Casp4

Summary

Gene Symbol: Casp4
Description: caspase 4, apoptosis-related cysteine peptidase
Alias: CASP-11, CASP-4, Casp11, Caspl, ich-3, caspase-4, caspase 11, apoptosis-related cysteine peptidase, caspase 11, apoptosis-related cysteine protease, caspase 4, apoptosis-related cysteine protease, caspase-11 short form splicing, protease ICH-3
Species: mouse

Top Publications

  1. ncbi Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE
    S Wang
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 271:20580-7. 1996
  2. pmc Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis
    D Demon
    1 Department of Medical Protein Research, VIB, Ghent, Belgium 2 Department of Biochemistry, Ghent University, Ghent, Belgium
    Mucosal Immunol 7:1480-91. 2014
  3. pmc Caspase-11 activation in response to bacterial secretion systems that access the host cytosol
    Cierra N Casson
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 9:e1003400. 2013
  4. ncbi Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response
    S J Kang
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Cell Death Differ 9:1115-25. 2002
  5. ncbi Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1
    Reinout Schauvliege
    Department of Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    J Biol Chem 277:41624-30. 2002
  6. ncbi Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization
    Juying Li
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Nat Cell Biol 9:276-86. 2007
  7. pmc Caspase-11 protects against bacteria that escape the vacuole
    Youssef Aachoui
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Science 339:975-8. 2013
  8. pmc Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination
    S Hisahara
    Division of Neuroanatomy, Department of Neuroscience, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Exp Med 193:111-22. 2001
  9. pmc Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity
    Juying Li
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 181:321-33. 2008
  10. pmc Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila
    Christopher L Case
    Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 110:1851-6. 2013

Scientific Experts

  • Leigh A Knodler
  • Tessa Bergsbaken
  • Nobuhiko Kayagaki
  • Sharad Kumar
  • M Lenardo
  • Kyoungho Suk
  • T S Zheng
  • K A Roth
  • Shin Jung Kang
  • Masahiro Yamamoto
  • Etienne Meunier
  • Petr Broz
  • Juying Li
  • Vijay A K Rathinam
  • Martina Kovarova
  • Pamela R Hesker
  • Tsuyoshi Furuya
  • George M H Birchenough
  • Ivan Zanoni
  • S Wang
  • Christina Antonopoulos
  • Si Ming Man
  • Anthony L Desbien
  • Tere M Williams
  • Matthew R Hepworth
  • Todd Douglas
  • Katelynn A Milora
  • Daniel Degrandi
  • Mathias S Dick
  • Roland F Dreier
  • Klaus Pfeffer
  • David E Place
  • Yuji Kajiwara
  • Thomas C Fung
  • Junying Yuan
  • Danielle M Pilla
  • J Yuan
  • D Demon
  • Edward S Mocarski
  • Jon A Hagar
  • Mohamed Lamkanfi
  • R K Subbarao Malireddi
  • William J Kaiser
  • Edward A Miao
  • Thirumala Devi Kanneganti
  • Peter Vogel
  • Cierra N Casson
  • V Sagulenko
  • Christopher L Case
  • Youssef Aachoui
  • Till Strowig
  • Yoshikuni Mizuno
  • Tim Hendrikx
  • Hiroyuki Arai
  • Yun Hee Youm
  • Hideki Mochizuki
  • Richard A Flavell
  • Seth L Masters
  • Katherine A Fitzgerald
  • Beverly H Koller
  • Lukas Bossaller
  • Hana Abdalla
  • Prajwal Gurung
  • MyTrang Nguyen
  • Anwari Akhter
  • Niall S Kenneth
  • James E Vince
  • Jenny P Y Ting
  • Lang Yoo
  • Joerg Ebmeyer
  • Ki Soon Shin
  • Jui Hung Yen
  • Teppei Ikeda
  • Jong Ryoul Choi
  • Hideki Oizumi
  • Dachuan Huang
  • Jong Min Lee
  • M Miura
  • Shamima Islam
  • Motoyoshi Endo
  • Toru Yasuda
  • Hideki Hayakawa
  • Yan Bin Yin
  • M Van de Craen
  • Alexandra Benchoua
  • Masayuki Miura
  • Yunhao Tan
  • Marco Di Gioia
  • Feng Shao
  • Gunnar C Hansson

Detail Information

Publications72

  1. ncbi Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE
    S Wang
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 271:20580-7. 1996
    ..Ich-3 does not process proIL-1beta directly but does promote proIL-1beta processing by ICE. These results suggest that Ich-3 may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE...
  2. pmc Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis
    D Demon
    1 Department of Medical Protein Research, VIB, Ghent, Belgium 2 Department of Biochemistry, Ghent University, Ghent, Belgium
    Mucosal Immunol 7:1480-91. 2014
    ..Moreover, DSS-induced inflammasome activation relied on caspase-1, but not caspase-11. These results suggest a role for other caspase-11 effector mechanisms such as pyroptosis in protection against intestinal inflammation...
  3. pmc Caspase-11 activation in response to bacterial secretion systems that access the host cytosol
    Cierra N Casson
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 9:e1003400. 2013
    ..pneumophila. Our findings demonstrate that virulent, but not avirulent, bacteria trigger a rapid caspase-11-dependent innate immune response important for host defense...
  4. ncbi Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response
    S J Kang
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Cell Death Differ 9:1115-25. 2002
    ..Furthermore, we show that caspase-11-mediated apoptosis under septic condition is Bid-independent. Our work suggests that the human homologue of caspase-11 may be an effective therapeutic target for treatment of septic shock...
  5. ncbi Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1
    Reinout Schauvliege
    Department of Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    J Biol Chem 277:41624-30. 2002
    ..In the case of interferon-gamma stimulation, signal transducer and activator of transcription 1 binding to the caspase-11 promoter could be shown to be required for caspase-11 expression...
  6. ncbi Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization
    Juying Li
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Nat Cell Biol 9:276-86. 2007
    ..These data demonstrate a novel cell autonomous caspase-mediated mechanism that regulates actin dynamics and mammalian cell migration distinct from the receptor mediated Rho-Rac-Cdc42 pathway...
  7. pmc Caspase-11 protects against bacteria that escape the vacuole
    Youssef Aachoui
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Science 339:975-8. 2013
    ..thailandensis and B. pseudomallei. Thus, caspase-11 is critical for surviving exposure to ubiquitous environmental pathogens...
  8. pmc Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination
    S Hisahara
    Division of Neuroanatomy, Department of Neuroscience, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Exp Med 193:111-22. 2001
    ..Our findings suggest that OLG death is mediated by a pathway that involves caspases-11 and -3 and leads to the demyelination observed in EAE...
  9. pmc Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity
    Juying Li
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 181:321-33. 2008
    ..Our study provides a new mechanism controlling the localization and activation of proinflammatory caspases...
  10. pmc Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila
    Christopher L Case
    Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 110:1851-6. 2013
    ....
  11. pmc Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation
    Jui Hung Yen
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 114:1344-54. 2009
    ....
  12. pmc Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens
    Prajwal Gurung
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 287:34474-83. 2012
    ..typhimurium. Thus, TLR4- and TRIF-induced caspase-11 synthesis is critical for noncanonical Nlrp3 inflammasome activation in macrophages infected with enteric pathogens...
  13. pmc Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
    Petr Broz
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, California 94305, USA
    Nature 490:288-91. 2012
    ..This study also highlighted that previously generated caspase-1 knockout mice lack a functional allele of Casp11 (also known as Casp4), making them functionally Casp1 Casp11 double knockouts...
  14. pmc TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 150:606-19. 2012
    ..The identification of TRIF as a regulator of caspase-11 underscores the importance of TLRs as master regulators of inflammasomes during Gram-negative bacterial infection...
  15. pmc Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization
    Anwari Akhter
    Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Immunity 37:35-47. 2012
    ..However, caspase-11 was dispensable for the fusion of lysosomes with phagosomes containing nonpathogenic bacteria, uncovering a fundamental difference in the trafficking of phagosomes according to their cargo...
  16. doi Non-canonical inflammasome activation targets caspase-11
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
    Nature 479:117-21. 2011
    ..Here we show, with C57BL/6 Casp11 gene-targeted mice, that caspase-11 (also known as caspase-4) is critical for caspase-1 activation and IL-1β ..
  17. ncbi Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
    S Wang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 92:501-9. 1998
    ..Our data suggest that caspase-11 is a component of ICE complex and is required for the activation of ICE...
  18. pmc AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
    V Sagulenko
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Cell Death Differ 20:1149-60. 2013
    ..Thus caspase-8 is an integral part of the inflammasome, and this extends the relevance of the inflammasome to cell types that do not express caspase-1. ..
  19. pmc A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion
    George M H Birchenough
    Department of Medical Biochemistry, University of Gothenburg, 40530 Gothenburg, Sweden
    Science 352:1535-42. 2016
    ..Thus, senGCs guard and protect the colonic crypt from bacterial intruders that have penetrated the inner mucus layer. ..
  20. pmc Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging
    Yun Hee Youm
    Pennington Biomedical Research Center, LSU System, Baton Rouge, LA 70808, USA
    Cell Metab 18:519-32. 2013
    ..These studies reveal Nlrp3 inflammasome as an upstream target that controls age-related inflammation and offer an innovative therapeutic strategy to lower Nlrp3 activity to delay multiple age-related chronic diseases...
  21. doi Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
    James E Vince
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:215-27. 2012
    ....
  22. pmc Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice
    Tim Hendrikx
    Departments of Molecular Genetics, Electron Microscopy and Internal Medicine, Nutrition and Toxicology Research NUTRIM Institute of Maastricht and Maastricht University Medical Centre MUMC, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 8:e78792. 2013
    ..We hypothesized that inflammasome activation in KCs stimulates cholesterol crystallization, thereby leading to hepatic inflammation...
  23. pmc Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS
    Danielle M Pilla
    Departments of Molecular Genetics and Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710
    Proc Natl Acad Sci U S A 111:6046-51. 2014
    ..These data suggest a role for Gbp(chr3) proteins in the detection of cytoplasmic LPS and the activation of the noncanonical inflammasome. ..
  24. doi Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases
    Etienne Meunier
    Focal Area Infection Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Nature 509:366-70. 2014
    ..These results indicate that host-mediated lysis of pathogen-containing vacuoles is an essential immune function and is necessary for efficient recognition of pathogens by inflammasome complexes in the cytosol. ..
  25. pmc A critical role for human caspase-4 in endotoxin sensitivity
    Yuji Kajiwara
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029
    J Immunol 193:335-43. 2014
    ..Regulation of the expression, activation, or activity of caspase-4 therefore represents targets for systemic inflammatory response syndrome, sepsis, septic shock, and related disorders. ..
  26. pmc Caspase-1-independent interleukin-1β is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity
    David E Place
    Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania, United States of America Graduate Program in Immunology and Infectious Diseases, Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS ONE 9:e107188. 2014
    ..These findings demonstrate that caspase-1-independent host factors are involved in the processing of protective IL-1β responses that are critical for bacterial clearance and vaccine-mediated immunity. ..
  27. doi Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ
    Anthony L Desbien
    Infectious Disease Research Institute, Seattle, WA, USA
    Eur J Immunol 45:407-17. 2015
    ....
  28. pmc Caspase-11 attenuates gastrointestinal inflammation and experimental colitis pathogenesis
    Tere M Williams
    Virginia Tech, Virginia Maryland Regional College of Veterinary Medicine, Department of Biomedical Sciences and Pathobiology, Blacksburg, Virginia
    Am J Physiol Gastrointest Liver Physiol 308:G139-50. 2015
    ..noncanonical inflammasome during inflammatory bowel disease, experimental colitis was induced in wild-type and Casp11(-/-) mice utilizing dextran sulfate sodium (DSS)...
  29. pmc The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
    Si Ming Man
    1 Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA 2 School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia
    Nat Immunol 16:467-75. 2015
    ..Our results reveal a specific requirement for IRF1 and GBPs in the liberation of DNA for sensing by AIM2 depending on the pathogen encountered by the cell. ..
  30. pmc Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida
    Etienne Meunier
    Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland
    Nat Immunol 16:476-84. 2015
    ..novicida and promoted bacteriolysis. Thus, in addition to their role in host defense against vacuolar pathogens, GBPs also facilitate the presentation of ligands by directly attacking cytosolic bacteria. ..
  31. pmc Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells
    Matthew R Hepworth
    Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I Weill Department of Medicine, Gastroenterology Division, and Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, NY, USA
    Science 348:1031-5. 2015
    ..Collectively, these results define a selection pathway for commensal bacteria-specific CD4(+) T cells in the intestine and suggest that this process is dysregulated in human IBD. ..
  32. pmc Cutting Edge: Caspase-11 Limits the Response of CD8+ T Cells to Low-Abundance and Low-Affinity Antigens
    Tessa Bergsbaken
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98109
    J Immunol 195:41-5. 2015
    ..We report that caspase-11-deficient (Casp11(-/-)) T cells proliferated more readily in response to low-affinity and low-abundance ligands both in vitro and in ..
  33. pmc Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
    Christina Antonopoulos
    Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
    J Biol Chem 290:20167-84. 2015
    ..In the presence of caspase-1, caspase-8 acts as a positive modulator of the NLRP3-dependent caspase-1 signaling cascades that drive both IL-1β production and pyroptotic death. ..
  34. pmc Unprocessed Interleukin-36α Regulates Psoriasis-Like Skin Inflammation in Cooperation With Interleukin-1
    Katelynn A Milora
    Department of Microbiology and Immunology and Temple Autoimmunity Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 135:2992-3000. 2015
    ..In conclusion, IL-1α and IL-36α form a self-amplifying inflammatory loop in vivo that in patients with insufficient counter regulatory mechanisms may become hyper-engaged and/or chronic. ..
  35. doi The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice
    Todd Douglas
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3G 0B1, Canada
    J Immunol 195:2365-73. 2015
    ..These results position the inflammasome as an important initiating signal in skin disease pathogenesis and provide novel insights about inflammasome and cell death effector cross-talk in the context of inflammatory diseases...
  36. doi Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
    Nature 526:666-71. 2015
    ..Our data identify gasdermin D as a critical target of caspase-11 and a key mediator of the host response against Gram-negative bacteria. ..
  37. pmc An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
    Ivan Zanoni
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, MA, USA Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy Unit of Cell Signalling and Innate Immunity, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Science 352:1232-6. 2016
    ..The cells and receptors of the innate immune system can therefore achieve different activation states, which may permit context-dependent responses to infection. ..
  38. ncbi Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis
    Shin Jung Kang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:5455-60. 2003
    ..Our study urges caution when considering the inhibition of caspases as a direct therapeutic method for the treatment of chronic neurodegenerative diseases...
  39. ncbi Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    Tsuyoshi Furuya
    Department of Neurology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    J Neurosci 24:1865-72. 2004
    ..The present results indicate that MPTP neurotoxicity may be mediated via activation of the caspase-11 cascade and inflammatory cascade, as well as the mitochondrial apoptotic cascade...
  40. pmc NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice
    Martina Kovarova
    Pulmonary Division, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 189:2006-16. 2012
    ....
  41. pmc An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1
    Niall S Kenneth
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Biochem J 443:355-9. 2012
    ..stem) cell lines derived from the 129 murine strain carry an inactivating mutation within the caspase 11 gene (Casp4) locus [Kayagaki, Warming, Lamkanfi, Vande Walle, Louie, Dong, Newton, Qu, Liu, Heldens, Zhang, Lee, Roose-Girma ..
  42. pmc Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis
    Hana Abdalla
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 7:e40722. 2012
    ..Interleukin-1β (IL-1β) is important for host resistance against Mycobacterium tuberculosis (Mtb) infections. The response of the dendritic cell inflammasome during Mtb infections has not been investigated in detail...
  43. pmc Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner
    Lukas Bossaller
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 189:5508-12. 2012
    ..Hence, Fas controls a novel noncanonical IL-1β activation pathway in myeloid cells, which could play an essential role in inflammatory processes, tumor surveillance, and control of infectious diseases...
  44. pmc NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells
    Seth L Masters
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    Immunity 37:1009-23. 2012
    ..Conversely, NLRP1-deficient mice showed enhanced recovery from chemotherapy and LCMV infection, demonstrating that NLRP1 acts as a cellular sentinel to alert Caspase-1 to hematopoietic and infectious stress...
  45. pmc Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1β levels
    Pamela R Hesker
    Curriculum of Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, USA
    PLoS ONE 7:e51105. 2012
    ..These results are consistent with a model in which pyrin acts to limit the release of IL-1β generated by activation and assembly of inflammasomes in response to subclinical immune challenges...
  46. ncbi Caspase activity is required for nephrogenesis in the developing mouse metanephros
    T Araki
    Department of Neuroanatomy, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Exp Cell Res 248:423-9. 1999
    ..Both ureteric bud branching and nephrogenesis were prevented by caspase inhibition. Our results suggest that caspases are crucial in kidney organogenesis and cell death in the nondifferentiating mesenchyme...
  47. ncbi Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function
    Y Morita
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell Death Differ 8:614-20. 2001
    ..Thus, genetically distinct mechanisms exist for developmental deletion of oocytes via programmed cell death, one of which probably functions as a meiotic quality-control checkpoint that cannot be overridden...
  48. ncbi Caspase-14, a keratinocyte specific caspase: mRNA splice variants and expression pattern in embryonic and adult mouse
    M K Kuechle
    Cell Death Differ 8:868-70. 2001
  49. ncbi Divinations and surprises: genetic analysis of caspase function in mice
    T S Zheng
    Biogen, Inc, Department of Inflammation, Immunology and Cell Biology, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Exp Cell Res 256:67-73. 2000
    ....
  50. ncbi Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies
    J Wang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N311, MSC 1892, Bethesda, MD 20892 18892, USA
    J Cell Sci 113:753-7. 2000
    ..These studies suggest that caspases function in cell signaling events including apoptosis, cell growth and differentiation...
  51. pmc Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death
    K A Roth
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 97:466-71. 2000
    ....
  52. ncbi The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice
    M Los
    Department of Internal Medicine I, Medical Clinics, University of Tubingen, Germany
    Immunity 10:629-39. 1999
  53. ncbi Expression of caspase and BCL-2 apoptotic family members in mouse preimplantation embryos
    G E Exley
    Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA
    Biol Reprod 61:231-9. 1999
    ..This result supports a model in which the ratio of BCL-2 to BAX is altered in apoptotic embryos...
  54. ncbi Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice
    Hiroyuki Arai
    Research Institute for Diseases of Old Ages, Juntendo University School of Medicine, Tokyo, Japan
    J Biol Chem 279:51647-53. 2004
    ..Our results indicate that the neurotoxic effects of LPS on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and caspase-11 expression in mice...
  55. ncbi Targeted disruption of caspase genes in mice: what they tell us about the functions of individual caspases in apoptosis
    P A Colussi
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Immunol Cell Biol 77:58-63. 1999
    ..The present review discusses these recent findings and elaborates on how these mutant mouse models have helped the understanding of the mechanisms that govern programmed cell death in the immune and other systems...
  56. ncbi Prodomains--adaptors--oligomerization: the pursuit of caspase activation in apoptosis
    S Kumar
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Trends Biochem Sci 24:1-4. 1999
  57. ncbi Molecular cloning and identification of murine caspase-8
    M Van de Craen
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology and University of Ghent, K L Ledeganckstraat 35, Ghent, B 9000, Belgium
    J Mol Biol 284:1017-26. 1998
    ..In addition, murine caspase-8 induced cell death that was inhibited both by cytokine response modifier A and p35. In vitro experiments demonstrated that p35 inhibits caspase-8 directly...
  58. ncbi Characterization of seven murine caspase family members
    M Van de Craen
    Flanders Interuniversity Institute for Biotechnology and University of Ghent, Belgium
    FEBS Lett 403:61-9. 1997
    ..Only two, mCASP-1 as well as mCASP-3, were able to process precursor interleukin (IL)-1beta to biologically active IL-1beta. In addition, mCASP-3 is the predominant PARP-cleaving enzyme in vivo...
  59. ncbi Essential role of caspase-11 in activation-induced cell death of rat astrocytes
    Kyoungho Suk
    Department of Herbal Pharmacology, Graduate School of East West Medical Science and Research Institute for Basic Sciences, Kyunghee University, Seoul, Korea
    J Neurochem 80:230-8. 2002
    ..These results indicate that inflammatory stimuli not only induce the production of cytotoxic NO, but also initiate NO-independent apoptotic pathway through the induction of caspase-11 expression...
  60. ncbi In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons
    Masanori Tomioka
    Laboratory for Proteolytic Neuroscience, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Brain Res Mol Brain Res 108:18-32. 2002
    ..These results indicate that p35-inhibitable caspases play rather minor roles in the kainate-induced excitotoxicity and that the relative contribution of calpain is likely to be greater than that of caspases...
  61. ncbi Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia
    Alexandra Benchoua
    Institut National de la Sante et de la Recherche Medicale, Universite Paris Val de Marne, Crétoil, France
    J Cereb Blood Flow Metab 24:1272-9. 2004
    ..This new pathway may play a critical role in brain infarction by promoting inflammatory responses, and/or by amplifying the apoptotic process...
  62. ncbi Comparative study of apoptosis-related gene loci in human, mouse and rat genomes
    Yan Bin Yin
    Center of Bioinformatics, National Laboratory of Genetic Engineering and Protein Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    Acta Biochim Biophys Sin (Shanghai) 37:341-8. 2005
    ..All data produced in this work were stored in a relational database and may be viewed at http://pcas.cbi.pku.edu.cn/database/apd.php...
  63. ncbi Lipopolysaccharide prevents apoptosis induced by brefeldin A, an endoplasmic reticulum stress agent, in RAW 264.7 cells
    Shamima Islam
    Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi 480 1195, Japan
    Biochem Biophys Res Commun 340:589-96. 2006
    ..Therefore, LPS was suggested to diminish the stress of ER/Golgi complexes induced by brefeldin A and inhibit apoptosis. The preventive action of LPS on brefeldin A-induced apoptosis is discussed...
  64. ncbi C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation
    Motoyoshi Endo
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    J Immunol 176:6245-53. 2006
    ..Caspase-11 was also induced by such ER stress inducers as thapsigargin or tunicamycin. These results show that CHOP plays a crucial role in the pathogenesis of inflammation through the induction of caspase-11...
  65. ncbi Alteration in the differentiation-related molecular expression in the subventricular zone in a mouse model of Parkinson's disease
    Hideki Oizumi
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo 113 8421, Japan
    Neurosci Res 60:15-21. 2008
    ..Our results suggest that neuroinflammation related to the caspase-11 cascade in the striatum regulates differentiation of neural stem cells in the SVZ of our mouse model of PD...
  66. ncbi Nitric-oxide synthase 2 interacts with CD74 and inhibits its cleavage by caspase during dendritic cell development
    Dachuan Huang
    Laboratory of Membrane Trafficking and Immunoregulation, Department of Microbiology, Yong Loo Lin School of Medicine
    J Biol Chem 283:1713-22. 2008
    ..Because the trafficking of MHC II is CD74-dependent, the increase in cell surface localization of MHC II in maturing DC is in part due to the increase in CD74 protein expression in the presence of NOS2 and NO...
  67. doi The involvement of caspase-11 in TPEN-induced apoptosis
    Jong Min Lee
    Department of Molecular Biology, Sejong University, 98 Gunja Dong Gwangjin Gu, Seoul 143 747, South Korea
    FEBS Lett 582:1871-6. 2008
    ..Although mitochondria-mediated caspase-9/-3 activation also contributed to TPEN-induced apoptosis, caspase-11 is likely a key inducible apoptosis-inducing protein...
  68. doi Apoptosis signal-regulating kinase 1 regulates the expression of caspase-11
    Jong Ryoul Choi
    Department of Molecular Biology, Sejong University, Seoul 143 747, Republic of Korea
    FEBS Lett 583:3016-20. 2009
    ..Importantly, knockdown or dominant negative form of Ask1 suppressed the induction of caspase-11 following LPS stimulation. Taken together, our results show that Ask1 regulates the expression of caspase-11 following LPS stimulation...
  69. ncbi Expression of caspase family and muscle- and apoptosis-specific genes during skeletal myogenesis in mouse embryo
    Teppei Ikeda
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 71:1161-8. 2009
    ..These results suggest that the activation of Casps in skeletal myogenesis is deeply associated with myoblast differentiation, but not directly related to apoptosis...
  70. pmc TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media
    Joerg Ebmeyer
    Department of Otorhinolaryngology, Head and Neck Surgery Klinikum Bielefeld, Academic Teaching Hospital University of Münster, Bielefeld, Germany
    BMC Immunol 12:12. 2011
    ....
  71. doi PARP-1 regulates the expression of caspase-11
    Lang Yoo
    Department of Molecular Biology, Sejong University, Seoul 143 747, Republic of Korea
    Biochem Biophys Res Commun 408:489-93. 2011
    ..Our results suggest that PARP-1, as a transcriptional cofactor for NF-κB, regulates the induction of caspase-11 at a transcriptional level...