Casp1

Summary

Gene Symbol: Casp1
Description: caspase 1
Alias: ICE, Il1bc, caspase-1, CASP-1, IL-1 beta-converting enzyme, IL-1B converting enzyme, IL-1BC, interleukin-1 beta convertase, interleukin-1 beta-converting enzyme, p45
Species: mouse

Top Publications

  1. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
  2. ncbi Gout-associated uric acid crystals activate the NALP3 inflammasome
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 440:237-41. 2006
  3. ncbi Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 430:213-8. 2004
  4. pmc Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington, USA
    Nat Immunol 11:1136-42. 2010
  5. pmc Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing
    Petr Broz
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Cell Host Microbe 8:471-83. 2010
  6. doi Active caspase-1 is a regulator of unconventional protein secretion
    Martin Keller
    Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 132:818-31. 2008
  7. doi The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    Daniel A Muruve
    Department of Medicine, University of Calgary, Alberta T2N 4N1, Canada
    Nature 452:103-7. 2008
  8. pmc Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
    Susan L Fink
    Molecular and Cellular Biology Program, Departments of Microbiology and Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:4312-7. 2008
  9. doi Superoxide dismutase 1 regulates caspase-1 and endotoxic shock
    Felix Meissner
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
    Nat Immunol 9:866-72. 2008
  10. pmc Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
    Jonathan W Jones
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:9771-6. 2010

Research Grants

  1. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
  2. CARDIAC LESIONS IN HIV1 TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2001
  3. CHEMOKINES IN LUNG DISEASE OF HIV1 TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2003
  4. STUDIES OF LUNG DISEASES OF HIV TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2009
  5. Modulation of Host Cell Functions by Coxiella burnetii
    Craig R Roy; Fiscal Year: 2010
  6. PROTEIN PROFILING OF ORAL MUCOSA OF HIV TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications171 found, 100 shown here

  1. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
    ..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
  2. ncbi Gout-associated uric acid crystals activate the NALP3 inflammasome
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 440:237-41. 2006
    ..These findings provide insight into the molecular processes underlying the inflammatory conditions of gout and pseudogout, and further support a pivotal role of the inflammasome in several autoinflammatory diseases...
  3. ncbi Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 430:213-8. 2004
    ..Notably, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways...
  4. pmc Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington, USA
    Nat Immunol 11:1136-42. 2010
    ..This demonstrates that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system...
  5. pmc Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing
    Petr Broz
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Cell Host Microbe 8:471-83. 2010
    ..Our results suggest the formation of spatially and functionally distinct inflammasomes complexes in response to bacterial pathogens...
  6. doi Active caspase-1 is a regulator of unconventional protein secretion
    Martin Keller
    Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 132:818-31. 2008
    ..By this mechanism, stress-induced activation of caspase-1 directly links inflammation to cytoprotection, cell survival, and regenerative processes...
  7. doi The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    Daniel A Muruve
    Department of Medicine, University of Calgary, Alberta T2N 4N1, Canada
    Nature 452:103-7. 2008
    ..Thus, in addition to viral and bacterial components or danger signals in general, inflammasomes sense potentially dangerous cytoplasmic DNA, strengthening their central role in innate immunity...
  8. pmc Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
    Susan L Fink
    Molecular and Cellular Biology Program, Departments of Microbiology and Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:4312-7. 2008
    ....
  9. doi Superoxide dismutase 1 regulates caspase-1 and endotoxic shock
    Felix Meissner
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
    Nat Immunol 9:866-72. 2008
    ..Our findings identify a physiological post-translational mechanism in the control of caspase-1-mediated inflammatory processes...
  10. pmc Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
    Jonathan W Jones
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:9771-6. 2010
    ..Finally, AIM2-deficient mice displayed increased susceptibility to F. tularensis infection compared with wild-type mice. Their increased bacterial burden in vivo confirmed that AIM2 is essential for an effective innate immune response...
  11. pmc NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways
    Stephen B Willingham
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 183:2008-15. 2009
    ..These results provide critical in vivo validation that the physiologic role of NLRP3 and ASC is not limited to inflammasome formation...
  12. ncbi The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
    J Yuan
    Program of Neurosciences, Harvard Medical School, Boston, Massachusetts 02115
    Cell 75:641-52. 1993
    ..We propose that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteine proteases also function in programmed cell death in mammals...
  13. pmc NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
    Sinead M Miggin
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 104:3372-7. 2007
    ..This functional interaction reveals an important aspect of the coordination between TLRs and caspase-1 during the innate response to pathogens...
  14. doi Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages
    Tatsukuni Ohno
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Immunol 183:7890-7. 2009
    ..These observations suggest that caspase-1-, caspase-8-, and calpain-independent IL-33 production by macrophages and/or mast cells may contribute to the pathogenesis of Th2-type allergic inflammation...
  15. ncbi Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock
    P Li
    BASF Bioresearch Corporation, Worcester, Massachusetts 01605 4314
    Cell 80:401-11. 1995
    IL-1 beta-converting enzyme (ICE) cleaves pro-IL-1 beta to generate mature IL-1 beta. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/lch-1...
  16. pmc Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8
    Jonathan Maelfait
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    J Exp Med 205:1967-73. 2008
    ..These results implicate a novel role for caspase-8 in the production of biologically active IL-1beta in response to TLR3 and TLR4 stimulation...
  17. pmc The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1
    D Hersh
    Skirball Institute, Department of Microbiology and Kaplan Cancer Center, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 96:2396-401. 1999
    ..Taken together, the data demonstrate that SipB functions as an analog of the Shigella invasin IpaB...
  18. pmc Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis
    Patrick J Shaw
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38104, USA
    J Immunol 184:4610-4. 2010
    ..We found that CD4(+) T cells deficient in ASC exhibited impaired survival; accordingly, ASC(-/-) mice had fewer myelin oligodendrocyte glycoprotein-specific T cells in the draining lymph nodes and CNS...
  19. pmc The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation
    M Galle
    Department of Molecular Biology, Ghent University, Ghent, Belgium
    J Cell Mol Med 12:1767-76. 2008
    ..Altogether, these data demonstrate a dual role for the P. aeruginosa T3SS in the regulation of Caspase-1 mediated IL-1beta production and provide new insights into the mechanisms of immune evasion by this pathogen...
  20. pmc Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation
    Tessa Bergsbaken
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    J Immunol 187:2748-54. 2011
    ..These studies indicate two conserved secretion pathways are initiated by caspase-1, lysosome exocytosis, and a parallel pathway resulting in cytokine release, and both enhance the antimicrobial nature of pyroptosis...
  21. ncbi Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage
    X H Liu
    Department of Pediatrics, The University of Michigan, Ann Arbor, USA
    J Cereb Blood Flow Metab 19:1099-108. 1999
    Interleukin-1 (IL-1) converting enzyme (ICE) is a cysteine protease that cleaves inactive pro-IL-1beta to active IL-1beta...
  22. pmc Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death
    Wen Hua Zhang
    Department of Neurosurgery, Qilu Hospital, Shandong University, 250012, People s Republic of China
    Proc Natl Acad Sci U S A 100:16012-7. 2003
    ....
  23. doi Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells
    Andreas Weigert
    Institute of Biochemistry I Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit ZAFES, Goethe University Frankfurt, Frankfurt, Germany
    Blood 115:3531-40. 2010
    ..Our data link signaling events during apoptosis to the extracellular production of a lipid mediator that affects immune cell attraction and activation...
  24. pmc In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin
    Claudia Hoffmann
    Institute of Microbiology, D BIOL, ETH Zurich, Zurich, Switzerland
    PLoS ONE 5:e12477. 2010
    ..7 macrophages which is further enhanced independently by SopE and/or flagellin...
  25. pmc Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment
    Mahtab Moayeri
    Laboratory of Bacterial Diseases, Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 6:e1001222. 2010
    ..These data confirm an inverse relationship between murine macrophage sensitivity to lethal toxin and mouse susceptibility to spore infection, and establish roles for Nlrp1b(S), caspase-1, and IL-1β in countering anthrax infection...
  26. pmc A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages
    Ying Zheng
    Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Pathog 7:e1002026. 2011
    ..This pro-inflammatory form of apoptosis may represent an early innate immune response to highly virulent pathogens such as Y. pestis KIM that have evolved an enhanced ability to inhibit host signaling pathways...
  27. pmc Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice
    Vyacheslav Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, 4200 East 9th Avenue, Denver, Colorado 80262, USA
    J Clin Invest 110:1083-91. 2002
    ..These results suggest a novel neutrophil-independent mechanism of IL-18-mediated ischemic ARF...
  28. ncbi Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:18810-8. 2007
    ....
  29. doi Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes
    Kohsuke Tsuchiya
    Department of Microbiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Immunol 185:1186-95. 2010
    ..monocytogenes-infected macrophages. These results suggest that AIM2, in cooperation with NLRP3 and NLRC4, plays an important role in the activation of caspase-1 during L. monocytogenes infection...
  30. ncbi ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions
    Anasuya Sarkar
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus 43210, USA
    J Immunol 176:4979-86. 2006
    ..These data suggest that ASC may direct caspase-1 away from RIP2-mediated NF-kappaB activation, toward caspase-1-mediated processing of proIL-1beta by interfering with the RIP2 caspase-1 interaction...
  31. ncbi Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing
    Raynal C Squires
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 282:34260-7. 2007
    ..Taken together, caspase-1-mediated necrosis appears to be tightly controlled and differentially regulated by proteasomes depending on the source of caspase-1 induction...
  32. pmc Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice
    A Mencacci
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy
    Infect Immun 68:5126-31. 2000
    b>Caspase 1, formerly designated interleukin 1beta (IL-1beta)-converting enzyme, processes pro-IL-1beta and pro-IL-18 to yield active cytokines that play a pivotal role in inflammation and cell activation...
  33. ncbi Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction
    Stefan Frantz
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, MA 02115, Boston, USA
    J Mol Cell Cardiol 35:685-94. 2003
    ....
  34. pmc Type I interferon signaling is required for activation of the inflammasome during Francisella infection
    Thomas Henry
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    J Exp Med 204:987-94. 2007
    ..This connection underscores the importance of the cytosolic recognition of pathogens and highlights how multiple innate immunity pathways interact before commitment to critical host responses...
  35. pmc The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
    T Fernandes-Alnemri
    Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Death Differ 14:1590-604. 2007
    ..Our results establish that macrophage pyroptosis is mediated by a unique pyroptosome, distinct from the inflammasome...
  36. pmc Caspase-1 mediates resistance in murine melioidosis
    Katrin Breitbach
    Friedrich Loeffler Institute of Medical Microbiology, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Infect Immun 77:1589-95. 2009
    ..pseudomallei in macrophages. Moreover, caspase-1-dependent IFN-gamma production is likely to contribute to resistance in murine melioidosis...
  37. pmc Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death
    K A Roth
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 97:466-71. 2000
    ....
  38. pmc Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, South San Francisco, CA 94080, USA
    J Exp Med 202:1043-9. 2005
    ....
  39. pmc Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
    Maria Lara-Tejero
    Section of Microbial Pathogenesis, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    J Exp Med 203:1407-12. 2006
    ..We show here that absence of caspase-1 or components of the inflammasome does not result in resistance to oral infection by S. typhimurium, but rather, leads to increased susceptibility to infection...
  40. ncbi Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
    Thirumala Devi Kanneganti
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:36560-8. 2006
    ..These results identify a mechanism mediated by cryopyrin and ASC that links dsRNA and viral infection to caspase-1 activation resulting in IL-1beta and IL-18 production...
  41. pmc Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes
    Mohamed Lamkanfi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 7:2350-63. 2008
    ....
  42. pmc Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B
    Tatjana Eigenbrod
    Department of Infectious Diseases, Medical Microbiology and Hygiene, University of Heidelberg, 69120 Heidelberg, Germany
    J Immunol 189:328-36. 2012
    ..Thus, our data indicate the presence of a yet unidentified intracellular nucleic acid receptor involved in bacterial RNA-induced inflammasome activation and release of IL-1β...
  43. pmc Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia
    Chun Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th St, Richmond, VA 23298, USA
    Hypertension 60:154-62. 2012
    ..complex consisting of Nod-like receptor protein 3 (NALP3), apoptosis-associated speck-like protein (ASC), and caspase 1 or 5, which functions to switch on the inflammatory process...
  44. ncbi Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death
    Xin Wang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, LMRC 123, Boston, MA 02115, USA
    Biochim Biophys Acta 1762:742-54. 2006
    ..Cop, as an inhibitor of an important apical caspase cell death axis, may provide a tool for modulating pathological cell death...
  45. pmc The caspase 1 inflammasome is not required for control of murine Lyme borreliosis
    Nengyin Liu
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 77:3320-7. 2009
    ..These cytokines are released in active forms after cleavage by the inflammasome-associated enzyme caspase 1. To investigate the contribution of the inflammasome to host defense against B...
  46. pmc Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
    Shankar S Iyer
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:20388-93. 2009
    ..These findings suggest that the inhibition of Nlrp3 inflammasome activity can diminish the acute inflammation and damage associated with tissue injury...
  47. pmc Comparison of two mice strains, A/J and C57BL/6, in caspase-1 activity and IL-1beta secretion of macrophage to Mycobacterium leprae infection
    Tae Jin Kang
    Institute of Chronic Disease, College of Pharmacy, Sahmyook University, 26 21 Kongnung 2 dong, Nowon Gu, Seoul 139 742, Republic of Korea
    Mediators Inflamm 2010:708713. 2010
    ..However, macrophages from A/J mice exhibited reduced caspase-1 activation and IL-1beta secretion compared to C57BL/6 macrophages. These results suggest that NLR family proteins may have a role in the innate immune response to M. leprae...
  48. ncbi Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
    M B Glaccum
    Immunex Corporation, Seattle, WA 98101, USA
    J Immunol 159:3364-71. 1997
    ..Interestingly, ICE-/-/type I IL-1R-/- double mutant mice are resistant to high dose LPS...
  49. pmc Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways
    Tae Jin Kang
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Eur J Immunol 38:1574-84. 2008
    ..Thus different components of the same bacterium each induce IL-1beta by distinct signaling pathways. Whereas the spore-induced IL-1beta limits BA infection, LT-induced IL-1beta enables BA to escape host defenses...
  50. pmc Interleukin-33 is biologically active independently of caspase-1 cleavage
    Dominique Talabot-Ayer
    Division of Rheumatology, University Hospital, and Department of Pathology and Immunology, University of Geneva School of Medicine, 1211 Geneva 4, Switzerland
    J Biol Chem 284:19420-6. 2009
    ..In addition, our results clearly show that caspase-1 cleavage is not required for pro-IL-33 secretion and bioactivity, highlighting major differences between IL-1beta and IL-33...
  51. ncbi Characterization of mice deficient in interleukin-1 beta converting enzyme
    P Li
    BASF Bioresearch Corporation, Worcester, Massachusetts 01605 4314, USA
    J Cell Biochem 64:27-32. 1997
    Interleukin-1 beta converting enzyme (ICE) processes the inactive prolL-1 beta to the proinflammatory mature IL-1 beta. ICE belongs to a family of cysteine proteases that have been implicated in apoptosis...
  52. ncbi Roles of caspase-1 in Listeria infection in mice
    Noriko M Tsuji
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06510, USA
    Int Immunol 16:335-43. 2004
    Caspase-1 [IL-1beta-converting enzyme (ICE)] processes substrate precursor molecules to yield the biologically active form of IL-1beta and IL-18, both of which are considered to play important roles in the host defense by activation of ..
  53. pmc Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity
    Tao Ren
    Genetics Department, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Pathog 2:e18. 2006
    ..It thus appears that macrophages sense cytosolic flagellin via a TLR5-independent pathway that leads to rapid caspase-1-dependent cell death and provides defense against intracellular bacterial pathogens...
  54. ncbi MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3
    Qilin Pan
    Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
    J Leukoc Biol 82:177-83. 2007
    ..Together, our data provide a new understanding of this important pathway of IL-1beta production and allow for further studies of the role of these proteins within the broader context of inflammatory disease...
  55. ncbi Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Eur J Immunol 37:3030-9. 2007
    ..These results provide new insight into the interaction of P. aeruginosa with host macrophages and suggest that distinct regions of flagellin are sensed by Ipaf and TLR5...
  56. pmc Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome
    Fayyaz S Sutterwala
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 204:3235-45. 2007
    ..This study shows a key role for IPAF and capase-1 in innate immune responses to the pathogen P. aeruginosa, and also demonstrates that virulent ExoU-expressing strains of P. aeruginosa can circumvent this innate immune response...
  57. pmc Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
    Karla L Lightfield
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Nat Immunol 9:1171-8. 2008
    ..These mice failed to activate the inflammasome in response to the 35 amino acids of flagellin or in response to Legionella pneumophila infection. Our data clarify the molecular basis for the cytosolic response to flagellin...
  58. ncbi Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases
    A Sarin
    Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Immunity 6:209-15. 1997
    Activation of ICE/Ced-3 family proteases (caspases) has been proposed to mediate both the granule exocytosis and Fas-Fas ligand pathways of rapid target cell death by cytotoxic T lymphocytes...
  59. ncbi ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules
    Masatatsu Yamamoto
    Department of Molecular Oncology Division of Molecular and Cellular Biology Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Genes Cells 9:1055-67. 2004
    ..These results demonstrate critical roles for ASC in the release of IL-1beta/IL-18 via activation of caspase-1 and provide new insights into the inflammatory responses for host defence and diseases...
  60. ncbi Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf
    Amal Amer
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:35217-23. 2006
    ..These results reveal that Ipaf restricts Legionella replication through the regulation of phagosome maturation, providing a novel function for NLR proteins in host defense against an intracellular bacterium...
  61. ncbi Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages
    Yan Qu
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
    J Immunol 179:1913-25. 2007
    ..Our findings suggest an alternative model of IL-1 beta release that may involve the P2X7R-induced formation of multivesicular bodies that contain exosomes with entrapped IL-1 beta, caspase-1, and other inflammasome components...
  62. pmc Pseudomonas aeruginosa activates caspase 1 through Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 105:2562-7. 2008
    The innate immune system encodes cytosolic Nod-like receptors (NLRs), several of which activate caspase 1 processing and IL-1beta and IL-18 secretion...
  63. pmc A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
    Li Chung Hsu
    Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:7803-8. 2008
    ..Thus, NOD2 plays a key role in the B. anthracis-induced inflammatory response by being a critical mediator of IL-1beta secretion...
  64. pmc Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis
    Tatiana N Silveira
    Department of Cell Biology, University of Sao Paulo, Medical School Ribeirão Preto, SP 14049 900 Brazil
    Infect Immun 78:1403-13. 2010
    ..pneumophila specific nor the result of membrane damage induced by Dot/Icm activity; instead, it is a highly coordinated host cell response dependent on host Nlrc4 and caspase-1 and on bacterial flagellin and type IV secretion system...
  65. pmc In vivo discrimination of type 3 secretion system-positive and -negative Pseudomonas aeruginosa via a caspase-1-dependent pathway
    Tamding Wangdi
    Department of Internal Medicine Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 78:4744-53. 2010
    ..Thus, the activation of caspase-1 by bacteria expressing type 3 secretion systems allows for rapid recognition of bacteria expressing conserved functions associated with virulence...
  66. ncbi Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant
    O A Andreassen
    Neurochemistry Laboratory, Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Neurochem 75:847-52. 2000
    ..These results provide further evidence of a functional role for caspase-1 in both malonate- and 3-NP-mediated neurotoxin models of HD...
  67. ncbi Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and p
    Kristen M Clements
    Imperial College London, London, UK
    Arthritis Rheum 48:3452-63. 2003
    ..the medial collateral ligament and partial medial meniscectomy in mice in which genes encoding either interleukin-1beta (IL-1beta), IL-1beta-converting enzyme (ICE), stromelysin 1, or inducible nitric oxide synthase (iNOS) were deleted.
  68. ncbi Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice
    Wei Wang
    Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Renal Physiol 288:F997-1004. 2005
    ..Neutralization of IL-1beta and IL-18 is not functionally protective. The role of the intracellular proinflammatory cytokine IL-1alpha in endotoxemic ARF merits further study...
  69. pmc Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    Stephanie C Eisenbarth
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 453:1122-6. 2008
    ..This is likely to affect how we design effective, but safe, adjuvants in the future...
  70. ncbi Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme
    K Kuida
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 267:2000-3. 1995
    The interleukin-1 beta (IL-1 beta) converting enzyme (ICE) processes the inactive IL-1 beta precursor to the proinflammatory cytokine...
  71. ncbi Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
    M Miura
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129
    Cell 75:653-60. 1993
    The mammalian interleukin-1 beta-converting enzyme (ICE) has sequence similarity to the C. elegans cell death gene ced-3. We show here that overexpression of the murine ICE (mICE) gene or of the C...
  72. pmc A bacterial invasin induces macrophage apoptosis by binding directly to ICE
    Y Chen
    Skirball Institute, Department of Microbiology and Kaplan Cancer Center, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    EMBO J 15:3853-60. 1996
    ..which were identified as the precursor and the mature polypeptides of interleukin-1beta converting enzyme (ICE) or a highly homologous protease. We found that IpaB binds directly to ICE and this enzyme is activated during S...
  73. ncbi Response to local inflammation of IL-1 beta-converting enzyme- deficient mice
    G Fantuzzi
    Department of Medicine, Tufts University School of Medicine and New England Medical Center, Boston, MA 02111, USA
    J Immunol 158:1818-24. 1997
    IL-1 beta-converting enzyme (ICE) cleaves pro-IL-1 beta to the mature, released form. Although other proteases can process pro-IL-1 beta, ICE-deficient (ICE -/-) mice do not release mature IL-1 beta in response to endotoxin...
  74. ncbi The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice
    M Los
    Department of Internal Medicine I, Medical Clinics, University of Tubingen, Germany
    Immunity 10:629-39. 1999
  75. pmc Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model
    D M Monack
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, California 94305, USA
    J Exp Med 192:249-58. 2000
    ..These results show that Casp-1, which is both proapoptotic and proinflammatory, is essential for S. typhimurium to efficiently colonize the cecum and PP and subsequently cause systemic typhoid-like disease in mice...
  76. ncbi Altered cytokine production in mice lacking P2X(7) receptors
    M Solle
    Department of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases, Pfizer Inc, Groton, Connecticut 06340, USA
    J Biol Chem 276:125-32. 2001
    ..Together these results demonstrate that P2X(7)R activation can provide a signal that leads to maturation and release of IL-1 beta and initiation of a cytokine cascade...
  77. pmc Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure
    V Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Clin Invest 107:1145-52. 2001
    ..Finally, we confirmed histologically that caspase-1(-/-) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration...
  78. pmc Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia
    Vishwas D Joshi
    Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 70:6896-903. 2002
    ..We studied the role of caspase 1 (Cas-1) in the murine innate immune response to infection with gram-negative bacteria and to nonlethal and ..
  79. ncbi Salmonella rapidly kill dendritic cells via a caspase-1-dependent mechanism
    Adrianus W M van der Velden
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 171:6742-9. 2003
    ..We hypothesize that Salmonella have evolved the ability to selectively kill professional APCs to combat, exploit, or evade immune defense mechanisms...
  80. ncbi Caspase-1 is not required for type 1 diabetes in the NOD mouse
    William H Schott
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Diabetes 53:99-104. 2004
    ..To examine the effects produced by caspase-1 deficiency on diabetes development in NOD/Lt mice, a disrupted Casp1 gene was introduced by a speed congenic technique...
  81. ncbi Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release
    J Michelle Kahlenberg
    Dept of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Am J Physiol Cell Physiol 286:C1100-8. 2004
    ....
  82. ncbi Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice
    Archana Thakur
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 4820, USA
    Curr Eye Res 29:225-33. 2004
    ..To elucidate these mechanisms, caspase-1 knockout (ICE(-/-)) mice, that do not release mature IL-1 beta after endotoxin challenge, were tested.
  83. ncbi Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor
    Philip A Verhoef
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Immunol 175:7623-34. 2005
    ..These results suggest that under physiological conditions P2X7R are maintained in a conformationally restrained state that limits channel gating and coupling of the receptor to signaling pathways that regulate caspase-1...
  84. ncbi Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    Thirumala Devi Kanneganti
    University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Nature 440:233-6. 2006
    ..These results reveal a critical role for cryopyrin in host defence through bacterial RNA-mediated activation of caspase-1, and provide insights regarding the pathogenesis of autoinflammatory syndromes...
  85. ncbi The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection
    Dario S Zamboni
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nat Immunol 7:318-25. 2006
    ..These results establish Birc1e as a nucleotide-binding oligomerization-leucine-rich repeat protein involved in the detection and control of intracellular L. pneumophila...
  86. ncbi Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
    Fayyaz S Sutterwala
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:317-27. 2006
    ..These data suggest that NALP3 plays a specific role in the caspase-1 activation pathway...
  87. pmc Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection
    Barbel Raupach
    Department of Cellular Microbiology, Max Planck Institut für Infektionsbiologie, Schumannstrasse 21 22, 10117 Berlin, Germany
    Infect Immun 74:4922-6. 2006
    ..Thus, we show that Casp-1 is essential for host innate immune defense against S. enterica serovar Typhimurium and that Casp-1 substrates are required at distinct times and anatomical sites...
  88. pmc Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18
    Anasuya Sarkar
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Am J Respir Crit Care Med 174:1003-10. 2006
    ..In this context, caspase-1 knockout mice have been shown to be protected from endotoxin-induced mortality, whereas IL-1beta knockout mice are not protected...
  89. ncbi The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression
    Christian Bauer
    Division of Clinical Pharmacology, Medizinische Klinik Innenstadt of the University of Munich, Munich, Germany
    Dig Dis Sci 52:1642-52. 2007
    Previously we demonstrated an ameliorating effect of the interleukin-1beta converting enzyme (ICE) inhibitor pralnacasan on dextran sulfate sodium (DSS)-induced colitis...
  90. ncbi Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
    Chun Jen Chen
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Room S2 109, Worcester, Massachusetts 01655, USA
    Nat Med 13:851-6. 2007
    ....
  91. ncbi The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
    Wei Shao
    Department of Biochemistry, Division of Critical Care, Centre for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada
    J Biol Chem 282:36321-9. 2007
    ..The systematic characterization of caspase-1 substrates identifies the glycolysis pathway as a caspase-1 target and provides new insights into its function during pyroptosis and septic shock...
  92. pmc Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection
    Sarah E Warren
    Department of Immunology, University of Washington, Seattle WA 98195, USA
    J Immunol 180:7558-64. 2008
    ..Cytosolic L. monocytogenes activates caspase 1, resulting in post-translational processing of the cytokines IL-1beta and IL-18 as well as caspase 1-dependent ..
  93. pmc Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3
    Hanfen Li
    Department Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Immunol 181:17-21. 2008
    ....
  94. pmc The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
    Annett Halle
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 9:857-65. 2008
    ..Our findings suggest that activation of the NALP3 inflammasome is important for inflammation and tissue damage in Alzheimer's disease...
  95. pmc AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    Veit Hornung
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 458:514-8. 2009
    ..Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1...
  96. pmc Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila
    Christopher L Case
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Infect Immun 77:1981-91. 2009
    ..pneumophila replication in mice. Thus, L. pneumophila-mediated caspase-1 activation involves the coordinate activities of inflammasomes differentially regulated by Ipaf and Asc...
  97. doi Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
    Olaf Gross
    III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Nature 459:433-6. 2009
    ..member that transduces the fungal recognition signal to the inflammasome adaptor Asc (Pycard) for Caspase-1 (Casp1) activation and pro-IL-1beta processing...
  98. pmc The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
    Irving C Allen
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 30:556-65. 2009
    ..Together, these data place the NLRP3 inflammasome as an essential component in host defense against influenza infection through the sensing of viral RNA...
  99. pmc The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
    Paul G Thomas
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 30:566-75. 2009
    ..Here, we demonstrated that Nlrp3(-/-) and Casp1(-/-) mice were more susceptible than wild-type mice after infection with a pathogenic influenza A virus...
  100. doi Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases
    Alexander U Lüthi
    Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
    Immunity 31:84-98. 2009
    ..Thus, caspase-mediated proteolysis acts as a switch to dampen the proinflammatory properties of IL-33...
  101. doi The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation
    Andreas J Müller
    Institute of Microbiology, D BIOL, ETH Zurich, Zurich CH 8093, Switzerland
    Cell Host Microbe 6:125-36. 2009
    ..These findings implicate SopE-driven Rho GTPase-mediated caspase-1 activation in stromal cells as a mechanism eliciting mucosal inflammation during S. Typhimurium infection...

Research Grants6

  1. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  2. CARDIAC LESIONS IN HIV1 TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2001
    ..the development of cardiac lesions; 5) To determine whether the ablation of specific host genes (IL-6,TNF,R, iNOS, ICE) prevents the appearance of cardiac lesions; 6) To determine the role of monocytes/macrophages derived cytokines in ..
  3. CHEMOKINES IN LUNG DISEASE OF HIV1 TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2003
    ..4- To determine whether blocking or deleting specific chemokines or their receptors and overexpressing some chemokine receptors alter the development of lymphocytic interstitial pneumonitis. ..
  4. STUDIES OF LUNG DISEASES OF HIV TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2009
    ..This research is especially relevant to public health, especially children with AIDS, developing lung diseases at high frequency. ..
  5. Modulation of Host Cell Functions by Coxiella burnetii
    Craig R Roy; Fiscal Year: 2010
    ..These studies will elucidate pathogenic determinants that allow host cell infection by Coxiella and reveal intracellular infection strategies employed by this important pathogen. ..
  6. PROTEIN PROFILING OF ORAL MUCOSA OF HIV TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2010
    ..This research is especially relevant to public health in view of the high frequency of oral complications (especially candidiasis) in HIV-1 infected individuals. ..