Genomes and Genes
Gene Symbol: Casp3
Description: caspase 3
Alias: A830040C14Rik, AC-3, CASP-3, CC3, CPP-32, CPP32, Caspase-3, Lice, SCA-1, Yama, mldy, caspase-3, SREBP cleavage activity 1, apopain, caspase 3, apoptosis related cysteine protease, cysteine protease CPP32, protein Yama
Publications214 found, 100 shown here
- Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteumSilvia F Carambula
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 143:1495-501. 2002..However, caspase-3 is not a direct mediator of the decrease in steroidogenesis associated with luteolysis...
- Calcium-induced calpain mediates apoptosis via caspase-3 in a mouse photoreceptor cell lineAshish K Sharma
Department of Ophthalmology, Storm Eye Institute, University of South Carolina, Charleston 29425, USA
J Biol Chem 279:35564-72. 2004..We concluded that Ca(2+) influx in the rd model of photoreceptor degeneration leads to the activation of the cysteine protease calpain, which executes apoptosis via modulation of caspase-3 activity...
- Selective up-regulation of caspase-3 gene expression following TCR engagementLaurent Sabbagh
Laboratoire d Immunologie, Centre de Recherche du CHUM, Campus St Luc, Pavillon Edouard Asselin, 264 Boul Rene Levesque Est 1307D, Montreal, Que, Canada H2X 1P1
Mol Immunol 42:1345-54. 2005..Together, these results show that TCR activation triggers the selective increase in caspase-3 mRNA levels, independently of caspase activity and the induction of apoptosis...
- Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changesM Woo
Amgen Institute Ontario Cancer Institute, Department of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5G2C1, Canada
Genes Dev 12:806-19. 1998..CPP32 (caspase 3) is a prototypical caspase that becomes activated during apoptosis...
- Executioner caspase-3 and caspase-7 are functionally distinct proteasesJohn G Walsh
Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
Proc Natl Acad Sci U S A 105:12815-9. 2008..Our observations provide a molecular basis for the different phenotypes seen in mice lacking either caspase and indicate that these proteases occupy nonredundant roles within the cell death machinery...
- The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2Konstantin Gaengel
Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
Dev Cell 23:587-99. 2012..Our data suggest that S1PR1 signaling acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses...
- Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 proteinHirotaka Kazama
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 631101, USA
Immunity 29:21-32. 2008..Similarly, blocking sites of oxidation in HMGB1 prevented tolerance induction by apoptotic cells. These results suggest that caspase-orchestrated mitochondrial events determine the impact of apoptotic cells on the immune response...
- Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3βJihoon Jo
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
Nat Neurosci 14:545-7. 2011..We found that a signaling pathway involving caspase-3, Akt1 and glycogen synthase kinase-3β is an important mediator of this effect in rats and mice...
- Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activationJames E Vince
Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
Immunity 36:215-27. 2012....
- Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulbSusan J Harrison
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Cereb Cortex 18:1604-17. 2008..In Sall1-mutant animals, these patterns of neurogenesis were disrupted. These findings suggest a role for Sall1 in regulating neuronal differentiation and maturation in developing neural structures...
- The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturationSayan Nandi
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
Dev Biol 367:100-13. 2012..Thus our results also indicate novel roles for the CSF-1R in the regulation of corticogenesis...
- Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasionChiara Rigato
Institut National de la Sante et de la Recherche Medicale, U952, Universite Pierre et Marie Curie, Paris, Ile de France, France
J Neurosci 32:11559-73. 2012..These results reveal a developmental role of P2X7R by controlling embryonic SC microglia proliferation at a critical developmental state in the SC of mouse embryos...
- Decreased apoptosis in the brain and premature lethality in CPP32-deficient miceK Kuida
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Nature 384:368-72. 1996..Among the ten or more members of the ICE protease family, CPP32/yama/apopain exhibits the highest similarity to CED-3 in both sequence homology and substrate specificity...
- Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's diseaseV Viswanath
Buck Institute for Age Research, Novato, California 94945, USA
J Neurosci 21:9519-28. 2001..These data suggest that caspase inhibitors constitute a plausible therapeutic for PD...
- Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammalsZohar Schoenmann
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
J Neurosci 30:6375-86. 2010..These findings indicate that two distinct autodestruction pathways act separately or in concert to regulate developmental neurite pruning...
- Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortexLilla M Farkas
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
Neuron 60:40-55. 2008..Our data imply that Insm1 is involved in the generation and expansion of basal progenitors, a hallmark of neocortex evolution...
- Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth developmentJianquan Chen
Department of Biology, University of Rochester, Rochester, New York 14642, USA
Dev Biol 334:174-85. 2009..Together, these results indicate that activation of the mesenchymal odontogenic program during early tooth development requires concerted actions of Bmp, Fgf and Wnt signaling from the presumptive dental epithelium to the mesenchyme...
- Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital developmentQingru Wang
Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
Dev Biol 288:582-94. 2005..These data provide new insights into the molecular mechanisms underlying heart morphogenesis and urogenital development...
- Overexpression of thioredoxin-1 reduces oxidative stress in the placenta of transgenic mice and promotes fetal growth via glucose metabolismTakashi Umekawa
Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
Endocrinology 149:3980-8. 2008..In particular, increased hTRX-1 activity and the resulting modified placental redox state may play an important role in fetal growth by increasing the availability of glucose...
- Caveolin-1-dependent apoptosis induced by fibrin degradation productsYi He Guo
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226 3548, USA
Blood 113:4431-9. 2009....
- Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activityShizue Ohsawa
Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
Proc Natl Acad Sci U S A 107:13366-71. 2010..Our findings suggest that Apaf-1/caspase-9-mediated nonapoptotic caspase signaling is required for the proper neural network formation during olfactory development...
- Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survivalKen ichiro Kuwako
Institute for Protein Research, Osaka University, Osaka 565 0871, Japan
J Neurosci 25:7090-9. 2005..These results suggest that paternally expressed necdin facilitates TrkA signaling to promote the survival of NGF-dependent nociceptive neurons...
- Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesisLizhu Lin
Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Dev Biol 295:756-63. 2006..We find that expression of npn2 is downregulated in isl1-cre;smo mutants, suggesting an isl1/Shh/npn pathway required to affect morphogenesis at the anterior pole of the heart...
- Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signalingHelen A Thomason
Faculty of Medical and Human Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, England, UK
Dev Biol 321:273-82. 2008..Our results are consistent with a role for Tp63 in the regulation of Bmp signaling controlling the growth, modelling and fusion events underlying facial development and shed new light on the complex abnormality of facial clefting...
- Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICES Wang
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 92:501-9. 1998..Our data suggest that caspase-11 is a component of ICE complex and is required for the activation of ICE...
- Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activationJui Hung Yen
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
Blood 114:1344-54. 2009....
- Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic heartsLanying Song
Division of Genetic and Translational Medicine, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Dev Biol 301:276-86. 2007..Taken together, our study supports the notion that Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis...
- High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchymaDavid S Hains
Division of Nephrology, Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio, USA
J Urol 183:2077-84. 2010..We determined whether Fgfr2(Mes-/-) mutants developed abnormally positioned ureters predisposing to vesicoureteral reflux...
- A role for FE65 in controlling GnRH-1 neurogenesisPaolo E Forni
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 31:480-91. 2011....
- Detection of activated caspase-3 (CPP32) in the vertebrate nervous system during development by a cleavage site-directed antiserumK Urase
Division of Development and Differentiation, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
Brain Res Dev Brain Res 111:77-87. 1998..Mukasa, K. Urase, Y.M. Momoi, I. Kimura, T. Momoi, Specific expression of CPP32 in sensory neurons of mouse embryos and activation of CPP32 in the apoptosis induced by a withdrawal of NGF, ..
- F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosisS L Chan
Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Republic of Singapore
J Biol Chem 274:32461-8. 1999..F1Aalpha is therefore a member of a growing family of death receptor-associated proteins that mediates apoptosis...
- Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retinaLiang Feng
Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
Development 133:4815-25. 2006..Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes...
- Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagyRonald W Oppenheim
Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Neurosci 28:1490-7. 2008..e., caspases and Apaf-1) are perturbed in vivo, developing postmitotic neurons nonetheless undergo quantitatively normal PCD by a caspase-independent pathway involving autophagy and not requiring AIF...
- Mouse vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetesC Roisin-Bouffay
Aix Marseille Universite, Faculte des Sciences de Luminy, Centre d immunologie de Marseille Luminy, Marseille, France
Diabetologia 51:1192-201. 2008..The epithelial pantetheinase vanin-1 is proinflammatory and cytoprotective via cysteamine release in some tissues. We investigated the impact of a vanin-1 deficiency on islet death and type 1 diabetes incidence...
- Apaf-1-independent programmed cell death in mouse developmentA Nagasaka
Department of Medical Chemistry, Kyoto University, Yoshida Konoe, Sakyo ku, Japan
Cell Death Differ 17:931-41. 2010..Thus, programmed cell death in mouse development, which normally proceeds in an efficient Apaf-1-depenent mechanism, appears to be backed up by Apaf-1-independent death systems...
- Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesotheliomaSharyn I Katz
Laboratory of Molecular Oncology and Cell Cycle Regulation, Department of Medicine Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Cancer Biol Ther 8:2406-16. 2009..We document single agent activity of sorafenib against MPM, unravel novel effects of sorafenib on anti-apoptotic signaling mediators, and suggest the combination of sorafenib plus TRAIL as possible therapy for clinical testing in MPM...
- Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lungAhmed H K El-Hashash
Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA
Dev Biol 350:112-26. 2011..We conclude, therefore, that Eya1 function is critical for proper coordination of lung epithelial, mesenchymal and vascular development...
- Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve developmentVesna Todorovic
Department of Cell Biology, NYU Langone Medical Center, New York, New York 10016, USA
Dev Dyn 240:176-87. 2011..We demonstrate that Ltbp1L is a major regulator of Tgf-β activity during valvulogenesis since its absence results in a perturbed Tgf-β pathway that causes all Ltbp1L(-/-) valvular defects...
- α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in miceAmparo Girós
Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Burjassot, Spain
PLoS ONE 6:e22002. 2011..Thus, α5β1-mediated adhesion to FN in the PSM regulates the dynamics of membrane protrusions and cell-to-cell communication essential for elongation and segmentation of the body axis...
- Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochleaTakayuki Okano
Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland 20892, USA
J Neurosci 31:18104-18. 2011..The results also provide new insights regarding the pathological processes that underlie auditory defects in the absence of IGF signaling in both humans and mice...
- Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterningDeanna G Wilson
Genentech, South San Francisco, CA 94080, USA
Dev Biol 363:413-25. 2012..Our results place Chsy1 as an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1...
- Loss of the Prader-Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neuronsAlysa A Tennese
Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada
Dev Dyn 237:1935-43. 2008..Furthermore, reduced sympathetic function provides a plausible explanation for deficiencies of salivary gland function in individuals with congenital necdin deficiency consequent to Prader-Willi syndrome...
- Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrainJohn Jacob
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 136:2477-85. 2009..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations...
- A novel transient glutamatergic population migrating from the pallial-subpallial boundary contributes to neocortical developmentAnne Teissier
Centre National de la Recherche Scientifique Unité Mixte de Recherche 7592, Institut Jacques Monod, Universite Paris Diderot, 75205 Paris Cedex 13, France
J Neurosci 30:10563-74. 2010....
- Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodelingVesna Todorovic
Cell Biology Department, NYU School of Medicine, New York, NY 10016, USA
Development 134:3723-32. 2007..This phenotype reveals a crucial role for Ltbp1L and matrix as extracellular regulators of Tgf-beta activity in heart organogenesis...
- ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cellsLing Pan
Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA
Development 135:1981-90. 2008..Thus, our results uncover a novel regulatory mechanism of BRN3B and ISL1 in RGC differentiation...
- Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cellsIrene Puga
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Immunity 29:193-204. 2008..Casp3 is one of the genes activated during anergy induction. Here we show that caspase 3 is required for the induction of T cell unresponsiveness...
- CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzymeT Fernandes-Alnemri
Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
J Biol Chem 269:30761-4. 1994..The new gene encodes a 32-kDa putative cysteine protease (CPP32) with significant homology to Caenorhabditis elegans cell death protein Ced-3, mammalian interleukin-1 beta-..
- Akt negatively regulates translation of the ternary complex factor Elk-1Claudia Figueroa
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 0606, USA
Oncogene 22:5554-61. 2003..We conclude that Akt negatively regulates translation of the Elk-1 mRNA. A coding region determinant that maps within the first 279 nts of the Elk-1 message is necessary and sufficient for Akt-mediated regulation of Elk-1...
- Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosisJiang Chang
Center for Molecular Development and Disease, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:14495-500. 2006..These data suggest an obligatory role for ROCK-1 cleavage in promoting apoptotic signals in myocardial hypertrophy and/or failure...
- BARHL2 differentially regulates the development of retinal amacrine and ganglion neuronsQian Ding
University of Rochester Eye Institute, University of Rochester, Rochester, New York 14642, USA
J Neurosci 29:3992-4003. 2009..Thus, BARHL2 appears to have numerous roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival...
- In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous systemA Srinivasan
Idun Pharmaceuticals, Inc, La Jolla, California 92037, USA
Cell Death Differ 5:1004-16. 1998..These studies indicate that caspase-3 is activated during apoptosis in the developing nervous system in vivo and that CM1 is a useful reagent for its in situ detection...
- Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing lossK Takahashi
Department of Otolaryngology Head and Neck Surgery, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi gun, 329 0498, Tochigi, Japan
Brain Res 894:359-67. 2001....
- Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovaryT Matikainen
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston 02114, USA
Endocrinology 142:2468-80. 2001..We conclude that caspase-3 is functionally required for granulosa cell apoptosis during follicular atresia, but that the enzyme is dispensable for germ cell apoptosis in the female...
- Math5 is required for retinal ganglion cell and optic nerve formationN L Brown
Departments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109 0650, USA
Development 128:2497-508. 2001..A small number of nascent RGCs are detected during embryogenesis, but these fail to develop further, suggesting that committed RGCs may also require Math5 function...
- Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retinaXiuqian Mu
Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Curr Biol 15:525-30. 2005..Intrinsic rather than extrinsic factors are likely to play the critical roles in determining retinal cell fate...
- Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromesAnne M Moon
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
Dev Cell 10:71-80. 2006..These findings provide mechanistic insight into disrupted intercellular interactions in the pathogenesis of malformations seen in del22q11 syndrome...
- Retinoblastoma family proteins: insights gained through genetic manipulation of miceK A Wikenheiser-Brokamp
Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Ohio, 45267 0529, USA
Cell Mol Life Sci 63:767-80. 2006..This review summarizes the phenotypic consequences of Rb family ablation in mice, and discusses how these findings contribute to the increasingly complex picture of Rb family function in development and tumor suppression...
- alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathwayWen Hui Lien
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Science 311:1609-12. 2006..We propose that alphaE-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex...
- UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1Megan E Williams
Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
Nat Neurosci 9:996-8. 2006..In contrast, loss of netrin-1 (Ntn1) did not affect the amount of apoptosis, suggesting that NTN1 is not required for neuronal apoptosis in vivo...
- Canonical notch signaling functions as a commitment switch in the epidermal lineageCedric Blanpain
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Genes Dev 20:3022-35. 2006....
- The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusionMargaret E McLaughlin
Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 104:3261-6. 2007..Our work reveals that regulation of Nf2 expression is a previously unrecognized means of controlling adhesion at the leading front, thereby ensuring successful tissue fusion...
- Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functionsKelly A McClellan
Department of Cellular and Molecular Medicine, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada
Mol Cell Biol 27:4825-43. 2007..This study not only outlines overlapping and distinct functions for E2Fs in neurogenesis but also is the first to establish a physiologically relevant role for the Rb/E2F pathway beyond cell cycle regulation in vivo...
- Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotypeVladimir N Simirskii
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Dev Biol 306:658-68. 2007..Thus, beta1-integrin is required to maintain the lens epithelial phenotype and block inappropriate activation of some aspects of the lens fiber cell differentiation program...
- Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systemsMerritt K Taylor
Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109 2216, USA
Development 134:2435-47. 2007..These results demonstrate that physiological Notch signaling is required for gliogenesis in vivo, independent of the role of Notch in the maintenance of undifferentiated neural progenitors...
- In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochleaHuansheng Xu
Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030, USA
Dev Biol 310:329-40. 2007..This model provides a striking demonstration of the essential role played by the periotic mesenchyme in the organogenesis of the cochlea...
- Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zoneBeatriz Cubelos
Centro Nacional de Biotecnologia, CSIC, Darwin 3, Campus de Cantoblanco, Madrid 28049, Spain
Cereb Cortex 18:1758-70. 2008..Our results point to Cux-2 as a key element in the control of the proliferation rates of the SVZ precursors and the number of upper cortical neurons, without altering the number of deep cortical layers...
- The role of IL-6 and IL-11 in hyperoxic injury in developing lungAnne Chetty
Department of Pediatrics, Floating Hospital for Children, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Pediatr Pulmonol 43:297-304. 2008..IL-11 and IL-6 provide protective effects against oxidant-mediated injury in fetal type II cells and IL-11 provides protection in vivo by down-regulation of caspase-mediated cell death...
- Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cellsMarion Dejosez
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
Cell 133:1162-74. 2008..Our findings identify Ronin as an essential factor underlying embryogenesis and ES cell pluripotency. Its association with HCF-1 suggests an epigenetic mechanism of gene repression in pluripotent cells...
- Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive functionIVY S SAMUELS
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106 4928, USA
J Neurosci 28:6983-95. 2008..These findings demonstrate an important role for ERK2 in cellular proliferation and differentiation during neural development as well as in cognition and memory formation...
- Requirement for Lmo4 in the vestibular morphogenesis of mouse inner earMin Deng
University of Rochester Flaum Eye Institute, University of Rochester, Rochester, NY 14642, USA
Dev Biol 338:38-49. 2010....
- Characterization of seven murine caspase family membersM Van de Craen
Flanders Interuniversity Institute for Biotechnology and University of Ghent, Belgium
FEBS Lett 403:61-9. 1997..were cloned and functionally characterized by transient overexpression: mCASP-1 (mICE), mCASP-2 (Ich1), mCASP-3 (CPP32), mCASP-6 (Mch2), mCASP-7 (Mch3), mCASP-11 (TX) and mCASP-12...
- Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9K Kuida
Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139, USA
Cell 94:325-37. 1998..Casp9 deletion prevents activation of Casp3 in embryonic brains in vivo, and Casp9-deficient thymocytes show resistance to a subset of apoptotic stimuli, ..
- Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian developmentF Cecconi
Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
Cell 94:727-37. 1998..elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of CASP3 in the general apoptotic pathway. We have generated by gene trap a null allele of the murine Apaf1...
- Defective neurogenesis resulting from DNA ligase IV deficiency requires AtmY Lee
Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Genes Dev 14:2576-80. 2000..Therefore, ATM could be important for preventing accumulation of DNA-damaged cells in the nervous system that might eventually lead to the neurodegeneration observed in ataxia telangiectasia...
- Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant miceM C Vemuri
Program in Neuroscience and Behavior, Department of Biology, Wesleyan University, Middletown, CT 06457, USA
Cell Death Differ 8:245-55. 2001..Additional biochemical and immunocytochemical studies indicated that of several DNA repair enzymes investigated, only PARP was increased in scid mice, possibly in response to elevated DNA strand breaks...
- Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient miceJeffrey R Leonard
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neuropathol Exp Neurol 61:673-7. 2002....
- Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland developmentAkihiro Nishida
Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
Nat Neurosci 6:1255-63. 2003..Thus, Otx2 is a key regulatory gene for the cell fate determination of retinal photoreceptor cells. Our results reveal the key molecular steps required for photoreceptor cell-fate determination and pinealocyte development...
- High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanismRyuhei Okuyama
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Dev Cell 6:551-62. 2004..promotes keratinocyte differentiation, is upregulated in embryonic keratinocyte and epidermis, and elevated caspase 3 expression, which we identify as a transcriptional Notch1 target, accounts in part for the high commitment of ..
- The transcription factor Bhlhb4 is required for rod bipolar cell maturationDebra E Bramblett
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 43:779-93. 2004..Other retinal cell populations including photoreceptors were unaltered. The timing of RB cell depletion in the Bhlhb4(-/-) mouse suggests that Bhlhb4 is essential for RB cell maturation...
- A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cellsMasako Miura
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research NIDCR, NIH, Bethesda, MD 20892, USA
J Clin Invest 114:1704-13. 2004..Here we report delayed ossification and decreased bone mineral density in caspase-3-deficient (Casp3(-/-) and Casp3(+/-)) mice due to an attenuated osteogenic differentiation of bone marrow stromal stem cells (..
- Neural stem cell differentiation is dependent upon endogenous caspase 3 activityPasan Fernando
Ottawa Health Research Institute, Molecular Medicine Program, Ottawa, Ontario, Canada
FASEB J 19:1671-3. 2005..These results implicate caspase-3 activation as a conserved feature of neuronal differentiation and suggest that targeted inhibition of this protease in neural cell populations may have unintended consequences...
- Caspases 3 and 7: key mediators of mitochondrial events of apoptosisSaquib A Lakhani
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Science 311:847-51. 2006..We generated mice deficient in the two effectors, caspase 3 and caspase 7, which died immediately after birth with defects in cardiac development...
- SOX2 is a dose-dependent regulator of retinal neural progenitor competenceOlena V Taranova
Department of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA
Genes Dev 20:1187-202. 2006....
- Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell deathDavid Andrieu
Institut de Biologie du Developpement de Marseille Luminy, Campus de Luminy Case 907 13288 Marseille Cedex 09, France
BMC Dev Biol 6:56. 2006..In this study, we investigate sensory-motor behaviour in Necdin deficient mice. We reveal cellular defects and analyse their cause...
- BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanismsArnaud A Mailleux
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Dev Cell 12:221-34. 2007..These data provide important mechanistic information on the processes involved in sculpting the mammary gland and demonstrate that BIM is a critical regulator of apoptosis in vivo...
- Human and murine granzyme B exhibit divergent substrate preferencesSean P Cullen
Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
J Cell Biol 176:435-44. 2007..These data demonstrate that human and murine GzmB are distinct enzymes with different substrate preferences. Our observations also illustrate how subtle differences in enzyme structure can radically affect substrate selection...
- Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesisAlice T Shaw
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston 02114, USA
Genes Dev 21:694-707. 2007..These findings indicate that in the lung, Sprouty-2 plays a critical role in the regulation of oncogenic K-ras, and implicate counter-regulatory mechanisms in the pathogenesis of Ras-based disease...
- LKB1 and SAD kinases define a pathway required for the polarization of cortical neuronsAnthony P Barnes
Neuroscience Center, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
Cell 129:549-63. 2007..Thus, we provide evidence in vivo and in vitro for a multikinase pathway that links extracellular signals to the intracellular machinery required for axon specification...
- Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and developmentTamara Terzian
Department of Cancer Genetics, Box 1010, The University of Texas M D Anderson Cancer Center, Baylor College of Medicine, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Cell Biol 27:5479-85. 2007..These findings highlight the exquisite sensitivity of p53 to Mdm2 and Mdm4 levels and suggest that some cell types may be more sensitive to therapeutic drugs that inhibit the Mdm-p53 interaction...
- The RGD motif in fibronectin is essential for development but dispensable for fibril assemblySeiichiro Takahashi
Max Planck Institute of Biochemistry, Department of Molecular Medicine, 82152 Martinsried, Germany
J Cell Biol 178:167-78. 2007..Our findings demonstrate that FN contains a novel motif for integrin binding and fibril formation whose activity is controlled by amino acid modification...
- Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2Wenlai Zhou
Howard Hughes Medical Institute and Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Nat Genet 39:1225-34. 2007..Thus, we propose that transcriptional readout mediated at least in part by a Wnt11 --> ATF/CREB --> TGFbeta2 pathway is critical in regulating morphogenesis in response to noncanonical Wnt signaling...
- N-myc coordinates retinal growth with eye size during mouse developmentRodrigo A P Martins
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Genes Dev 22:179-93. 2008..We propose that N-myc lies upstream of the cell cycle machinery in the developing mouse retina and thus coordinates the growth of both the retina and eye through extrinsic cues...
- Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formationEvan M Braunstein
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
J Assoc Res Otolaryngol 9:33-43. 2008....
- Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiationMatthew J Hilton
Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Nat Med 14:306-14. 2008..Thus, mesenchymal progenitors may be expanded in vitro by activating the Notch pathway, whereas bone formation in vivo may be enhanced by transiently suppressing this pathway...
- Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cellsTatsuya Katsuno
Laboratory of Biological Science, Graduate School of Frontier Biosciences, and Graduate School of Medicine, Osaka University, Japan
Mol Biol Cell 19:2465-75. 2008..In conclusion, ZO-1 may be functionally important for cell remodeling and tissue organization in both the embryonic and extraembryonic regions, thus playing an essential role in embryonic development...
- Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulationNicholas Warr
Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, UK
Hum Mol Genet 17:2986-96. 2008..The analysis provides genetic evidence that Zic2 functions during organizer formation and that the PCP develops via a multi-step process...
- NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivoM J M Bertrand
URPHYM Unité de Recherches en Physiologie Moléculaire, FUNDP School of Medicine, University of Namur, Namur, Belgium
Cell Death Differ 15:1921-9. 2008..Together, these studies demonstrate that NRAGE plays an important role in apoptotic-signaling in vivo...
- A non-apoptotic role for caspase-9 in muscle differentiationThomas V A Murray
National Centre for Biomedical Engineering Science and Department of Pharmacology and Therapeutics, National University of Ireland, Galway, Ireland
J Cell Sci 121:3786-93. 2008....
- Specific glial populations regulate hippocampal morphogenesisGuy Barry
The University of Queensland, Queensland Brain Institute, and School of Biomedical Sciences, Brisbane, 4067, Australia
J Neurosci 28:12328-40. 2008..These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis...
- Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBSErin R P Shull
Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Genes Dev 23:171-80. 2009..Thus, DNA damage signaling in the nervous system is different between ATLD and NBS and likely explains their respective neuropathology...
- Ontogeny of Motor Systems: Neurogenesis to BehaviorRonald Oppenheim; Fiscal Year: 2003..g., by using the membership mailing list to the Association for Ethnic Diversity in the Neurosciences). ..
- NEURONAL DEATH AND SURVIVALRonald Oppenheim; Fiscal Year: 2003....
- Neuromuscular Activity: Development and Survival of Avian and Mammalian NeuronsRonald W Oppenheim; Fiscal Year: 2010..abstract_text> ..
- Motor System Development in the Absence of Cell DeathRonald Oppenheim; Fiscal Year: 2007..abstract_text> ..
- DEVELOPMENT AND SURVIVAL OF GLIAL CELLSRonald Oppenheim; Fiscal Year: 2001....
- Vascular inflammation and neurotoxicity in aging brainPaula Grammas; Fiscal Year: 2009....
- The Role of Id2 in Adult NeurogenesisMATTHEW HAVRDA; Fiscal Year: 2008..These experiments are immediately relevant to realization of the therapeutic potential of these unique cells. [unreadable] [unreadable]..
- Regulation of PTEN-induced kinase 1 (PINK 1)Charleen Chu; Fiscal Year: 2007..In addition, a group of immunochemical and molecular reagents will have been created that can facilitate the work of other investigators studying mechanisms of Parkinson's and related diseases. [unreadable] [unreadable]..
- Training in proteomics of novel kinase substrates for neurodegenerationCharleen Chu; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- The function of Foxi3 in craniofacial developmentTakahiro Ohyama; Fiscal Year: 2008..This project has significant potential for the future study of craniofacial and sensory organ development that will shed a light on the genetic mechanisms of craniofacial birth defects. ..
- Leptin Signaling in Cardiac HypertrophyLILI BAROUCH; Fiscal Year: 2008..Barouch will launch a successful career as an independent physician-scientist. ..
- CHONDROGENESIS AND HISTONE MODIFICATION ENZYMESLiu Yang; Fiscal Year: 2007....
- The role of HNF4 in gastrointestinal developmentMichele Battle; Fiscal Year: 2006..By understanding how this transcription factor functions in the gut, greater insight into the fundamental molecular processes underlying gut development wilt be gained. ..
- Investigating the Role of Tbx1 in Ear DevelopmentEvan Braunstein; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Metabolomics: From Bioenergetics To ApoptosisCraig Thompson; Fiscal Year: 2005..Understanding the relationships between metabolism and apoptosis may lead to novel approaches for the prevention and/or treatment of cancer and degenerative disorders. ..
- Proteomics of altered protein in macular degenerationDEBORAH FERRINGTON; Fiscal Year: 2006..Identification of proteins that are uniquely altered will help provide valuable insight into the mechanism of AMD. ..
- Gene Therapy of Muscle Wasting From UremiaXiaonan Wang; Fiscal Year: 2005..We believe that the experimental results will shed the insight on the mechanisms of muscle protein degradation, and provide a possible new approach to treat the pathological process of muscle wasting. ..
- Notch Signaling in Olfactory Progenitor Cell FateTIMOTHY HENION; Fiscal Year: 2004..The results obtained from these preliminary studies will provide important information on the mechanisms which regulate cell diversity in the olfactory system, and potentially other neurogenic tissues. ..
- CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL APOPTOSISIrina Petrache; Fiscal Year: 2004..abstract_text> ..
- Lymphocyte Survival: Implications for lymphomagenesisCraig B Thompson; Fiscal Year: 2010....
- THE PARKINSONIAN 6 HYDROXYDOPAMINE MODELCharleen Chu; Fiscal Year: 2004....
- Mutagenesis of Tbx3: a model of ulnar-mammary syndromeAnne M Moon; Fiscal Year: 2010..The flexible model system we propose will be a valuable tool for developmental studies of many organs and lead to a deeper understanding of the genetic and molecular bases of congenital anomalies in humans. ..
- Is There a Link Between Alzheimer's and AtheroclerosisPaula Grammas; Fiscal Year: 2007..abstract_text> ..
- TLS and TLS Fusion Proteins in LeukemiaLiu Yang; Fiscal Year: 2005..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
- Non-apoptotic role of caspase 3 in endosomal remodelingLaura Santambrogio; Fiscal Year: 2007In immature bone marrow derived dendritic cells (BMDC) caspase 3 acting in a non-apoptotic pathway controls the processing of molecules required for endosomal remodeling into tubular structures...
- MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICECaroline Zeiss; Fiscal Year: 2007..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
- CELLULAR INTERACTIONS IN PULMONARY OXYGEN TOXICITYANBUKILI CHETTY; Fiscal Year: 2006..This mentored work will provide extensive education and technical experience in Molecular Biology and the development of a model of hyperoxic lung injury. ..
- EMPTY CLASS II MHC PROTEINS: TRAFFICKING AND FUNCTIONLaura Santambrogio; Fiscal Year: 2005..The proposed research is part of an interactive research project grant. The companion project will focus on the biochemical aspects of antigen processing and peptide loading as part of the characterization of this novel pathway. ..
- BHLH FACTOR IN DIABETES & PANCREAS DEVELOPMENTDEBRA BRAMBLETT; Fiscal Year: 2003..The BETA4 knockout will be a mouse model system for the study of aspects of pancreas development and possibly pancreatic disease. ..
- Proteasome function in the aging retinaDeborah A Ferrington; Fiscal Year: 2010..Results from these experiments will help verify that immunoproteasome is an essential component of the retinal stress response and plays a fundamental role in maintaining retinal health. ..
- CONDITIONAL MUTAGENESIS OF FIBROBLAST GROWTH FACTORSAnne Moon; Fiscal Year: 2002..Ultimately, this knowledge will help us to understand how alterations in those pathways, whether genetic or environmental, result in congenital malformations in infants and children. ..