Cd1d1

Summary

Gene Symbol: Cd1d1
Description: CD1d1 antigen
Alias: AI747460, CD1.1, Cd1a, Cd1d, Ly-38, antigen-presenting glycoprotein CD1d1, T-cell surface glycoprotein CD1d1
Species: mouse

Top Publications

  1. pmc Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
    Frederic Sierro
    Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:14759-64. 2007
  2. pmc Characterization of the early stages of thymic NKT cell development
    Kamel Benlagha
    Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 202:485-92. 2005
  3. pmc Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product
    Benoit Pasquier
    Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Unité INSERM 429
    J Exp Med 201:695-701. 2005
  4. pmc Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation
    Jin S Im
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Immunity 30:888-98. 2009
  5. ncbi Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids
    Christophe Paget
    Institut National de la Recherche Médicale, U547, 59019 Lille, France
    Immunity 27:597-609. 2007
  6. pmc A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d
    Yuval Sagiv
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 204:921-8. 2007
  7. pmc CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes
    Patricia Barral
    Lymphocyte Interaction Laboratory, Cancer Research UK, London Research Institute, London, UK
    Nat Immunol 11:303-12. 2010
  8. pmc Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma
    Ji Hyung Kim
    Department of Pathology and Laboratory of Immune Regulation in Graduate Program for Immunology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 799, Korea
    Am J Pathol 167:1231-41. 2005
  9. ncbi IL-4-secreting NKT cells prevent hypersensitivity pneumonitis by suppressing IFN-gamma-producing neutrophils
    Su Jin Hwang
    Department of Pathology, Graduate Program of Immunology, Seoul National University College of Medicine, Seoul, Korea
    J Immunol 177:5258-68. 2006
  10. pmc Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma
    Gourapura J Renukaradhya
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Blood 111:5637-45. 2008

Research Grants

  1. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
  2. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
  3. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
  4. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
  5. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
  6. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
  7. TREATMENT OF TUBERCULOSIS WITH IMMUNOMODULATORS
    Samuel Behar; Fiscal Year: 2003
  8. Antigen-specific CD8+ T cells and protective immunity to tuberculosis
    Samuel M Behar; Fiscal Year: 2010
  9. CDI Molecules & NKT Cells in Host Defense
    RANDY BRUTKIEWICZ; Fiscal Year: 2009
  10. TREATMENT OF TUBERCULOSIS WITH IMMUNOMODULATORS
    Samuel Behar; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. pmc Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
    Frederic Sierro
    Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:14759-64. 2007
    ..Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4...
  2. pmc Characterization of the early stages of thymic NKT cell development
    Kamel Benlagha
    Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 202:485-92. 2005
    Upon reaching the mature heat stable antigen (HSA)low thymic developmental stage, CD1d-restricted Valpha14-Jalpha18 thymocytes undergo a well-characterized sequence of expansion and differentiation steps that lead to the peripheral ..
  3. pmc Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product
    Benoit Pasquier
    Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Unité INSERM 429
    J Exp Med 201:695-701. 2005
    ..They also identify for the first time a defect in NKT cells associated with a human primary immunodeficiency, revealing a potential role of NKT cells in the immune response to EBV...
  4. pmc Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation
    Jin S Im
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Immunity 30:888-98. 2009
    b>CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines...
  5. ncbi Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids
    Christophe Paget
    Institut National de la Recherche Médicale, U547, 59019 Lille, France
    Immunity 27:597-609. 2007
    ..natural killer T (iNKT) cells are a subset of innate lymphocytes that recognize lipid antigens in the context of CD1d and mediate potent immune regulatory functions via the rapid production of interferon-gamma (IFN-gamma) and ..
  6. pmc A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d
    Yuval Sagiv
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 204:921-8. 2007
    ..was recently suggested to directly regulate the biosynthesis of the MHC I-like, lipid antigen presenting molecule CD1d, based on coprecipitation experiments and lipid loading assays...
  7. pmc CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes
    Patricia Barral
    Lymphocyte Interaction Laboratory, Cancer Research UK, London Research Institute, London, UK
    Nat Immunol 11:303-12. 2010
    ..Although it is known that iNKT cells recognize glycolipids presented by CD1d, how and where they encounter antigen in vivo remains unclear...
  8. pmc Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma
    Ji Hyung Kim
    Department of Pathology and Laboratory of Immune Regulation in Graduate Program for Immunology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 799, Korea
    Am J Pathol 167:1231-41. 2005
    ..bleomycin, and blockade of TGF-beta1 by neutralizing monoclonal antibody attenuated the pulmonary fibrosis in CD1d-/- mice. In contrast, the production of IFN-gamma was reduced in lungs from CD1d-/- mice...
  9. ncbi IL-4-secreting NKT cells prevent hypersensitivity pneumonitis by suppressing IFN-gamma-producing neutrophils
    Su Jin Hwang
    Department of Pathology, Graduate Program of Immunology, Seoul National University College of Medicine, Seoul, Korea
    J Immunol 177:5258-68. 2006
    ..In CD1d(-/-) mice, the HP was worse in terms of histological changes, hydroxyproline levels, the CD4:CD8 ratio in ..
  10. pmc Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma
    Gourapura J Renukaradhya
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Blood 111:5637-45. 2008
    Natural killer T (NKT) cells are a T-cell subpopulation known to possess immunoregulatory functions and recognize CD1d molecules...
  11. pmc The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
    Yasutaka Motomura
    Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan
    Nat Immunol 12:450-9. 2011
    ..Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T(H)1 cells and IL-10 in T(H)1 cells, T(H)2 cells, T(reg) cells and NKT cells...
  12. doi Mutation of a positively charged cytoplasmic motif within CD1d results in multiple defects in antigen presentation to NKT cells
    Jung Hoon Shin
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    J Immunol 188:2235-43. 2012
    b>CD1d is an MHC class I-like molecule that presents glycolipid Ags to types I and II NKT cells...
  13. ncbi Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression
    Jan Novak
    Institut National de la Santé et de la Recherche Médicale Unité 561, University René Descartes Hôpital Cochin Saint Vincent de Paul, Paris, France
    J Immunol 178:1332-40. 2007
    ..The present study was designed to determine whether the CD1d molecule is involved in the inhibitory function of iNKT cells...
  14. doi Regulation of secondary antigen-specific CD8(+) T-cell responses by natural killer T cells
    Changwan Hong
    School of Life Sciences and Biotechnology, Korea University, Sungbukku Anamdong, Seoul, Korea
    Cancer Res 69:4301-8. 2009
    ..Taken together, our findings strongly emphasize the importance of NKT cells in secondary CD8(+) T-cell immune responses...
  15. doi T cell Ig domain and mucin domain 1 engagement on invariant NKT cells in the presence of TCR stimulation enhances IL-4 production but inhibits IFN-gamma production
    Hye Sung Kim
    Department of Pathology, SeoulNational University College of Medicine, Seoul, Korea
    J Immunol 184:4095-106. 2010
    ..We found that mouse NK1.1(+)TCR-beta(+), alpha-galactosyl ceramide/CD1d dimer(+) NKT, and NKT hybridoma (DN32.D3) cells constitutively express TIM1 and TIM4 on their surface...
  16. pmc Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes
    Datsen G Wei
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 202:239-48. 2005
    ..After positive selection mediated by CD1d-expressing cortical thymocytes, the mature NKT cell lineage undergoes a series of changes suggesting antigen ..
  17. pmc Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity
    Dirk M Zajonc
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 202:1517-26. 2005
    Sulfatide derived from the myelin stimulates a distinct population of CD1d-restricted natural killer T (NKT) cells...
  18. pmc Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation
    Courtney M Lappas
    Department of Pharmacology, University of Virginia, Charlottesville, VA 2290, USA
    J Exp Med 203:2639-48. 2006
    ..1-positive cells (NK and NKT) or to block CD1d-mediated glycolipid presentation to NKT cells replicates, but is not additive to, the protection afforded by ..
  19. ncbi Cross-regulation between type I and type II NKT cells in regulating tumor immunity: a new immunoregulatory axis
    Elena Ambrosino
    National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 179:5126-36. 2007
    ..Alteration of the balance between the protective type I and the suppressive type II NKT cell may be exploited for therapeutic intervention in cancer...
  20. pmc NK T cells provide lipid antigen-specific cognate help for B cells
    Elizabeth A Leadbetter
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:8339-44. 2008
    ..This B cell response is absent in CD1d(-/-) and Jalpha18(-/-) mice but not CD4(-/-) mice...
  21. ncbi Interplay of cytokines and microbial signals in regulation of CD1d expression and NKT cell activation
    Markus Sköld
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 175:3584-93. 2005
    In this study we show that like MHC class I and class II molecules, cell surface CD1d expression on APC is regulated and affects T cell activation under physiological conditions...
  22. ncbi CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4
    S K Mendiratta
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Immunity 6:469-77. 1997
    ..We have generated mice that carry a mutant CD1d1 gene. NT cell numbers in the thymus, spleen, and liver of these mice were dramatically reduced...
  23. pmc Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17
    Muriel Pichavant
    Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:385-93. 2008
    ..Surprisingly, NKT cell-deficient (CD1d(-/-) and Jalpha18(-/-)) mice failed to develop ozone-induced AHR...
  24. ncbi CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung
    Edward E S Nieuwenhuis
    Gastroenterology Division and Laboratory of Mucosal Immunology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 8:588-93. 2002
    b>CD1d-restricted T cells are implicated as key players in host defense against various microbial infections...
  25. ncbi Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors
    Manfred Brigl
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
    J Immunol 176:3625-34. 2006
    b>CD1d-restricted NKT cells use structurally conserved TCRs and recognize both self and foreign glycolipids, but the TCR features that determine these Ag specificities remain unclear...
  26. pmc Rapid and reliable generation of invariant natural killer T-cell lines in vitro
    Asako Chiba
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunology 128:324-33. 2009
    Several tools have proved useful in the study of invariant natural killer T (iNKT) cells, including CD1d-deficient mice, J alpha281-deficient mice, synthetic lipid antigens and antigen-loaded CD1d tetramers...
  27. pmc Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids
    Bo Pei
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 186:1348-60. 2011
    ..The development and activation of iNKT cells is dependent on self-Ags presented by the CD1d Ag-presenting molecule...
  28. ncbi Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis
    Jun Qi Yang
    Department of Internal Medicine, Autoimmunity and Tolerance Laboratory, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 171:2142-53. 2003
    ..Humans and mice with SLE have reduced numbers of CD1d-restricted NK T cells, suggesting a role for these cells in the regulation of SLE...
  29. doi IL-12p35 promotes antibody-induced joint inflammation by activating NKT cells and suppressing TGF-beta
    Yuna Park
    Department of Pathology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Seoul, South Korea
    J Immunol 185:1476-84. 2010
    ....
  30. ncbi A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung
    C D D'Souza
    Mycobacterial Research Laboratories, Departments of Microbiology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    Am J Respir Cell Mol Biol 23:188-93. 2000
    ....
  31. ncbi CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo
    E Assarsson
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    J Immunol 165:3673-9. 2000
    ..1+TCRalphabeta+ cells within lymphokine-activated killer cell cultures from wild-type C57BL/6, CD1d1-/-, and Jalpha281-/- mice that lack classical NKT cells. Unlike classical NKT cells, 50-60% of these NK1...
  32. pmc The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families
    S H Park
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Exp Med 193:893-904. 2001
    To define the phenotype and T cell receptor (TCR) repertoire of CD1d-dependent T cells, we compared the populations of T cells that persisted in major histocompatibility complex (MHC)-deficient mice, which lack mainstream T cells, with ..
  33. ncbi Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d
    Ya Hui Chiu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Nat Immunol 3:55-60. 2002
    ..the germ line, and through homologous recombination in embryonic stem cells, we now describe knock-in mice with the CD1d cytoplasmic tail deleted...
  34. ncbi CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain
    J Jayawardena-Wolf
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Immunity 15:897-908. 2001
    ..We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs ..
  35. pmc Innate immune response to encephalomyocarditis virus infection mediated by CD1d
    Mark A Exley
    Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Immunology 110:519-26. 2003
    b>CD1d-reactive natural killer T (NKT) cells can rapidly produce T helper type 1 (Th1) and/or Th2 cytokines, can activate antigen-presenting cell (APC) interleukin-12 (IL-12) production, and are implicated in the regulation of adaptive ..
  36. pmc Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins
    Dapeng Zhou
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Science 303:523-7. 2004
    ..in prosaposin, the precursor to a family of endosomal lipid transfer proteins (LTP), exhibit specific defects in CD1d-mediated antigen presentation and lack Valpha14 NKT cells...
  37. pmc Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells
    Karsten Fischer
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 101:10685-90. 2004
    A group of T cells recognizes glycolipids presented by molecules of the CD1 family. The CD1d-restricted natural killer T cells (NKT cells) are primarily considered to be self-reactive...
  38. ncbi Lipid rafts are required for efficient signal transduction by CD1d
    Yoon Kyung Park
    Graduate School of Life Sciences and Biotechnology, Korea University, Anam Dong, Sungbuk Ku, Seoul 136 701, Republic of Korea
    Biochem Biophys Res Commun 327:1143-54. 2005
    ..b>CD1d is a conserved family of major histocompatibility class I-like molecules, which has been established as an ..
  39. ncbi NKT cells are not critical for HSV-1 disease resolution
    Ann L Cornish
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australia
    Immunol Cell Biol 84:13-9. 2006
    ..In contrast to conventional T cells, NKT cells express an invariant TCR and respond to glycolipids presented by CD1d. In this study, we sought to investigate the role of NKT cells in regulating the response to infection with HSV-1, ..
  40. ncbi Sensitivity of NK1.1-negative NKT cells to transgenic BATF defines a role for activator protein-1 in the expansion and maturation of immature NKT cells in the thymus
    Alfred J Zullo
    Department of Biological Sciences and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 178:58-66. 2007
    ..This study is the first to characterize AP-1 activity in NKT cells and implicates the integrity of this transcription factor complex in developmental events essential to the establishment of this unique T cell subset in the thymus...
  41. ncbi Ito cells are liver-resident antigen-presenting cells for activating T cell responses
    Florian Winau
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Immunity 26:117-29. 2007
    ....
  42. pmc Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease
    Ramesh C Halder
    Laboratory of Autoimmunity, Torrey Pines Institute for Molecular Studies, San Diego, California 92121, USA
    J Clin Invest 117:2302-12. 2007
    ..subsequent immune regulatory mechanism following recognition of sulfatide, a self-glycolipid ligand for a subset of CD1d-restricted type II NKT cells...
  43. ncbi Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development
    Elizabeth Hager
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Science Center, Denver, CO 80206, USA
    J Immunol 179:2228-34. 2007
    b>CD1d-restricted NKT cells that express an invariant Valpha14 TCR represent a subset of T cells implicated in the regulation of several immune responses, including autoimmunity, infectious disease, and cancer...
  44. pmc Widespread natural variation in murine natural killer T-cell number and function
    Stacia L Rymarchyk
    Department of Surgery, Univeristy of Vermont College of Medicine, Burlington, VT 05405, USA
    Immunology 125:331-43. 2008
    ....
  45. pmc IL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cells
    Masaki Terabe
    Vaccine Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20893, USA
    J Immunol 180:7276-86. 2008
    Despite recent gains in knowledge regarding CD1d-restricted NKT cells, very little is understood of non-CD1d-restricted NKT cells such as CD8(+)NK1.1(+) T cells, in part because of the very small proportion of these cells in the periphery...
  46. pmc Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals
    Aaron J Tyznik
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 181:4452-6. 2008
    ..This requires TLR9 signaling and IL-12 secretion by the activated DCs, but it does not require CD1d expression. iNKT cells also produce IFN-gamma in response to mouse CMV infection...
  47. pmc Non-classical natural killer T cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d
    Ralf Geiben-Lynn
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 284:33800-6. 2009
    ..that antigen expression is modified by type II NKT cells, after interaction with a beta2-microglobulin-independent CD1d receptor...
  48. pmc Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells
    Jing Wang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:1535-40. 2010
    Invariant natural killer T cells (iNKT cells) respond to CD1d-presented glycolipids from Borrelia burgdorferi, the causative agent of Lyme disease...
  49. ncbi Isolation and expression of cDNA encoding the murine homologues of CD1
    S P Balk
    Laboratory of Molecular Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 146:768-74. 1991
    ..These results demonstrate that the murine and human CD1 genes, although encoding homologous transmembrane glycoproteins, are expressed in distinct tissues and may serve different functions...
  50. ncbi CD1 recognition by mouse NK1+ T lymphocytes
    A Bendelac
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    Science 268:863-5. 1995
    ..This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells...
  51. ncbi Peptide binding and presentation by mouse CD1
    A R Castaño
    Department of Immunology, La Jolla, CA 92037, USA
    Science 269:223-6. 1995
    ..Peptide-specific, mCD1-restricted T cell responses can be raised, which suggests that the findings are of immunological significance...
  52. ncbi Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells
    S T Smiley
    Department of Cancer Biology, Harvard School of Public Health HSPH, Boston, MA 02115, USA
    Science 275:977-9. 1997
    ..Thus, although dependent on CD1 for their development, IL-4-secreting NK-like T cells are not required for TH2 responses...
  53. ncbi Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove
    Z Zeng
    Department of Molecular Biology and the Skaggs Institute for Chemical Biology at the Scripps Research Institute, La Jolla, CA 92037, USA
    Science 277:339-45. 1997
    ..The crystal structure of mouse CD1d1, corresponding to human CD1d, at 2...
  54. ncbi Critical role of NK1+ T cells in IL-12-induced immune responses in vivo
    T Kawamura
    Department of Immunology, Niigata University School of Medicine, Japan
    J Immunol 160:16-9. 1998
    ..These results indicate that NK1+ T cells play a critical role in IL-12-induced production of IFN-gamma to initiate Th1 immune responses and as IL-12-induced cytotoxic effector cells to initiate antitumor immunity...
  55. pmc The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells
    H Kitamura
    Section of Genetic Engineering, Research Center for Genetic Engineering and Cell Transplantation, Tokai University School of Medicine, Isehara 259 1193, Japan
    J Exp Med 189:1121-8. 1999
    ..Our results also suggest a novel approach for immunotherapy of cancer...
  56. pmc Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis
    S M Behar
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 189:1973-80. 1999
    ..In contrast, CD1D-/- mice were not significantly different in their susceptibility to infection than control mice...
  57. pmc Selection and expansion of CD8alpha/alpha(1) T cell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules
    S H Park
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Exp Med 190:885-90. 1999
    ....
  58. ncbi Comparative contribution of CD1 on the development of CD4+ and CD8+ T cell compartments
    B Wang
    Gwen Knapp Center for Lupus, Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 164:739-45. 2000
    ..Our data suggest that, unlike other MHC class I molecules, CD1 does not contribute in a major way to the development of CD8+ T cells...
  59. ncbi Cutting edge: the Ets1 transcription factor is required for the development of NK T cells in mice
    T L Walunas
    Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA
    J Immunol 164:2857-60. 2000
    ..We conclude that Ets1 defines a novel transcriptional regulatory pathway that is required for the development of both the NK and NK T cell lineages...
  60. ncbi Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice
    L J Saubermann
    Division of Gastroenterology and the Harvard Digestive Diseases Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Gastroenterology 119:119-28. 2000
    b>CD1d is a major histocompatibility complex class I-like molecule that presents glycolipid antigens to a subset of natural killer (NK)1.1(+) T cells...
  61. ncbi Cutting edge: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi
    H Kumar
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA
    J Immunol 165:4797-801. 2000
    ..In this study, we examined the role of CD1d in resistance to infection with the Lyme disease spirochete, Borrelia burgdorferi (Bb), an organism with ..
  62. pmc Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse
    F D Shi
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:6777-82. 2001
    ..Here we demonstrate that both CD1d-null NOD and CD1d-null NOD/BDC2...
  63. pmc CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes
    B Wang
    Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    J Exp Med 194:313-20. 2001
    NK T cells are a unique subset of T cells that recognize lipid antigens presented by CD1d. After activation, NK T cells promptly produce large amounts of cytokines, which may modulate the upcoming immune responses...
  64. ncbi NKT cells derive from double-positive thymocytes that are positively selected by CD1d
    L Gapin
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Nat Immunol 2:971-8. 2001
    b>CD1d-reactive NKT cells are a separate T cell sublineage...
  65. pmc Dendritic cell maturation overrules H-2D-mediated natural killer T (NKT) cell inhibition: critical role for B7 in CD1d-dependent NKT cell interferon gamma production
    Y Ikarashi
    Unite d immunologie, Departement de Biologie Clinique, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Exp Med 194:1179-86. 2001
    Given the broad expression of H-2 class Ib molecules on hematopoietic cells, antigen presentation pathways among CD1d expressing cells might tightly regulate CD1d-restricted natural killer T (NKT) cells...
  66. ncbi CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance
    Koh Hei Sonoda
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Eur J Immunol 32:848-57. 2002
    b>CD1d-reactive NKT cells are required for the development of antigen-specific T regulatory (Tr) cells responsible for mediating systemic tolerance induced through an immune privileged site such as the eye...
  67. ncbi Regulation of CD1d expression by murine tumor cells: escape from immunosurveillance or alternate target molecules?
    Tim Fiedler
    Department of Medical Microbiology, Johannes Gutenberg University, Mainz, Germany
    Int J Cancer 98:389-97. 2002
    ..e., the group II CD1 antigens, which are split into CD1D1 and CD1d2...
  68. ncbi Homeostasis of V alpha 14i NKT cells
    Jennifer L Matsuda
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Nat Immunol 3:966-74. 2002
    b>CD1d-reactive natural killer T (NKT) cells with an invariant V alpha 14 rearrangement (V alpha 14i) are a distinct subset of T lymphocytes that likely have important immune-regulatory functions...
  69. ncbi Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant V alpha 14-J alpha 281 TCR
    Branka Grubor-Bauk
    Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    J Immunol 170:1430-4. 2003
    ..In J alpha 281 GKO mice there was also impairment of virus clearance, resembling that seen in CD1 GKO mice. These results imply roles for the V alpha 14-J alpha 281 subset of NKT cells and for CD1d in control of HSV infection.
  70. pmc Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency
    Aleksandar K Stanic
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 100:1849-54. 2003
    ..In striking contrast, the same hybridomas fail to react to CD1d1 expressed by a beta-D-GlcCer-deficient cell line...
  71. ncbi CD1d-mediated stimulation of natural killer T cells selectively activates hepatic natural killer cells to eliminate experimentally disseminated hepatoma cells in murine liver
    Takuya Miyagi
    Department of Molecular Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Cancer 106:81-9. 2003
    ..including natural killer (NK) cells and natural killer T (NKT) cells, the latter of which become activated in a CD1d-restricted manner by alpha-galactosylceramide (alpha-GalCer)...
  72. pmc The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells
    Dirk Elewaut
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    J Exp Med 198:1133-46. 2003
    ..AP-3 interacts with mouse CD1d, and cells from mice deficient for AP-3 have increased cell surface levels of CD1d and decreased expression in late ..
  73. pmc Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved
    Jang June Park
    Departments of Microbiology and Immunology, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 101:1022-6. 2004
    ..of lipid antigen presentation by CD1 molecules, we have characterized the natural ligands associated with mouse CD1d1 as well as human CD1b and CD1d molecules...
  74. pmc CD1d-dependent activation of NKT cells aggravates atherosclerosis
    Emmanuel Tupin
    Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden
    J Exp Med 199:417-22. 2004
    ..Natural killer T (NKT) cells can recognize lipid antigens presented by CD1 molecules. We have explored the role of CD1d-restricted NKT cells in atherosclerosis by using apolipoprotein E-deficient (apoE-/-) mice, a hypercholesterolemic ..
  75. ncbi NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes
    Aleksandar K Stanic
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 172:2265-73. 2004
    ..Thus, antiapoptotic signals relayed by NF-kappaB critically control cell fate specification and molecular differentiation of iNKT cells and, hence, reveal a novel role for such signals within the immune system...
  76. pmc Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide
    Alex Jahng
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Exp Med 199:947-57. 2004
    ..It is not yet known whether CD1d-restricted T cells reactive to myelin-derived lipids are present in the CNS and might be targeted to influence the ..
  77. ncbi CD1d function is regulated by microsomal triglyceride transfer protein
    Suzana Brozovic
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 10:535-9. 2004
    b>CD1d is a major histocompatibility complex (MHC) class I-related molecule that functions in glycolipid antigen presentation to distinct subsets of T cells that express natural killer receptors and an invariant T-cell receptor-alpha chain (..
  78. ncbi Natural killer T cells accelerate atherogenesis in mice
    Yukihito Nakai
    Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Blood 104:2051-9. 2004
    We have investigated the potential role of CD1d-restricted natural killer T (NKT) cells in the development of atherosclerosis in mice...
  79. ncbi The role of CD1d in the immune response against Listeria infection
    Victor Arrunategui-Correa
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA
    Cell Immunol 227:109-20. 2004
    To address the role of CD1d in mucosal immune regulation in bacterial infection, we infected CD1d KO mice with Listeria monocytogenes (Lm)...
  80. pmc Resistance of CD1d-/- mice to ultraviolet-induced skin cancer is associated with increased apoptosis
    Yasuhiro Matsumura
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Am J Pathol 165:879-87. 2004
    ..Recently, we demonstrated that CD1d knockout mice were resistant to UV-induced immunosuppression, prompting us to further address the role of CD1d in ..
  81. ncbi Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 173:3693-706. 2004
    ..unique subset of immunoregulatory T cells that recognize glycolipid Ags presented by the MHC class I-like molecule CD1d. Because of their immunoregulatory properties, NKT cells are attractive targets for the development of ..
  82. ncbi Lysosomal glycosphingolipid recognition by NKT cells
    Dapeng Zhou
    University of Chicago, Department of Pathology, Chicago, IL 60637, USA
    Science 306:1786-9. 2004
    ..Although the TCR of NKT cells is characteristically autoreactive to CD1d, a lipid-presenting molecule, endogenous ligands for these cells have not been identified...
  83. ncbi The mouse CD1d cytoplasmic tail mediates CD1d trafficking and antigen presentation by adaptor protein 3-dependent and -independent mechanisms
    Anna P Lawton
    Division of Developmental Immunology, Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:3179-86. 2005
    The short cytoplasmic tail of mouse CD1d (mCD1d) is required for its endosomal localization, for the presentation of some glycolipid Ags, and for the development of Valpha14i NKT cells...
  84. pmc Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny
    Jelena S Bezbradica
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:5114-9. 2005
    ....
  85. ncbi Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation
    Barbara Giabbai
    Biocrystallography Unit and Mass Spectrometry Unit, DIBIT San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Immunol 175:977-84. 2005
    ..immunoregulatory lymphocytes whose activation is triggered by the recognition of lipid Ags in the context of the CD1d molecules by the TCR. In this study we present the crystal structure to 2...
  86. pmc Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor
    Dirk M Zajonc
    Department of Molecular Biology and The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 6:810-8. 2005
    ..specificity for self glycosphingolipids and microbial cell wall alpha-glycuronosylceramide antigens presented by CD1d molecules...
  87. ncbi The influence of CD1d in postselection NKT cell maturation and homeostasis
    Finlay W McNab
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Immunol 175:3762-8. 2005
    After being positively selected on CD1d-expressing thymocytes, NKT cells undergo a series of developmental changes that can take place inside or outside the thymus...
  88. pmc Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells
    Everett H Meyer
    Division of Immunology, Children s Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:2782-7. 2006
    ..Here we show, in a mouse model of asthma, that activation of pulmonary IL-4/IL-13 producing invariant TCR+ CD1d-restricted natural killer T (NKT) cells is sufficient for the development of airway hyperreactivity (AHR), a ..
  89. pmc Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition
    Datsen G Wei
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 203:1197-207. 2006
    Mouse and human natural killer T (NKT) cells recognize a restricted set of glycosphingolipids presented by CD1d molecules, including self iGb3 and microbial alpha-glycuronosylceramides...
  90. ncbi Cutting edge: impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein
    Yuval Sagiv
    Committee on Immunology, Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 177:26-30. 2006
    ..We found that NPC1-deficient mice lacked Valpha14-Jalpha18 NKT cells, a major population of CD1d-restricted T cells that is conserved in humans...
  91. ncbi GATA-3 regulates the development and function of invariant NKT cells
    Peter J Kim
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:6650-9. 2006
    ..In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent...
  92. pmc Invariant and noninvariant natural killer T cells exert opposite regulatory functions on the immune response during murine schistosomiasis
    Thierry Mallevaey
    Institut National de la Recherche Médicale, U547, Institut Pasteur de Lille, Institut Fédératif de Recherche 142, Universite de Lille 2, Lille F 59019, France
    Infect Immun 75:2171-80. 2007
    b>CD1d-restricted natural killer T (NKT) cells represent a heterogeneous population of innate memory immune cells expressing both NK and T-cell markers distributed into two major subsets, i.e...
  93. ncbi Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity
    Carsten Wiethe
    Department of Dermatology, University Hospital, Erlangen, Germany
    J Immunol 178:4908-16. 2007
    ..the nature of the DC directing T and NKT cell activation and polarization as well as the role of the respective CD1d Ags presented is still unclear...
  94. ncbi Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells
    Elitza Germanov
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 181:81-91. 2008
    ..Preformed transcripts for IL-4, but not IFN-gamma, were reduced in CXCR6-/- liver NKT cells. These data identify critical roles for CXCR6/CXCL16 in NKT cell activation and the regulation of NKT cell homeostasis...
  95. pmc Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans
    Carmela De Santo
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Clin Invest 118:4036-48. 2008
    ..The crosstalk between iNKT and MDSCs was CD1d- and CD40-dependent...
  96. pmc Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells
    Michael I Zimmer
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:1909-14. 2009
    ..Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains...
  97. pmc CD1d activation and blockade: a new antitumor strategy
    Michele W L Teng
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 182:3366-71. 2009
    b>CD1d is expressed on APCs and presents glycolipids to CD1d-restricted NKT cells. For the first time, we demonstrate the ability of anti-CD1d mAbs to inhibit the growth of different CD1d-negative experimental carcinomas in mice...
  98. pmc Cd1d-dependent regulation of bacterial colonization in the intestine of mice
    Edward E S Nieuwenhuis
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 119:1241-50. 2009
    ..gasseri resulted in increased colonization of the small intestine and bacterial translocation in mice lacking Cd1d, an MHC class I-like molecule, compared with WT mice...
  99. pmc Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells
    Maria Blomqvist
    Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Sweden
    Eur J Immunol 39:1726-35. 2009
    The glycosphingolipid sulfatide (SO(3)-3Galbeta1Cer) is a demonstrated ligand for a subset of CD1d-restricted NKT cells, which could regulate experimental autoimmune encephalomyelitis, a murine model for multiple sclerosis, as well as ..
  100. doi Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens
    Kathryn J Farrand
    Malaghan Institute of Medical Research, Wellington, New Zealand
    J Immunol 183:7732-42. 2009
    ..These data suggest a critical role for the langerin(+) compartment of the CD8alpha(+) DC population in cross-priming and IL-12 production...
  101. pmc Invariant NKT cells limit activation of autoreactive CD1d-positive B cells
    Fredrik Wermeling
    Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden
    J Exp Med 207:943-52. 2010
    ..Absence or reduction of iNKT cells as well as absence of CD1d-expression on B cells, needed for direct iNKT-B cell interaction, leads to increased autoreactive B cell activation ..

Research Grants18

  1. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  2. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..In the current model, we believe that TNFa might abrogate T reg cells through induction of CD1d, a non-classical MHC class I protein, and activation of T cells expressing the V?4 T cell receptor...
  3. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
    ..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
  4. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    ..We have also shown that TNFa up-regulates expression of CD1d, a major histocompatibility complex class l-like molecule involved in innate immunity...
  5. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..myocytes or modulation of CD4+ cell phenotype and activation of CD8+alphabeta TCR+ CTL in myocarditis; 2) determine CD1d expression in pathogenic versus non-pathogenic CVB3 infections and the role for lipid or peptide antigens in the ..
  6. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  7. TREATMENT OF TUBERCULOSIS WITH IMMUNOMODULATORS
    Samuel Behar; Fiscal Year: 2003
    ..The main action of a-galactosylceramide is the activation of NKT cells in a CD1d dependent manner...
  8. Antigen-specific CD8+ T cells and protective immunity to tuberculosis
    Samuel M Behar; Fiscal Year: 2010
    ..tuberculosis-specific immune response will also be determined. This proposal will directly assess how CFP10-specific CD8+ T cells contribute to host defense and how their function is modulated by immunity and disease. ..
  9. CDI Molecules & NKT Cells in Host Defense
    RANDY BRUTKIEWICZ; Fiscal Year: 2009
    ..There is a selective loss of NKT cells from the liver and other organs following a virus infection, whereas in CD1d1-deficient mice, a virus infection results in higher levels of cytokine production and faster viral clearance...
  10. TREATMENT OF TUBERCULOSIS WITH IMMUNOMODULATORS
    Samuel Behar; Fiscal Year: 2008
    ..The main action of alphaGalCer is the activation of immunoregulatory CD1d-restricted iNKT cells, which can in turn stimulate both innate and adaptive immunity...
  11. Natural Killer T cells and the immune response to injury
    ELIZABETH KOVACS; Fiscal Year: 2008
    ..and 13, as well as interferon gamma (IFNgamma) subsequent to stimulation of their invariant T cell receptor via the CD1d molecules expressed on conventional antigen presenting cells (APCs)...
  12. ROLE OF THE ALPHAE INTEGRIN IN IMMUNITY TO TUBERCULOSIS
    Samuel Behar; Fiscal Year: 2004
    ..tuberculosis is altered in alphaE deficient mice; and 3) Investigate potential mechanisms by which alphaEbeta7 may affect susceptibility to tuberculosis. ..
  13. Antigen-Presenting Function of CD1 Molecules
    RANDY BRUTKIEWICZ; Fiscal Year: 2004
    ..Murine and human CD1d molecules are recognized by a novel subpopulation of T cells called NKT cells...
  14. IMMUNOLOGICAL BASIS OF SUSCEPTIBILITY TO TUBERCULOSIS
    Samuel Behar; Fiscal Year: 2003
    ..Aim 4. Characterize the immune response to tuberculosis in mouse models that simulate the abnormalities of cell mediated immunity typical of HIV/AIDS patients. ..
  15. FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERS
    MARY CORR; Fiscal Year: 2004
    ..The results of these studies will both contribute to, and will utilize, the resources of the OA biomarker consortium. ..
  16. Tumor cell antigen presentation to CD4 + T lymphocytes
    Suzanne Ostrand Rosenberg; Fiscal Year: 2004
    ..of anti-tumor immunity? Which effector cells, cytokines, and chemokines are induced during therapy? 5) Does tumor burden correlate with tumor-induced immuno-suppression? Does surgical removal of primary tumor reverse mmuno-suppression? ..
  17. Tumor-induced immune suppression.
    Suzanne Ostrand Rosenberg; Fiscal Year: 2010
    ..abstract_text> ..
  18. Cd1d regulation and its effect on NKT cell activation
    Samuel M Behar; Fiscal Year: 2010
    NKT cells are unique T cells that share some properties with NK cells and recognize lipid antigens presented by CD1d. CD1d and NKT cells are evolutionary conserved between humans and mice, and the murine model has provided considerable ..