Caspr2

Summary

Gene Symbol: Caspr2
Description: contactin associated protein-like 2
Alias: 5430425M22Rik, Caspr2, mKIAA0868, contactin-associated protein-like 2, cell recognition molecule Caspr2
Species: mouse

Top Publications

  1. pmc Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 162:1149-60. 2003
  2. pmc Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers
    Maria Traka
    Department of Basic Science, University of Crete Medical School, Heraklion 71110, Crete, Greece
    J Cell Biol 162:1161-72. 2003
  3. ncbi Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
    S Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 21:7568-75. 2001
  4. pmc Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
    Olga Penagarikano
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 147:235-46. 2011
  5. pmc Translational animal models of autism and neurodevelopmental disorders
    Jacqueline N Crawley
    Robert Chason Chair in Translational Research, M I N D Institute Professor of Psychiatry and Behavioral Sciences, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Dialogues Clin Neurosci 14:293-305. 2012
  6. pmc Immature Neurons and Radial Glia, But Not Astrocytes or Microglia, Are Altered in Adult Cntnap2 and Shank3 Mice, Models of Autism
    Elise C Cope
    Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08540 Department of Psychology, Princeton University, Princeton, New Jersey 08544
    Eneuro 3:. 2016
  7. pmc Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord
    Soha Ashrafi
    Neuroscience Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Neuron 81:120-9. 2014
  8. pmc Caspr and caspr2 are required for both radial and longitudinal organization of myelinated axons
    Aaron Gordon
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 34:14820-6. 2014
  9. pmc Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism
    Olga Penagarikano
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA Center for Autism Research and Treatment and Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Sci Transl Med 7:271ra8. 2015
  10. doi Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes
    Ning Chen
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, Amsterdam 1081 HV, The Netherlands Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, Amsterdam 1081 HV, The Netherlands
    Biochim Biophys Acta 1854:827-33. 2015

Research Grants

Scientific Experts

  • Jacqueline N Crawley
  • Amanda R Rendall
  • David A Buchner
  • Elior Peles
  • Daniel H Geschwind
  • Aaron Gordon
  • Olga Penagarikano
  • Ido Horresh
  • Yasuhiro Ogawa
  • Matthew N Rasband
  • Maria Savvaki
  • Yuko Tanabe
  • PEYMAN GOLSHANI
  • Amos Gdalyahu
  • Domna Karagogeos
  • Vered Bar
  • Brett S Abrahams
  • Kazutada Watanabe
  • Luis de la Torre-Ubieta
  • Julie Palmateer
  • Elise C Cope
  • Samuel S H Wang
  • Ligia A Papale
  • Ning Chen
  • Olga Varea
  • Dongnhu T Truong
  • Daniela Brunner
  • ALEXANDER D KLOTH
  • Sofia Jürgensen
  • Soha Ashrafi
  • Mariko Y Momoi
  • Takashi Momoi
  • Joshua T Trachtenberg
  • Hongmei Dong
  • Jeffrey L Dupree
  • Sebastian Poliak
  • Garret R Anderson
  • Eriko Fujita
  • Rupalatha Maddala
  • Elizabeth D Buttermore
  • Daniela Salomon
  • Peter Fuchs
  • James S Trimmer
  • Fotini Stylianopoulou
  • Annika Lieberoth
  • Antonis Stamatakis
  • Sonja C Vernes
  • Betul Bakkaloglu
  • B S Abrahams
  • Sandra Lacas-Gervais
  • Andrea C Gore
  • Lianna Martin
  • Timothy Schallert
  • Yefim Pen
  • Susana Martinez
  • Maria Traka
  • Arushi Pandya
  • Adam T Brockett
  • Elizabeth Gould
  • Noy Barak
  • Tali Kimchi
  • Pierre Antoine Vigneron
  • Jie Pan
  • Michael Tsoory
  • Jason L Stein
  • Adaora Ofomata
  • Patricia D Hurn
  • Brandy A Briones
  • Maya Opendak
  • Hyejung Won
  • Theresa A Jones
  • Sungita Kumar
  • Alice Luo Clayton
  • Sisi Li
  • Adriana Cherskov
  • Will Spooren
  • Michael Saxe
  • Kailei Chen
  • August B Smit
  • Paul F Worley
  • Vadim Alexandrov
  • Qi Zhang
  • Giorgio Grasselli
  • Peter T Tsai
  • X William Yang
  • Pamela Feliciano
  • Mustafa Sahin
  • Eriko Fujita-Jimbo
  • Hoa A Lam
  • Patricia Kabitzke

Detail Information

Publications40

  1. pmc Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 162:1149-60. 2003
    ..K+ channels are concealed under the myelin sheath in the juxtaparanodal region, where they are associated with Caspr2, a member of the neurexin superfamily...
  2. pmc Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers
    Maria Traka
    Department of Basic Science, University of Crete Medical School, Heraklion 71110, Crete, Greece
    J Cell Biol 162:1161-72. 2003
    ..In the absence of TAG-1, axonal Caspr2 did not accumulate at juxtaparanodes, and the normal enrichment of shaker-type K+ channels in these regions was ..
  3. ncbi Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
    S Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 21:7568-75. 2001
    ..Caspr is present at the paranodal junction formed between the axon and myelinating glial cells, whereas Caspr2 is localized and associates with K(+) channels at the adjacent juxtaparanodal region...
  4. pmc Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
    Olga Penagarikano
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 147:235-46. 2011
    ..These data demonstrate a functional role for CNTNAP2 in brain development and provide a new tool for mechanistic and therapeutic research in ASD...
  5. pmc Translational animal models of autism and neurodevelopmental disorders
    Jacqueline N Crawley
    Robert Chason Chair in Translational Research, M I N D Institute Professor of Psychiatry and Behavioral Sciences, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Dialogues Clin Neurosci 14:293-305. 2012
    ..The field is now poised to employ the most robust phenotypes in the most replicable mouse models for preclinical screening of novel therapeutics...
  6. pmc Immature Neurons and Radial Glia, But Not Astrocytes or Microglia, Are Altered in Adult Cntnap2 and Shank3 Mice, Models of Autism
    Elise C Cope
    Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08540 Department of Psychology, Princeton University, Princeton, New Jersey 08544
    Eneuro 3:. 2016
    ..Future work is needed to explore the functional contribution of adult neurogenesis to autism-related behaviors as well as to temporally characterize glial plasticity as it is associated with ASD...
  7. pmc Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord
    Soha Ashrafi
    Neuroscience Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Neuron 81:120-9. 2014
    ..Our findings define a recognition complex that contributes to the assembly and organization of a specialized GABAergic microcircuit. ..
  8. pmc Caspr and caspr2 are required for both radial and longitudinal organization of myelinated axons
    Aaron Gordon
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 34:14820-6. 2014
    ..The accumulation of Kv1 channels at the juxtaparanodal region depends on the presence of Caspr2 at this site, as well as on the presence of Caspr at the adjacent paranodal junction...
  9. pmc Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism
    Olga Penagarikano
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA Center for Autism Research and Treatment and Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Sci Transl Med 7:271ra8. 2015
    ..These data demonstrate dysregulation of the oxytocin system in Cntnap2 knockout mice and suggest that there may be critical developmental windows for optimal treatment to rectify this deficit. ..
  10. doi Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes
    Ning Chen
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, Amsterdam 1081 HV, The Netherlands Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, Amsterdam 1081 HV, The Netherlands
    Biochim Biophys Acta 1854:827-33. 2015
    ..Contactin-associated protein-like 2 (Caspr2, CNTNAP2) is a known genetic risk factor of autism...
  11. pmc Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons
    Olga Varea
    Departments of Physiology and
    Proc Natl Acad Sci U S A 112:6176-81. 2015
    ..Taken together, our findings provide insight into the biological roles of CNTNAP2 and into the pathogenesis of CNTNAP2-associated neuropsychiatric disorders. ..
  12. pmc The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study
    Amos Gdalyahu
    Department of Neurobiology, Integrative Center for Learning and Memory, Semel Institute for Neuroscience and Behavior, Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States of America
    PLoS ONE 10:e0125633. 2015
    ..Notably, rates of spine elimination were unaltered, suggesting a specific role for CNTNAP2 in stabilizing new synaptic circuitry. ..
  13. doi CASPR2 forms a complex with GPR37 via MUPP1 but not with GPR37(R558Q), an autism spectrum disorder-related mutation
    Yuko Tanabe
    International University of Health and Welfare, Otawara, Tochigi, Japan
    J Neurochem 134:783-93. 2015
    ..Contactin-associated protein-like 2 (CASPR2) is one of the synaptic adhesion molecules associated with ASD...
  14. pmc Cerebellar associative sensory learning defects in five mouse autism models
    ALEXANDER D KLOTH
    Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, United States
    elife 4:e06085. 2015
    ..Our findings indicate that defects in associative temporal binding of sensory events are widespread in autism mouse models. ..
  15. pmc Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder
    Daniela Brunner
    PsychoGenics, Inc, Tarrytown, NY, United States of America Department of Psychiatry, Columbia University, New York, NY, United States of America
    PLoS ONE 10:e0134572. 2015
    ....
  16. pmc Genome-wide disruption of 5-hydroxymethylcytosine in a mouse model of autism
    Ligia A Papale
    Department of Psychiatry
    Hum Mol Genet 24:7121-31. 2015
    ....
  17. doi Auditory processing and morphological anomalies in medial geniculate nucleus of Cntnap2 mutant mice
    Dongnhu T Truong
    Department of Pediatrics, Yale School of Medicine
    Behav Neurosci 129:731-43. 2015
    ....
  18. pmc Selective Dysregulation of Hippocampal Inhibition in the Mouse Lacking Autism Candidate Gene CNTNAP2
    Sofia Jürgensen
    Dominick P Purpura Department of Neuroscience and Rose F Kennedy Intellectual and Developmental Disabilities Research Center, Albert Einstein College of Medicine, Bronx, New York 10461
    J Neurosci 35:14681-7. 2015
    ..Overall, our findings that Cntnap2 deletion selectively impairs perisomatic hippocampal inhibition while sparing excitation provide additional support for synaptic dysfunction as a common mechanism underlying ASDs...
  19. doi Expression of Cntnap2 (Caspr2) in multiple levels of sensory systems
    Aaron Gordon
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Neurosci 70:42-53. 2016
    Genome-wide association studies and copy number variation analyses have linked contactin associated protein 2 (Caspr2, gene name Cntnap2) with autism spectrum disorder (ASD)...
  20. pmc Learning delays in a mouse model of Autism Spectrum Disorder
    Amanda R Rendall
    Department of Psychology Behavioral Neuroscience and Institute for Systems Genomics, University of Connecticut, 406 Babbidge Road, Unit 1020, Storrs, CT 06269, United States Electronic address
    Behav Brain Res 303:201-7. 2016
    ..These findings suggest that CNTNAP2 may influence the development of neural systems important to learning and cross-modal integration, and that disruption of this function could be associated with delayed learning in ASD. ..
  21. doi Ultrasonic vocalization in murine experimental stroke: A mechanistic model of aphasia
    Julie Palmateer
    Departments of Neuroscience, University of Texas at Austin, Austin, TX, USA
    Restor Neurol Neurosci 34:287-95. 2016
    ..Rodents communicate socially with ultrasonic vocalizations (USVs), conveying semantic and semiotic information with complex frequency modulated "songs" and alarm calls...
  22. pmc Advancing the understanding of autism disease mechanisms through genetics
    Luis de la Torre-Ubieta
    Neurogenetics Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Nat Med 22:345-61. 2016
    ..Despite the challenges, these advances provide a solid foundation for the development of rational, targeted molecular therapies. ..
  23. doi Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes
    Maria Savvaki
    Department of Basic Science, University of Crete Medical School, and Institute of Molecular Biology and Biotechnology, Heraklion, Greece
    Mol Cell Neurosci 39:478-90. 2008
    ..TAG-1 is also required for the clustering of Kv1.1/1.2 potassium channels and Caspr2 at the juxtaparanodes of myelinated fibers...
  24. doi Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth
    Annika Lieberoth
    Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
    J Neurosci 29:6677-90. 2009
    ..Their cis interactions with neighboring adhesion molecules, e.g., Caspr1 and Caspr2, and with their triggered signal transduction pathways elicit cell type-specific promotion or inhibition of ..
  25. doi The expression of TAG-1 in glial cells is sufficient for the formation of the juxtaparanodal complex and the phenotypic rescue of tag-1 homozygous mutants in the CNS
    Maria Savvaki
    Department of Basic Science, Faculty of Medicine, University of Crete and Institute of Molecular Biology and Biotechnology Foundation for Research and Technology, 71110, Heraklion, Crete, Greece
    J Neurosci 30:13943-54. 2010
    ..of myelinated fibers as it maintains the integrity of the juxtaparanodal region through its interactions with Caspr2 and the voltage-gated potassium channels (VGKCs) on the axolemma...
  26. pmc The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity
    David A Buchner
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Mamm Genome 23:431-42. 2012
    ..Moreover, as juxtaparanodal proteins have previously been implicated in various neurological disorders, our results suggest a potential genetic and molecular link between obesity and diseases such as autism and epilepsy...
  27. doi Cntnap2 expression in the cerebellum of Foxp2(R552H) mice, with a mutation related to speech-language disorder
    Eriko Fujita
    Center for Medical Science, International University of Health and Welfare, 2600 1, Kitakanemaru, Ohtawara, Tochigi, Japan
    Neurosci Lett 506:277-80. 2012
    ..Taken together, these observations suggest that Foxp2 may regulate ultrasonic vocalization by associating with CtBP in Purkinje cells; Cntnap2 may be a target of this co-repressor...
  28. pmc Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development
    Garret R Anderson
    Department of Molecular and Cellular Physiology, Nancy Pritzker Laboratory, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:18120-5. 2012
    Mutations in the contactin-associated protein 2 (CNTNAP2) gene encoding CASPR2, a neurexin-related cell-adhesion molecule, predispose to autism, but the function of CASPR2 in neural circuit assembly remains largely unknown...
  29. pmc The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons
    Elizabeth D Buttermore
    Department of Cell and Molecular Physiology, University of North Carolina Neuroscience Center, and Carolina Center for Developmental Disabilities, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Neurosci 31:8013-24. 2011
    ..Caspr and Caspr2, which localize at paranodal and juxtaparanodal domains, contain binding sites for the cytoskeletal adaptor ..
  30. pmc Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers
    Rupalatha Maddala
    Department of Ophthalmology, Duke University School of Medicine, NC, USA
    Dev Biol 357:179-90. 2011
    ..Hence, there may be functional parallels between the roles of Prx in membrane stabilization of the myelin sheath and the lens fiber cell...
  31. pmc Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B
    Ido Horresh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 30:2480-9. 2010
    Caspr and Caspr2 regulate the formation of distinct axonal domains around the nodes of Ranvier...
  32. pmc ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:1038-48. 2010
    ..Analysis of Caspr2-, PSD-93-, PSD-95-, and double PSD-93/PSD-95-null mice showed ADAM22 clustering at BCTs requires PSD-95, but ..
  33. pmc Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity
    Peter Fuchs
    Department of Biochemistry and Cell Biology, Max F Perutz Laboratories, University of Vienna, 1030 Vienna, Austria
    J Biol Chem 284:26502-9. 2009
    ..This is the first report demonstrating an important role of plectin in a major nerve function...
  34. pmc Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons
    Ido Horresh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 28:14213-22. 2008
    ..of Kv1 channels at the juxtaparanodal region (JXP) in myelinated axons depends on their association with the Caspr2/TAG-1 adhesion complex...
  35. pmc A functional genetic link between distinct developmental language disorders
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    N Engl J Med 359:2337-45. 2008
    ..Rare mutations affecting the FOXP2 transcription factor cause a monogenic speech and language disorder. We hypothesized that neural pathways downstream of FOXP2 influence more common phenotypes, such as specific language impairment...
  36. pmc Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 28:5731-9. 2008
    ..1, Kv1.2, Kv1.4, and Kvbeta2 subunit-containing K(+) channels, Caspr2, and TAG-1 (transient axonal glycoprotein-1)...
  37. pmc Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders
    Betul Bakkaloglu
    Program on Neurogenetics, Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 82:165-73. 2008
    ....
  38. pmc Genome-wide analyses of human perisylvian cerebral cortical patterning
    B S Abrahams
    Program in Neurogenetics and Neurobehavioral Genetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1769, USA
    Proc Natl Acad Sci U S A 104:17849-54. 2007
    ..Genes identified here provide a foundation for understanding molecular aspects of human-cognitive specializations and the disorders that disrupt them...
  39. ncbi Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton
    Yasuhiro Ogawa
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 26:5230-9. 2006
    ..In contrast, genetic disruption of the juxtaparanodal protein Caspr2 or the nodal cytoskeletal protein betaIV spectrin did not alter the paranodal cytoskeleton...
  40. pmc BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segments
    Sandra Lacas-Gervais
    Medical School, University of Technology Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    J Cell Biol 166:983-90. 2004
    ..These ultrastructural changes can explain the motor and auditory neuropathies present in betaIVSigma1 -/- mice and point to the betaIVSigma1 spectrin isoform as a master-stabilizing factor of AIS/NR membranes...

Research Grants1

  1. Chemical and Genetic Modifiers of the Protein C Pathway
    David Buchner; Fiscal Year: 2007
    ..Successfully rescuing compounds can be quickly tested in human plasma coagulation assays and in vivo mouse models to determine their target and evaluate their therapeutic potential. ..