Casp3

Summary

Gene Symbol: Casp3
Description: caspase 3
Alias: A830040C14Rik, AC-3, CASP-3, CC3, CPP-32, CPP32, Caspase-3, Lice, SCA-1, Yama, mldy, caspase-3, SREBP cleavage activity 1, apopain, caspase 3, apoptosis related cysteine protease, cysteine protease CPP32, protein Yama
Species: mouse

Top Publications

  1. ncbi Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteum
    Silvia F Carambula
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 143:1495-501. 2002
  2. ncbi Calcium-induced calpain mediates apoptosis via caspase-3 in a mouse photoreceptor cell line
    Ashish K Sharma
    Department of Ophthalmology, Storm Eye Institute, University of South Carolina, Charleston 29425, USA
    J Biol Chem 279:35564-72. 2004
  3. ncbi Selective up-regulation of caspase-3 gene expression following TCR engagement
    Laurent Sabbagh
    Laboratoire d Immunologie, Centre de Recherche du CHUM, Campus St Luc, Pavillon Edouard Asselin, 264 Boul Rene Levesque Est 1307D, Montreal, Que, Canada H2X 1P1
    Mol Immunol 42:1345-54. 2005
  4. pmc Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
    M Woo
    Amgen Institute Ontario Cancer Institute, Department of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5G2C1, Canada
    Genes Dev 12:806-19. 1998
  5. pmc Executioner caspase-3 and caspase-7 are functionally distinct proteases
    John G Walsh
    Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 105:12815-9. 2008
  6. doi The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
    Konstantin Gaengel
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Dev Cell 23:587-99. 2012
  7. pmc Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein
    Hirotaka Kazama
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 631101, USA
    Immunity 29:21-32. 2008
  8. doi Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β
    Jihoon Jo
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
    Nat Neurosci 14:545-7. 2011
  9. doi Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
    James E Vince
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:215-27. 2012
  10. ncbi Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cereb Cortex 18:1604-17. 2008

Research Grants

  1. Ontogeny of Motor Systems: Neurogenesis to Behavior
    Ronald Oppenheim; Fiscal Year: 2003
  2. NEURONAL DEATH AND SURVIVAL
    Ronald Oppenheim; Fiscal Year: 2003
  3. Neuromuscular Activity: Development and Survival of Avian and Mammalian Neurons
    Ronald W Oppenheim; Fiscal Year: 2010
  4. Motor System Development in the Absence of Cell Death
    Ronald Oppenheim; Fiscal Year: 2007
  5. DEVELOPMENT AND SURVIVAL OF GLIAL CELLS
    Ronald Oppenheim; Fiscal Year: 2001
  6. Vascular inflammation and neurotoxicity in aging brain
    Paula Grammas; Fiscal Year: 2009
  7. The Role of Id2 in Adult Neurogenesis
    MATTHEW HAVRDA; Fiscal Year: 2008
  8. Regulation of PTEN-induced kinase 1 (PINK 1)
    Charleen Chu; Fiscal Year: 2007
  9. Training in proteomics of novel kinase substrates for neurodegeneration
    Charleen Chu; Fiscal Year: 2007
  10. The function of Foxi3 in craniofacial development
    Takahiro Ohyama; Fiscal Year: 2008

Detail Information

Publications214 found, 100 shown here

  1. ncbi Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteum
    Silvia F Carambula
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 143:1495-501. 2002
    ..However, caspase-3 is not a direct mediator of the decrease in steroidogenesis associated with luteolysis...
  2. ncbi Calcium-induced calpain mediates apoptosis via caspase-3 in a mouse photoreceptor cell line
    Ashish K Sharma
    Department of Ophthalmology, Storm Eye Institute, University of South Carolina, Charleston 29425, USA
    J Biol Chem 279:35564-72. 2004
    ..We concluded that Ca(2+) influx in the rd model of photoreceptor degeneration leads to the activation of the cysteine protease calpain, which executes apoptosis via modulation of caspase-3 activity...
  3. ncbi Selective up-regulation of caspase-3 gene expression following TCR engagement
    Laurent Sabbagh
    Laboratoire d Immunologie, Centre de Recherche du CHUM, Campus St Luc, Pavillon Edouard Asselin, 264 Boul Rene Levesque Est 1307D, Montreal, Que, Canada H2X 1P1
    Mol Immunol 42:1345-54. 2005
    ..Together, these results show that TCR activation triggers the selective increase in caspase-3 mRNA levels, independently of caspase activity and the induction of apoptosis...
  4. pmc Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
    M Woo
    Amgen Institute Ontario Cancer Institute, Department of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5G2C1, Canada
    Genes Dev 12:806-19. 1998
    ..CPP32 (caspase 3) is a prototypical caspase that becomes activated during apoptosis...
  5. pmc Executioner caspase-3 and caspase-7 are functionally distinct proteases
    John G Walsh
    Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 105:12815-9. 2008
    ..Our observations provide a molecular basis for the different phenotypes seen in mice lacking either caspase and indicate that these proteases occupy nonredundant roles within the cell death machinery...
  6. doi The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
    Konstantin Gaengel
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Dev Cell 23:587-99. 2012
    ..Our data suggest that S1PR1 signaling acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses...
  7. pmc Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein
    Hirotaka Kazama
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 631101, USA
    Immunity 29:21-32. 2008
    ..Similarly, blocking sites of oxidation in HMGB1 prevented tolerance induction by apoptotic cells. These results suggest that caspase-orchestrated mitochondrial events determine the impact of apoptotic cells on the immune response...
  8. doi Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β
    Jihoon Jo
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
    Nat Neurosci 14:545-7. 2011
    ..We found that a signaling pathway involving caspase-3, Akt1 and glycogen synthase kinase-3β is an important mediator of this effect in rats and mice...
  9. doi Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
    James E Vince
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:215-27. 2012
    ....
  10. ncbi Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cereb Cortex 18:1604-17. 2008
    ..In Sall1-mutant animals, these patterns of neurogenesis were disrupted. These findings suggest a role for Sall1 in regulating neuronal differentiation and maturation in developing neural structures...
  11. pmc The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation
    Sayan Nandi
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Dev Biol 367:100-13. 2012
    ..Thus our results also indicate novel roles for the CSF-1R in the regulation of corticogenesis...
  12. ncbi Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion
    Chiara Rigato
    Institut National de la Sante et de la Recherche Medicale, U952, Universite Pierre et Marie Curie, Paris, Ile de France, France
    J Neurosci 32:11559-73. 2012
    ..These results reveal a developmental role of P2X7R by controlling embryonic SC microglia proliferation at a critical developmental state in the SC of mouse embryos...
  13. ncbi Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
    K Kuida
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 384:368-72. 1996
    ..Among the ten or more members of the ICE protease family, CPP32/yama/apopain exhibits the highest similarity to CED-3 in both sequence homology and substrate specificity...
  14. ncbi Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease
    V Viswanath
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 21:9519-28. 2001
    ..These data suggest that caspase inhibitors constitute a plausible therapeutic for PD...
  15. doi Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals
    Zohar Schoenmann
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 30:6375-86. 2010
    ..These findings indicate that two distinct autodestruction pathways act separately or in concert to regulate developmental neurite pruning...
  16. doi Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex
    Lilla M Farkas
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Neuron 60:40-55. 2008
    ..Our data imply that Insm1 is involved in the generation and expansion of basal progenitors, a hallmark of neocortex evolution...
  17. pmc Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development
    Jianquan Chen
    Department of Biology, University of Rochester, Rochester, New York 14642, USA
    Dev Biol 334:174-85. 2009
    ..Together, these results indicate that activation of the mesenchymal odontogenic program during early tooth development requires concerted actions of Bmp, Fgf and Wnt signaling from the presumptive dental epithelium to the mesenchyme...
  18. pmc Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development
    Qingru Wang
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Dev Biol 288:582-94. 2005
    ..These data provide new insights into the molecular mechanisms underlying heart morphogenesis and urogenital development...
  19. pmc Overexpression of thioredoxin-1 reduces oxidative stress in the placenta of transgenic mice and promotes fetal growth via glucose metabolism
    Takashi Umekawa
    Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Endocrinology 149:3980-8. 2008
    ..In particular, increased hTRX-1 activity and the resulting modified placental redox state may play an important role in fetal growth by increasing the availability of glucose...
  20. pmc Caveolin-1-dependent apoptosis induced by fibrin degradation products
    Yi He Guo
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226 3548, USA
    Blood 113:4431-9. 2009
    ....
  21. pmc Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity
    Shizue Ohsawa
    Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 107:13366-71. 2010
    ..Our findings suggest that Apaf-1/caspase-9-mediated nonapoptotic caspase signaling is required for the proper neural network formation during olfactory development...
  22. ncbi Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival
    Ken ichiro Kuwako
    Institute for Protein Research, Osaka University, Osaka 565 0871, Japan
    J Neurosci 25:7090-9. 2005
    ..These results suggest that paternally expressed necdin facilitates TrkA signaling to promote the survival of NGF-dependent nociceptive neurons...
  23. ncbi Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis
    Lizhu Lin
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Dev Biol 295:756-63. 2006
    ..We find that expression of npn2 is downregulated in isl1-cre;smo mutants, suggesting an isl1/Shh/npn pathway required to affect morphogenesis at the anterior pole of the heart...
  24. doi Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling
    Helen A Thomason
    Faculty of Medical and Human Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, England, UK
    Dev Biol 321:273-82. 2008
    ..Our results are consistent with a role for Tp63 in the regulation of Bmp signaling controlling the growth, modelling and fusion events underlying facial development and shed new light on the complex abnormality of facial clefting...
  25. ncbi Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
    S Wang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 92:501-9. 1998
    ..Our data suggest that caspase-11 is a component of ICE complex and is required for the activation of ICE...
  26. pmc Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation
    Jui Hung Yen
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 114:1344-54. 2009
    ....
  27. ncbi Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts
    Lanying Song
    Division of Genetic and Translational Medicine, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Dev Biol 301:276-86. 2007
    ..Taken together, our study supports the notion that Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis...
  28. pmc High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma
    David S Hains
    Division of Nephrology, Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio, USA
    J Urol 183:2077-84. 2010
    ..We determined whether Fgfr2(Mes-/-) mutants developed abnormally positioned ureters predisposing to vesicoureteral reflux...
  29. pmc A role for FE65 in controlling GnRH-1 neurogenesis
    Paolo E Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:480-91. 2011
    ....
  30. ncbi Detection of activated caspase-3 (CPP32) in the vertebrate nervous system during development by a cleavage site-directed antiserum
    K Urase
    Division of Development and Differentiation, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Brain Res Dev Brain Res 111:77-87. 1998
    ..Mukasa, K. Urase, Y.M. Momoi, I. Kimura, T. Momoi, Specific expression of CPP32 in sensory neurons of mouse embryos and activation of CPP32 in the apoptosis induced by a withdrawal of NGF, ..
  31. ncbi F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis
    S L Chan
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Republic of Singapore
    J Biol Chem 274:32461-8. 1999
    ..F1Aalpha is therefore a member of a growing family of death receptor-associated proteins that mediates apoptosis...
  32. pmc Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina
    Liang Feng
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 133:4815-25. 2006
    ..Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes...
  33. doi Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy
    Ronald W Oppenheim
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 28:1490-7. 2008
    ..e., caspases and Apaf-1) are perturbed in vivo, developing postmitotic neurons nonetheless undergo quantitatively normal PCD by a caspase-independent pathway involving autophagy and not requiring AIF...
  34. doi Mouse vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetes
    C Roisin-Bouffay
    Aix Marseille Universite, Faculte des Sciences de Luminy, Centre d immunologie de Marseille Luminy, Marseille, France
    Diabetologia 51:1192-201. 2008
    ..The epithelial pantetheinase vanin-1 is proinflammatory and cytoprotective via cysteamine release in some tissues. We investigated the impact of a vanin-1 deficiency on islet death and type 1 diabetes incidence...
  35. doi Apaf-1-independent programmed cell death in mouse development
    A Nagasaka
    Department of Medical Chemistry, Kyoto University, Yoshida Konoe, Sakyo ku, Japan
    Cell Death Differ 17:931-41. 2010
    ..Thus, programmed cell death in mouse development, which normally proceeds in an efficient Apaf-1-depenent mechanism, appears to be backed up by Apaf-1-independent death systems...
  36. pmc Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma
    Sharyn I Katz
    Laboratory of Molecular Oncology and Cell Cycle Regulation, Department of Medicine Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Cancer Biol Ther 8:2406-16. 2009
    ..We document single agent activity of sorafenib against MPM, unravel novel effects of sorafenib on anti-apoptotic signaling mediators, and suggest the combination of sorafenib plus TRAIL as possible therapy for clinical testing in MPM...
  37. pmc Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA
    Dev Biol 350:112-26. 2011
    ..We conclude, therefore, that Eya1 function is critical for proper coordination of lung epithelial, mesenchymal and vascular development...
  38. pmc Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development
    Vesna Todorovic
    Department of Cell Biology, NYU Langone Medical Center, New York, New York 10016, USA
    Dev Dyn 240:176-87. 2011
    ..We demonstrate that Ltbp1L is a major regulator of Tgf-β activity during valvulogenesis since its absence results in a perturbed Tgf-β pathway that causes all Ltbp1L(-/-) valvular defects...
  39. pmc α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice
    Amparo Girós
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Burjassot, Spain
    PLoS ONE 6:e22002. 2011
    ..Thus, α5β1-mediated adhesion to FN in the PSM regulates the dynamics of membrane protrusions and cell-to-cell communication essential for elongation and segmentation of the body axis...
  40. doi Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea
    Takayuki Okano
    Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland 20892, USA
    J Neurosci 31:18104-18. 2011
    ..The results also provide new insights regarding the pathological processes that underlie auditory defects in the absence of IGF signaling in both humans and mice...
  41. doi Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning
    Deanna G Wilson
    Genentech, South San Francisco, CA 94080, USA
    Dev Biol 363:413-25. 2012
    ..Our results place Chsy1 as an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1...
  42. doi Loss of the Prader-Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neurons
    Alysa A Tennese
    Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada
    Dev Dyn 237:1935-43. 2008
    ..Furthermore, reduced sympathetic function provides a plausible explanation for deficiencies of salivary gland function in individuals with congenital necdin deficiency consequent to Prader-Willi syndrome...
  43. pmc Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain
    John Jacob
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 136:2477-85. 2009
    ..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations...
  44. doi A novel transient glutamatergic population migrating from the pallial-subpallial boundary contributes to neocortical development
    Anne Teissier
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 7592, Institut Jacques Monod, Universite Paris Diderot, 75205 Paris Cedex 13, France
    J Neurosci 30:10563-74. 2010
    ....
  45. ncbi Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling
    Vesna Todorovic
    Cell Biology Department, NYU School of Medicine, New York, NY 10016, USA
    Development 134:3723-32. 2007
    ..This phenotype reveals a crucial role for Ltbp1L and matrix as extracellular regulators of Tgf-beta activity in heart organogenesis...
  46. pmc ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells
    Ling Pan
    Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA
    Development 135:1981-90. 2008
    ..Thus, our results uncover a novel regulatory mechanism of BRN3B and ISL1 in RGC differentiation...
  47. pmc Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells
    Irene Puga
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Immunity 29:193-204. 2008
    ..Casp3 is one of the genes activated during anergy induction. Here we show that caspase 3 is required for the induction of T cell unresponsiveness...
  48. ncbi CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme
    T Fernandes-Alnemri
    Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    J Biol Chem 269:30761-4. 1994
    ..The new gene encodes a 32-kDa putative cysteine protease (CPP32) with significant homology to Caenorhabditis elegans cell death protein Ced-3, mammalian interleukin-1 beta-..
  49. ncbi Akt negatively regulates translation of the ternary complex factor Elk-1
    Claudia Figueroa
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 0606, USA
    Oncogene 22:5554-61. 2003
    ..We conclude that Akt negatively regulates translation of the Elk-1 mRNA. A coding region determinant that maps within the first 279 nts of the Elk-1 message is necessary and sufficient for Akt-mediated regulation of Elk-1...
  50. pmc Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis
    Jiang Chang
    Center for Molecular Development and Disease, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:14495-500. 2006
    ..These data suggest an obligatory role for ROCK-1 cleavage in promoting apoptotic signals in myocardial hypertrophy and/or failure...
  51. pmc BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons
    Qian Ding
    University of Rochester Eye Institute, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 29:3992-4003. 2009
    ..Thus, BARHL2 appears to have numerous roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival...
  52. ncbi In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
    A Srinivasan
    Idun Pharmaceuticals, Inc, La Jolla, California 92037, USA
    Cell Death Differ 5:1004-16. 1998
    ..These studies indicate that caspase-3 is activated during apoptosis in the developing nervous system in vivo and that CM1 is a useful reagent for its in situ detection...
  53. ncbi Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss
    K Takahashi
    Department of Otolaryngology Head and Neck Surgery, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi gun, 329 0498, Tochigi, Japan
    Brain Res 894:359-67. 2001
    ....
  54. ncbi Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary
    T Matikainen
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston 02114, USA
    Endocrinology 142:2468-80. 2001
    ..We conclude that caspase-3 is functionally required for granulosa cell apoptosis during follicular atresia, but that the enzyme is dispensable for germ cell apoptosis in the female...
  55. pmc Math5 is required for retinal ganglion cell and optic nerve formation
    N L Brown
    Departments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Development 128:2497-508. 2001
    ..A small number of nascent RGCs are detected during embryogenesis, but these fail to develop further, suggesting that committed RGCs may also require Math5 function...
  56. ncbi Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 15:525-30. 2005
    ..Intrinsic rather than extrinsic factors are likely to play the critical roles in determining retinal cell fate...
  57. pmc Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes
    Anne M Moon
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Dev Cell 10:71-80. 2006
    ..These findings provide mechanistic insight into disrupted intercellular interactions in the pathogenesis of malformations seen in del22q11 syndrome...
  58. ncbi Retinoblastoma family proteins: insights gained through genetic manipulation of mice
    K A Wikenheiser-Brokamp
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Ohio, 45267 0529, USA
    Cell Mol Life Sci 63:767-80. 2006
    ..This review summarizes the phenotypic consequences of Rb family ablation in mice, and discusses how these findings contribute to the increasingly complex picture of Rb family function in development and tumor suppression...
  59. pmc alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway
    Wen Hui Lien
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 311:1609-12. 2006
    ..We propose that alphaE-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex...
  60. ncbi UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1
    Megan E Williams
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
    Nat Neurosci 9:996-8. 2006
    ..In contrast, loss of netrin-1 (Ntn1) did not affect the amount of apoptosis, suggesting that NTN1 is not required for neuronal apoptosis in vivo...
  61. pmc Canonical notch signaling functions as a commitment switch in the epidermal lineage
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 20:3022-35. 2006
    ....
  62. pmc The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion
    Margaret E McLaughlin
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:3261-6. 2007
    ..Our work reveals that regulation of Nf2 expression is a previously unrecognized means of controlling adhesion at the leading front, thereby ensuring successful tissue fusion...
  63. pmc Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions
    Kelly A McClellan
    Department of Cellular and Molecular Medicine, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada
    Mol Cell Biol 27:4825-43. 2007
    ..This study not only outlines overlapping and distinct functions for E2Fs in neurogenesis but also is the first to establish a physiologically relevant role for the Rb/E2F pathway beyond cell cycle regulation in vivo...
  64. pmc Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype
    Vladimir N Simirskii
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Dev Biol 306:658-68. 2007
    ..Thus, beta1-integrin is required to maintain the lens epithelial phenotype and block inappropriate activation of some aspects of the lens fiber cell differentiation program...
  65. pmc Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems
    Merritt K Taylor
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Development 134:2435-47. 2007
    ..These results demonstrate that physiological Notch signaling is required for gliogenesis in vivo, independent of the role of Notch in the maintenance of undifferentiated neural progenitors...
  66. pmc In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea
    Huansheng Xu
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030, USA
    Dev Biol 310:329-40. 2007
    ..This model provides a striking demonstration of the essential role played by the periotic mesenchyme in the organogenesis of the cochlea...
  67. ncbi Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone
    Beatriz Cubelos
    Centro Nacional de Biotecnologia, CSIC, Darwin 3, Campus de Cantoblanco, Madrid 28049, Spain
    Cereb Cortex 18:1758-70. 2008
    ..Our results point to Cux-2 as a key element in the control of the proliferation rates of the SVZ precursors and the number of upper cortical neurons, without altering the number of deep cortical layers...
  68. doi The role of IL-6 and IL-11 in hyperoxic injury in developing lung
    Anne Chetty
    Department of Pediatrics, Floating Hospital for Children, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Pediatr Pulmonol 43:297-304. 2008
    ..IL-11 and IL-6 provide protective effects against oxidant-mediated injury in fetal type II cells and IL-11 provides protection in vivo by down-regulation of caspase-mediated cell death...
  69. pmc Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells
    Marion Dejosez
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
    Cell 133:1162-74. 2008
    ..Our findings identify Ronin as an essential factor underlying embryogenesis and ES cell pluripotency. Its association with HCF-1 suggests an epigenetic mechanism of gene repression in pluripotent cells...
  70. pmc Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function
    IVY S SAMUELS
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106 4928, USA
    J Neurosci 28:6983-95. 2008
    ..These findings demonstrate an important role for ERK2 in cellular proliferation and differentiation during neural development as well as in cognition and memory formation...
  71. pmc Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear
    Min Deng
    University of Rochester Flaum Eye Institute, University of Rochester, Rochester, NY 14642, USA
    Dev Biol 338:38-49. 2010
    ....
  72. ncbi Characterization of seven murine caspase family members
    M Van de Craen
    Flanders Interuniversity Institute for Biotechnology and University of Ghent, Belgium
    FEBS Lett 403:61-9. 1997
    ..were cloned and functionally characterized by transient overexpression: mCASP-1 (mICE), mCASP-2 (Ich1), mCASP-3 (CPP32), mCASP-6 (Mch2), mCASP-7 (Mch3), mCASP-11 (TX) and mCASP-12...
  73. ncbi Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
    K Kuida
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 94:325-37. 1998
    ..Casp9 deletion prevents activation of Casp3 in embryonic brains in vivo, and Casp9-deficient thymocytes show resistance to a subset of apoptotic stimuli, ..
  74. ncbi Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
    F Cecconi
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Cell 94:727-37. 1998
    ..elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of CASP3 in the general apoptotic pathway. We have generated by gene trap a null allele of the murine Apaf1...
  75. pmc Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm
    Y Lee
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 14:2576-80. 2000
    ..Therefore, ATM could be important for preventing accumulation of DNA-damaged cells in the nervous system that might eventually lead to the neurodegeneration observed in ataxia telangiectasia...
  76. ncbi Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice
    M C Vemuri
    Program in Neuroscience and Behavior, Department of Biology, Wesleyan University, Middletown, CT 06457, USA
    Cell Death Differ 8:245-55. 2001
    ..Additional biochemical and immunocytochemical studies indicated that of several DNA repair enzymes investigated, only PARP was increased in scid mice, possibly in response to elevated DNA strand breaks...
  77. ncbi Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice
    Jeffrey R Leonard
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neuropathol Exp Neurol 61:673-7. 2002
    ....
  78. ncbi Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development
    Akihiro Nishida
    Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Nat Neurosci 6:1255-63. 2003
    ..Thus, Otx2 is a key regulatory gene for the cell fate determination of retinal photoreceptor cells. Our results reveal the key molecular steps required for photoreceptor cell-fate determination and pinealocyte development...
  79. ncbi High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism
    Ryuhei Okuyama
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Dev Cell 6:551-62. 2004
    ..promotes keratinocyte differentiation, is upregulated in embryonic keratinocyte and epidermis, and elevated caspase 3 expression, which we identify as a transcriptional Notch1 target, accounts in part for the high commitment of ..
  80. ncbi The transcription factor Bhlhb4 is required for rod bipolar cell maturation
    Debra E Bramblett
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 43:779-93. 2004
    ..Other retinal cell populations including photoreceptors were unaltered. The timing of RB cell depletion in the Bhlhb4(-/-) mouse suggests that Bhlhb4 is essential for RB cell maturation...
  81. pmc A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
    Masako Miura
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research NIDCR, NIH, Bethesda, MD 20892, USA
    J Clin Invest 114:1704-13. 2004
    ..Here we report delayed ossification and decreased bone mineral density in caspase-3-deficient (Casp3(-/-) and Casp3(+/-)) mice due to an attenuated osteogenic differentiation of bone marrow stromal stem cells (..
  82. ncbi Neural stem cell differentiation is dependent upon endogenous caspase 3 activity
    Pasan Fernando
    Ottawa Health Research Institute, Molecular Medicine Program, Ottawa, Ontario, Canada
    FASEB J 19:1671-3. 2005
    ..These results implicate caspase-3 activation as a conserved feature of neuronal differentiation and suggest that targeted inhibition of this protease in neural cell populations may have unintended consequences...
  83. pmc Caspases 3 and 7: key mediators of mitochondrial events of apoptosis
    Saquib A Lakhani
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 311:847-51. 2006
    ..We generated mice deficient in the two effectors, caspase 3 and caspase 7, which died immediately after birth with defects in cardiac development...
  84. pmc SOX2 is a dose-dependent regulator of retinal neural progenitor competence
    Olena V Taranova
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA
    Genes Dev 20:1187-202. 2006
    ....
  85. pmc Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death
    David Andrieu
    Institut de Biologie du Developpement de Marseille Luminy, Campus de Luminy Case 907 13288 Marseille Cedex 09, France
    BMC Dev Biol 6:56. 2006
    ..In this study, we investigate sensory-motor behaviour in Necdin deficient mice. We reveal cellular defects and analyse their cause...
  86. pmc BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms
    Arnaud A Mailleux
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 12:221-34. 2007
    ..These data provide important mechanistic information on the processes involved in sculpting the mammary gland and demonstrate that BIM is a critical regulator of apoptosis in vivo...
  87. pmc Human and murine granzyme B exhibit divergent substrate preferences
    Sean P Cullen
    Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
    J Cell Biol 176:435-44. 2007
    ..These data demonstrate that human and murine GzmB are distinct enzymes with different substrate preferences. Our observations also illustrate how subtle differences in enzyme structure can radically affect substrate selection...
  88. pmc Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis
    Alice T Shaw
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston 02114, USA
    Genes Dev 21:694-707. 2007
    ..These findings indicate that in the lung, Sprouty-2 plays a critical role in the regulation of oncogenic K-ras, and implicate counter-regulatory mechanisms in the pathogenesis of Ras-based disease...
  89. ncbi LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
    Anthony P Barnes
    Neuroscience Center, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 129:549-63. 2007
    ..Thus, we provide evidence in vivo and in vitro for a multikinase pathway that links extracellular signals to the intracellular machinery required for axon specification...
  90. pmc Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development
    Tamara Terzian
    Department of Cancer Genetics, Box 1010, The University of Texas M D Anderson Cancer Center, Baylor College of Medicine, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell Biol 27:5479-85. 2007
    ..These findings highlight the exquisite sensitivity of p53 to Mdm2 and Mdm4 levels and suggest that some cell types may be more sensitive to therapeutic drugs that inhibit the Mdm-p53 interaction...
  91. pmc The RGD motif in fibronectin is essential for development but dispensable for fibril assembly
    Seiichiro Takahashi
    Max Planck Institute of Biochemistry, Department of Molecular Medicine, 82152 Martinsried, Germany
    J Cell Biol 178:167-78. 2007
    ..Our findings demonstrate that FN contains a novel motif for integrin binding and fibril formation whose activity is controlled by amino acid modification...
  92. ncbi Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2
    Wenlai Zhou
    Howard Hughes Medical Institute and Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Nat Genet 39:1225-34. 2007
    ..Thus, we propose that transcriptional readout mediated at least in part by a Wnt11 --> ATF/CREB --> TGFbeta2 pathway is critical in regulating morphogenesis in response to noncanonical Wnt signaling...
  93. pmc N-myc coordinates retinal growth with eye size during mouse development
    Rodrigo A P Martins
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Genes Dev 22:179-93. 2008
    ..We propose that N-myc lies upstream of the cell cycle machinery in the developing mouse retina and thus coordinates the growth of both the retina and eye through extrinsic cues...
  94. pmc Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation
    Evan M Braunstein
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Assoc Res Otolaryngol 9:33-43. 2008
    ....
  95. pmc Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
    Matthew J Hilton
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:306-14. 2008
    ..Thus, mesenchymal progenitors may be expanded in vitro by activating the Notch pathway, whereas bone formation in vivo may be enhanced by transiently suppressing this pathway...
  96. pmc Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells
    Tatsuya Katsuno
    Laboratory of Biological Science, Graduate School of Frontier Biosciences, and Graduate School of Medicine, Osaka University, Japan
    Mol Biol Cell 19:2465-75. 2008
    ..In conclusion, ZO-1 may be functionally important for cell remodeling and tissue organization in both the embryonic and extraembryonic regions, thus playing an essential role in embryonic development...
  97. doi Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation
    Nicholas Warr
    Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 17:2986-96. 2008
    ..The analysis provides genetic evidence that Zic2 functions during organizer formation and that the PCP develops via a multi-step process...
  98. pmc NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo
    M J M Bertrand
    URPHYM Unité de Recherches en Physiologie Moléculaire, FUNDP School of Medicine, University of Namur, Namur, Belgium
    Cell Death Differ 15:1921-9. 2008
    ..Together, these studies demonstrate that NRAGE plays an important role in apoptotic-signaling in vivo...
  99. doi A non-apoptotic role for caspase-9 in muscle differentiation
    Thomas V A Murray
    National Centre for Biomedical Engineering Science and Department of Pharmacology and Therapeutics, National University of Ireland, Galway, Ireland
    J Cell Sci 121:3786-93. 2008
    ....
  100. doi Specific glial populations regulate hippocampal morphogenesis
    Guy Barry
    The University of Queensland, Queensland Brain Institute, and School of Biomedical Sciences, Brisbane, 4067, Australia
    J Neurosci 28:12328-40. 2008
    ..These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis...
  101. pmc Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS
    Erin R P Shull
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 23:171-80. 2009
    ..Thus, DNA damage signaling in the nervous system is different between ATLD and NBS and likely explains their respective neuropathology...

Research Grants31

  1. Ontogeny of Motor Systems: Neurogenesis to Behavior
    Ronald Oppenheim; Fiscal Year: 2003
    ..g., by using the membership mailing list to the Association for Ethnic Diversity in the Neurosciences). ..
  2. NEURONAL DEATH AND SURVIVAL
    Ronald Oppenheim; Fiscal Year: 2003
    ....
  3. Neuromuscular Activity: Development and Survival of Avian and Mammalian Neurons
    Ronald W Oppenheim; Fiscal Year: 2010
    ..abstract_text> ..
  4. Motor System Development in the Absence of Cell Death
    Ronald Oppenheim; Fiscal Year: 2007
    ..abstract_text> ..
  5. DEVELOPMENT AND SURVIVAL OF GLIAL CELLS
    Ronald Oppenheim; Fiscal Year: 2001
    ....
  6. Vascular inflammation and neurotoxicity in aging brain
    Paula Grammas; Fiscal Year: 2009
    ....
  7. The Role of Id2 in Adult Neurogenesis
    MATTHEW HAVRDA; Fiscal Year: 2008
    ..These experiments are immediately relevant to realization of the therapeutic potential of these unique cells. [unreadable] [unreadable]..
  8. Regulation of PTEN-induced kinase 1 (PINK 1)
    Charleen Chu; Fiscal Year: 2007
    ..In addition, a group of immunochemical and molecular reagents will have been created that can facilitate the work of other investigators studying mechanisms of Parkinson's and related diseases. [unreadable] [unreadable]..
  9. Training in proteomics of novel kinase substrates for neurodegeneration
    Charleen Chu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  10. The function of Foxi3 in craniofacial development
    Takahiro Ohyama; Fiscal Year: 2008
    ..This project has significant potential for the future study of craniofacial and sensory organ development that will shed a light on the genetic mechanisms of craniofacial birth defects. ..
  11. Leptin Signaling in Cardiac Hypertrophy
    LILI BAROUCH; Fiscal Year: 2008
    ..Barouch will launch a successful career as an independent physician-scientist. ..
  12. CHONDROGENESIS AND HISTONE MODIFICATION ENZYMES
    Liu Yang; Fiscal Year: 2007
    ....
  13. The role of HNF4 in gastrointestinal development
    Michele Battle; Fiscal Year: 2006
    ..By understanding how this transcription factor functions in the gut, greater insight into the fundamental molecular processes underlying gut development wilt be gained. ..
  14. Investigating the Role of Tbx1 in Ear Development
    Evan Braunstein; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Metabolomics: From Bioenergetics To Apoptosis
    Craig Thompson; Fiscal Year: 2005
    ..Understanding the relationships between metabolism and apoptosis may lead to novel approaches for the prevention and/or treatment of cancer and degenerative disorders. ..
  16. Proteomics of altered protein in macular degeneration
    DEBORAH FERRINGTON; Fiscal Year: 2006
    ..Identification of proteins that are uniquely altered will help provide valuable insight into the mechanism of AMD. ..
  17. Gene Therapy of Muscle Wasting From Uremia
    Xiaonan Wang; Fiscal Year: 2005
    ..We believe that the experimental results will shed the insight on the mechanisms of muscle protein degradation, and provide a possible new approach to treat the pathological process of muscle wasting. ..
  18. Notch Signaling in Olfactory Progenitor Cell Fate
    TIMOTHY HENION; Fiscal Year: 2004
    ..The results obtained from these preliminary studies will provide important information on the mechanisms which regulate cell diversity in the olfactory system, and potentially other neurogenic tissues. ..
  19. CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL APOPTOSIS
    Irina Petrache; Fiscal Year: 2004
    ..abstract_text> ..
  20. Lymphocyte Survival: Implications for lymphomagenesis
    Craig B Thompson; Fiscal Year: 2010
    ....
  21. THE PARKINSONIAN 6 HYDROXYDOPAMINE MODEL
    Charleen Chu; Fiscal Year: 2004
    ....
  22. Mutagenesis of Tbx3: a model of ulnar-mammary syndrome
    Anne M Moon; Fiscal Year: 2010
    ..The flexible model system we propose will be a valuable tool for developmental studies of many organs and lead to a deeper understanding of the genetic and molecular bases of congenital anomalies in humans. ..
  23. Is There a Link Between Alzheimer's and Atheroclerosis
    Paula Grammas; Fiscal Year: 2007
    ..abstract_text> ..
  24. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2005
    ..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
  25. Non-apoptotic role of caspase 3 in endosomal remodeling
    Laura Santambrogio; Fiscal Year: 2007
    In immature bone marrow derived dendritic cells (BMDC) caspase 3 acting in a non-apoptotic pathway controls the processing of molecules required for endosomal remodeling into tubular structures...
  26. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2007
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
  27. CELLULAR INTERACTIONS IN PULMONARY OXYGEN TOXICITY
    ANBUKILI CHETTY; Fiscal Year: 2006
    ..This mentored work will provide extensive education and technical experience in Molecular Biology and the development of a model of hyperoxic lung injury. ..
  28. EMPTY CLASS II MHC PROTEINS: TRAFFICKING AND FUNCTION
    Laura Santambrogio; Fiscal Year: 2005
    ..The proposed research is part of an interactive research project grant. The companion project will focus on the biochemical aspects of antigen processing and peptide loading as part of the characterization of this novel pathway. ..
  29. BHLH FACTOR IN DIABETES & PANCREAS DEVELOPMENT
    DEBRA BRAMBLETT; Fiscal Year: 2003
    ..The BETA4 knockout will be a mouse model system for the study of aspects of pancreas development and possibly pancreatic disease. ..
  30. Proteasome function in the aging retina
    Deborah A Ferrington; Fiscal Year: 2010
    ..Results from these experiments will help verify that immunoproteasome is an essential component of the retinal stress response and plays a fundamental role in maintaining retinal health. ..
  31. CONDITIONAL MUTAGENESIS OF FIBROBLAST GROWTH FACTORS
    Anne Moon; Fiscal Year: 2002
    ..Ultimately, this knowledge will help us to understand how alterations in those pathways, whether genetic or environmental, result in congenital malformations in infants and children. ..