Genomes and Genes
Gene Symbol: Cckar
Description: cholecystokinin A receptor
Alias: AW106902, CCK-A receptor, CCK-AR, CCK1-R, cholecystokinin receptor type A, cholecystokinin-1 receptor
- CCK(1) receptor is essential for normal meal patterning in mice fed high fat dietMichael J Donovan
Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, California 95616, United States
Physiol Behav 92:969-74. 2007..These results suggest that the CCK(1)R is involved in regulating caloric intake on a meal to meal basis, but that other factors are responsible for regulation of daily food intake...
- Murine prenatal expression of cholecystokinin in neural crest, enteric neurons, and enteroendocrine cellsJ M Lay
Graduate Program in Cellular and Molecular Biology, The University of Michigan, Ann Arbor 48109 0622, USA
Dev Dyn 216:190-200. 1999..5, suggesting that CCK signaling is established early in mouse development. Dev Dyn 1999;216:190-200...
- Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptorKyoko Miyasaka
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
J Nutr 132:739-41. 2002..Energy metabolism and energy turnover were increased in mice with a disruption of the CCK-BR gene, although the underlying mechanism is unknown...
- Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasisDavid Q H Wang
Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA
J Clin Invest 114:521-8. 2004....
- Molecular structure of the mouse CCK-A receptor geneK A Lacourse
Department of Physiology, The University of Michigan, Ann Arbor 48109 0622, USA
Biochem Biophys Res Commun 236:630-5. 1997We have cloned the mouse CCK-A receptor gene (Cckar), determined its nucleotide sequence, and analyzed its expression. The receptor protein is encoded in five exons distributed over 9 kb of genomic DNA...
- Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neuronsShahid Mohammad
Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku, Toyama City, Toyama 930 8555, Japan
J Biol Chem 287:39391-401. 2012..Compensatory CCK signaling via CCK-2 receptors in CCK1R(-/-) mice shed light on currently controversial satiety-controlling mechanisms...
- Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neuronsPaolo Giacobini
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4156, USA
J Neurosci 24:4737-48. 2004....
- Plasminogen activator inhibitor-1 production is pathogenetic in experimental murine diabetic renal diseaseM Lassila
The Baker Heart Research Institute, Vascular Division, Danielle Alberti Memorial Centre for Diabetes Complications, Melbourne, Victoria, Australia
Diabetologia 50:1315-26. 2007..It is upregulated in experimental and human diabetic nephropathy. These studies assessed the effect of PAI-1 deficiency and overproduction on renal disease in experimental diabetes...
- Role of CCK-A receptor for pancreatic function in mice: a study in CCK-A receptor knockout miceSoichi Takiguchi
Division of Chemotherapy, National Kyushu Cancer Center, Minamiku Fukuoka, Japan
Pancreas 24:276-83. 2002..The CCK receptors can be pharmacologically subdivided into two subtypes: CCK-A and CCK-B. CCK-A receptor is enriched in the pancreas of mice...
- Structure and developmental expression of the mouse CCK-B receptor geneJ M Lay
Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor 48109 0622, USA
Biochem Biophys Res Commun 272:837-42. 2000..The expression pattern was similar to the adult pattern, suggesting that receptor transcription is an early event in gastrointestinal development...
- Lack of ghrelin secretion in response to fasting in cholecystokinin-A (-1), -B (-2) receptor-deficient miceChihiro Sakurai
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173 0015 Japan
J Physiol Sci 56:441-7. 2006..In conclusion, CCK-AR(-/-)BR(-/-) mice showed lower food intake as well as lower response to exogenous ghrelin, and a lower plasma ghrelin level after fasting, though which receptor is more important is unknown...
- Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterizationP Carmeliet
Whitehead Institute for Biomedical Sciences, Cambridge, Massachusetts 02139 4307
J Clin Invest 92:2746-55. 1993..PAI-1-/- mice were viable, produced similar sizes of litters as PAI-1+/+ mice, and showed no apparent macroscopic or microscopic histological abnormalities...
- Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptorsSheng Bi
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
Am J Physiol Regul Integr Comp Physiol 293:R55-63. 2007..Together, these data provide further evidence for differential roles of CCK1 receptors in the controls of food intake and body weight in rats and mice...
- Infant satiety depends on transient expression of cholecystokinin-1 receptors on ependymal cells lining the third ventricle in miceTomoya Ozaki
1Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku, Toyama 930 8555, Japan
J Physiol 591:1295-312. 2013..Hence, we demonstrate de novo functions of ependymal CCK-1 receptors and reveal a new aspect of infant satiety-controlling mechanisms...
- Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient miceLéa Ritie
INSERM, U682, Strasbourg, France Univ de Strasbourg, France
PLoS ONE 7:e37710. 2012..Thus deregulated adhesion to laminin-511 may be instrumental in diseases such as human pathologies of the gut where laminin-511 is abnormally expressed as it is shown here...
- Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti-inflammatory effect of cholecystokininSatoshi Miyamoto
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Diabetes 61:897-907. 2012..These results suggest that CCK suppresses the activation of macrophage and expression of proinflammatory genes in diabetic kidney. Our findings may provide a novel strategy of therapy for the early stage of diabetic nephropathy...
- Modular genetic control of sexually dimorphic behaviorsXiaohong Xu
Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
Cell 148:596-607. 2012..Indeed, we find that mice with targeted disruptions of each of four of these genes (Brs3, Cckar, Irs4, Sytl4) exhibit extremely specific deficits in sex specific behaviors, with single genes controlling the ..
- Roles of dorsomedial hypothalamic cholecystokinin signaling in the controls of meal patterns and glucose homeostasisGuangjing Zhu
Department of Physiology and Pathophysiology, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi, 710061, China
Physiol Behav 105:234-41. 2012..Our study also shows a novel role of DMH CCK signaling in glucose homeostasis...
- Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxietyHeng Li
Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8553, Japan
Behav Brain Res 237:325-32. 2013..The present study also proposed a possibility that cortical EEG is useful for assessing anxiety...
- New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred miceMalcolm A Lyons
Jackson Laboratory, Bar Harbor, Maine 04609, USA
Physiol Genomics 14:225-39. 2003..Our work continues to demonstrate the genetic complexity and to elucidate the pathophysiology of cholesterol gallstone formation. It should facilitate the development of new approaches for treating this common human disorder...
- Cholecystokinin-A receptors regulate photic input pathways to the circadian clockTakao Shimazoe
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
FASEB J 22:1479-90. 2008..These data indicate a novel function of CCK-A receptors in the nonimage-forming photoreception presumably via amacrine cell-mediated signal transduction pathways...
- Involvement of apolipoprotein A-IV and cholecystokinin1 receptors in exogenous peptide YY3 36-induced stimulation of intestinal feedbackK L Whited
Department of Anatomy, Physiology, and Cell Biology, University of California Davis, Davis, CA 95616, USA
Endocrinology 148:4695-703. 2007..The data suggest a role for apo A-IV and the CCK(1)R in PYY(3-36)-induced activation of the vagal afferent pathway and inhibition of gastric emptying, but this is likely not the pathway mediating the effects of PYY(3-36) on food intake...
- Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strainsThomas N Ferraro
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3404, USA
Physiol Genomics 31:458-62. 2007....
- Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitaryHyun Joon Kim
Division of Clinical and Reproductive Sciences, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
J Endocrinol 195:393-405. 2007..Taken together, this study finds CCK-AR to be an ERalpha downstream gene in the pituitary and suggests that CCK-AR may play a role in the estrogen sensitization of the pituitary response to GnRH...
- Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligandsShuzhen Hao
Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Am J Physiol Regul Integr Comp Physiol 294:R33-8. 2008..T2Rs may regulate GI function via release of regulatory peptides and activation of the vagal reflex pathway...
- Profiling CCK-mediated pancreatic growth: the dynamic genetic program and the role of STATs as potential regulatorsGrzegorz T Gurda
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0622, USA
Physiol Genomics 44:14-24. 2012....
- Effect of ghrelin receptor antagonist on meal patterns in cholecystokinin type 1 receptor null miceJennifer Lee
Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, UC Davis, Davis, CA 95616, USA
Physiol Behav 103:181-7. 2011..The site of action of ghrelin receptors is unclear, but may involve an increase in expression of CART peptide in VAN in HF-fed CCK₁R⁻/⁻ mice...
- Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1Steffen Wolfgang Schubert
Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
J Biol Chem 283:5460-5. 2008..5. Our data demonstrate for the first time that genes encoding key regulators of placental tissue formation and architecture are regulated by GCMa...
- Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrainDavor Stanic
Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
Proc Natl Acad Sci U S A 105:3610-5. 2008..These findings suggest that both NPY and CCK through their receptors help to regulate the proliferation of precursor cells, the amount of neuroblast cells in the SVZ and RMS, and influence the differentiation of OB interneurons...
- Gastric acid secretion in cholecystokinin-1 receptor, -2 receptor, and -1, -2 receptor gene knockout miceSetsuko Kanai
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, 173 0015, Japan
J Physiol Sci 59:23-9. 2009..In conclusion, CCK-2R is necessary to respond to carbachol as well as to produce the maximal acid secretion, while the role of CCK-1R in acid secretion is less important...
- Cholecystokinin directly inhibits neuronal activity of primary gonadotropin-releasing hormone cells through cholecystokinin-1 receptorPaolo Giacobini
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3714, USA
Endocrinology 148:63-71. 2007..This study provides evidence that CCK acts directly on GnRH-1 neurons to attenuate GnRH-1 neuronal activity via CCK-1R activation...
- Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteinsR T Williams
Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria 3052, Australia
Biochem J 357:673-85. 2001..This association into oligomers in vivo indicates a possible functional interaction between STIM1 and STIM2. The structural similarities between STIM1, STIM2 and D-STIM suggest conserved biological functions...
- Localization of the murine cholecystokinin A and B receptor genesL C Samuelson
Department of Physiology, University of Michigan, Ann Arbor 48109 0622, USA
Mamm Genome 6:242-6. 1995..The CCKA receptor gene (Cckar) mapped to mouse Chromosome (Chr) 5, in tight linkage with the DNA marker D5Bir8...
- Species differences between rat and mouse CCKA receptors determine the divergent acinar cell response to the cholecystokinin analog JMV-180B Ji
Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109 0622 and Tupper Research Institute, New England Medical Center, Boston, Massachusetts 02111, USA
J Biol Chem 275:19115-20. 2000..These data suggest that species differences in the CCK(A) receptor of rats and mice account for the observed divergence in the acinar cell response to JMV-180...
- Analyses of proteins involved in vesicular trafficking in platelets of mouse models of Hermansky Pudlak syndromeB Richards-Smith
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Mol Genet Metab 68:14-23. 1999..The Snap23 gene was mapped to mouse chromosome 5, demonstrating it cannot encode the gm gene, which maps to chromosome 14. It is likely therefore that the gm gene functions upstream of SNAP-23 in vesicular trafficking...
- The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weightA S Kopin
Department of Medicine, GRASP Digestive Disease Center, Tupper Research Institute, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Clin Invest 103:383-91. 1999..Our results suggest that although cholecystokinin plays a role in the short-term inhibition of food intake, this pathway is not essential for the long-term maintenance of body weight...
- Extension of conserved regions in the rat and mouse genomes by chromosomal assignments of 29 rat genesZ Cui
Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan
Exp Anim 47:83-8. 1998..In addition, four conserved regions were newly revealed. The method described in this study appears to be simple and efficient for constructing a whole genome comparative map of the rat and mouse...
- Mouse cholecystokinin type-A receptor gene and its structural analysisY Takata
Division of Chemotherapy, National Kyushu Cancer Center, Fukuoka, Japan
Gene 187:267-71. 1997..The shorter isoform may encode an 48 amino acid open reading frame due to frameshift of translation. These two mRNA isoforms were expressed equally in the mouse gallbladders...
- Genomic organization and chromosomal localization of the mouse Bp3 gene, a member of the CD38/ADP-ribosyl cyclase familyC Dong
University of Alabama at Birmingham, 378 WTI, 1824 6th Avenue South, Birmingham, AL 35294, USA
Immunogenetics 45:35-43. 1996..Consensus motifs for cytokine responsive factors NF-IL6/C-EBP, H-APF-1/APRF, and AP-1 are also present in the flanking region, and interleukin-6 treatment enhances expression of the Bp3 antigen by a myeloblastoid cell line...
- The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identityC L Pin
Department of Paediatrics, Child Health Research Institute, University of Western Ontario, London, Ontario N6C 2V5, Canada
J Cell Biol 155:519-30. 2001..Based on these observations, we propose that Mist1(KO) mice represent a new genetic model for chronic pancreas injury and that the Mist1 protein serves as a key regulator of acinar cell function, stability, and identity...
- Anxiety-related behaviors in cholecystokinin-A, B, and AB receptor gene knockout mice in the plus-mazeKyoko Miyasaka
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho Itabashiku, l73 0015, Tokyo, Japan
Neurosci Lett 335:115-8. 2002..We therefore conclude that a lack of CCK-BR increases the anxiety-related behavior of the mouse in the elevated plus- maze...
- Association of cholecystokinin A receptor gene polymorphism with cholelithiasis and the molecular mechanisms of this polymorphismKyoko Miyasaka
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashiku, Tokyo 173 0015, Japan
J Gastroenterol 37:102-6. 2002..The involvement of CCK-AR in gallstone formation was confirmed using CCK-AR gene knockout mice...
- Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric functionK L Whited
Department of Anatomy, Physiology, and Cell Biology, School of Vetinary Medicine, University of California, Davis School of Veterinary Medicine, Davis, CA 95616, USA
Am J Physiol Gastrointest Liver Physiol 291:G156-62. 2006..Thus, despite a relatively normal phenotype, intestinal feedback in response to lipid is severely impaired in these mice...
- Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptorGéraldine Ibarz
Laboratoire des Aminoacides, Peptides et Protéines LAPP, CNRS UMR 5810, UMI et UMII, UFR Pharmacie, 15, Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
Br J Pharmacol 147:951-8. 2006In cells overexpressing active MEKK1 to enhance c-Jun trans-activation, expression of rat cholecystokinin 1 receptor increased the activity of c-Jun while in the same experimental conditions overexpression of mouse cholecystokinin 1 ..
- Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptorNatsuko Tsujino
Department of Molecular Pharmacology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
J Neurosci 25:7459-69. 2005..The evidence presented here expands our understanding of the regulation of orexin neurons and the physiological role of CCK in the CNS...
- Differences in partial agonist action at cholecystokinin receptors of mouse and rat are dependent on parameters extrinsic to receptor structure: molecular cloning, expression and functional characterization of the mouse type A cholecystokinin receptorD Ghanekar
Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Pharmacol Exp Ther 282:1206-12. 1997..Receptor microenvironment makes an important, yet often ignored, contribution to receptor function...
- Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperatureShigeki Nomoto
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashiku Tokyo 173 0015, Japan
Am J Physiol Regul Integr Comp Physiol 287:R556-61. 2004..Mice without CCK-AR showed larger hysteresis than mice with CCK-AR. From these results, we conclude that the lack of CCK-AR causes homeostasis of T(c) in rats and mice to deteriorate...
- Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor: a study of CCK-A,B, and AB receptor gene knockout miceKyoko Miyasaka
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
J Gastroenterol 39:319-23. 2004..We examined whether gastric emptying of a nonnutrient liquid load was modified in CCK-AR, BR, and ARBR gene knockout mice...
- Differential roles for cholecystokinin a receptors in energy balance in rats and miceSheng Bi
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Endocrinology 145:3873-80. 2004..The deficit in CCK's action in the control of DMH NPY gene expression may play a major role in the obese phenotype in OLETF rats...
- Lack of cholecystokinin-A receptor enhanced gallstone formation: a study in CCK-A receptor gene knockout miceNorikazu Sato
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashiku, Tokyo 173 0015, Japan
Dig Dis Sci 48:1944-7. 2003..Sludge and gallstone formation were not observed at 6 months of age. In conclusion, deteriorated gallbladder contraction due to a lack of CCK-AR favored gallstone formation after the middle age of life...
- Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouseK Huppi
Molecular Genetics Section, Laboratory of Genetics, NCI NIH, Bethesda, Maryland 20892, USA
Genomics 25:727-9. 1995Receptors for cholcystokinin (CCK) can be pharmacologically classified into at least two distinct subtypes, CCKAR and CCKBR...
- Dorsomedial Hypothalamic Pathways and Energy BalanceSheng Bi; Fiscal Year: 2005..Together, these neurochemical and functional demonstrations will provide a clear view of the role of the DMH in energy balance ..
- Dorsomedial Hypothalamic Signaling Pathways and Energy BalanceSheng Bi; Fiscal Year: 2010..Overall, the elucidation of the actions of these DMH peptide systems in feeding and body weight control would significantly advance our understanding of the role of this hypothalamic nucleus in maintaining energy homeostasis. ..
- PHARMACOGENOMIC STUDY OF ANTICONVULSANT THERAPYTHOMAS FERRARO; Fiscal Year: 2003....