Ccnd2

Summary

Gene Symbol: Ccnd2
Description: cyclin D2
Alias: 2600016F06Rik, AI256817, BF642806, C86853, Vin-1, Vin1, cD2, G1/S-specific cyclin-D2
Species: mouse

Top Publications

  1. ncbi Genomic organization, chromosomal localization, and independent expression of human cyclin D genes
    T Inaba
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Genomics 13:565-74. 1992
  2. ncbi Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins
    Y Xiong
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724
    Genomics 13:575-84. 1992
  3. ncbi Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
    H Matsushime
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cell 65:701-13. 1991
  4. ncbi Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5
    I Lyons
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia
    Genes Dev 9:1654-66. 1995
  5. ncbi Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
    P Sicinski
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Nature 384:470-4. 1996
  6. pmc Increased expression of cyclin D2 during multiple states of growth arrest in primary and established cells
    M Meyyappan
    Departments of Medical Science, Southern Alberta Cancer Research Center, Calgary, Alberta, Canada T2N 4N1
    Mol Cell Biol 18:3163-72. 1998
  7. ncbi G1-phase regulators, cyclin D1, cyclin D2, and cyclin D3: up-regulation at gastrulation and dynamic expression during neurulation
    F Wianny
    Laboratoire de Biologie Moleculaire et Cellulaire, UMR 49 CNRS, LA INRA 913, Ecole Normale Superieure de Lyon, France
    Dev Dyn 212:49-62. 1998
  8. ncbi Cerebellar histogenesis is disturbed in mice lacking cyclin D2
    J M Huard
    Laboratory of Molecular Neurobiology and Development, Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Development 126:1927-35. 1999
  9. ncbi Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40
    E W Lam
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary s, Norfolk Place, London W2 1PG, United Kingdom
    J Biol Chem 275:3479-84. 2000
  10. ncbi Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development
    N Solvason
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304, USA
    Int Immunol 12:631-8. 2000

Research Grants

Scientific Experts

Detail Information

Publications132 found, 100 shown here

  1. ncbi Genomic organization, chromosomal localization, and independent expression of human cyclin D genes
    T Inaba
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Genomics 13:565-74. 1992
    ..The human cyclin D1 gene (approved gene symbol, CCND1) was assigned to chromosome band 11q13, cyclin D2 (CCND2) to chromosome band 12p13, and cyclin D3 (CCND3) to chromosome band 6p21...
  2. ncbi Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins
    Y Xiong
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724
    Genomics 13:575-84. 1992
    ..We now report the molecular cloning of two additional human D-type cyclin genes, CCND2 (cyclin D2) and CCND3 (cyclin D3)...
  3. ncbi Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
    H Matsushime
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cell 65:701-13. 1991
    ..The timing of p36CYL expression, its rapid turnover in the absence of CSF-1, and its phosphorylation and transient binding to a cdc2-related polypeptide suggest that CYL genes may function during S phase commitment...
  4. ncbi Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5
    I Lyons
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia
    Genes Dev 9:1654-66. 1995
    ..The data demonstrate that Nkx2-5 is essential for normal heart morphogenesis, myogenesis, and function. Furthermore, this gene is a component of a genetic pathway required for myogenic specialization of the ventricles...
  5. ncbi Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
    P Sicinski
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Nature 384:470-4. 1996
    ..The hypoplasia seen in cyclin D2(-/-) ovaries and testes prompted us to examine human cancers deriving from corresponding tissues. We find that some human ovarian and testicular tumours contain high levels of cyclin D2 messenger RNA...
  6. pmc Increased expression of cyclin D2 during multiple states of growth arrest in primary and established cells
    M Meyyappan
    Departments of Medical Science, Southern Alberta Cancer Research Center, Calgary, Alberta, Canada T2N 4N1
    Mol Cell Biol 18:3163-72. 1998
    ....
  7. ncbi G1-phase regulators, cyclin D1, cyclin D2, and cyclin D3: up-regulation at gastrulation and dynamic expression during neurulation
    F Wianny
    Laboratoire de Biologie Moleculaire et Cellulaire, UMR 49 CNRS, LA INRA 913, Ecole Normale Superieure de Lyon, France
    Dev Dyn 212:49-62. 1998
    ..In the hindbrain, cyclin D1 and D2 show distinct segment-specific restricted expression and this pattern is conserved between mouse and chick. These results strongly suggest that D-type cyclins act as developmental regulators...
  8. ncbi Cerebellar histogenesis is disturbed in mice lacking cyclin D2
    J M Huard
    Laboratory of Molecular Neurobiology and Development, Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Development 126:1927-35. 1999
    ..These results suggest that cyclin D2 is required in cerebellum not only for proliferation of the granule cell precursors but also for proper differentiation of granule and stellate interneurons...
  9. ncbi Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40
    E W Lam
    Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary s, Norfolk Place, London W2 1PG, United Kingdom
    J Biol Chem 275:3479-84. 2000
    ....
  10. ncbi Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development
    N Solvason
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304, USA
    Int Immunol 12:631-8. 2000
    ....
  11. pmc Gris1, a new common integration site in Graffi murine leukemia virus-induced leukemias: overexpression of a truncated cyclin D2 due to alternative splicing
    Catherine Denicourt
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, Universite du Quebec a Montreal, Canada
    J Virol 77:37-44. 2003
    ..1-kb transcript from the cyclin D2 gene that encodes a truncated cyclin D2 of 17 kDa. The expression of this 1.1-kb transcript is specific to tumors in which Gris1 is rearranged but is also detected at low levels in normal tissue...
  12. pmc Development of mice expressing a single D-type cyclin
    Maria A Ciemerych
    Department of Cancer Biology, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:3277-89. 2002
    ..Hence, the requirement for a particular cyclin in a given tissue is likely caused by specific transcription factors, rather than by unique properties of cyclins...
  13. ncbi Mouse development and cell proliferation in the absence of D-cyclins
    Katarzyna Kozar
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 118:477-91. 2004
    ..Lastly, we found that cells lacking D-cyclins display reduced susceptibility to the oncogenic transformation. Our results reveal the presence of alternative mechanisms that allow cell cycle progression in a cyclin D-independent fashion...
  14. ncbi GATA4 is a dosage-sensitive regulator of cardiac morphogenesis
    William T Pu
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Dev Biol 275:235-44. 2004
    ..These data demonstrate that multiple aspects of embryonic cardiac morphogenesis and function are exquisitely sensitive to small changes in GATA4 expression levels...
  15. pmc Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    Senta Georgia
    Department of Biochemistry and Molecular Biology, University of Southern California, Developmental Biology Program, Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, California 90027, USA
    J Clin Invest 114:963-8. 2004
    ....
  16. pmc The critical role of cyclin D2 in adult neurogenesis
    Anna Kowalczyk
    Department of Molecular and Cellular Neurobiology, Nencki Institute, 02 093 Warsaw, Poland
    J Cell Biol 167:209-13. 2004
    ..We describe herein that adult mice mutated in the cell cycle regulatory gene Ccnd2, encoding cyclin D2, lack newly born neurons in both of these brain structures...
  17. ncbi Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice
    Kishore B S Pasumarthi
    Wells Center for Pediatric Research and Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Ind 46202 5225, USA
    Circ Res 96:110-8. 2005
    ..These data suggested that modulation of D-type cyclins could be exploited to promote regenerative growth in injured hearts...
  18. pmc Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth
    Jake A Kushner
    Division of Endocrinology, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:3752-62. 2005
    ..Thus, cyclins D2 and D1 were essential for beta-cell expansion in adult mice. Strategies to tightly regulate D-type cyclin activity in beta cells could prevent or cure diabetes...
  19. pmc Morphogenesis of the right ventricle requires myocardial expression of Gata4
    Elisabeth M Zeisberg
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:1522-31. 2005
    ..Our results demonstrate a general role of myocardial Gata4 in regulating cardiomyocyte proliferation and a specific, stage-dependent role in regulating the morphogenesis of the RV and the atrioventricular canal...
  20. ncbi A unique function for cyclin D3 in early B cell development
    A Byron Cooper
    Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois 60637, USA
    Nat Immunol 7:489-97. 2006
    ..Here, analysis of Ccnd1(-/-), Ccnd2(-/-), Ccnd3(-/-) and Ccnd2(-/-)Ccnd3(-/-) mice showed that cyclin D3 was uniquely required for the development of ..
  21. ncbi Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets
    Sara B Glickstein
    Laboratory of Neurogenetics and Development, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cereb Cortex 17:632-42. 2007
    ..Among the cell cycle proteins, understanding of the relative roles of the G1-phase active cyclins D2 and D1 (cD2 and cD1) has been hampered by lack of data regarding their expression patterns...
  22. pmc Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2-dependent pathway
    Weiguang Zhong
    The Cardiovascular Research Laboratories, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    EMBO J 25:3869-79. 2006
    ..These data suggest that Myc is required for a normal hypertrophic response and that its growth-promoting effects are also mediated through a CycD2-dependent pathway...
  23. ncbi Can the cardiomyocyte cell cycle be reprogrammed?
    Katrina A Bicknell
    School of Pharmacy, University of Reading, PO Box 226 Whiteknights, Reading Berkshire RG6 6AP, UK
    J Mol Cell Cardiol 42:706-21. 2007
    ..The validity of therapeutic strategies that aim to reinstate the proliferative potential of cardiomyocytes to improve myocardial repair following injury will be discussed...
  24. pmc Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition
    Etsuo Susaki
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mol Cell Biol 27:4626-40. 2007
    ..These results indicate that cyclin D2 translocates p27 from the nucleus into the cytoplasm for its KPC-dependent degradation at the G(0)-G(1) transition...
  25. ncbi Human and mouse cyclin D2 splice variants: transforming activity and subcellular localization
    C Denicourt
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, Universite du Quebec a Montreal, Quebec, Canada
    Oncogene 27:1253-62. 2008
    ..Interestingly, the presence of a similar, alternatively spliced cyclin D2 mRNA was also detected in some human brain tumors...
  26. pmc Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction
    Rutger J Hassink
    Department of Cardiology, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Cardiovasc Res 78:18-25. 2008
    ..Here, we investigated the effects of this cell cycle activation on cardiac function following myocardial infarction (MI)...
  27. pmc GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium
    Anabel Rojas
    Genentech Hall, 600 16th Street, Mail Code 2240, University of California, San Francisco, San Francisco, CA 94158 2517, USA
    Mol Cell Biol 28:5420-31. 2008
    ..These findings establish Cyclin D2 and Cdk4 as direct transcriptional targets of GATA4 and support a model in which GATA4 controls cardiomyocyte proliferation by coordinately regulating numerous cell cycle genes...
  28. doi A splice variant of cyclin D2 regulates cardiomyocyte cell cycle through a novel protein aggregation pathway
    Qian Sun
    Department of Pharmacology, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, NS, B3H 1X5 Canada
    J Cell Sci 122:1563-73. 2009
    ..We show that D2SV-induced cell cycle exit can be rescued by overexpression of D-type and B-type cyclins. We suggest that protein aggregation may be a major block for cardiomyocyte cell cycle reactivation...
  29. doi New hippocampal neurons are not obligatory for memory formation; cyclin D2 knockout mice with no adult brain neurogenesis show learning
    Piotr Jaholkowski
    Laboratory of Molecular Neurobiology, Nencki Institute, Warsaw, Poland
    Learn Mem 16:439-51. 2009
    ..Our results suggest that adult brain neurogenesis is not obligatory in learning, including the kinds of learning where the role of adult neurogenesis has previously been strongly suggested...
  30. pmc Cyclin D2 protein stability is regulated in pancreatic beta-cells
    Lu Mei He
    Division of Endocrinology and Diabetes, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 23:1865-75. 2009
    ....
  31. pmc Cyclin D2 is critical for intermediate progenitor cell proliferation in the embryonic cortex
    Sara B Glickstein
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 29:9614-24. 2009
    Expression of cyclins D1 (cD1) and D2 (cD2) in ventricular zone and subventricular zone (SVZ), respectively, suggests that a switch to cD2 could be a requisite step in the generation of cortical intermediate progenitor cells (IPCs)...
  32. pmc Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen
    Frédéric Bienvenu
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 463:374-8. 2010
    ..Our approach, which we term 'genetic-proteomic', can be used to study the in vivo function of essentially any protein...
  33. doi Developmental expression of the cyclin D2 splice variant in postnatal Purkinje cells of the mouse cerebellum
    Kosuke Kajitani
    Department of Psychiatry, Sir Charles Tupper Medical Building, Dalhousie University, 5850 College Street, Halifax, Nova Scotia B3H 1X5, Canada
    Neurosci Lett 477:100-4. 2010
    ....
  34. pmc A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
    Siwanon Jirawatnotai
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 474:230-4. 2011
    ....
  35. doi Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning ability
    Paulina Jedynak
    Laboratory of Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St, 02 093 Warsaw, Poland
    Behav Brain Res 227:159-66. 2012
    ..In our studies, we employed cyclin D2 gene knockout (cD2 KO) mice showing impaired neurogenesis as well as decreased hippocampal size...
  36. pmc Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
    Abir Yamak
    Laboratory of Cardiac Development and Differentiation, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    Am J Physiol Heart Circ Physiol 303:H1057-66. 2012
    ..Search for GATA4 targets/effectors revealed cyclin D(2) (CD2), a member of the D-type cyclins (D(1), D(2), and D(3)) that play a vital role in cell growth and differentiation ..
  37. doi Cyclin D2 knockout mice with depleted adult neurogenesis learn Barnes maze task
    Anja Urbach
    Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany
    Behav Neurosci 127:1-8. 2013
    ..In this work, however, we demonstrate adult cyclin D2 knockout (cD2 KO) mice, which lack adult hippocampal neurogenesis, are able to learn a spatial version of the Barnes maze...
  38. doi Impaired long-term memory retention: common denominator for acutely or genetically reduced hippocampal neurogenesis in adult mice
    Nada M B Ben Abdallah
    Department of Molecular Neurology, University Hospital Erlangen, Germany
    Behav Brain Res 252:275-86. 2013
    ..In contrast, spatial long-term memory retention is consistently altered after both approaches suggesting a plausible implication of hippocampal neurogenesis in this cognitive process...
  39. ncbi Elimination of cyclin D1 in vertebrate cells leads to an altered cell cycle phenotype, which is rescued by overexpression of murine cyclins D1, D2, or D3 but not by a mutant cyclin D1
    J M Lahti
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 272:10859-69. 1997
    ..Thus, there may be distinct differences in cyclin D1 complexes and/or its target(s) in proliferating and apoptotic DT40 lymphoma B-cells...
  40. ncbi Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity
    Szabolcs Fatrai
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetes 55:318-25. 2006
    ..These data also indicate that alteration in levels of these cell cycle components could affect the maintenance of beta-cell mass in basal states and the adaptation of beta-cells to pathological states resulting in diabetes...
  41. pmc Canonical Wnt signaling functions in second heart field to promote right ventricular growth
    Di Ai
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:9319-24. 2007
    ..Our findings reveal that Wnt signaling plays a major positive role in promoting growth and diversification of SHF precursors into right ventricular and interventricular myocardium...
  42. ncbi MN20, a D2 cyclin, is transiently expressed in selected neural populations during embryogenesis
    M E Ross
    Department of Neurology, University of Minnesota, Minneapolis 55455, USA
    J Neurosci 16:210-9. 1996
    ....
  43. pmc Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development
    P Zhang
    Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York 10461 USA
    Genes Dev 12:3162-7. 1998
    ..These studies demonstrate that p27(KIP1) and p57(KIP2) are critical terminal effectors of signal transduction pathways that control cell differentiation...
  44. ncbi Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development
    R N Freiman
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720 3204, USA
    Science 293:2084-7. 2001
    ....
  45. pmc N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation
    Paul S Knoepfler
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 16:2699-712. 2002
    ..Its effects on proliferation and differentiation appear due, at least in part, to down-regulation of a specific subset of cyclin-dependent kinase inhibitors...
  46. pmc Early embryonic death in mice lacking the beta-catenin-binding protein Duplin
    Masaaki Nishiyama
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582, Japan
    Mol Cell Biol 24:8386-94. 2004
    ..These results suggest that Duplin plays an indispensable role, likely by a mechanism independent of inhibition of Wnt signaling, in mouse embryonic growth and differentiation at an early developmental stage...
  47. ncbi Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
    Samantha Cicero
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 25:9658-68. 2005
    ..These data indicate that Cdk5 is necessary for both neuronal differentiation and cell cycle inhibition...
  48. ncbi Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas
    Alessandra Strom
    Department of Genetic Medicine and Development, University of Geneva Faculty of Medicine, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Development 134:2719-25. 2007
    ..This provides new insights into the mechanisms of tumor pathogenesis and tumor suppression in the pancreas...
  49. doi Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex
    Munekazu Komada
    Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, 23 Matsuokashimoaizuki, Eiheiji, Fukui 910 1193, Japan
    Neurosci Lett 547:87-91. 2013
    ..Our data suggest that Smoothened signaling, acting through cyclin D2, is critical for the proper development and maturation of the neocortex...
  50. doi FGF2 and insulin signaling converge to regulate cyclin D expression in multipotent neural stem cells
    Adedamola Adepoju
    National Institute for Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA University of Massachusetts School of Medicine, Amherst, Massachusetts, USA
    Stem Cells 32:770-8. 2014
    ....
  51. pmc Cyclin D2 is a GATA4 cofactor in cardiogenesis
    Abir Yamak
    Laboratory of Cardiac Development and Differentiation, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada, K1N 6N5
    Proc Natl Acad Sci U S A 111:1415-20. 2014
    ..Together, our data uncover a role for CycD2 as a cardiogenic coactivator of GATA4 and suggest a paradigm for cell-specific effects of cyclin Ds. ..
  52. pmc Fuz regulates craniofacial development through tissue specific responses to signaling factors
    Zichao Zhang
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas, United States of America
    PLoS ONE 6:e24608. 2011
    ..These data demonstrate a new model for coordination of Hh and Wnt signaling and reveal a Fuz-dependent negative feedback loop controlling Wnt/β-catenin signaling...
  53. doi Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression
    Akihiko Ishimura
    Division of Functional Genomics, Cancer Research Institute, Kanazawa University, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
    Development 139:749-59. 2012
    ..Taken together, these results suggest that Jmjd5 physiologically moderates embryonic cell proliferation through the epigenetic control of Cdkn1a expression...
  54. pmc Age-dependent kinetics of dentate gyrus neurogenesis in the absence of cyclin D2
    Anne Ansorg
    Hans Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    BMC Neurosci 13:46. 2012
    ..Among them, D-type cyclins control the exit from the G1 phase of the cell cycle. Cyclin D2 (cD2) has been shown to be required for the generation of new neurons in the neurogenic niches of the adult brain...
  55. pmc Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia
    Catherine M Sawai
    Department of Pathology and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
    Cancer Cell 22:452-65. 2012
    ..These studies identify unique functions for cyclin D3:CDK4/6 complexes and suggest potential therapeutic protocols for this devastating blood tumor...
  56. pmc Cloning of a D-type cyclin from murine erythroleukemia cells
    H Kiyokawa
    DeWitt Wallace Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY
    Proc Natl Acad Sci U S A 89:2444-7. 1992
    ..5-kilobase CYL2 transcript changes its expression during the cell cycle with a broad peak through G1 and S phases and a decrease in G2/M phases. The present findings suggest that CYL2 plays a role in the G1 to S phase progression...
  57. pmc Identification of a novel gene, Vin-1, in murine leukemia virus-induced T-cell leukemias by provirus insertional mutagenesis
    P J Tremblay
    Laboratory of Molecular Biology, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    J Virol 66:1344-53. 1992
    ..Vin-1 was found to be well conserved among mammalian species and was mapped to mouse chromosome 6, between raf and K-ras-2. Vin-1 appears to be a novel gene which may be involved in tumor development...
  58. ncbi Lens-specific expression of PDGF-A alters lens growth and development
    L W Reneker
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Dev Biol 180:554-65. 1996
    ..Elevated levels of PDGF-A enhance proliferation, but also appear to induce some aspects of the fiber cell differentiation pathway...
  59. pmc Functions of c-Jun in liver and heart development
    R Eferl
    Department of Pathology, University of Graz, A 8036 Graz, Austria
    J Cell Biol 145:1049-61. 1999
    ....
  60. ncbi CDK-independent activities of D type cyclins
    R Bernards
    Division of Molecular Carcinogenesis, Center for Biomedical Genetics, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Biochim Biophys Acta 1424:M17-22. 1999
  61. pmc Cyclin D2 overexpression in transgenic mice induces thymic and epidermal hyperplasia whereas cyclin D3 expression results only in epidermal hyperplasia
    M L Rodriguez-Puebla
    University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Am J Pathol 157:1039-50. 2000
    ..However, overexpression of each D-type cyclin produces a distinct phenotype in thymic epithelial cells...
  62. ncbi Involvement of the D-type cyclins in germ cell proliferation and differentiation in the mouse
    T L Beumer
    Department of Cell Biology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
    Biol Reprod 63:1893-8. 2000
    ..In spermatogonia, cyclins D(1) and D(3) seem to be involved in cell cycle regulation, whereas cyclin D(2) likely has a role in spermatogonial differentiation...
  63. ncbi Zic2 controls cerebellar development in cooperation with Zic1
    Jun Aruga
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 22:218-25. 2002
    ..These results indicate that Zic1 and Zic2 may have very similar functions in the regulation of cerebellar development...
  64. ncbi STAT3 down-regulates the expression of cyclin D during liver development
    Takaaki Matsui
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 277:36167-73. 2002
    ..Thus, STAT3-mediated down-regulation of cyclin D expression is rather specific to fetal hepatocytes that are undergoing maturation processes including a reduction of their proliferation potential...
  65. ncbi Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum
    Anne Lise Poguet
    Laboratoire de Biologie Moléculaire et Cellulaire de l Ecole Normale Supérieure de Lyon UMR CNRS 5665 LA INRA913, 46 Allée d ltalie 69364 Lyon CEDEX07France
    Dev Biol 254:188-99. 2003
    ....
  66. ncbi BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells
    Janet Glassford
    Cancer Research UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College School of Medicine at Hammersmith Hospital, Londom, UK
    Oncogene 22:2248-59. 2003
    ..Our present results lead us to propose a model in which the B-cell signalosome targets cyclin D2 via the Ca(2+) and PKC-dependent signalling cascades to mediate cell-cycle progression in response to BCR engagement...
  67. ncbi 4-1BB enhances CD8+ T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1
    Hyeon Woo Lee
    Immunomodulation Research Center, University of Ulsan, Ulsan, Korea
    Eur J Immunol 33:2133-41. 2003
    ..Our results suggest a role for cyclin D2, D3, and E, and p27(kip1) proteins in the 4-1BB-mediated cell cycle progression of CD8(+) T cells in vivo...
  68. ncbi Cyclin D2 controls B cell progenitor numbers
    Azim Mohamedali
    Leukaemia Sciences, Guy s, King s, St Thomas School of Medicine, Rayne Institute, 123 Coldharbour Lane, London SE5 9RS, UK
    J Leukoc Biol 74:1139-43. 2003
    ..We conclude that cyclin D2 is rate-limiting for the production of B lymphoid progenitor cells whose proliferation does not depend on BCR signaling...
  69. ncbi PITX2 is required for normal development of neurons in the mouse subthalamic nucleus and midbrain
    Donna M Martin
    Department of Pediatrics and Communicable Diseases, The University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 267:93-108. 2004
    ..Our results suggest a role for Pitx2 in regulating regionally specific terminal neuronal differentiation in the developing ventrolateral thalamus and midbrain...
  70. pmc Snail blocks the cell cycle and confers resistance to cell death
    Sonia Vega
    Instituto Cajal, Consejo Superior de Investigaciones Cieutificas, 28002 Madrid, Spain
    Genes Dev 18:1131-43. 2004
    ....
  71. ncbi Essential role of Plzf in maintenance of spermatogonial stem cells
    Jose A Costoya
    Cancer Biology and Genetics Program, Department of Pathology Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Genet 36:653-9. 2004
    ..These results identify Plzf as a spermatogonia-specific transcription factor in the testis that is required to regulate self-renewal and maintenance of the stem cell pool...
  72. ncbi Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium
    Hina W Chaudhry
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 279:35858-66. 2004
    ..These results reveal a previously unrecognized critical role for cyclin A2 in mediating cardiomyocyte mitosis, a role that may significantly impact upon clinical treatment of damaged myocardium...
  73. ncbi Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:1363-74. 2005
    ..We propose a model in which Nmyc is essential in the developing lung for maintaining a distal population of undifferentiated, proliferating progenitor cells...
  74. ncbi Gene knockouts that cause female infertility: search for novel contraceptive targets
    Rajesh K Naz
    Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Health Science Center, Morgantown, WV 26506 9186, USA
    Front Biosci 10:2447-59. 2005
    ..These molecules will provide novel targets of contraception including contraceptive vaccine development...
  75. ncbi Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
    Mark W Landis
    Molecular Oncology Research Institute and Department of Radiation Oncology, Tufts New England Medical Center, 750 Washington Street 5609, Boston, Massachusetts 02111, USA
    Cancer Cell 9:13-22. 2006
    ..These results demonstrate a differential requirement for cyclin D1-CDK4/6 kinase activity in development versus tumorigenesis and strongly support cyclin D1-dependent kinase activity as a specific therapeutic target in breast cancer...
  76. ncbi The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors
    Abeer El Wakil
    UMR CNRS 7000, Cytosquelette et Développement, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Development 133:2155-65. 2006
    ..Hence, our data have provided evidence for the ability of Gata2 to inhibit the proliferation of neural progenitors, and they further suggest that, in this regard, Gata2 can operate independently of neuronal differentiation...
  77. ncbi The roof plate regulates cerebellar cell-type specification and proliferation
    Victor V Chizhikov
    Department of Human Genetics, University of Chicago, 920 E 58th Street, CLSC 319 Chicago, IL 60637, USA
    Development 133:2793-804. 2006
    ..Thus, in addition to the isthmus, the roof plate represents an important signaling center controlling multiple aspects of cerebellar patterning...
  78. pmc Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes
    Ewa Sicinska
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 26:8052-60. 2006
    ..Collectively, these results demonstrate that cyclin D3 is an essential cell cycle recipient of G-CSF signaling, and they provide a molecular link of how G-CSF-dependent signaling triggers cell proliferation...
  79. ncbi Cyclin D2 and cyclin D3 play opposite roles in mouse skin carcinogenesis
    P Rojas
    Department of Carcinogenesis, Science Park Research Division, MD Anderson Cancer Center, Smithville, TX, USA
    Oncogene 26:1723-30. 2007
    ..We conclude that cyclin D3 and cyclin D2 play opposite roles in mouse skin tumor development and that the suppressive activity of cyclin D3 is associated with cyclin D2 downregulation...
  80. pmc Hes1 is required for pituitary growth and melanotrope specification
    Lori T Raetzman
    University of Michigan, Ann Arbor 48109 0618, USA
    Dev Biol 304:455-66. 2007
    ..These results demonstrate that Notch signaling plays multiple roles in pituitary development, influencing precursor number, organ size, cell differentiation and ultimately cell fate...
  81. ncbi GSK-3beta mediates in the progesterone inhibition of estrogen induced cyclin D2 nuclear localization and cell proliferation in cyclin D1-/- mouse uterine epithelium
    Yuxiang Wang
    School of Life Science and National Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200433, PR China
    FEBS Lett 581:3069-75. 2007
    ..Our results indicate that GSK-3beta is a major target of E(2) and P(4) in regulation of cyclin D2 localization in the mouse uterine epithelium...
  82. pmc COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling
    Andrea Faedo
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94158, USA
    Cereb Cortex 18:2117-31. 2008
    ..We suggest that COUP-TFI controls these processes by repressing Mapk/Erk, Akt, and beta-catenin signaling...
  83. doi Crucial roles of D-type cyclins in the early stage of adipocyte differentiation
    Tomoaki Hishida
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Biochem Biophys Res Commun 370:289-94. 2008
    ..Each of the D-type cyclins seems to play a crucial role in adipocyte differentiation by regulating MCE...
  84. doi Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
    Sven Falk
    Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Cell Stem Cell 2:472-83. 2008
    ..Thus, TGF-beta signaling controls the size of a specific brain area, the dorsal midbrain, by antagonizing canonical Wnt signaling and negatively regulating self-renewal of neuroepithelial stem cells...
  85. pmc Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity
    Hajira B Koeller
    Graduate Program in Neuroscience, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Avenue, Box 239, New York, NY 10065, USA
    Neurobiol Dis 31:230-41. 2008
    ..These findings suggest that basal cD1 expression may render hippocampal circuits more susceptible to particular epileptogenic agents and excitotoxic cell death, though cD1 is not a direct precipitant in apoptosis...
  86. pmc Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 136:1387-96. 2009
    ..palatal mesenchyme to regulate palatal mesenchyme cell proliferation through maintenance of cyclin D1 (Ccnd1) and Ccnd2 expression...
  87. pmc The notch target gene HES1 regulates cell cycle inhibitor expression in the developing pituitary
    Pamela Monahan
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Endocrinology 150:4386-94. 2009
    ....
  88. doi Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors
    Heidi Laine
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 337:134-46. 2010
    ..Thus, cyclin D1 critically contributes to the proliferative plasticity of supporting cells. These data suggest that targeted cyclin D1 induction in supporting cells might be an avenue for proliferative regeneration in the inner ear...
  89. pmc c-Abl tyrosine kinase regulates cardiac growth and development
    Zhaozhu Qiu
    Department of Microbiology, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:1136-41. 2010
    ..Genes involved in cardiac stress and remodeling and cell cycle regulation are also up-regulated in the mutant hearts. These findings reveal an essential role for c-Abl in mammalian heart growth and development...
  90. pmc Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation
    Aki Kashiwagi
    50 Blossom Street, Thier 10, Boston, MA 02114, USA
    Mol Cell Biol 30:2799-810. 2010
    ..Collectively, our findings suggest that the calpain small subunit is essential for proper chondrocyte functions in embryonic growth plates...
  91. doi Novel role for the intraflagellar transport protein CMG-1 in regulating the transcription of cyclin-D2, E-cadherin and integrin-alpha family genes in mouse spermatocyte-derived cells
    Ken Ichiro Ohbayashi
    The Tokyo Metropolitan Institute of Medical Science, Setagaya Ku, Japan
    Genes Cells 15:699-710. 2010
    ..Based on these data, we propose that CMG-1 serves as a transcriptional regulator of proliferation and adhesion-associated genes in early stage male germ-line cells in the testis...
  92. pmc Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation
    Chinmay M Trivedi
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 19:450-9. 2010
    ..These results suggest that Gata4 is a nonhistone target of Hdac2-mediated deacetylation and that Hdac2, Hopx, and Gata4 coordinately regulate cardiac myocyte proliferation during embryonic development...
  93. doi Loss of COUP-TFI alters the balance between caudal ganglionic eminence- and medial ganglionic eminence-derived cortical interneurons and results in resistance to epilepsy
    Simona Lodato
    Telethon Institute of Genetics and Medicine, Developmental Disorders Program, and European School of Molecular Medicine, 80131 Naples, Italy
    J Neurosci 31:4650-62. 2011
    ....
  94. pmc The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors
    So Yoon Kim
    Regenerative Biology Section, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 138:1903-12. 2011
    ....
  95. pmc Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels
    Seth J Salpeter
    Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Endocrinology 152:2589-98. 2011
    ..These data challenge the standard model for regulation of cyclin D2 during the cell division cycle and suggest cyclin D2 as a molecular link between glucose levels and β-cell replication...
  96. ncbi Expression of Rb, E2F1, cdc2, and D, and B cyclins in developing spinal cord
    J Zhao
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523, USA
    Neurosci Lett 190:49-52. 1995
    ..These observations suggest that Rb and E2F1 may be involved in the early stages of neuronal differentiation in addition to the cell cycle regulation...
  97. ncbi The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation
    G Meersseman
    Department of Cell Growth, Differentiation and Development, Flanders Interuniversity Institute for Biotechnology VIB, Leuven, Belgium
    Mech Dev 61:127-40. 1997
    ..We also mapped the MusMLP gene to a region on mouse chromosome 13 that corresponds to a region on human chromosome 5q that contains cancer-related genes...
  98. ncbi A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1
    H A Kim
    Department of Cancer Biology, Dana Farber Cancer Institute, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 26:405-16. 2000
    ..Even axonal regrowth into the distal zone of a nerve crush injury is not markedly impaired in cyclin D1-/- mice...
  99. pmc Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice
    Y Geng
    Department of Cancer Biology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:194-9. 2001
    ..Here we report that ablation of p27(Kip1) restores essentially normal development in cyclin D1-deficient mice. Our results provide genetic evidence that p27(Kip1) functions downstream of cyclin D1...
  100. ncbi Cyclin D2 and p27 are tissue-specific regulators of tumorigenesis in inhibin alpha knockout mice
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 17:2053-69. 2003
    ....
  101. pmc Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia
    Erica Nieuwenhuis
    Program in Developmental Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, MARS Building, East Tower, Room 13 314, Toronto, Ontario M5G 1L7, Canada
    Mol Cell Biol 26:6609-22. 2006
    ..While functional compensation by Ptc1 might account for the lack of a strong mutant phenotype in Ptc2-deficient mice, our results suggest that normal Ptc2 function is required for adult skin homeostasis...

Research Grants12

  1. ASYMMETRICALLY EXPRESSED GENES IN DEVELOPING CEREBRUM
    Daniel Geschwind; Fiscal Year: 2003
    ..abstract_text> ..
  2. HAND GENES IN CARDIAC DEVELOPMENT
    William Pu; Fiscal Year: 2004
    ..This experience, and the information generated in this plan, will launch the applicant's career as an independent investigator. ..
  3. A Genomewide Search for Autism Susceptibilty Loci
    Daniel Geschwind; Fiscal Year: 2006
    ..All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, further enhancing the value of this resource to the community. ..
  4. The Role of Cyclin A in Cardiac Development
    HINA CHAUDHRY; Fiscal Year: 2006
    ..abstract_text> ..
  5. Pitx2 Function in Developing Mouse Brain Neurons
    Donna M Martin; Fiscal Year: 2010
    ..These results will help guide future experiments aimed at directing neural stem cell differentiation toward specific neuronal cell subtypes. ..
  6. Novel Genetic Risk Factors for Alzheimer's Disease (AD) & Frontotemporal Dementia
    Daniel Geschwind; Fiscal Year: 2009
    ..abstract_text> ..
  7. THE GENETICS OF IDIOPATHIC BASAL GANGLIA CALCIFICATION
    Daniel Geschwind; Fiscal Year: 2004
    ..Physical mapping and candidate screening for mutations will be pursued as the region is narrowed to identify the IBGC gene. A genome scan will be performed in families who are not linked to the chr.14 locus. ..
  8. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
    ..Eventually, these preclinical studies in an animal model of "former smokers" will help to evaluate the potential usefulness and also possible dosage regimens of chemopreventive agents characterized by their suppressing action. ..
  9. ROLE OF CYCLINS D2 AND D3 IN LYPHIOD CELL PROLIFERATION
    Piotr Sicinski; Fiscal Year: 2004
    ..2) To determine the consequence of combined ablation of cyclins D2 and D3 for lymphoid development. (3) To determine the role for cyclins D2 and D3 in lymphoid malignancies. ..
  10. Role of Pitx2 in the Mammalian Central Nervous System
    Donna Martin; Fiscal Year: 2005
    ..5-14.5) mouse diencephalon, 2) Develop and analyze mice with Pitx2 loss of function, and 3) Develop and analyze transgenic mice with CNS-specific Pitx2 gain of function. ..
  11. Identification of targets of FoxP2 in the brain
    Daniel Geschwind; Fiscal Year: 2006
    ..This proposal has a strong screening component in an area where no molecular mechanisms have been identified and fits well within the R21 framework. ..
  12. Immunobiological Role of Fertilization Antigen(FA-1)
    RAJESH NAZ; Fiscal Year: 2007
    ..unreadable] [unreadable]..