Ccr4

Summary

Gene Symbol: Ccr4
Description: chemokine (C-C motif) receptor 4
Alias: C-C CKR-4, CHEMR1, Cmkbr4, LESTR, Sdf1r, C-C chemokine receptor type 4, chemokine (C-C) receptor 4, fusin, leukocyte-expressed seven-transmembrane-domain receptor
Species: mouse

Top Publications

  1. pmc Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin
    Michiko K Oyoshi
    Division of Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 121:2210-20. 2011
  2. pmc A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations
    Espen S Baekkevold
    Children s Hospital, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:1045-51. 2005
  3. pmc Immunosuppressive effects of CCL17 on pulmonary antifungal responses during pulmonary invasive aspergillosis
    Kristin J Carpenter
    Department of Pathology, University of Michigan Medical School, Room 5216B, Med Sci I, 1301 Catherine Road, Ann Arbor, MI 48109 0602, USA
    Infect Immun 73:7198-207. 2005
  4. ncbi CCR4 is a key modulator of innate immune responses
    Traci L Ness
    Department of Pathology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    J Immunol 177:7531-9. 2006
  5. pmc Cutting Edge: Chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4 T cells under physiological conditions
    James J Campbell
    Department of Dermatology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Immunol 178:3358-62. 2007
  6. pmc CCR4-dependent regulatory T cell function in inflammatory bowel disease
    Qian Yuan
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 204:1327-34. 2007
  7. pmc Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease
    Blythe D Sather
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Exp Med 204:1335-47. 2007
  8. pmc iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity
    Everett H Meyer
    Division of Immunology, Karp Laboratories, Children s Hospital, Boston, MA 02115, USA
    J Immunol 179:4661-71. 2007
  9. pmc Chemokine receptor requirements for epidermal T-cell trafficking
    Noah J Tubo
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Pathol 178:2496-503. 2011
  10. pmc CCR4 participation in Th type 1 (mycobacterial) and Th type 2 (schistosomal) anamnestic pulmonary granulomatous responses
    Christine M Freeman
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Immunol 177:4149-58. 2006

Research Grants

Scientific Experts

  • Tamio Ohno
  • Y Chvatchko
  • Jean Louis Frossard
  • H Scheerens
  • James Campbell
  • Glenda Trujillo
  • Tobias Traeger
  • Jagadeesh Bayry
  • Olivia Osborn
  • Fabienne Mauxion
  • Cory M Hogaboam
  • Steven L Kunkel
  • Irmgard Forster
  • Marc Andre Wurbel
  • Valerie R Stolberg
  • Andrew D Luster
  • Elisha de Valle
  • Alan L Chang
  • Ana Claudia Araujo-Pires
  • Zicheng Hu
  • Nadia A Al-Banna
  • Jennifer E Cowan
  • Gang Li
  • Masayoshi Kamon
  • Andrea J White
  • William E Jenkinson
  • Sonia M Parnell
  • Graham Anderson
  • Eric J Jenkinson
  • Akifumi Honjo
  • Lucas Faustino
  • Kota Moriguchi
  • Kyoko Nakamura
  • Sandra Santulli-Marotto
  • Karola Poppensieker
  • Michiko K Oyoshi
  • Kai Yu
  • Masahiro Miyajima
  • Osamu Yoshie
  • Christian Weber
  • Eileen A Forde
  • Sabina A Islam
  • Noah J Tubo
  • Thomas Quast
  • Susanne Stutte
  • Waldemar Kolanus
  • Rodrigo Guabiraba
  • Sari Lehtimäki
  • Eva Jasmin Freyschmidt
  • Harri Alenius
  • Terhi Savinko
  • Xiaodong Jiang
  • Verena Semmling
  • Nan Zhang
  • Zamaneh Mikhak
  • Toshiharu Onodera
  • Stephen W Chensue
  • Bo Chin Chiu
  • Paul B Savage
  • Makoto Ishii
  • Jun Abe
  • Heidi K Jessup
  • Marlon P Quinones
  • Everett H Meyer
  • Blythe D Sather
  • Mayumi Kusumoto
  • Qian Yuan
  • Traci L Ness
  • Christine M Freeman
  • Espen S Baekkevold
  • Ivo Lieberam
  • Iris Lee
  • Kristin J Carpenter
  • Norbert Hüser
  • Tim O Vilz
  • Jaime Imitola
  • Nicholas W Lukacs
  • Christine A Power
  • Lynn M Corcoran
  • Yu Han
  • Dou Yu
  • Mhairi J Maxwell
  • Deepak Kanojia
  • Jason Miska
  • Evelyn Tsantikos
  • Simon N Willis
  • Atique U Ahmed
  • Axel Kallies
  • Ashish Banerjee
  • Andreas Strasser

Detail Information

Publications72

  1. pmc Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin
    Michiko K Oyoshi
    Division of Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 121:2210-20. 2011
    ..To address this question, we orally immunized WT mice and mice lacking the skin-homing chemokine receptor Ccr4 (Ccr4-/- mice) with OVA and then challenged them epicutaneously with antigen...
  2. pmc A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations
    Espen S Baekkevold
    Children s Hospital, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:1045-51. 2005
    Expression of the chemokine receptor CCR4 is strongly associated with trafficking of specialized cutaneous memory T helper (Th) lymphocytes to the skin...
  3. pmc Immunosuppressive effects of CCL17 on pulmonary antifungal responses during pulmonary invasive aspergillosis
    Kristin J Carpenter
    Department of Pathology, University of Michigan Medical School, Room 5216B, Med Sci I, 1301 Catherine Road, Ann Arbor, MI 48109 0602, USA
    Infect Immun 73:7198-207. 2005
    Aspergillus fumigatus-sensitized CCR4-deficient (CCR4-/-) mice exhibit an accelerated clearance of conidia during fungal asthma...
  4. ncbi CCR4 is a key modulator of innate immune responses
    Traci L Ness
    Department of Pathology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    J Immunol 177:7531-9. 2006
    b>CCR4 is recognized as a key receptor in Th2-associated immune processes, although very little is known about its role in innate immunity...
  5. pmc Cutting Edge: Chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4 T cells under physiological conditions
    James J Campbell
    Department of Dermatology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Immunol 178:3358-62. 2007
    Dual expression of chemokine receptor CCR4 and E-selectin ligand is characteristic of skin-tropic CD4 T cells from blood, lymphoid organs, and the skin itself...
  6. pmc CCR4-dependent regulatory T cell function in inflammatory bowel disease
    Qian Yuan
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 204:1327-34. 2007
    ..We examined the role of the chemokine receptor CCR4 in in vivo trafficking and suppressive function of T reg cells in a mouse adoptive transfer model of IBD...
  7. pmc Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease
    Blythe D Sather
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Exp Med 204:1335-47. 2007
    ..throughout all nonlymphoid tissues tested, and are particularly prevalent in the skin, where they express a unique CCR4(+)CD103(hi) phenotype...
  8. pmc iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity
    Everett H Meyer
    Division of Immunology, Karp Laboratories, Children s Hospital, Boston, MA 02115, USA
    J Immunol 179:4661-71. 2007
    ..Using several models of asthma, we demonstrated that iNKT cells required the chemokine receptor CCR4 for pulmonary localization and for the induction of AHR...
  9. pmc Chemokine receptor requirements for epidermal T-cell trafficking
    Noah J Tubo
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Pathol 178:2496-503. 2011
    Inflamed skin contains CD4 T-cell subsets that express chemokine receptors CCR4, CCR6, and/or CCR10. Prior attempts to reveal the distinct role(s) of each receptor in T-cell trafficking to skin have not produced a coherent story...
  10. pmc CCR4 participation in Th type 1 (mycobacterial) and Th type 2 (schistosomal) anamnestic pulmonary granulomatous responses
    Christine M Freeman
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Immunol 177:4149-58. 2006
    b>CCR4 is purported to be a Th type 2 (Th2) cell-biased receptor but its functional role is unclear...
  11. pmc Detrimental role of CC chemokine receptor 4 in murine polymicrobial sepsis
    Tobias Traeger
    Department of Surgery, Ernst Moritz Arndt Universitat Greifswald, Greifswald, Germany
    Infect Immun 76:5285-93. 2008
    CC chemokine receptor 4 (CCR4) and its two ligands, CCL17 and CCL22, are critically involved in different immune processes...
  12. pmc CC chemokine receptor 4 contributes to innate NK and chronic stage T helper cell recall responses during Mycobacterium bovis infection
    Valerie R Stolberg
    Department of Pathology and Laboratory Medicine, VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA
    Am J Pathol 178:233-44. 2011
    Cysteine-cysteinyl chemokine receptor 4 (CCR4) is expressed by a variety of T-cell subsets and leukocytes...
  13. pmc Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation
    Zamaneh Mikhak
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 123:67-73.e3. 2009
    ..Although CCR4 and CCR8 are preferentially expressed on T(H)2 cells and CCR4, CCR8, and CXCR3 ligands are increased in asthma, the ..
  14. doi Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs
    Verena Semmling
    Institute of Molecular Medicine and Experimental Immunology, Friedrich Wilhelms Universität, Bonn, Germany
    Nat Immunol 11:313-20. 2010
    ..CD8alpha(+) DCs to produce the chemokine CCL17, which attracted naive CTLs expressing the chemokine receptor CCR4. In contrast, DCs licensed by helper T cells recruited CTLs using CCR5 ligands...
  15. pmc Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4
    Xiaodong Jiang
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:7443-8. 2010
    ..To test the role of chemokine receptors in DETC skin homing, we examined skin from CCR4(-/-) and CCR10(-/-) mice, respectively...
  16. pmc Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells
    Susanne Stutte
    Molecular Immunology, Leibniz Institut fuer Umweltmedizinische Forschung, Dusseldorf, Germany
    Proc Natl Acad Sci U S A 107:8736-41. 2010
    ..The beta-chemokine CCL17, a ligand of CCR4, is inducibly expressed in a subset of DCs and is strongly up-regulated in atopic diseases...
  17. doi Absence of CCR4 exacerbates skin inflammation in an oxazolone-induced contact hypersensitivity model
    Sari Lehtimäki
    Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    J Invest Dermatol 130:2743-51. 2010
    Chemokine receptor CCR4 is expressed by Th2 cells and is involved in the recruitment of inflammatory cells into the skin...
  18. pmc Differential requirement for CCR4 in the maintenance but not establishment of the invariant Vγ5(+) dendritic epidermal T-cell pool
    Kyoko Nakamura
    Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e74019. 2013
    ..However, this process occurs independently of Aire's influences on intrathymic chemokines, and in the absence of CCR4 and CCR7 expression by DETC progenitors...
  19. pmc A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock
    Y Chvatchko
    Serono Pharmaceutical Research Institute, 1228 Plan les Ouates Geneva, Switzerland
    J Exp Med 191:1755-64. 2000
    ..Recent studies have shown that CCR4 is the major chemokine receptor expressed by T helper type 2 (Th2) polarized cells...
  20. ncbi Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/- mice and Rag-2-/- mice reconstituted with CD4+CD45RBhigh T cells
    H Scheerens
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304, USA
    Eur J Immunol 31:1465-74. 2001
    ..MIG, RANTES, lymphotactin, MIP-3alpha, TCA-3, TARC, MIP-3beta, LIX, MCP-1 and MIP-1beta and the receptors CCR4, CCR6 and CCR2 were significantly increased in chronically inflamed colons of IL-10-/- mice when compared with ..
  21. pmc Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor
    Iris Lee
    Department of Pathology and Laboratory Medicine, Joseph Stokes Jr Research Institute and Biesecker Pediatric Liver Center, The Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 201:1037-44. 2005
    ..Analysis of multiple chemokine pathways showed that tolerance was accompanied by intragraft up-regulation of CCR4 and one of its ligands, macrophage-derived chemokine (CCL22), and that tolerance induction could not be achieved in ..
  22. ncbi Airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4-/- mice
    Jane M Schuh
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    FASEB J 16:1313-5. 2002
    The role of CC chemokine receptor 4 (CCR4) during the development and maintenance of Th2-type allergic airway disease is controversial...
  23. ncbi Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4
    A Hoogewerf
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Biochem Biophys Res Commun 218:337-43. 1996
    ..This first report of direct binding of chemokines to CC CKR-4 demonstrates that the highly homologous human and murine receptors have similar binding characteristics and tissue distribution...
  24. doi Targeted reduction of CCR4⁺ cells is sufficient to suppress allergic airway inflammation
    Akifumi Honjo
    Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan Electronic address
    Respir Investig 51:241-9. 2013
    Bronchial asthma is characterized by allergic airway inflammation involving C-C chemokine receptor type 4 (CCR4)-positive Th2 cells. As such, we hypothesize that the disease can be alleviated by targeted-elimination of CCR4⁺ cells...
  25. doi CCR4 and CXCR3 play different roles in the migration of T cells to inflammation in skin, arthritic joints, and lymph nodes
    Nadia A Al-Banna
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada
    Eur J Immunol 44:1633-43. 2014
    b>CCR4 and CXCR3 are expressed on several T-cell subsets in inflamed tissues, yet their role in tissue-specific recruitment is unclear...
  26. doi The chemokine-like factor 1 induces asthmatic pathological change by activating nuclear factor-κB signaling pathway
    Gang Li
    Department of Pharmacology, College of Pharmacy, The Inner Mongolian Medical University, Jinshan Development Zone, Hohhot, Inner Mongolian 010110, China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, 1 Xiannongtan Street, Xicheng District, Beijing 100050, China Electronic address
    Int Immunopharmacol 20:81-8. 2014
    ..The HEK293-CCR4 cell line, which expressed CCR4 stably, was established and screened...
  27. pmc Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus
    Jennifer E Cowan
    Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Immunol 193:1204-12. 2014
    ..this study, we show that combining a panel of thymocyte maturation markers with cell surface analysis of CCR7 and CCR4 identifies distinct stages in the development of multiple αβT cell lineages in the thymus...
  28. pmc Engagement of two distinct binding domains on CCL17 is required for signaling through CCR4 and establishment of localized inflammatory conditions in the lung
    Sandra Santulli-Marotto
    Janssen Research and Development, Spring House, Pennsylvania, United States of America Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e81465. 2013
    CCL17 (TARC) function can be completely abolished by mAbs that block either one of two distinct sites required for CCR4 signaling...
  29. pmc Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells
    Masayoshi Kamon
    1 Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, Yamane Hidaka, Saitama, Japan
    Stem Cells Dev 23:2170-9. 2014
    ..This screening led to identification of Cnot2, one of the core components of the Ccr4-Not complex...
  30. pmc IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis
    Ana Claudia Araujo-Pires
    Department of Biological Sciences, School of Dentistry of Bauru, São Paulo University FOB USP, Bauru, SP, Brazil
    J Bone Miner Res 30:412-22. 2015
    ..Tregs extracted from the lesions preferentially express CCR4 and CCR8, whereas Th2 cells express CCR3, CCR4, and CCR8...
  31. pmc CCR4 promotes medullary entry and thymocyte-dendritic cell interactions required for central tolerance
    Zicheng Hu
    Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712
    J Exp Med 212:1947-65. 2015
    ..Mechanisms promoting thymocyte medullary entry and interactions with APCs are incompletely understood. CCR4 is poised to contribute to central tolerance due to its expression by post-positive selection thymocytes, and ..
  32. pmc NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells
    Elisha de Valle
    Burnet Institute, Melbourne, VIC 3004, Australia Immunology, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia
    J Exp Med 213:621-41. 2016
    ..Collectively, our findings identify a previously unrecognized role for NFκB1 in preventing multiorgan autoimmunity through its negative regulation of Il-6 gene expression in Fo B cells...
  33. pmc CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells
    Alan L Chang
    Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois Committee on Cancer Biology, The University of Chicago, Chicago, Illinois
    Cancer Res 76:5671-5682. 2016
    ..and microglia within the glioma microenvironment produce CCL2, a chemokine that is critical for recruiting both CCR4+ Treg and CCR2+Ly-6C+ monocytic MDSCs in this disease setting...
  34. doi The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis
    Kota Moriguchi
    Division of Neurology, Department of Internal Medicine 3, National Defense Medical College, Tokorozawa, Japan
    J Neuroimmunol 257:53-8. 2013
    ..We examined the role of CCR6 and CCR4 in experimental autoimmune encephalomyelitis (EAE) by using CCR6(-/-)CCR4(-/-) double knockout (DKO) and single ..
  35. doi CCR4 dependent migration of Foxp3+ Treg cells to skin grafts and draining lymph nodes is implicated in enhanced graft survival in CD200tg recipients
    Kai Yu
    Transplant Research Division, University Health Network, Toronto, ON, Canada
    Immunol Lett 141:116-22. 2011
    ..analysis we showed this enhanced graft survival is associated with increased expression of Foxp3, GITR, CTLA-4 and CCR4 mRNA, all genes related to T(reg) cell induction/function, and of Gata3, IL-4, IL-5, IL-13, and somewhat ..
  36. pmc CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells
    Karola Poppensieker
    Institute of Molecular Psychiatry, University of Bonn, 53127 Bonn, Germany
    Proc Natl Acad Sci U S A 109:3897-902. 2012
    ..This study demonstrates that expression of CC chemokine receptor 4 (CCR4) by DCs is required for EAE induction...
  37. doi Regulatory T cells migrate to airways via CCR4 and attenuate the severity of airway allergic inflammation
    Lucas Faustino
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP 05508 900, Brazil
    J Immunol 190:2614-21. 2013
    ..that regulatory T (Treg) cells that accumulate in the airways of allergic mice upregulate CC-chemokine receptor 4 (CCR4) expression. These Treg cells suppressed in vitro Th2 cell proliferation but not type 2 cytokine production...
  38. doi Role of CCL-2, CCR-2 and CCR-4 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injury
    Jean Louis Frossard
    Service of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland
    J Clin Pathol 64:387-93. 2011
    ..To address the role of CCL-2, CCR-2 and CCR-4 that attracts leucocytes cells in inflamed tissues, pancreatitis was induced by administering supramaximal doses of cerulein in mice that do not express CCL-2, CCR-2 or CCR-4...
  39. pmc Early acceptance of renal allografts in mice is dependent on foxp3(+) cells
    Masahiro Miyajima
    Transplantation Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Pathol 178:1635-45. 2011
    ..containing numerous CD3(+)Foxp3(+) cells, CD4(+) cells, dedritic cells, and B cells, which was independent of CCR4. The lymphoid sheaths disintegrate after Foxp3 depletion, accompanied by widespread CD8 interstitial mononuclear ..
  40. pmc CCR4 contributes to the pathogenesis of experimental autoimmune encephalomyelitis by regulating inflammatory macrophage function
    Eileen A Forde
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States
    J Neuroimmunol 236:17-26. 2011
    ..Expression of CCR4 and its ligand CCL22 has been observed in ongoing disease...
  41. pmc CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice
    Christian Weber
    Institute for Cardiovascular Prevention, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Clin Invest 121:2898-910. 2011
    ..Our data identify DC-derived CCL17 as a central regulator of Treg homeostasis, implicate DCs and their effector functions in atherogenesis, and suggest that CCL17 might be a target for vascular therapy...
  42. pmc Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells
    Sabina A Islam
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 12:167-77. 2011
    ..Ccr8- and Ccl8-deficient mice had markedly less eosinophilic inflammation than wild-type or Ccr4-deficient mice in a model of chronic atopic dermatitis...
  43. pmc Role of the chemokine receptors CCR1, CCR2 and CCR4 in the pathogenesis of experimental dengue infection in mice
    Rodrigo Guabiraba
    Immunopharmacology, Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS ONE 5:e15680. 2010
    ..We evaluated the role of CC chemokine receptors CCR1, CCR2 and CCR4 in an experimental model of DENV-2 infection in mice...
  44. ncbi Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response
    Heidi K Jessup
    Inflammation Research, Amgen, Seattle, WA 98119, USA
    J Immunol 181:4311-9. 2008
    ..TSLP-induced responses were significantly, but not completely reduced in IL-4- and IL-13-deficient mice. These results shed light on the pathways and cell types involved in TSLP-induced inflammation...
  45. pmc Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue
    Olivia Osborn
    The Harold L Dorris Neurological Research Institute, Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cytokine 53:311-9. 2011
    CC Chemokine ligand 22 (Ccl22) is a selective, high affinity ligand at the CC chemokine receptor 4 (Ccr4)...
  46. ncbi CCR4-deficient mice show prolonged graft survival in a chronic cardiac transplant rejection model
    Norbert Hüser
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Eur J Immunol 35:128-38. 2005
    ..This study investigates the role of chemokine receptor 4 (CCR4) in acute and chronic cardiac allograft rejection in mice...
  47. ncbi Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor
    M Heesen
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 157:5455-60. 1996
    ..Recently, a human protein termed "fusin" with characteristics of a seven-transmembrane-spanning receptor was found to be a co-factor required for the ..
  48. pmc Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin
    T Nagasawa
    Department of Immunology, Osaka Medical Center for Maternal and Child Health, Japan
    Proc Natl Acad Sci U S A 93:14726-9. 1996
    ..The deduced amino acid sequence has 90% identity with that of a HUMSTSR/fusin, a human immunodeficiency virus 1 (HIV-1) entry coreceptor...
  49. ncbi Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms
    M Heesen
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 158:3561-4. 1997
    Inspection of the intron splice junction of the mouse chemokine receptor fusin/CXC chemokine receptor R-4 (CXCR-4) revealed a potential in-frame alternative splice site in the region encoding the N-terminal ectodomain of the receptor...
  50. ncbi Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5
    R J Nibbs
    Cancer Research Campaign Laboratories, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    J Biol Chem 272:12495-504. 1997
    ....
  51. ncbi Molecular cloning and characterization of a cDNA, CHEMR1, encoding a chemokine receptor with a homology to the human C-C chemokine receptor, CCR-4
    B S Youn
    Department of Microbiology and Immunology, and Walther Oncology Center, Indiana University School of Medicine, Indianapolis 46202 5120, USA
    Blood 89:4448-60. 1997
    ..These are known to bind to seven-transmembrane-domain containing receptors. A cDNA clone, CHEMR1, resembling the typical G protein-coupled receptor, was isolated from a mouse cytotoxic T-lymphocyte (CTL) library...
  52. pmc Murine CXCR-4 is a functional coreceptor for T-cell-tropic and dual-tropic strains of human immunodeficiency virus type 1
    P D Bieniasz
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 71:7097-100. 1997
    ..Overall, these data suggest that the reported lack of susceptibility of hCD4+ murine cells to HIV-1 infection in vitro is, at least in part, due to a lack of mCXCR-4 expression rather than a lack of coreceptor function...
  53. ncbi Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4
    K E McGrath
    Department of Pediatrics and Cancer Center, University of Rochester Medical Center, Rochester, New York, 14642, USA
    Dev Biol 213:442-56. 1999
    ..5 and E8.5). Other chemokine receptor messages (CCR1, CCR4, CCR5, CCR2, and CXCR2) were found in E12...
  54. ncbi The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody
    Louise A Jopling
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AZ, United Kingdom
    J Biol Chem 277:6864-73. 2002
    Th2 lymphocytes play a central role in the control and maintenance of allergic inflammation. The chemokine receptor CCR4 is preferentially expressed on the surface of Th2 lymphocytes polarised in vitro...
  55. ncbi Chromosomal mapping of the host resistance locus to rodent malaria (Plasmodium yoelii) infection in mice
    T Ohno
    Institute for Laboratory Animal Research, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Immunogenetics 53:736-40. 2001
    ..Elucidation of the function of this gene will provide valuable insights into the mechanism of host defense against malaria parasite infection...
  56. pmc CCR4-bearing T cells participate in autoimmune diabetes
    Soon H Kim
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 110:1675-86. 2002
    ..In the present study we demonstrate that CCR4 expression marks a pathogenic population of autoimmune T cells...
  57. ncbi Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo
    Tilo Biedermann
    Novartis Research Institute, Vienna, Austria
    Eur J Immunol 32:3171-80. 2002
    ..skin lesions of AD patients, selectively migrate to human skin grafts transplanted onto SCID mice in response to CCR4 but not CCR3, CCR8 or CXCR3 ligands...
  58. pmc Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses
    Eva Jasmin Freyschmidt
    Division of Immunology, Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:1295-302. 2010
    ..To focus on the consequences of Treg deficiency confined to the skin, we generated mixed CCR4(KO) FoxP3(KO) bone marrow (CCR4/FoxP3) chimeras in which skin, but not other tissues or central lymphoid organs, ..
  59. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
    ..CXCR4 expression within germinal zones suggests that NSC homing after injury and migration during development may invoke similar mechanisms...
  60. ncbi A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons
    Ivo Lieberam
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, New York, New York 10032, USA
    Neuron 47:667-79. 2005
    ..In its absence, these neurons adopt a dMN-like trajectory, despite preservation of their vMN transcriptional identity. Thus, the status of Cxcr4 signaling helps to determine the initial axonal trajectory of mammalian motor neurons...
  61. ncbi The SDF-1/CXCR4 pathway and the development of the cerebellar system
    Tim O Vilz
    Anatomisches Institut, Anatomie und Zellbiologie, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Eur J Neurosci 22:1831-9. 2005
    ..Moreover, they fail to express plexin D1, suggesting that SDF-1/CXCR4 signalling may also impinge on axon guidance critical to the orderly formation of granule cell mossy fibre afferents...
  62. pmc Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt
    Marlon P Quinones
    South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, TX, USA
    Mol Cell Neurosci 37:96-109. 2008
    ..On the other hand, receptors like CCR3 and CCR4 were not elevated...
  63. ncbi Expression of chemokine receptor CCR4 and its ligands (CCL17 and CCL22) in murine contact hypersensitivity
    Mayumi Kusumoto
    Department of Environmental Medicine, Kagoshima University School of Medicine, and Department of Medicine, Kagoshima Seikyo Hospital, Japan
    J Interferon Cytokine Res 27:901-10. 2007
    Chemokine receptor CCR4 and its ligands (CCL17 and CCL22) are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases...
  64. pmc A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis
    Glenda Trujillo
    Immunology Program, Department of Pathology, University of Michigan, 4071 BSRB, 109 Zina Pitcher Pl, Ann Arbor, MI 48109 2200, USA
    Am J Pathol 172:1209-21. 2008
    ..The objective of this study was to examine the role of CC chemokine receptor 4 (CCR4) in macrophage polarization during pulmonary oxidative injury in wild-type [WT (CCR4(+/+))] and CCR4-deficient (..
  65. pmc In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination
    Jagadeesh Bayry
    The Edward Jenner Institute for Vaccine Research, University of Oxford, Compton, United Kingdom
    Proc Natl Acad Sci U S A 105:10221-6. 2008
    ..As proof-of-principle we chose to target the interaction of the chemokines CCL22 and CCL17 with their receptor CCR4. CCR4 was posited as an adjuvant target based on its expression on CD4(+)CD25(+) regulatory T cells (Tregs), which ..
  66. pmc CC chemokine receptor 4 modulates Toll-like receptor 9-mediated innate immunity and signaling
    Makoto Ishii
    Immunology Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Eur J Immunol 38:2290-302. 2008
    The present study addressed the modulatory role of CC chemokine receptor 4 (CCR4) in Toll-like receptor (TLR) 9-mediated innate immunity and explored the underlying molecular mechanisms...
  67. pmc Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus
    Jun Abe
    Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 173:1682-92. 2008
    ..Taken together, we conclude that T(reg) cells in BWF1 mice are not predisposed to functional incompetence but rather are present in a highly activated state...
  68. pmc Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response
    Nan Zhang
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Immunity 30:458-69. 2009
    ..This process was dependent on the chemokine receptors CCR2, CCR4, and CCR5 and P- and E-selectin ligands...
  69. doi Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions
    Toshiharu Onodera
    Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Suita, Japan
    J Immunol 183:5608-14. 2009
    ..We also found that the MLN DCs produced CCL22, which can attract Tregs via CCR4, and that the phagocytosis of autologous apoptotic cells induced CCL22 expression in CCL22 mRNA-negative DCs...
  70. pmc The BTG2 protein is a general activator of mRNA deadenylation
    Fabienne Mauxion
    CNRS, Equipe Labellisée La Ligue, Centre de Genetique Moleculaire, UPR 2167, Gif sur Yvette, France
    EMBO J 27:1039-48. 2008
    ..is required for efficient deadenylation in mammalian cells and that the deadenylase activities of both Caf1 and its Ccr4 partner are required for Btg2-induced poly(A) degradation...

Research Grants1

  1. The Role of CCR4 in Skin Lymphocyte Homing and Immunity
    James J Campbell; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Expression patterns of the chemokine receptor CCR4 and its ligand CCL17 in humans suggests that interaction between these two molecules may contribute to skin-specific T lymphocyte homing and ..