Cd4

Summary

Gene Symbol: Cd4
Description: CD4 antigen
Alias: L3T4, Ly-4, T-cell surface glycoprotein CD4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)
Species: mouse

Top Publications

  1. ncbi Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment
    R K Leung
    Nuffield Department of Clinical Medicine, University of Oxford, Level 7, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Immunol 2:1167-73. 2001
  2. pmc Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice
    Ramireddy Bommireddy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Cell Immunol 232:96-104. 2004
  3. ncbi CD4 is expressed on murine pluripotent hematopoietic stem cells
    J P Wineman
    Medical Biology Institute, La Jolla, CA 92037
    Blood 80:1717-24. 1992
  4. ncbi Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck
    A Veillette
    Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892
    Nature 338:257-9. 1989
  5. ncbi The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
    A Veillette
    Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892
    Cell 55:301-8. 1988
  6. ncbi Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice
    A Rahemtulla
    Amgen Institute, Toronto, Ontario, Canada
    Eur J Immunol 24:2213-8. 1994
  7. pmc A transcriptional silencer controls the developmental expression of the CD4 gene
    G Siu
    Department of Microbiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032
    EMBO J 13:3570-9. 1994
  8. ncbi Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice
    R M Locksley
    Department of Medicine, University of California, San Francisco 94143 0654
    Science 261:1448-51. 1993
  9. pmc Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4
    N Killeen
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0414
    EMBO J 12:1547-53. 1993
  10. ncbi Role of CD4 and CD8 in T cell activation and differentiation
    M C Miceli
    Department of Medicine, Stanford University School of Medicine, California 94305
    Adv Immunol 53:59-122. 1993

Detail Information

Publications119 found, 100 shown here

  1. ncbi Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment
    R K Leung
    Nuffield Department of Clinical Medicine, University of Oxford, Level 7, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Immunol 2:1167-73. 2001
    The mechanism of T cell lineage commitment remains controversial; to examine it we deleted the CD4-silencer element in the germ line of a mouse using a combination of gene targeting and Cre/LoxP-mediated recombination...
  2. pmc Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice
    Ramireddy Bommireddy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Cell Immunol 232:96-104. 2004
    ..Here, we show that elimination of T but not B cells is sufficient for the reversal, but elimination of either CD4+ or CD8+ cells is not...
  3. ncbi CD4 is expressed on murine pluripotent hematopoietic stem cells
    J P Wineman
    Medical Biology Institute, La Jolla, CA 92037
    Blood 80:1717-24. 1992
    We show here for the first time that pluripotent hematopoietic stem cells express the CD4 antigen...
  4. ncbi Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck
    A Veillette
    Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892
    Nature 338:257-9. 1989
    The CD4 T-cell surface antigen is an integral membrane glycoprotein of relative molecular mass 55,000 which binds class II major histocompatibility complex (MHC) molecules expressed on antigen presenting cells (APCs)...
  5. ncbi The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
    A Veillette
    Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892
    Cell 55:301-8. 1988
    The CD4 and CD8 T cell antigens are thought to transduce an independent signal during the process of T cell activation...
  6. ncbi Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice
    A Rahemtulla
    Amgen Institute, Toronto, Ontario, Canada
    Eur J Immunol 24:2213-8. 1994
    Previously, we and others have demonstrated that CD4-deficient mice have a normal number of T cells and B cells with a significant population of CD4-8-TcR alpha beta+ T cells...
  7. pmc A transcriptional silencer controls the developmental expression of the CD4 gene
    G Siu
    Department of Microbiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032
    EMBO J 13:3570-9. 1994
    The appropriate expression of the CD4 glycoprotein is required for T-cell function and development...
  8. ncbi Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice
    R M Locksley
    Department of Medicine, University of California, San Francisco 94143 0654
    Science 261:1448-51. 1993
    Expression of either the CD4 or CD8 glycoproteins discriminates two functionally distinct lineages of T lymphocytes...
  9. pmc Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4
    N Killeen
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0414
    EMBO J 12:1547-53. 1993
    During T cell development, precursor thymocytes that co-express the CD4 and CD8 glycoproteins give rise to mature progeny expressing one of these molecules to the exclusion of the other...
  10. ncbi Role of CD4 and CD8 in T cell activation and differentiation
    M C Miceli
    Department of Medicine, Stanford University School of Medicine, California 94305
    Adv Immunol 53:59-122. 1993
  11. ncbi CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4
    S K Mendiratta
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Immunity 6:469-77. 1997
    ..NT cells promptly produce large amounts of IL-4, suggesting that these cells can influence the differentiation of CD4+ effector T cell subsets. We have generated mice that carry a mutant CD1d1 gene...
  12. pmc Disruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4(+) T cells in vivo
    J M Riberdy
    Department of Immunology, Box 3010, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:4493-8. 1998
    The experiments presented in this report were designed to specifically examine the role of CD4-major histocompatibility complex (MHC) class II interactions during T cell development in vivo...
  13. ncbi CD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR
    D Leitenberg
    Howard Hughes Medical Institute, Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 161:1194-203. 1998
    To define the role of CD4 in modulating T cell signaling pathways and regulating Th1 and Th2 differentiation, we have examined the activation and differentiation characteristics of naive T cells from CD4 mutant mice...
  14. ncbi Negative regulation of CD4 lineage development and responses by CD5
    C Pena-Rossi
    Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    J Immunol 163:6494-501. 1999
    ..Here we show that the development and responses of CD4 lineage T cells are regulated by the function of CD5. Thymocytes expressing the I-Ad-restricted DO11...
  15. ncbi Requirement for RORgamma in thymocyte survival and lymphoid organ development
    Z Sun
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
    Science 288:2369-73. 2000
    ..RORgamma thus regulates the survival of CD4+8+ thymocytes and may control the temporal window during which thymocytes can undergo positive selection...
  16. ncbi CD4(+) v(alpha)14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major
    H Ishikawa
    Department of Parasitology and Immunology, University of Tokushima School of Medicine, 3 18 Kuramoto, Tokusima 770 8503, Japan
    Int Immunol 12:1267-74. 2000
    ..In those resistant mice, CD4(+) NKT cells prominently increased in their regional lymph node and were the main effector cells at least for an ..
  17. ncbi Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage
    Y R Zou
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Genet 29:332-6. 2001
    The process of thymocyte development culminates in the maturation of helper (CD4+) and cytotoxic (CD8+) T cells from their common precursors, the CD4+CD8+ double-positive cells...
  18. pmc Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene
    Q Wang
    Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143 0414, USA
    J Exp Med 194:1721-30. 2001
    Absence of CD4 impairs the efficiency of T cell receptor (TCR) signaling in response to major histocompatibility complex (MHC) class II-presented peptides...
  19. ncbi Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    Tian H Chi
    Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 418:195-9. 2002
    Thymic development produces two sub-lineages of T cells expressing either CD4 or CD8 co-receptors that assist antibody production and mediate cell killing, respectively...
  20. ncbi CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    Thomas R Malek
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101, USA
    Immunity 17:167-78. 2002
    ..Here, we show that CD4(+)CD25(+) regulatory T cells were not readily detected in IL-2Rbeta(-/-) mice, but the production of functional CD4(..
  21. ncbi Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 111:621-33. 2002
    T lymphocytes differentiate in discrete stages within the thymus. Immature thymocytes lacking CD4 and CD8 coreceptors differentiate into double-positive cells (CD4(+)CD8(+)), which are selected to become either CD4(+)CD8(-)helper cells ..
  22. ncbi Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection
    Devon J Shedlock
    Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Immunol 170:2053-63. 2003
    b>CD4 T cells are known to assist the CD8 T cell response by activating APC via CD40-CD40 ligand (L) interactions...
  23. ncbi Hierarchical interactions control CD4 gene expression during thymocyte development
    Matthew Adlam
    Department of Microbiology, 701 West 168th Street, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Immunity 18:173-84. 2003
    b>CD4 gene regulation provides an ideal model for understanding the molecular events that drive T cell development...
  24. ncbi Deletion of beta-catenin impairs T cell development
    Youyuan Xu
    Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1177-82. 2003
    ..In addition, beta-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T cells. These data indicate that beta-catenin-mediated signals are required for normal T cell development...
  25. ncbi An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
    ..This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues...
  26. ncbi Key roles of CD4+ T cells and IFN-gamma in the development of abdominal aortic aneurysms in a murine model
    Wanfen Xiong
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 172:2607-12. 2004
    ..However, the role of CD4(+) T cells, the most abundant infiltrates in aneurysmal aortic tissue, is uncertain...
  27. pmc The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells
    Aaron J Tyznik
    Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    J Exp Med 199:559-65. 2004
    In experiments to study the impact of deficiency in CD4+ T cell help on the magnitude of CD8+ cytotoxic T cell response to pathogens, it was noted that in CD4 gene knockout mice, the CD8 population made significant responses to several ..
  28. ncbi Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections
    Michael J Fuller
    Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 172:4204-14. 2004
    ..b>CD4-deficient mice cannot control infection with certain strains of LCMV, but do mount multi-epitope-specific CD8 T ..
  29. ncbi Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity
    Sophia D Sarafova
    Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Immunity 23:75-87. 2005
    ..More importantly, by placing CD4 protein expression under the control of CD8 transcriptional regulatory elements, we demonstrate that cessation of ..
  30. pmc Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis
    Frank Leithäuser
    Department of Pathology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Am J Pathol 168:1898-909. 2006
    ..Therefore, we analyzed the putative function of large intestinal dendritic cell (DC) aggregates, to which donor CD4+ T cells selectively home before colitis becomes manifest...
  31. pmc Dysregulation of IL-15-mediated T-cell homeostasis in TGF-beta dominant-negative receptor transgenic mice
    Philip J Lucas
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, CRC 3 3288, 10 Center Drive, Bethesda, MD 20892, USA
    Blood 108:2789-95. 2006
    T-cell subpopulations, defined by their expression of CD4, CD8, naive, and memory cell-surface markers, occupy distinct homeostatic compartments that are regulated primarily by cytokines...
  32. ncbi Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor
    Julien C Marie
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Immunity 25:441-54. 2006
    ..Peripheral CD4+ and CD8+ T cells with TGF-beta-receptor II (TGF-betaRII) deficiency activated cytolytic and T helper 1 (Th1) ..
  33. ncbi Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis
    Henrique Veiga-Fernandes
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 446:547-51. 2007
    ..We further show that a CD45+CD4-CD3-Il7Ralpha-c-Kit+CD11c+ haematopoietic population expressing lymphotoxin has an important role in the formation ..
  34. ncbi Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells
    Dominik Meier
    Division of Developmental Immunology, Center for Biomedicine, Department of Clinical and Biological Sciences DKBW, University of Basel, CH 4058 Basel, Switzerland
    Immunity 26:643-54. 2007
    Development of Peyer's patches and lymph nodes requires the interaction between CD4+ CD3- IL-7Ralpha+ lymphoid-tissue inducer (LTi) and VCAM-1+ organizer cells...
  35. ncbi The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer
    Kathryn F Wildt
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:4405-14. 2007
    The persistence of CD4 expression is a key event distinguishing the differentiation of MHC class II-restricted thymocytes into CD4 T cells from that of MHC class I-restricted thymocytes into CD8 T cells...
  36. pmc Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia
    Mitchell H Grayson
    Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Exp Med 204:2759-69. 2007
    ..FceRIa(-/-) mice had decreased CCL28 and recruitment of IL-13-producing CD4(+) T cells to the lung after viral infection...
  37. pmc Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes
    Olivier Joffre
    Institut National de la Sante et de la Recherche Medicale, U563, Tolerance and Autoimmunity section, Toulouse, F 31300 France
    Nat Med 14:88-92. 2008
    ..Here we show that in mice treated with clinically acceptable levels of irradiation, regulatory CD4+CD25+Foxp3+ T cells stimulated in vitro with alloantigens induced long-term tolerance to bone marrow and subsequent ..
  38. pmc Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development
    Ming Yu
    Department of Immunobiology, Yale University Medical School, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 105:3873-8. 2008
    The CD4 gene is regulated in a stage-specific manner during T cell development, being repressed in CD4(-)CD8(-) double-negative (DN) and CD8 cells, but expressed in CD4(+)CD8(+) double-positive (DP) and CD4 cells...
  39. doi CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus
    Xi He
    Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
    Immunity 28:346-58. 2008
    The transcription factor ThPOK is necessary and sufficient to trigger adoption of the CD4 lymphocyte fate. Here we investigate the regulation of ThPOK expression and its subsequent control of CD4+ T cell commitment...
  40. doi Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner
    Mark F R Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Leukoc Biol 84:152-61. 2008
    ..The postnatal development of the splenic white pulp, involving the influx of T cells, depends on LTalpha1beta2 expressed by B cells...
  41. pmc Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Nat Immunol 9:1122-30. 2008
    The transcription factors GATA-3 and ThPOK are required for intrathymic differentiation of CD4(+) T cells, but their precise functions in this process remain unclear...
  42. doi Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
    Sawako Muroi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Nat Immunol 9:1113-21. 2008
    b>CD4 and the transcription factor ThPOK are essential for the differentiation of major histocompatibility complex class II-restricted thymocytes into the helper T cell lineage; their genes (Cd4 and Zbtb7b (called 'ThPOK' here)) are ..
  43. pmc LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen
    Mark F Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Immunol 182:5439-45. 2009
    ..Furthermore, the same signals may regulate lymphangiogenesis to the lymph node through induction of VEGF-C...
  44. pmc Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice
    Sophia D Sarafova
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Immunity 31:480-90. 2009
    ..cessation of T cell receptor (TCR) signaling during positive selection, with persistent TCR signaling required for CD4 lineage choice...
  45. pmc Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells
    Mark M W Chong
    The Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 24:659-69. 2010
    ..memory during lineage diversification, we employed targeted mutation of a positive-acting cis element in the Cd4 locus to determine the impact on CD4 expression and the differentiation of CD4(+) helper T cells in mice...
  46. pmc Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels
    Kathryn J Mackerness
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:3643-51. 2010
    ..Thus, posttranscription regulatory mechanisms likely disable this effector module...
  47. pmc IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection
    John S Yi
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:4835-45. 2010
    b>CD4 T cells are principal producers of IL-21 and are often required for optimal CD8 T cell responses...
  48. ncbi Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4
    A Rahemtulla
    Department of Medical Biophysics and Immunology, University of Toronto, Ontario, Canada
    Nature 353:180-4. 1991
    ..They also express two key surface coreceptors, CD4 and CD8, which are involved in the interaction with their ligands...
  49. pmc CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge
    M G von Herrath
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 70:1072-9. 1996
    Although primary antiviral CD8+ cytotoxic T lymphocytes (CTL) can be induced in mice depleted of CD4+ T cells, the role of CD4+ T lymphocytes in the generation and maintenance of antiviral memory CTL is uncertain...
  50. ncbi MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
    E O Matechak
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0420, USA
    Immunity 4:337-47. 1996
    The generation of mature CD4 T cells from CD4+CD8+ precursor thymocytes usually requires corecognition of class II MHC by a TCR and CD4, while the production of mature CD8 T cells requires corecognition of class I MHC by a TCR and CD8...
  51. ncbi CD4 promotes breadth in the TCR repertoire
    Q Wang
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 167:4311-20. 2001
    A diverse population of MHC class II-restricted CD4 lineage T cells develops in mice that lack expression of the CD4 molecule...
  52. ncbi Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Mol Cell 10:1083-96. 2002
    An intronic silencer within the CD4 gene is the critical cis regulatory element for T cell subset-specific expression of CD4...
  53. pmc T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells
    Linda Fahlén
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
    J Exp Med 201:737-46. 2005
    b>CD4(+)CD25(+) regulatory T (T reg) cells play a pivotal role in control of the immune response...
  54. ncbi Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes
    Takehito Sato
    Department of Immunology, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259 1193, Japan
    Immunity 22:317-28. 2005
    To understand how CD8 expression is regulated during the transition process from CD4+8+ (CD4 and CD8 double positive, DP) to CD4-8+ (CD8 single positive, CD8SP) cells in the thymus, the involvement of Runx proteins in the alteration of ..
  55. ncbi Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7
    Regis Peffault De Latour
    Unité INSERM U 668, Unité du Développement des Lymphocytes, Institut Pasteur, Paris, France
    Blood 108:2300-6. 2006
    ..of disease was due to the fact that IL-7 is dispensable for the ontogeny, function, and homeostasis of regulatory CD4+ T cells...
  56. ncbi 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
    Jung Hyun Park
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 8:1049-59. 2007
    ..This dynamic interplay induces individual CD8+ T cells to express CD8 in quantities appropriate for the self-specificity of their TCR, promoting the engagement of self ligands, yet avoiding autoreactivity...
  57. ncbi Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic
    Stanley Adoro
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 181:6975-83. 2008
    The mechanism by which CD4/CD8 lineage choice is coordinated with TCR specificity during positive selection remains an unresolved problem in immunology...
  58. ncbi Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail
    R H Seong
    Department of Medicine, Stanford University School of Medicine, California 94305 5111
    Nature 356:718-20. 1992
    Mature T cells express either CD4 or CD8 on their surface...
  59. ncbi Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene
    D R Littman
    Nature 325:453-5. 1987
    ..for a variety of functional studies, we have isolated, sequenced and expressed cDNA clones encoding the murine CD4 (L3T4) glycoprotein...
  60. ncbi Activation of virus-specific major histocompatibility complex class II-restricted CD8+ cytotoxic T cells in CD4-deficient mice
    M H Heemskerk
    Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    Eur J Immunol 25:1109-12. 1995
    ..hepatitis in mice and rats and induces a response of major histocompatibility complex (MHC) class II-restricted CD4+ cytotoxic T cells, protecting mice against acute infection...
  61. ncbi A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
    S Sawada
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0414
    Cell 77:917-29. 1994
    During development of T lymphocytes, differential regulation of expression of the CD4 and CD8 glycoproteins is coupled to the choice of one of two pathways of differentiation...
  62. ncbi Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
    C B Davis
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0414
    Cell 73:237-47. 1993
    Thymocytes that coexpress the CD4 and CD8 glycoproteins differentiate into mature CD4+ helper or CD8+ cytotoxic cells depending on whether their antigen receptors are specific for MHC class II or class I molecules, respectively...
  63. ncbi Helper T-cell development in the absence of CD4-p56lck association
    N Killeen
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0414
    Nature 364:729-32. 1993
    The CD4 and CD8 glycoproteins are expressed on helper and cytoxic T lymphocytes, respectively, and have important functions in the differentiation and activation of these cells...
  64. ncbi L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system
    J R Parnes
    Department of Medicine, Stanford University Medical Center, CA 94305
    Immunol Rev 100:109-27. 1987
    b>L3T4 is a mouse cell surface protein expressed on most thymocytes and on the subset of mature T cells that recognizes class II MHC molecules...
  65. ncbi Essential role for ZAP-70 in both positive and negative selection of thymocytes
    I Negishi
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 376:435-8. 1995
    ..Here we show that mice lacking ZAP-70 had neither CD4 nor CD8 single-positive T cells, but human ZAP-70 reconstituted both CD4 and CD8 single-positive populations...
  66. ncbi Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis
    Y Tada
    Amgen Institute, Ontario Cancer Institute, Ontario, Canada
    J Immunol 156:4520-6. 1996
    ..We studied CIA in CD4- or CD8-deficient DBA/1 mice to further define the roles of CD4+ and CD8+ T cells in the disease...
  67. ncbi Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
    Z Yao
    Immunex Corporation, Seattle, Washington 98101, USA
    Immunity 3:811-21. 1995
    ..These results define CTLA8 and HVS13 as novel cytokines that bind to a novel cytokine receptor. We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively...
  68. pmc Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice
    R A McIndoe
    Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:2210-4. 1999
    ..This locus (Cia4) was located on chromosome 2 and was linked to the same region as Cia2. Determining the identity of these loci may provide insights into the etiology of human rheumatoid arthritis...
  69. ncbi The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease
    P Liu
    Heart and Stroke Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Nat Med 6:429-34. 2000
    ..These data identify a previously unknown function of Src family kinases and indicate that p56lck is the essential host factor that controls the replication and pathogenicity of CVB3...
  70. ncbi Induction of acute pleural inflammation by Staphylococcus aureus. I. CD4+ T cells play a critical role in experimental empyema
    K A Mohammed
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Veterans Affairs Medical Center, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Infect Dis 181:1693-9. 2000
    ..001) lower in CD4+ knockout (CD4 KO) mice pleural fluid than in CD4+ wild-type (CD4 WT) mice...
  71. ncbi CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants
    M P Fischbein
    Department of Microbiology, Immunology, and Molecular Genetics, Division of Cardiothoracic Surgery, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 165:7316-22. 2000
    ..suggested that the development of chronic rejection in solid organ transplants is dependent on help mediated by CD4(+) lymphocytes...
  72. ncbi Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling
    M T Borchers
    Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    Am J Physiol Lung Cell Mol Physiol 281:L653-9. 2001
    ..We investigated the contribution of B and T cells, as well as CD4 expression, to the development of AHR in IL-5 transgenic mice. NJ...
  73. ncbi Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic mice
    S P Chapoval
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 108:764-71. 2001
    ..Airway inflammation is central to the pathogenesis of allergic asthma, and molecules that mediate this process obviously represent targets for therapy...
  74. pmc Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure
    M J Burne
    Division of Nephrology, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
    J Clin Invest 108:1283-90. 2001
    ..analyzed the contribution of the individual T cell subsets to postischemic injury and found that mice deficient in CD4(+) T cells, but not mice deficient in CD8(+) T cells, were significantly protected from ARF...
  75. ncbi An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis
    Andrea E Edling
    Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107, USA
    J Autoimmun 18:169-79. 2002
    b>CD4(+) T cells have an important role in mediating the pathogenesis of many human and experimental autoimmune diseases including experimental allergic encephalomyelitis (EAE), a demyelinating animal model for multiple sclerosis (MS)...
  76. pmc An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4
    Henry Kao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 201:149-58. 2005
    The CD4 coreceptor works together with the T cell receptor (TCR) to deliver signals to the developing thymocyte, yet its specific contribution to positive selection and CD4 lineage commitment remains unclear. To resolve this, we used N3...
  77. ncbi Dynamics of CD4+CD25+ T cells in spleens and mesenteric lymph nodes of mice infected with Schistosoma japonicum
    Xiao Ping Cai
    Department of Pathogenic Biology, Jiangsu Province Key Laboratory of Modern Pathogenic Biology, Nanjing Medical University, Nanjing 210029, China
    Acta Biochim Biophys Sin (Shanghai) 38:299-304. 2006
    b>CD4+CD25+ T cells play a major role in modulating immune response, but few reports have been published about schistosomiasis...
  78. ncbi Evidence for a domain-swapped CD4 dimer as the coreceptor for binding to class II MHC
    Akiko Maekawa
    Centre for Vascular Research, University of New South Wales, Sydney, Australia
    J Immunol 176:6873-8. 2006
    b>CD4 is a coreceptor for binding of T cells to APC and the primary receptor for HIV. The disulfide bond in the second extracellular domain (D2) of CD4 is reduced on the cell surface, which leads to formation of disulfide-linked homodimers...
  79. ncbi Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes
    Chi Wang Ip
    Department of Neurology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    J Neurosci 26:8206-16. 2006
    ..To investigate the role of CD8+ versus CD4+ T-lymphocytes, we reconstituted the myelin-RAG-1 double mutants with bone marrow from either CD8-negative (CD4+) ..
  80. pmc Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine
    Steven C Derrick
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Immunology 120:192-206. 2007
    ..yet induces significant protection against tuberculosis in wild-type mice and even in mice that completely lack CD4(+) T cells as a result of targeted disruption of their CD4 genes (CD4(-/-) mice)...
  81. pmc Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model
    Khie Khiong
    Department of Developmental Immunology, Graduate School of Medicine and Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Clin Invest 117:1270-81. 2007
    ..Depletion of CD4+ T cells in the mice caused a reduction in their IgE levels...
  82. ncbi Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression
    Taku Naito
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Immunity 27:723-34. 2007
    ..and its associate the chromatin remodeler Mi-2beta during T cell development, as exemplified by the regulation of Cd4 expression...
  83. doi Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells
    C Jackaman
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Eur Respir J 34:162-75. 2009
    ..The mesothelioma microenvironment contains stromal elements including dendritic cells, effector CD8(+) and CD4(+) T-cells, and CD4(+) T-regulatory (Tregs) cells, all of which are activated in situ, implying chronic ..
  84. doi Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help
    Daniel K Choo
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 185:3436-44. 2010
    ..It is well established that CD4 T cell help is critical for maintenance of CD8 T cells during chronic infections, but recent studies have suggested ..
  85. pmc Partial primary structure of the T4 antigens of mouse and sheep: assignment of intrachain disulfide bonds
    B J Classon
    Proc Natl Acad Sci U S A 83:4499-503. 1986
    ..The structural relationship of the T4 antigen to other members of the immunoglobulin supergene family is discussed...
  86. ncbi A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice
    V A Wallace
    Amgen Institute, Department of Immunology, University of Toronto, Ontario, Canada
    Eur J Immunol 24:1463-6. 1994
    ..To determine the role of T cell subsets in the pathogenesis of fibrotic disease, Tsk/+ mice were bred with CD4- and CD8-deficient (CD4-/- and CD8-/-) mice...
  87. ncbi CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi
    T V Rajan
    Department of Pathology, University of Connecticut Health Center, Farmington 06030
    Exp Parasitol 78:352-60. 1994
    ..In the present study, we have examined the role of CD4+ T-lymphocytes in resistance to filarial infection using two experimental systems...
  88. ncbi Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice
    W L Hazenbos
    Department of Immunology, University Hospital Utrecht, The Netherlands
    Immunity 5:181-8. 1996
    ..These results indicate a prominent role for Fc gamma RIII in inflammatory and anaphylactic responses, making this receptor a potential target in immunotherapy...
  89. ncbi IL-10 inhibits lipopolysaccharide-induced murine B cell proliferation and cross-linking of surface antigen receptors or ligation of CD40 restores the response
    J F Marcelletti
    LIDAK Pharmaceuticals, La Jolla, CA 92037, USA
    J Immunol 157:3323-33. 1996
    ..These observations suggest that IL-10 has a role in the suppression of inappropriate B cell proliferation, i.e., proliferation by B cells that have not effectively interacted with relevant Ag or CD40 ligand...
  90. ncbi Novel mutant mice secreting soluble CD4 without expression of membrane-bound CD4
    H Nagase
    Department of Allergology, Institute of Medical Science, University of Tokyo, Japan
    Eur J Immunol 28:403-12. 1998
    Mutant mice derived from C57BR/cdJ mice were found to have a novel genetic defect in CD4 expression...
  91. ncbi Cloning of a novel C-type lectin expressed by murine macrophages
    S G Balch
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 273:18656-64. 1998
    ..The mcl gene locus has been mapped between the genes for the interleukin-17 receptor and CD4 on mouse chromosome 6, the same chromosome as the mouse natural killer cell gene complex.
  92. pmc Altered thymic positive selection and intracellular signals in Cbl-deficient mice
    M Naramura
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 95:15547-52. 1998
    ..Second, Cbl-deficient thymocytes expressed CD3 and CD4 molecules at higher levels, which consequently may increase the avidity of TCR/major histocompatibility complex/..
  93. ncbi Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1
    G B Mulder
    University Laboratory Animal Resources, University of California at Irvine 92697 1310, USA
    Teratology 58:263-75. 1998
    ..Further, the observed defects in thymus development may be mediated by RA-induced alterations in the expression of Hoxa3...
  94. ncbi Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: identification of regulatory cells
    F D Shi
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    J Immunol 162:5757-63. 1999
    ..Splenocytes from AChR-pretreated wt and CD8-/- mice, but not from CD4-/- mice, suppressed AChR-specific lymphocyte proliferation...
  95. ncbi CD8+ CTLs are essential for protective immunity against Encephalitozoon cuniculi infection
    I A Khan
    Departments ofMedicine and Microbiology and Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 162:6086-91. 1999
    ..Whereas CD4-/- animals resolved the infection, mice lacking CD8+ T cells or perforin gene succumbed to parasite challenge...
  96. ncbi A novel mouse model of HIV-1 disease
    P Jolicoeur
    Clinical Research Institute of Montreal, McGill University, Quebec, Canada
    Leukemia 13:S78-80. 1999
  97. ncbi Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions
    R T Graser
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 164:3913-8. 2000
    ..such CD8 T cells have previously been thought to require helper functions provided by MHC class II-restricted CD4 T cells to exert their full diabetogenic effects...
  98. pmc Induction of CD4(+) T-cell-independent immunoglobulin responses by inactivated influenza virus
    Z Sha
    Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322, USA
    J Virol 74:4999-5005. 2000
    Through cognate interaction between antigen-specific B-cell and CD4(+) alphabeta T cells, the CD4(+) alphabeta T cells secrete cytokines that initiate immunoglobulin (Ig) class switching from IgM to IgG...
  99. ncbi Use of human CD4 transgenic mice for studying immunogenicity of HIV-1 envelope protein gp120
    J Seagal
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Transgenic Res 10:113-20. 2001
    ..A specific feature of this protein is its interaction with the receptor protein, human CD4, an important component of the immune system...
  100. ncbi B cell immunodeficiency fails to develop in CD4-deficient mice infected with BM5: murine AIDS as a multistep disease
    D P Harris
    The Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 166:6041-9. 2001
    ..caused by the BM5 retrovirus preparation, involves the activation, division, and subsequent anergy of the entire CD4(+) T cell population as well as extensive B cell hyperproliferation and hypergammaglobulinemia, resulting in ..
  101. ncbi Distinct regulatory elements are required for faithful expression of human CD4 in T cells, macrophages, and dendritic cells of transgenic mice
    Z Hanna
    Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Blood 98:2275-8. 2001
    To identify the regulatory elements controlling expression of the human CD4 (hCD4) gene in different cell types of the immune system, deletion and chimeric (human/murine) reporter genes were constructed and tested in transgenic (Tg) mice...

Research Grants14

  1. Modulation of T cell Responses by Ebola Glycoprotein
    Hao Shen; Fiscal Year: 2003
    ....
  2. Protective role of cross-reactive anti-enteric antibody
    Lynn Bry; Fiscal Year: 2005
    ....
  3. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2007
    ..chaffeensis and other closely related organisms. ..
  4. Regulation of Lineage Specificity of CD4 Silencing
    Yong Rui Zou; Fiscal Year: 2008
    The CD4 coreceptor molecule is essential for the generation and function of T helper-lineage cells. Its expression is strictly regulated during T cell development...
  5. Targeting TLR/CLR to enhance immunoregulation and prevent or treat diabetes.
    Pascale Alard; Fiscal Year: 2007
    ..Studies have shown that CD4+CD25+ regulatory T cell function is reduced in NOD mice and diabetic patients...
  6. T cell immunity and cytokine receptor redundancy
    THOMAS MALEK; Fiscal Year: 2005
    ..Our goal here is to relate molecular targets of IL-2R signaling with specific biological responses. ..
  7. Role of T cells in self-limited mucosal infections
    Lynn Bry; Fiscal Year: 2006
    ..B cells and CD4+ T cells are required to survive infection with Citrobacter rodentium, the mouse homolog for the enteropathogenic E...
  8. New attenuated anthrax vaccine
    Hao Shen; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  9. Cellular Immune Surveillance of Intracellular bacteria
    Hao Shen; Fiscal Year: 2008
    ..abstract_text> ..
  10. IMMUNE PROMOTION OF REMYELINATION
    Moses Rodriguez; Fiscal Year: 2008
    ..Our findings are expected to provide new insights into the enhancement of remyelination in diseases such as multiple sclerosis. [unreadable] [unreadable]..
  11. Development of Cellular Assays of Dengue Virus Infection
    Priscilla Yang; Fiscal Year: 2008
    ..These inhibitors can be used to study how dengue virus interacts with its host, and they may also be useful in developing therapies for the treatment of dengue virus infections. [unreadable] [unreadable] [unreadable]..
  12. The IL-2 receptor in T regulatory cell development
    Thomas R Malek; Fiscal Year: 2010
    ..abstract_text> ..
  13. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2010
    ..We will also examine the interaction of MHC molecules on CNS cells with CD8+ T cells, CD4+T cells, NK cells, macrophages, and perforin in the spinal cords of animals with chronic demyelination induced by ..
  14. Crimson - i2b2 integration for high-throughput, scalable sample collection
    Lynn Bry; Fiscal Year: 2010
    ....