Capzb

Summary

Gene Symbol: Capzb
Description: capping protein (actin filament) muscle Z-line, beta
Alias: 1700120C01Rik, AI325129, CPB1, CPB2, CPbeat2, CPbeta1, CPbeta2, Cappb1, F-actin-capping protein subunit beta, capZ beta, capping protein beta 1
Species: mouse

Top Publications

  1. pmc Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth
    David A Davis
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    PLoS Biol 7:e1000208. 2009
  2. ncbi CP beta3, a novel isoform of an actin-binding protein, is a component of the cytoskeletal calyx of the mammalian sperm head
    M von Bülow
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Federal Republic of Germany
    Exp Cell Res 233:216-24. 1997
  3. pmc Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates
    D A Schafer
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 127:453-65. 1994
  4. ncbi Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end
    Marisan R Mejillano
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Cell 118:363-73. 2004
  5. pmc Actin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1
    Francesca Bartolini
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Mol Biol Cell 23:4032-40. 2012
  6. pmc Cyclic mechanical strain of myocytes modifies CapZβ1 post translationally via PKCε
    Ying Hsi Lin
    Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, MC 901, 835 S Wolcott, Chicago, IL, 60612, USA
    J Muscle Res Cell Motil 36:329-37. 2015
  7. doi CKIP-1 regulates mammalian and zebrafish myoblast fusion
    Dominique Baas
    Equipe Différenciation Neuromusculaire, Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5239 ENS Lyon, Universite de Lyon, IFR128 Biosciences Lyon Gerland, 46 allee d Italie, 69364 Lyon Cedex 07, France
    J Cell Sci 125:3790-800. 2012
  8. pmc Capping protein regulatory cycle driven by CARMIL and V-1 may promote actin network assembly at protruding edges
    Ikuko Fujiwara
    Cell Biology and Physiology Center and
    Proc Natl Acad Sci U S A 111:E1970-9. 2014
  9. pmc Capping protein is essential for cell migration in vivo and for filopodial morphology and dynamics
    Shamim A Sinnar
    Division of Biological Sciences, University of California, San Diego, and Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037
    Mol Biol Cell 25:2152-60. 2014
  10. doi Actin-capping proteins play essential roles in the asymmetric division of maturing mouse oocytes
    Yu Jin Jo
    Department of Animal Sciences, Chungbuk National University, Cheong Ju, Chungchungbuk do, 361 763, Republic of Korea
    J Cell Sci 128:160-70. 2015

Scientific Experts

  • P W Marks
  • Giuseppina Mastrototaro
  • Ying Hsi Lin
  • Yu Jin Jo
  • Ikuko Fujiwara
  • Shamim A Sinnar
  • W Glen Pyle
  • Patricia F Kao
  • Feng Hua Yang
  • Dominique Baas
  • Francesca Bartolini
  • Ivana Delalle
  • Akinori Hishiya
  • Taekyung Kim
  • Christopher B Geyer
  • M C Hart
  • David A Davis
  • Raymond F Robledo
  • Jeffrey R Kuhn
  • J A Cooper
  • Xiaoyan Lin
  • John A Cooper
  • Claire E Eyers
  • John Gatfield
  • Marisan R Mejillano
  • Pierluigi Carullo
  • Nam Hyung Kim
  • Woo In Jang
  • Corrado Poggesi
  • Yusu Gu
  • Marie Louise Bang
  • Nicoletta Piroddi
  • Chiara Tesi
  • Farah Sheikh
  • Nancy D Dalton
  • Michael A Mkrtschjan
  • Xingqun Liang
  • Xiaodong Li
  • Brenda Russell
  • Erik R Swanson
  • Suk Namgoong
  • Ju Chen
  • Jieli Li
  • Kirk L Peterson
  • Shelley Halpain
  • Jon A Cooper
  • Jean Michel Saffin
  • John A Hammer
  • Kirsten Remmert
  • Grzegorz Piszczek
  • Susumu Antoku
  • Evelyne Goillot
  • Pierre Jurdic
  • Laurent Schaeffer
  • Jean François Rual
  • PETER R POLGAR
  • Emilie Delaune
  • Gregg G Gundersen
  • Aurélia Vernay
  • Alexandre Guiraud
  • S Palmgren
  • Sabine Caussanel-Boude
  • Stephanie Bertrand
  • Nagendran Ramalingam
  • Fanny Pilot
  • Frederico Calhabeu
  • Charles R Vanderburg
  • Ann C McKee
  • David E Hill
  • Emilie Chopin
  • M Yoshimura
  • Irma Machuca-Gayet
  • Meredith G Banigan
  • Marc Vidal
  • Sudha Seshadri
  • Toshio Kitazawa
  • David Sept
  • Shinichi Takayama
  • Meredith H Wilson
  • Mary Ann Handel
  • Amy L Inselman
  • Li Huei Tsai
  • Zhigang Xie
  • Edward M Eddy
  • Jodel Giraud
  • Sheila Bornstein
  • Jeffrey A Sunman
  • Huang Chun Tseng
  • Cheryl England
  • Haya Herscovitz

Detail Information

Publications28

  1. pmc Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth
    David A Davis
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    PLoS Biol 7:e1000208. 2009
    ..Together, these data suggest that Capzb2 plays an important role in growth cone formation and neurite outgrowth and that the underlying mechanism may involve direct interaction between Capzb2 and microtubules...
  2. ncbi CP beta3, a novel isoform of an actin-binding protein, is a component of the cytoskeletal calyx of the mammalian sperm head
    M von Bülow
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Federal Republic of Germany
    Exp Cell Res 233:216-24. 1997
    ....
  3. pmc Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates
    D A Schafer
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 127:453-65. 1994
    ..Thus, vertebrates have developed isoforms of capping protein that associate with distinct actin-filament arrays...
  4. ncbi Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end
    Marisan R Mejillano
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Cell 118:363-73. 2004
    ....
  5. pmc Actin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1
    Francesca Bartolini
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Mol Biol Cell 23:4032-40. 2012
    ....
  6. pmc Cyclic mechanical strain of myocytes modifies CapZβ1 post translationally via PKCε
    Ying Hsi Lin
    Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, MC 901, 835 S Wolcott, Chicago, IL, 60612, USA
    J Muscle Res Cell Motil 36:329-37. 2015
    ..A hypothetical model is presented proposing that one destination of the mechanotransduction signaling pathways might be for PTMs of CapZ thereby regulating actin capping and filament assembly. ..
  7. doi CKIP-1 regulates mammalian and zebrafish myoblast fusion
    Dominique Baas
    Equipe Différenciation Neuromusculaire, Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5239 ENS Lyon, Universite de Lyon, IFR128 Biosciences Lyon Gerland, 46 allee d Italie, 69364 Lyon Cedex 07, France
    J Cell Sci 125:3790-800. 2012
    ..These results establish CKIP-1 as a regulator of cortical actin that recruits the Arp2/3 complex at the plasma membrane essential for muscle precursor elongation and fusion...
  8. pmc Capping protein regulatory cycle driven by CARMIL and V-1 may promote actin network assembly at protruding edges
    Ikuko Fujiwara
    Cell Biology and Physiology Center and
    Proc Natl Acad Sci U S A 111:E1970-9. 2014
    ..In vivo, therefore, CARMIL should promote Arp2/3-dependent actin network assembly at the leading edge by promoting barbed-end capping there. ..
  9. pmc Capping protein is essential for cell migration in vivo and for filopodial morphology and dynamics
    Shamim A Sinnar
    Division of Biological Sciences, University of California, San Diego, and Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037
    Mol Biol Cell 25:2152-60. 2014
    ..Our results support an expansion of the potential roles that CP plays in cell motility by implicating CP in filopodia as well as in lamellipodia, both of which are important for locomotion in many types of migrating cells. ..
  10. doi Actin-capping proteins play essential roles in the asymmetric division of maturing mouse oocytes
    Yu Jin Jo
    Department of Animal Sciences, Chungbuk National University, Cheong Ju, Chungchungbuk do, 361 763, Republic of Korea
    J Cell Sci 128:160-70. 2015
    ..Taken together, these findings show that capping protein is an essential component of the actin cytoskeleton machinery that plays crucial roles in oocyte maturation, presumably by controlling the cytoplasmic actin mesh density. ..
  11. pmc Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers
    Giuseppina Mastrototaro
    Humanitas Clinical and Research Center, Via Manzoni 113, 20089 Rozzano, Milan, Italy University of Milano Bicocca, Milan, Italy
    Cardiovasc Res 107:216-25. 2015
    ..However, the role of nebulette in vivo has remained elusive. To provide insights into the function of nebulette in vivo, we generated and studied nebulette-deficient (nebl(-) (/-)) mice...
  12. ncbi Dual regulation of mammalian myosin VI motor function
    M Yoshimura
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Ave, Worcester, MA 01655 0127, USA
    J Biol Chem 276:39600-7. 2001
    ..The present results revealed the dual regulation of myosin VI by phosphorylation and Ca(2+) binding to calmodulin light chain...
  13. pmc Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules
    John Gatfield
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 16:2786-98. 2005
    ..The capacity of coronin 1 to link the leukocyte cytoskeleton to the plasma membrane may serve to integrate outside-inside signaling with modulation of the cytoskeleton...
  14. pmc The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ
    Claire E Eyers
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 389:127-35. 2005
    ..Osmotic shock or anisomycin triggered the dissociation of CapZIP from CapZ in Jurkat cells, suggesting that phosphorylation of CapZIP may regulate the ability of CapZ to remodel actin filament assembly in vivo...
  15. pmc Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology
    Patricia F Kao
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Neuropathol Exp Neurol 71:654-64. 2012
    ..In subsequent stages of AD, the higher levels of TrkB and Capzb2 expression achieved may not be sufficient to prevent cognitive decline...
  16. doi Reduced cardiac CapZ protein protects hearts against acute ischemia-reperfusion injury and enhances preconditioning
    Feng Hua Yang
    Cardiovascular Research Group, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Mol Cell Cardiol 52:761-72. 2012
    ..The cardioprotected phenotype of CapZ transgenic mice is associated with an altered translocation of PKC-isoforms to cardiac myofilaments...
  17. pmc Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 112:4298-307. 2008
    ..These data indicate that adducin plays a role in RBC membrane stability and in cerebrospinal fluid homeostasis...
  18. pmc The interaction of capping protein with the barbed end of the actin filament
    Taekyung Kim
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Biol 404:794-802. 2010
    ..These studies provide us with new molecular insight into how CP binds to the actin filament...
  19. pmc BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress
    Akinori Hishiya
    Boston Biomedical Research Institute, Watertown, MA 02472, USA
    Circ Res 107:1220-31. 2010
    ..However, the detailed disease mechanism is not yet fully understood...
  20. pmc A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice
    Christopher B Geyer
    Laboratories of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Dev Biol 330:142-52. 2009
    ..CAPZA3 protein localization was altered in spermatids concurrent with altered localization of a unique CAPZB variant isoform and disruption of the filamentous actin (F-actin) network...
  21. ncbi Single molecule kinetic analysis of actin filament capping. Polyphosphoinositides do not dissociate capping proteins
    Jeffrey R Kuhn
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 282:28014-24. 2007
    ..PPIs binding to this site might interfere sterically with capping, but this site would be inaccessible when CP is bound to the end of a filament...
  22. ncbi Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy
    Xiaoyan Lin
    Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Mol Genet 15:2087-97. 2006
    ..Sequestration of MBNL1, and failure to maintain these splicing transitions, has a pivotal role in the pathogenesis of muscle disease in DM...
  23. ncbi Actin capping protein: an essential element in protein kinase signaling to the myofilaments
    W Glen Pyle
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Ill 60612, USA
    Circ Res 90:1299-306. 2002
    ....
  24. pmc Interactions with PIP2, ADP-actin monomers, and capping protein regulate the activity and localization of yeast twinfilin
    S Palmgren
    Program in Cellular Biotechnology, Institute of Biotechnology, FIN 00014 University of Helsinki, Helsinki, Finland
    J Cell Biol 155:251-60. 2001
    ..Based on these results, we propose a model for the biological role of twinfilin as a protein that localizes actin monomers to the sites of rapid filament assembly in cells...
  25. pmc Mapping of the mouse actin capping protein beta subunit gene
    M C Hart
    Winona State University, Winona, MN 55987, USA
    BMC Genomics 1:1. 2000
    ..Vertebrates have three isoforms of CPbeta produced by alternatively splicing from one gene; lower organisms have one gene and one isoform...
  26. pmc Vertebrate isoforms of actin capping protein beta have distinct functions In vivo
    M C Hart
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 147:1287-98. 1999
    ..These mice showed both myofibril disruption and intercalated disc remodeling, as predicted. Therefore, CPbeta1 and CPbeta2 each have a distinct function that cannot be provided by the other isoform...
  27. ncbi Complete cDNAs for CDC42 from chicken cochlea and mouse liver
    T W Gong
    Kresge Hearing Research Institute, Department of Otolaryngology Head Neck Surgery, Ann Arbor, MI 48109 0648, USA
    Biochim Biophys Acta 1352:282-92. 1997
    ..Cdc42l1 was mapped to distal mouse Chromosome 4, near Cappb1. Cdc42l2 mapped more proximal on Chromosome 4, whereas Cdc42l3 mapped to the X Chromosome.
  28. ncbi Genomic organization and chromosomal location of murine Cdc42
    P W Marks
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genomics 38:13-8. 1996
    ..Using single-strand conformation polymorphism analysis of a mouse backcross panel, the gene encoding cdc42 has been localized to distal chromosome 4...