Genomes and Genes
Gene Symbol: Cd40lg
Description: CD40 ligand
Alias: CD154, CD40-L, Cd40l, HIGM1, IGM, IMD3, Ly-62, Ly62, T-BAM, TRAP, Tnfsf5, Tnlg8b, gp39, CD40 ligand, T-cell antigen Gp39, TNF-related activation protein, tumor necrosis factor ligand 8b, tumor necrosis factor ligand superfamily member 5
Publications123 found, 100 shown here
- CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1Andreas Zirlik
Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 115:1571-80. 2007Strong evidence supports a role for CD40 ligand (CD40L) as marker and mediator of inflammatory diseases such as atherosclerosis...
- Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infectionL Soong
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
Immunity 4:263-73. 1996To study the role of CD40 ligand (CD40L) in the host immune responses against intracellular pathogens, we infected CD40L knockout (CD40L-/-) mice with Leishmania amazonensis...
- CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokinesR S Kornbluth
Department of Medicine, University of California, San Diego, and Department of Veterans Affairs Medical Center, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 95:5205-10. 1998..Instead, direct cell-cell contact between macrophages and cells engineered to express CD40L (also known as CD154) resulted in the production of large amounts of macrophage inflammatory protein-1alpha and -1beta, and RANTES (all ..
- CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40Y Yang
Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Science 273:1862-4. 1996The role of CD40 ligand (CD40L) in the primary activation of T cells is not clear...
- CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathwaysMark R Nicolls
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
J Immunol 169:4831-9. 2002b>CD154 and LFA-1 (CD11a) represent conceptually distinct pathways of receptor/ligand interactions (costimulation and adhesion/homing, respectively) that have been effectively targeted to induce long-term allograft acceptance and tolerance...
- Indefinite survival of neonatal porcine islet xenografts by simultaneous targeting of LFA-1 and CD154 or CD45RBGina R Rayat
Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
Diabetes 54:443-51. 2005..Previous studies demonstrate that combined anti-lymphocyte function-associated antigen-1 (LFA-1) plus anti-CD154 therapy results in a robust form of islet allograft tolerance not observed with either individual monotherapy...
- Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centersS Han
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
J Immunol 155:556-67. 1995..compared the roles of CD40L and B7-2 in the initiation and maturation of humoral immunity by administering anti-CD40 ligand (L) or anti-B7-2 Ab during the early (days -1 to 3) or late (days 6-10) phases of primary responses to thymus-..
- A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activationD Graf
Robert Koch Institute, Berlin, Germany
Eur J Immunol 25:1749-54. 1995b>TRAP is a tumor necrosis factor (TNF)-related, 33-kDa type II transmembrane protein almost exclusively expressed on the surface of activated CD4+ T lymphocytes...
- Mice deficient for the CD40 ligandJ Xu
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510
Immunity 1:423-31. 1994To study the potential roles of CD40L in immune responses, we generated CD40L-deficient mice by gene targeting...
- Humoral immune responses in CD40 ligand-deficient miceB R Renshaw
Department of Molecular Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101
J Exp Med 180:1889-900. 1994Individuals with X-linked hyper-IgM syndrome fail to express functional CD40 ligand (CD40L) and, as a consequence, are incapable of mounting protective antibody responses to opportunistic bacterial infections...
- Impairment of antigen-specific T-cell priming in mice lacking CD40 ligandI S Grewal
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Nature 378:617-20. 1995Lack of functional expression of CD40 ligand (CD40L) on T cells results in hyper-IgM syndrome (HIGM1), a human immunodeficiency associated with a severely impaired humoral immune response that is consistent with defects in B-cell ..
- CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL responseP Borrow
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
J Exp Med 183:2129-42. 1996The ligand for CD40 (CD40L) is expressed on the surface of activated CD4+ T cells and its role in T-B cell collaborations and thymus-dependent humoral immunity is well established...
- Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signalsA I Jaiswal
Department of Biology, University of California San Diego 92093 0063, USA
Int Immunol 8:275-85. 1996We have investigated the roles of TCR and accessory co-stimulatory signals in the induction of CD40 ligand (CD40L) on CD4 cells...
- Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitisI S Grewal
Howard Hughes Medical Institute, and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Science 273:1864-7. 1996The mechanism of CD40 ligand (CD40L)-mediated in vivo activation of CD4(+) T cells was examined by investigation of the development of experimental allergic encephalomyelitis (EAE) in CD40L-deficient mice that carried a transgenic T cell ..
- Reduction of atherosclerosis in mice by inhibition of CD40 signallingF Mach
Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 394:200-3. 1998..Cells in human atherosclerotic lesions express the immune mediator CD40 and its ligand CD40L (also known as CD154 or gp39)...
- CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virusA R Thomsen
Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark
J Immunol 161:4583-90. 1998b>CD40 ligand (CD40L) is an important molecule that is known to be involved in T-B collaboration and certain aspects of cell-mediated immunity. However, its role in antiviral immunity has not been clearly defined as of yet...
- Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactionsM N Kweon
Department of Oral Biology, Immunobiology Vaccine Center, University of Alabama Medical Center, Birmingham 35294, USA
J Immunol 162:1904-9. 1999b>CD40 ligand (CD40L) gene-disrupted (CD40L-/-) mice were employed to examine the role of costimulatory signals via CD40L-CD40 interactions in mucosally induced tolerance...
- Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host diseaseJ E Buhlmann
Department of Microbiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 162:4373-6. 1999..We extend these data to show that in the absence of CD154 function, donor T cells are unable to expand or generate high level anti-host CTL activity...
- CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responsesJ K Whitmire
Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Immunol 163:3194-201. 1999This study documents a striking dichotomy between CD4 and CD8 T cells in terms of their requirements for CD40-CD40 ligand (CD40L) costimulation...
- Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responsesS O Andreasen
Institute of Medical Microbiology, University of Copenhagen, Copenhagen, Denmark
J Immunol 164:3689-97. 2000The primary aim of this report was to evaluate the immune responses of CD40 ligand-deficient (CD40L-/-) mice infected with two viruses known to differ markedly in their capacity to replicate in the host...
- The roles of CD28 and CD40 ligand in T cell activation and toleranceK C Howland
Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 164:4465-70. 2000Costimulation of T cell activation involves both the B7:CD28 as well as the CD40 ligand (CD40L):CD40 pathway...
- Role of CD40-CVD40L in mouse severe malariaP F Piguet
Department of Pathology, University of Geneva, 1 Rue M Servet, CMU, 1211 Geneva, Switzerland
Am J Pathol 159:733-42. 2001We explored the role of CD40-CD40L (CD154) in the severe malaria elicited by Plasmodium berghei anka infection in mice...
- Does CD40 ligation induce B cell negative selection?Jesus Martinez-Barnetche
Research Unit on Autoimmune Diseases, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 03020 México City, Distrito Federal, Mexico
J Immunol 168:1042-9. 2002Binding of CD154 to its receptor, CD40, provides costimulation for mature B cell activation and differentiation in response to Ag receptor signals. In mice, early B cell precursors express CD40, but its function at this stage is unknown...
- CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanismPatrick Andre
The Center for Blood Research, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 8:247-52. 2002b>CD40L, a member of the tumor necrosis factor family of ligands, plays a major role in immune responses via its receptor, CD40. Recently, CD40L has been detected on the surfaces of activated platelets and shown to activate endothelium...
- Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interactionAndrew S MacDonald
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Immunol 168:4643-9. 2002The role of CD40/CD154 interaction during infection has primarily focused on pathogens that drive inflammatory Th1 responses...
- The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12Byung O Lee
Trudeau Institute, Saranac Lake, NY 12983, USA
J Exp Med 196:693-704. 2002b>CD40 ligand (CD154) expression on activated T cells can be separated into an early TCR-dependent phase, which occurs between 0 and 24 h after activation, and a later extended phase, which occurs after 24 h and is reciprocally regulated ..
- Role of CD40 ligand in amyloidosis in transgenic Alzheimer's miceJun Tan
The Roskamp Institute, Department of Psychiatry, University of South Florida, 3515 East Fletcher Avenue, Tampa, Florida 33613, USA
Nat Neurosci 5:1288-93. 2002We have shown that interaction of CD40 with CD40L enables microglial activation in response to amyloid-beta peptide (Abeta), which is associated with Alzheimer's disease (AD)-like neuronal tau hyperphosphorylation in vivo...
- T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activationSimon Fillatreau
Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
J Exp Med 197:195-206. 2003..Crucially, the up-regulation of OX40L (on antigen-presenting cells) and CXCR-5 (on T cells) are CD40-dependent events and we show that T cells do not migrate to follicles in immunized OX40-deficient mice...
- Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infectionDevon J Shedlock
Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
J Immunol 170:2053-63. 2003CD4 T cells are known to assist the CD8 T cell response by activating APC via CD40-CD40 ligand (L) interactions...
- Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartmentsBennett D Elzey
The University of Iowa, Department of Urology, Iowa City, IA 52242, USA
Immunity 19:9-19. 2003..events through the release of chemokines, cytokines, and a number of immunomodulatory ligands, including CD154. We hypothesized that platelet-derived CD154 modulates adaptive immunity...
- NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cellsIan F Hermans
Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 171:5140-7. 2003..Thus, iNKT cells exert a significant influence on the efficacy of immune responses to soluble Ag by modulating DC function...
- CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cellsPau Serra
Julia McFarlane Diabetes Research Centre, University of Calgary, Faculty of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
Immunity 19:877-89. 2003We report that disruption of CD154 in nonobese diabetic (NOD) mice abrogates the helper function of CD4+CD25- T cells without impairing the regulatory activity of CD4+CD25+ T cells...
- Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cellsJoseph C Sun
Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
J Immunol 172:3385-9. 2004..Listeria monocytogenes and lymphocytic choriomeningitis virus, we found no evidence of any requirement for CD40-CD40 ligand interaction at this level...
- The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulationShin ichiro Fujii
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
J Exp Med 199:1607-18. 2004..Surprisingly, DCs from CD40(-/-) and CD40L(-/-) mice did not elicit CD4(+) and CD8(+) T cell immunity, even though the DCs exhibited presented ovalbumin on ..
- Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cellsUdo Bavendiek
Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass02115, USA
Arterioscler Thromb Vasc Biol 25:1244-9. 2005Recent research suggests a central role for CD40 ligand (CD40L) in atherogenesis. However, the relevant cellular source of this proinflammatory cytokine remains unknown...
- CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusionMami Ishikawa
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
Circulation 111:1690-6. 2005CD40/CD40 ligand (CD40L) signaling contributes to proinflammatory and prothrombogenic responses in the vasculature. CD40/CD40L expression is elevated in patients after a transient ischemic attack or stroke...
- Differential expression and regulation of murine CD40 in regional vascular bedsThorsten Vowinkel
Dept of Molecular and Cellular Physiology, LSU Health Sciences Ctr, 1501 Kings Hwy, Shreveport, LA 71130 3932, USA
Am J Physiol Heart Circ Physiol 290:H631-9. 2006There is emerging evidence for a role of the CD40/CD40 ligand (CD40L) dyad as a signaling mechanism in different inflammatory conditions...
- The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligandFabrina M C Gaspal
MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
Eur J Immunol 36:1665-73. 2006..type 2 antigens in mice depends on intact signals through CD40, but does not depend on T cell-derived CD40-ligand (CD154)...
- Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cellsDaniel H D Gray
Monash Immunology and Stem Cell Laboratories MISCL, Level 3, STRIP, Building 75, Monash University, Wellington Road, Clayton, Victoria, 3800, Australia
Blood 108:3777-85. 2006..Overall, these studies show that the thymic stroma is a surprisingly dynamic population and may have a more direct role in negative selection than previously thought...
- TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responsesAlex K Heer
Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
J Immunol 178:2182-91. 2007..Notably, direct TLR signaling on B cells or T cell help through the CD40-CD40L interaction was sufficient to support B cell proliferation and IgG1 production, whereas IFN-alpha was critical for ..
- Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific mannerYoshinobu Koguchi
Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
Blood 110:2520-7. 2007b>CD40 ligand (CD40L) is an essential effector cytokine for macrophage activation, dendritic cell licensing, and T-cell-dependent antibody responses...
- CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injuryGuohong Li
Cardiovascular Division, Robert M Berne Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA, USA
Am J Pathol 172:1141-52. 2008High levels of circulating soluble CD40 ligand (sCD40L) are frequently found in patients with hypercholesterolemia, diabetes, ischemic stroke, or acute coronary syndromes, predicting an increased rate of atherosclerotic plaque rupture ..
- NK T cells provide lipid antigen-specific cognate help for B cellsElizabeth A Leadbetter
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:8339-44. 2008..B cells is shown to involve cognate help from CD1d-instructed lipid-specific iNK T cells, with help provided via CD40L, B7-1/B7-2, and IFN-gamma, but not IL-4...
- CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 productionKok Loon Wong
Immunology Program and Department of Microbiology, Centre for Life Sciences, National University of Singapore, Singapore
Eur J Immunol 38:2251-62. 2008..Activated CD8 T cells use a combination of IFN-gamma and CD40L, which is rapidly up-regulated post-stimulation, to prime DC for IL-12p70 production during an antigen-specific ..
- Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergyNeil B Lineberry
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 181:1622-6. 2008..ubiquitin ligase GRAIL (gene related to anergy in lymphocytes) regulates expression of the costimulatory molecule CD40L on CD4 T cells...
- The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-toleranceTaishin Akiyama
Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
Immunity 29:423-37. 2008..These results show that developmental-stage-dependent cooperation between RANK and CD40 promotes mTEC development, thereby establishing self-tolerance...
- Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responsesElizabeth B Wilson
Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences and University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 181:7445-8. 2008..IL-2-deficient OT-II cells were unable to provide help, although they responded to Ag in vivo and up-regulated CD40 ligand in vitro...
- Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humansCarmela De Santo
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
J Clin Invest 118:4036-48. 2008..These findings identify what we believe to be a novel immunomodulatory role of iNKT cells, which we suggest could be harnessed to abolish the immunosuppressive activity of MDSCs during IAV infection...
- Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60Su Jeong Ryu
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
Blood 113:4273-80. 2009..Adoptively transferred memory CD8 T cells did not proliferate in CD40L(-/-) hosts...
- Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cellsSusan Johnson
Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australiaia
Immunity 30:218-27. 2009..CD40L-deficient (Cd40lg(-/-)) DCs are suboptimal both in vivo in bone marrow chimera experiments and in vitro in mixed lymphocyte ..
- T follicular helper cells differentiate from Th2 cells in response to helminth antigensArielle Glatman Zaretsky
Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Exp Med 206:991-9. 2009..TFH cell development after immunization failed to occur in mice lacking B cells or CD154. The relationship of TFH cells to the Th2 lineage was confirmed when TFH cells were found to develop from CXCR5(-) ..
- In vivo post-transcriptional regulation of CD154 in mouse CD4+ T cellsStefano Vavassori
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA
Eur J Immunol 39:2224-32. 2009Interactions between CD40 and its ligand CD154 are involved in the progression of both cell mediated and innate immunity...
- Soluble CD40 ligand impairs the function of peripheral blood angiogenic outgrowth cells and increases neointimal formation after arterial injuryMihail Hristov
Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
Circulation 121:315-24. 2010Recent work has revealed an essential involvement of soluble CD40 ligand (sCD40L) in inflammation and atherosclerosis...
- Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosisDirk Lievens
Department of Pathology, Maastricht Center for Atherosclerosis Research, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Blood 116:4317-27. 2010b>CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic and inflammatory contributions of platelet CD40L in atherosclerosis...
- Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responsesMelanie Wiesel
Institute for Microbiology, Swiss Federal Institute of Technology Zurich ETH Zurich, Zurich, Switzerland
J Immunol 185:5188-97. 2010..cells promote vaccinia virus-specific CD8(+) T cell responses via two interconnected synergistic pathways: First, CD40L expressed by activated CD4(+) T cells instructs dendritic cells to produce bioactive IL-12p70, which is directly ..
- A protective role for CD154 in hepatic steatosis in miceJulien Villeneuve
INSERM U889, National Institute for Health and Medical Research U889, Bordeaux University, F 33076 Bordeaux, France
Hepatology 52:1968-79. 2010..Herein, we studied the role of CD154, a key mediator of inflammation, in hepatic steatosis...
- Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathwayDaniel Yacoub
Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, Quebec, Canada
Arterioscler Thromb Vasc Biol 30:2424-33. 2010b>CD40 ligand is a thromboinflammatory molecule that predicts cardiovascular events...
- Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive miceMadhav D Sharma
Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912, USA
Immunity 33:942-54. 2010..Help from Treg cells was dependent on CD40L, and (unlike help from conventional non-Treg CD4(+) cells) did not require preactivation or prior exposure to ..
- Stimulation-dependent induction of CD154 on a subset of CD4+ FoxP3+ T-regulatory cellsWen Li
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Int Immunopharmacol 11:1205-10. 2011CD40-ligand/CD154 is predominantly expressed on activated CD4 T cells and plays a central role in regulating CD4 T-cell-dependent responses...
- Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitroYoshinobu Koguchi
Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
J Immunol 187:626-34. 2011b>CD40L is critically important for the initiation and maintenance of adaptive immune responses. It is generally thought that CD40L expression in CD4(+) T cells is regulated transcriptionally and made from new mRNA following Ag recognition...
- Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligandAshish Jain
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
Blood 118:3811-7. 2011X-linked hyper IgM syndrome (XHM) is a combined immune deficiency disorder caused by genetic alterations in CD40 ligand. The purpose of this study was to investigate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the ..
- Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary responseShirley G K Seah
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Australia
J Leukoc Biol 93:145-54. 2013The helper-dependent pathway of priming CD8(+) T cells involves "licensing" of DCs by CD40L on CD4(+) T cells. The helper-independent ("helpless") pathways elicited by many viruses, including influenza, are less widely understood...
- Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disordersDonna C Davidson
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
PLoS ONE 7:e51793. 2012..Consistently, we have previously shown that levels of the inflammatory mediator soluble CD40L (sCD40L) are elevated in the circulation of HIV-infected, cognitively impaired individuals as compared to their ..
- Molecular and biological characterization of a murine ligand for CD40R J Armitage
Department of Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101
Nature 357:80-2. 1992..Here we report the cloning of a ligand for CD40 that is expressed on the cell surface of activated T cells and mediates B-cell proliferation in the absence of co-stimulus, as well as IgE production in the presence of interleukin-4...
- CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodesA M Moodycliffe
Department of Immunology 178, M D Anderson Cancer Center, Houston, TX 77030, USA
J Exp Med 191:2011-20. 2000Whereas CD40-CD40 ligand interactions are important for various dendritic cell (DC) functions in vitro, their in vivo relevance is unknown...
- CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infectionVanja Lazarevic
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Immunity 19:823-35. 2003..In contrast, CD40L(-/-) mice were resistant to M. tuberculosis...
- Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survivalRobin Lesley
Howard Hughes Medical Institute and Department of Microbiology and Immunology, and Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143 7242, USA
Proc Natl Acad Sci U S A 103:10717-22. 2006..Mixed bone marrow chimera experiments reveal that, under homeostatic conditions, the CD40L-CD40 pathway can augment autoreactive B cell survival in a non-cell-autonomous manner...
- Induction of B cell costimulatory function by recombinant murine CD40 ligandM K Kennedy
Department of Immunobiology, Immunex Research and Development Corporation, Seattle, WA 98101
Eur J Immunol 24:116-23. 1994..of B cell growth and differentiation involves an interaction between CD40, a B cell surface molecule, and the CD40 ligand (CD40L) which is expressed on activated CD4+ T cells...
- Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cellsYoshinobu Koguchi
Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS ONE 7:e31296. 2012b>CD40L is essential for the development of adaptive immune responses. It is generally thought that CD40L expression in CD4(+) T cells is regulated transcriptionally and made from new mRNA following antigen recognition...
- Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTVA V Chervonsky
Section of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, Connecticut 06510, USA
Immunity 3:139-46. 1995The propagation of mouse mammary tumor virus (MMTV) has been analyzed in mice defective for expression of CD40 ligand (CD40L)...
- Genomic organization and chromosomal localization of mouse Eplg2, a gene encoding a binding protein for the receptor tyrosine kinase elkF A Fletcher
Immunex Research and Development Corporation, Seattle, Washington 98101
Genomics 24:127-32. 1994..The first intron comprises approximately 8.5 kb of the entire 12-kb genomic sequence. Eplg2 was mapped to the mouse X chromosome by interspecific backcross analysis and is tightly linked to the androgen receptor (Ar) locus...
- Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system developmentP M Smallwood
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 93:9850-7. 1996..Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function...
- Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondiiE N Villegas
Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
J Immunol 163:3344-53. 1999..mice revealed that IL-12 was required for T cell production of IFN-gamma and this was independent of the CD40/CD40 ligand interaction...
- Cloning, characterization, and chromosomal localization of Pnck, a Ca(2+)/calmodulin-dependent protein kinaseH P Gardner
Department of Molecular and Cellular Engineering, Division of Endocrinology, Diabetes, and Metabolism, 612 Biomedical Research Building II III, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania, 19104 6160, USAC
Genomics 63:279-88. 2000....
- Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administrationY P de Jong
Division of Immunology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Gastroenterology 119:715-23. 2000..b>CD154 (CD40L/gp39), a member of the tumor necrosis factor (TNF) family, is up-regulated on T cells on activation and has ..
- CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplantsM P Fischbein
Department of Microbiology, Immunology, and Molecular Genetics, Division of Cardiothoracic Surgery, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
J Immunol 165:7316-22. 2000..Importantly, this study provides evidence that CD40 ligand-targeted therapies may prevent chronic rejection only in strain combinations where CD4(+) lymphocyte help is ..
- Murine B1 B cells require IL-5 for optimal T cell-dependent activationL D Erickson
Department of Pathology and Immunology Graduate Program, University of Iowa College of Medicine, Iowa City, IA 52242, USA
J Immunol 166:1531-9. 2001T helper cell-driven activation of murine B cells has been shown to depend upon CD40-CD40 ligand (CD40L) interactions and a defined set of cytokines...
- Genetic analysis of testis weight and fertility in an interspecies hybrid congenic strain for Chromosome XR W Elliott
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, New York State Department of Health, Buffalo 14263, USA
Mamm Genome 12:45-51. 2001..8 map units for Ihtw1. This region of the genetic map is orthologous to the region on human Chr X containing the gene for the Borjeson-Forssman-Lehman syndrome, an inherited disease in which males show microorchidism...
- The development of a Th1-type response and resistance to Leishmania major infection in the absence of CD40-CD40L costimulationU M Padigel
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 167:5874-9. 2001CD40-CD40L interactions have been shown to be essential for the production of IL-12 and IFN-gamma and control of L. major infection. In contrast, C57BL/6 mice deficient in CD28 develop a dominant Th1-type response and heal infection...
- CD154-dependent priming of diabetogenic CD4(+) T cells dissociated from activation of antigen-presenting cellsAbdelaziz Amrani
Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Center, The University of Calgary, Faculty of Medicine, 3330 Hospital Drive N W, Calgary, Alberta, Canada T2N 4N1
Immunity 16:719-32. 2002..or I-A(g7)-restricted beta cell-autoreactive T cells in monoclonal TCR-transgenic NOD mice expressing or lacking CD154. 8.3-NOD...
- [Regulation of B lymphocyte activation and tolerance by costimulation and co-receptors]Takeshi Tsubata
Tanpakushitsu Kakusan Koso 47:2248-53. 2002
- Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanismsGulcin Demirci
Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Immunol 171:3878-85. 2003..is determined by the interplay of diverse islet-specific T cell subsets whose activation is regulated by CD28/CD154 costimulatory signals and the common gamma-chain (gammac; a shared signaling element by receptors for IL-2, IL-4, ..
- CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant toleranceLamis Z Jarvinen
Department of Microbiology and Immunology, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Transplantation 76:1375-9. 2003..known that the infusion of whole blood from donors (donor-specific transfusion) into recipients combined with anti-CD154 therapy can prolong allograft survival...
- Helper requirements for generation of effector CTL to islet beta cell antigensGeorg M N Behrens
Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Immunol 172:5420-6. 2004..This provides insight into the helper requirements for adoptive transfer immunotherapy of tumors and suggests key points for inhibition of CTL-mediated autoimmunity...
- Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sitesJudie Boisvert
Department of Pathology, University of California, San Francisco, CA 94143, USA
J Immunol 173:3647-52. 2004..In this study, we show that the CD40-CD154 receptor-ligand pair is also highly concentrated into a central region of the synapse on mouse lymphocytes only ..
- Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cellsHelene Bour-Jordan
UCSF Diabetes Center, University of California at San Francisco, San Francisco, California 94143, USA
J Clin Invest 114:979-87. 2004..CD28-B7 and CD40 ligand-CD40 (CD40L-CD40) costimulatory pathways affect the development of disease and are promising therapeutic ..
- CD40 ligand (CD154) takes part in regulation of the transition to mononuclear cell dominance during peritonitisJulia Mazar
Department of Nephrology, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel
Kidney Int 67:1340-9. 2005CD40 is a member of the tumor necrosis factor (TNF) family of receptors whose ligand (CD154) is found mainly on membranes of activated mononuclear cells...
- The CD154-CD40 T-cell co-stimulation pathway in liver ischemia and reperfusion inflammatory responsesBibo Ke
The Dumont University of California, Los Angeles Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Transplantation 79:1078-83. 2005..The precise contribution of T cells in the mechanism of I/R injury remains to be elucidated. As the CD154-CD40 co-stimulation pathway provides essential second signal in the initiation and maintenance of T-cell-dependent ..
- CD4+ T lymphocytes expressing CD40 ligand help the IgM antibody response to soluble pneumococcal polysaccharides via an intermediate cell typeAxel Jeurissen
Laboratory of Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Catholic University, Leuven Belgium
J Immunol 176:529-36. 2006..We previously showed that the murine Ab response to caps-PS is dependent on CD40-CD40L interaction...
- FK506 controls CD40L-induced systemic autoimmunity in miceKarin Loser
Department of Dermatology, University of Munster, Munster, Germany
J Invest Dermatol 126:1307-15. 2006..Autoimmune disorders play an increasingly important role and CD40-CD40 ligand (CD40L) interaction on immunocompentent cells is able to break established immunotolerance...
- Costimulatory blockade of CD154-CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitizationHong Xu
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY 40202 1760, USA
Blood 111:3266-75. 2008Sensitization is a critical unresolved challenge in transplantation. We show for the first time that blockade of CD154 alone or combined with T-cell depletion prevents sensitization...
- Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their developmentPhilip J Spence
Department of Pathology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
Proc Natl Acad Sci U S A 105:973-8. 2008..We report the critical requirement for CD154 up-regulation specifically on, and during the thymic development of, Foxp3(+) regulatory T cells for the induction ..
- ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reactionFrances Vu
Department of Immunology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
J Immunol 180:2284-93. 2008..Signaling through ICOS has multiple consequences, including cytokine production, expression of CD40L on Th cells, and differentiation into CXCR5(+) follicular Th cells, all of which are important in the GC reaction...
- Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cellsMichael G Strainic
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Immunity 28:425-35. 2008..G protein-coupled receptors (GPCRs), C5aR and C3aR, on APCs and T cells both upstream and downstream of CD28 and CD40L signaling are integrally involved in T cell proliferation and differentiation...
- Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient miceBeatriz Hernandez-Novoa
Critical Care Medicine Department, National Institutes of Health Clinical Center, NIH, Building 10, Room 2C145, MSC 1662, Bethesda, MD 20892 1662, USA
J Leukoc Biol 84:420-30. 2008..Microarray methods were used to examine differential gene expression in the lungs of C57BL/6 and CD40 ligand knockout (CD40L-KO) mice over time following exposure to Pneumocystis murina...
- Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregationGuo Min Deng
Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
J Immunol 181:4019-26. 2008..Our results demonstrate that lipid rafts contribute significantly to the pathogenesis of lupus and provide a novel mechanism whereby aggregated lipid rafts represent a potential link between infection and autoimmunity...
- CD40 expression levels modulate regulatory T cells in Leishmania donovani infectionSunil Martin
National Centre for Cell Science, Ganeshkhind, Pune, India
J Immunol 185:551-9. 2010..We demonstrate that the knowledge can be efficiently used in adoptive cell transfer therapy against an infectious disease...
- Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black miceEvelyn Pau
Arthritis Centre of Excellence, Toronto Western Research Institute, Toronto, Ontario, Canada
Clin Immunol 139:215-27. 2011New Zealand Black (NZB) mice spontaneously develop a lupus-like autoimmune disease. Since CD40-CD40L interactions are important for B cell class-switch recombination and germinal center formation, we sought to understand the impact of ..
- Inhibition of the CD40-CD40ligand pathway prevents murine membranous glomerulonephritisL Biancone
Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, USA
Kidney Int 48:458-68. 1995..production requires T cell costimulatory signals provided in part by T cell surface expression of gp39/CD40ligand (CD40L) that engages the B cell receptor CD40 and induces B cell differentiation and immunoglobulin class switching...
- A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factorsM C Peitsch
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
Int Immunol 5:233-8. 1993Based on the similarity in primary structure between the newly characterized ligand for CD40 (CD40L) and the tumor necrosis factors (TNFs), we have modeled a detailed 3-D structure for CD40L...
- Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factorR G Goodwin
Immunex Research and Development Corporation, Seattle, Washington 98101
Cell 73:447-56. 1993..Biological characterization indicates that the cloned ligand induces the proliferation of costimulated T cells and enhances the generation of cytolytic T cells...
- IMMUNOTOXICOLOGY OF A HEAVY METALKenneth Pollard; Fiscal Year: 2004..Analysis of the interaction between fibrillarin, mercury and cells of the lymphoid system may lead to insights into how an imunotoxin renders self-antigen immunogenic. ..
- BECTON DICKINSON FACS CALIBUR 4 COLOR WITH SORT UNITKenneth Pollard; Fiscal Year: 2001..Flow cytometry will be used to select and sort cell populations prior to and after transplantation studies. ..
- Regulation of HIV-1 Preintegration Complexes (PICs)RICHARD KORNBLUTH; Fiscal Year: 2002..New tools and concepts will be gained, and precise molecular targets for anti-HIV drug design will come into focus. ..
- XENOBIOTIC ACCELERATION OF AUTOIMMUNITYKenneth Pollard; Fiscal Year: 2003..abstract_text> ..
- LOCI AFFECTING HYBRID STERILITY IN MICERosemary Elliott; Fiscal Year: 2003..The loci on proximal Chr X and their suppressors may play significant roles in causing sterility in the human male. They are also probably involved in early stages of speciation. ..
- TNFSF APC activators for HIV VaccinesRICHARD KORNBLUTH; Fiscal Year: 2003..In contrast, normal immune responses rely upon endogenous activators of APCs, mainly CD40 ligand (CD40L, also called CD154 or TNFSF5)...
- Protective role of cross-reactive anti-enteric antibodyLynn Bry; Fiscal Year: 2005..which mice naive to infection generate an antibody response, (2) develop monoclonal mucosal (IgA) and serum (IgG or IgM) antibodies against these antigens and assess the ability of administered immunoglobulin to impact colonization and ..
- Combined TNFSF and TLR stimulation of HIV vaccinesRICHARD KORNBLUTH; Fiscal Year: 2006..Experiments are described that show that plasmid DNA for a new soluble, multimeric form of CD40L is an effective adjuvant for DNA vaccines in mouse models, and it will be important to test other ..
- Role of T cells in self-limited mucosal infectionsLynn Bry; Fiscal Year: 2006..However, immunocompetent mice develop an early and robust serum IgM response and have few colony forming units (CFU) in end organs including liver and spleen...
- Chronic rejection in a transgenic mouse modelStephen Huddleston; Fiscal Year: 2006..This system will provide a broadly applicable tool for further investigation of the role of costimulation and antigen presentation in chronic rejection and for studies of tolerance. [unreadable] [unreadable]..
- MERCURY INDUCED AUTOIMMUNITYKenneth Pollard; Fiscal Year: 2007..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
- Loci Affecting Colon Cancer SusceptibilityRosemary Elliott; Fiscal Year: 2008..In the third aim we will address the question of what genetic changes occur in the tumors themselves, and whether there is specificity such that tumors arising from any one of the congenic strains show a consistent profile of changes. ..
- Vaccines to Generate Neutralizing Anti-HIV AntibodiesRICHARD KORNBLUTH; Fiscal Year: 2008..Aim 3 will test the adjuvant effects of CD40L, GITRL, BAFF, and APRIL, four TNF superfamily ligands, on the antibody responses to the DNA vaccines of Aim 1...
- Crimson - i2b2 integration for high-throughput, scalable sample collectionLynn Bry; Fiscal Year: 2010....