Car2

Summary

Gene Symbol: Car2
Description: carbonic anhydrase 2
Alias: AI131712, CAII, Ca2, Car-2, Ltw-5, Lvtw-5, CA II, CA-II, carbonate dehydratase II, carbonic anhydrase II
Species: mouse

Top Publications

  1. ncbi Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation
    M Burmeister
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720, USA
    Nat Genet 12:376-84. 1996
  2. ncbi The AXB and BXA set of recombinant inbred mouse strains
    J D Marshall
    Jackson Laboratory, Bar Harbor, Maine 04609 1500
    Mamm Genome 3:669-80. 1992
  3. ncbi Mapping of the mouse 86-kDa heat-shock protein expressed gene (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4, 9, and 11
    S K Moore
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 10:1019-29. 1991
  4. ncbi A locus for circadian period of locomotor activity on mouse proximal chromosome 3
    Kari L Kernek
    Program in Medical Neurobiology, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Chronobiol Int 21:343-52. 2004
  5. pmc Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium
    Janet E Simpson
    Dalton Cardiovascular Research Center, Univ of Missouri Columbia, 65211, USA
    Am J Physiol Gastrointest Liver Physiol 298:G683-91. 2010
  6. pmc N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome
    S E Lewis
    Research Triangle Institute, NC 27709
    Proc Natl Acad Sci U S A 85:1962-6. 1988
  7. ncbi Expression and role of laminin-1 in mouse pancreatic organogenesis
    C A Crisera
    Children s Mercy Hospital, Kansas City, Missouri 64108 4698, USA
    Diabetes 49:936-44. 2000
  8. ncbi Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors
    M L Mucenski
    NCI Frederick Cancer Research Facility, BRI Basic Research Program, Maryland 21701
    Oncogene Res 2:219-33. 1988
  9. pmc Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2
    Mari Leppilampi
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, FI 33520 Tampere, Finland
    Proc Natl Acad Sci U S A 102:15247-52. 2005
  10. pmc Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice
    Peiwen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    J Physiol 571:319-27. 2006

Research Grants

Scientific Experts

  • STEVEN MUNGER
  • David S Margolis
  • A R Mayeda
  • Bjarne Knudsen
  • Pei wen Pan
  • O V Savinova
  • M Vuillemin
  • Kari L Kernek
  • Markus Sjöblom
  • Manoocher Soleimani
  • Gerolf Gros
  • Ling Wu
  • Karam Aboudehen
  • Malin H Stridh
  • W Cammer
  • Brigitte Riederer
  • Ursula Seidler
  • Janet E Simpson
  • Xiaogu Wang
  • Makiko Nagata
  • Sonia Palminiello
  • Zishu Pan
  • Xuming Sun
  • Ji Hu
  • Mireya Gonzalez-Begne
  • Zenta Yasukawa
  • Matthew D Beekley
  • Akari Inada
  • C Nguyen
  • Umashankar Singh
  • Francois Jouret
  • Mari Leppilampi
  • James A Trofatter
  • John R Hofstetter
  • Fiona E Karet
  • JINING LU
  • Hongwei Dou
  • Y H Lien
  • B A Taylor
  • Eitan Gross
  • Jinwoong Bok
  • Borum Sagong
  • Un Kyung Kim
  • Jae Young Choi
  • Marco D Alt
  • Hella Heidtmann
  • Gunther Wennemuth
  • Sarah Wittmann
  • Zubaida Saifudeen
  • Sylvia Hilliard
  • Robert McKenna
  • Holger M Becker
  • Samir S El-Dahr
  • Q Zhou
  • Joachim W Deitmer
  • Mayank Aggarwal
  • Baohong Zhao
  • Masanori Nakamura
  • Yoichi Miyamoto
  • Riko Nishimura
  • Tomio Inoue
  • Kazuyoshi Baba
  • Tetsuo Suzawa
  • C A Crisera
  • Hirotada Ohtsuka
  • Lane L Clarke
  • Claudiu T Supuran
  • Ryutaro Kamijo
  • Nancy M Walker
  • D S Goldfarb
  • Tomohiko Miyauchi
  • L W Lai
  • Bi guang Tuo
  • Anurag Kumar Singh
  • Hiroshi Koyama
  • Kazuhisa Sekimizu
  • Nagisa Arimitsu
  • Takahiro Ito
  • Jian Wang
  • Wen Zheng
  • Anja Krabbenhöft
  • P Mezquita
  • Kurt Benirschke
  • Shaheen Sikandar
  • Paul Vrana
  • Elizabeth Kida
  • Diana Dizon
  • Marius Walus
  • Christopher Wiley
  • Adam A Golabek

Detail Information

Publications76

  1. ncbi Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation
    M Burmeister
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720, USA
    Nat Genet 12:376-84. 1996
    ..off..
  2. ncbi The AXB and BXA set of recombinant inbred mouse strains
    J D Marshall
    Jackson Laboratory, Bar Harbor, Maine 04609 1500
    Mamm Genome 3:669-80. 1992
    ..Thus, the AXB and BXA set of RI strains will be useful in the genetic analysis of several complex diseases...
  3. ncbi Mapping of the mouse 86-kDa heat-shock protein expressed gene (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4, 9, and 11
    S K Moore
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 10:1019-29. 1991
    ..An HSP86-related locus specific to NFS/N and C58/J mice, designated Hsp86-ps3, was mapped on Chromosome 9. Also, an HSP86-related locus that was unique to NFS/N mice, designated Hsp86-ps4, was mapped to Chromosome 4...
  4. ncbi A locus for circadian period of locomotor activity on mouse proximal chromosome 3
    Kari L Kernek
    Program in Medical Neurobiology, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Chronobiol Int 21:343-52. 2004
    ..activity is a characteristic of a congenic strain of mice carrying a nonsense mutation in exon 5 of the carbonic anhydrase II gene, car2...
  5. pmc Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium
    Janet E Simpson
    Dalton Cardiovascular Research Center, Univ of Missouri Columbia, 65211, USA
    Am J Physiol Gastrointest Liver Physiol 298:G683-91. 2010
    ..Pat-1 interacts with carbonic anhydrase II (CAII), and studies using CAII(-) intestine or the pharmacological inhibitor methazolamide on WT intestine ..
  6. pmc N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome
    S E Lewis
    Research Triangle Institute, NC 27709
    Proc Natl Acad Sci U S A 85:1962-6. 1988
    ..progeny of male mice treated with N-ethyl-N-nitrosourea revealed a mouse that lacked the paternal carbonic anhydrase II (CA II)...
  7. ncbi Expression and role of laminin-1 in mouse pancreatic organogenesis
    C A Crisera
    Children s Mercy Hospital, Kansas City, Missouri 64108 4698, USA
    Diabetes 49:936-44. 2000
    ..Immunohistochemistry, however, showed that pancreatic duct cell-specific differentiation (carbonic anhydrase II) without ductal morphogenesis was still present, despite the blockage of duct morphogenesis by the anti-..
  8. ncbi Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors
    M L Mucenski
    NCI Frederick Cancer Research Facility, BRI Basic Research Program, Maryland 21701
    Oncogene Res 2:219-33. 1988
    ..These results suggest that Evi-1 represents a new locus involved in myeloid disease...
  9. pmc Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2
    Mari Leppilampi
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, FI 33520 Tampere, Finland
    Proc Natl Acad Sci U S A 102:15247-52. 2005
    ..b>CA II- and IX-deficient mice and different combinations of their heterozygous and WT counterparts were studied...
  10. pmc Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice
    Peiwen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland
    J Physiol 571:319-27. 2006
    ..isozymes (CA) I, II, III, IV, IX, XII, XIII and XIV in the brain, kidney, stomach and colon of the wild-type, CA II-deficient (Car2-/-), and CA IX deficient (Car9-/-) mice...
  11. ncbi Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1
    W S Moseley
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 5:899-905. 1989
    ..These studies provide a model for examination of specific evolutionary events...
  12. doi A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development
    Ling Wu
    Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea
    Dev Dyn 242:269-80. 2013
    ..To understand the specific roles of CA isozymes in the inner ear, a systematic survey was conducted to reveal temporal and spatial expression patterns of all 16 CA isozymes during inner ear development...
  13. pmc Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II
    Malin H Stridh
    Division of General Zoology, Department of Biology, University of Kaiserslautern, PO Box 3049, D 67653 Kaiserslautern, Germany
    J Physiol 590:2333-51. 2012
    ..In the present study, we report that carbonic anhydrase 2 (CAII) enhances both influx and efflux of lactate in mouse cerebellar astrocytes...
  14. pmc Mechanisms of p53 activation and physiological relevance in the developing kidney
    Karam Aboudehen
    Department of Pediatrics, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 302:F928-40. 2012
    ..We speculate that the stress/hypoxia of the embryonic microenvironment may provide the stimulus for p53 activation in the developing kidney...
  15. pmc Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function
    Q Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana, IL 61802, USA
    Proc Natl Acad Sci U S A 98:14132-7. 2001
    ..Immunohistochemical staining for NHE3, carbonic anhydrase II (CAII), and aquaporin-I (AQP1) was decreased in ER alpha knockout (alpha ERKO) efferent ductules...
  16. ncbi Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1
    Umashankar Singh
    Department of Development and Genetics, Evolutionary Biology Center, Uppsala University, Sweden
    Dev Dyn 234:1034-45. 2005
    ..In the present study, we focused on two genes, Car2 and Ncam1, which both exhibited increased expression in interspecies and cloned hyperplastic placentas...
  17. ncbi Respiratory acidosis in carbonic anhydrase II-deficient mice
    Y H Lien
    Department of Medicine, University of Arizona Health Sciences Center, Tucson 85724, USA
    Am J Physiol 274:L301-4. 1998
    ..the role of carbonic anhydrase (CA) II on pulmonary CO2 exchange, we analyzed arterial blood gases from CA II-deficient and normal control mice. CA II-deficient mice had a low arterial blood pH (7.18 +/- 0...
  18. ncbi Different susceptibility of mice to immune-mediated cholangitis induced by immunization with carbonic anhydrase II
    Y Ueno
    Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Lab Invest 78:629-37. 1998
    b>Carbonic anhydrase II (CA-II), an enzyme that catalyzes hydration of carbon dioxide to bicarbonate and hydrogen ions, is located exclusively in cholangiocytes in the liver...
  19. ncbi Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis
    Francois Jouret
    Division of Nephrology, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels, Belgium B 1200
    J Am Soc Nephrol 16:3235-46. 2005
    ..They provide new insights into the complex regulation of V-ATPase subunits, the maturation of IC along the nephron, and the pathophysiology of hereditary dRTA...
  20. ncbi Novel transcripts of carbonic anhydrase II in mouse and human testis
    P Mezquita
    Laboratori de Genètica Molecular, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Spain
    Mol Hum Reprod 5:199-205. 1999
    ..b>Carbonic anhydrase II, catalysing the synthesis of bicarbonate within spermatozoa, must play a significant role in these ..
  21. ncbi Acid-base effects on electrolyte transport in CA II-deficient mouse colon
    D S Goldfarb
    Nephrology Section, Veterans Affairs Medical Center and New York University School of Medicine, New York, New York 10010, USA
    Am J Physiol Gastrointest Liver Physiol 278:G409-15. 2000
    ..carbonic anhydrase (CA) in colonic electrolyte transport, we studied Car-2(0) mice, mutants deficient in cytosolic CA II. Ion fluxes were measured under short-circuit conditions in an Ussing chamber...
  22. ncbi Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and carbonic anhydrase II in epithelial cells of the murine endolymphatic sac
    Hongwei Dou
    Center for Hearing and Deafness Research, Department of Pediatric Otolaryngology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Histochem Cytochem 52:1377-84. 2004
    ..Pendrin- and vH+-ATPase-positive cells also expressed cytoplasmic CA II. Co-expression of pendrin, vH+-ATPase, and CA II in the same subgroup of ES cells suggests that this specific type ..
  23. pmc Intraocular pressure in genetically distinct mice: an update and strain survey
    O V Savinova
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    BMC Genet 2:12. 2001
    ....
  24. pmc Using evolutionary rates to investigate protein functional divergence and conservation. A case study of the carbonic anhydrases
    Bjarne Knudsen
    Bioinformatics Research Center, University of Aarhus, 8000 Aarhus C, Denmark
    Genetics 164:1261-9. 2003
    ..As illustrated by the CAs, these LRTs, in combination with other biological evidence, offer a powerful and cost-effective approach for testing hypotheses, making predictions, and designing experiments in protein functional studies...
  25. ncbi Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung
    JINING LU
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Dev Biol 273:418-35. 2004
    ..Our data suggest that these genes may regulate focal developmental events specific of each of these regions during respiratory tract formation...
  26. ncbi A single copy of carbonic anhydrase 2 restores wild-type circadian period to carbonic anhydrase II-deficient mice
    Kari L Kernek
    Program in Medical Neurobiology, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA
    Behav Genet 36:301-8. 2006
    b>Carbonic anhydrase II (CA-II)-deficient mice have long circadian periods compared to their siblings with normal CA-II levels...
  27. doi Carbonic anhydrases in the mouse harderian gland
    Pei wen Pan
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520 Tampere, Finland
    J Mol Histol 41:411-7. 2010
    ..Car5b and Car13 showed the highest signals. Car4, Car6, and Car12 showed moderate expression levels, whereas Car2, Car3, Car7, and Car15 mRNAs were barely within the detection limits...
  28. pmc An olfactory subsystem that detects carbon disulfide and mediates food-related social learning
    Steven D Munger
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Curr Biol 20:1438-44. 2010
    ..guanylyl cyclase GC-D, the cyclic nucleotide-gated channel subunit CNGA3, and the carbonic anhydrase isoform CAII (GC-D(+) OSNs) is required for the acquisition of socially transmitted food preferences (STFPs) in mice...
  29. doi Carbonic anhydrase II regulates differentiation of ameloblasts via intracellular pH-dependent JNK signaling pathway
    Xiaogu Wang
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    J Cell Physiol 225:709-19. 2010
    ..We found that the expression level of carbonic anhydrase II (CAII) is strongly up-regulated in parallel with differentiation of enamel epithelium tissues, while the ..
  30. pmc Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression
    Markus Sjöblom
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany
    Proc Natl Acad Sci U S A 106:13094-9. 2009
    ..The results suggest that CA II is important for duodenocyte acidification by low luminal pH and for eliciting the acid-mediated HCO(3)(-) ..
  31. doi Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation
    Makiko Nagata
    Department of Developmental Biochemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Genes Cells 14:371-80. 2009
    ..These results suggest that S-II is involved in transcription of the Bcl-x and beta(major)-globin gene during erythroblast differentiation, by relieving transcription arrest or affecting histone modification on chromatin template...
  32. ncbi Timing and expression pattern of carbonic anhydrase II in pancreas
    Akari Inada
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Dev Dyn 235:1571-7. 2006
    ..search for genetic markers for assessing the role of duct cells in pancreas growth, we examined whether carbonic anhydrase II (CAII) has ductal cell specificity...
  33. doi Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice
    Zishu Pan
    Department of Medicine, University of California, Irvine, Irvine, California 92697, USA
    Dev Dyn 237:316-27. 2008
    ..Our study demonstrates Alkbh1 performs important functions in placental trophoblast lineage differentiation and participates in mechanisms of transcriptional regulation...
  34. ncbi Increased levels of carbonic anhydrase II in the developing Down syndrome brain
    Sonia Palminiello
    San Raffaele Pisana, Rome and San Raffaele Cassino, Italy
    Brain Res 1190:193-205. 2008
    By using a proteomic approach, we found increased levels of carbonic anhydrase II (CA II) in the brain of Ts65Dn mice, a mouse model for Down syndrome (DS)...
  35. ncbi Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice
    Mireya Gonzalez-Begne
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 282:35125-32. 2007
    ..Indeed, the parotid glands of Nhe1(-/-) mice expressed higher levels of carbonic anhydrase 2 (Car2) polypeptide...
  36. ncbi Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse
    Ji Hu
    National Institute of Biological Sciences, Beijing, 102206, China
    Science 317:953-7. 2007
    ..038%). We demonstrated the expression of carbonic anhydrase type II (CAII), an enzyme that catabolizes CO2, in a subset of mouse olfactory neurons that express guanylyl cyclase D (GC-D+ ..
  37. pmc A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system
    Pei wen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520, Tampere, Finland
    BMC Mol Biol 8:22. 2007
    ..In the present study, we systematically examined the mRNA expression levels of all known CA isozymes by quantitative real-time PCR in eight tissues of the digestive system of male and female mice...
  38. ncbi Identification of an inflammation-inducible serum protein recognized by anti-disialic acid antibodies as carbonic anhydrase II
    Zenta Yasukawa
    Laboratory of Animal Cell Function, Bioscience and Biotechnology Center, Nagoya University, Nagoya 464 8601, Japan
    J Biochem 141:429-41. 2007
    ..The 32-kDa protein was identified as carbonic anhydrase II (CA-II), based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analyses of ..
  39. ncbi Sjögren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus
    C Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Scand J Immunol 64:295-307. 2006
    ..These data suggest SjS-like disease in the NOD mouse shows gender-specific regulation determined by autosomal genes...
  40. pmc Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding
    Eitan Gross
    Department of Urology, Case Western Reserve University, Cleveland, OH, USA
    J Physiol 544:679-85. 2002
    ..A homologous motif (D887ADD) in the carboxy-terminus of the anion exchanger AE1 binds to carbonic anhydrase II (CAII)...
  41. ncbi Expression of carbonic anhydrase IV in carbonic anhydrase II-deficient mice
    L P Brion
    Albert Einstein College of Medicine, Department of Pediatrics, Medicine, Bronx, New York 10461, USA
    Am J Physiol 273:F234-45. 1997
    ..This study was designed to assess CA IV expression in a model of CMA in the mouse, i.e., congenital deficiency in CA II [CA(II)D]...
  42. ncbi Carbonic anhydrase II expression pattern in mouse embryonic and fetal heart
    M Vuillemin
    Institute of Histology and Embryology, Lausanne, Switzerland
    Anat Embryol (Berl) 195:267-77. 1997
    b>Carbonic anhydrase II localization was studied in mouse embryonic and fetal hearts for better understanding of the functions of this enzyme during cardiac organogenesis...
  43. ncbi Organization of the mouse and human carbonic anhydrase II genes
    P J Venta
    Ann N Y Acad Sci 429:309-23. 1984
  44. ncbi Cocoa: a new mouse model for platelet storage pool deficiency
    E K Novak
    Roswell Park Memorial Institute, Department of Molecular and Cellular Biology, Buffalo, New York 14263
    Br J Haematol 69:371-8. 1988
    ..Cocoa may be a model for cases of human Hermansky-Pudlak syndrome in which functions of melanosomes and platelet dense granules, but not lysosomes, are involved...
  45. ncbi Structure and exon to protein domain relationships of the mouse carbonic anhydrase II gene
    P J Venta
    J Biol Chem 260:12130-5. 1985
    ..is seen between the regions coded by exons and the functional or secondary structural domains of the mouse CA II molecule...
  46. ncbi Analysis of the mouse Amy locus in recombinant inbred mouse strains
    P R Paul
    Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, Buffalo, New York 14263
    Biochem Genet 25:569-79. 1987
    ..Previously reported differences for strains YBR and CE have been confirmed. New segregation data for carbonic anhydrase, a locus near the proximal end of mouse chromosome 3, are presented...
  47. ncbi Genetic analysis of nonhistone chromosomal protein inheritance in recombinant inbred mouse strains using two-dimensional electrophoresis
    L S Ramagli
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, Houston 77030
    Biochem Genet 28:123-36. 1990
    ..These 16 NHCP genetic marker inheritance differences detected in RIs add to the 23 previously established genetic marker differences between the progenitors...
  48. pmc Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease
    R W Melvold
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611
    J Virol 64:686-90. 1990
    ....
  49. ncbi Cloning of mouse carbonic anhydrase mRNA and its induction in mouse erythroleukemic cells
    P J Curtis
    J Biol Chem 258:4459-63. 1983
    ..Hybridization analysis of poly(A+) RNA from uninduced and induced mouse erythroleukemic cells labeled for short and long time periods indicated that induction results in an increase of carbonic anhydrase mRNA in newly synthesized RNA...
  50. ncbi Biochemical and genetic characterization of esterase-27 (ES-27), the major plasma cholinesterase of the house mouse (Mus musculus)
    O H von Deimling
    Abteilung für Chemische Pathologie, Universitat Freiburg, Bundesrepublik Deutschland
    Genet Res 57:61-70. 1991
    ..From a three-point cross (AKR/Han, A/Wy) and a five-point cross (AKR/Han, SEG/1), the gene order on chromosome 3 was concluded to be centromere-Car-2-Es-26-Es-27-Amy-1-Adh-1...
  51. ncbi Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8
    N Lowe
    Department of Biochemistry, University College London, United Kingdom
    Genomics 10:882-8. 1991
    A cluster of genes encoding the three cytoplasmic carbonic anhydrase isozymes CAI, CAII, and CAIII lie on the long arm of chromosome 8 (8q22) in humans. These genes have been mapped using pulsed-field gel electrophoresis...
  52. ncbi Nucleotide sequence of a cDNA encoding rat brain carbonic anhydrase II and its deduced amino acid sequence
    C A Stolle
    Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick 08903
    Gene 109:265-7. 1991
    A carbonic anhydrase II (CAII)-encoding cDNA clone was isolated from a rat brain lambda gt11 library. The 1459-bp cDNA codes for 260 amino acids with sequence similarity to mouse and human CAII and hybridizes to a single 1.7-kb mRNA.
  53. ncbi Molecular biology of P-glycoprotein
    M M Cornwell
    Cancer Treat Res 57:37-56. 1991
    ..Finally, differential expression of mdr genes encoding P-glycoprotein isoforms with distinct properties appears to be a possible mechanism for generating diversity in MDR rodent cells...
  54. ncbi Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse
    E M Eicher
    Biochem Genet 14:651-60. 1976
    Electrophoretic variants of two carbonic anhydrase enzymes CAR-1 (CA I) and Car-2 (CA II), have been found in the laboratory mouse, Mus musculus...
  55. ncbi Genes on chromosome 3 of the mouse
    M T Davisson
    J Hered 67:155-6. 1976
    ..The Robertsonian translocation Rb(1.3) 1Bnr was used as a marker for the centromere of Chromosome 3. The loci map is as follows: centromere-2.5cM-(Car-1, Car-2)-26cM-my...
  56. pmc Use of two-dimensional electrophoresis to identify and map new mouse genes
    R W Elliott
    Genetics 91:295-308. 1979
    ..These eight genes will be useful reference markers in future crosses designed to map new genes...
  57. ncbi The nucleotide sequence and derived amino acid sequence of cDNA coding for mouse carbonic anhydrase II
    P J Curtis
    Gene 25:325-32. 1983
    ....
  58. ncbi Novel carbonic anhydrase (Car-2) allele in Spanish mice
    J B Whitney
    Biochem Genet 22:913-22. 1984
    ....
  59. ncbi Esterase-26 (ES-26): characterization and genetic location on chromosome 3 of an eserine-sensitive esterase of the house mouse (Mus musculus)
    O H von Deimling
    Biochem Genet 22:1119-26. 1984
    ..The enzyme was shown to be controlled by the presumed structural locus Es-26, located on chromosome 3. From a four-point cross, the gene order Car-2--6.2 +/- 2.7--Es-16--21.0 +/- 4.5--Es-26--13.6 +/- 3.8--Amy-1 was established...
  60. ncbi Carbonic anhydrase II and carbonic anhydrase-related protein in the cerebellar cortex of normal and lurcher mice
    A Nogradi
    Department of Ophthalmology, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    Brain Res Dev Brain Res 98:91-101. 1997
    The developmental profiles of carbonic anhydrase II (CA-II) and a carbonic anhydrase related protein (CARP) were studied in rat and mouse cerebella...
  61. ncbi Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice
    S Breton
    Renal Unit, Massachusetts General Hospital, Boston, USA
    Am J Physiol 269:F761-74. 1995
    The kidneys of mice (CAR2-null mice) that are genetically devoid of carbonic anhydrase type II (CAII) were screened by immunocytochemistry with antibodies that distinguish intercalated and principal cells...
  62. ncbi Reduced susceptibility to seizures in carbonic anhydrase II deficient mutant mice
    L Velisek
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461
    Epilepsy Res 14:115-21. 1993
    The seizure susceptibility of carbonic anhydrase II (CA) deficient mice and their normal littermates was determined and compared...
  63. ncbi Corticotropin-releasing hormone (Crh) maps to mouse chromosome 3
    L T Knapp
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 1618
    Mamm Genome 4:615-7. 1993
  64. ncbi Glial cell abnormalities in the CNS of the carbonic anhydrase II deficient mutant mouse
    W Cammer
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461
    J Neurol Sci 118:1-9. 1993
    The Car-2n/Car-2n mutant mouse is entirely lacking in carbonic anhydrase II (CA), which is normally found in myelin and glial cells in the CNS...
  65. ncbi Membrane-associated CA activity in the eye of the CA II-deficient mouse
    Y Ridderstrale
    Department of Animal Physiology, Swedish University of Agricultural Sciences, Uppsala
    Invest Ophthalmol Vis Sci 35:2577-84. 1994
    ..such histochemical data are difficult to evaluate because of interference from cytoplasmic CA isozymes, of which CA II is predominant...
  66. ncbi Assignment of five loci from human chromosome 8q onto sheep chromosome 9
    T E Broad
    Gene Mapping Unit, AgResearch Grasslands Research Centre, Palmerston North, New Zealand
    Cytogenet Cell Genet 68:102-6. 1995
    Using a chromosomally characterized minipanel of sheep x hamster cell hybrids, five new loci, including carbonic anhydrase II (CA2), calbindin 1 (28 kDa) (CALB1), corticotropin releasing hormone (CRH), cytochrome P450 11B subfamily XIB (..
  67. ncbi Resistance of hippocampal synaptic transmission to hypoxia in carbonic anhydrase II-deficient mice
    L Velisek
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 671:245-53. 1995
    Mutant Car2n/Car2n mice deficient in carbonic anhydrase II (CA II; a major brain CA isozyme) suffer from systemic acidosis and are more resistant to experimental seizures than their normal littermates (+/+ or +/Car2n)...
  68. ncbi Effects of carbonic anhydrase II (CAII) deficiency on CNS structure and function in the myelin-deficient CAII-deficient double mutant mouse
    W Cammer
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci Res 40:451-7. 1995
    In the choroid plexus carbonic anhydrase II (CAII) supports the transport of bicarbonate ions, sodium ions, and water from blood to the CSF, and in the myelin sheath CAII supports compaction of myelin by stimulating cotransport of ions ..
  69. ncbi DNA polymorphism in cytokine genes based on length variation in simple-sequence tandem repeats
    C O Jacob
    Institute of Immunology and Biological Sciences, Syntex Research, Palo Alto, CA 94303
    Immunogenetics 38:251-7. 1993
    ..Advantages of short tandemly repeated sequences as genetic markers are discussed in comparison with RFLPs...
  70. ncbi Genetic analysis of protein variations in Mus musculus using two-dimensional electrophoresis
    R R Racine
    Biochem Genet 18:185-97. 1980
    ..Out of the 100 loci screened, we have found nine loci showing interstrain differences. We have found also that differences in the protein pattern as seen on two-dimensional gels are small among subspecies of Mus musculus...
  71. ncbi Multilocus genomic mapping with intracisternal A-particle proviral oligonucleotide probes hybridized to mouse DNA in dried agarose gels
    K K Lueders
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Electrophoresis 16:179-85. 1995
    ....
  72. ncbi Genotyping new BXD recombinant inbred mouse strains and comparison of BXD and consensus maps
    B A Taylor
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 10:335-48. 1999
    ..Alternatively, recombinant genotypes could be selected against during inbreeding owing to allelic interactions affecting fitness. The latter interpretation implies that relatively strong intrachromosomal epistasis is common...
  73. ncbi Contractile properties of skeletal muscle fibre bundles from mice deficient in carbonic anhydrase II
    Matthew D Beekley
    Zentrum Physiologie, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Pflugers Arch 452:453-63. 2006
    ..contractile properties of extensor digitorum longus (EDL) and soleus (SOL) fibre bundles from mice deficient in CA II (CAD) to litter mate controls (LM)...
  74. ncbi Mapping of mouse carbonic anhydrase-3, Car-3: another locus in the homologous region of mouse chromosome 3 and human chromosome 8
    C Beechey
    MRC Radiobiology Unit, Chilton, Didcot, Oxon, United Kingdom
    Genomics 6:692-6. 1990
    ....
  75. ncbi Glial-cell cultures from brains of carbonic anhydrase II-deficient mutant mice: delay in oligodendrocyte maturation
    W Cammer
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurochem Res 23:407-12. 1998
    b>Carbonic anhydrase II (CAII) is a multifunctional enzyme found in oligodendrocytes and astrocytes in normal mouse brains...
  76. doi Decreased expression of Slc26a4 (Pendrin) and Slc26a7 in the kidneys of carbonic anhydrase II-deficient mice
    Xuming Sun
    Department of Medicine, University of Cincinnati, Cincinnati, OH 45267 0585, USA
    Cell Physiol Biochem 21:95-108. 2008
    Intercalated cells (ICs) of the kidney collecting duct are rich in carbonic anhydrase II (CAII), which facilitates proton and bicarbonate transport...

Research Grants2

  1. CHARACTERIZING SPECIALIZED CHEMOSENSORY NEURONS
    STEVEN MUNGER; Fiscal Year: 2002
    ..In addition, GC-D transgenic mice will be used to examine the ability of neonates to attach to nipples and suckle. ..
  2. Chemosensory receptors and the basis of specificity
    STEVEN MUNGER; Fiscal Year: 2009
    ..abstract_text> ..