caveolin 1

Summary

Gene Symbol: caveolin 1
Description: caveolin 1, caveolae protein
Alias: Cav, Cav-1, caveolin-1, caveolin, caveolae protein 1, caveolin, caveolae protein, 22 kDa
Species: mouse

Top Publications

  1. pmc Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis
    Guangwen Cao
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Pathol 162:1241-8. 2003
  2. pmc Phosphorylation of caveolin-1 regulates oxidant-induced pulmonary vascular permeability via paracellular and transcellular pathways
    Yu Sun
    Department of Pharmacology m c 868, University of Illinois at Chicago, Chicago, IL 60612, USA
    Circ Res 105:676-85, 15 p following 685. 2009
  3. pmc PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function
    Michelle M Hill
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    Cell 132:113-24. 2008
  4. pmc Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice
    You Yang Zhao
    University of California at San Diego, Institute of Molecular Medicine, 9500 Gilman Drive, BSB 0623, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 99:11375-80. 2002
  5. pmc Distinct roles of endothelial and adipocyte caveolin-1 in macrophage infiltration and adipose tissue metabolic activity
    Nolwenn Briand
    Centre de Recherche des Cordeliers, INSERM, U872, Paris, France
    Diabetes 60:448-53. 2011
  6. pmc Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 189:111-26. 2010
  7. ncbi Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    M Drab
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, D 01307 Dresden, Germany
    Science 293:2449-52. 2001
  8. pmc Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1
    Jacky G Goetz
    Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Cell Biol 180:1261-75. 2008
  9. doi Caveolae and caveolin-1 are implicated in 1alpha,25(OH)2-vitamin D3-dependent modulation of Src, MAPK cascades and VDR localization in skeletal muscle cells
    Claudia Buitrago
    Departamento de Biologia, Bioquimica and Farmacia, Universidad Nacional del Sur, San Juan 670, Piso 4, Bahia Blanca 8000, Argentina
    J Steroid Biochem Mol Biol 121:169-75. 2010
  10. pmc Elevated inflammatory response in caveolin-1-deficient mice with Pseudomonas aeruginosa infection is mediated by STAT3 protein and nuclear factor kappaB (NF-kappaB)
    Kefei Yuan
    State Key Laboratory for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    J Biol Chem 286:21814-25. 2011

Detail Information

Publications199 found, 100 shown here

  1. pmc Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis
    Guangwen Cao
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Pathol 162:1241-8. 2003
    ..These results demonstrate that disruption of the Cav1 gene promotes the progressive steps required for urinary calcium stone formation and establish a new mouse model for urinary stone disease...
  2. pmc Phosphorylation of caveolin-1 regulates oxidant-induced pulmonary vascular permeability via paracellular and transcellular pathways
    Yu Sun
    Department of Pharmacology m c 868, University of Illinois at Chicago, Chicago, IL 60612, USA
    Circ Res 105:676-85, 15 p following 685. 2009
    ..Oxidants are important signaling molecules known to increase endothelial permeability, although the mechanisms underlying permeability regulation are not clear...
  3. pmc PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function
    Michelle M Hill
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    Cell 132:113-24. 2008
    ..We used comparative proteomics to identify PTRF (also called Cav-p60, Cavin) as a putative caveolar coat protein...
  4. pmc Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice
    You Yang Zhao
    University of California at San Diego, Institute of Molecular Medicine, 9500 Gilman Drive, BSB 0623, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 99:11375-80. 2002
    ..To investigate the in vivo significance of Caveolins in mammals, we generated mice deficient in the caveolin-1 (cav-1) gene and have shown that, in the absence of Cav-1, no caveolae structures were observed in several nonmuscle ..
  5. pmc Distinct roles of endothelial and adipocyte caveolin-1 in macrophage infiltration and adipose tissue metabolic activity
    Nolwenn Briand
    Centre de Recherche des Cordeliers, INSERM, U872, Paris, France
    Diabetes 60:448-53. 2011
    ..The goal of this study was to establish the relative contribution of endothelial cells and adipocytes, both highly expressing caveolin-1 to the lipoatrophic phenotype of mice with global caveolin-1 gene invalidation (Cav1-KO)...
  6. pmc Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 189:111-26. 2010
    ..These data demonstrate that MLCK activation triggers caveolin-1-dependent endocytosis of occludin to effect structural and functional tight junction regulation...
  7. ncbi Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    M Drab
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, D 01307 Dresden, Germany
    Science 293:2449-52. 2001
    ..Thus, caveolin-1 and caveolae play a fundamental role in organizing multiple signaling pathways in the cell...
  8. pmc Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1
    Jacky G Goetz
    Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Cell Biol 180:1261-75. 2008
    ..Thus, transmembrane crosstalk between the galectin lattice and pY14Cav1 promotes FA turnover by stabilizing FAK within FAs defining previously unknown, interdependent roles for galectin-3 and pY14Cav1 in tumor cell migration...
  9. doi Caveolae and caveolin-1 are implicated in 1alpha,25(OH)2-vitamin D3-dependent modulation of Src, MAPK cascades and VDR localization in skeletal muscle cells
    Claudia Buitrago
    Departamento de Biologia, Bioquimica and Farmacia, Universidad Nacional del Sur, San Juan 670, Piso 4, Bahia Blanca 8000, Argentina
    J Steroid Biochem Mol Biol 121:169-75. 2010
    ..In this work, we investigated the role of caveolae and caveolin-1 (cav-1) in 1alpha,25(OH)2D3-stimulation of c-Src and MAPKs...
  10. pmc Elevated inflammatory response in caveolin-1-deficient mice with Pseudomonas aeruginosa infection is mediated by STAT3 protein and nuclear factor kappaB (NF-kappaB)
    Kefei Yuan
    State Key Laboratory for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    J Biol Chem 286:21814-25. 2011
    Caveolin-1 (Cav-1), an important composition protein within the flask-shaped membrane invaginations termed caveolae, may play a role in host defense against infections...
  11. doi Caveolin-1 regulates BMPRII localization and signaling in vascular smooth muscle cells
    Jeffrey W Wertz
    Department of Surgery, University of Pittsburgh, BST 3, Room 6058, Pittsburgh, PA 15261, USA
    Biochem Biophys Res Commun 375:557-61. 2008
    ..Taken together, our findings establish caveolin-1 as an important regulator of downstream signaling and membrane targeting of BMPRII in vascular smooth muscle cells...
  12. ncbi Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo
    W Schubert
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:48619-22. 2001
    ..Our results indicate that gold-conjugated albumin is not endocytosed by Cav-1-deficient lung endothelial cells and remains in the blood vessel lumen; in contrast, gold-conjugated albumin was ..
  13. pmc Caveolin-1 regulates expression of junction-associated proteins in brain microvascular endothelial cells
    Li Song
    Blood Brain Barrier Laboratory, Department of Pharmacology, University of Connecticut Health Center, Farmington 06030, USA
    Blood 109:1515-23. 2007
    ..These results collectively highlight caveolin-1 loss as a critical step in CCL2-induced modulation of BMEC junctional protein expression and integrity, and possibly serve a crucial role in regulating inflammation at the BBB...
  14. pmc Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts
    Federica Sotgia
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10 Street, Philadelphia, PA 19107, USA
    Am J Pathol 174:746-61. 2009
    ..show functional inactivation of the retinoblastoma (RB) tumor suppressor and down-regulation of caveolin-1 (Cav-1) protein expression...
  15. pmc Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis
    Carlos Fernandez-Hernando
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Metab 10:48-54. 2009
    ..Here, by using endothelial cell-specific transgenesis of the caveolin-1 (Cav-1) gene in mice, we show the critical role of Cav-1 in promoting atherogenesis...
  16. pmc Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5
    Yukie Yamaguchi
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Cell Mol Med 15:957-69. 2011
    ..Since Caveolin-1 (Cav-1) has been implicated to play a role in membrane trafficking and signal transduction in tissue fibrosis, we ..
  17. pmc The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain
    Elke Burgermeister
    Department of Medicine II, Universitatsklinikum Mannheim, Universitat Heidelberg, Mannheim, Germany
    Mol Cell Biol 31:3497-510. 2011
    ..These results suggest a novel mechanism of PPARγ regulation by which Ras/MAPK inhibitors act as scaffold proteins that sequester and sensitize PPARγ to ligands, limiting proliferation of gastric epithelial cells...
  18. pmc EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization
    Björn Morén
    Medical Biochemistry and Biophysics, Laboratory for Molecular Infection Medicine, Sweden, Umea University, Umea, Sweden
    Mol Biol Cell 23:1316-29. 2012
    ..Thus, following the identification of caveolin and cavins, EHD2 constitutes a third structural component of caveolae involved in controlling the stability and turnover of this organelle...
  19. ncbi Intracellular retention of caveolin 1 in presenilin-deficient cells
    Douglas R Wood
    Department of Urology, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 280:6663-8. 2005
    ..Binding of albumin depends on intact caveolae on the cellular surface. Abnormal caveolin 1 localization in PS1/2 null cells was associated with a loss of caveolae and an absence of caveolin 1 expression ..
  20. ncbi Caveolin-1 regulates NF-kappaB activation and lung inflammatory response to sepsis induced by lipopolysaccharide
    Sean Garrean
    Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA
    J Immunol 177:4853-60. 2006
    ..Using caveolin-1-knockout (Cav-1(-/-)) mice, we addressed the role of caveolin-1 in the lung inflammatory response to sepsis induced by i.p...
  21. pmc Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice
    Takahisa Murata
    Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06511
    J Exp Med 204:2373-82. 2007
    Caveolin-1 (Cav-1) is the principal structural component of caveolae organelles in smooth muscle cells, adipocytes, fibroblasts, epithelial cells, and endothelial cells (ECs)...
  22. ncbi Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury
    Guochang Hu
    Department of Pharmacology, University of Illinois College of Medicine, 835 South Wolcott Ave, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 294:L178-86. 2008
    ..Here, using caveolin-1-null (Cav-1(-/-)) mice, we addressed the role of caveolin-1 in polymorphonuclear neutrophils (PMNs) in regulating PMN ..
  23. pmc The absence of caveolin-1 increases proliferation and anchorage- independent growth by a Rac-dependent, Erk-independent mechanism
    Ana Cerezo
    Integrin Signaling Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro 3, Madrid, Spain
    Mol Cell Biol 29:5046-59. 2009
    ..These results provide insight into the mechanisms regulating growth of cancer cells, which frequently lose Cav1 function...
  24. doi PPARgamma1-induced caveolin-1 enhances cholesterol efflux and attenuates atherosclerosis in apolipoprotein E-deficient mice
    Qin Hu
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, China
    J Vasc Res 47:69-79. 2010
    Caveolin-1 (Cav-1) may positively or negatively influence the development of atherosclerosis, depending on the cell type and the metabolic pathways regulated by this protein...
  25. pmc Caveolin-1 deficiency dampens Toll-like receptor 4 signaling through eNOS activation
    Muhammad K Mirza
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Am J Pathol 176:2344-51. 2010
    ....
  26. ncbi Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation
    Stephanos Pavlides
    Departments of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:2201-19. 2010
    b>Cav-1 (-/-) deficient stromal cells are a new genetic model for myofibroblasts and cancer-associated fibroblasts...
  27. pmc A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice
    Pascal Bernatchez
    Providence Heart and Lung Institute, St Paul s Hospital, James Hogg Research Centre, 1081 Burrard St, Room 166, Vancouver BC Canada, V6Z 1Y6
    J Clin Invest 121:3747-55. 2011
    ..Aberrant regulation of eNOS and associated NO release are directly linked with various vascular diseases. Caveolin-1 (Cav-1), the main coat protein of caveolae, is highly expressed in endothelial cells...
  28. ncbi Caveolin-1 deficiency increases cerebral ischemic injury
    Jean Francois Jasmin
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA
    Circ Res 100:721-9. 2007
    Caveolins (Cav), the principal structural proteins of the caveolar domains, have been implicated in the pathogenesis of ischemic injury...
  29. ncbi Opposing effects of protein kinase Calpha and protein kinase Cepsilon on collagen expression by human lung fibroblasts are mediated via MEK/ERK and caveolin-1 signaling
    Elena Tourkina
    Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 280:13879-87. 2005
    ..The combined results demonstrate that a branched signaling pathway involving MEK, ERK, PKCepsilon, PKCalpha, and caveolin-1 regulates collagen expression in normal lung tissue and is perturbed during fibrosis...
  30. pmc Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization
    Miguel A Del Pozo
    Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid 28029, Spain
    Nat Cell Biol 7:901-8. 2005
    ..These data define a novel molecular mechanism for growth and tumour suppression by caveolin-1...
  31. pmc Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases
    Araceli Grande-García
    Integrin Signaling Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    J Cell Biol 177:683-94. 2007
    ..These findings highlight the importance of caveolin-1 in the establishment of cell polarity during directional migration through coordination of the signaling of Src kinase and Rho GTPases...
  32. doi Nitric oxide synthases are crucially involved in the development of the severe cardiomyopathy of caveolin-1 knockout mice
    Carsten Wunderlich
    University of Technology Dresden, Department of Medicine and Cardiology, Medical Clinic, Fetscherstr 76, Dresden 01307, Germany
    Biochem Biophys Res Commun 377:769-74. 2008
    Targeted ablation of caveolin-1 (cav-1) results in a severe cardiomyopathy. How the loss of cav-1 mediates these abnormalities is currently under investigation...
  33. ncbi The lipoatrophic caveolin-1 deficient mouse model reveals autophagy in mature adipocytes
    Soazig Le Lay
    Centre de Recherche des Cordeliers, Inserm U872, Paris, France
    Autophagy 6:754-63. 2010
    ..This is the first report of a pathological situation with autophagy as an adaptative response to adipocyte failure...
  34. ncbi The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1
    Akiko Kimura
    Department of Medicine, Life Sciences Institute, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0650, USA
    J Biol Chem 277:30153-8. 2002
    ..Taken together, these data indicate that the insulin receptor directly catalyzes the tyrosine phosphorylation of caveolin...
  35. pmc Caveolin-1 and altered neuregulin signaling contribute to the pathophysiological progression of diabetic peripheral neuropathy
    James F McGuire
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas, USA
    Diabetes 58:2677-86. 2009
    ..Evaluate if Erb B2 activation and the loss of caveolin-1 (Cav1) contribute to the pathophysiological progression of diabetic peripheral neuropathy (DPN)...
  36. pmc Identification, sequence, and expression of caveolin-2 defines a caveolin gene family
    P E Scherer
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142 1479, USA
    Proc Natl Acad Sci U S A 93:131-5. 1996
    ..However, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell...
  37. ncbi Caveolin-1 is essential for liver regeneration
    Manuel A Fernandez
    Departament de Biologia Cellular, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain
    Science 313:1628-32. 2006
    ..Thus, caveolin-1 plays a crucial role in the mechanisms that coordinate lipid metabolism with the proliferative response occurring in the liver after cellular injury...
  38. doi Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling
    Charlotte L Mattsson
    Department of Physiology, The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1803:983-9. 2010
    ..Thus, in brown adipocytes, Cav1 is apparently required for an intact response to adenylyl cyclase-linked agonists/activators, whereas other signaling pathways examined function without Cav1...
  39. pmc Caveolin-1 orchestrates TCR synaptic polarity, signal specificity, and function in CD8 T cells
    Tamar Tomassian
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 187:2993-3002. 2011
    ..Alternatively, caveolin-1 ablation did not affect TCR-induced NF-κB-dependent Iκbα expression. Cav-1(-/-) mice did not efficiently promote CD8 immunity to lymphocytic choriomeningitis virus, nor did cav-1(-/-) OT-1(..
  40. doi Bile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding protein
    Elke Prade
    Department of Chemistry, Klinikum rechts der Isar, Technische Universitat Munchen, D 81675 Munich, Germany
    Mol Endocrinol 26:819-32. 2012
    ..These data indicate that bile acid-mediated down-regulation of Cav1 marks early changes in the squamous epithelium, which may contribute to onset of Barrett esophagus metaplasia and progression to BAC...
  41. ncbi Altered expression of caveolin-1 and increased cholesterol in detergent insoluble membrane fractions from liver in mice with Niemann-Pick disease type C
    W S Garver
    Angel Charity for Children Wings for Genetic Research, Section of Medical and Molecular Genetics, The University of Arizona, College of Medicine, Tucson 85724, USA
    Biochim Biophys Acta 1361:272-80. 1997
    ....
  42. ncbi The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo
    K Das
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 274:18721-8. 1999
    ..This is the first demonstration that these unusual membrane-spanning regions found in the caveolin family play a specific role in protein-protein interactions...
  43. pmc Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade
    David S Park
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Biol Cell 13:3416-30. 2002
    ..We next tested the in vivo relevance of these findings using female Cav-1 (-/-) null mice...
  44. ncbi Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression
    Mariarosaria Bucci
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples, Italy
    Arterioscler Thromb Vasc Biol 24:721-6. 2004
    ..Using non-obese diabetic mice, we have evaluated the role of the adrenergic system and eNOS on progression of the disease..
  45. ncbi Loss of caveolin-1 expression is associated with disruption of muscarinic cholinergic activities in the urinary bladder
    H Henry Lai
    Neurourology Laboratory, Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA
    Neurochem Int 45:1185-93. 2004
    ....
  46. ncbi ERM is expressed by alveolar epithelial cells in adult mouse lung and regulates caveolin-1 transcription in mouse lung epithelial cell lines
    Hasmeena Kathuria
    Department of Medicine, Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 102:13-27. 2007
    ....
  47. ncbi Differential dependence of stretch and shear stress signaling on caveolin-1 in the vascular wall
    Sebastian Albinsson
    Vascular Physiology Group, Department of Experimental Medical Science, Lund University, BMC D12, Lund SE 221 84, Sweden
    Am J Physiol Cell Physiol 294:C271-9. 2008
    The role of caveolae in stretch- versus flow-induced vascular responses was investigated using caveolin 1-deficient [knockout (KO)] mice. Portal veins were stretched longitudinally for 5 min (acute) or 72 h (organ culture)...
  48. pmc Regulation of Cripto-1 signaling and biological activity by caveolin-1 in mammary epithelial cells
    Caterina Bianco
    National Cancer Institute, Bethesda, MD 20892, USA
    Am J Pathol 172:345-57. 2008
    ..In this study, we examined the relationship between Cripto-1 and caveolin-1 (Cav-1), a membrane protein that acts as a tumor suppressor in the mammary gland...
  49. pmc Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1
    Yang Jin
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 39:171-9. 2008
    ..Here we demonstrate that caveolin-1-null mice (cav-1(-/-)) were resistant to hyperoxia-induced death and lung injury...
  50. doi Control of blood pressure variability in caveolin-1-deficient mice: role of nitric oxide identified in vivo through spectral analysis
    Fanny Desjardins
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, UCL FATH 5349, Vésale 5, 52 Avenue Mounier, 1200 Brussels, Belgium
    Cardiovasc Res 79:527-36. 2008
    In endothelial cells, caveolin-1 (cav-1) is known to negatively modulate the activation of endothelial nitric oxide synthase, a key regulator of blood pressure (BP)...
  51. pmc The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties
    O Le Saux
    Univ of Hawaii, John A Burns School of Medicine, Dept of Cell and Molecular Biology, 651 Ilalo St, BSB 222, Honolulu, HI 96813, USA
    Am J Physiol Lung Cell Mol Physiol 295:L1007-17. 2008
    ....
  52. pmc A dual role for caveolin-1 in the regulation of fibronectin matrix assembly by uPAR
    Elizabeth Monaghan-Benson
    Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cell Sci 121:3693-703. 2008
    ..These studies provide a novel paradigm for the regulation of crosstalk among integrins, growth-factor receptors and uPAR...
  53. pmc Caveolin-1-dependent apoptosis induced by fibrin degradation products
    Yi He Guo
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226 3548, USA
    Blood 113:4431-9. 2009
    ....
  54. pmc Stromal cell expression of caveolin-1 predicts outcome in breast cancer
    Erica K Sloan
    Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria, Australia, 8006
    Am J Pathol 174:2035-43. 2009
    ..These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression...
  55. doi The expression of caveolin-1 and the distribution of caveolae in the murine placenta and yolk sac: parallels to the human placenta
    S Mohanty
    Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    Placenta 31:144-50. 2010
    ..We conclude that caveolin-1 and caveolae have restricted distribution in the murine placenta and yolk sac and that this parallels the situation in human placenta...
  56. pmc MMTV promoter-regulated caveolin-1 overexpression yields defective parenchymal epithelia in multiple exocrine organs of transgenic mice
    Guang Yang
    Department of Genitourinary Medical Oncology Research, Unit 18 3, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Exp Mol Pathol 89:9-19. 2010
    Caveolin-1 (Cav-1) is a major structural protein of caveolae, specialized plasma membrane invaginations that are involved in a cell-specific fashion in diverse cell activities such as molecular transport, cell adhesion, and signal ..
  57. pmc Alterations of Na+/K+-ATPase function in caveolin-1 knockout cardiac fibroblasts
    Luis E M Quintas
    Department of Physiology and Pharmacology, College of Medicine, University of Toledo, Toledo, OH 43614 5804, USA
    J Mol Cell Cardiol 49:525-31. 2010
    ..In cardiac fibroblasts prepared from wild-type and caveolin-1 knockout [Cav-1(-/-)] mice, we found that the absence of caveolin-1 did not affect total cellular amount or surface expression of ..
  58. pmc p190 RhoGTPase-activating protein links the β1 integrin/caveolin-1 mechanosignaling complex to RhoA and actin remodeling
    Baohua Yang
    Cardiovascular Research Center, Temple University School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 31:376-83. 2011
    ..To determine whether the β1 integrin/caveolin-1 signaling complex plays a role in shear stress regulation of RhoA activity ...
  59. pmc Caveolin-1 modulates the ability of Ewing's sarcoma to metastasize
    Miguel Sáinz-Jaspeado
    Institut d Investigació Biomèdica de Bellvitge IDIBELL, Hospital Duran i Reynals 3 Planta Gran via s n Km 2, 7, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Mol Cancer Res 8:1489-500. 2010
    ....
  60. pmc Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility
    Marta Bosch
    Equip de Proliferació i Senyalització Cel lular, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    Curr Biol 21:681-6. 2011
    ..b>CAV proteins bind cholesterol, and CAV's ability to move between cellular compartments helps control intracellular ..
  61. pmc Transcriptional repression of Caveolin-1 (CAV1) gene expression by GATA-6 in bladder smooth muscle hypertrophy in mice and human beings
    Ettickan Boopathi
    Division of Urology, University of Pennsylvania, Glenolden, Pennsylvania, USA
    Am J Pathol 178:2236-51. 2011
    ..GATA-6-induced transcriptional repression represents a new regulatory mechanism of CAV1 gene expression in pathologic BSM, and may serve as a target for new therapy for BPH-induced bladder dysfunction in aging men...
  62. pmc Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator
    Ubaldo E Martinez-Outschoorn
    Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1784-93. 2011
    ..To further validate the in vivo relevance of these findings, we assessed the inflammatory status of Cav-1 (-/-) null mammary fat pads, which are a model of a bonafide autophagic microenvironment...
  63. pmc Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis
    Jacky G Goetz
    Integrin Signaling Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid 28029, Spain
    Cell 146:148-63. 2011
    ..Thus, Cav1 modulates tissue responses through force-dependent architectural regulation of the microenvironment...
  64. pmc Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance
    Kazuya Kabayama
    Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, 4 4 1, Komatsushima, Sendai 981 8558, Miyagi, Japan
    Proc Natl Acad Sci U S A 104:13678-83. 2007
    ....
  65. pmc Vascular permeability and pathological angiogenesis in caveolin-1-null mice
    Sung Hee Chang
    Center for Vascular Biology Research and the Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Pathol 175:1768-76. 2009
    ..to be the transcellular pathway by which plasma proteins cross normal capillary endothelium, but, unexpectedly, cav-1(-/-) mice, which lack caveolae, have increased permeability to plasma albumin...
  66. pmc Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice
    Terence M Williams
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Biol Cell 14:1027-42. 2003
    ..For example, the human CAV-1 gene maps to a suspected tumor suppressor locus (D7S522/7q31...
  67. pmc Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling
    John A Allen
    Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago UIC, Chicago, IL 60612 7342, USA
    Mol Pharmacol 76:1082-93. 2009
    ..It is suggested that lipid rafts/caveolae are sites that remove Galpha(s) from membrane signaling cascades and caveolins might dampen globally Galpha(s)/adenylyl cyclase/cAMP signaling...
  68. ncbi M-caveolin, a muscle-specific caveolin-related protein
    M Way
    European Molecular Biology Laboratory, Heidelberg, Germany
    FEBS Lett 376:108-12. 1995
    ..Epitope-tagged M-caveolin expressed in non-muscle cells was targetted to surface caveolae where it colocalized with endogenous VIP21-caveolin. M-caveolin may play a specialised role in the caveolae of muscle cells...
  69. pmc Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia
    Hyangkyu Lee
    Department of Molecular Pharmacology, Division of Hormone Dependent Tumor Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 161:1357-69. 2002
    Caveolin-1 (Cav-1) is the principal structural protein of caveolae membranes that are found in most cells types, including mammary epithelial cells. Recently, we mapped the human CAV1 gene to a suspected tumor suppressor locus (7q31...
  70. pmc Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli
    Scott E Woodman
    Department of Molecular Pharmacology, Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 162:2059-68. 2003
    Recent studies have shown that caveolin-1 (Cav-1) plays an important role as a regulator of angiogenesis in vitro. Here, we use Cav-1 knockout (KO) mice as a model system to examine the in vivo relevance of these findings...
  71. ncbi A role for caveolin-1 in post-injury reactive neuronal plasticity
    Sophie B Gaudreault
    Douglas Hospital Research Center, Neurological Sciences Department, McGill University, Montreal, Canada
    J Neurochem 92:831-9. 2005
    ..Altogether, these results indicate that caveolin-1 plays an active role in the regulation of injury-induced synaptic and terminal remodeling in the adult CNS...
  72. ncbi Caveolin-1 inhibits neurite growth by blocking Rac1/Cdc42 and p21-activated kinase 1 interactions
    Min Ji Kang
    Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea
    Neuroreport 17:823-7. 2006
    ..From these results, we suggest that the up-regulated caveolin-1 in neuronal cells can inhibit the bFGF signaling pathway from small GTPases to PAK1 by directly binding to PAK1...
  73. pmc Caveolin-1 regulation of dynamin-dependent, raft-mediated endocytosis of cholera toxin-B sub-unit occurs independently of caveolae
    Patrick Lajoie
    Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Cell Mol Med 13:3218-25. 2009
    ..These results suggest that Cav1 regulates raft-dependent internalization of CT-b indirectly via a mechanism that requires the Cav1 scaffolding domain and the formation of oligomerized Cav1 microdomains but not caveolae...
  74. doi Caveolin-1-ablated mice survive in cold by nonshivering thermogenesis despite desensitized adrenergic responsiveness
    Charlotte L Mattsson
    Dept of Physiology, Wenner Gren Institute, Stockholm Univ, Sweden
    Am J Physiol Endocrinol Metab 299:E374-83. 2010
    ....
  75. ncbi Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities
    Babak Razani
    Department of Molecular Pharmacology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:8635-47. 2002
    ..Our initial report on mice lacking caveolin-1 (Cav-1) demonstrated a loss of caveolae and perturbations in endothelial cell function...
  76. ncbi Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue
    Alex W Cohen
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 285:C222-35. 2003
    ..To address this issue, we examined the status of insulin receptor signaling in caveolin-1 (-/-)-deficient (Cav-1 null) mice...
  77. pmc Conformational defects slow Golgi exit, block oligomerization, and reduce raft affinity of caveolin-1 mutant proteins
    Xiaoyan Ren
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, NY 11794 5215, USA
    Mol Biol Cell 15:4556-67. 2004
    ..The conformation of caveolin-1 may be optimized to overcome this difficulty, but remain very sensitive to mutation. Disrupting conformation can coordinately affect oligomerization, raft affinity, and Golgi exit of caveolin-1...
  78. pmc Caveolin-1-deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar Typhimurium infection
    Freddy A Medina
    Department of Cancer Biology, Kimmel Cancer Center, Bluemle Life Sciences Building, Room 933, 233 S 10th Street, Philadelphia, PA 19107, USA
    Infect Immun 74:6665-74. 2006
    ..Here, we sought to determine the role of caveolin-1 (Cav-1) expression in Salmonella pathogenesis...
  79. ncbi Increased Rho activation and PKC-mediated smooth muscle contractility in the absence of caveolin-1
    Yulia Shakirova
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Am J Physiol Cell Physiol 291:C1326-35. 2006
    ..RhoA/Rho-kinase and protein kinase C (PKC)-mediated Ca(2+) sensitization depends on caveolae using caveolin (Cav)-1-deficient (KO) and wild-type (WT) mice...
  80. pmc Immune dysfunction in caveolin-1 null mice following infection with Trypanosoma cruzi (Tulahuen strain)
    Freddy A Medina
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Microbes Infect 9:325-33. 2007
    ..as potentially important targets for pathogenic microorganisms; therefore, we investigated the role of caveolin-1 (Cav-1) in T. cruzi infection using Cav-1 null mice...
  81. ncbi Caveolin regulates endocytosis of the muscle repair protein, dysferlin
    Delia J Hernandez-Deviez
    Institute for Molecular Bioscience, Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 283:6476-88. 2008
    ..In addition, they highlight a novel mechanism of action of caveolins relevant to the pathogenic mechanisms underlying caveolin-associated disease...
  82. pmc Caveolin-1-dependent and -independent membrane domains
    Soazig Le Lay
    Centre de Recherche des Cordeliers, INSERM, U872, Universite Pierre et Marie Curie, Paris 6, France
    J Lipid Res 50:1609-20. 2009
    ..In contrast, the abundance of ordered domains in adherent cells is reduced in Cav1(-/-) compared with WT MEFs, suggesting that cell architecture is critical in maintaining Cav1-induced lipid rafts...
  83. pmc Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway
    Daniela Volonte
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:5462-6. 2009
    ....
  84. pmc Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration
    Rafael Mayoral
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Arturo Duperier 4, 28029 Madrid
    J Biol Chem 285:3633-42. 2010
    Caveolin-1 (Cav-1) is the main structural protein of caveolae and plays an important role in various cellular processes such as vesicular transport, cholesterol homeostasis, and signal transduction pathways...
  85. pmc Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis
    Hong Xia
    Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Am J Pathol 176:2626-37. 2010
    ..This creates a membrane microenvironment depleted of inhibitory phosphatase activity, facilitating the aberrant activation PI3K/Akt and pathological proliferation...
  86. pmc Caveolin-1 protects against sepsis by modulating inflammatory response, alleviating bacterial burden, and suppressing thymocyte apoptosis
    Hong Feng
    Department of Pediatrics, University of Kentucky Medical School, Lexington, Kentucky 40536, USA
    J Biol Chem 285:25154-60. 2010
    ..Caveolin-1 exerts its protective function likely through its roles in modulating inflammatory response, alleviating bacterial burdens, and suppressing thymocyte apoptosis...
  87. pmc Caveolae, fenestrae and transendothelial channels retain PV1 on the surface of endothelial cells
    Eugene Tkachenko
    Department of Medicine, University of California, San Diego, California, United States of America
    PLoS ONE 7:e32655. 2012
    ....
  88. pmc Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin
    Miriam Stoeber
    Institute of Biochemistry, ETH Zurich, Zurich, Switzerland
    EMBO J 31:2350-64. 2012
    ..Thus, EHD2 likely plays a key role in adjusting the balance between PM functions of stationary caveolae and the role of caveolae as vesicular carriers...
  89. pmc Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1
    Michelle M Hill
    The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 7:e43041. 2012
    ..By selectively manipulating PTRF/cavin-1 and caveolin-1 expression (and therefore caveola formation) in multiple cell systems, we unveil caveola-independent functions for both proteins in cell migration...
  90. pmc Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling
    Nicholas Ariotti
    The University of Queensland, Institute for Molecular Bioscience, Queensland 4072, Australia
    J Cell Biol 204:777-92. 2014
    ..Similarly, caveolae transduce mechanical stress into PM lipid alterations that, in turn, modulate Ras PM organization. ..
  91. ncbi Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle
    Z Tang
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 271:2255-61. 1996
    ..Our results also suggest that other as yet unknown caveolin family members are likely to exist and may be expressed in a regulated or tissue-specific fashion...
  92. ncbi Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins
    K S Song
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 271:15160-5. 1996
    ..These results are consistent with previous immunoelectron microscopic studies demonstrating that dystrophin is localized to plasma membrane caveolae in smooth muscle cells...
  93. ncbi Caveolin-1 and caveolin-2 expression in mouse macrophages. High density lipoprotein 3-stimulated secretion and a lack of significant subcellular co-localization
    P Gargalovic
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 276:26164-70. 2001
    ....
  94. ncbi Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities
    B Razani
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, The Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:38121-38. 2001
    ..Recently, we have shown that the human CAV-1 gene is localized to a suspected tumor suppressor locus, and mutations in Cav-1 have been implicated in human ..
  95. ncbi The alpha-isoform of caveolin-1 is a marker of vasculogenesis in early lung development
    Maria I Ramirez
    Pulmonary Center, Departments of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Histochem Cytochem 50:33-42. 2002
    ..Caveolin-1alpha is an early marker for lung vasculogenesis, primarily expressed in developing blood vessels. When the lung is fully differentiated postnatally, caveolin-1alpha is also expressed in alveolar Type I cells...
  96. pmc Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae
    Babak Razani
    Department of Molecular Pharmacology, Institute for Smooth Muscle Biology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 22:2329-44. 2002
    ..We now directly address the functional significance of caveolin-2 by genetically targeting the caveolin-2 locus (Cav-2) in mice...
  97. ncbi Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade
    Scott E Woodman
    Department of Molecular Pharmacology, Division of Hormone Dependent Tumor Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:38988-97. 2002
    ..Caveolin-3 (Cav-3) is the only caveolin family member expressed in striated muscle cell types (cardiac and skeletal)...
  98. ncbi Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice
    William Schubert
    Department of Molecular Pharmacology, the Division of Hormone Dependent Tumor Biology at the Albert Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:40091-8. 2002
    ..Recently, we derived Cav-1 (-/-) knock-out mice using standard homologous recombination techniques...
  99. ncbi Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts
    Alex W Cohen
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Cell Physiol 284:C457-74. 2003
    Recently, development of a caveolin-1-deficient (Cav-1 null) mouse model has allowed the detailed analysis of caveolin-1's function in the context of a whole animal...
  100. pmc Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation
    Franco Capozza
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 162:2029-39. 2003
    ..The human CAV-1 gene is located at a putative tumor suppressor locus (7q31...
  101. ncbi Caveolin-1 null (-/-) mice show dramatic reductions in life span
    David S Park
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biochemistry 42:15124-31. 2003
    ..Caveolin-1 is the principal protein component of caveolae membranes in nonmuscle cells. The recent development of Cav-1-deficient mice has allowed investigators to study the in vivo functional role of caveolae in the context of a ..

Research Grants12

  1. Mechanisms and Effects of Fibronectin Matrix Remodeling
    Jane Sottile; Fiscal Year: 2007
    ....
  2. Influence of Sex and Gender on Musculoskeletal Health
    Barbara Boyan; Fiscal Year: 2004
    ..Worldwide current and future clinical trials will be discussed. Short papers on the workshop topics, future directions, and scientific updates will be published via Internet and summary papers in peer-reviewed journals. ..
  3. Modulation of K channels in renal collecting duct
    Wen Hui Wang; Fiscal Year: 2007
    ....
  4. Pseudomonas invasion and the role of caveolin-2
    David Zaas; Fiscal Year: 2008
    ..A better understanding of these events is required for the eventual development of new adjunctive therapiesand possible prophylactic strategies for high risk patients. ..
  5. ROLE OF MEMBRANES AND MINERALIZATION OF BONES AND TEETH
    Barbara Boyan; Fiscal Year: 2001
    ..This work will have major implications for our understanding of MV and how cells that calcify their matrix are able to regulate these extracellular organelles at distant sites. ..
  6. BONE FACTORS AND ENDOCHONDRAL OSSIFICATION
    Barbara Boyan; Fiscal Year: 2001
    ..It is suggested that these results will provide insight into the role these factors play in bone development and repair. ..
  7. MECHANISMS REGULATING FIBRONECTIN DEPOSITION
    Jane Sottile; Fiscal Year: 2003
    ....
  8. Development of Hydrogel Spinal Disc Replacement
    Barbara Boyan; Fiscal Year: 2004
    ..abstract_text> ..
  9. Invasion of the alveolar epithelium by Pseudomonas
    David Zaas; Fiscal Year: 2004
    ..3) Examine the specific role of caveolin-I in the endocytosis of invasive strains of Pa. ..
  10. Role of a3a4a5(IV) collagen in podocyte behavior
    Corina Borza; Fiscal Year: 2005
    ..abstract_text> ..
  11. Fibronectin in Cell Growth and Vascular Remodeling
    Jane Sottile; Fiscal Year: 2008
    ..These studies will provide important insights into the complex interplay between smooth muscle cells and extracellular matrix, which plays a critical role in the development and progression of vascular disease. [unreadable] [unreadable]..
  12. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010
    ..Finally, these studies could also lead to new approaches to control vasculogenesis and angiogenesis in other clinically important settings, such as anti-angiogenesis treatments designed to fight cancer. ..