Cd207

Summary

Gene Symbol: Cd207
Description: CD207 antigen
Alias: C-type lectin domain family 4 member K, Langerhans cell specific c-type lectin, langerin
Species: mouse

Top Publications

  1. pmc Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions
    Keisuke Nagao
    Dermatology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:3312-7. 2009
  2. pmc Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice
    Christian Wohn
    Department of Immunology, Erasmus MC, University Medical Center, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 110:10723-8. 2013
  3. pmc Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells
    Shamim A Mollah
    Hospital Informatics, Rockefeller University, New York, New York, USA
    J Invest Dermatol 134:1265-75. 2014
  4. pmc Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network
    Laurent Chorro
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunobiology, Infection, and Inflammatory Diseases, King s College London, London SE1 1UL, England, UK
    J Exp Med 206:3089-100. 2009
  5. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
  6. pmc CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
    Sandrine Henri
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    J Exp Med 207:189-206. 2010
  7. pmc Langerin+ dermal DC, but not Langerhans cells, are required for effective CD8-mediated immune responses after skin scarification with vaccinia virus
    Julien Seneschal
    1 Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, Massachusetts, USA 2 Department of Dermatology and Pediatric Dermatology, Inserm U1035, Bordeaux, France
    J Invest Dermatol 134:686-94. 2014
  8. doi Langerhans cells prime IL-17-producing T cells and dampen genital cytotoxic responses following mucosal immunization
    Catherine Hervouet
    Institut National de la Santé et de la Recherche Médicale U634, Faculté de Médecine Pasteur, France
    J Immunol 184:4842-51. 2010
  9. doi The mandatory role of IL-10-producing and OX40 ligand-expressing mature Langerhans cells in local UVB-induced immunosuppression
    Ryutaro Yoshiki
    Department of Dermatology, University of Occupational and Environmental Health, Fukuoka, Japan
    J Immunol 184:5670-7. 2010
  10. pmc Functional redundancy of Langerhans cells and Langerin+ dermal dendritic cells in contact hypersensitivity
    Madelon Noordegraaf
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Invest Dermatol 130:2752-9. 2010

Scientific Experts

  • Magdia De Jesus
  • Elisabeth Riedl
  • Uday K Tirlapur
  • Bjorn E Clausen
  • Bernard Malissen
  • Adrien Kissenpfennig
  • Juliana Idoyaga
  • Florent Ginhoux
  • Daniel H Kaplan
  • Miriam Merad
  • Ralph M Steinman
  • Clare L Bennett
  • Liangchun Wang
  • Sonja P Zahner
  • Patrizia Stoitzner
  • Karina Furmanov
  • Mazal Elnekave
  • Sandrine Henri
  • Botond Z Igyarto
  • Nikolaus Romani
  • Ryutaro Yoshiki
  • Vincent Flacher
  • Moran Arizon
  • Agatha Schwarz
  • Itay Nudel
  • Avi Hai Hovav
  • Madelon Noordegraaf
  • Yosuke Kumamoto
  • Kristin A Hogquist
  • Nicole Amberg
  • Andreas Schlitzer
  • Cheolho Cheong
  • Hiroaki Azukizawa
  • Christoph H Tripp
  • Bart N Lambrecht
  • Kathryn J Farrand
  • Keisuke Nagao
  • Stephen C Jameson
  • Julie Helft
  • Chae Gyu Park
  • Monique A M Willart
  • Lionel Franz Poulin
  • Laura S Bursch
  • Akiko Iwasaki
  • Janneke van Blijswijk
  • Sakeen W Kashem
  • Marija Zaric
  • Marie Luise Berres
  • Ali Zaid
  • Shamim A Mollah
  • Elisabeth Glitzner
  • Julien Seneschal
  • Benjamin Voisin
  • Florian Sparber
  • Matthew Collin
  • Maria Sibilia
  • Boris Reizis
  • Martin Holcmann
  • Beate M Lichtenberger
  • Christian Wohn
  • Pin Xu
  • Nathan E Welty
  • Baalasubramanian Sivasankar
  • Sandra M Zurawski
  • Pierre Guermonprez
  • Gerard Zurawski
  • Adrian W S Ho
  • Maryam Gerami-Nejad
  • Laurent Renia
  • Judith Berman
  • Matheswaran Kandasamy
  • Maud Plantinga
  • Frederic Geissmann
  • Yoshiki Tokura
  • Jyh Hong Lee
  • Ashira Lubkin
  • Barbara Unkel
  • Kazunari Sugita
  • Gwennaelle J Wathne
  • Christopher Fiorese
  • Motonobu Nakamura
  • Pearline Teo
  • Peter See
  • Kenji Kabashima
  • Irlanda Olvera-Gomez
  • Thomas S Kupper
  • Marco Colonna
  • Jeremy Price
  • Asaf Wilensky
  • Martin Guilliams

Detail Information

Publications79

  1. pmc Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions
    Keisuke Nagao
    Dermatology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:3312-7. 2009
    A new langerin(+) DC subset has recently been identified in murine dermis (langerin(+) dDC), but the lineage and functional relationships between these cells and langerin(+) epidermal Langerhans cells (LC) are incompletely characterized...
  2. pmc Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice
    Christian Wohn
    Department of Immunology, Erasmus MC, University Medical Center, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 110:10723-8. 2013
    ..Selective TLR7 triggering of Langerin(+) DCs resulted in attenuated disease, whereas their depletion did not alter the severity of skin lesions...
  3. pmc Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells
    Shamim A Mollah
    Hospital Informatics, Rockefeller University, New York, New York, USA
    J Invest Dermatol 134:1265-75. 2014
    ..Skin DCs carry antigens and constitutively migrate to the skin-draining lymph nodes (LNs). In mice, Langerin-CD11b- dermal DCs are a low-frequency, heterogeneous, migratory DC subset that traffics to LNs (Langerin-CD11b- ..
  4. pmc Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network
    Laurent Chorro
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunobiology, Infection, and Inflammatory Diseases, King s College London, London SE1 1UL, England, UK
    J Exp Med 206:3089-100. 2009
    ..mice around embryonic day 18 and acquired a dendritic morphology, major histocompatibility complex II, CD11c, and langerin expression immediately after birth...
  5. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
    ..Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program...
  6. pmc CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
    Sandrine Henri
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    J Exp Med 207:189-206. 2010
    ..Using knockin mice to track and ablate DCs expressing langerin (CD207), we discovered that the dermis contains five distinct DC subsets and identified their migratory ..
  7. pmc Langerin+ dermal DC, but not Langerhans cells, are required for effective CD8-mediated immune responses after skin scarification with vaccinia virus
    Julien Seneschal
    1 Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, Massachusetts, USA 2 Department of Dermatology and Pediatric Dermatology, Inserm U1035, Bordeaux, France
    J Invest Dermatol 134:686-94. 2014
    ..At least three subsets of skin-resident DC have been identified: Langerhans cells (LCs), dermal Langerin+ DC (Lang+ dDC), and dermal Langerin- DC (Lang- dDC)...
  8. doi Langerhans cells prime IL-17-producing T cells and dampen genital cytotoxic responses following mucosal immunization
    Catherine Hervouet
    Institut National de la Santé et de la Recherche Médicale U634, Faculté de Médecine Pasteur, France
    J Immunol 184:4842-51. 2010
    ..that the vaginal epithelium, unlike the skin epidermis, includes a minor population of LCs and a major subset of langerin(-) DCs...
  9. doi The mandatory role of IL-10-producing and OX40 ligand-expressing mature Langerhans cells in local UVB-induced immunosuppression
    Ryutaro Yoshiki
    Department of Dermatology, University of Occupational and Environmental Health, Fukuoka, Japan
    J Immunol 184:5670-7. 2010
    ..from the UVB-irradiated skin, LCs expressed OX40L as well as CD86 and produced IL-10 at a higher level than Langerin(-) dDCs...
  10. pmc Functional redundancy of Langerhans cells and Langerin+ dermal dendritic cells in contact hypersensitivity
    Madelon Noordegraaf
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Invest Dermatol 130:2752-9. 2010
    ..relative roles of Langerhans cells (LC), dermal dendritic cells (DC), and, in particular, the recently discovered Langerin(+) dermal DC subset in the induction and control of contact hypersensitivity (CHS) responses remain controversial...
  11. ncbi Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues
    Jenny Valladeau
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    J Immunol 168:782-92. 2002
    Human (h)Langerin/CD207 is a C-type lectin of Langerhans cells (LC) that induces the formation of Birbeck granules (BG). In this study, we have cloned a cDNA-encoding mouse (m)Langerin...
  12. pmc IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses
    Andreas Schlitzer
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, 138648 Singapore
    Immunity 38:970-83. 2013
    ....
  13. pmc Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection
    Pierre Guermonprez
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA
    Nat Med 19:730-8. 2013
    ..Our findings highlight a new mechanism that regulates dendritic cell homeostasis and T cell responses to infection...
  14. doi Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen
    Maud Plantinga
    Laboratory of Immunoregulation and Mucosal Immunology, Department for Molecular Biomedical Research, VIB, Ghent 9050, Belgium
    Immunity 38:322-35. 2013
    ..Thus, we have identified migratory CD11b(+) cDCs as the principal subset inducing Th2 cell-mediated immunity in the LN, whereas moDCs orchestrate allergic inflammation in the lung...
  15. pmc Skin langerin+ dendritic cells transport intradermally injected anti-DEC-205 antibodies but are not essential for subsequent cytotoxic CD8+ T cell responses
    Vincent Flacher
    Department of Dermatology and Venereology, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Immunol 188:2146-55. 2012
    ..mAbs against C-type lectins administered intradermally are taken up by epidermal Langerhans cells (LCs), dermal Langerin(neg) DCs, and dermal Langerin(+) DCs in situ...
  16. pmc Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome
    Takeshi Ouchi
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    J Exp Med 208:2607-13. 2011
    ..Targeting this immunological process confers protection with minimal invasiveness and should have a marked impact on future strategies for development of percutaneous vaccines...
  17. doi Conditional deletion of TGF-βR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity
    Sonja P Zahner
    Department of Immunology, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
    J Immunol 187:5069-76. 2011
    ..hand, inducible ablation of LC led to diminished ear swelling, suggesting functional redundancy between LC and (Langerin(+)) dermal dendritic cells (DC)...
  18. pmc Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses
    Botond Z Igyarto
    Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunity 35:260-72. 2011
    ..There are at least three subsets of skin DC- Langerhans cells (LC), Langerin(+) dermal DCs (dDCs), and classic dDCs...
  19. pmc Langerhans cells are negative regulators of the anti-Leishmania response
    Kordula Kautz-Neu
    Department of Dermatology, Johannes Gutenberg University, 55131 Mainz, Germany
    J Exp Med 208:885-91. 2011
    ..In this study, we analyzed the role of Langerin(+) skin-derived DCs in the Leishmania model using inducible in vivo cell ablation...
  20. ncbi Priming of CD8+ and CD4+ T cells in experimental leishmaniasis is initiated by different dendritic cell subtypes
    Nancy Brewig
    Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Immunol 182:774-83. 2009
    The biological role of Langerin+ dendritic cells (DCs) such as Langerhans cells and a subset of dermal DCs (dDCs) in adaptive immunity against cutaneous pathogens remains enigmatic...
  21. pmc Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:1524-9. 2009
    ..Here, we used a new antibody to Langerin/CD207, which colabels isolated CD8(+) CD205(+) DCs, to immunolabel spleen sections...
  22. ncbi Identification and expression of mouse Langerin (CD207) in dendritic cells
    Kazuhiko Takahara
    Laboratory of Immunobiology, Department of Animal Development and Physiology, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, 606 8502, Japan
    Int Immunol 14:433-44. 2002
    We have cloned the mouse homologue of human Langerin (h-Langerin), a type II transmembrane protein with a single external C-type lectin domain...
  23. ncbi Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
    J Valladeau
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Immunity 12:71-81. 2000
    ..lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin. LC are uniquely characterized by Birbeck granules (BG), which are organelles consisting of superimposed and ..
  24. pmc Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells
    Corine H GeurtsvanKessel
    Department of Pulmonary Medicine, Erasmus University Medical Centre Rotterdam, 3015 GE Rotterdam, Netherlands
    J Exp Med 205:1621-34. 2008
    ..When lung CD11chi DCs and macrophages or langerin+CD11b-CD11chi DCs were depleted using either CD11c-diphtheria toxin receptor (DTR) or langerin-DTR mice, the ..
  25. ncbi Langerin expressing cells promote skin immune responses under defined conditions
    Liangchun Wang
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 180:4722-7. 2008
    ..Finally we show that conditions which eliminate epidermal LC but spare other Langerin(+) DC do not impair the epicutaneous immunization response to OVA...
  26. pmc Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique de Luminy, Marseille, France
    Mol Cell Biol 25:88-99. 2005
    b>Langerin is a C-type lectin expressed by a subset of dendritic leukocytes, the Langerhans cells (LC). Langerin is a cell surface receptor that induces the formation of an LC-specific organelle, the Birbeck granule (BG)...
  27. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
    ..Unlike epidermal LCs, dermal Langerin(+) dendritic cells (DCs) were radiosensitive and displayed a distinct cell surface phenotype...
  28. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
    ..in vivo, we developed knockin mice expressing enhanced green fluorescent protein (EGFP) under the control of the langerin (CD207) gene...
  29. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    b>Langerin is a C-type lectin receptor that recognizes glycosylated patterns on pathogens...
  30. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
    ..Within 24 h after intra-peritoneal injection of DT into Langerin-DTR mice LC are completely depleted from the epidermis and only begin to return 4 wk later...
  31. pmc The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells
    Lionel Franz Poulin
    Centre d immunologie de Marseille Luminy, Universite de la Mediterrannee, Case 906, 13288 Marseille Cedex 9, France
    J Exp Med 204:3119-31. 2007
    Langerhans cells (LCs) constitute a subset of dendritic cells (DCs) that express the lectin langerin and that reside in their immature state in epidermis...
  32. pmc CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens
    Yosuke Kumamoto
    Department of Immunobiology, Yale University School of Medicine, New Haven, United States
    elife 5:. 2016
    ..Transient depletion of CD301b+ DC results in the generation of autoreactive IgG responses. These results revealed a novel regulatory mechanism and a key role of CD301b+ DCs in blocking autoantibody generation...
  33. pmc Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation
    Sakeen W Kashem
    Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunity 42:356-66. 2015
    ..These findings provide insight into compartmentalization of Th cell responses and C. albicans pathogenesis and have critical implications for vaccine strategies...
  34. pmc Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells
    Janneke van Blijswijk
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3LY, United Kingdom
    J Immunol 194:307-15. 2015
    ..It further indicates that DTR, a member of the epidermal growth factor family, is biologically active in mice. Its use in cell ablation experiments needs to be considered in light of this activity. ..
  35. doi Dissolving microneedle delivery of nanoparticle-encapsulated antigen elicits efficient cross-priming and Th1 immune responses by murine Langerhans cells
    Marija Zaric
    The Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, UK
    J Invest Dermatol 135:425-34. 2015
    ....
  36. doi Epidermal EGFR controls cutaneous host defense and prevents inflammation
    Beate M Lichtenberger
    Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Austria
    Sci Transl Med 5:199ra111. 2013
    ....
  37. pmc Specific roles for dendritic cell subsets during initiation and progression of psoriasis
    Elisabeth Glitzner
    Department of Medicine I, Comprehensive Cancer Center Institute of Cancer Research Medical University of Vienna, Vienna, Austria
    EMBO Mol Med 6:1312-27. 2014
    ..In contrast, while depletion of Langerin-expressing APCs before disease onset had no effect, depletion from diseased mice aggravated psoriasis symptoms...
  38. pmc Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism
    Nathan E Welty
    Department of Dermatology, Center for Immunology and 2 Department of Soil, Water, and Climate, Biotechnology Institute, University of Minnesota, Minneapolis, MN 55455
    J Exp Med 210:2011-24. 2013
    ..We report here that Langerin is expressed by human LP DCs and that transgenic human langerin drives expression in CD103(+)CD11b(+) LP DCs in ..
  39. pmc The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis
    Florian Sparber
    Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria
    Blood 123:217-27. 2014
    ..Hence, we conclude that p14 acts as a novel and essential regulator of LC homeostasis in vivo. ..
  40. pmc Persistence of skin-resident memory T cells within an epidermal niche
    Ali Zaid
    Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3010, Australia
    Proc Natl Acad Sci U S A 111:5307-12. 2014
    ..Together, these data suggest that skin tissue-resident memory T cells persist within a tightly regulated epidermal T-cell niche. ..
  41. pmc BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups
    Marie Luise Berres
    Department of Oncological Sciences, 2 Tisch Cancer Institute, and 3 Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029
    J Exp Med 211:669-83. 2014
    ..Langerhans cell histiocytosis (LCH) is a clonal disorder with elusive etiology, characterized by the accumulation of CD207(+) dendritic cells (DCs) in inflammatory lesions. Recurrent BRAF-V600E mutations have been reported in LCH...
  42. doi IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing γδ T cells
    Ryutaro Yoshiki
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Invest Dermatol 134:1912-21. 2014
    ..LC depletion by means of diphtheria toxin (DT) in Langerin DT receptor-knocked-in mice suppressed hyperkeratosis, parakeratosis, and ear swelling in the IMQ-treated regions...
  43. doi Anatomical distribution analysis reveals lack of Langerin+ dermal dendritic cells in footpads and tail of C57BL/6 mice
    Benjamin Voisin
    Laboratory of Immunopathology and Therapeutic Chemistry Laboratory of Excellence Medalis, CNRS UPR3572, Institut de Biologie Moleculaire et Cellulaire, University of Strasbourg, Strasbourg, France
    Exp Dermatol 23:354-6. 2014
    ..The function of LCs and Langerin+ dDCs was extensively studied in the mouse, but their anatomical repartition is unknown...
  44. pmc A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles
    Magdia De Jesus
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
    PLoS ONE 9:e91002. 2014
    ..to be expressed by leukocytes within the intestinal mucosa revealed that GP-containing SED DCs were positive for Langerin (CD207), a CLR with specificity for β-D-glucan and that has been shown to mediate the internalization of a wide ..
  45. doi Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens
    Kathryn J Farrand
    Malaghan Institute of Medical Research, Wellington, New Zealand
    J Immunol 183:7732-42. 2009
    ..As a proportion of CD8alpha(+) DC have been shown to express langerin (CD207), we investigated the role of langerin(+)CD8alpha(+) DC in presenting Ag and priming T cell responses to ..
  46. doi Aryl hydrocarbon receptor is critical for homeostasis of invariant gammadelta T cells in the murine epidermis
    Stephanie Kadow
    Molecular Immunology, Leibniz Research Institute for Environmental Medicine, 40225 Dusseldorf, Germany
    J Immunol 187:3104-10. 2011
    ..Our findings suggest that the DETCs are necessary for LC maturation, and provide insights into a novel role for AhR in the maintenance of skin-specific γδ T cells, and its consequences for the skin immune network...
  47. pmc Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice
    Pin Xu
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 110:10759-64. 2013
    ..Our findings offer insights into the pathophysiology and treatment of both compulsive behavior and eating disorders. ..
  48. pmc Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination
    Irlanda Olvera-Gomez
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis MN 55414, USA
    Proc Natl Acad Sci U S A 109:2072-7. 2012
    ..of classic toll-like receptor (TLR) and inflammasome pathways and, surprisingly, is independent of skin langerin-expressing cells (including Langerhans cells)...
  49. doi Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin
    Gwennaelle J Wathne
    University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    J Leukoc Biol 91:817-28. 2012
    ..Here, transgenic mice were used, in which langerin(+) cells, including epidermal LCs and langerin(+) classical DCs, were specifically depleted...
  50. pmc Langerhans cells down-regulate inflammation-driven alveolar bone loss
    Moran Arizon
    Institute of Dental Sciences, Hebrew University Hadassah School of Dental Medicine, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 109:7043-8. 2012
    ....
  51. doi 1,25-dihydroxyvitamin D exerts similar immunosuppressive effects as UVR but is dispensable for local UVR-induced immunosuppression
    Agatha Schwarz
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Invest Dermatol 132:2762-9. 2012
    ..Using Langerin-DTR (DT receptor) knock-in mice, it was shown that Langerhans cells (LCs) are required for the induction of Tregs ..
  52. pmc Alveolar epithelial cells orchestrate DC function in murine viral pneumonia
    Barbara Unkel
    Department of Internal Medicine II, University of Giessen and Marburg Lung Center, Giessen, Germany
    J Clin Invest 122:3652-64. 2012
    ....
  53. doi Evaluation of the role of CD207 on Langerhans cells in a murine model of atopic dermatitis by in situ imaging using Cr:forsterite laser-based multimodality nonlinear microscopy
    Jyh Hong Lee
    National Taiwan University Hospital and National Taiwan University College of Medicine, Department of Pediatrics, Taipei, 10002, Taiwan
    J Biomed Opt 17:116007. 2012
    Atopic dermatitis (AD) is an allergic inflammatory disease of skin. It remains unclear that CD207 of Langerhans cells (LCs) plays a central role in the development of allergic sensitization...
  54. pmc Specialized role of migratory dendritic cells in peripheral tolerance induction
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, USA
    J Clin Invest 123:844-54. 2013
    ..These results provide a rationale for the development of novel therapies targeting migratory DCs for the treatment of autoimmune diseases...
  55. pmc Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection
    Matheswaran Kandasamy
    Infection and Immunity Programme, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research ASTAR, Singapore
    PLoS Pathog 9:e1003115. 2013
    ..Collectively, our findings show that complement has a profound impact on immune regulation by controlling tissue DC trafficking and highlights a potential utility for complement as an adjuvant in novel vaccine strategies...
  56. doi Langerhans cells are required for UVR-induced immunosuppression
    Agatha Schwarz
    Department of Dermatology, University Kiel, Kiel, Germany
    J Invest Dermatol 130:1419-27. 2010
    ..Accordingly, the steroid mometasone, which kills LCs, inhibited sensitization but did not induce Treg. In Langerin-diphtheria toxin receptor knock-in (DTR) mice, LCs can be depleted by injection of diphtheria toxin (DT)...
  57. pmc Langerhans cells serve as immunoregulatory cells by activating NKT cells
    Atsushi Fukunaga
    Department of Immunology, Center for Cancer Immunology Research, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 185:4633-40. 2010
    ..Our findings indicate that UV exposure activates the migration of mature LC to the skin draining LNs, where they induce immune regulation in vivo by activating NKT cells...
  58. pmc The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen
    Monique A M Willart
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University of Ghent, Ghent B 9000, Belgium
    J Exp Med 206:2823-35. 2009
    ..We conclude that the lung vascular filter represents a largely unexplored site of immune induction that traps large bloodborne Ags for presentation by monocyte-derived DCs...
  59. pmc Epidermal Langerhans cells are not required for UV-induced immunosuppression
    Liangchun Wang
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:5548-53. 2009
    ..Our previous studies identified a novel langerin(+) dendritic cell in the dermis, distinct from LC in phenotype, circulation, and function...
  60. pmc Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice
    Teresa Bianchi
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 182:4665-74. 2009
    ..responsible for Ag presentation in vivo and induce tolerance to skin Ags, as we show by selective depletion of langerin(+) and CD11c(+) dendritic cells...
  61. ncbi Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk
    Sun Young Chang
    Mucosal Immunology Section, International Vaccine Institute, Seoul, Republic of Korea
    J Immunol 180:4361-5. 2008
    ..The mesenteric lymph node (MLN) was shown to be the site of IgA isotype class switching after TCI. Unexpectedly, langerin(+)CD8alpha(-) dendritic cells emerged in the MLN after TCI; they did not migrate from the skin but rather ..
  62. ncbi Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    J Immunol 180:3647-50. 2008
    ..To evaluate the function of Langerin/CD207, a receptor expressed by subsets of DCs that frequently coexpress the DEC205/CD205 receptor, we genetically ..
  63. ncbi Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes
    Lisa A Nichols
    Department of Microbiology and Carter Immunology Center, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Immunol 179:993-1003. 2007
    ..This suggests that direct presentation of tyrosinase by radio-resistant lymph node resident cells is entirely responsible for tolerance to this endogenous melanocyte differentiation Ag...
  64. ncbi Femtosecond two-photon high-resolution 3D imaging, spatial-volume rendering and microspectral characterization of immunolocalized MHC-II and mLangerin/CD207 antigens in the mouse epidermis
    Uday K Tirlapur
    Department of Engineering Science, Oxford Institute of Biomedical Engineering, University of Oxford, Oxford OX1 3PJ, United Kingdom
    Microsc Res Tech 69:767-75. 2006
    ..II (MHC-II) molecules and CD1a, intracellular presence of racket-shaped "Birbeck granules," and very recently Langerin/CD207, LCs can be readily distinguished from other subsets of dendritic cells...
  65. ncbi Identification and characterization of endogenous Langerin ligands in murine extracellular matrix
    Yayoi Tada
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Massachusetts, USA
    J Invest Dermatol 126:1549-58. 2006
    b>Langerin is a C-type lectin that is expressed by Langerhans cells (LC) and related immune cells, and believed to play an important role in antigen recognition and uptake...
  66. ncbi Identification and characterization of an alternatively spliced isoform of mouse Langerin/CD207
    Elisabeth Riedl
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Invest Dermatol 123:78-86. 2004
    The mouse homologue of human Langerin (CD207), a novel Langerhans cells (LC)-restricted C-type lectin that likely participates in antigen recognition and uptake, has been recently identified...
  67. pmc Retinoids regulate survival and antigen presentation by immature dendritic cells
    Frederic Geissmann
    UPRES EA 219 Service d Anatomie Pathologique EA 219, Hopital Necker Enfants Malades, 161 rue de Sevres, 75743 Paris Cedex 15, France
    J Exp Med 198:623-34. 2003
    ..We identify a novel cellular function for retinoids and suggest that selective retinoids might be of interest for controlling antigen presentation...
  68. pmc Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
    Clementine Schilte
    Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 207:429-42. 2010
    ..This study defines an essential role for type I IFN, produced via cooperation between multiple host sensors and acting directly on nonhematopoietic cells, in the control of CHIKV...
  69. doi The role of skin-derived dendritic cells in CD8+ T cell priming following immunization with lentivectors
    Karina Furmanov
    Institute of Dental Sciences, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel
    J Immunol 184:4889-97. 2010
    ..Using langerin-diphtheria toxin receptor transgenic mice we demonstrated that ablation of langerhans cells and langerin-..
  70. doi Directly transfected langerin+ dermal dendritic cells potentiate CD8+ T cell responses following intradermal plasmid DNA immunization
    Mazal Elnekave
    Institute of Dental Sciences, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel
    J Immunol 185:3463-71. 2010
    ..Using langerin- diphtheria toxin receptor mice we demonstrated that langerin(+) dermal DCs (Ln(+) dDCs) were crucial for ..
  71. pmc Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes
    R K Subbarao Malireddi
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    J Immunol 185:3127-30. 2010
    ..Thus, protease-mediated inactivation of PARP1 is a shared feature of apoptotic, necrotic, and pyroptotic cells...
  72. pmc Langerhans cells are not required for epidermal Vgamma3 T cell homeostasis and function
    Sylvie Taveirne
    Microbiology and Immunology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
    J Leukoc Biol 90:61-8. 2011
    ..Additionally, in vivo skin-wounding experiments show no major difference in response of Vγ3 T cells to wounding in the absence or presence of LCs. These observations indicate that Vγ3 T cells develop and function independently of LCs...
  73. doi Dendritic cells in distinct oral mucosal tissues engage different mechanisms to prime CD8+ T cells
    Itay Nudel
    Institute of Dental Sciences, Hebrew University Hadassah School of Dental Medicine, Jerusalem 91120, Israel
    J Immunol 186:891-900. 2011
    ..subset expressing the CD103(+) molecule, which represents an uncharacterized subset of oral iDCs expressing the langerin receptor (Ln(+)iDCs)...
  74. pmc Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology and the Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:2384-9. 2011
    ..Here, we compared the capacity of Langerin/CD207, DEC205/CD205, and Clec9A receptors, each expressed on the CD8(+) DC subset in mice, to bring about ..
  75. doi Administration of alpha-galactosylceramide impairs the survival of dendritic cell subpopulations in vivo
    Helen M A Simkins
    Malaghan Institute of Medical Research, Victoria University, Wellington, New Zealand
    J Leukoc Biol 89:753-62. 2011
    ..We report that i.v. injection of α-GalCer induced a decrease in the percentage and number of splenic CD8(+)Langerin(+) DCs, while CD8(-) DCs were not affected...
  76. pmc Conventional dendritic cells are required for the activation of helper-dependent CD8 T cell responses to a model antigen after cutaneous vaccination with lentiviral vectors
    Hugh D Goold
    Division of Cancer Studies, Department of Haematology, University College London, Royal Free Campus, London NW3 2PF, United Kingdom
    J Immunol 186:4565-72. 2011
    ....
  77. doi Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells
    Hiroaki Azukizawa
    Department of Dermatology, University Hospital Erlangen, Erlangen, Germany
    Eur J Immunol 41:1420-34. 2011
    ..The langerin(+) dermal DC subset, but not epidermal Langerhans cells, mediated conversion of naive OT-II×RAG-1(-/-) T cells ..
  78. pmc Characterization of Langerin-expressing dendritic cell subsets in the normal cornea
    Takaaki Hattori
    Schepens Eye Research Institute, Boston, Massachusetts 02117, USA
    Invest Ophthalmol Vis Sci 52:4598-604. 2011
    In addition to Langerhans cells (LCs), other dendritic cells (CD11c(+)) have recently been shown to express Langerin (c-type lectin). In skin, (non-LC) Langerin+ dendritic cells initiate adaptive immunity...
  79. pmc The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells
    Hervé Luche
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Eur J Immunol 41:2165-75. 2011
    ..However, in the thymus a major subset of DCs expressing CD8α and langerin (CD207) appears to stand apart from all other DCs in that it is thought to derive from progenitors with lymphoid ..