Ccr6

Summary

Gene Symbol: Ccr6
Description: chemokine (C-C motif) receptor 6
Alias: CC-CKR-6, CCR-6, Cmkbr6, KY411, C-C chemokine receptor type 6
Species: mouse

Top Publications

  1. ncbi CCR6 expression distinguishes mouse myeloid and lymphoid dendritic cell subsets: demonstration using a CCR6 EGFP knock-in mouse
    Torsten Kucharzik
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Eur J Immunol 32:104-12. 2002
  2. pmc Defensin-related peptide 1 (Defr1) is allelic to Defb8 and chemoattracts immature DC and CD4+ T cells independently of CCR6
    Karen Taylor
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine Western General Hospital, Edinburgh, Scotland, UK
    Eur J Immunol 39:1353-60. 2009
  3. ncbi Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5
    R J Nibbs
    Cancer Research Campaign Laboratories, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    J Biol Chem 272:12495-504. 1997
  4. doi Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis
    Tomotaka Mabuchi
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 187:5026-31. 2011
  5. pmc CCR6 is required for epidermal trafficking of γδ-T cells in an IL-23-induced model of psoriasiform dermatitis
    Tomotaka Mabuchi
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Invest Dermatol 133:164-71. 2013
  6. pmc Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice
    Jinlin Liu
    Shanghai Institute of Immunology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    PLoS ONE 6:e19495. 2011
  7. pmc Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice
    Qun Li
    Department of Hypertension of Shanghai Ruijin Hospital, Shanghai Institute of Hypertension and Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e16483. 2011
  8. pmc CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection
    Rajesh Ravindran
    Center for Infectious Diseases and Microbiology Translational Research, Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 104:12075-80. 2007
  9. ncbi The chemokine receptor CCR6 is an important component of the innate immune response
    Haitao Wen
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Eur J Immunol 37:2487-98. 2007
  10. pmc CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype
    Kazuya Kitamura
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 185:3295-304. 2010

Scientific Experts

  • Andreas Lugering
  • So Hyang Chung
  • Christoph Kleinschnitz
  • Keisuke Nagao
  • Ye Htun Oo
  • Ifor Williams
  • Lander J Robays
  • Timothy J Paradis
  • Stephanie Verschuere
  • Sergio A Lira
  • Rosa Varona
  • Johann Röhrl
  • Gabriel Marquez
  • Joshua M Farber
  • Nicholas W Lukacs
  • Tomotaka Mabuchi
  • Anja Lechner
  • Torsten Kucharzik
  • Florent Ginhoux
  • Hans Willi Mittrücker
  • Hans Joachim Paust
  • Carlos Martinez-A
  • Qun Li
  • Sam T Hwang
  • Lara E Kallal
  • Jan Eric Turner
  • Thomas Hehlgans
  • Frank Tacke
  • De Yang
  • Heinrich Korner
  • Gerard Eberl
  • Natalia Martin-Orozco
  • Valerie R Stolberg
  • Tomohide Yamazaki
  • Donnele Daley
  • Stephen W Chensue
  • Rajesh Ravindran
  • Rafael M Rezende
  • Ruan Zhang
  • Bo Chin Chiu
  • E J Jaehne
  • Matthias Klein
  • Linda Hammerich
  • Shaomin Hu
  • Yoshiko Fukuyama
  • Terry G Coursey
  • Magdalena Huber
  • Amir R Hajrasouliha
  • Kota Moriguchi
  • Sihyug Jang
  • Julia Farache
  • Florian Wiede
  • Tomonori Takekoshi
  • Kristin Seré
  • Thomas Barth
  • Vanesa Cadenas
  • Yong Lu
  • Immo Prinz
  • Fang Ke
  • Masashi Ebisawa
  • Vanja Sisirak
  • Shaun R McColl
  • Anett Peters
  • Wuzhou Wan
  • Honglin Wang
  • Hong Wang
  • Christopher Schliehe
  • Weiwei Zhang
  • Iain Comerford
  • Hideya Kitamura
  • Ulf Panzer
  • Noah J Tubo
  • Oliver M Steinmetz
  • Qibin Leng
  • Laure Dumoutier
  • Joachim Velden
  • Jan Hendrik Riedel
  • Jinlin Liu
  • Rolf A K Stahl
  • Brian L Kelsall
  • Ana Belen Blazquez
  • Daniela N Männel
  • Catherine Botteron
  • Joost J Oppenheim
  • Kazuya Kitamura
  • Kyoung Yul Seo
  • Uwe Ritter
  • James P Di Santo
  • Michael N Hedrick
  • Karen Taylor

Detail Information

Publications93

  1. ncbi CCR6 expression distinguishes mouse myeloid and lymphoid dendritic cell subsets: demonstration using a CCR6 EGFP knock-in mouse
    Torsten Kucharzik
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Eur J Immunol 32:104-12. 2002
    ..To determine how CCR6 influences cell trafficking, a mutant allele of the mouse CCR6 gene was produced that includes an enhanced green ..
  2. pmc Defensin-related peptide 1 (Defr1) is allelic to Defb8 and chemoattracts immature DC and CD4+ T cells independently of CCR6
    Karen Taylor
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine Western General Hospital, Edinburgh, Scotland, UK
    Eur J Immunol 39:1353-60. 2009
    ..Beta-defensins have previously been shown to attract iDC through CC receptor 6 (CCR6) but neither Defr1 or its related peptides nor Defb8, chemoattract cells overexpressing CCR6...
  3. ncbi Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5
    R J Nibbs
    Cancer Research Campaign Laboratories, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    J Biol Chem 272:12495-504. 1997
    ....
  4. doi Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis
    Tomotaka Mabuchi
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 187:5026-31. 2011
    ..dermatitis in mice, we demonstrate that IL-22, IL-17A, and the IL-23R were highly enriched in a population of CCR6(+), TCR γδ-low expressing (GDL) T cells that accumulated in the epidermis after IL-23 injections...
  5. pmc CCR6 is required for epidermal trafficking of γδ-T cells in an IL-23-induced model of psoriasiform dermatitis
    Tomotaka Mabuchi
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Invest Dermatol 133:164-71. 2013
    A subset of CC chemokine receptor-6(+) (CCR6(+)), γδ-low (GDL) T cells that express Th17 cytokines in mouse skin participates in IL-23-induced psoriasiform dermatitis...
  6. pmc Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice
    Jinlin Liu
    Shanghai Institute of Immunology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    PLoS ONE 6:e19495. 2011
    ..FoxP3(+) regulatory T (Treg)-cells dominantly infiltrate CRC. However, the underlying molecular mechanism in which TAMs may contribute to the trafficking of Treg-cells to the tumor mass remains unknown...
  7. pmc Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice
    Qun Li
    Department of Hypertension of Shanghai Ruijin Hospital, Shanghai Institute of Hypertension and Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e16483. 2011
    ..Although increased levels of plasminogen activators have been found in psoriatic lesions, the role of plasmin converted from plasminogen by plasminogen activators in pathogenesis of psoriasis has not been investigated...
  8. pmc CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection
    Rajesh Ravindran
    Center for Infectious Diseases and Microbiology Translational Research, Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 104:12075-80. 2007
    The contribution of CCR6 and phagocyte recruitment to the initiation of T cell responses to a local pathogen is unclear. CD4 T cell activation to an injected soluble antigen occurred rapidly and was completely CCR6-independent...
  9. ncbi The chemokine receptor CCR6 is an important component of the innate immune response
    Haitao Wen
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Eur J Immunol 37:2487-98. 2007
    In our initial studies we found that naïve CCR6-deficient (CCR6(-/-)) C57BL/6 mice possessed significantly lower number of both F4/80(+) macrophages and dendritic cells (DC), but higher number of B cells in the peritoneal cavity, as ..
  10. pmc CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype
    Kazuya Kitamura
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 185:3295-304. 2010
    Expression of CCR6 and its ligand, CCL20, are increased in the colon of humans with inflammatory bowel diseases and mice with experimental colitis; however, their role in disease pathogenesis remains obscure...
  11. pmc Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    Keiji Hirota
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 204:2803-12. 2007
    ..Th17 cells induced in vivo in normal mice via homeostatic proliferation similarly express CCR6, whereas those inducible in vitro by transforming growth factor beta and IL-6 additionally need IL-1 and ..
  12. pmc CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC
    Lara E Kallal
    Department of Molecular and Cellular Pathology, The University of Michigan, Ann Arbor, MI 48109, USA
    Eur J Immunol 40:1042-52. 2010
    ..Chemokine receptor 6 (CCR6) is found on immature DC and effector/memory T cells, and binds a single ligand, CCL20, with high affinity...
  13. pmc Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells
    Johann Röhrl
    Institute of Immunology, University of Regensburg, Regensburg D 93042, Germany
    J Biol Chem 285:7028-34. 2010
    ..innate inflammatory and systemic adaptive immune responses, which are in part mediated by the CC-chemokine receptor CCR6. Here we report the expression of recombinant mBD4 and its human orthologue hBD2 fused to the constant domain of ..
  14. doi CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells
    Jan D Haas
    Hannover Medical School, Institute for Immunology, Hannover, Germany
    Eur J Immunol 39:3488-97. 2009
    ..gammadelta T cells of the adult thymus are segregated into two lineages by the mutually exclusive expression of CCR6 and NK1.1. Only CCR6+ gammadelta T cells produced IL-17A, while NK1...
  15. pmc CCR6 is required for IL-23-induced psoriasis-like inflammation in mice
    Michael N Hedrick
    Inflammation Biology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 119:2317-29. 2009
    ..Th17 cells produce IL-22 and display CCR6, the CCL20 receptor; CCR6+ T cells and CCL20 are abundant in psoriatic skin...
  16. pmc Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis
    Adam Elhofy
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago IL 60611, USA
    J Neuroimmunol 213:91-9. 2009
    ..In the present study, we investigated the role of the CCL20 receptor, CCR6, in chronic EAE...
  17. pmc Tracing functional antigen-specific CCR6 Th17 cells after vaccination
    Johann Pötzl
    Institute of Immunology, University of Regensburg, Regensburg, Germany
    PLoS ONE 3:e2951. 2008
    ..CC-chemokine receptor 6 (CCR6) is a trait of tissue-homing effector T cells and has recently been described as a receptor on T helper type 17 (..
  18. doi CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues
    Ricardo Villares
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Madrid, Spain
    Eur J Immunol 39:1671-81. 2009
    ..We studied CCR6 function in EAE, a CD4(+) T-cell-mediated CNS disease characterized by mononuclear infiltration and demyelination...
  19. doi Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    Djahida Bouskra
    Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS, URA1961
    Nature 456:507-10. 2008
    ..receptor in epithelial cells, and beta-defensin 3- and CCL20-mediated signalling through the chemokine receptor CCR6. Maturation of ILFs into large B-cell clusters requires subsequent detection of bacteria by toll-like receptors...
  20. pmc CCR6 regulates the migration of inflammatory and regulatory T cells
    Tomohide Yamazaki
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 181:8391-401. 2008
    ..In this study, we report that these two T cell subsets both express CCR6. CCR6 expression in Th17 cells is regulated by TGF-beta and requires two nuclear receptors, RORalpha and RORgamma...
  21. pmc The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut
    C Wang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, USA
    Mucosal Immunol 2:173-83. 2009
    ..We report that Th17 cells preferentially migrate to the intestine and associated lymphoid tissues, and CCR6 is the homing receptor important for Th17 cell migration to certain tissue microenvironments of the intestine such ..
  22. doi Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response
    Adrian Liston
    School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia, Australia
    J Immunol 182:3121-30. 2009
    ..The chemokine ligand/receptor pairing CCL20/CCR6 is interesting because these molecules display characteristics of both homeostatic and activation functions...
  23. doi C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
    Andrea Reboldi
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:514-23. 2009
    ..Here we found that mice lacking CCR6, a chemokine receptor characteristic of T(H)-17 cells, developed T(H)-17 responses but were highly resistant to the ..
  24. ncbi Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha
    R Varona
    Departamento de Immunología y Onocología, Centro Nacional de Biotecnologia, Universidad Autonoma de Madrid, Cantoblanco, Spain
    FEBS Lett 440:188-94. 1998
    We have cloned the murine CCR6 receptor and its ligand, the beta-chemokine mMIP-3alpha. Calcium mobilization assays performed with mCCR6 transfectants showed significant responses upon addition of mMIP-3alpha...
  25. ncbi CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue
    D N Cook
    Department of Immunology, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Immunity 12:495-503. 2000
    ..Here, we demonstrate that in mice lacking the chemokine receptor CCR6, dendritic cells expressing CD11c and CD11b are absent from the subepithelial dome of Peyer's patches...
  26. pmc CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches
    Rosa Maria Salazar-Gonzalez
    Department of Medicine, GI Division and Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, McGuire Translational Research Facility, Minneapolis, Minnesota 55455, USA
    Immunity 24:623-32. 2006
    ..This DC subset is characterized by the expression of the chemokine receptor CCR6 and is found only in PPs...
  27. ncbi Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo
    Marie Le Borgne
    INSERM U404 Immunité et Vaccination, IFR128 Biosciences Lyon Gerland, F 69365 Lyon, France
    Immunity 24:191-201. 2006
    ..Gr1+ monocytes, precedes the sequential accumulation of CD11c+ MHC class II+ DCs in dermis and epithelium via a CCR6/CCL20-dependent mechanism...
  28. pmc Langerhans cells arise from monocytes in vivo
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 7:265-73. 2006
    ..These results identify Gr-1(hi) monocytes as the direct precursors for LCs in vivo and establish the importance of the CSF-1 receptor in this process...
  29. pmc CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses
    R Varona
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    J Clin Invest 107:R37-45. 2001
    b>CCR6 expression in dendritic, T, and B cells suggests that this beta-chemokine receptor may regulate the migration and recruitment of antigen-presenting and immunocompetent cells during inflammatory and immunological responses...
  30. pmc Requirement for the chemokine receptor CCR6 in allergic pulmonary inflammation
    N W Lukacs
    Department of Immunology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    J Exp Med 194:551-5. 2001
    ..To determine the biologic relevance of this expression, mice lacking CCR6, the only known receptor for MIP-3alpha, were studied for their response to CA...
  31. ncbi CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells
    Xinyan Zhao
    Department of Epidemiology and Public Health and Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 171:2797-803. 2003
    ..distributed in the subepithelial dome regions of the Peyer's patches, and mice deficient in the receptor for CCL20, CCR6, have been reported to be devoid of the CD11b(+) DCs in the dome regions...
  32. ncbi CCR6 has a non-redundant role in the development of inflammatory bowel disease
    Rosa Varona
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma de Madrid, Madrid, Spain
    Eur J Immunol 33:2937-46. 2003
    ..of intestinal mucosa, as deduced from the defects in intestinal leukocyte homeostasis shown by mice lacking CCR6, the CCL20 receptor. We studied the response of CCR6-deficient mice in two models of inflammatory bowel disease...
  33. ncbi CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset
    Markus Kleinewietfeld
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13125 Berlin, Germany
    Blood 105:2877-86. 2005
    ..In this study we show that the chemokine receptor CCR6 is expressed on a distinct subset of mouse Treg cells...
  34. pmc Impaired lung dendritic cell activation in CCR2 knockout mice
    Bo Chin Chiu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, USA
    Am J Pathol 165:1199-209. 2004
    ..To determine the role of chemokines in DC mobilization, we applied this analysis to CCR1, CCR2, CCR5, and CCR6 chemokine receptor knockout mice...
  35. ncbi Protective immunity and delayed type hypersensitivity reaction are uncoupled in experimental Leishmania major infection of CCR6-negative mice
    Anja Lechner
    Nachwuchsgruppe 1 des Interdisziplinären Zentrums für Klinische Forschung am Nikolaus Fiebiger Zentrum der Universität Erlangen Nürnberg, Erlangen, Germany
    Microbes Infect 9:291-9. 2007
    The chemokine receptor CCR6 is expressed on naïve B cells, dendritic cell and T-cell subpopulations and is involved in cell navigation during organogenesis and recruitment in response to inflammatory stimuli...
  36. pmc Identification and characterization of latency-associated peptide-expressing γδ T cells
    Rafael M Rezende
    Ann Romney Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Commun 6:8726. 2015
    ..Identification of TCRγδ+LAP+ regulatory cells provides an avenue for understanding immune regulation and biologic processes linked to intestinal function and disease. ..
  37. doi The C-C chemokine receptor 6 (CCR6) is crucial for Th2-driven allergic conjunctivitis
    So Hyang Chung
    Department of Ophthalmology and Visual Science, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Catholic Institute of Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea Electronic address
    Clin Immunol 161:110-9. 2015
    ..Although CCL20-CCR6 axis has been reported to play a proinflammatory role in several murine models of autoimmune diseases including ..
  38. pmc Expression of the chemokine decoy receptor D6 mediates dendritic cell function and promotes corneal allograft rejection
    Amir R Hajrasouliha
    Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts
    Mol Vis 19:2517-25. 2013
    ..To identify the role of chemokine receptor 6 (D6) expression by dendritic cells (DCs) and its role in corneal transplant immunity...
  39. doi Effects of chemokine receptor signalling on cognition-like, emotion-like and sociability behaviours of CCR6 and CCR7 knockout mice
    E J Jaehne
    Discipline of Psychiatry, University of Adelaide, Adelaide, Australia
    Behav Brain Res 261:31-9. 2014
    ..We have compared the cognition-like behaviour (learning and spatial memory) of CCR6(-/-) and CCR7(-/-) mice with wild type (WT) C57BL/6 mice, in the Barnes maze, as well as a range of other ..
  40. pmc Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses
    Yoshiko Fukuyama
    Departments of Pediatric Dentistry and Microbiology, The Immunobiology Vaccine Center, The Institute of Oral Health Research, The University of Alabama at Birmingham, Birmingham, AL, USA
    PLoS ONE 8:e60453. 2013
    We assessed the role of CCR5(+)/CCR6(+)/CD11b(+)/CD11c(+) dendritic cells (DCs) for induction of ovalbumin (OVA)-specific antibody (Ab) responses following mucosal immunization...
  41. pmc Respiratory syncytial virus infection modifies and accelerates pulmonary disease via DC activation and migration
    Sihyug Jang
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Leukoc Biol 94:5-15. 2013
    ..With the use of CCR6-/- mice that have a primary defect in the recruitment of mDC subsets, reduced exacerbation of disease was observed ..
  42. pmc Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Blood 121:679-91. 2013
    ..6 Tesla. In contrast, established immunoregulatory characteristics of Tregs had no functional relevance. We define herein a novel and unexpected role of Tregs in a primary nonimmunologic disease state...
  43. pmc γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation
    Donnele Daley
    S Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA Department of Cell Biology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA
    Cell 166:1485-1499.e15. 2016
    ..We describe γδT cells as central regulators of effector T cell activation in cancer via novel cross-talk...
  44. pmc Requirement for CD28 in Effector Regulatory T Cell Differentiation, CCR6 Induction, and Skin Homing
    Ruan Zhang
    Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129
    J Immunol 195:4154-61. 2015
    ..Although these mice have normal numbers of Tregs, these cells have lower levels of CTLA-4, PD-1, and CCR6, and the animals develop systemic autoimmunity characterized by prominent skin inflammation...
  45. pmc Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis
    Matthias Klein
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 9:e93057. 2014
    ..Here we studied the role of CCL20 and its receptor CCR6 in pneumococcal meningitis...
  46. pmc Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease
    Terry G Coursey
    Ocular Surface Center, Dept of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e78508. 2013
    ..Here, we demonstrate that the chemokine receptors, CCR6 and CXCR3, which are expressed on Th17 and Th1 cells, respectively, are required for the pathogenesis of dry eye ..
  47. pmc Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis
    Linda Hammerich
    Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
    Hepatology 59:630-42. 2014
    ..We hypothesized a contribution of chemokine receptor CCR6 and its ligand, CCL20, which may regulate migration of T-helper (Th)17, regulatory, and gamma-delta (γδ) T cells...
  48. doi CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse
    Florian Wiede
    Comparative Genomics Center, James Cook University, Townsville, Queensland, Australia
    Immunol Cell Biol 91:335-9. 2013
    The CC-chemokine receptor 6 (CCR6) is expressed constitutively at an intermediate level on naïve B cells and is upregulated after activation on pregerminal center (GC) B cells...
  49. doi Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2
    Johann Röhrl
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Division of Basic Science, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 184:6688-94. 2010
    ..family members to chemoattract immature dendritic cells and CD45RO+ CD4+ T cells through chemokine receptor CCR6. However, because beta-defensins also chemoattract macrophages and monocytes, which do not express CCR6, efforts ..
  50. doi The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis
    Kota Moriguchi
    Division of Neurology, Department of Internal Medicine 3, National Defense Medical College, Tokorozawa, Japan
    J Neuroimmunol 257:53-8. 2013
    ..We examined the role of CCR6 and CCR4 in experimental autoimmune encephalomyelitis (EAE) by using CCR6(-/-)CCR4(-/-) double knockout (DKO) and ..
  51. pmc Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation
    Julia Farache
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 38:581-95. 2013
    ..Intestinal CD103+ DCs are therefore equipped with unique mechanisms to independently complete the processes of uptake, transportation, and presentation of bacterial antigens...
  52. doi Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis
    Hans Joachim Paust
    III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Kidney Int 82:72-83. 2012
    ..stage, Th1 cell-derived IFN-γ was found to inhibit local chemokine CCL20 expression, acting through its receptor CCR6 on Th17 cells, thereby limiting the renal Th17 immune response...
  53. doi Mouse β-defensin 14 (Defb14) promotes tumor growth by inducing angiogenesis in a CCR6-dependent manner
    Johann Röhrl
    Department of Immunology, University of Regensburg, 93053 Regensburg, Germany
    J Immunol 188:4931-9. 2012
    ..promote local innate inflammatory and systemic adaptive immune responses, mediated in part by the interaction with CCR6. We found that mouse β-defensin 14 (mBD14, Defb14), a newly identified member of the mouse β-defensin superfamily,..
  54. pmc Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin
    Keisuke Nagao
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Nat Immunol 13:744-52. 2012
    ..Gr-1(hi) monocyte-derived precursors of LCs whose epidermal entry was dependent on the chemokine receptors CCR2 and CCR6, whereas the chemokine receptor CCR8 inhibited the recruitment of LCs...
  55. doi CD8- dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivo
    Christopher Schliehe
    Division of Immunology, Department of Biology, Constance University, 78457 Konstanz, Germany
    J Immunol 187:2112-21. 2011
    ..Moreover, immune responses in BATF3 knockout mice lacking CD8(+) DCs were normal. The results presented in this work strongly suggest that in vivo cross-priming of PLGA MS-encapsulated Ag is performed by CD8(-) DCs and MΦs...
  56. pmc CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver
    Ye Htun Oo
    Centre for Liver Research and NIHR Biomedical Research Unit in Liver Disease, University of Birmingham, Birmingham, United Kingdom
    J Hepatol 57:1044-51. 2012
    ..IL-17 secreting CD4 (Th17) and CD8 (Tc17) T cells have been implicated in immune-mediated liver diseases, but the molecular basis for their recruitment and positioning within the liver is unknown...
  57. pmc An early reduction in Treg cells correlates with enhanced local inflammation in cutaneous leishmaniasis in CCR6-deficient mice
    Thomas Barth
    Institute of Immunology, University of Regensburg, Regensburg, Germany
    PLoS ONE 7:e44499. 2012
    ..The chemokine receptor CCR6 is shared by anti-inflammatory regulatory T cells and pro-inflammatory Th17 cells...
  58. pmc Th9 cells promote antitumor immune responses in vivo
    Yong Lu
    Department of Lymphoma and Myeloma, Division of Cancer Medicine, and Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 122:4160-71. 2012
    ..Th9 cells also elicited strong host antitumor CD8+ CTL responses by promoting Ccl20/Ccr6-dependent recruitment of DCs to the tumor tissues...
  59. doi Two distinct types of Langerhans cells populate the skin during steady state and inflammation
    Kristin Seré
    Institute for Biomedical Engineering, Department of Cell Biology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
    Immunity 37:905-16. 2012
    ..Our data demonstrate the presence of two types of LCs that develop through different pathways in inflammation and steady state...
  60. pmc IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis
    Magdalena Huber
    Institute for Medical Microbiology and Hygiene, University of Marburg, Marburg, Germany
    J Clin Invest 123:247-60. 2013
    ..Our results reveal that Tc17 cells contribute to the initiation of CNS autoimmunity in mice and humans by supporting Th17 cell pathogenicity...
  61. pmc Programmed downregulation of CCR6 is important for establishment of epidermal γδT cells by regulating their thymic egress and epidermal location
    Shaomin Hu
    Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 190:3267-75. 2013
    ..We report in this study that the temporally and spatially regulated downregulation of chemokine receptor CCR6 on fetal thymic Vγ3(+) epidermal γδT precursors is involved in their thymic egress and proper localization in ..
  62. ncbi CCR6 regulates the function of alloreactive and regulatory CD4+ T cells during acute graft-versus-host disease
    Rosa Varona
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Darwin 3, Universidad Autonoma de Madrid, Cantoblanco, E 28049, Madrid, Spain
    Leuk Lymphoma 47:1469-76. 2006
    The chemokine receptor CCR6 is expressed by CD4+ T cell effector/memory and regulatory effector/memory (TREM) subsets...
  63. ncbi A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons
    Ivo Lieberam
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, New York, New York 10032, USA
    Neuron 47:667-79. 2005
    ..In its absence, these neurons adopt a dMN-like trajectory, despite preservation of their vMN transcriptional identity. Thus, the status of Cxcr4 signaling helps to determine the initial axonal trajectory of mammalian motor neurons...
  64. ncbi Lymphoid precursors in intestinal cryptopatches express CCR6 and undergo dysregulated development in the absence of CCR6
    Andreas Lugering
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 171:2208-15. 2003
    ..We found that mice deficient in CCR6 exhibited a 2.7-fold increase in the number of alphabeta TCR IEL, but little or no expansion of gammadelta TCR IEL...
  65. ncbi Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice
    Ken R Bracke
    Department of Respiratory Diseases, Ghent University Hospital 7K12IE, De Pintelaan 185, 9000 Ghent, Belgium
    J Immunol 177:4350-9. 2006
    ..The chemokine receptor CCR6 and its ligand MIP-3alpha/CCL20 may be involved in the recruitment of these inflammatory cells...
  66. pmc Absence of CCR6 inhibits CD4+ regulatory T-cell development and M-cell formation inside Peyer's patches
    Andreas Lugering
    Department of Medicine B, University of Munster, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
    Am J Pathol 166:1647-54. 2005
    ..FAE) covering intestinal Peyer's patches (PPs) and is the only known chemokine ligand for the chemokine receptor CCR6. Although CCR6-deficient mice are known to have a perturbed intestinal immune system, little is known about the ..
  67. ncbi CCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responses
    Rosa Varona
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Blood 106:18-26. 2005
    We studied the role of chemokine receptor CCR6 in acute graft-versus-host disease (GvHD), a pathology in which activated, host antigen-specific donor T cells selectively damage tissues such as skin, liver, and gut...
  68. ncbi Attenuation of allergen-induced responses in CCR6-/- mice is dependent upon altered pulmonary T lymphocyte activation
    Steven K Lundy
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 174:2054-60. 2005
    We have established a defect in CCR6-/- mice in response to a cockroach allergen airway challenge characterized by decreased IL-5 production, reduced CD4+ T and B cells as well as decreased eosinophil accumulation...
  69. doi Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement
    Oliver J Harrison
    Respiratory Center of Excellence for Drug Discovery, GlaxoSmithKline, King of Prussia, PA, USA
    Immunol Lett 121:13-21. 2008
    ..Th17 subset demonstrated that the majority of cells with this effector phenotype express the chemokine receptor CCR6. Together these data identify a novel T cell subset associated with pulmonary inflammation as a result of cigarette ..
  70. doi Eye mucosa: an efficient vaccine delivery route for inducing protective immunity
    Kyoung Yul Seo
    Institute for Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
    J Immunol 185:3610-9. 2010
    ..On the basis of these findings, we propose that the eyedrop route is an alternative to mucosal routes for administering vaccines...
  71. pmc Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii
    Ildiko R Dunay
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 29:306-17. 2008
    ..Collectively, these findings illustrate the critical importance of inflammatory monocytes as a first line of defense in controlling intestinal pathogens...
  72. pmc SOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues
    Cheng Rong Yu
    Laboratory of Immunology, Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:1190-8. 2008
    ..b>CCR6 and CXCR3 are also up-regulated on SOCS1-deficient T cells and in situ analysis of the cornea or retina further ..
  73. pmc A functional role for CCR6 on proallergic T cells in the gastrointestinal tract
    Ana Belen Blazquez
    Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 138:275-84.e1-4. 2010
    ..T cells expressing T helper cell (Th) 2 cytokines are critical for experimental food allergy, and we hypothesized that CCL20 is involved in the localization of these cells to the gut...
  74. pmc In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells
    Matthias Lochner
    Laboratory of Lymphoid Tissue Development, Centre National de la Recherche Scientifique URA1961, Institut Pasteur, Paris 75724, France
    J Exp Med 205:1381-93. 2008
    ....
  75. pmc Resistance of chemokine receptor 6-deficient mice to Yersinia enterocolitica infection: evidence of defective M-cell formation in vivo
    Sabine Westphal
    Department of Medicine B, University of Muenster, Albert Schweitzer Strasse 33, D 48149 Muenster, Germany
    Am J Pathol 172:671-80. 2008
    M cells, specialized cells within Peyer's patches (PPs), are reduced in number in chemokine receptor 6 (CCR6)-deficient mice...
  76. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  77. pmc CCR6 identifies lymphoid tissue inducer cells within cryptopatches
    A Lugering
    Department of Medicine B, University of Munster, Munster, Germany
    Clin Exp Immunol 160:440-9. 2010
    The chemokine receptor CCR6 is expressed by dendritic cells, B and T cells predominantly within the organized structures of the gut-associated lymphatic tissue...
  78. pmc CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis
    Jan Eric Turner
    Ill Medizinische Klinik, Hamburg, Germany
    J Am Soc Nephrol 21:974-85. 2010
    ..renal FoxP3+CD4+ regulatory T cells (Tregs) and IL-17-producing CD4+ T (Th17) cells express the chemokine receptor CCR6, whereas IFNgamma-producing Th1 cells are CCR6-...
  79. ncbi CCR6 and CCL20: partners in intestinal immunity and lymphorganogenesis
    Ifor R Williams
    Department of Pathology, Emory University School of Medicine, Whitehead 105D, 615 Michael Street, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1072:52-61. 2006
    The CCR6 chemokine receptor is expressed by most B cells and subsets of T cells and dendritic cells (DCs) found in the gut mucosal immune system...
  80. ncbi Essential role of CCR6 in directing activated T cells to the skin during contact hypersensitivity
    Timothy J Paradis
    Department of Immunology, Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    J Invest Dermatol 128:628-33. 2008
    b>CCR6 is expressed in a number of dermatological inflammatory diseases. Here, we report that mice sensitized with the hapten oxazolone had increased numbers of CCR6+ T cells in the draining lymph nodes...
  81. pmc Cysteine-cysteinyl chemokine receptor 6 mediates invariant natural killer T cell airway recruitment and innate stage resistance during mycobacterial infection
    Valerie R Stolberg
    Department of Pathology, University of Michigan Medical School Ann Arbor, Ann Arbor, Mich, USA
    J Innate Immun 3:99-108. 2011
    This study examined the contribution of cysteine-cysteinyl chemokine receptor 6 (CCR6) to the innate pulmonary antimycobacterial immune response...
  82. ncbi Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation
    Lander J Robays
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    J Immunol 178:5305-11. 2007
    ..Using this approach, we show that CCR2, but not CCR5 or CCR6, directly controls the accumulation of DCs into allergic lungs...
  83. doi IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality
    Laure Dumoutier
    Ludwig Institute for Cancer Research, Brussels Branch, Belgium
    Eur J Immunol 41:1075-85. 2011
    ..gene (Rag2)-deficient mice, and correspond to a discrete innate lymphoid cell population expressing CD25, CCR6 and IL-7R...
  84. pmc CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch
    Masashi Ebisawa
    Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Int Immunol 23:261-9. 2011
    ..We found that a unique B-cell subset characterized by CCR6(hi)CD11c(int) resided in the subepithelial dome (SED) in mouse PP...
  85. doi Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT
    Stephanie Verschuere
    Department of Pathology, Ghent University, Belgium
    Lab Invest 91:1056-67. 2011
    ..Several chemokines are implicated in the pathogenesis, among which is the CCL20-CCR6 pathway...
  86. pmc CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid follicles
    Keely G McDonald
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Pathol 170:1229-40. 2007
    ..Because CC chemokine receptor 6 (CCR6) deficiency affects the generation of mucosal immune responses, we evaluated a potential role for CCR6 in the ..
  87. pmc Chemokine receptor requirements for epidermal T-cell trafficking
    Noah J Tubo
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Pathol 178:2496-503. 2011
    Inflamed skin contains CD4 T-cell subsets that express chemokine receptors CCR4, CCR6, and/or CCR10. Prior attempts to reveal the distinct role(s) of each receptor in T-cell trafficking to skin have not produced a coherent story...
  88. pmc Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β
    Hideya Kitamura
    Department of Pathology, UCSF, San Francisco, California, USA
    J Clin Invest 121:2863-75. 2011
    ..Our data therefore indicate that fibroblasts have a crucial role in regulating both fibrotic and immune responses in the lung...
  89. pmc Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Circ Res 109:374-81. 2011
    The chemokine receptor Ccr6 is a G-protein-coupled receptor expressed on various types of leukocytes identified in mouse atherosclerotic lesions...
  90. pmc CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues
    Vanja Sisirak
    Universite de Lyon, France
    Blood 118:5130-40. 2011
    ..Here, we report that, unlike blood pDCs, a subset of tonsil pDCs express functional CCR6 and CCR10, and their respective ligands CCL20 and CCL27are detected in inflamed epithelia contacting blood ..
  91. pmc CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen
    John J Osterholzer
    Pulmonary and Critical Care Medicine Section, Medical Service, Department of Veterans Affairs Health System, 2215 Fuller Road, Ann Arbor, MI 48105, USA
    J Immunol 175:874-83. 2005
    ..gene-targeted mice lacking either both endothelial selectins (CD62E and CD62P), or the chemokine receptors CCR2 or CCR6. DC, defined as non-autofluorescent, MHC class II(+)CD11c(mod) cells, were detected in blood, enzyme-digested ..
  92. pmc T helper 17 cells promote cytotoxic T cell activation in tumor immunity
    Natalia Martin-Orozco
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 31:787-98. 2009
    ..Moreover, Th17 cells promoted CCL20 chemokine production by tumor tissues, and tumor-bearing CCR6-deficient mice did not respond to Th17 cell therapy...
  93. ncbi Molecular characterization of CCR6: involvement of multiple domains in ligand binding and receptor signaling
    Li Shaung Ai
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC
    J Biomed Sci 11:818-28. 2004
    The CC chemokine receptor 6 (CCR6) is selectively expressed on memory T cells, B cells, and dendritic cells and appears to be involved in the initiation of a memory immune response. The only chemokine ligand for CCR6 is CCL20/MIP-3alpha...