Cd19

Summary

Gene Symbol: Cd19
Description: CD19 antigen
Alias: AW495831, B-lymphocyte antigen CD19, differentiation antigen CD19
Species: mouse

Top Publications

  1. ncbi CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand
    David Depoil
    Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Immunol 9:63-72. 2008
  2. doi Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction
    Julia Rolf
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    J Immunol 185:4042-52. 2010
  3. pmc Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs
    Ping Xie
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Immunity 27:253-67. 2007
  4. pmc Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes
    Ping Xie
    Department of Microbiology, The University of Iowa, Iowa City, Iowa, USA
    J Leukoc Biol 90:1149-57. 2011
  5. ncbi The PI3K p110delta is required for down-regulation of RAG expression in immature B cells
    Miriam Llorian
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom
    J Immunol 178:1981-5. 2007
  6. ncbi BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
    T Okada
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Immunity 13:817-27. 2000
  7. ncbi Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha
    Amber C Donahue
    Center for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA
    Int Immunol 16:1789-98. 2004
  8. ncbi The calcineurin phosphatase complex modulates immunogenic B cell responses
    Monte M Winslow
    Program in Immunology, Stanford University, Stanford, California 94305, USA
    Immunity 24:141-52. 2006
  9. pmc Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy
    Cecille D Browne
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center and Program of Signal Transduction, Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Immunity 31:749-60. 2009
  10. pmc B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase
    Burles A Johnson
    Immunotherapy and Cancer Centers, Departments of Pathology and Medicine, and Flow Cytometry Core Facility, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 107:10644-8. 2010

Research Grants

Scientific Experts

Detail Information

Publications131 found, 100 shown here

  1. ncbi CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand
    David Depoil
    Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Immunol 9:63-72. 2008
    ..containing immunoglobulin (Ig) M and IgD that recruit the kinase Syk and transiently associate with the coreceptor CD19. Unexpectedly, CD19-deficient B cells were significantly defective in initiation of BCR-dependent signaling, ..
  2. doi Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction
    Julia Rolf
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    J Immunol 185:4042-52. 2010
    ..Our findings support a model in which the magnitude of the GC reaction is controlled by the activity of the PI3K pathway in T(FH) cells...
  3. pmc Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs
    Ping Xie
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Immunity 27:253-67. 2007
    ..These findings indicate that TRAF3 is a critical regulator of peripheral B cell homeostasis and may be implicated in the regulation of peripheral self-tolerance induction...
  4. pmc Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes
    Ping Xie
    Department of Microbiology, The University of Iowa, Iowa City, Iowa, USA
    J Leukoc Biol 90:1149-57. 2011
    ..Additionally, TRAF3(-/-) B cells displayed enhanced TLR-mediated expression of AID and Ig isotype switching. Thus, TRAF3 plays varied and cell type-specific, biological roles in TLR responses...
  5. ncbi The PI3K p110delta is required for down-regulation of RAG expression in immature B cells
    Miriam Llorian
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom
    J Immunol 178:1981-5. 2007
    ..These results demonstrate a role for p110delta in the regulation of RAG gene expression and thereby LC allelic/isotype exclusion...
  6. ncbi BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
    T Okada
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Immunity 13:817-27. 2000
    ..Hence, these data suggest that BCAP bridges BCR-associated kinases to the PI3K pathway by regulating PI3K localization...
  7. ncbi Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha
    Amber C Donahue
    Center for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA
    Int Immunol 16:1789-98. 2004
    ..These findings establish a role for PI3K-p85alpha in differentiation of both follicular and marginal zone B cells, and suggest that these functions are required not solely for the propagation of anti-apoptotic signals...
  8. ncbi The calcineurin phosphatase complex modulates immunogenic B cell responses
    Monte M Winslow
    Program in Immunology, Stanford University, Stanford, California 94305, USA
    Immunity 24:141-52. 2006
    ..By several different criteria, calcineurin is dispensable for B cell tolerance, indicating that this phosphatase complex modulates immunogenic, but not tolerogenic, responses in vivo...
  9. pmc Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy
    Cecille D Browne
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center and Program of Signal Transduction, Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Immunity 31:749-60. 2009
    ..of PI(3,4,5)P(3) in anergic B cells, which was attributable to reduced phosphorylation of the PI3K membrane adaptor CD19, as well as increased expression of the inositol phosphatase PTEN...
  10. pmc B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase
    Burles A Johnson
    Immunotherapy and Cancer Centers, Departments of Pathology and Medicine, and Flow Cytometry Core Facility, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 107:10644-8. 2010
    A discrete population of splenocytes with attributes of dendritic cells (DCs) and coexpressing the B-cell marker CD19 is uniquely competent to express the T-cell regulatory enzyme indoleamine 2,3-dioxygenase (IDO) in mice treated with ..
  11. ncbi Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation
    Yoshiteru Sasaki
    The CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Immunity 24:729-39. 2006
    ..differentiation and proper localization of follicular and marginal zone B cells in the absence of BAFF-R, but not CD19. By replacing BAFF-R signals, constitutive canonical NF-kappaB signaling, a hallmark of various B cell lymphomas, ..
  12. pmc BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs
    Rebecca Mathew
    Committee on Immunology, Department of Pathology, The Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
    Nature 491:618-21. 2012
    ..We propose that this new function is essential to direct the differentiation of several T- and B-cell effector programs, and may also be involved in the oncogenic role of PLZF and BCL6 in leukaemias and lymphomas...
  13. pmc MicroRNAs prevent the generation of autoreactive antibodies
    Laura Belver
    DNA Hypermutation and Cancer Group, Spanish National Cancer Research Center CNIO, Madrid 28029, Spain
    Immunity 33:713-22. 2010
    ..Here, we have examined the role of microRNAs in terminal B cell differentiation by analyzing Cd19-Cre(ki/+) Dicer1(fl/fl) mice...
  14. ncbi Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis
    T R Henion
    Eunice Kennedy Shriver Center, University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
    J Biol Chem 276:30261-9. 2001
    ..These data support a key role for the Lc3 synthase in regulating neolacto-series glycolipid synthesis during embryonic development...
  15. ncbi GATA-3 regulates the development and function of invariant NKT cells
    Peter J Kim
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:6650-9. 2006
    ..In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent...
  16. ncbi Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function
    Amy N Anzelon
    Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, MC 0322, La Jolla, CA 92093, USA
    Nat Immunol 4:287-94. 2003
    ..Inactivation of PTEN rescued germinal center, MZ B and B1 cell formation in CD19-/- mice, arguing that recruitment and activation of PI3K are the dominant roles for CD19 in these B cell ..
  17. doi A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    Koichi Yanaba
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 28:639-50. 2008
    ..In this study, T cell-mediated inflammation was exaggerated in CD19-deficient (Cd19(-/-)) mice and wild-type mice depleted of CD20(+) B cells, whereas inflammation was substantially ..
  18. ncbi Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain
    L J Zhou
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115 6084
    J Immunol 147:1424-32. 1991
    The CD19 molecule is a 95,000 Mr cell-surface protein of human B lymphocytes with two extracellular Ig-like domains and a 240 amino acid cytoplasmic tail...
  19. ncbi Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily
    T F Tedder
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 143:712-7. 1989
    The CD19 (B4) molecule is a m.w. 95,000 cell-surface protein of human B lymphocytes that is expressed before Ig and persists throughout differentiation...
  20. ncbi B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes
    L M Nadler
    J Immunol 131:244-50. 1983
    ..Moreover, the observation that B4 is expressed on almost all early B cell tumors suggests that it may precede B1, CALLA, cytoplasmic mu, and B2 in early B cell ontogeny...
  21. ncbi Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
    P Engel
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 3:39-50. 1995
    b>CD19-deficient mice were generated to examine the role of CD19 in B cell growth regulation in vivo...
  22. ncbi Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
    R C Rickert
    Institute for Genetics, University of Cologne, Germany
    Nature 376:352-5. 1995
    b>CD19 is the hallmark differentiation antigen of the B lineage...
  23. ncbi E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
    G Bain
    Department of Biology, University of California, San Diego, La Jolla 92130
    Cell 79:885-92. 1994
    ..While immunoglobulin germline I mu RAG-1, mb-1, CD19, and lambda 5 transcripts are dramatically reduced in fetal livers of E2A (-/-) mice, B29 and mu degrees ..
  24. pmc B lymphocyte-specific, Cre-mediated mutagenesis in mice
    R C Rickert
    Institute for Genetics, University of Cologne, Weyertal 121, 50931 Cologne, Germany
    Nucleic Acids Res 25:1317-8. 1997
    ..To selectively modify genes in B lymphocytes, we have generated mice (designated CD19-Cre) which express cre under the transcriptional control of the B lineage-restricted CD19 gene...
  25. ncbi CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 158:4662-9. 1997
    ..The effects of altered signaling thresholds in B lymphocytes were examined in CD19-deficient mice and transgenic mice that expressed human CD19 at varying densities...
  26. ncbi TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo
    B B Cazac
    Department of Medicine, The Windeyer Institute of Medical Sciences, University College, London, United Kingdom
    Immunity 13:443-51. 2000
    ..The data reveal differential roles of TbetaR in homeostasis and antigen responsiveness of B cell subpopulations and establish a critical function of the TGF-beta receptor ligand pair in the induction of IgA responses in vivo...
  27. ncbi Analysis of C-MYC function in normal cells via conditional gene-targeted mutation
    I M de Alboran
    Howard Hughes Medical Institute and Children s, Hospital, Center for Blood Research and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Immunity 14:45-55. 2001
    ..We discuss these findings with respect to potential c-Myc functions in proliferation and apoptosis and also discuss potential limitations in the Cre-mediated gene inactivation approach...
  28. ncbi BCR signal through alpha 4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation
    Seiji Inui
    Department of Immunology, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Int Immunol 14:177-87. 2002
    ..role for alpha 4 in B cell activation, the alpha 4 gene was disrupted conditionally in B cells by mating male CD19-Cre mice with female alpha 4-floxed mice...
  29. ncbi Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells
    Kenji Tanigaki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto, 606 8501, Japan
    Nat Immunol 3:443-50. 2002
    ..In contrast, these mice exhibited increased mortality rates after blood-borne bacterial infection, which indicates that MZB cells play pivotal roles in the clearance of these bacteria...
  30. ncbi Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues
    Alexei Tumanov
    Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology and Belozersky Institute of Physico Chemical Biology, Moscow, Russia
    Immunity 17:239-50. 2002
    ..Thus, the organogenic function of B-LTbeta is almost entirely restricted to spleen, where it supports the correct lymphoid architecture that is critical for an effective humoral immune response...
  31. pmc Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination
    Akira Suzuki
    Department of Molecular Cell Biology, Research Institute for Microbial Disease, Osaka University, Osaka 565 0871, Japan
    J Exp Med 197:657-67. 2003
    ..Thus, Pten plays a role in developmental fate determination of B cells and is an indispensable regulator of B cell homeostasis...
  32. ncbi Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
    Toshiki Saito
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Immunity 18:675-85. 2003
    ..Among Notch target genes, the expression level of Deltex1 is prominent in MZB cells and strictly dependent on that of Notch2, suggesting that Deltex1 may play a role in MZB cell differentiation...
  33. ncbi Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting
    Alexei V Tumanov
    Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    Immunol Rev 195:106-16. 2003
    ..in a non-transgenic model, expression of lymphoid tissue chemokines is only minimally dependent on the expression of surface LT complex on B and T lymphocytes...
  34. ncbi Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells
    Miriam Shapiro-Shelef
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Immunity 19:607-20. 2003
    ..B cells lacking Blimp-1 cannot secrete Ig or induce muS mRNA when stimulated ex vivo. Furthermore, although prdm1-/- B cells fail to induce XBP-1, XBP-1 cannot rescue plasmacytic differentiation without Blimp-1...
  35. ncbi Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling
    Marita J Walmsley
    Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Science 302:459-62. 2003
    ..Both GTPases were required to transduce BCR signals leading to proliferation, survival and up-regulation of BAFF-R, a receptor for BAFF, a key survival molecule required for B cell development and maintenance...
  36. ncbi CD19 function in early and late B cell development. II. CD19 facilitates the pro-B/pre-B transition
    Dennis C Otero
    Division of Biology and University of California San Diego Cancer Center, La Jolla, CA 92093, USA
    J Immunol 171:5921-30. 2003
    ..b>CD19 promotes the proliferation and survival of mature B cells, but its role in early B cell development is less well ..
  37. ncbi Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    Joseph T Opferman
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Department of Pathology and Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 426:671-6. 2003
    ..Thus, MCL-1, which selectively inhibits the proapoptotic protein BIM, is essential both early in lymphoid development and later on in the maintenance of mature lymphocytes...
  38. pmc Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses
    Kazuhiko Kuwahara
    Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto 860 8556, Japan
    Proc Natl Acad Sci U S A 101:1010-5. 2004
    ..We conclude that GC-associated nuclear protein is necessary for generation or maintenance of B cells with high-affinity B cell Ag receptors during the maturation in GCs...
  39. ncbi Cellular niches controlling B lymphocyte behavior within bone marrow during development
    Koji Tokoyoda
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Immunity 20:707-18. 2004
    ..Plasma cells again seed CXCL12-expressing cells. We demonstrate the B lymphocyte characteristic location and movement between specific niches within bone marrow during development and suggest that CXCL12 maintains the cells in the niche...
  40. pmc The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity
    Yuchun Nie
    Dept of Microbiology, Columbia University, 701 West 168th St, HHSC 1406, New York, NY 10032, USA
    J Exp Med 200:1145-56. 2004
    ..These findings establish an important role for CXCR4 in regulating homeostasis of B cell compartmentalization and humoral immunity...
  41. ncbi B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae
    Karen M Haas
    Department of Immunology, Box 3010, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 23:7-18. 2005
    ..Transgenic mice overexpressing CD19 (hCD19Tg) generated B-1a cells and natural antibodies that provided protection during infection, while CD19-..
  42. ncbi Role of MHC class II on memory B cells in post-germinal center B cell homeostasis and memory response
    Michiko Shimoda
    Program in Molecular Immunology, Immunotherapy Center, Medical College of Georgia, Augusta, 30912, USA
    J Immunol 176:2122-33. 2006
    ..a conditional allele for the beta-chain of MHC class II (MHC-II) is deleted in the vast majority of all B cells by cd19 promoter-mediated expression of Cre recombinase (IA-B mice)...
  43. ncbi Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells
    Alessio Delogu
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 24:269-81. 2006
    ....
  44. ncbi Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia
    Elisabeth Kamphuis
    Division of Immunology, Paul Ehrlich Institut, Paul Ehrlich Str 51 59, D 63225 Langen, Germany
    Blood 108:3253-61. 2006
    ..In conclusion, our data identify a new effect of direct IFN-alpha/beta stimulation of lymphocytes that profoundly affects lymphocyte redistribution...
  45. pmc Testing gene function early in the B cell lineage in mb1-cre mice
    E Hobeika
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 103:13789-94. 2006
    ..The availability of a mouse line with efficient cre-mediated recombination at an early developmental stage in the B lineage provides an opportunity to study the role of various genes specifically in B cell development and function...
  46. ncbi Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling
    Sidne A Omori
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center and Program of Signal Transduction, Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Immunity 25:545-57. 2006
    ..However, ectopic expression of AID could not fully overcome inhibition of CSR by PI3K, suggesting that PI3K regulates both the expression and function of AID...
  47. ncbi Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    Nicole M Haynes
    Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:5099-108. 2007
    ....
  48. ncbi Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase
    Yuichi Aiba
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Japan
    Blood 111:1497-503. 2008
    ..In this study, we show that deletion of both BCAP and CD19 leads to an almost complete block of BCR-mediated Akt activation and to severe defects in generation of immature ..
  49. pmc Follicular shuttling of marginal zone B cells facilitates antigen transport
    Guy Cinamon
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Nat Immunol 9:54-62. 2008
    ..Marginal zone-follicle shuttling of marginal zone B cells provides an efficient mechanism for systemic antigen capture and delivery to follicular dendritic cells...
  50. ncbi The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells
    Michelle L Janas
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge, United Kingdom
    J Immunol 180:739-46. 2008
    ..These results demonstrate an epistatic relationship between p110delta and PTEN. In addition, they also suggest that additional PI3K catalytic subunits contribute to B cell development and function...
  51. pmc Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
    Michele Weber
    Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, England, UK
    J Exp Med 205:853-68. 2008
    ..Thus, we demonstrate the importance of cooperation between components of the microsignalosome in the amplification of signaling and propagation of B cell spreading, which is critical for appropriate B cell activation...
  52. pmc Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors
    Craig D Jude
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, 725 Remsen, HB7400, Hanover, NH 03755, USA
    Cell Stem Cell 1:324-37. 2007
    ..These studies demonstrate that Mll plays selective and independent roles within the hematopoietic system, maintaining quiescence in HSCs and promoting proliferation in progenitors...
  53. doi Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
    Marco Prinz
    Department of Neuropathology, University of Freiburg, D 79106 Freiburg, Germany
    Immunity 28:675-86. 2008
    ..In contrast, absence of IFNAR on myeloid cells led to severe disease with an enhanced effector phase and increased lethality, indicating a distinct protective function of type I IFNs during autoimmune inflammation of the CNS...
  54. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage...
  55. ncbi Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection
    Luisa Cervantes-Barragan
    Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland
    J Immunol 182:1099-106. 2009
    ....
  56. pmc Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids
    Joao P Pereira
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:403-11. 2009
    ..Our findings identify unique requirements for the retention of B cells in the bone marrow sinusoidal niche and suggest involvement of CB2 in the generation of the B cell repertoire...
  57. pmc The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals
    Koichi Yanaba
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 182:7459-72. 2009
    ..Thereby, both adaptive and innate signals regulate B10 cell development, maturation, CD5 expression, and competence for IL-10 production...
  58. pmc Rho GTPase Cdc42 is essential for B-lymphocyte development and activation
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, OH 45229, USA
    Blood 114:2909-16. 2009
    ..These results reveal multifaceted roles of Cdc42 in B-cell development and activation...
  59. doi Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells
    Helena Cucak
    Immunology Section, BMC D14, Lund University, Lund 22184, Sweden
    Immunity 31:491-501. 2009
    ..Thus, our results identify type I interferon as a natural adjuvant that selectively supports the generation of lymph node resident Tfh cells...
  60. pmc XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development
    Derrick J Todd
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 206:2151-9. 2009
    ..We have developed an XBP1(fl/fl) CD19(+/cre) conditional knockout (XBP1(CD19)) mouse to build upon our current understanding of the function of XBP1 in ..
  61. pmc Cited2 is an essential regulator of adult hematopoietic stem cells
    Kamil R Kranc
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, UK
    Cell Stem Cell 5:659-65. 2009
    ..Taken together, our studies provide genetic evidence that Cited2 selectively maintains adult HSC functions, at least in part, via Ink4a/Arf and Trp53...
  62. pmc Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection
    Yugang Wang
    The University of Chicago, Department of Pathology, Chicago, IL 60637, USA
    Immunity 32:403-13. 2010
    ..These results support a model wherein LT from RORgammat(+) cells orchestrates the innate immune response against mucosal microbial infection...
  63. pmc A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival
    Robert B Henderson
    Division of Immune Cell Biology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Exp Med 207:837-53. 2010
    ..Thus, these studies identify a novel developmental checkpoint that coincides with B cell positive selection...
  64. pmc In vivo regulation of Bcl6 and T follicular helper cell development
    Amanda C Poholek
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 185:313-26. 2010
    ..These data increase our understanding of Bcl6 regulation in T(FH) cells and their differentiation in vivo and identifies a new surface marker that may be functionally relevant in this subset...
  65. pmc Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis
    Takashi Matsushita
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 185:2240-52. 2010
    ..Thus, B10 cells predominantly control disease initiation, whereas Tregs reciprocally inhibit late-phase disease, with overlapping B10 cell and Treg functions shaping the normal course of EAE immunopathogenesis...
  66. pmc Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases
    Ana V Miletic
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center, Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Exp Med 207:2407-20. 2010
    ..As such, assessment of both PTEN and SHIP function are relevant to understanding the etiology of human B cell malignancies that exhibit augmented activation of the PI3K pathway...
  67. pmc IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools
    Jianxun Feng
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 186:1458-66. 2011
    ..the B cell-intrinsic effects of IRF8 deficiency, we generated mice with a conditional allele of Irf8 crossed with CD19-Cre mice (designated IRF8-conditional knockout [CKO])...
  68. pmc Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination
    Beena Patricia Jeevan-Raj
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de Santé et de Recherche Médicale Unité 964 Centre National de Recherche Scientifique Unité Mixte de Recherche 7104, Universite de Strasbourg, 67404 Illkirch, France
    J Exp Med 208:1649-60. 2011
    ..We propose that KAP1 and HP1 tether AID to H3K9me3 residues at the donor switch region, thus providing a mechanism linking AID to epigenetic modifications during CSR...
  69. pmc B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage
    Donna Kirkland
    Department of Immunology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Immunity 36:228-38. 2012
    ..Our results indicate that the lack of intact MyD88 signaling in B cells, coupled with impaired epithelial integrity, enables commensal bacteria to function as highly pathogenic organisms, causing rapid host death...
  70. pmc Aberrant antibody affinity selection in SHIP-deficient B cells
    Wai Hang Leung
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
    Eur J Immunol 43:371-81. 2013
    ..These results illustrate the importance of negative regulation of B-cell responses, as lower thresholds for B-cell activation promote survival of low affinity and deleterious receptors to the detriment of optimal Ab affinity maturation...
  71. pmc Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching
    Anne Bothmer
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 210:115-23. 2013
    ..We conclude that CtIP, Exo1, and RecQ helicases contribute to the metabolism of DNA ends during DSB repair in B lymphocytes and that minimizing resection favors efficient CSR...
  72. doi The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling
    Pieta K Mattila
    Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Immunity 38:461-74. 2013
    ..cytoskeleton disruption triggered signaling requiring not only the B cell receptor (BCR), but also the coreceptor CD19 and tetraspanin CD81, thus providing a mechanism for signal amplification upon surface-bound antigen stimulation...
  73. ncbi Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis
    M Horcher
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 14:779-90. 2001
    ..its late function, we generated a mouse strain carrying a floxed Pax5 allele that was conditionally inactivated by CD19-cre or Mx-cre expression...
  74. ncbi Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors
    Katsuhiko Hayashi
    Division of Molecular Biology, Research Institute for Biological Sciences, Tokyo University of Science, Yamazaki 2669, Noda, 278 0022, Chiba, Japan
    Immunity 18:825-36. 2003
    ..Here we show complete arrest of B cell development at the pre-B cell transition in BASH/CD19 double mutant mice, indicating partial redundancy of the two B cell-specific adaptors...
  75. ncbi Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus
    Elena Vigorito
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, Babraham Institute, Babraham, Cambridge, United Kingdom
    J Immunol 173:3209-14. 2004
    ..We show in this study that B cell activation following high avidity ligation of IgM or coligation of membrane Ig with CD19 elicits similar levels of Ca(2+) flux using different mechanisms...
  76. pmc The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 92:11558-62. 1995
    The phenotypes of CD19-deficient (CD19-/-) mice, and human CD19-transgenic (hCD19TG) mice that overexpress CD19 indicate that CD19 is a response regulator of B-lymphocyte surface receptor signaling...
  77. pmc Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19
    T Fehr
    Institute of Experimental Immunology, Department of Pathology, University Hospital, CH 8091 Zurich, Switzerland
    J Exp Med 188:145-55. 1998
    Coligation of CD19, a molecule expressed during all stages of B cell development except plasmacytes, lowers the threshold for B cell activation with anti-IgM by a factor of 100...
  78. doi Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation
    Eloisa Arana
    Lymphocyte Interaction Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Immunity 28:88-99. 2008
    ..We postulate that this critical role for Rac2 in mediating B cell adhesion and IS formation might apply in all lymphocytes...
  79. pmc ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells
    Hye Suk Yoon
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 189:2393-403. 2012
    ..These results introduce ZBTB32 as a novel regulator of MHC-II gene expression and a potential regulatory partner of Blimp-1 in repressing gene expression...
  80. pmc Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells
    Megan Raetz
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Immunol 14:136-42. 2013
    ..gondii infection identified the T cell-intrinsic TLR pathway as a major regulator of IFN-γ production in CD4(+) T cells responsible for Paneth cell death, dysbiosis and intestinal immunopathology...
  81. pmc Critical role for mouse marginal zone B cells in PF4/heparin antibody production
    Yongwei Zheng
    Blood Research Institute, BloodCenter of Wisconsin, 8727 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Blood 121:3484-92. 2013
    ..Taken together, these data demonstrate that MZ B cells are critical for PF4/heparin-specific antibody production...
  82. ncbi Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes
    L J Zhou
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA
    Immunogenetics 35:102-11. 1992
    b>CD19 is a B lymphocyte cell-surface marker that is expressed early during pre-B-cell differentiation with expression persisting until terminal differentiation into plasma cells...
  83. pmc Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice
    E N Tsitsikov
    Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:10844-9. 1997
    The tetraspanin CD81 is ubiquitously expressed and associated with CD19 on B lymphocytes and with CD4 and CD8 on T lymphocytes...
  84. ncbi Role of antigen receptor affinity in T cell-independent antibody responses in vivo
    Tien An Yang Shih
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Nat Immunol 3:399-406. 2002
    ..However, in competition experiments only the high-affinity B cells responded to antigen. CD19 deficiency increased the affinity threshold of TI-2 responses, whereas Lyn deficiency enhanced clonal expansion but ..
  85. pmc IkappaB kinase signaling is essential for maintenance of mature B cells
    Manolis Pasparakis
    Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
    J Exp Med 196:743-52. 2002
    ..We conclude that maintenance of mature B cells depends on IKK-mediated activation of NF-kappaB...
  86. ncbi The first 3 days of B-cell development in the mouse embryo
    Belen de Andres
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III ISCIII, Majadahonda, Spain
    Blood 100:4074-81. 2002
    ..We describe here a population of c-kit(+)AA4.1(+)CD19(+)Pax5(+) cells present in the aorta-gonad-mesonephros (AGM) area and in the livers of 11-dpc mouse embryos...
  87. ncbi BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses
    Qunrui Ye
    Department of Pathology and Laboratory Medicine, Joseph Stokes Jr Research Institute and Biesecker Pediatric Liver Center, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, PA 19104, USA
    Eur J Immunol 34:2750-9. 2004
    ..Taken together, these data indicate the BAFF/BAFF-R pathway contributes to both T and B cell responses and may be an attractive target for control of acute and chronic allograft rejection...
  88. ncbi Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects
    Sergei I Grivennikov
    Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences and Belozersky Institute of Physico Chemical Biology, 32 Vavilov Str, 119991 Moscow, Russia
    Immunity 22:93-104. 2005
    ..Our data suggest that T-cell-specific TNF ablation may provide a therapeutic advantage over systemic blockade...
  89. ncbi CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction
    Thomas F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Adv Immunol 88:1-50. 2005
    ..complex role for CD22 has recently emerged, including a central role in a novel regulatory loop controlling the CD19/CD21-Src-family protein tyrosine kinase (PTK) amplification pathway that regulates basal signaling thresholds and ..
  90. ncbi Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57
    Natalio Garbi
    Division of Molecular Immunology, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Nat Immunol 7:93-102. 2006
    ..Our results indicate that ERp57 does not influence the redox state of MHC class I molecules but is an essential structural component required for stable assembly of the peptide-loading complex...
  91. ncbi Loss of tolerance of anti-dsDNA B cells in mice overexpressing CD19
    Devon K Taylor
    Department of Biochemistry, The Graduate Program in Biochemistry, The City College of New York, The Graduate Center, CUNY, New York, NY 10016, USA
    Mol Immunol 43:1776-90. 2006
    ..In C57BL/6 mice overexpressing CD19, a molecule, which lowers the threshold for B cell activation, elevated levels of serum autoantibodies have been ..
  92. ncbi Gene expression analysis of myeloid and lymphoid lineage markers during mouse haematopoiesis
    E Sakhinia
    Division of Laboratory and Regenerative Medicine, School of Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK
    Br J Haematol 135:105-16. 2006
    ..To overcome this, the expression profile of lymphoid and myeloid-associated genes (LEF1, EBF, CD19, Sox-4, B29, CD45, C-fms, lysozyme, PU...
  93. pmc Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes
    Mark C Coles
    Division of Molecular Immunology and Immune Cell Biology and Confocal Microscopy and Image Analysis Laboratory, National Institute for Medical Research, Mill Hill, London, United Kingdom
    Proc Natl Acad Sci U S A 103:13457-62. 2006
    ..Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role...
  94. pmc Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G
    Hideki Sanjo
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Mol Cell Biol 27:1236-46. 2007
    ..Notably, this defect was countered by overexpression of the antiapoptotic factor Bcl-2. Together, our results suggest that ERK2 plays a key role in efficient generation of antigen-specific IgG-bearing B cells by promoting their survival...
  95. pmc B-cell development fails in the absence of the Pbx1 proto-oncogene
    Mrinmoy Sanyal
    Department of Pathology, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Blood 109:4191-9. 2007
    ..Conditional inactivation of Pbx1 in pro-B (CD19(+)) cells and thereafter revealed that Pbx1 is not necessary for B-cell development to proceed from the pro-B-cell ..
  96. ncbi Excision of the Frt-flanked neo (R) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination
    Marc Schmidt-Supprian
    The CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Transgenic Res 16:657-60. 2007
    ..In addition our findings suggest that gene expression from the CD19 locus can be increased by the insertion of exogenous enhancer sequences, without compromising B cell specificity.
  97. pmc CD19 expression in B cells is important for suppression of contact hypersensitivity
    Rei Watanabe
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 171:560-70. 2007
    ..However, recent reports have suggested pivotal roles of B cells in CHS. CD19 serves as a positive B-cell response regulator that defines signaling thresholds critical for B-cell responses...
  98. doi p75 Neurotrophin receptor is a marker for precursors of stellate cells and portal fibroblasts in mouse fetal liver
    Kaori Suzuki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Gastroenterology 135:270-281.e3. 2008
    ..HSCs and PFs play pivotal roles in liver regeneration and fibrosis. However, the roles of mesenchymal cells in fetal liver remain poorly understood. In this study, we aimed to characterize mesenchymal cells in mouse fetal liver...
  99. doi Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development
    Kyongrim Kwon
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 28:751-62. 2008
    ....
  100. pmc Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells
    Michael G Kharas
    Department of Molecular Biology and Biochemistry, Center for Immunology, University of California, Irvine, Irvine, California, USA
    J Clin Invest 118:3038-50. 2008
    ..PI3K and mTOR, PI-103, was more effective than rapamycin at suppressing proliferation of mouse pre-B-ALL and human CD19+CD34+)Ph+ ALL leukemia cells treated with the ABL kinase inhibitor imatinib...
  101. doi B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta
    Thomas Henley
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK
    Eur J Immunol 38:3543-8. 2008
    ..Our findings reveal an important role for p110delta in regulating B-cell responses to BAFF...

Research Grants1

  1. Effect of Antibodies/Chemotherapy on Childhood Leukemia
    LARRY HERRERA; Fiscal Year: 2007
    ..We will then develop new treatment regimens for children with multiply relapsed leukemia based on this information. [unreadable] [unreadable]..