Casp8

Summary

Gene Symbol: Casp8
Description: caspase 8
Alias: CASP-8, FLICE, MACH, Mch5, caspase-8, Fas-linked ICE-like protease
Species: mouse

Top Publications

  1. pmc Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis
    Meng Zhang
    Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Free Radic Biol Med 50:1252-62. 2011
  2. ncbi Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease
    V Viswanath
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 21:9519-28. 2001
  3. doi Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages
    Tatsukuni Ohno
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Immunol 183:7890-7. 2009
  4. pmc Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes
    D V Delfino
    Section of Pharmacology Toxicology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Cell Death Differ 18:183-90. 2011
  5. ncbi Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy
    J Brayer
    Department of Oral Biology, University of Florida, Gainesville 32610, USA
    J Rheumatol 27:1896-904. 2000
  6. ncbi Murine coronavirus-induced apoptosis in 17Cl-1 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and bid cleavage
    Chun Jen Chen
    Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, 77555 1019, USA
    Virology 302:321-32. 2002
  7. pmc Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
    Mangatt P Biju
    Department of Medicine, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 6144, USA
    Mol Cell Biol 24:9038-47. 2004
  8. ncbi Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
    E E Varfolomeev
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Immunity 9:267-76. 1998
  9. ncbi Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart
    K Sakamaki
    Graduate School of Biostudies and Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Cell Death Differ 9:1196-206. 2002
  10. pmc Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity
    Leonardo Salmena
    The Advanced Medical Discovery Institute AMDI, Ontario Cancer Institute, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1, Canada
    Genes Dev 17:883-95. 2003

Research Grants

  1. DIAPHRAGMATIC DYSFUNCTION IN SEPSIS
    GERALD SUPINSKI; Fiscal Year: 2001
  2. FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILURE
    GERALD SUPINSKI; Fiscal Year: 2005
  3. Caspase Mediated Diaphragmatic Dysfunction
    GERALD SUPINSKI; Fiscal Year: 2009
  4. MAPK/PKR Modulation of Diaphragm Weakness
    Gerald S Supinski; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications124 found, 100 shown here

  1. pmc Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis
    Meng Zhang
    Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Free Radic Biol Med 50:1252-62. 2011
    Fas-mediated apoptosis is a crucial cellular event. Fas, the Fas-associated death domain, and caspase 8 form the death-inducing signaling complex (DISC). Activated caspase 8 mediates the extrinsic pathways and cleaves cytosolic BID...
  2. ncbi Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease
    V Viswanath
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 21:9519-28. 2001
    ..These data suggest that caspase inhibitors constitute a plausible therapeutic for PD...
  3. doi Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages
    Tatsukuni Ohno
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Immunol 183:7890-7. 2009
    ..These observations suggest that caspase-1-, caspase-8-, and calpain-independent IL-33 production by macrophages and/or mast cells may contribute to the pathogenesis of Th2-type allergic inflammation...
  4. pmc Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes
    D V Delfino
    Section of Pharmacology Toxicology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Cell Death Differ 18:183-90. 2011
    ..In summary, our results suggest that caspase-8 activation protects Gilz from proteasomal degradation and induces its binding to SUMO-1 in GC-treated thymocytes...
  5. ncbi Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy
    J Brayer
    Department of Oral Biology, University of Florida, Gainesville 32610, USA
    J Rheumatol 27:1896-904. 2000
    ..We investigated if these 2 autoimmune diseases share a genetic predisposition...
  6. ncbi Murine coronavirus-induced apoptosis in 17Cl-1 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and bid cleavage
    Chun Jen Chen
    Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, 77555 1019, USA
    Virology 302:321-32. 2002
    ..All our data indicate that a mitochondria-mediated pathway played a major regulatory role in apoptosis in MHV-infected 17Cl-1 cells...
  7. pmc Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
    Mangatt P Biju
    Department of Medicine, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 6144, USA
    Mol Cell Biol 24:9038-47. 2004
    ..Increased apoptosis was a result of enhanced caspase 8 activity, while Bcl-2 and Bcl-XL transgene expression had little effect on this phenotype...
  8. ncbi Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
    E E Varfolomeev
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Immunity 9:267-76. 1998
    Homozygous targeted disruption of the mouse Caspase 8 (Casp8) gene was found to be lethal in utero. The Caspase 8 null embryos exhibited impaired heart muscle development and congested accumulation of erythrocytes...
  9. ncbi Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart
    K Sakamaki
    Graduate School of Biostudies and Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Cell Death Differ 9:1196-206. 2002
    ..5-E11.5, suggesting that these defects are most likely secondary to a lack of physiological caspase-8 activity. Taken together, these results suggest that caspase-8 is indispensable for embryonic development...
  10. pmc Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity
    Leonardo Salmena
    The Advanced Medical Discovery Institute AMDI, Ontario Cancer Institute, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1, Canada
    Genes Dev 17:883-95. 2003
    ..The in vivo role of caspase 8, a component of this pathway, has eluded analysis in postnatal tissues because of the lack of an appropriate ..
  11. ncbi Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    Li Yu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 304:1500-2. 2004
    ..Clinical therapies involving caspase inhibitors may arrest apoptosis but also have the unanticipated effect of promoting autophagic cell death...
  12. ncbi Caspase-8 serves both apoptotic and nonapoptotic roles
    Tae Bong Kang
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 173:2976-84. 2004
    ..Thus, besides participating in cell death induction by receptors of the TNF/nerve growth factor family, caspase-8, apparently independently of these receptors, also mediates nonapoptotic and perhaps even antiapoptotic activities...
  13. ncbi Requirement for caspase-8 in NF-kappaB activation by antigen receptor
    Helen Su
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 307:1465-8. 2005
    ..These findings thus explain the paradoxical association of defective apoptosis and combined immunodeficiency in human CED...
  14. ncbi Cutting edge: innate immunity conferred by B cells is regulated by caspase-8
    Daniel R Beisner
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 175:3469-73. 2005
    ..To determine whether caspase-8 is also required for B cell proliferation, we generated mice with a B cell-specific Casp8 deficiency. Unlike T cells, caspase-8 was not required for Ag receptor-driven proliferation or Ab formation...
  15. pmc Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder
    Leonardo Salmena
    Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1, Canada
    J Exp Med 202:727-32. 2005
    ..Peripheral casp8-/- T cells manifest activation marker up-regulation and are proliferating in the absence of any infection or ..
  16. ncbi In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis
    Shine Tu
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Nat Cell Biol 8:72-7. 2006
    ..This approach unambiguously identifies the apical caspase activated in response to apoptotic stimuli, and establishes caspase-2 as a proximal mediator of heat shock-induced apoptosis...
  17. ncbi Potentiation of neuroblastoma metastasis by loss of caspase-8
    Dwayne G Stupack
    Department of Pathology and The John and Rebecca Moores Cancer Center, The University of California at San Diego, La Jolla, California 92093 0803, USA
    Nature 439:95-9. 2006
    ..These findings define caspase-8 as a metastasis suppressor gene that, together with integrins, regulates the survival and invasive capacity of neuroblastoma cells...
  18. ncbi Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling
    Benedicte Lemmers
    Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 2C1, Canada
    J Biol Chem 282:7416-23. 2007
    ..Our study supports dual roles for caspase-8 in apoptotic and nonapoptotic functions and demonstrates its requirement for TLR signaling and in the regulation of NFkappaB function...
  19. ncbi Role of caspase-8 in hepatocyte response to infection and injury in mice
    Tehila Ben Moshe
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Hepatology 45:1014-24. 2007
    ....
  20. ncbi A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2
    Adrian F Arechiga
    Department of Molecular Biology and Biochemistry, Center for Immunology, University of California, Irvine, CA 92697, USA
    J Immunol 179:5291-300. 2007
    ..These results demonstrate that a FADD/caspase-8-signaling axis promotes T cell cycle progression and sustained S6K activity...
  21. doi Cell-autonomous and non-cell-autonomous functions of caspase-8
    Tehila Ben Moshe
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Cytokine Growth Factor Rev 19:209-17. 2008
    ....
  22. ncbi Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice
    Tae Bong Kang
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 181:2522-32. 2008
    ....
  23. pmc FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells
    Bryan D Bell
    Department of Molecular Biology and Biochemistry and Center for Immunology, University of California, Irvine, Irvine, CA 92697 3900, USA
    Proc Natl Acad Sci U S A 105:16677-82. 2008
    Fas-associated death domain protein (FADD) and caspase-8 (casp8) are vital intermediaries in apoptotic signaling induced by tumor necrosis factor family ligands...
  24. pmc Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim
    Thomas Kaufmann
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia
    Immunity 30:56-66. 2009
    ..These observations identify caspase-8 and the BH3-only proteins Bid and Bim as potential therapeutic targets for treatment of inflammatory liver diseases...
  25. doi Caspase-8 is involved in neovascularization-promoting progenitor cell functions
    Dörte Scharner
    Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 29:571-8. 2009
    ..Caspases mediate apoptosis but are also involved in other critical biological processes. Therefore, we aimed to address the role of caspases in proangiogenic cells...
  26. pmc Caspase-8: a key role in the pathogenesis of diabetic embryopathy
    Zhiyong Zhao
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Birth Defects Res B Dev Reprod Toxicol 86:72-7. 2009
    ..These data suggest that caspase-8 may control diabetic embryopathy-associated apoptosis via regulation of the Bid-stimulated mitochondrion/caspase-9 pathway...
  27. pmc Dynamic expression of epidermal caspase 8 simulates a wound healing response
    Pedro Lee
    Section of Cell and Developmental Biology, Division of Biological Sciences, Natural Science Building, Room 6311, 9500 Gilman Drive, MC 0380, La Jolla, California 92093, USA
    Nature 458:519-23. 2009
    ..Here we demonstrate that the loss of epidermal caspase 8, an important mediator of apoptosis, recapitulates several phases of a wound healing response in the mouse...
  28. pmc Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease
    Andrew Kovalenko
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Exp Med 206:2161-77. 2009
    ....
  29. pmc The death effector domains of caspase-8 induce terminal differentiation
    Ainhoa Mielgo
    Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA
    PLoS ONE 4:e7879. 2009
    ..The results demonstrate a new function for the DEDs of caspase-8, and describe an unexpected mechanism that contributes to cell differentiation and senescence...
  30. ncbi Inhibitory effects of short hairpin RNA against caspase-8 on apoptosis of murine hepatoma Hepa1-6 cells
    Sen Lin
    Department of Rheumatism and Immune Disease, Shandong Provincial Hospital, Ji Nan, Shandong, China
    Biosci Trends 3:53-7. 2009
    ..05). This study suggested that shRNAs against caspase-8 could effectively inhibit apoptosis of Hepa1-6 cells induced by TNF-alpha by suppressing caspase-8 mRNA expression...
  31. pmc In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8
    Ian E Gentle
    Department of Biochemistry and La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia
    J Biol Chem 286:13282-91. 2011
    ..This resulted in processing of p100 NF-κB2 to p52, a decrease in levels of cFLIP(L), and activation of caspase-8, culminating in cell death. Therefore, the pro-survival effect of RIPK1 is mediated by stabilization of TRAF2 and cIAP1...
  32. pmc RIP3 mediates the embryonic lethality of caspase-8-deficient mice
    William J Kaiser
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 471:368-72. 2011
    ..complementary pathways controlled by common signalling adaptors, kinases and proteases; among these, caspase-8 (Casp8) is critical for death receptor-induced apoptosis...
  33. pmc Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
    Andrew Oberst
    Dept of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 471:363-7. 2011
    ..RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with FLICE-like inhibitory protein long (FLIP(L), also known as CFLAR), and this complex is required for the protective ..
  34. pmc Mechanisms of necroptosis in T cells
    Irene L Ch'en
    Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 208:633-41. 2011
    ..parallel, nonapoptotic pathway of cell death, has been described, and this pathway is invoked in the absence of caspase 8. In caspase 8-deficient T cells, necroptosis occurs as the result of antigen receptor-mediated activation...
  35. doi Loss of caspase-8 protects mice against inflammation-related hepatocarcinogenesis but induces non-apoptotic liver injury
    Christian Liedtke
    Department of Medicine III, University Hospital, Aachen, Germany
    Gastroenterology 141:2176-87. 2011
    ..Activation of caspase-8 (Casp8) initiates death receptor-mediated apoptosis...
  36. pmc Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis
    Claudia Günther
    Department of Medicine 1, Friedrich Alexander University, D 91054 Erlangen, Germany
    Nature 477:335-9. 2011
    ..Mice with a conditional deletion of caspase-8 in the intestinal epithelium (Casp8(ΔIEC)) spontaneously developed inflammatory lesions in the terminal ileum and were highly susceptible to colitis...
  37. pmc Caspase 8 inhibits programmed necrosis by processing CYLD
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Cell Biol 13:1437-42. 2011
    b>Caspase 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and processing the executioner caspase 3 (ref. 1)...
  38. doi Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents
    Maximilian Hatting
    Department of Internal Medicine III, University Hospital, RWTH Aachen, Germany
    Hepatology 57:2189-201. 2013
    ..b>Caspase 8 (Casp8) is essential for death-receptor-mediated apoptosis activity and therefore its modulation might be ..
  39. doi Caspase 8 differentially controls hepatocytes and non-parenchymal liver cells during chronic cholestatic liver injury in mice
    Kunal Chaudhary
    Department of Medicine III, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Hepatol 59:1292-8. 2013
    ..Here we investigated how caspase 8 (Casp8) differentially regulates immune-mediated liver injury and regeneration in distinct liver cell types ..
  40. doi RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation
    Mihael Vucur
    Department of Medicine III, University Hospital RWTH Aachen, D 52074 Aachen, Germany
    Cell Rep 4:776-90. 2013
    ..These findings demonstrate a function of RIP3 in regulating carcinogenesis and cholestasis. Controlling RIP3 or Caspase-8 might represent a chemopreventive or therapeutic strategy against hepatocellular carcinoma and biliary disease. ..
  41. pmc Protective roles for caspase-8 and cFLIP in adult homeostasis
    Ricardo Weinlich
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Rep 5:340-8. 2013
    Caspase-8 or cellular FLICE-like inhibitor protein (cFLIP) deficiency leads to embryonic lethality in mice due to defects in endothelial tissues...
  42. ncbi Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase signaling and caspase 8 activation
    Asima Bhattacharyya
    Department of Chemistry, Bose Institute, 93 1 Acharya Prafulla, Chandra Road, Kolkata 700 009, India
    J Biol Chem 278:26517-25. 2003
    ..avium. ASK1/p38 MAP kinase signaling was linked to the activation of caspase 8. At the same time, M...
  43. ncbi Caspase knockouts: matters of life and death
    T S Zheng
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cell Death Differ 6:1043-53. 1999
    ..We will also provide our prediction on the direction of future studies in this ever-growing field of caspases...
  44. ncbi In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons
    Masanori Tomioka
    Laboratory for Proteolytic Neuroscience, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Brain Res Mol Brain Res 108:18-32. 2002
    ..These results indicate that p35-inhibitable caspases play rather minor roles in the kainate-induced excitotoxicity and that the relative contribution of calpain is likely to be greater than that of caspases...
  45. ncbi Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70
    Yasuhiko Matsumori
    Department of Neurological Surgery, University of California, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Stroke 37:507-12. 2006
    ....
  46. pmc Regulation of apoptosis by XIAP ubiquitin-ligase activity
    Andrew J Schile
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Genes Dev 22:2256-66. 2008
    ..This demonstrates a physiological requirement of XIAP ubiquitin-ligase activity for the inhibition of caspases and for tumor suppression in vivo...
  47. pmc Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1
    Hua Li
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 71:3625-34. 2011
    ..Induction of autophagy required Beclin 1 and was associated with blockage of Beclin 1 cleavage by caspase 8 at two sites...
  48. pmc Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes
    Ji An Pan
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794 5222, USA
    Mol Cell Biol 31:3158-70. 2011
    ..Our results unveiled a previously unknown mechanism through which disruption of protein homeostasis induces caspase-8 oligomerization, activation, and apoptosis...
  49. pmc Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis
    Krishna M Irrinki
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA
    Mol Cell Biol 31:3745-58. 2011
    ..Finally, elimination of BAX and BAK or overexpression of Bcl-x(L) protects cells from necroptosis at a later step. These findings provide evidence that mitochondria play an amplifying role in inflammation-induced necroptosis...
  50. pmc Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival
    Jiro Takano
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Mol Cell Biol 31:4097-106. 2011
    ..Triple-knockout mice exhibited early embryonic lethality, a finding consistent with the notion that this protease system is vital for embryonic survival...
  51. pmc AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages
    R Pierini
    Universite de Lyon, France
    Cell Death Differ 19:1709-21. 2012
    ..This work underscores the crosstalk between inflammasome components and the apoptotic machinery and highlights the versatility of the pathway, which can switch from pyroptosis to apoptosis...
  52. pmc Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy
    Xuezheng Li
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes 61:2084-92. 2012
    ..Our results show that JNK1 and JNK2 are equally involved in diabetic embryopathy and that the oxidative stress-JNK1/2-caspase pathway mediates the proapoptotic signals and the teratogenicity of maternal diabetes...
  53. pmc Induction of Fas mediated caspase-8 independent apoptosis in immune cells by Armigeres subalbatus saliva
    Shanshan Liu
    Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, Shantou, People s Republic of China
    PLoS ONE 7:e41145. 2012
    ..Armigeres subalbatus is one of the prominent types of mosquitoes involved in the transmission of parasitic and viral diseases in humans and animals...
  54. doi Loss of caspase-8 in hepatocytes accelerates the onset of liver regeneration in mice through premature nuclear factor kappa B activation
    Julia Freimuth
    Department of Medicine III, University Hospital Aachen, Aachen, Germany
    Hepatology 58:1779-89. 2013
    ..different pathways leading to nuclear factor kappa B (NF-κB) activation, apoptosis signaling by way of caspase-8 (Casp8), and activation of cJun N-terminal kinases (JNK)...
  55. pmc FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes
    Prajwal Gurung
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105
    J Immunol 192:1835-46. 2014
    ..Thus, our results reveal FADD and caspase-8 as apical mediators of canonical and noncanonical Nlrp3 inflammasome priming and activation. ..
  56. pmc RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
    William J Kaiser
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 111:7753-8. 2014
    ..RIPK1) mediates programmed necrosis and, together with its partner, RIP3 (RIPK3), drives midgestational death of caspase 8 (Casp8)-deficient embryos...
  57. pmc Dietary modulation of the microbiome affects autoinflammatory disease
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 516:246-9. 2014
    ..Collectively, this work reveals diet-associated changes in the intestinal microbiome as a crucial factor regulating inflammasome- and caspase-8-mediated maturation of IL-1β and osteomyelitis in Pstpip2(cmo) mice...
  58. pmc Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
    Christina Antonopoulos
    Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
    J Biol Chem 290:20167-84. 2015
    ..nigericin-stimulated caspase-1 activation and activity are only modestly attenuated in caspase-8-deficient (Casp8(-/-)Rip3(-/-)) BMDC, these cells do not exhibit the rapid loss of viability of WT cells...
  59. pmc IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells
    Chi Keung Wan
    Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 7B05, Bethesda, Maryland 20892 1674 USA
    Nat Commun 6:7988. 2015
    ..These results demonstrate lineage-restricted IL-21-induced IL-1β via a non-canonical pathway and provide evidence for its importance in vivo. ..
  60. pmc Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
    Edel Kavanagh
    Department of Oncology Pathology, Cancer Centrum Karolinska, R8 03, Karolinska Institutet, 171 76 Stockholm, Sweden
    Aging (Albany NY) 7:673-89. 2015
    ..In neither of these models, CASP8 deletion appeared to affect the overall number of microglia expressing the pan specific microglia marker, Iba1...
  61. doi Inhibition of caspase-8 activity caused by overexpression of BCL10 contributes to the pathogenesis of high-grade MALT lymphoma
    Yan Chen
    Department of Immunology, Capital Medical University, Beijing, China
    Pediatr Blood Cancer 58:865-71. 2012
    ..To explore the molecular mechanism of BCL10 overexpression on the pathogenesis and malignant phenotype of MALT lymphoma, we generated EµSR-BCL10 transgenic mice...
  62. doi Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis
    Anne Hakem
    Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Blood 119:3495-502. 2012
    ..We also report that deficiency of caspase-8 results in impaired cytokinesis and that casp8(-/-) lymphomas display remarkably elevated levels of chromosomal aberrations...
  63. pmc Survival function of the FADD-CASPASE-8-cFLIP(L) complex
    Christopher P Dillon
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Rep 1:401-7. 2012
    ....
  64. pmc Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis
    Ji An Pan
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794, USA
    J Biol Chem 288:2952-63. 2013
    ..Our results uncover a new mechanism of caspase-8-mediated apoptosis induced by intracellular calcium overload that is dependent on the autophagy-related proteins LC3 and p62 upon hyperactivation of DEG/ENaC channels...
  65. pmc Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation
    M Amir
    Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Death Differ 20:878-87. 2013
    ..Autophagy, therefore, mediates cellular resistance to TNF toxicity in vivo by blocking activation of caspase-8 and the mitochondrial death pathway, suggesting that autophagy is a therapeutic target in TNF-dependent tissue injury...
  66. ncbi Assignment of CASP8 to human chromosome band 2q33-->q34 and Casp8 to the murine syntenic region on chromosome 1B-proximal C by in situ hybridization
    F C Kischkel
    Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    Cytogenet Cell Genet 82:95-6. 1998
  67. ncbi Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus
    T Furuyashiki
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8315, Japan
    J Neurosci 19:109-18. 1999
    ..Thus, Citron-PSD-95/SAP-90 interaction may provide a region- and cell type-specific link between the Rho signaling cascade and the synaptic NMDA receptor complex...
  68. ncbi The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice
    M Los
    Department of Internal Medicine I, Medical Clinics, University of Tubingen, Germany
    Immunity 10:629-39. 1999
  69. ncbi The modular nature of apoptotic signaling proteins
    K Hofmann
    MEMOREC Stoffel GmbH, Koln, Germany
    Cell Mol Life Sci 55:1113-28. 1999
    ....
  70. ncbi Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies
    J Wang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N311, MSC 1892, Bethesda, MD 20892 18892, USA
    J Cell Sci 113:753-7. 2000
    ..These studies suggest that caspases function in cell signaling events including apoptosis, cell growth and differentiation...
  71. ncbi Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis
    S B Bratton
    MRC Toxicology Unit, Hodgkin Building, University of Leicester, Lancaster Road, Leicester, LE1 9HN, United Kingdom
    Exp Cell Res 256:27-33. 2000
    ..Caspases-8 and -9 appear to be the apical caspases activated in death receptor- and mitochondrial stress-induced apoptosis, respectively. The role of large protein complexes in mediating these pathways is discussed...
  72. ncbi Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation
    Maria Cristina Marchetti
    Department of Clinical and Experimental Medicine, Pharmacology Section, University of Perugia, University of L Aquila, Italy
    Blood 101:585-93. 2003
    ..Caspase-8 activation is countered by the inhibition of macromolecular synthesis and of Src kinase, PI-PLC, and aSMase activation, suggesting it is downstream in the DEX-activated apoptotic pathway of thymocytes...
  73. ncbi Perforin-dependent activation-induced cell death acts through caspase 3 but not through caspases 8 or 9
    Liane Chen
    Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Eur J Immunol 33:769-78. 2003
    ..Blocking anti-Fas ligand antibody failed to inhibit death, and no processing of either caspase 8 or caspase 9 was detected in recrosslinked cells...
  74. ncbi Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway
    Xue Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 278:29184-91. 2003
    ..We have, for the first time, identified a predominant role for the caspase-8/Bid pathway in signaling associated with hyperoxic lung injury and cell death in vivo and in vitro...
  75. ncbi Lipopolysaccharides indirectly stimulate apoptosis and global induction of apoptotic genes in fibroblasts
    Mani Alikhani
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:52901-8. 2003
    ..Thus, LPS acts to modulate the expression of a large number of genes that favor apoptosis of fibroblastic cells that is dependent upon activation of caspase-8 and is largely mediated by TNF...
  76. ncbi Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons
    Won Seok Choi
    Department of Biology and Protein Network Research Center, Yonsei University College of Science, 134 Shinchon dong, Seodaemoon Gu, Seoul 120 749, Korea
    J Biol Chem 279:20451-60. 2004
    ....
  77. pmc Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation
    Raid Kassis
    Laboratoire de la Rage, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Virol 78:6543-55. 2004
    ..In our model, Fas ligand (CD95L) appears to play a limited role in lyssavirus-mediated neuroblastoma cell death. Similarly, tumor necrosis factor alpha does not appear to play an important role...
  78. ncbi Analysis of caspase-3, caspase-8 and caspase-9 enzymatic activities in mouse oocytes and zygotes
    Adrian Papandile
    Biology Department, Northeastern University, Boston, Massachusetts 02115, USA
    Zygote 12:57-64. 2004
    ....
  79. ncbi Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells
    Sumit Shah
    School of Pharmacy, 700 University Avenue, University of Louisiana at Monroe, Monroe, Louisiana 71209 0470, USA
    Exp Biol Med (Maywood) 229:745-55. 2004
    ..phospho-Akt (active), and phospho-glycogen synthase kinase3, as well as decreasing intracellular levels of FLICE-inhibitory protein (FLIP), an antiapoptotic protein that inhibits caspase-8 activation, in these cells...
  80. ncbi Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions
    Young Jae Nam
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Cell 15:901-12. 2004
    ..Conversely, physiological levels of ARC suppress these events. These studies establish a critical role for nonhomotypic death-fold interactions in the regulation of apoptosis...
  81. ncbi Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection
    Elisabeth M Silva
    Instituto de Biofisica Carlos Chagas Filho, Centro de Ciencias da Saude, Bloco G, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Immunol 174:6314-21. 2005
    ..These results suggest a critical role for caspase-8 in the establishment of T cell memory, cell signaling, and regulation of cytokine responses during protozoan infection...
  82. ncbi Axonal dynactin p150Glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis
    Christine Carson
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Neurosci 25:6092-104. 2005
    ....
  83. ncbi Apoptosis through targeted activation of caspase 8 ("ATTAC-mice"): novel mouse models of inducible and reversible tissue ablation
    Maria E Trujillo
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 4:1141-5. 2005
    ..The FAT-ATTAC mouse is a transgenic model whereby expression of a myristoylated caspase 8-FKBP fusion protein enables selective ablation of adipocytes via induction of apoptosis that occurs upon ..
  84. ncbi c-Flip expression and function in fetal mouse gonocytes
    Claudia Giampietri
    Istituto Pasteur Fondazione Cenci Bolognetti, Department of Histology and Medical Embryology, University of Rome La Sapienza, Rome, Italy
    FASEB J 20:124-6. 2006
    ..These data represent the first evidence demonstrating c-Flip expression in fetal testes and its role in protecting gonocytes from Fas-dependent apoptosis...
  85. ncbi TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB
    Liusheng He
    Flow Cytometry Section, Office of Science and Technology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:11235-49. 2006
    ..The mechanism of apoptosis induction results from the capacity of human TRAF6 to interact and activate caspase 8. Both the C-terminal TRAF domain of human TRAF6, which directly interacts with the death effector domain of pro-..
  86. ncbi The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
    Lufen Chang
    Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 E Duarte Road, KCRB 3009, Duarte, CA 91010, USA
    Cell 124:601-13. 2006
    ..Thus, JNK antagonizes NF-kappaB during TNFalpha signaling by promoting the proteasomal elimination of c-FLIP(L)...
  87. ncbi Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress
    Ruying Chang
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Biochem 100:267-78. 2007
    ..Thus, our results suggest that eEF1A-2 interacts with Prdx-I to functionally provide cells with extraordinary resistance to oxidative stress-induced cell death...
  88. ncbi Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Nature 445:177-82. 2007
    ....
  89. pmc BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms
    Arnaud A Mailleux
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 12:221-34. 2007
    ..These data provide important mechanistic information on the processes involved in sculpting the mammary gland and demonstrate that BIM is a critical regulator of apoptosis in vivo...
  90. ncbi Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells
    Sabine Gröbner
    Institute of Medical Microbiology and Hygiene, University of Tubingen, Elfriede Aulhorn Str, 6, 72076, Tuebingen, Germany
    Apoptosis 12:1813-25. 2007
    ..Altogether our findings indicate that Yersinia-induced DC death is independent of death domain containing receptors, but mediated by RIP and caspase-8 at the level of DISC...
  91. ncbi TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia
    Seija Lehnardt
    Center for Anatomy, Institute of Cell Biology and Neurobiology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Immunol 179:6134-43. 2007
    ..We suggest that TLR2- and caspase-8-mediated microglial apoptosis constitutes an autoregulatory mechanism that limits GBS-induced overactivation of the innate immune system in the CNS...
  92. pmc TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis
    Honghong Sun
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell 133:415-26. 2008
    ..These results establish that TIPE2 is an essential negative regulator of TLR and TCR function, and its selective expression in the immune system prevents hyperresponsiveness and maintains immune homeostasis...
  93. doi Caspase-8 deficiency facilitates cellular transformation in vitro
    Y Krelin
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Cell Death Differ 15:1350-5. 2008
    ....
  94. doi p63 regulates the caspase-8-FLIP apoptotic pathway in epidermis
    S Borrelli
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, Milano 20133, Italy
    Cell Death Differ 16:253-63. 2009
    ..Therefore, p63 fine-tunes the Procaspase-8-FLIP pro- and antiapoptotic pathway in keratinocytes...
  95. pmc Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways
    Dandan Jin
    School of Life Sciences, Department of Medical Microbiology and Parasitology, School of Medicine, Zhejiang University, 388 Yu Hang Tang Road, Hangzhou 310058, China
    Infect Immun 77:799-809. 2009
    ..These data indicate that L. interrogans-induced apoptosis in macrophages is mediated by caspase-3 and -6 activation through a FADD-caspase-8-dependent pathway, independently of mitochondrial cytochrome c-caspase-9-dependent signaling...
  96. doi Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway
    S Inoue
    MRC Toxicology Unit, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester LE1 9HN, UK
    Cell Death Differ 16:1053-61. 2009
    ..The processing of caspase-2 and -6 occurs within the cytoplasm and active caspase-6 is then responsible for both the processing of caspase-8 and the cleavage of caspase-6 substrates, including lamin A/C...
  97. doi TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism
    Xiaoyan Wu
    Section of Nephrology, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Renal Physiol 297:F316-26. 2009
    ..These cell culture experiments support a role for caspase activation in TNF-induced inflammation in the renal endothelium, a key event in LPS-induced AKI...
  98. doi Life-giving caspases: revealing new roles during mouse embryo preimplantation development
    Dolores Busso
    Department of Physiology, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Int J Dev Biol 54:857-65. 2010
    ..The use of specific caspase inhibitors during in vitro embryo culture showed that caspase 8 activity, but not caspase 2 or 9, was relevant for development...
  99. doi RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein
    Akhil Rajput
    Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Immunity 34:340-51. 2011
    ..The dependence of RIP1 cleavage on the same molecular change as that facilitating RIG-I signaling allows for RIG-I signaling to be restricted in its duration without compromising its initial activation...
  100. pmc Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury
    Erica Ullman
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794 5222, USA
    Mol Cell Biol 31:2902-19. 2011
    ..Hence, on one hand, SCCA1 inhibits cell death induced by lysosomal injury while, on the other hand, it sensitizes cells to ER stress by activating caspase-8 independently of the death receptor apoptotic pathway...
  101. ncbi Molecular cloning and characterization of mouse caspase-8
    K Sakamaki
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Japan
    Eur J Biochem 253:399-405. 1998
    ..Among these caspases, human caspase-8 (FLICE/MACH/Mch5) has been isolated and shown to be indispensable for Fas-mediated apoptotic signaling...

Research Grants4

  1. DIAPHRAGMATIC DYSFUNCTION IN SEPSIS
    GERALD SUPINSKI; Fiscal Year: 2001
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of sepsis-induced muscle dysfunction. ..
  2. FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILURE
    GERALD SUPINSKI; Fiscal Year: 2005
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of heart failure-related skeletal muscle dysfunction. ..
  3. Caspase Mediated Diaphragmatic Dysfunction
    GERALD SUPINSKI; Fiscal Year: 2009
    ..These experiments will use both transgenic animal models and C2C12 cells to assess the effect of genetic and chemical inhibition of superoxide/nitric oxide on caspase responses. ..
  4. MAPK/PKR Modulation of Diaphragm Weakness
    Gerald S Supinski; Fiscal Year: 2010
    ..and PKR kinase pathways interact to regulate diaphragm muscle death receptor activation, death receptor active caspase 8 formation, and caspase mediated reductions in diaphragm force generation...