Cd38

Summary

Gene Symbol: Cd38
Description: CD38 antigen
Alias: ADPRC 1, Cd38-rs1, I-19, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, NIM-R5 antigen, cADPr hydrolase 1, cyclic ADP-ribose hydrolase 1
Species: mouse

Top Publications

  1. ncbi Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity
    H Nishina
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    Biochem Biophys Res Commun 203:1318-23. 1994
  2. ncbi Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses
    D A Cockayne
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    Blood 92:1324-33. 1998
  3. ncbi CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretion
    I Kato
    Department of Biochemistry, Tohoku University School of Medicine, Sendai 980 8575, Miyagi, Japan
    J Biol Chem 274:1869-72. 1999
  4. ncbi Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo
    S Partida-Sanchez
    Trudeau Institute, Saranac Lake, New York, USA
    Nat Med 7:1209-16. 2001
  5. ncbi Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption
    Li Sun
    Mount Sinai Bone Program and Department of Medicine and Geriatrics, Mount Sinai School of Medicine, and Division of Endocrinology and Geriatric Research Education and Clinical Center GRECC, Veterans Affairs Medical Center, New York, New York 10029, USA
    FASEB J 17:369-75. 2003
  6. ncbi Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by gender
    Jun Takahashi
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Biochem Biophys Res Commun 312:434-40. 2003
  7. ncbi Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity
    Santiago Partida-Sanchez
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Immunity 20:279-91. 2004
  8. ncbi CD38 is expressed selectively during the activation of a subset of mature T cells with reduced proliferation but improved potential to produce cytokines
    Claudia Sandoval-Montes
    Departamento de Biomedicina Molecular, Centro de Investigacion y Estudios Avanzados, IPN, Mexico
    J Leukoc Biol 77:513-21. 2005
  9. ncbi CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins
    Christian Krebs
    Institute of Immunology, University Hospital, Hamburg, Germany
    J Immunol 174:3298-305. 2005
  10. ncbi Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion
    Jing Chen
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 176:4590-9. 2006

Research Grants

  1. OXYTOCIN AND SOCIAL ATTACHMENT
    Larry Young; Fiscal Year: 2006

Scientific Experts

  • H Higashida
  • Nicholas G Moss
  • Tiffany L Thai
  • Marta S Viegas
  • Alonso G P Guedes
  • Miki Hara-Yokoyama
  • James D Johnson
  • Chi Un Choe
  • Genevieve S Young
  • Keichiro Mihara
  • Larry Young
  • Eduardo Chini
  • Xinhua Yu
  • D A Cockayne
  • F E Lund
  • Uh Hyun Kim
  • Jameel Iqbal
  • Santiago Partida-Sanchez
  • Leopoldo Santos-Argumedo
  • So Young Rah
  • Miguel E Moreno-Garcia
  • Friedrich Koch-Nolte
  • Friedrich Haag
  • Yi Guang Chen
  • Ming Xu
  • Pin Lan Li
  • Thomas A White
  • Ayelet Levy
  • Pinar Aksoy
  • Mone Zaidi
  • Li Sun
  • Lior Mayo
  • Sahil Adriouch
  • Guixiu Shi
  • Edward H Leiter
  • Marie Jo Moutin
  • Min Xia
  • Mazhar Mushtaq
  • Fan Zhang
  • Carlos Escande
  • Hiroshi Okamoto
  • Shin Takasawa
  • Ichiro Kato
  • Michael Thompson
  • Reuven Stein
  • Kwang Hyun Park
  • Claire Ceni
  • Sandra Hubert
  • David V Serreze
  • Hong Xiang Liu
  • Michel Seman
  • Somi Kim
  • Andreas H Guse
  • Hector Romero-Ramirez
  • Jing Chen
  • Claudia Sandoval-Montes
  • Abrahim I Orabi
  • Adriana Sumoza-Toledo
  • Julia Etich
  • Timo Lischke
  • Joseph K Ritter
  • Yang Zhang
  • Xiao Xue Li
  • Krishna M Boini
  • Maria Thereza Barbosa
  • John Kang
  • Felipe Vences-Catalán
  • Jorge Postigo
  • Veronica Nin
  • Hans Willi Mittrücker
  • Hélène Muller-Steffner
  • Francis Schuber
  • Norman Oppenheimer
  • Leonie Durnin
  • L A Estrada-Figueroa
  • Lu Gan
  • Frederike Schmid
  • Saurabh Sahar
  • Shujun Liu
  • Daniel T Patton
  • Tae Sik Nam
  • François Cosker
  • T Vaisitti
  • Fabienne Gally
  • Asif Iqbal Shawl
  • Yumiko Tsukamoto
  • Felix Scheuplein
  • Peter C Reifsnyder
  • Juan C Rodríguez-Alba
  • Rukhsana Gul

Detail Information

Publications103 found, 100 shown here

  1. ncbi Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity
    H Nishina
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    Biochem Biophys Res Commun 203:1318-23. 1994
    ..by retinoic acid in human leukemic HL-60 cells is attributed to the molecule of leukocyte cell surface antigen CD38 (Kontani, K., et al. (1993) J. Biol. Chem. 268, 16895-16898)...
  2. ncbi Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses
    D A Cockayne
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    Blood 92:1324-33. 1998
    b>CD38 is a membrane-associated ecto-nicotinamide adenine dinucleotide (NAD+) glycohydrolase that is expressed on multiple hematopoietic cells...
  3. ncbi CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretion
    I Kato
    Department of Biochemistry, Tohoku University School of Medicine, Sendai 980 8575, Miyagi, Japan
    J Biol Chem 274:1869-72. 1999
    ..has been postulated to serve as a second messenger for intracellular Ca2+ mobilization for insulin secretion, and CD38 is thought to be involved in the cADPR accumulation (Takasawa, S., Tohgo, A., Noguchi, N., Koguma, T., Nata, K...
  4. ncbi Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo
    S Partida-Sanchez
    Trudeau Institute, Saranac Lake, New York, USA
    Nat Med 7:1209-16. 2001
    ..b>CD38, the best-characterized mammalian ADP-ribosyl cyclase, is postulated to be an important source of cyclic ADP-ribose ..
  5. ncbi Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption
    Li Sun
    Mount Sinai Bone Program and Department of Medicine and Geriatrics, Mount Sinai School of Medicine, and Division of Endocrinology and Geriatric Research Education and Clinical Center GRECC, Veterans Affairs Medical Center, New York, New York 10029, USA
    FASEB J 17:369-75. 2003
    We have evaluated the role of the ADP-ribosyl cyclase, CD38, in bone remodeling, a process by which the skeleton is being renewed constantly through the coordinated activity of osteoclasts and osteoblasts...
  6. ncbi Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by gender
    Jun Takahashi
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Biochem Biophys Res Commun 312:434-40. 2003
    To elucidate whether myocardial CD38/cyclic ADP-ribose (cADPR) signaling plays a physiological role, we investigated the heart of CD38 knockout mice (CD38KO)...
  7. ncbi Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity
    Santiago Partida-Sanchez
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Immunity 20:279-91. 2004
    Mice lacking CD38, an ectoenzyme that generates the calcium-mobilizing metabolite cADPR, make reduced T cell-dependent antibody responses...
  8. ncbi CD38 is expressed selectively during the activation of a subset of mature T cells with reduced proliferation but improved potential to produce cytokines
    Claudia Sandoval-Montes
    Departamento de Biomedicina Molecular, Centro de Investigacion y Estudios Avanzados, IPN, Mexico
    J Leukoc Biol 77:513-21. 2005
    b>CD38 is an approximately 45-kDa type II transmembrane glycoprotein expressed by hematopoietic and nonhematopoietic cells...
  9. ncbi CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins
    Christian Krebs
    Institute of Immunology, University Hospital, Hamburg, Germany
    J Immunol 174:3298-305. 2005
    ..This in turn activates P2X7 and induces exposure of phosphatidylserine and shedding of CD62L. CD38, a potent ecto-NAD-glycohydrolase, is strongly expressed by most B cells but only weakly by T cells...
  10. ncbi Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion
    Jing Chen
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 176:4590-9. 2006
    Ubiquitously expressed CD38 and T cell-expressed ADP-ribosyltransferase 2 (ART2) are ectoenzymes competing for NAD substrate...
  11. ncbi Regulation of intracellular levels of NAD: a novel role for CD38
    Pinar Aksoy
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN, USA
    Biochem Biophys Res Commun 345:1386-92. 2006
    ..However, to date, the mechanisms that regulate intracellular levels of NAD have not been completely elucidated. CD38 is a multifunctional enzyme ubiquitously distributed in mammalian tissues...
  12. ncbi Decreased cADPR and increased NAD+ in the Cd38-/- mouse
    Genevieve S Young
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ont, Canada N1G 3W1
    Biochem Biophys Res Commun 346:188-92. 2006
    b>CD38 is a type II glycoprotein that catalyzes the formation of cyclic ADP-ribose (cADPR), an intracellular calcium signalling molecule, from nicotinamide adenine dinucleotide (NAD(+))...
  13. ncbi Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38
    Pinar Aksoy
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN, USA
    Biochem Biophys Res Commun 349:353-9. 2006
    ..How the endogenous activity of SIRT 1 is modulated is not known. The enzyme CD38 is a multifunctional enzyme capable of synthesis of the second messenger, cADPR, NAADP, and ADPR...
  14. ncbi CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses
    Santiago Partida-Sanchez
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Adv Exp Med Biol 590:171-83. 2007
  15. ncbi CD38 is critical for social behaviour by regulating oxytocin secretion
    Duo Jin
    Kanazawa University 21st Century COE Program on Innovative Brain Science on Development, Learning and Memory, Kanazawa 920 8640, Japan
    Nature 446:41-5. 2007
    b>CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the formation of Ca2+ signalling molecules, but its role in the neuroendocrine system is unknown...
  16. pmc Signaling properties of CD38 in the mouse immune system: enzyme-dependent and -independent roles in immunity
    Frances E Lund
    Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Mol Med 12:328-33. 2006
    The 5th international CD38 meeting, held in Torino, Italy, spanned a range of topics from the role of CD38 as a signaling receptor in lymphocytic tumors to the importance of CD38-derived metabolites in NAD(+) metabolism, calcium signaling,..
  17. ncbi NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo
    Sahil Adriouch
    University Denis Diderot Paris 7, EA 1556 Paris, France
    J Immunol 179:186-94. 2007
    ..This leads to T cell depletion in the draining lymph nodes from wild-type and, more severely, from mice lacking the CD38 NAD(+) glycohydrolase, whereas no effect is observed in ART2-deficient animals...
  18. ncbi ADP-ribosyl cyclase and ryanodine receptor activity contribute to basal renal vasomotor tone and agonist-induced renal vasoconstriction in vivo
    Tiffany L Thai
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Renal Physiol 293:F1107-14. 2007
    ..001). RBF studies in rats were extended to mice lacking the predominant form of ADPR cyclase (CD38)...
  19. ncbi Role of CD38 in TNF-alpha-induced airway hyperresponsiveness
    Alonso G P Guedes
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Am J Physiol Lung Cell Mol Physiol 294:L290-9. 2008
    b>CD38 is involved in normal airway function, IL-13-induced airway hyperresponsiveness (AHR), and is also regulated by tumor necrosis factor (TNF)-alpha in airway smooth muscle (ASM) cells...
  20. doi CD38 induces differentiation of immature transitional 2 B lymphocytes in the spleen
    Juan C Rodríguez-Alba
    Departamento de Biomedicina Molecular, Centro de Investigacion y de Estudios Avanzados, and Universidad Nacional Autónoma de México, Mexico City, Mexico
    Blood 111:3644-52. 2008
    b>CD38 is a surface receptor able to induce activation, proliferation, and survival of human and mouse lymphocytes; this molecule is expressed on the surface of both mature and immature B cells...
  21. pmc Dual role of CD38 in microglial activation and activation-induced cell death
    Lior Mayo
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    J Immunol 181:92-103. 2008
    ..Using mouse primary microglial cultures, we show that the ectoenzyme CD38, via its calcium-mobilizing metabolite cyclic-ADP-ribose (cADPR), helps promote microglial activation and AICD ..
  22. pmc Mice lacking the ADP ribosyl cyclase CD38 exhibit attenuated renal vasoconstriction to angiotensin II, endothelin-1, and norepinephrine
    Tiffany L Thai
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Renal Physiol 297:F169-76. 2009
    ..At least two ADPR cyclase family members have been identified in mammals: CD38 and CD157...
  23. pmc Lysosome-dependent Ca(2+) release response to Fas activation in coronary arterial myocytes through NAADP: evidence from CD38 gene knockouts
    Fan Zhang
    Dept of Pharmacology and Toxicology, Virginia Commonwealth Univ, Richmond, 23298, USA
    Am J Physiol Cell Physiol 298:C1209-16. 2010
    ..The hypothesis being tested is that CD38 signaling pathway mediates FasL-induced intracellular Ca(2+) release through nicotinic acid adenine dinucleotide ..
  24. pmc The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells
    François Cosker
    CNRS, Institut de Neurobiologie Alfred Fessard, FRC2118, Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR9040, F 91198 Gif sur Yvette, France
    J Biol Chem 285:38251-9. 2010
    ..The ecto-enzyme CD38, involved in many functions as diverse as cell proliferation and social behavior, represents an important ..
  25. pmc Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway
    Sandra Hubert
    Institut National de la Sante et de la Recherche Medicale, U905, 76183 Rouen, France
    J Exp Med 207:2561-8. 2010
    ..Moreover, lower T reg cell numbers are found in mice deficient for the NAD-hydrolase CD38 than in wild-type, P2X7-deficient, or ART2-deficient mice, indicating a role for extracellular NAD(+) in T reg cell ..
  26. pmc CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia
    Chi Un Choe
    Department of Neurology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e19046. 2011
    ..e., macrophages and microglia. The bifunctional receptor and ectoenzyme CD38 synthesizes calcium-mobilizing second messengers (e.g...
  27. pmc Implication of CD38 gene in podocyte epithelial-to-mesenchymal transition and glomerular sclerosis
    Krishna M Boini
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Cell Mol Med 16:1674-85. 2012
    b>CD38 is a multifunctional protein involving in a number of signalling pathways...
  28. pmc NAD(P)H oxidase-dependent intracellular and extracellular O2•- production in coronary arterial myocytes from CD38 knockout mice
    Ming Xu
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Free Radic Biol Med 52:357-65. 2012
    ..However, it remains unknown how the activity of NAD(P)H oxidase is regulated in arterial myocytes. Recently, CD38-associated ADP-ribosylcyclase has been reported to use an NAD(P)H oxidase product, NAD(+) or NADP(+), to produce ..
  29. doi CD38 and its role in oxytocin secretion and social behavior
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Horm Behav 61:351-8. 2012
    Here, we review the functional roles of cyclic ADP-ribose and CD38, a transmembrane protein with ADP-ribosyl cyclase activity, in mouse social behavior via the regulation of oxytocin (OXT) release, an essential component of social ..
  30. doi Social memory, amnesia, and autism: brain oxytocin secretion is regulated by NAD+ metabolites and single nucleotide polymorphisms of CD38
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Neurochem Int 61:828-38. 2012
    Previously, we demonstrated that CD38, a transmembrane protein with ADP-ribosyl cyclase activity, plays a critical role in mouse social behavior by regulating the release of oxytocin (OXT), which is essential for mutual recognition...
  31. ncbi CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice
    Yi Guang Chen
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 177:2939-47. 2006
    ..Conversely, T1D is accelerated in NOD mice lacking CD38 molecules that play a role in dendritic cell migration to inflamed tissues...
  32. ncbi The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity
    Maria Thereza P Barbosa
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    FASEB J 21:3629-39. 2007
    ..Here, we demonstrate a novel role for protein CD38 as a regulator of body weight during a high-fat diet...
  33. ncbi Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca(2+) signaling using CD38 knockout mice
    Y Fukushi
    Department of Physiology I, Tohoku University Graduate School of Medicine, Seiryo cho 2 1, Aobaku, Sendai 980 8575, Japan
    J Biol Chem 276:649-55. 2001
    ..increased the cellular content of cADPR in the pancreatic acinar cells from normal mice but not in those from CD38 knockout mice...
  34. doi Absence of CD38 delays arrival of neutrophils to the liver and innate immune response development during hepatic amoebiasis by Entamoeba histolytica
    L A Estrada-Figueroa
    Departamento de Infectómica y Patogénesis Molecular, CINVESTAV IPN, Mexico, DF, Mexico
    Parasite Immunol 33:661-8. 2011
    To define the role of CD38 in the migration of neutrophils to the liver and consequently in the induction of an innate immune response during murine hepatic amoebiasis by Entamoeba histolytica, we examined amoebic liver abscess ..
  35. pmc Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome
    Carlos Escande
    Department of Anesthesiology and Kogod Aging Center, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 62:1084-93. 2013
    ..Previously, we reported that CD38 is the primary NAD(+)ase in mammals...
  36. pmc Cluster of differentiation 38 (CD38) mediates bile acid-induced acinar cell injury and pancreatitis through cyclic ADP-ribose and intracellular calcium release
    Abrahim I Orabi
    From the Departments of Pediatrics and
    J Biol Chem 288:27128-37. 2013
    ..the nucleotide second messenger cyclic ADP-ribose (cADPR), which is generated by an ectoenzyme ADP-ribosyl cyclase, CD38. In this study, we examined the role of CD38 and cADPR in acinar cell Ca(2+) signals and acinar injury due to bile ..
  37. pmc Contribution of NADPH oxidase to membrane CD38 internalization and activation in coronary arterial myocytes
    Ming Xu
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    PLoS ONE 8:e71212. 2013
    The CD38-ADP-ribosylcyclase-mediated Ca(2+) signaling pathway importantly contributes to the vasomotor response in different arteries...
  38. pmc CD38 controls the innate immune response against Listeria monocytogenes
    Timo Lischke
    Institute of Immunology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Infect Immun 81:4091-9. 2013
    b>CD38, adenosine-5'-diphosphate-ribosyl cyclase 1, is a multifunctional enzyme, expressed on a wide variety of cell types...
  39. pmc CD38 expression in early B-cell precursors contributes to extracellular signal-regulated kinase-mediated apoptosis
    Hector Romero-Ramirez
    Department of Molecular Biomedicine, Centre for Research and Advanced Studies CINVESTAV IPN, Mexico City, Mexico Department of Immunology, National School of Biological Sciences, IPN, Mexico City, Mexico
    Immunology 144:271-81. 2015
    b>CD38 is a 45,000 molecular weight transmembrane protein that is expressed in immature and mature lymphocytes. However, the expression and function of CD38 during B-cell differentiation in mice is poorly understood...
  40. pmc Airway responsiveness in CD38-deficient mice in allergic airway disease: studies with bone marrow chimeras
    Alonso G P Guedes
    Department of Surgical and Radiological Sciences, University of California, Davis, California
    Am J Physiol Lung Cell Mol Physiol 308:L485-93. 2015
    b>CD38 is a cell-surface protein involved in calcium signaling and contractility of airway smooth muscle...
  41. pmc CD38-mediated Ca(2+) signaling contributes to glucagon-induced hepatic gluconeogenesis
    So Young Rah
    Department of Biochemistry and National Creative Research Laboratory for Ca2 signaling Network
    Sci Rep 5:10741. 2015
    b>CD38 is a multifunctional enzyme for the synthesis of Ca(2+) second messengers. Glucagon promotes hepatic glucose production through Ca(2+) signaling in the fasting condition...
  42. pmc Impaired learning and memory in CD38 null mutant mice
    Somi Kim
    Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Gwanak Gu, Seoul, 08826, South Korea
    Mol Brain 9:16. 2016
    b>CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca(2+) from intracellular stores...
  43. pmc Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation
    Saurabh Sahar
    Department of Pharmacology, University of California, Irvine, 92697, USA
    Aging (Albany NY) 3:794-802. 2011
    ..To address this question we analyzed mice mutated for the NAD(+) hydrolase CD38. We found that rhythmicity of NAD(+) was altered in the CD38-deficient mice...
  44. doi CD38: a NAADP degrading enzyme
    Frederike Schmid
    Department of Biochemistry and Signal Transduction, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    FEBS Lett 585:3544-8. 2011
    The role of the multifunctional enzyme CD38 in formation of the Ca(2+)-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated...
  45. pmc The role of CD38 in Fcγ receptor (FcγR)-mediated phagocytosis in murine macrophages
    John Kang
    Department of Biochemistry, Chonbuk National University Medical School, Jeonju, 561 180, Korea
    J Biol Chem 287:14502-14. 2012
    ..However, it is unclear whether and how CD38 is involved in FcγR-mediated phagocytosis...
  46. pmc Mice deficient in CD38 develop an attenuated form of collagen type II-induced arthritis
    Jorge Postigo
    Departmento de Biologia Molecular, Instituto de Formación e Investigación Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain
    PLoS ONE 7:e33534. 2012
    b>CD38, a type II transmembrane glycoprotein expressed in many cells of the immune system, is involved in cell signaling, migration and differentiation...
  47. pmc The CD19/CD81 complex physically interacts with CD38 but is not required to induce proliferation in mouse B lymphocytes
    Felipe Vences-Catalán
    Departamento de Biomedicina Molecular, CINVESTAV IPN, Mexico, D F, Mexico
    Immunology 137:48-55. 2012
    In B lymphocytes, the cell surface receptor CD38 is involved in apoptosis of immature B cells, proliferation and differentiation of mature B cells...
  48. pmc CD38 deficiency in the tumor microenvironment attenuates glioma progression and modulates features of tumor-associated microglia/macrophages
    Ayelet Levy
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    Neuro Oncol 14:1037-49. 2012
    ..There is increasing evidence that the tumor-associated MM support glioma expansion. CD38 is a multifunctional ectoenzyme that uses nicotinamide adenine dinucleotide as a substrate to generate second ..
  49. pmc PECAM1(+)/Sca1(+)/CD38(+) vascular cells transform into myofibroblast-like cells in skin wound repair
    Julia Etich
    Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, North Rhine Westphalia, Germany
    PLoS ONE 8:e53262. 2013
    ..These cells express endothelial and perivascular markers and present the receptor CD38 on their surface...
  50. ncbi Murine CD38: an immunoregulatory ectoenzyme
    F Lund
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunol Today 16:469-73. 1995
    b>CD38 is an ectoenzyme that utilizes NAD+ and is expressed by many cells of hematopoietic origin. Antibodies to CD38 potentiate many biological activities on lymphocytes, including induction of murine B-cell proliferation...
  51. pmc CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation
    K F Byth
    Department of Pathology, Cambridge University, United Kingdom
    J Exp Med 183:1707-18. 1996
    ..The proliferation of B cells in response to CD38 cross-linking is significantly reduced but not abolished by the CD45-null mutation...
  52. ncbi Human CD38, a leukocyte receptor and ectoenzyme, is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide+-converting enzymes: extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aplysia
    E Ferrero
    Department of Genetics, Biology, and Medical Chemistry, University of Torino, Italy
    J Immunol 159:3858-65. 1997
    The human leukocyte Ag CD38 is a 45-kDa type II membrane glycoprotein that functions both as a transmembrane signaling receptor and as an ectoenzyme...
  53. pmc Molecular cloning and functional expression of bovine spleen ecto-NAD+ glycohydrolase: structural identity with human CD38
    A Augustin
    Laboratoire de Chimie Bioorganique, UMR 7514 CNRS ULP, Faculte de Pharmacie, 74 route du Rhin, 67400 Strasbourg Illkirch, France
    Biochem J 345:43-52. 2000
    ..2.2.6), displays catalytic features similar to those of CD38, i.e...
  54. ncbi Signals that initiate somatic hypermutation of B cells in vitro
    S Bergthorsdottir
    Department of Immunology, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    J Immunol 166:2228-34. 2001
    ..three signals are required to allow detection of somatic mutation in vitro; these are anti-Ig, anti-CD40, and anti-CD38. If any one of these is omitted, mutation remains off...
  55. ncbi Protein kinase C isoenzyme: selective expression pattern of protein kinase C-θ during mouse development
    M Wilda
    Abteilung Humangenetik, Universitat Ulm, D 89069 Ulm, Germany
    Mech Dev 103:197-200. 2001
    ..Expression is also evident in skeletal muscle. A further highly specific expression was observed in the peripheral and central nervous system which is described in detail. Expression in the brain persists up to adult stages...
  56. pmc CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues
    Eduardo N Chini
    Department of Anesthesia, Mayo Clinic and Foundation, 200 First Street, Rochester, MN 55905, U S A
    Biochem J 362:125-30. 2002
    In the present study, we have determined the role of the enzyme CD38 upon the synthesis of the Ca(2+)-releasing nucleotide nicotinic acid-adenine dinucleotide phosphate (NAADP)...
  57. ncbi Does neutrophil CD38 have a role in Ca++ signaling triggered by beta2 integrin?
    Sharon Dewitt
    Nat Med 8:307; author reply 307-8. 2002
  58. ncbi Enhanced activation of CD83-positive T cells
    M Wolenski
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Scand J Immunol 58:306-11. 2003
    ..Thus, the expression of CD83 on T cells has direct functional consequences for tuning the activation threshold...
  59. pmc Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors
    Santina Bruzzone
    Department of Experimental Medicine, University of Genova, Italy
    J Cell Biol 163:837-45. 2003
    ..Either (1) 3T3 fibroblasts (CD38- cells), (2) 3T3 fibroblasts preloaded by incubation with extracellular cyclic ADP-ribose (cADPR), (3) 3T3 ..
  60. ncbi CD38 gene disruption inhibits the contraction induced by alpha-adrenoceptor stimulation in mouse aorta
    Minori Mitsui-Saito
    Department of Molecular Pharmacology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    J Vet Med Sci 65:1325-30. 2003
    b>CD38 is an ectoenzyme with ADP-ribosyl cyclase and hydrolase activities, which synthesizes cyclic ADP-ribose from NAD and hydrolyzes cyclic ADP-ribose to ADP-ribose...
  61. ncbi Altered airway responsiveness in CD38-deficient mice
    Deepak A Deshpande
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, Saint Paul, MN 55108, USA
    Am J Respir Cell Mol Biol 32:149-56. 2005
    ..In this study we determined the functional role of CD38/cADPR signaling in the regulation of airway tone using CD38 deficient (cd38(-/-)) mice...
  62. ncbi Localization of CD38 in murine B lymphocytes to plasma but not intracellular membranes
    Miguel E Moreno-Garcia
    Departamento de Biomedicina Molecular, Centro de Investigacion y Estudios Avanzados del I P N, Apartado Postal 14 740, CP 07360 México D F, Mexico
    Mol Immunol 42:703-11. 2005
    b>CD38 has been widely characterized both as an ecto-enzyme and as a receptor...
  63. pmc The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain
    Claire Ceni
    Laboratoire Canaux Ioniques et Signalisation, INSERM E9931, DRDC CEA UJF Grenoble, 17 Avenue des Martyrs, 38051 Grenoble Cedex 9, France
    Biochem J 395:417-26. 2006
    ..We also demonstrate, by comparing wild-type and Cd38-/- tissues, that brain cADPR content is independent of the presence of CD38 (the best characterized mammalian ADP-..
  64. pmc M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice
    Dominik Schenten
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Blood 107:4849-56. 2006
    ..Thus, M17 is dispensable for the GC reaction, and its potential function in the pathogenesis of DLBCL remains elusive...
  65. ncbi TNF regulates cellular NAD+ metabolism in primary macrophages
    Jameel Iqbal
    Department of Endocrinology and Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Biophys Res Commun 342:1312-8. 2006
    ..served to increase NAD(+) levels, such as IDO and PBEF, as well as enzymes that decrease NAD(+) levels, such as CD38 and CD157...
  66. ncbi CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge
    Alonso G P Guedes
    Department of Veterinary Clinicial Sciences, University of Minnesota, St Paul, MN 55108, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1286-93. 2006
    The transmembrane glycoprotein CD38 in airway smooth muscle is the source of cyclic-ADP ribose, an intracellular calcium-releasing molecule, and is subject to regulatory effects of cytokines such as interleukin (IL)-13, a cytokine ..
  67. ncbi Suppressed insulin signaling and increased apoptosis in CD38-null islets
    James D Johnson
    Division of Metabolism, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 55:2737-46. 2006
    b>CD38 is a multifunctional enzyme capable of generating metabolites that release Ca2+ from intracellular stores, including nicotinic acid adenine dinucleotide phosphate (NAADP)...
  68. ncbi CD38 is required for priming by TNF-alpha: a mechanism for extracellular coordination of cell fate
    Jameel Iqbal
    Mount Sinai Bone Program, Mount Sinai School of Medicine, Box 1055, 1 Gustave Levy Place, New York, NY 10029, USA
    Am J Physiol Renal Physiol 292:F1283-90. 2007
    ..it is shown that the cytokine TNF-alpha is capable of affecting the fate of macrophages by upregulating the NADase CD38. CD38 upregulation primes macrophages, such that signals induced by inflammatory stimuli are augmented, while those ..
  69. ncbi CD38 cross-linking enhances TLR-induced B cell proliferation but decreases IgM plasma cell differentiation
    Nataly Manjarrez-Orduno
    Molecular Biomedicine Department, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico City, Mexico
    Eur J Immunol 37:358-67. 2007
    ..The cross-linking of the surface molecule CD38 induces calcium mobilization, protein phosphorylation and NF-kappaB translocation into the nucleus, ultimately ..
  70. ncbi Regulating the social brain: a new role for CD38
    Larry J Young
    Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Neuron 54:353-6. 2007
    ..A recent paper by Jin et al. published in Nature demonstrates that the transmembrane receptor CD38 plays a critical role in regulating social behaviors by regulating the release of OT from hypothalamic neurons.
  71. ncbi Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction
    Santiago Partida-Sanchez
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 179:7827-39. 2007
    The ectoenzyme CD38 catalyzes the production of cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from its substrate, NAD(+)...
  72. pmc TNF-induced oscillations in combinatorial transcription factor binding
    Li Sun
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, PO BOX 1055, Endocrinology, New York, NY 10029, USA
    Biochem Biophys Res Commun 371:912-6. 2008
    ..We utilize the late onset gene CD38 as a model gene since it has previously been shown that TNF, but not the related cytokine RANK-L, induces its ..
  73. pmc ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo
    Tiffany L Thai
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    Am J Physiol Renal Physiol 295:F360-8. 2008
    ..04 for both) in Sprague-Dawley rats. Mice lacking the predominant form of ADPR cyclase (CD38-/-) had RBF responses to ET-1 that were 47% weaker than those seen in wild-type mice (P = 0.01)...
  74. pmc CD38 plays a dual role in allergen-induced airway hyperresponsiveness
    Fabienne Gally
    Department of Immunology, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 40:433-42. 2009
    The multifunctional surface protein CD38 acts as a receptor with ecto-enzymatic activity, hydrolyzing NAD to generate several products known to exhibit Ca2+-mobilizing properties...
  75. doi Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production
    Yumiko Tsukamoto
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Mol Immunol 46:1278-88. 2009
    IL-4 and 8-mercaptoguanosine (8-SGuo) stimulation of CD38-activated B cells induces mu to gamma1 class switch recombination (CSR) at the DNA level leading to a high level of IgG1 production...
  76. pmc CD38 facilitates recovery from traumatic brain injury
    Ayelet Levy
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    J Neurotrauma 26:1521-33. 2009
    ..TBI is accompanied by neuroinflammation, a process mediated largely by microglia. CD38 is an ectoenzyme that promotes transmembrane signaling via the synthesis of potent calcium mobilizing agents or via ..
  77. doi Activated T-cell-mediated immunotherapy with a chimeric receptor against CD38 in B-cell non-Hodgkin lymphoma
    Keichiro Mihara
    Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami Ku, Hiroshima, Japan
    J Immunother 32:737-43. 2009
    ..b>CD38, highly expressed in B-cell non-Hodgkin lymphoma (B-NHL) cells, is an attractive target in immunotherapy for B-NHL...
  78. doi CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells
    T Vaisitti
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Turin, Italy
    Leukemia 24:958-69. 2010
    ..0002). CD38 expression was the parameter most strongly associated with heightened CXCL12 signaling (P<0...
  79. pmc Generation of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate by CD38 for Ca2+ signaling in interleukin-8-treated lymphokine-activated killer cells
    So Young Rah
    Departments of Biochemistry, Chonbuk National University Medical School, Jeonju 561 182, Republic of Korea
    J Biol Chem 285:21877-87. 2010
    ..In this study we examined the possibility that IL-8 activates CD38 to produce another messenger, nicotinic acid adenine dinucleotide phosphate (NAADP), in LAK cells, and we showed ..
  80. doi Insulin receptor signaling for the proliferation of pancreatic β-cells: involvement of Ca2+ second messengers, IP3, NAADP and cADPR
    Asif Iqbal Shawl
    Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Republic of Korea
    Islets 1:216-23. 2009
    ..Herein, we show the insulin receptor signaling pathway underlying CD38/ADPR-cyclase activation for NAADP/cADPR formation to induce Ca2+ rise, ultimately resulting in β-cell ..
  81. pmc Critical role for CD38-mediated Ca2+ signaling in thrombin-induced procoagulant activity of mouse platelets and hemostasis
    Mazhar Mushtaq
    Department of Biochemistry, Chonbuk National University Medical School, Jeonju 561 182, Korea
    J Biol Chem 286:12952-8. 2011
    b>CD38, a multifunctional enzyme that catalyzes the synthesis of intracellular Ca(2+) messengers, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), is known to be expressed on platelets...
  82. pmc Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice
    Yi Guang Chen
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 186:4278-84. 2011
    ..T1D development was not altered by P2X(7) ablation. Previous studies found CD38 knockout (KO) NOD mice developed accelerated T1D partly because of a loss of CD4(+) invariant NKT (iNKT) cells and ..
  83. pmc The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis
    Shujun Liu
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 6:e17161. 2011
    ..In this report we demonstrated the role of ZAS3 in bone resorption by examining the signaling mechanisms involved in osteoclastogenesis...
  84. pmc The PI3K p110δ regulates expression of CD38 on regulatory T cells
    Daniel T Patton
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    PLoS ONE 6:e17359. 2011
    ..Among the genes that were differentially expressed was the gene for the transmembrane cyclic ADP ribose hydrolase CD38. Here we show that CD38 is expressed mainly by a subset of Foxp3(+)CD25(+)CD4(+) T cells originating in the thymus ..
  85. doi Knocking out of CD38 accelerates development of a lupus-like disease in lpr mice
    Marta S Viegas
    Molecular Pathology Laboratory, Portuguese Institute for Oncology at Coimbra Francisco Gentil, EPE, Av Bissaya Barreto, 98 Apartado 2005, 3000 075 Coimbra, Portugal
    Rheumatology (Oxford) 50:1569-77. 2011
    b>CD38 participates in lymphocyte ontogeny and function and may be involved in autoimmunity. Absence of CD38 accelerates development of non-obese diabetic (NOD) mice diabetes and anti-CD38 antibodies are good markers of human disease...
  86. pmc Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle
    Leonie Durnin
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557 0575, USA
    FEBS J 278:3095-108. 2011
    ..b>CD38 is a multifunctional enzyme involved in the formation of cADPR in mammals...
  87. doi Disruption of CD38 gene enhances cardiac functions by elevating serum testosterone in the male null mice
    Lu Gan
    Laboratory of Cardiovascular Disease, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China
    Life Sci 89:491-7. 2011
    ..Here, we report that cardiac functions are significantly improved only in male CD38-null mice and we explore the potential mechanisms of the sexual dimorphism mediated by CD38 deficiency.
  88. ncbi Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38
    N Harada
    DNAX Research Institute, Palo Alto, CA 94304
    J Immunol 151:3111-8. 1993
    ..and deduced amino acid sequence show approximately 70% homology to the previously reported sequence of human CD38, suggesting that I-19 cDNA encodes either the mouse homologue of CD38 or a closely related protein...
  89. ncbi Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells
    A M Oliver
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham 35294, USA
    J Immunol 158:1108-15. 1997
    ..Human CD38 is highly expressed on both germinal center B cells and plasma cells, and is useful in delineating these B cell ..
  90. ncbi Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac
    M C Yoder
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Immunity 7:335-44. 1997
    ..Surprisingly, 37-fold more CD34+c-Kit+ cells reside in the day 9 yolk sac than in the P-Sp. In sum, definitive HSC are coexistent, but not equal in number, in the murine yolk sac and P-Sp prior to fetal liver colonization...
  91. ncbi Direct interaction of the CD38 cytoplasmic tail and the Lck SH2 domain. Cd38 transduces T cell activation signals through associated Lck
    Y S Cho
    Department of Biochemistry and Institute for Medical Sciences, Chonbuk National University Medical School, Chonju, 561 182 Korea
    J Biol Chem 275:1685-90. 2000
    b>CD38 ligation has been shown to induce activation of intracellular signaling cascade in T lymphocytes through a Lck-dependent pathway. However, it is not clear how Lck initiates the CD38-mediated signaling process...
  92. ncbi Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development
    B Hurle
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    Genomics 77:189-99. 2001
    ..3-p15 region. This analysis identified an inversion between the mouse and human genomes that places tlt and DFNA6/14 in close proximity...
  93. pmc CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain
    Claire Ceni
    Laboratoire Canaux Ioniques et Signalisation, INSERM EMI 9931, DRDC CEA, 17 Avenue des Martyrs, 38051 Grenoble Cedex 9, France
    Biochem J 370:175-83. 2003
    b>CD38 is a transmembrane glycoprotein that is expressed in many tissues throughout the body...
  94. ncbi CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes
    Miguel E Moreno-Garcia
    Departamentos de Biología Celular Biomedicina Molecular, CINVESTAV IPN, Mexico
    Eur J Biochem 271:1025-34. 2004
    b>CD38 is a transmembrane glycoprotein that functions as an ectoenzyme and as a receptor...
  95. ncbi Role of CD38 in myometrial Ca2+ transients: modulation by progesterone
    Michael Thompson
    Dept of Anesthesiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 287:E1142-8. 2004
    ..Here, using a knockout model, we found that the enzyme CD38, responsible for the synthesis of the second messenger cyclic ADP-ribose (cADPR), plays an important role in the ..
  96. ncbi Selective upregulation of the ADP-ribosyl cyclases CD38 and CD157 by TNF but not by RANK-L reveals differences in downstream signaling
    Jameel Iqbal
    Department of Endocrinology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Renal Physiol 291:F557-66. 2006
    ..TNF but not RANK-L led to the sustained upregulation of both CD38 and CD157 as demonstrated by real-time PCR and flow cytometry...
  97. pmc Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis
    Xinhua Yu
    Immunogenetics Group, University of Rostock, Schillingallee, 18055 Rostock, Germany
    Arthritis Res Ther 9:R3. 2007
    ..Of these 117 genes, 21 were located inside the support intervals of the 8 small-effect QTL and thus were considered as candidate genes...
  98. doi Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice
    Hong Xiang Liu
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Neurosci Lett 448:67-70. 2008
    ..The role of CD38 in regulating OT secretion for social behavior has been demonstrated in adult mice, but has not been examined in ..
  99. ncbi Signaling through murine CD38 is impaired in antigen receptor-unresponsive B cells
    F E Lund
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Eur J Immunol 25:1338-45. 1995
    b>CD38 is a 42-kDa membrane associated enzyme which converts NAD into cyclic ADP-ribose (cADPR), a Ca(2+)-mobilizing second messenger, and ADP-ribose (ADPR)...
  100. ncbi CD38 plays a role in effective containment of mycobacteria within granulomata and polarization of Th1 immune responses against Mycobacterium avium
    Marta S Viegas
    Molecular Pathology Laboratory, Portuguese Institute for Oncology of Coimbra IPOCFG, EPE, Av Bissaya Barreto, 98, Apartado 2005, 3000 075 Coimbra, Portugal
    Microbes Infect 9:847-54. 2007
    b>CD38 is a multifunctional ectoenzyme that behaves either as an enzyme, a cell adhesion molecule or as a cell surface receptor involved in cell signalling...
  101. pmc Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes
    Guixiu Shi
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 204:2705-18. 2007
    b>CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than previously appreciated...

Research Grants1

  1. OXYTOCIN AND SOCIAL ATTACHMENT
    Larry Young; Fiscal Year: 2006
    ..The ultimate goal of this research is to provide new approaches to clinical disorders characterized by deficits in attachment, including autism and schizophrenia. ..