- Nucleotide sequence analysis of the C.AKR Lyt-2a gene: structural polymorphism in alleles encoding the Lyt-2.1 T-cell surface alloantigenH J Youn
Department of Microbiology, University of Texas, Austin 78712
Immunogenetics 28:345-52. 1988....
- gamma-Glutamyl cyclotransferase: a new genetic polymorphism in the mouse (Mus musculus) linked to Lyt-2N Tulchin
Genetics 99:109-16. 1981..0 +/- 2.5 centimorgans...
- Endogenous nonecotropic proviruses mapped with oligonucleotide probes from the long terminal repeat regionW N Frankel
Jackson Laboratory, Bar Harbor, Maine 04609
Mamm Genome 5:275-81. 1994..Together with proviruses identified previously with env probes, the LTR probe-reactive elements represent the majority of endogenous murine leukemia proviruses in the mouse genome...
- TREATMENT OF BURN-INDUCED IMMUNOSUPPRESSIONEdward Sherwood; Fiscal Year: 2002..Administration of glucan to thermally injured mice will promote IL-12, IL-18 and IFNgamma production, increase type 1 T cell predominance and enhance resistance to infection. ..
- Modulation of type I diabetes with NKT cellsLuc Van Kaer; Fiscal Year: 2006..These studies will provide a better understanding of the immunological mechanisms that result in autoimmunity, and may lead to the development of novel agents for treatment of type I diabetes and other autoimmune diseases. ..
- Analyzing and modulating immunoregulatory defects in autoimmune disease.Michele M Kosiewicz; Fiscal Year: 2010..abstract_text> ..
- Modulation of EAE with ligand-activated NKT cellsLuc Van Kaer; Fiscal Year: 2005..These reagents will permit the selective activation of distinct adaptive immune responses in vivo, which could be exploited for therapeutic intervention in MS and other human autoimmune diseases. ..
- Requirements for regulatory T cell developmentMICHELE KOSIEWICZ; Fiscal Year: 2003..These experiments may determine the requirements for regulatory T cell development, and thereby, identify pathways that can be therapeutically manipulated to prevent and/or treat autoimmune diseases. ..
- Sex-based differences in regulatory T cell responsesMICHELE KOSIEWICZ; Fiscal Year: 2004..The results of these studies will provide important information that can lead to the development of novel therapies for the prevention and treatment of autoimmune disease. ..
- The function of membrane vesiculation in CTLA-4-mediate*Joonsoo Kang; Fiscal Year: 2005..To date there has been limited advancement on the ability to increase CTLA-4 function. The proposed model of CTLA-4 function would provide a novel means to increase CTLA-4-mediated inhibition in vivo. ..
- Facility renovation to expand mouse barrier spaceLINDA TOTH; Fiscal Year: 2005..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
- MOLECULAR BASIS OF CD8 CO-RECEPTOR FUNCTIONHsiu Ching Chang; Fiscal Year: 2004b>CD8 has been shown to be critically involved in class I MHC-restricted T cell development and antigen recognition function...
- Determination of Mechanism of T cell Lineage CommittmentJoonsoo Kang; Fiscal Year: 2006..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
- ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICELINDA TOTH; Fiscal Year: 2006..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
- AFP-Based Immunotherapy for Hepatocellular CarcinomaAntoni Ribas; Fiscal Year: 2006..In summary, I propose a clinically-oriented research program that translates this original work into novel, evidence-based immnunotherapy trials for hepatocellular carcinoma. ..
- BEHAVIORAL AND PHYSIOLOGIC PATHOBIOLOGY OF MICELINDA TOTH; Fiscal Year: 2006..abstract_text> ..
- Mechanisms of CTLA-4 FunctionJoonsoo Kang; Fiscal Year: 2007..Understanding these processes is critical for designing novel therapeutic approaches for vaccine development, autoimmune disease, and in transplant and tumor immunology. ..
- Sleep and fatigue during renal disease in miceLINDA TOTH; Fiscal Year: 2008..Achieving this ambitious goal is feasible given the experience of my laboratory in surveying sleep phenotypes in other studies involving large numbers of mice. [unreadable] [unreadable]..
- Development of Cellular Assays of Dengue Virus InfectionPriscilla Yang; Fiscal Year: 2008..These inhibitors can be used to study how dengue virus interacts with its host, and they may also be useful in developing therapies for the treatment of dengue virus infections. [unreadable] [unreadable] [unreadable]..
- Regulation of T cell development by SOX13Joonsoo Kang; Fiscal Year: 2009..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
- IMMUNOMODULATORY STRATEGIES IN AUTOIMMUNE GASTRITISMICHELE KOSIEWICZ; Fiscal Year: 2002..Accumulating evidence suggests that CD4 and CD8 regulatory T cells are induced and mediate antigen-specific tolerance in this system...