Genomes and Genes
Gene Symbol: Cd40
Description: CD40 antigen
Alias: AI326936, Bp50, GP39, HIGM1, IGM, IMD3, T-BAM, TRAP, Tnfrsf5, p50, tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, CD40L receptor, T-cell differentiation antigen
Publications135 found, 100 shown here
- Reduction of atherosclerosis in mice by inhibition of CD40 signallingF Mach
Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 394:200-3. 1998..in human atherosclerotic lesions express the immune mediator CD40 and its ligand CD40L (also known as CD154 or gp39). The interaction of CD40 with CD40L figures prominently in both humoral and cell-mediated immune responses...
- Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in miceJonathan C Poe
Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 6:e22464. 2011Aberrant CD40 ligand (CD154) expression occurs on both T cells and B cells in human lupus patients, which is suggested to enhance B cell CD40 signaling and play a role in disease pathogenesis...
- Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infectionL Soong
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
Immunity 4:263-73. 1996To study the role of CD40 ligand (CD40L) in the host immune responses against intracellular pathogens, we infected CD40L knockout (CD40L-/-) mice with Leishmania amazonensis...
- Systemic administration of antigen-loaded CD40-deficient dendritic cells mimics soluble antigen administrationKristin Hochweller
ICAPB, University of Edinburgh, Edinburgh, GB
Eur J Immunol 34:990-8. 2004..We show here that CD40 plays an important rolein this decision...
- Levels of CD40 expression on dendritic cells dictate tumour growth or regressionG Murugaiyan
National Centre for Cell Science, Ganeshkhind, Pune, India
Clin Exp Immunol 149:194-202. 2007Tumour regression requires activation of T cells. It has been shown that the interaction between T cell-expressed CD40-ligand (CD40-L) and antigen-presenting cell-expressed CD40 plays a crucial role in T cell activation...
- Inhibition of allergic responses by CD40 gene silencingM Suzuki
Department of Surgery, University of Western Ontario, London, ON, Canada
Allergy 64:387-97. 2009..The aim of this study was to evaluate therapeutic effects of CD40 siRNA on inhibition of allergic responses.
- Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosisDirk Lievens
Department of Pathology, Maastricht Center for Atherosclerosis Research, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Blood 116:4317-27. 2010b>CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic and inflammatory contributions of platelet CD40L in atherosclerosis...
- B cell receptor (BCR) cross-talk: CD40 engagement enhances BCR-induced ERK activationTakuya Mizuno
Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
J Immunol 174:3369-76. 2005Bystander B cells may be initially stimulated through CD40, which enhances susceptibility to Fas-mediated apoptosis, before encountering Ag, which produces Fas resistance...
- A costimulatory function for T cell CD40Melissa E Munroe
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 178:671-82. 2007b>CD40 plays a significant role in the pathogenesis of inflammation and autoimmunity. B cell CD40 directly activates cells, which can result in autoantibody production...
- Involvement of CRAF1, a relative of TRAF, in CD40 signalingG Cheng
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Science 267:1494-8. 1995b>CD40 is a receptor on the surface of B lymphocytes, the activation of which leads to B cell survival, growth, and differentiation...
- Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signalsTeruhito Yasui
Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
Int Immunol 14:319-29. 2002b>CD40 is essential for efficient humoral immune responses. CD40 has two cytoplasmic domains required for binding of tumor necrosis factor receptor-associated factors (TRAF)...
- The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cellsCory Ahonen
Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
Nat Immunol 3:451-6. 2002..maturation of the immune response and the generation of long-lived bone marrow (BM) plasma cells are hallmarks of CD40-dependent, thymus-dependent (TD) humoral immunity...
- Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signalingBruce S Hostager
Department of Pediatrics, Interdisciplinary Program in Immunology, University of Iowa, Iowa City 52242, USA
J Biol Chem 278:45382-90. 2003b>CD40 function is initiated by tumor necrosis factor (TNF) receptor-associated factor (TRAF) adapter proteins, which play important roles in signaling by numerous receptors...
- CD40 ligation in vivo induces bystander proliferation of memory phenotype CD8 T cellsMarie Koschella
Institute of Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
J Immunol 172:4804-11. 2004Injection of agonistic anti-CD40 Abs into mice has been shown to amplify weak CD8 T cell responses to poorly immunogenic compounds and to convert T cell tolerance to T cell priming...
- Role of tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) in distinct and overlapping CD40 and TNF receptor 2/CD120b-mediated B lymphocyte activationMelissa E Munroe
Department of Microbiology, The University of Iowa and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
J Biol Chem 279:53222-31. 2004..An important TNFR family member for B cell activation is CD40. CD40 signals stimulate B cell TNF-alpha secretion, which subsequently signals via TNFR2 (CD120b) to enhance B cell ..
- CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunityThomas Calzascia
The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada
Proc Natl Acad Sci U S A 105:2999-3004. 2008..of activated autoreactive CD4 T cells can prime and expand endogenous autoreactive CD8 T cells in a CD28- and CD40-dependent manner through the licensing of dendritic cells. Despite this, mice do not develop diabetes...
- Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complexAtsushi Matsuzawa
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Science 321:663-8. 2008..Indeed, CD40, a tumor necrosis factor receptor (TNFR) family member, forms a complex containing adaptor molecules TRAF2 and ..
- The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formationT Kawabe
Institute for Molecular and Cellular Biology, Osaka University, Japan
Immunity 1:167-78. 1994An engagement of CD40 with CD40 ligand (CD40L) expressed on activated T cells is known to provide an essential costimulatory signal to B cells in vitro...
- The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switchingA Rolink
Basel Institute for Immunology, Switzerland
Immunity 5:319-30. 1996..B cells from normal (BDF1) and V(D)J recombinase-deficient (RAG-27) or defective (SCID) mice to be induced by a CD40-specific monoclonal antibody and IL-4 to epsilon H chain gene transcription and to S mu-S epsilon switch ..
- Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic regionT Ishida
Department of Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108, Japan
J Biol Chem 271:28745-8. 1996b>CD40 signalings play crucial roles in B-cell function. To identify molecules which transduce CD40 signalings, we have utilized the yeast two-hybrid system to clone cDNAs encoding proteins that bind the cytoplasmic tail of CD40...
- TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activationM F Bachmann
Basel Institute for Immunology, CH 4005 Basel, Switzerland
J Exp Med 189:1025-31. 1999b>CD40 ligand (CD40L), a tumor necrosis factor (TNF) family member, plays a critical role in antigen-specific T cell responses in vivo...
- Cutting edge: contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiationB S Hostager
Department of Microbiology, University of Iowa, VA Medical Center, Iowa City 52242, USA
J Immunol 162:6307-11. 1999In B lymphocytes, CD40 signals contribute to the activation of Ab secretion, isotype switching, T cell costimulation, and immunological memory...
- A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune systemM Tomura
Biomedical Research Center, Osaka University Medical School, Japan
J Immunol 163:93-101. 1999..This study demonstrates that Ag-activated CD4+ NKT cells express CD40 ligand (CD40L) (CD154), which engages CD40 on APC and stimulates them to produce IL-12...
- Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 developmentJ Skok
Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
J Immunol 163:4284-91. 1999..This capacity is dependent on CD40 as B cells from CD40-/- mice do not elicit Th2 differentiation...
- CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytesZ Lu
Johns Hopkins University School of Medicine Oncology Center, Baltimore, Maryland 21231, USA
J Exp Med 191:541-50. 2000..shown that a dominant pathway of CD4(+) help is via antigen-presenting cell (APC) activation through engagement of CD40 by CD40 ligand on CD4(+) T cells...
- Dendritic cell-B-cell interaction: dendritic cells provide B cells with CD40-independent proliferation signals and CD40-dependent survival signalsM Wykes
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
Immunology 100:1-3. 2000..In this study, using B cells and DC from wild type (WT) and CD40 knockout (CD40KO) mice we show that DC initiate proliferation of B cells independently of CD40, because WT or ..
- Involvement of STAT-1 and ets family members in interferon-gamma induction of CD40 transcription in microglia/macrophagesV T Nguyen
Department of Cell Biology, The Univeristy of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
J Biol Chem 275:23674-84. 2000..We have previously shown that the cytokine interferon (IFN)-gamma induces CD40 expression in microglia...
- CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodesA M Moodycliffe
Department of Immunology 178, M D Anderson Cancer Center, Houston, TX 77030, USA
J Exp Med 191:2011-20. 2000Whereas CD40-CD40 ligand interactions are important for various dendritic cell (DC) functions in vitro, their in vivo relevance is unknown...
- Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell developmentA Kumanogoh
Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Japan
J Immunol 166:353-60. 2001Mutations in the CD40 ligand (CD40L) gene lead to X-linked immunodeficiency with hyper-IgM, which is often associated with autoimmune diseases...
- Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophagesVince T Nguyen
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 277:13796-803. 2002b>CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 expression on antigen-presenting cells (including macrophages and microglia) is crucial for T-cell activation...
- CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanismPatrick Andre
The Center for Blood Research, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 8:247-52. 2002..a member of the tumor necrosis factor family of ligands, plays a major role in immune responses via its receptor, CD40. Recently, CD40L has been detected on the surfaces of activated platelets and shown to activate endothelium...
- Short-circuiting long-lived humoral immunity by the heightened engagement of CD40Loren D Erickson
Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Clin Invest 109:613-20. 2002Agonistic alpha CD40 Ab's have been shown to be potent immune adjuvants for both cell- and humoral-mediated immunity...
- The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12Byung O Lee
Trudeau Institute, Saranac Lake, NY 12983, USA
J Exp Med 196:693-704. 2002b>CD40 ligand (CD154) expression on activated T cells can be separated into an early TCR-dependent phase, which occurs between 0 and 24 h after activation, and a later extended phase, which occurs after 24 h and is reciprocally regulated by ..
- A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memoryChristine Bourgeois
INSERM U345, Institut Necker, 156 rue de Vaugirard, F 75730 Paris Cedex 15, France
Science 297:2060-3. 2002The delivery of CD4 help to CD8+ T cell responses requires interactions between CD40 and CD40 ligand and is thought to occur through antigen-presenting cell (APC) activation...
- CD40 regulates the processing of NF-kappaB2 p100 to p52H J Coope
Divisions of Immune Cell Biology and Yeast Genetics, National Institute for Medical Research, London NW7 1AA, UK
EMBO J 21:5375-85. 2002..Ligands which stimulate p100 processing to p52 have not been defined. Here, ligation of CD40 on transfected 293 cells is shown to trigger p52 production by stimulating p100 ubiquitylation and subsequent ..
- CD40-mediated apoptosis in murine B-lymphoma lines containing mutated p53Annette C Hollmann
Neuroimmunology Unit, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, H3A 2B4, Canada
Exp Cell Res 280:201-11. 2002Crosslinking CD40 induces normal B-cells to proliferate and differentiate but causes many tumor cell lines to undergo apoptosis...
- Differential requirements for expression of CD80/86 and CD40 on B cells for T-dependent antibody responses in vivoJoanne M Lumsden
Experimental Immunology Branch, National Cancer Institute, and National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 170:781-7. 2003The CD80/86-CD28 and CD40-CD40 ligand costimulatory pathways are essential for Th cell-dependent B cell responses that generate high-affinity, class-switched Ab in vivo...
- T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activationSimon Fillatreau
Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
J Exp Med 197:195-206. 2003..Migration relies on CD40-dependent maturation of DCs, as it did not occur in CD40-deficient mice but was reconstituted with CD40(+) DCs...
- Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the peripheryGisela M Vaitaitis
Department of Medicine and Webb Waring Institute for Cancer, Aging and Antioxidant Research, University of Colorado, Denver, CO 80262, USA
J Immunol 170:3455-9. 2003..However, this remains controversial. We have suggested that CD40 expression identifies autoaggressive T cells in the periphery of autoimmune prone mice...
- CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infectionVanja Lazarevic
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Immunity 19:823-35. 2003b>CD40(-/-) mice succumbed to low-dose aerosol infection with M. tuberculosis due to deficient IL-12 production leading to impaired priming of IFN-gamma T cell responses. In contrast, CD40L(-/-) mice were resistant to M. tuberculosis...
- Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytesPing Xie
Department of Microbiology, University of Iowa, Iowa City 52242, USA
J Exp Med 199:661-71. 2004b>CD40, a member of the tumor necrosis factor receptor family, and the Epstein-Barr virus-encoded oncoprotein latent membrane protein 1 (LMP1) share several tumor necrosis factor receptor-associated factor (TRAF) adaptor proteins for ..
- Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responsesRam Kumar Mathur
National Centre for Cell Science, Ganeshkhind, Pune 411007, India
Nat Med 10:540-4. 2004..Macrophage-expressed CD40, a costimulatory molecule, induces interleukin-12 (IL-12)-dependent and interferon-gamma (IFN-gamma)-dependent host-..
- Ectopic CD40 ligand expression on B cells triggers intestinal inflammationTakahiro Kawamura
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
J Immunol 172:6388-97. 2004..study we present evidence that B cells can trigger intestinal inflammation using transgenic (Tg) mice expressing CD40 ligand (CD40L) ectopically on B cells (CD40L/B Tg)...
- CD40/CD40L interaction regulates CD4+CD25+ T reg homeostasis through dendritic cell-produced IL-2Cristiana Guiducci
Immunotherapy and Gene Therapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
Eur J Immunol 35:557-67. 2005..Treatment of wt mice with Ab blocking CD40/CD40L interaction results in a fast decrease in T reg number that rapidly recovers upon Ab withdrawal...
- CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediatesRosa M Andrade
Department of Internal Medicine, University of Cincinnati College of Medicine, P O Box 670560, Cincinnati, OH 45267 0560, USA
Infect Immun 73:3115-23. 2005..Using Toxoplasma gondii as a model, we investigated if CD40 signaling generates mouse macrophages with effector function against an intracellular pathogen despite the absence ..
- LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microgliaHongwei Qin
Department of Cell Biology, 1918 University Blvd, MCLM 395, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
Blood 106:3114-22. 2005b>CD40 is expressed on various immune cells, including macrophages and microglia. Aberrant expression of CD40 is associated with autoimmune inflammatory diseases such as multiple sclerosis and rheumatoid arthritis...
- Differential expression and regulation of murine CD40 in regional vascular bedsThorsten Vowinkel
Dept of Molecular and Cellular Physiology, LSU Health Sciences Ctr, 1501 Kings Hwy, Shreveport, LA 71130 3932, USA
Am J Physiol Heart Circ Physiol 290:H631-9. 2006There is emerging evidence for a role of the CD40/CD40 ligand (CD40L) dyad as a signaling mechanism in different inflammatory conditions...
- TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alphaRosa M Andrade
Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Immunol 175:6014-21. 2005..Engagement of CD40 modulates antimicrobial activity in macrophages...
- Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signalingPing Xie
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 176:5388-400. 2006..a new method for gene targeting by homologous recombination in somatic cells, we produced and studied signaling by CD40 and its viral oncogenic mimic, latent membrane protein 1 (LMP1) in mouse B cell lines lacking TRAF1, TRAF2, or both ..
- CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomesRosa M Andrade
Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Clin Invest 116:2366-77. 2006..We report that CD40 stimulation of human and mouse macrophages infected with T...
- Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signalsAndre Boonstra
Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
J Immunol 177:7551-8. 2006..Toll/IL-1 receptor domain-containing adaptor-dependent TLR signals (TLR3, 4 ligation) as well as non-TLR signals (CD40 ligation) induced macrophages and myeloid DC to produce IL-10 in addition to proinflammatory cytokines...
- CD40-CD40 ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colonThorsten Vowinkel
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
Gastroenterology 132:955-65. 2007Although the CD40-CD40 ligand (CD40L) signaling pathway has been implicated in the pathogenesis of a variety of diseases, including inflammatory bowel disease, the nature of its contribution to intestinal inflammation remains poorly ..
- The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiationLi Fan Lu
Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
Blood 110:193-200. 2007The recruitment of tumor necrosis factor receptor-associated factors (TRAFs) 1, 2, 3, 5, and 6 to the CD40 cytoplasmic tail upon CD40 trimerization results in downstream signaling events that ultimately lead to CD40-dependent, thymus-..
- CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1Andreas Zirlik
Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 115:1571-80. 2007Strong evidence supports a role for CD40 ligand (CD40L) as marker and mediator of inflammatory diseases such as atherosclerosis...
- The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodelingMarjo M P C Donners
Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
Blood 111:4596-604. 2008We investigated the role of CD40 and CD40L in neointima formation and identified the downstream CD40-signaling intermediates (tumor necrosis factor [TNF]-receptor associated factors [TRAF]) involved...
- Novel vaccination for allergy through gene silencing of CD40 using small interfering RNAMotohiko Suzuki
Department of Surgery, University of Western Ontario, London, ON, Canada
J Immunol 180:8461-9. 2008..In this study, we report a novel therapy for allergy through gene silencing of CD40, a critical costimulatory molecule and a key factor in allergic immune responses...
- CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 productionKok Loon Wong
Immunology Program and Department of Microbiology, Centre for Life Sciences, National University of Singapore, Singapore
Eur J Immunol 38:2251-62. 2008..Our results suggest that the interaction between CD8alpha(+) DC and antigen-primed CD8 T cells may form an important component of Th1-mediated immunity through the induction of IL-12p70...
- Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lambliaJoel Désiré Kamda
Department of Biology, Reiss 406, Georgetown University, Washington, DC 20057, USA
Infect Immun 77:685-93. 2009..DCs incubated with live parasites or parasite extracts displayed enhanced levels of CD40. The expression of CD80 and CD86 also increased, but less than was seen with lipopolysaccharide-activated DCs...
- CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cellsGiandomenica Iezzi
Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
Proc Natl Acad Sci U S A 106:876-81. 2009..and in vitro systems, we have investigated the role of antigen dose, pathogen-associated molecular patterns, and CD40-CD40 ligand (CD40L) cross-talk in Th17 differentiation...
- Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60Su Jeong Ryu
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
Blood 113:4273-80. 2009..Adoptively transferred memory CD8 T cells did not proliferate in CD40L(-/-) hosts. In the CD40(-/-) hosts, marginal memory expansion was detected after priming with male H60 cells but was completely abolished ..
- A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivoGeorgia Perona-Wright
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom
J Immunol 182:2808-15. 2009The costimulatory requirements for Th17 development remain to be defined. In this study, we show that CD40-deficient animals immunized with the gram-positive bacterium Propionibacterium acnes were specifically impaired in their ability to ..
- The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signalsKoichi Yanaba
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 182:7459-72. 2009..However, prolonged LPS or CD40 stimulation (48 h) induced additional adult spleen CD1d(high)CD5(+) B cells to express IL-10 following PMA plus ..
- Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profileEsther Lutgens
Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht 6200 MD, Netherlands
J Exp Med 207:391-404. 2010The CD40-CD40 ligand (CD40L) signaling axis plays an important role in immunological pathways. Consequently, this dyad is involved in chronic inflammatory diseases, including atherosclerosis...
- Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areasAnna Bolduc
Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912, USA
J Immunol 185:220-30. 2010b>CD40/CD40L engagement is essential to T cell-dependent B cell proliferation and differentiation...
- Augmented antibody response with premature germinal center regression in CD40L transgenic miceYusuke Kishi
Laboratory of Immunology, Graduate School of Biomedical Sciences, Tokyo Medical and Dental University, Tokyo, Japan
J Immunol 185:211-9. 2010Although CD40 signaling is required for activation and differentiation of B cells, including germinal center (GC) formation and generation of memory B cells, in vivo generation of CD40 signaling augments plasma cell differentiation but ..
- HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complexBruce S Hostager
Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
PLoS ONE 5:e11380. 2010..One family member, CD40, is important for the efficient activation of antibody-producing B cells and other antigen-presenting cells...
- Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signalingElissa K Deenick
Immunology Program, Garvan Institute of Medical Research, Darlinghurst, 2010, NSW, Australia
Immunity 33:241-53. 2010....
- CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infectionNeetu Srivastava
National Centre for Cell Science, Ganeshkhind, Pune 411007, India
J Immunol 186:5863-72. 2011The macrophage-expressed CD40 regulates immune responses to Leishmania major infection by reciprocal signaling through p38 MAPK and ERK1/2. CD40-induced IL-10 or IL-12 plays crucial roles in the promotion or protection from L...
- Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockadeIvana R Ferrer
Emory Transplant Center and Department of Surgery, Emory University, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 108:20701-6. 2011Blockade of the CD40/CD154 pathway potently attenuates T-cell responses in models of autoimmunity, inflammation, and transplantation...
- Reciprocal regulation of protein kinase C isoforms results in differential cellular responsivenessRaki Sudan
National Centre for Cell Science, Ganeshkhind, Pune 411 007, India
J Immunol 188:2328-37. 2012..As CD40 is the only receptor characterized to trigger counteractive functions, we examined the relative role of PKC ..
- Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responsesCraig P Chappell
Department of Immunology, University of Washington, Seattle, WA 98195, USA
J Exp Med 209:1825-40. 2012....
- Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memoryTomohiro Kaji
Laboratory for Immunological Memory, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
J Exp Med 209:2079-97. 2012....
- Monoclonal antibodies to murine CD40 define two distinct functional epitopesA W Heath
DNAX Research Institute, Palo Alto, CA 94304
Eur J Immunol 24:1828-34. 1994Two rat IgG2a antibodies which define distinct epitopes on murine CD40 have been generated...
- Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host diseaseKoji Tamada
Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Invest 109:549-57. 2002..Here, we demonstrate that infusion of an mAb against CD40 ligand (CD40L) further increases the efficacy of LTbetaR-Ig, leading to complete prevention of GVHD...
- Rapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signalingYanlin Zhao
Department of Molecular Microbiology and Immunology, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA
Infect Immun 75:4799-803. 2007..b>CD40 ligation has also been shown to trigger autophagic elimination of T...
- A novel mechanism for TNFR-associated factor 6-dependent CD40 signalingSarah L Rowland
Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80262, USA
J Immunol 179:4645-53. 2007..One member of the family critical for efficient activation of T-dependent humoral immune responses is CD40, a cell surface protein expressed by B cells and other APC...
- A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulationXiufen Zheng
Department of Surgery, University of Western Ontario, London, ON, Canada
Blood 113:2646-54. 2009..Herein, we present a new method of selectively delivering siRNA to dendritic cells (DCs) in vivo using CD40 siRNA-containing immunoliposomes (siILs) that were decorated with DC-specific DEC-205 mAb...
- CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementationE Castigli
Division of Immunology, Children s Hospital, Boston, MA
Proc Natl Acad Sci U S A 91:12135-9. 1994To study the role of B-cell antigen CD40 in immune responses, mouse embryonic stem (ES) cells in which both copies of the gene encoding CD40 had been disrupted by homologous recombination were injected in RAG-2 (recombination-activating ..
- Induction of alloantigen-specific tolerance by B cells from CD40-deficient miceG A Hollander
Division of Pediatric Oncology, Dana Farber Cancer Institute, Havard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 93:4994-8. 1996Interaction between CD40 on B cells and CD40 ligand molecules on T cells is pivotal for the generation of a thymus-dependent antibody response...
- Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune diseaseTetsuya Higuchi
Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
J Immunol 168:9-12. 2002b>CD40 ligand (CD40L) is ectopically expressed on B cells in patients with systemic lupus erythematosus (SLE) and lupus-prone BXSB mice...
- Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120bBruce S Hostager
Department of Microbiology, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
J Immunol 168:3318-22. 2002TNFR-associated factors (TRAFs) participate in the signaling of many TNFR family members, including CD40, CD120a (TNFR1), and CD120b (TNFR2)...
- The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switchingHaifa Jabara
Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Immunity 17:265-76. 2002To define the role of TRAF proteins in CD40-dependent isotype switching in B cells, we introduced wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or ..
- Interleukin-12 is necessary for the priming of CD4+ T cells required during the elicitation of HIV-1 gp120-specific cytotoxic T-lymphocyte functionShalini Gupta
National Centre for Cell Science, Ganeshkhind, Pune, India
Immunology 124:553-61. 2008..Our results also suggest that IL-12 is vital for the priming of antigen-specific T cells and plays an essential role in IFN-gamma induction in T cells...
- Immune modulation through RNA interference-mediated silencing of CD40 in dendritic cellsMohammad Hossein Karimi
Immunology Department, Tarbiat Modares University, Tehran, Iran
Cell Immunol 259:74-81. 2009..Our findings in this study showed that down regulation of CD40 gene expression in dendritic cells (DCs) by RNAi culminated to immune modulation...
- Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTVA V Chervonsky
Section of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, Connecticut 06510, USA
Immunity 3:139-46. 1995The propagation of mouse mammary tumor virus (MMTV) has been analyzed in mice defective for expression of CD40 ligand (CD40L)...
- Inhibition of the CD40-CD40ligand pathway prevents murine membranous glomerulonephritisL Biancone
Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, USA
Kidney Int 48:458-68. 1995..signals provided in part by T cell surface expression of gp39/CD40ligand (CD40L) that engages the B cell receptor CD40 and induces B cell differentiation and immunoglobulin class switching...
- On costimulatory signals and T cell tolerance: relevance for transplantation immunityG A Hollander
Department of Research, Basel University Medical School, Switzerland
Transplant Proc 31:25S-31S. 1999
- Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activationH Nakano
Department of Immunology, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Proc Natl Acad Sci U S A 96:9803-8. 1999..kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor...
- Eradication of Cryptosporidium parvum infection by mice with ovalbumin-specific T cellsK Lukin
Departments of Immunology and Pediatrics and the Barbara Davis Childhood Diabetes Center, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Infect Immun 68:2663-70. 2000..parvum infection. Our data suggest that antigen-nonspecific CD4(+) T-cell effector mechanisms in combination with the innate arm of the immune system are sufficient for the eradication of C. parvum infection...
- Stimulation via CD40 can substitute for CD4 T cell function in preventing reactivation of a latent herpesvirusS R Sarawar
Divisions of Molecular Immunology and Immune Regulation, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 98:6325-9. 2001..In the present study, we used a mouse model of opportunistic infection to determine whether stimulation via CD40 could substitute for CD4 T cell function in preventing reactivation of a latent herpesvirus...
- Critical role for IL-4 in the development of transplant arteriosclerosis in the absence of CD40-CD154 costimulationS M Ensminger
Nuffield Departments of Surgery and Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 167:532-41. 2001Blockade of the CD40-CD154 pathway can inhibit CD4(+) T cell activation but is unable to prevent immune responses mediated by CD8(+) T cells...
- Homeostatic expansion occurs independently of costimulatory signalsM Prlic
Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 167:5664-8. 2001..expansion of CD4 and CD8 T cells occurs independently of costimulation signals mediated through CD28/B7, CD40L/CD40, or 4-1BB/4-1BBL interactions. Using DO11...
- Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunityArno Hänninen
The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia
J Clin Invest 109:261-7. 2002..in mice expressing OVA transgenically in pancreatic beta cells, can be prevented by transiently blocking the CD40 ligand (CD40L)...
- CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotectionXiu Da Shen
Transplantation 74:315-9. 2002..This study was designed to analyze the role of T cells and CD154-CD40 T- cell costimulation pathway in a mouse liver I/R model.
- Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivoJennifer L Matsuda
La Jolla Institute for Allergy and Immunology, and Division of Biological Sciences, University of California, San Diego, CA, USA
Proc Natl Acad Sci U S A 100:8395-400. 2003....
- Blockade of CD40-CD40 ligand protects against renal injury in chronic proteinuric renal diseaseLukas Kairaitis
Department of Renal Medicine, The University of Sydney at Westmead Hospital, Westmead, Sydney, Australia
Kidney Int 64:1265-72. 2003Interaction between CD40 and CD40 ligand (CD40L) is involved in both cognate and innate immune responses. Blockade of CD40-CD40L interactions reduces severity of renal injury in murine lupus nephritis and membranous nephropathy...
- Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40phox, a cytosolic subunit of nicotinamide adenine dinucleotide phosphate oxidaseYun Jung Ha
Division of Molecular Life Sciences and Center for Cell Signaling Research, College of Natural Sciences, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul 120 750, Korea
J Immunol 172:231-9. 2004To extend our previous report, which showed the production of the reactive oxygen species (ROS) after the CD40 ligation in the B cells, we further examined the possible mechanisms for ROS production and the involvement of CD40-induced ROS ..
- Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cellsJoseph C Sun
Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
J Immunol 172:3385-9. 2004..We investigated whether signaling via CD40 expressed on the CD8 cells themselves is involved in this cooperation...
- CD40 is necessary for activation of naïve T cells by a dendritic cell line in vivo but not in vitroC Haase
Hagedorn Research Institute, Gentofte, Denmark
Scand J Immunol 59:237-45. 2004The importance of CD40-CD40L interactions during CD4(+) T-cell activation has been extensively investigated over the years; however, it still remains questionable whether the interaction is a prerequisite for dendritic cell (DC)-mediated ..
- Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sitesJudie Boisvert
Department of Pathology, University of California, San Francisco, CA 94143, USA
J Immunol 173:3647-52. 2004..In this study, we show that the CD40-CD154 receptor-ligand pair is also highly concentrated into a central region of the synapse on mouse lymphocytes ..
- The development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40Megan J Montfort
Department of Molecular Microbiology, Oregon Health and Science University, Portland 97239, USA
J Immunol 173:4084-90. 2004..of CD4 Th cells reportedly have functional defects, and at least a subset of CD8 T cells transiently express CD40 after activation, suggesting that direct CD4-CD8 T cell interactions through CD40 may influence the magnitude and ..
- Using gene targeting to address the role of LRRK2 in Parkinson's diseaseBruce Hostager; Fiscal Year: 2007..This knowledge will aid in the identification of the environmental triggers and additional genetic factors that participate in the development of Parkinson's disease. ..
- Dietary Antioxidants, NF-KappaBeta, and CarcinogenesisHOWARD GLAUERT; Fiscal Year: 2002..The development of a knockout mouse model that is deficient in the p50 subunit of NF-kB will allow the investigators to answer this question...
- CHEMOKINES IN THE IMMUNE RESPONSE TO A VIRAL INFECTIONSally Sarawar; Fiscal Year: 2002..3) The role of the CXCR2 chemokine receptor homologue in viral pathogenesis will be determined using a mutant virus in which the gene encoding the CXCR2 homologue has been inactivated. ..
- MATERNAL IMMUNE TOLERANCE TO THE ALLOGENEIC FETUSAdrian Erlebacher; Fiscal Year: 2003..These experiments will rely upon the ability of activating monoclonal antibodies towards CD40 expressed by antigen presenting cells to substitute for helper cell function in vivo...
- Gene expression in non-functional CD8 T cellsSally Sarawar; Fiscal Year: 2005..Using this mouse model of opportunistic infection, we showed that agonistic antibodies to CD40 could substitute for CD4 T cell function in preventing the reactivation of MHV-68 in CD4 T cell deficient mice...
- Interaction between influenza virus and H. influenzaeSally Sarawar; Fiscal Year: 2007..This could be particularly important during an influenza pandemic and may be more broadly applicable to other respiratory viruses. [unreadable] [unreadable] [unreadable]..
- Prevention of Cigarette Smoke-Induced Lung Cancer by Dietary SeleniumHOWARD GLAUERT; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Immunological control of a persistent viral infectionSally R Sarawar; Fiscal Year: 2010..Our early work highlighted the importance of CD40-CD40L interactions in CD4 T cell help in the long-term control of MHV-68 and showed that CD40 stimulation alone, ..