Genomes and Genes
Gene Symbol: Calca
Description: calcitonin/calcitonin-related polypeptide, alpha
Alias: CGRP-1, CGRP1, Calc, Calc1, Cgrp, Ctn, calcitonin gene-related peptide 1, alpha-type CGRP, calcitonin gene-related peptide I
Publications127 found, 100 shown here
- Calcitonin messenger RNA encodes multiple polypeptides in a single precursorJ W Jacobs
Science 213:457-9. 1981..These findings raise questions concerning the regulation of these cleavages and the potential biological functions of the precursor extensions derived from these cleavages...
- Dynamic regulation of the expression of neurotrophin receptors by Runx3Souichiro Nakamura
Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
Development 135:1703-11. 2008..Moreover, we show that the number of TrkA-positive DRG neurons is reduced in Runx3(-/-) mice, as compared with the wild type. These results suggest that Runx3 positively regulates the expression of TrkC and TrkA in DRG neurons...
- Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neuronsE Bloch-Gallego
Institut National de la Santé et de la Recherche Médicale U106, Hopital de la Salpetriere, 75013 Paris, France
J Neurosci 19:4407-20. 1999..They also establish a requirement for netrin-1, either directly or indirectly, for the survival of inferior olivary neurons...
- Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neuronsK Matsumoto
Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283 8555, Japan
Neuroscience 172:518-34. 2011..Numerous TRPV1 and calcitonin gene-related peptide (CGRP) immunoreactivities were detected, mainly in the mucosa, submucosal layer, and myenteric plexus...
- Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouseA Ahluwalia
Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London, UK
Eur J Pharmacol 264:407-15. 1994..Endogenous calcitonin gene-related peptide (CGRP) was found to be involved as a mediator of interleukin-1 beta (5 ng)-induced migration, since the CGRP receptor ..
- Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous systemK F Lee
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142
Cell 69:737-49. 1992..Our results suggest that p75NGFR has an important role in the development and function of sensory neurons...
- The role of Hoxa-3 in mouse thymus and thyroid developmentN R Manley
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
Development 121:1989-2003. 1995..This variability suggests the presence of a compensating gene or genes, whose utilization is stochastic. A reasonable candidate for providing this compensatory function is the paralogous gene Hoxb-3...
- Requirement for Brn-3.0 in differentiation and survival of sensory and motor neuronsR J McEvilly
Howard Hughes Medical Institute, University of California, San Diego, USA
Nature 384:574-7. 1996..Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations...
- An achaete-scute homologue essential for neuroendocrine differentiation in the lungM Borges
The Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Nature 386:852-5. 1997....
- Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glandsN R Manley
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112 5331
Dev Biol 195:1-15. 1998..This unique function may be conferred by the expression of Hoxa3, but not Hoxb3 nor Hoxd3, in the pharyngeal pouch endoderm...
- Follicular cells of the thyroid gland require Pax8 gene functionA Mansouri
MPI of Biophysical Chemistry, Dept of Molecular Cell Biology, Gottingen, Germany
Nat Genet 19:87-90. 1998..We present evidence that Pax8 is necessary for providing cues for the differentiation of competent endoderm primordia into thyroxin-producing follicular cells...
- Modulation of morphine analgesia in alphaCGRP mutant miceA M Salmon
CNRS UA D1284 Neurobiologie Moleculaire, Institut Pasteur, Paris, France
Neuroreport 10:849-54. 1999A homozygous CGRP-/- mouse line was generated by the targeted disruption of exon 5 in the calcitonin/alphaCGRP gene using homologous recombination. The mutant mice lack alphaCGRP mRNA...
- Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epitheliumT Ito
Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
Development 127:3913-21. 2000..Thus, the neuroendocrine differentiation depends on basic helix-loop-helix factors, and Notch/Notch-ligand pathways may be involved in determining the cell differentiation fate in fetal airway epithelium...
- Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivityL Zhang
Department of Anatomy and Neurosciences, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1069, USA
Pain 89:265-73. 2001..released from nerve terminals, including amino acids, substance P (SP) and calcitonin gene-related peptide (CGRP)...
- A TRP channel that senses cold stimuli and mentholAndrea M Peier
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
Cell 108:705-15. 2002..Our identification of a cold-sensing TRP channel in a distinct subpopulation of sensory neurons implicates an expanded role for this family of ion channels in somatic sensory detection...
- Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroidPin Xian Xu
McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
Development 129:3033-44. 2002..5 in Eya1(-/-) embryos. Our results indicate that Eya1 controls critical early inductive events involved in the morphogenesis of thymus, parathyroid and thyroid...
- Effect of Brn-3a deficiency on parvalbumin-, calbindin D-28k-, calretinin- and calcitonin gene-related peptide-immunoreactive primary sensory neurons in the trigeminal ganglionH Ichikawa
Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
Neuroscience 113:537-46. 2002Immunohistochemistry for parvalbumin, calbindin D-28k, calretinin and calcitonin gene-related peptide (CGRP) was performed on the trigeminal ganglion and oro-facial tissues in Brn-3a wildtype and knockout mice at embryonic day 18...
- Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neuronsKen ichi Inoue
Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
Nat Neurosci 5:946-54. 2002..Our data demonstrate that Runx3 is critical in regulating the axonal projections of a specific subpopulation of DRG neurons...
- Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptideThorsten Schinke
Department of Trauma, Hand, and Reconstructive Surgery, Hamburg University School of Medicine, Martinistrasse 52, Hamburg 20246, Germany
J Bone Miner Res 19:2049-56. 2004We recently described an unexpected high bone mass phenotype in mice lacking the Calca gene that encodes CT and alphaCGRP...
- A developmental switch in the response of DRG neurons to ETS transcription factor signalingSimon Hippenmeyer
Biozentrum, Department of Cell Biology, University of Basel, Switzerland
PLoS Biol 3:e159. 2005..Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation...
- The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulationHenrik Fagman
Institute of Anatomy and Cell Biology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Dev Dyn 235:444-55. 2006..It is suggested that thyroid inductive signals arise from embryonic vessels, and that this provides ideas to conceptually new pathogenetic mechanisms of thyroid dysgenesis...
- Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroidTakashi Kusakabe
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Dev Dyn 235:1300-9. 2006..1 expression. These results demonstrate that T/ebp/Nkx2.1 plays a role in the survival of UBB cells, their dissemination into the thyroid diverticulum, and the formation of UBB-derived vesicular structure...
- Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic painChih Li Chen
Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
Neuron 49:365-77. 2006..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy...
- A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversificationIna Kramer
Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Neuron 49:379-93. 2006..contrast, Runx1 controls neuronal diversification within Ngn1-dependent TrkA+ neurons by repression of neuropeptide CGRP expression and controlling the fine pattern of laminar termination in the dorsal spinal cord...
- Mash1 regulates the development of C cells in mouse thyroid glandsYoko Kameda
Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
Dev Dyn 236:262-70. 2007..The C cells of newborn mice are immunoreactive for calcitonin, calcitonin gene-related peptide (CGRP), protein gene product (PGP) 9...
- Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivoJian Zhong
Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7250, USA
Nat Neurosci 10:598-607. 2007..We conclude that Raf function is crucial for several aspects of DRG neuron development, including differentiation and axon growth...
- A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neuronsWenqin Luo
The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 54:739-54. 2007..These findings support a model in which NGF controls maturation of nonpeptidergic DRG neurons through a combination of GFR/Ret-dependent and -independent signaling pathways...
- Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICERMarit D Harzenetter
Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, Munich, Germany
J Immunol 179:607-15. 2007..the nervous and immune systems involves the release of neuropeptides, such as calcitonin gene-related peptide (CGRP), from sensory nerves during inflammation...
- Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine developmentYoko Kameda
Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
J Histochem Cytochem 55:1075-88. 2007..These results indicated that murine thyroid C cells are derived from the endodermal epithelial cells of the fourth pharyngeal pouch and do not originate from neural crest cells...
- Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potentialJianghui Meng
International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin 9, Ireland
J Cell Sci 120:2864-74. 2007Calcitonin-gene-related peptide (CGRP), a potent vasodilator that mediates inflammatory pain, is elevated in migraine; nevertheless, little is known about its release from sensory neurons...
- Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient miceKazutake Tsujikawa
Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
Proc Natl Acad Sci U S A 104:16702-7. 2007Calcitonin gene-related peptide (CGRP) is thought to be a prominent neuropeptide in cardiovascular regulation and neuroimmune modulation...
- The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cordHannes Schmidt
Max Delbruck Centrum fur Molekulare Medizin, Berlin D 13092, Germany
J Cell Biol 179:331-40. 2007..Hence, our data demonstrate that Npr2 and cGKI are essential constituents of the signaling pathway underlying axonal bifurcation at the DREZ and neuronal connectivity in the dorsal spinal cord...
- Distinct chemical classes of medium-sized transient receptor potential channel vanilloid 1-immunoreactive dorsal root ganglion neurons innervate the adult mouse jejunum and colonL L Tan
Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
Neuroscience 156:334-43. 2008..size and expression patterns of transient receptor potential vanilloid 1 (TRPV1), calcitonin gene-related peptide (CGRP), substance P (SP), neuronal nitric oxide synthase (NOS) and isolectin B4-binding (IB4) in dorsal root ganglion (..
- Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptideMasaya Toda
Departments of Pharmacology and Anesthesiology, Kitasato University School of Medicine, Kanagawa 228 8555, Japan
Proc Natl Acad Sci U S A 105:13550-5. 2008A neuropeptide, calcitonin gene-related peptide (CGRP), is widely distributed in neuronal systems and exhibits numerous biological activities...
- Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP miceHiroshi Hasegawa
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Comp Neurol 511:543-56. 2008..Our results revealed the subtype identities of TrkC-positive mechanosensory neurons and demonstrated the usefulness of HS3ST-2 as a genetic marker for these subclasses of neurons...
- FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymusYoko Kameda
Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
Dev Dyn 238:503-13. 2009..Thus, the separation, migration, and survival of the pharyngeal organs were impaired in the FRS2alpha(2F/2F) mutants...
- Notch signaling controls the balance of ciliated and secretory cell fates in developing airwaysPo Nien Tsao
Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Development 136:2297-307. 2009..It might also be relevant to mediate the metaplastic changes in the respiratory epithelium that occur in pathological conditions, such as asthma and chronic obstructive pulmonary disease...
- Lunatic Fringe-mediated Notch signaling is required for lung alveogenesisKeli Xu
Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College St, East Tower, Rm 14 309, Toronto, Ontario, Canada M5G 1L7
Am J Physiol Lung Cell Mol Physiol 298:L45-56. 2010..In sum, these results demonstrate that Lfng functions to enhance Notch signaling in myofibroblast precursor cells and thereby to coordinate differentiation and mobilization of myofibroblasts required for alveolar septation...
- Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fateMitsuru Morimoto
Department of Developmental Biology and Division of Dermatology, Washington University School of Medicine, Box 8103, Saint Louis, MO 63110 1095, USA
J Cell Sci 123:213-24. 2010..These analyses suggest that the impact of gamma-secretase inhibitors on branching in vitro reflect a non-cell autonomous contribution from endothelial or vSMC-derived signals...
- Signaling via Alk5 controls the ontogeny of lung Clara cellsYiming Xing
Department of Pediatrics, Division of Neonatology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
Development 137:825-33. 2010..Thus, the signaling pathway by which TGFbeta/ALK5 regulates Clara cell differentiation may entail inhibition of Pten expression, which in turn activates ERK and AKT phosphorylation...
- Hepatocyte growth factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neuronsEduardo Gascon
Institut de Biologie du Developpement de Marseille Luminy, Unite Mixte de Recherche 6216, Centre National de la Recherche Scientifique Université de la Méditerranée, 13288 Marseille, France
J Neurosci 30:12414-23. 2010..derived from the RUNX1 lineage, require Met activity for the proper extinction of Runx1 and optimal activation of CGRP (calcitonin gene-related peptide)...
- An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebratesTing Guo
Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Neurosci 14:31-6. 2011..Thus, conserved growth factors control divergent neuronal transcriptional events that mediate interspecies differences in neural circuits and the behaviors that they control...
- Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neuronsDaniel J Cavanaugh
Departments of Anatomy, University of California, San Francisco, California 94158, USA
J Neurosci 31:10119-27. 2011....
- CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itchEric S McCoy
Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS ONE 7:e36355. 2012Calcitonin gene-related peptide (CGRPα, encoded by Calca) is a classic marker of nociceptive dorsal root ganglia (DRG) neurons. Despite years of research, it is unclear what stimuli these neurons detect in vitro or in vivo...
- Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airwaysArjun Guha
Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Proc Natl Acad Sci U S A 109:12592-7. 2012....
- Calcitonin gene-related peptide and cyclic adenosine 5'-monophosphate/protein kinase A pathway promote IL-9 production in Th9 differentiation processNorihisa Mikami
Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565 0871, Japan
J Immunol 190:4046-55. 2013..investigated one of the physiological mediators derived from the nervous system, calcitonin gene-related peptide (CGRP), in asthma and Th9 cells because CGRP and activation of the cAMP/protein kinase A (PKA) pathway by CGRP are known ..
- Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to coldEric S McCoy
Department of Cell Biology and Physiology, UNC Neuroscience Center, The University of North Carolina at Chapel Hill, CB 7545, Chapel Hill, NC 27599, USA
Neuron 78:138-51. 2013Calcitonin gene-related peptide (CGRP) is a classic molecular marker of peptidergic primary somatosensory neurons. Despite years of research, it is unknown whether these neurons are required to sense pain or other sensory stimuli...
- Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired sucklingM Xiang
Department of Molecular Biology, Johns Hopkins University School Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 93:11950-5. 1996....
- Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient miceA M Salmon
CNRS URA 2182, Neurobiologie moleculaire, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Nat Neurosci 4:357-8. 2001The neuropeptide alpha CGRP (calcitonin gene-related peptide) is involved in the complex process of pain signaling, but the precise contribution of alpha CGRP remains unclear...
- Analysis of the cellular expression pattern of beta-CGRP in alpha-CGRP-deficient miceBurkhard Schütz
Laboratory of Molecular Neurobiology, Clinic for Psychiatry, University Medical Center, 53127 Bonn, Germany
J Comp Neurol 476:32-43. 2004..b>CGRP immunoreactivity (IR) was detected in many small and some large neurons in the dorsal root ganglia, was found in ..
- Variable sensitivity to noxious heat is mediated by differential expression of the CGRP geneJeffrey S Mogil
Department of Psychology and Centre for Research on Pain, McGill University, Montreal, QC, Canada H3A 1B1
Proc Natl Acad Sci U S A 102:12938-43. 2005..Linkage mapping supports the contention that the genetic variant determining variable heat pain sensitivity across mouse strains affects the expression of the Calca gene that codes for CGRPalpha.
- Many major CNS axon projections develop normally in the absence of semaphorin IIIS M Catalano
Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, 94720 3200, USA
Mol Cell Neurosci 11:173-82. 1998..Our data lead us to suggest that if Sema III functions in part to guide the formation of major axonal projections, then it does so in combination with both other semaphorins and other families of guidance molecules...
- A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervationB T Fundin
Laboratory of Molecular Neurobiology, MBB, Karolinska Institute, S171 77 Stockholm, Sweden
Development 126:2597-610. 1999....
- Essential function of oncostatin m in nociceptive neurons of dorsal root gangliaYoshihiro Morikawa
Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, 641 8509 Japan
J Neurosci 24:1941-7. 2004..Thus, OSM plays an essential role in the development of a subtype of nociceptive neurons in the DRGs...
- Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 geneXiang Jun Chen
Jack Miller Center for Peripheral Neuropathy and Department of Neurology, The University of Chicago, Chicago, Illinois 60637, USA
J Neurosci 27:14515-24. 2007..Together, we provide in vivo evidence that distinct mutations in cytoplasmic dynein can either result in a pure sensory neuropathy or in a sensory neuropathy with motor neuron involvement...
- DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brainMing Shi
Institute of Neuroscience and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Mol Cell Neurosci 39:529-38. 2008..Thus, our findings demonstrate that DCC is a key regulator of tangential migration of LC neurons during the embryonic development...
- C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neuronsHannes Schmidt
Department of Developmental Neurobiology, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin, Germany
Proc Natl Acad Sci U S A 106:16847-52. 2009..Functionally, the bifurcation error in CNP mutant mice is maintained at mature stages and results in a reduced input on secondary neurons as detected by patch-clamp recordings...
- Cilostazol improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampusJuan Zhao
Departments of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
Neuropharmacology 58:774-83. 2010..Cilostazol increased the release of calcitonin gene-related peptide (CGRP) and levels of cAMP in dorsal root ganglion (DRG) neurons isolated from wild-type (WT) mice...
- Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesityChristopher S Walker
School of Biological Sciences, University of Auckland, Private Bag 92 019, Auckland 1142, New Zealand
Endocrinology 151:4257-69. 2010..These findings define a new role for alphaCGRP as a mediator of energy metabolism and opens up therapeutic opportunities to target CGRP action in obesity.
- An ongoing role of α-calcitonin gene-related peptide as part of a protective network against hypertension, vascular hypertrophy, and oxidative stressSarah Jane Smillie
Cardiovascular Division, King s College London, Franklin Wilkins Building, London, SE1 9NH, United Kingdom
Hypertension 63:1056-62. 2014Calcitonin gene-related peptide (αCGRP) is a vasodilator, but there is limited knowledge of its long-term cardiovascular protective influence...
- Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociceptionNora E Szabo
Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
J Neurosci 35:5233-46. 2015..Together, our results demonstrate an important role for the intersection of Lmx1b and Hoxb8::cre expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal pain processing. ..
- Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPα transgenic reporter mouseTimothy J Hibberd
Discipline of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia and
Am J Physiol Gastrointest Liver Physiol 310:G561-73. 2016..A transgenic calcitonin gene-related peptide-α (CGRPα)-mCherry reporter mouse, which enabled rapid identification of soma neurochemistry and morphology following ..
- Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system developmentL Erkman
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093, USA
Nature 381:603-6. 1996..Mutation of Brn-3.1 results in complete deafness, owing to a failure of hair cells to appear in the inner ear, with subsequent loss of cochlear and vestibular ganglia...
- Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesisPeng Li
Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California Keck School of Medicine, 1425 San Pablo St, Los Angeles, CA 90033, USA
Dev Biol 361:116-24. 2012....
- Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptorsClaudia Lopes
Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 32:9706-15. 2012..Collectively, these studies suggest that genetically Tlx3 acts in combination with Runx1 to control the development of a cohort of nociceptors, thermoceptors, and pruriceptors in mice...
- Enhancement of CGRP sensory afferent innervation in the gut during the development of food allergy in an experimental murine modelJaemin Lee
Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
Biochem Biophys Res Commun 430:895-900. 2013..Calcitonin gene-related peptide (CGRP) is exclusively contained in intrinsic and extrinsic primary afferent neurons in the mouse intestine...
- Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung developmentYadi Huang
Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
PLoS ONE 8:e57695. 2013..Moreover, Hif3α affected the expression of genes not typically involved in the hypoxia response, providing evidence for a novel function of Hif3α beyond the hypoxia response...
- Peripherally administered calcitonin gene-related peptide decreases food intake in miceJ E Morley
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, St Louis, MO 63106, USA
Peptides 17:511-6. 1996Previously, calcitonin gene-related peptide (CGRP) decreased food intake when administered ICV but not when administered peripherally to rats...
- Dopamine neuron agenesis in Nurr1-deficient miceR H Zetterström
Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
Science 276:248-50. 1997..These results suggest that putative Nurr1 ligands may be useful for treatment of Parkinson's disease and other disorders of midbrain dopamine circuitry...
- Localization of calcitonin gene-related peptide mRNA in developing olfactory axonsS Denis-Donini
Department of Biology, University of Milan, Via Celoria 26, I 20133 Milan, Italy
Cell Tissue Res 294:81-91. 1998During development of the olfactory pathway, calcitonin gene-related peptide (CGRP) expression is regulated both temporally and spatially...
- Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular developmentJ T Lu
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Mol Cell Neurosci 14:99-120. 1999..b>CGRP has been implicated in a variety of physiological processes including peripheral vasodilation, cardiac acceleration ..
- Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gutH M Young
Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia
Dev Dyn 216:137-52. 1999..Calcitonin gene-related peptide (CGRP) neurons showed Phox2b and Ret-immunoreactivity, but not Phox2a immunoreactivity...
- Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projectionsH J Cheng
Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143 0452, USA
Neuron 32:249-63. 2001..Analysis of plexin-A3 knockout mice shows that plexin-A3 contributes to Sema3F and Sema3A signaling and that plexin-A3 regulates the development of hippocampal axonal projections in vivo...
- Developmental timing of hair follicle and dorsal skin innervation in miceEva M J Peters
Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg D 20246, Germany
J Comp Neurol 448:28-52. 2002..This sequence of developing innervation consistently correlates with hair follicle development, indicating a close interdependence of neuronal and epithelial morphogenesis...
- Sim2 mutants have developmental defects not overlapping with those of Sim1 mutantsEleni Goshu
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Mol Cell Biol 22:4147-57. 2002..The temporal and spatial expression patterns of Sim2 in these skeletal elements suggest that Sim2 regulates their growth and/or integrity...
- Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neuronsPontus C Holm
Department of Medical Biochemistry and Biophysics, Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm S 171 77, Sweden
Development 130:3535-45. 2003..In summary, our findings suggest that, unlike NT3 and GDNF, TrkB ligands are required and sufficient to promote the development of central noradrenergic neurons...
- Neuropeptides concentrations in the skin of a murine (NC/Nga mice) model of atopic dermatitisMasako Katsuno
Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa, Yokohama, Japan
J Dermatol Sci 33:55-65. 2003..It has been reported that the expression of neuropeptides (NPs), and the density and structure of peripheral nerves in atopic dermatitis (AD) are different from those in normal skin...
- Reduction of withdrawal signs after chronic nicotine exposure of alpha-calcitonin gene-related peptide knock-out miceAnne Marie Salmon
CNRS UA D 1284 Récepteurs et Cognition, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Neurosci Lett 360:73-6. 2004..We report that these animals develop a normal tolerance to the antinociceptive effects of nicotine, but display an attenuation of somatic withdrawal symptoms...
- Distribution of calcitonin gene-related peptide at the neuromuscular junction of mdx miceMaria Julia Marques
Department of Anatomy, Institute of Biology, State University of Campinas, Campinas, Sao Paulo, Brazil
Anat Rec A Discov Mol Cell Evol Biol 279:798-803. 2004..One such factor is calcitonin gene-related peptide (CGRP), which has been implicated in AChR synthesis and function...
- Differential expression of calcitonin gene-related peptide (CGRP) and choline acetyltransferase (ChAT) in the axotomized motoneurons of normoxic and hypoxic ratsHung Ming Chang
Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 1, Section 1, Jen Ai Road, Taipei 100, Taiwan
J Chem Neuroanat 28:239-51. 2004..to determine how nerve injury and hypoxic insult would affect the expression of calcitonin gene-related peptide (CGRP) and choline acetyltransferase (ChAT) in the hypoglossal nucleus (HN) and nucleus ambiguus (NA)...
- Calcitonin gene-related peptide protects against hypertension-induced heart and kidney damageScott C Supowit
Texas A and M University System Health Science Center, Temple, TX, USA
Hypertension 45:109-14. 2005..These data suggest that deletion of the alpha-calcitonin gene-related peptide gene makes the heart and kidneys more vulnerable to hypertension-induced end organ damage...
- Targeted overexpression of calcitonin in gonadotrophs of transgenic mice leads to chronic hypoprolactinemiaRen Yuan
Department of Pharmaceutical Sciences, University of Louisiana School of Pharmacy, 700 University Avenue, Monroe, LA 71209, USA
Mol Cell Endocrinol 229:193-203. 2005....
- The location and phenotype of proliferating neural-crest-derived cells in the developing mouse gutH M Young
Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia
Cell Tissue Res 320:1-9. 2005..5). Thus, for enteric neurons, exit from the cell cycle appears to occur after the expression of pan-neuronal proteins but prior to the expression of markers of terminally differentiated neurons...
- Brn-3a is required for the generation of proprioceptors in the mesencephalic trigeminal tract nucleusH Ichikawa
Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
Brain Res 1053:203-6. 2005..The present study suggests that Brn-3a is required for the development of proprioceptors but not motoneurons in the trigeminal nervous system...
- Phenotypes of neural-crest-derived cells in vagal and sacral pathwaysR B Anderson
Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia
Cell Tissue Res 323:11-25. 2006....
- Increased progenitor proliferation and apoptotic cell death in the sensory lineage of mice overexpressing N-mycMiwako Kobayashi
Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheelesv 1, 171 77 Stockholm, Sweden
Cell Tissue Res 323:81-90. 2006....
- Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cordS A Villeda
Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
Neuroscience 139:1385-96. 2006..As the nociceptors in control and reeler dorsal root ganglia are similar, our results indicate that Reelin signaling is an essential contributor to the normal development of central circuits that underlie nociceptive processing and pain...
- Prenatal development of transient receptor potential vanilloid 1-expressing primary sensory projections to sacral autonomic preganglionic neuronsKengo Funakoshi
Department of Neuroanatomy, Yokohama City University School of Medicine, 3 9 Fukuura, Yokohama, Japan
Neurosci Lett 407:230-3. 2006..Thus, the functional circuit for pelvic spinal reflexes, such as micturition induced by urine influx, might develop in the prenatal stages in mice...
- Calcitonin deficiency in mice progressively results in high bone turnoverAntje K Huebner
Center for Biomechanics and Skeletal Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Bone Miner Res 21:1924-34. 2006..Unexpectedly, Calca-deficient mice lacking CT and alpha-calcitonin gene-related peptide (alphaCGRP) were described to have a high bone ..
- Contribution of sensory neurons to sex difference in the development of stress-induced gastric mucosal injury in miceNobuhiko Shimozawa
Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan
Gastroenterology 131:1826-34. 2006..a critical role in reducing stress-induced gastric mucosal injury by releasing calcitonin gene-related peptide (CGRP) through an increase in gastric mucosal levels of prostacyclin (PGI(2))...
- The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioningH Fagman
Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy at Goteborg University, SE 40530, Goteborg, Sweden
Hum Mol Genet 16:276-85. 2007..Thyroid dysgenesis related to Tbx1 inactivation may explain an overrepresentation of hypothyroidism occurring in patients with the 22q11DS...
- Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesisAlice T Shaw
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston 02114, USA
Genes Dev 21:694-707. 2007..These findings indicate that in the lung, Sprouty-2 plays a critical role in the regulation of oncogenic K-ras, and implicate counter-regulatory mechanisms in the pathogenesis of Ras-based disease...
- Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11Cheng Zhong Wang
Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Mol Cell Neurosci 35:368-76. 2007..Taken together, our results demonstrate an essential role for Drg11 in the development of the Me5...
- A transient unresponsive state of self-scratching behaviour is induced in mice by skin-scratching stimulationJunichi Yamaoka
Department of Dermatology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo, Japan
Exp Dermatol 16:737-45. 2007..Pretreatment with a calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37) did not affect the following self-scratching behaviour...
- Deletion of the mouse alpha-calcitonin gene-related peptide gene increases the vulnerability of the heart to ischemia-reperfusion injuryRuiping Huang
Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA
Am J Physiol Heart Circ Physiol 294:H1291-7. 2008Calcitonin gene-related peptide (CGRP), a potent vasodilator released from capsaicin-sensitive C-fiber and Adelta-fiber sensory nerves, has been suggested to play a beneficial role in myocardial ischemia-reperfusion (I/R) injury...
- Calcitonin gene-related peptide biases Langerhans cells toward Th2-type immunityWanhong Ding
Department of Dermatology, Weill Cornell Medical College, New York, NY 10021, USA
J Immunol 181:6020-6. 2008..LC are associated with nerves containing the neuropeptide calcitonin gene-related peptide (CGRP), and CGRP inhibits LC Ag-presentation in several models including presentation to a Th1 clone...
- Calcitonin induces expression of the inducible cAMP early repressor in osteoclastsMaobin Yang
Department of Medicine, MC 1850, University of Connecticut Health Center, 263 Farmington Avenue, Farmington 06030, CT, USA
Endocrine 33:245-53. 2008..Furthermore, calcitonin decreased calcitonin receptor mRNA expression in wildtype osteoclasts, but not in Crem knockout osteoclasts. These data suggest that calcitonin induction of ICER in osteoclasts might regulate osteoclast activity...
- Calcitonin gene-related peptide (CGRP) triggers Ca2+ responses in cultured astrocytes and in Bergmann glial cells from cerebellar slicesStefano Morara
C N R, Institute of Neuroscience, Via Privata Bianco 9, 20131 Milan, Italy
Eur J Neurosci 28:2213-20. 2008The neuropeptide calcitonin gene-related peptide (CGRP) is transiently expressed in cerebellar climbing fibers during development while its receptor is mainly expressed in astrocytes, in particular Bergmann glial cells...
- Pre-symptomatic alterations in subcellular betaCGRP distribution in motor neurons precede astrogliosis in ALS miceCornelia Ringer
Department of Molecular Neurosciences, Institute of Anatomy and Cell Biology, Philipps University, Robert Koch Strabetae 8, Marburg D 35032, Germany
Neurobiol Dis 35:286-95. 2009In our study we investigated the pathology-related expression patterns of the two calcitonin gene-related peptide (CGRP) isoforms in spinal cord motor neurons of SOD1(G93A) mice, an animal model of the human motor neuron disease, ..
- Low affinity NGF receptor (p75 neurotrophin receptor) inhibitory antibody reduces pain behavior and CGRP expression in DRG in the mouse sciatic nerve crush modelYu Fukui
Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
J Orthop Res 28:279-83. 2010..we examined suppression of pain behavior and expression of neuropeptides such as calcitonin gene-related peptide (CGRP) using a p75 NTR inhibitory antibody, in a mouse sciatic nerve crush model...
- Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signalingSteeve Bourane
INSERM U 583, F34091 Montpellier, France
Neuron 64:857-70. 2009..Our results provide evidence that genetic interactions involving Ret and MafA progressively promote the differentiation and diversification of LTMs...
- Gene Transfer to the Inner EarAnne Luebke; Fiscal Year: 2003..Information gained from these studies will aid development of theraupeutic strategies targeted at genes involved in deafness. ..
- MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORSAnne Luebke; Fiscal Year: 2009..In this next project period, we will focus on the LOC efferent fibers that contain calcitonin gene-related peptide (CGRP)...
- Biochemical Modulation of Nociceptive CircuitsMARK JOHN ZYLKA; Fiscal Year: 2010..Finally, we will test the hypothesis that this phosphatase modulates neuropathic pain behaviors in wild-type and phosphatase knockout mice. ..
- PROGESTERONE RECEPTOR IN BREAST DEVELOPMENT AND CANCERJohn Lydon; Fiscal Year: 2008..unreadable] [unreadable]..
- Roles for HIC1 in neural development and tumor suppressionDAVID NEIL WATKINS; Fiscal Year: 2010..These findings are of direct relevance to many cancers, since deregulation of pathways known to be important in embryonic development can help us understand the basis of human malignancy. ..
- Gene expression networks for metabolic syndrome traits in miceThomas A Drake; Fiscal Year: 2010....