Ccna1

Summary

Gene Symbol: Ccna1
Description: cyclin A1
Alias: cyclin-A1
Species: mouse

Top Publications

  1. pmc Molecular interaction map of the mammalian cell cycle control and DNA repair systems
    K W Kohn
    Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Biol Cell 10:2703-34. 1999
  2. pmc Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells
    Ilona Kalaszczynska
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 138:352-65. 2009
  3. pmc Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation
    Linda Panic
    Department of Molecular Medicine and Biotechnology, School of Medicine, University of Rijeka, Brace Branchetta 20, 51000, Rijeka, Croatia
    Mol Cell Biol 26:8880-91. 2006
  4. pmc Cyclin A1-deficient mice lack histone H3 serine 10 phosphorylation and exhibit altered aurora B dynamics in late prophase of male meiosis
    Helen D Nickerson
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Biol 306:725-35. 2007
  5. ncbi Distinct roles for the mammalian A-type cyclins during oogenesis
    Jenny Liao Persson
    Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA
    Reproduction 130:411-22. 2005
  6. pmc The cyclin A1-CDK2 complex regulates DNA double-strand break repair
    Carsten Muller-Tidow
    Dept of Medicine, Hematology Oncology, University of Munster, Domagkstr 3, 48129 Munster, Germany
    Mol Cell Biol 24:8917-28. 2004
  7. ncbi Distinct regions of the mouse cyclin A1 gene, Ccna1, confer male germ-cell specific expression and enhancer function
    Karen M Lele
    The Institute of Human Nutrition, Columbia University Medical Center, New York, NY 10032, USA
    Biol Reprod 71:1340-7. 2004
  8. ncbi Cyclin A1 regulates WT1 expression in acute myeloid leukemia cells
    Utz Krug
    Department of Medicine, Hematology and Oncology, University Hospital of Munster, 48129 Munster, Germany
    Int J Oncol 34:129-36. 2009
  9. ncbi Posttranscriptional regulation of cyclin A1 and cyclin A2 during mouse oocyte meiotic maturation and preimplantation development
    D Fuchimoto
    Department of Animal Breeding, Graduate School of Life and Agricultural Science, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Biol Reprod 65:986-93. 2001
  10. pmc Sp1 transcription factor and GATA1 cis-acting elements modulate testis-specific expression of mouse cyclin A1
    Sunil K Panigrahi
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e47862. 2012

Research Grants

  1. The Role of Cyclin A1 in Acute Myeloid Leukemia
    DEBRA WOLGEMUTH; Fiscal Year: 2006
  2. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009

Scientific Experts

  • K W Kohn
  • Nikolai Timchenko
  • M Zeichner David
  • Bo Torben Porse
  • DEBRA WOLGEMUTH
  • M O Bergo
  • Alistair R R Forrest
  • E Turco
  • Carsten Muller-Tidow
  • Nicole Baumer
  • Nikki A Copeland
  • Ilona Kalaszczynska
  • Piotr Sicinski
  • Hongling Zhao
  • Wolfgang E Berdel
  • Regina Miftakhova
  • Andrew Parker
  • José Javier Otero
  • Laura Perucho
  • Satomi Kuramochi-Miyagawa
  • Tetsuo Kunieda
  • Radha Raman Pandey
  • Shimpei Kajita
  • Kouyou Akiyama
  • Jenny Liao Persson
  • Akihiko Ishimura
  • Maria A Ciemerych
  • Aiko Ikenishi
  • Erin A Greaves
  • Sunil K Panigrahi
  • Tiffany van der Meer
  • Justin F X Ainscough
  • Dawn Coverley
  • Jun Han
  • Jianning Tao
  • Utz Krug
  • E L McCoy
  • Ozanna Burnicka-Turek
  • Takuji Yoshimura
  • Qiuming Kan
  • Naoki Yamamoto
  • D Liu
  • Kentaro Kamiya
  • Mark Pilkinton
  • Helen D Nickerson
  • Yan Geng
  • Toru Nakano
  • Koichi Akashi
  • C Liao
  • Ayesha Joshi
  • Tove Berg
  • Masaki Kawamata
  • Ho Lee
  • Linda Panic
  • Sven Diederichs
  • Gabriele Kohler
  • Hubert Serve
  • Ping Ji
  • Tomoyo Sasaki
  • Stefanie Schmetsdorf
  • Glicella Salazar
  • Samantha Cicero
  • Karen M Lele
  • Katarzyna Kozar
  • Robin E Duncan
  • Conrad Nieduszynski
  • Joëlle Sobczak-Thépot
  • Yoshihiro Ito
  • William H Colledge
  • Ricardo D Coletta
  • Mark Carrington
  • Ronald R Waclaw
  • Yang Chai
  • Frederick Bauzon
  • Jinhua Cui
  • Hao Fu
  • Zhonglei Lu
  • Hongbo Wang
  • Liang Zhu
  • Jenny L Persson
  • Ian J Jackson
  • Leah Batkiewicz
  • Andreas Hedblom
  • Yuan Zhang
  • Susan Morse
  • Anette Gjörloff Wingren
  • Rachel Hardisty-Hughes
  • Anita Sjölander
  • Michael R Bowl
  • George Nicholson

Detail Information

Publications66

  1. pmc Molecular interaction map of the mammalian cell cycle control and DNA repair systems
    K W Kohn
    Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Biol Cell 10:2703-34. 1999
    ..The map shows how multiprotein complexes could assemble and function at gene promoter sites and at sites of DNA damage. It also portrays the richness of connections between the p53-Mdm2 subsystem and other parts of the network...
  2. pmc Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells
    Ilona Kalaszczynska
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 138:352-65. 2009
    ..Mammalian cells encode two A-type cyclins, testis-specific cyclin A1 and ubiquitously expressed cyclin A2...
  3. pmc Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation
    Linda Panic
    Department of Molecular Medicine and Biotechnology, School of Medicine, University of Rijeka, Brace Branchetta 20, 51000, Rijeka, Croatia
    Mol Cell Biol 26:8880-91. 2006
    ..Thus, a p53-dependent checkpoint is activated during gastrulation in response to ribosome insufficiency to prevent improper execution of the developmental program...
  4. pmc Cyclin A1-deficient mice lack histone H3 serine 10 phosphorylation and exhibit altered aurora B dynamics in late prophase of male meiosis
    Helen D Nickerson
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Biol 306:725-35. 2007
    Male mice lacking cyclin A1 protein are sterile. Their sterility results from an arrest in the meiotic cell cycle of spermatocytes, which we now identify as occurring at late diplotene, immediately before diakinesis...
  5. ncbi Distinct roles for the mammalian A-type cyclins during oogenesis
    Jenny Liao Persson
    Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA
    Reproduction 130:411-22. 2005
    There are two A-type cyclins in higher vertebrates, cyclin A1 and A2. Targeted mutagenesis has shown that cyclin A2 is essential for early embryonic development while cyclin A1 is required only for male meiosis...
  6. pmc The cyclin A1-CDK2 complex regulates DNA double-strand break repair
    Carsten Muller-Tidow
    Dept of Medicine, Hematology Oncology, University of Munster, Domagkstr 3, 48129 Munster, Germany
    Mol Cell Biol 24:8917-28. 2004
    Vertebrates express two A-type cyclins; both associate with and activate the CDK2 protein kinase. Cyclin A1 is required in the male germ line, but its molecular functions are incompletely understood...
  7. ncbi Distinct regions of the mouse cyclin A1 gene, Ccna1, confer male germ-cell specific expression and enhancer function
    Karen M Lele
    The Institute of Human Nutrition, Columbia University Medical Center, New York, NY 10032, USA
    Biol Reprod 71:1340-7. 2004
    The gene encoding mouse cyclin A1, Ccna1, is expressed at highest levels in late pachytene-diplotene spermatocytes, where it is required for meiotic cell division...
  8. ncbi Cyclin A1 regulates WT1 expression in acute myeloid leukemia cells
    Utz Krug
    Department of Medicine, Hematology and Oncology, University Hospital of Munster, 48129 Munster, Germany
    Int J Oncol 34:129-36. 2009
    b>Cyclin A1 is a cell cycle protein that is expressed in testes, brain and CD34-positive hematopoietic progenitor cells. Cyclin A1 is overexpressed in a variety of myeloid leukemic cell lines and in myeloid leukemic blasts...
  9. ncbi Posttranscriptional regulation of cyclin A1 and cyclin A2 during mouse oocyte meiotic maturation and preimplantation development
    D Fuchimoto
    Department of Animal Breeding, Graduate School of Life and Agricultural Science, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Biol Reprod 65:986-93. 2001
    ..The molecular basis for this transition, however, is poorly understood. Although cyclin A1 is proposed to regulate M phase in the meiotic cell cycle, and cyclin A2 is proposed to regulate S and M phases ..
  10. pmc Sp1 transcription factor and GATA1 cis-acting elements modulate testis-specific expression of mouse cyclin A1
    Sunil K Panigrahi
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e47862. 2012
    b>Cyclin A1 is a male germ cell-specific cell cycle regulator that is essential for spermatogenesis...
  11. ncbi A distinct cyclin A is expressed in germ cells in the mouse
    C Sweeney
    University of Cambridge, Department of Biochemistry, UK
    Development 122:53-64. 1996
    ..In the adult mouse, the expression of cyclin A1, which has greatest sequence identity with Xenopus cyclin A1, is restricted to germ cells...
  12. ncbi Cyclin A1 is required for meiosis in the male mouse
    D Liu
    Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Genet 20:377-80. 1998
    The mammalian A-type cyclin family consists of two members, cyclin A1 (encoded by Ccna1) and cyclin A2 (encoded by Ccna2). Cyclin A2 promotes both G1/S and G2/M transitions, and targeted deletion of Ccna2 in mouse is embryonic lethal3...
  13. ncbi Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage
    S E Ravnik
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, 79430, USA
    Dev Biol 207:408-18. 1999
    ..A-type cyclins during meiosis in the male, we have examined the developmental and cellular distribution of the cyclin A1 and cyclin A2 proteins, as well as their candidate cyclin-dependent kinase partners, Cdk1 and Cdk2, in the ..
  14. pmc Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis
    Hongling Zhao
    From the Department of Developmental and Molecular Biology, and Ophthalmology and Visual Sciences, and Medicine, the Albert Einstein Comprehensive Cancer Center and Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 291:10201-9. 2016
    ..These findings establish that Rb1 and Skp2 deletions are synthetic lethal and suggest how this lethal relationship might be circumvented, which could help design better therapies for pRb-deficient cancer. ..
  15. pmc Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice
    Radha Raman Pandey
    European Molecular Biology Laboratory, Grenoble Outstation and Unit for Virus Host Cell Interactions, Université Grenoble Alpes, European Molecular Biology Laboratory, Centre National de la Recherche Scientifique, 38042 Grenoble, France
    Proc Natl Acad Sci U S A 110:16492-7. 2013
    ..Cell-culture studies with the insect ortholog of TDRD12 suggest a role for the multidomain protein in mediating complex formation with other participants during secondary piRNA biogenesis. ..
  16. pmc The goya mouse mutant reveals distinct newly identified roles for MAP3K1 in the development and survival of cochlear sensory hair cells
    Andrew Parker
    MRC Mammalian Genetics Unit, MRC Harwell, Oxford, OX11 0RD, UK
    Dis Model Mech 8:1555-68. 2015
    ..In addition, MAP3K1 is revealed as a new candidate gene for human sensorineural hearing loss. ..
  17. pmc Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    H Hirai
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 15:2672-81. 1995
    ..However, introduction of a vector encoding p19 into mouse NIH 3T3 cells leads to constitutive p19 synthesis, inhibits cyclin D1-CDK4 activity in vivo, and induces G1 phase arrest...
  18. ncbi LEF1 is a critical epithelial survival factor during tooth morphogenesis
    Tomoyo Sasaki
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 278:130-43. 2005
    ..Inhibition of apoptotic activity by FGF4 rescues the tooth development in the Lef1 null mutant. Our studies suggest that LEF1 is a critical survival factor for the dental epithelial cells during tooth morphogenesis...
  19. pmc Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches
    Regina Miftakhova
    a Division of Experimental Cancer Research Department of Translational Medicine Clinical Research Center Lund University Malmö, Sweden
    Cell Cycle 14:1948-60. 2015
    ..In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their ..
  20. pmc RPLP1, a crucial ribosomal protein for embryonic development of the nervous system
    Laura Perucho
    Leibniz Institute for Age Research Fritz Lipmann Institute FLI, Jena, Germany
    PLoS ONE 9:e99956. 2014
    ..Altogether, we demonstrated that the translation "fine-tuning" exerted by Rplp1 is essential for embryonic and brain development and for proper cell proliferation...
  21. pmc A mutation in the nuclear pore complex gene Tmem48 causes gametogenesis defects in skeletal fusions with sterility (sks) mice
    Kouyou Akiyama
    From the Graduate School of Environmental and Life Science and
    J Biol Chem 288:31830-41. 2013
    ..Our finding suggested that the nuclear pore complex plays an important role in mammalian gametogenesis and skeletal development. ..
  22. pmc Cerebellar cortical lamination and foliation require cyclin A2
    José Javier Otero
    The Ohio State University College of Medicine, Department of Pathology, Division of Neuropathology, 4169 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210, USA University of California, San Francisco Department of Pathology, Division of Neuropathology, USA Electronic address
    Dev Biol 385:328-39. 2014
    ..Here, we tested requirements for cyclin A1 and cyclin A2 function in cerebellar development...
  23. pmc Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent
    Jianning Tao
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    J Bone Miner Res 25:2175-83. 2010
    ..As such, it identifies Rbpj as a specific target for manipulating Notch signaling in a cell-autonomous fashion in osteoblasts in bone diseases where Notch may be dysregulated...
  24. ncbi Cell cycle promoting activity of JunB through cyclin A activation
    Sven Andrecht
    Division for Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum Heidelberg, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Biol Chem 277:35961-8. 2002
    ..Thus, cyclin A is a direct transcriptional target of JunB driving cell proliferation...
  25. pmc Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf
    Martin O Bergo
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Clin Invest 113:539-50. 2004
    ..These studies identify Icmt as a potential target for reducing the growth of K-Ras- and B-Raf-induced malignancies...
  26. ncbi Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity
    Robin E Duncan
    Departments of Nutritional Sciences and Medical Biophysics, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    J Biol Chem 279:33079-84. 2004
    ....
  27. doi Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression
    Akihiko Ishimura
    Division of Functional Genomics, Cancer Research Institute, Kanazawa University, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
    Development 139:749-59. 2012
    ..Taken together, these results suggest that Jmjd5 physiologically moderates embryonic cell proliferation through the epigenetic control of Cdkn1a expression...
  28. pmc ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6
    Qiuming Kan
    Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:4757-62. 2008
    ..These results reveal the never anticipated function of Cdc6 and redefine its role in the control of S-phase progression in mammalian cells...
  29. doi Cell cycle regulation in mouse heart during embryonic and postnatal stages
    Aiko Ikenishi
    School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, 683 8503, Japan
    Dev Growth Differ 54:731-8. 2012
    ..The data obtained should provide a basis for the analysis of cell cycle regulation in cardiomyocytes during embryonic and postnatal stages...
  30. doi Cancer-associated variant expression and interaction of CIZ1 with cyclin A1 in differentiating male germ cells
    Erin A Greaves
    Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    J Cell Sci 125:2466-77. 2012
    ..Furthermore, we show that in these post-replicative cells, CIZ1 interacts with germ-cell-specific cyclin A1, which has been implicated in the repair of DNA double-strand breaks...
  31. doi Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes
    Takuji Yoshimura
    Supply Center of Inbred Animals of Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Dev Biol 335:216-27. 2009
    ..These observations indicate that Gtsf1/Cue110 is required for spermatogenesis and involved in retrotransposon suppression in male germ cells...
  32. ncbi Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage
    Masaki Kawamata
    Department of Molecular Biology, Graduate School of Agriculture, Tohoku University, Sendai 981 8555, Japan
    FEBS Lett 580:6442-6. 2006
    ..Absence of spermatids in a histological analysis, decreased expression of Ccna1 mRNA and the accumulation of SCP3-positive spermatocytes showed the arrest of spermatogenesis at the pachytene ..
  33. ncbi Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1
    Mark Pilkinton
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 282:168-75. 2007
    ..These data support the concept that Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and mitotic cyclins...
  34. pmc Phosphorylation of the cyclic AMP response element binding protein mediates transforming growth factor beta-induced downregulation of cyclin A in vascular smooth muscle cells
    Kentaro Kamiya
    Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY 1002, USA
    Mol Cell Biol 27:3489-98. 2007
    ..Taken together, our data indicate that phosphorylation of CREB stimulated by TGFbeta is a critical step leading to the inhibition of cyclin A expression and, thus, VSMC proliferation...
  35. ncbi Induction of apoptosis involving multiple pathways is a primary response to cyclin A1-deficiency in male meiosis
    Glicella Salazar
    Department of Genetics and Development, Institute of Human Nutrition, Center for Reproductive Sciences, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY10032, USA
    Dev Dyn 234:114-23. 2005
    The meiotic arrest in male mice null for the cyclin A1 gene (Ccna1) was associated with apoptosis of spermatocytes...
  36. ncbi Analysis of the genetic interactions between Cyclin A1, Atm and p53 during spermatogenesis
    Nicole Baumer
    Department of Medicine, Hematology and Oncology, University of Munster, Domagkstr 3, D 48129 Munster, Germany
    Asian J Androl 9:739-50. 2007
    ..To analyze the functional interactions of Cyclin with p53 and Atm in spermatogenesis and DNA double-strand break repair...
  37. doi A study of the proliferating activity in lens epithelium and the identification of tissue-type stem cells
    Naoki Yamamoto
    Laboratory of Molecular Biology and Histochemistry, Fujita Health University Joint Research Laboratory, Aichi, Japan
    Med Mol Morphol 41:83-91. 2008
    ..Considering together with results of the reactivation pattern of genes, we considered that the location of tissue-type stem cells in lens epithelium (LE) as immediately anterior to the germinative zone...
  38. doi Inactivation of insulin-like factor 6 disrupts the progression of spermatogenesis at late meiotic prophase
    Ozanna Burnicka-Turek
    Institute of Human Genetics, University of Gottingen, D 37073 Gottingen, Germany
    Endocrinology 150:4348-57. 2009
    ..These results demonstrate that INSL6 is required for the progression of spermatogenesis...
  39. pmc Function of cyclins in regulating the mitotic and meiotic cell cycles in male germ cells
    Debra J Wolgemuth
    Departments of Genetics and Development and Obstetrics and Gynecology, The Institute of Human Nutrition, The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    Cell Cycle 7:3509-13. 2008
    ..A novel, meiosis-specific function has been shown for one of the A-type cyclins, cyclin A1. Embryonic lethality has obviated understanding of the germline functions of cyclin A2 and cyclin B1, while yet ..
  40. pmc Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro
    Nikki A Copeland
    Department of Biology, University of York, Heslington, York YO10 5YW, UK
    J Cell Sci 123:1108-15. 2010
    ....
  41. pmc Expression of Six1 homeobox gene during development of the mouse submandibular salivary gland
    E L McCoy
    Program in Molecular Biology, University of Colorado School of Medicine, Denver, CO, USA
    Oral Dis 15:407-13. 2009
    ..5 (E18.5) to postnatal day 28. Additionally, we examine the role of Six1 during SSG development using Six1-deficient mice...
  42. ncbi E2F-3B is a physiological target of cyclin A
    Yiwen He
    Department of Biochemistry and Molecular Biology, University of South Florida, College of Medicine, Tampa 33612, USA
    J Biol Chem 277:23493-9. 2002
    ..Finally, in synchronized cells, we observe down-regulation of E2F-3B protein expression coincident with the up-regulation of cyclin A. We conclude that E2F-3B is a physiological target of cyclin A...
  43. ncbi Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation requires the retinoblastoma protein
    L Fromm
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Oncogene 12:69-75. 1996
    ..These results indicate that the regulated expression of multiple cell cycle regulatory genes during lens fiber cell differentiation requires the presence of pRb...
  44. ncbi Timing of the expression of enamel gene products during mouse tooth development
    M Zeichner-David
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles 90033, USA
    Int J Dev Biol 41:27-38. 1997
    ..It might also suggest a possible different role for tuftelin than nucleator of hydroxyapatite crystals...
  45. ncbi Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse development
    A D Domashenko
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Mol Reprod Dev 47:57-65. 1997
    ....
  46. pmc C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice
    N A Timchenko
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 19:2936-45. 1999
    ..The disruption of E2F-p107 complexes correlates with C/EBPalpha-mediated growth arrest of hepatocytes in newborn animals...
  47. ncbi Anchorage-dependent expression of cyclin A in primary cells requires a negative DNA regulatory element and a functional Rb
    A Philips
    Institut de Genetique Moleculaire, CNRS, UMR 5535, Montpellier, France
    Oncogene 18:1819-25. 1999
    ....
  48. ncbi Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E
    M J Dealy
    Department of Biology, University of California, San Diego, California 92093 0366, USA
    Nat Genet 23:245-8. 1999
    ..We show that Cul1 is required for early mouse development and that Cul1 mutants fail to regulate the abundance of the G1 cyclin, cyclin E (encoded by Ccne), during embryogenesis...
  49. ncbi A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice
    D Liu
    The Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Biol 224:388-400. 2000
    ..We have shown that in mice, targeted disruption of an A-type cyclin gene, cyclin A1, results in a block of spermatogenesis prior to the entry into metaphase I...
  50. pmc Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1
    C Liao
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:6853-8. 2001
    A mammalian A-type cyclin, cyclin A1, is highly expressed in testes of both human and mouse and targeted mutagenesis in the mouse has revealed the unique requirement for cyclin A1 in the progression of male germ cells through the meiotic ..
  51. ncbi A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1
    C Spruck
    The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Cell 7:639-50. 2001
    ..CKS1-/- mice are abnormally small, and cells derived from them proliferate poorly, particularly under limiting mitogen conditions, possibly due to elevated levels of p27Kip1...
  52. ncbi Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers
    C L Wu
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Cancer Res 61:7325-32. 2001
    ..The data provide evidence for a Cables-mediated interplay between cdk2 and Wee1 that leads to inhibition of cell growth. Conversely, loss of Cables may cause uncontrolled cell growth and enhance tumor formation...
  53. pmc Mouse emi1 has an essential function in mitotic progression during early embryogenesis
    Ho Lee
    Department of Biological Sciences, Biomedical Research Center, Korea Advanced Institute of Science and Technology, 373 1 Guseoung dong, Yuseong Gu, Daejeon 305 701, South Korea
    Mol Cell Biol 26:5373-81. 2006
    ..Our results collectively suggest that the late prophase checkpoint function of Emi1 is essential for accurate mitotic progression and embryonic viability...
  54. pmc Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set
    Alistair R R Forrest
    The Institute for Molecular Bioscience, University of Queensland, Queensland Q4072, Australia
    Genome Res 13:1366-75. 2003
    ..We identified 1415 genes with possible cell-cycle roles, and 1758 potential paralogs. We comment on the genes identified in this screen and evaluate the merits of each approach...
  55. ncbi Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis
    Jun Han
    School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 261:183-96. 2003
    ..Genetic mutation of Msx1 may alternatively instruct the fate of these progenitor cells during craniofacial development...
  56. ncbi Mili, a mammalian member of piwi family gene, is essential for spermatogenesis
    Satomi Kuramochi-Miyagawa
    Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Development 131:839-49. 2004
    ..These data indicate that MILI is essential for the differentiation of spermatocytes...
  57. ncbi Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice
    Tiffany van der Meer
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
    Reproduction 127:503-11. 2004
    ..The cyclin A1 gene (Ccna1) is expressed during meiosis and is required for spermatogenesis...
  58. pmc The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1
    Ricardo D Coletta
    Department of Obstetrics and Gynecology, University Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:6478-83. 2004
    ..Here we show that the tissue-restricted cyclin A1 is a transcriptional target of the Six1 homeoprotein...
  59. ncbi Patterns of expression of cyclins A, B1, D, E and cdk 2 in preimplantation mouse embryos
    Ronald R Waclaw
    Department of Biology, Ball State University, Muncie, Indiana, USA
    Zygote 12:19-30. 2004
    ..Cdk 2 was present at consistent levels during G1 and S phases of all three cell cycles declining slightly in G2...
  60. ncbi Mouse development and cell proliferation in the absence of D-cyclins
    Katarzyna Kozar
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 118:477-91. 2004
    ..Lastly, we found that cells lacking D-cyclins display reduced susceptibility to the oncogenic transformation. Our results reveal the presence of alternative mechanisms that allow cell cycle progression in a cyclin D-independent fashion...
  61. ncbi Expression of cell cycle-related proteins in developing and adult mouse hippocampus
    Stefanie Schmetsdorf
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Int J Dev Neurosci 23:101-12. 2005
    ..Thus, they may have supplementary functions in differentiated neurons that might be associated with neuronal plasticity...
  62. ncbi Cell cycle in mouse development
    Maria A Ciemerych
    Department of Embryology, Institute of Zoology, Faculty of Biology, Warsaw University, Miecznikowa 1, 02 096 Warsaw, Poland
    Oncogene 24:2877-98. 2005
    ..Our text is meant to provide examples of the recent experiments, rather than to supply an extensive and complete list...
  63. ncbi Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
    Samantha Cicero
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 25:9658-68. 2005
    ..These data indicate that Cdk5 is necessary for both neuronal differentiation and cell cycle inhibition...
  64. pmc The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo
    Bo Torben Porse
    Section for Gene Therapy Research, Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark
    Mol Cell Biol 26:1028-37. 2006
    ..Surprisingly, control experiments performed in C/EBPalpha null fetal livers yielded similar results...
  65. ncbi Ectopic expression of C/EBPalpha in the lung epithelium disrupts late lung development
    Tove Berg
    Division for Respiratory Medicine, Department of Medicine, Karolinska Institute, Lung Research Laboratory L4 01, Karolinska University Hospital Solna, Stockholm SE171 76, Sweden
    Am J Physiol Lung Cell Mol Physiol 291:L683-93. 2006
    ..In conclusion, our results show a role for C/EBPalpha in lung development and suggest a function in the later stages of lung branching morphogenesis...
  66. ncbi Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis
    F Di Cunto
    Department of Genetics, Biology and Biochemistry, University of Torino, Italy
    Neuron 28:115-27. 2000
    ..Our results indicate that Citron-K is essential for cytokinesis in vivo but only in specific neuronal precursors. Moreover, they suggest a novel molecular mechanism for a subset of human malformative syndromes of the CNS...

Research Grants2

  1. The Role of Cyclin A1 in Acute Myeloid Leukemia
    DEBRA WOLGEMUTH; Fiscal Year: 2006
    ..Interestingly, in the transgenic mouse model and in human NB4 cells, the localization of cyclin A1 is predominantly cytoplasmic, distinct from its nuclear localization in germ cells...
  2. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009
    ..Based on data obtained in this project, we are planning to start developing a strategy to correct liver proliferation in elderly. ..