Calca

Summary

Gene Symbol: Calca
Description: calcitonin/calcitonin-related polypeptide, alpha
Alias: CGRP-1, CGRP1, Calc, Calc1, Cgrp, Ctn, calcitonin gene-related peptide 1, alpha-type CGRP, calcitonin gene-related peptide I
Species: mouse

Top Publications

  1. ncbi Calcitonin messenger RNA encodes multiple polypeptides in a single precursor
    J W Jacobs
    Science 213:457-9. 1981
  2. doi Dynamic regulation of the expression of neurotrophin receptors by Runx3
    Souichiro Nakamura
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
    Development 135:1703-11. 2008
  3. ncbi Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons
    E Bloch-Gallego
    Institut National de la Santé et de la Recherche Médicale U106, Hopital de la Salpetriere, 75013 Paris, France
    J Neurosci 19:4407-20. 1999
  4. doi Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons
    K Matsumoto
    Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283 8555, Japan
    Neuroscience 172:518-34. 2011
  5. ncbi Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse
    A Ahluwalia
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London, UK
    Eur J Pharmacol 264:407-15. 1994
  6. ncbi Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
    K F Lee
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142
    Cell 69:737-49. 1992
  7. ncbi The role of Hoxa-3 in mouse thymus and thyroid development
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Development 121:1989-2003. 1995
  8. ncbi Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons
    R J McEvilly
    Howard Hughes Medical Institute, University of California, San Diego, USA
    Nature 384:574-7. 1996
  9. ncbi An achaete-scute homologue essential for neuroendocrine differentiation in the lung
    M Borges
    The Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nature 386:852-5. 1997
  10. ncbi Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112 5331
    Dev Biol 195:1-15. 1998

Research Grants

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. ncbi Calcitonin messenger RNA encodes multiple polypeptides in a single precursor
    J W Jacobs
    Science 213:457-9. 1981
    ..These findings raise questions concerning the regulation of these cleavages and the potential biological functions of the precursor extensions derived from these cleavages...
  2. doi Dynamic regulation of the expression of neurotrophin receptors by Runx3
    Souichiro Nakamura
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
    Development 135:1703-11. 2008
    ..Moreover, we show that the number of TrkA-positive DRG neurons is reduced in Runx3(-/-) mice, as compared with the wild type. These results suggest that Runx3 positively regulates the expression of TrkC and TrkA in DRG neurons...
  3. ncbi Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons
    E Bloch-Gallego
    Institut National de la Santé et de la Recherche Médicale U106, Hopital de la Salpetriere, 75013 Paris, France
    J Neurosci 19:4407-20. 1999
    ..They also establish a requirement for netrin-1, either directly or indirectly, for the survival of inferior olivary neurons...
  4. doi Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons
    K Matsumoto
    Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283 8555, Japan
    Neuroscience 172:518-34. 2011
    ..Numerous TRPV1 and calcitonin gene-related peptide (CGRP) immunoreactivities were detected, mainly in the mucosa, submucosal layer, and myenteric plexus...
  5. ncbi Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse
    A Ahluwalia
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London, UK
    Eur J Pharmacol 264:407-15. 1994
    ..Endogenous calcitonin gene-related peptide (CGRP) was found to be involved as a mediator of interleukin-1 beta (5 ng)-induced migration, since the CGRP receptor ..
  6. ncbi Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
    K F Lee
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142
    Cell 69:737-49. 1992
    ..Our results suggest that p75NGFR has an important role in the development and function of sensory neurons...
  7. ncbi The role of Hoxa-3 in mouse thymus and thyroid development
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Development 121:1989-2003. 1995
    ..This variability suggests the presence of a compensating gene or genes, whose utilization is stochastic. A reasonable candidate for providing this compensatory function is the paralogous gene Hoxb-3...
  8. ncbi Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons
    R J McEvilly
    Howard Hughes Medical Institute, University of California, San Diego, USA
    Nature 384:574-7. 1996
    ..Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations...
  9. ncbi An achaete-scute homologue essential for neuroendocrine differentiation in the lung
    M Borges
    The Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nature 386:852-5. 1997
    ....
  10. ncbi Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112 5331
    Dev Biol 195:1-15. 1998
    ..This unique function may be conferred by the expression of Hoxa3, but not Hoxb3 nor Hoxd3, in the pharyngeal pouch endoderm...
  11. ncbi Follicular cells of the thyroid gland require Pax8 gene function
    A Mansouri
    MPI of Biophysical Chemistry, Dept of Molecular Cell Biology, Gottingen, Germany
    Nat Genet 19:87-90. 1998
    ..We present evidence that Pax8 is necessary for providing cues for the differentiation of competent endoderm primordia into thyroxin-producing follicular cells...
  12. ncbi Modulation of morphine analgesia in alphaCGRP mutant mice
    A M Salmon
    CNRS UA D1284 Neurobiologie Moleculaire, Institut Pasteur, Paris, France
    Neuroreport 10:849-54. 1999
    A homozygous CGRP-/- mouse line was generated by the targeted disruption of exon 5 in the calcitonin/alphaCGRP gene using homologous recombination. The mutant mice lack alphaCGRP mRNA...
  13. ncbi Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium
    T Ito
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Development 127:3913-21. 2000
    ..Thus, the neuroendocrine differentiation depends on basic helix-loop-helix factors, and Notch/Notch-ligand pathways may be involved in determining the cell differentiation fate in fetal airway epithelium...
  14. ncbi Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity
    L Zhang
    Department of Anatomy and Neurosciences, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Pain 89:265-73. 2001
    ..released from nerve terminals, including amino acids, substance P (SP) and calcitonin gene-related peptide (CGRP)...
  15. ncbi A TRP channel that senses cold stimuli and menthol
    Andrea M Peier
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Cell 108:705-15. 2002
    ..Our identification of a cold-sensing TRP channel in a distinct subpopulation of sensory neurons implicates an expanded role for this family of ion channels in somatic sensory detection...
  16. pmc Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid
    Pin Xian Xu
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Development 129:3033-44. 2002
    ..5 in Eya1(-/-) embryos. Our results indicate that Eya1 controls critical early inductive events involved in the morphogenesis of thymus, parathyroid and thyroid...
  17. ncbi Effect of Brn-3a deficiency on parvalbumin-, calbindin D-28k-, calretinin- and calcitonin gene-related peptide-immunoreactive primary sensory neurons in the trigeminal ganglion
    H Ichikawa
    Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Neuroscience 113:537-46. 2002
    Immunohistochemistry for parvalbumin, calbindin D-28k, calretinin and calcitonin gene-related peptide (CGRP) was performed on the trigeminal ganglion and oro-facial tissues in Brn-3a wildtype and knockout mice at embryonic day 18...
  18. ncbi Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons
    Ken ichi Inoue
    Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 5:946-54. 2002
    ..Our data demonstrate that Runx3 is critical in regulating the axonal projections of a specific subpopulation of DRG neurons...
  19. ncbi Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide
    Thorsten Schinke
    Department of Trauma, Hand, and Reconstructive Surgery, Hamburg University School of Medicine, Martinistrasse 52, Hamburg 20246, Germany
    J Bone Miner Res 19:2049-56. 2004
    We recently described an unexpected high bone mass phenotype in mice lacking the Calca gene that encodes CT and alphaCGRP...
  20. pmc A developmental switch in the response of DRG neurons to ETS transcription factor signaling
    Simon Hippenmeyer
    Biozentrum, Department of Cell Biology, University of Basel, Switzerland
    PLoS Biol 3:e159. 2005
    ..Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation...
  21. ncbi The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation
    Henrik Fagman
    Institute of Anatomy and Cell Biology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Dev Dyn 235:444-55. 2006
    ..It is suggested that thyroid inductive signals arise from embryonic vessels, and that this provides ideas to conceptually new pathogenetic mechanisms of thyroid dysgenesis...
  22. pmc Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid
    Takashi Kusakabe
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Dyn 235:1300-9. 2006
    ..1 expression. These results demonstrate that T/ebp/Nkx2.1 plays a role in the survival of UBB cells, their dissemination into the thyroid diverticulum, and the formation of UBB-derived vesicular structure...
  23. ncbi Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain
    Chih Li Chen
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Neuron 49:365-77. 2006
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy...
  24. ncbi A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification
    Ina Kramer
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Neuron 49:379-93. 2006
    ..contrast, Runx1 controls neuronal diversification within Ngn1-dependent TrkA+ neurons by repression of neuropeptide CGRP expression and controlling the fine pattern of laminar termination in the dorsal spinal cord...
  25. ncbi Mash1 regulates the development of C cells in mouse thyroid glands
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Dev Dyn 236:262-70. 2007
    ..The C cells of newborn mice are immunoreactive for calcitonin, calcitonin gene-related peptide (CGRP), protein gene product (PGP) 9...
  26. ncbi Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo
    Jian Zhong
    Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7250, USA
    Nat Neurosci 10:598-607. 2007
    ..We conclude that Raf function is crucial for several aspects of DRG neuron development, including differentiation and axon growth...
  27. ncbi A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons
    Wenqin Luo
    The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 54:739-54. 2007
    ..These findings support a model in which NGF controls maturation of nonpeptidergic DRG neurons through a combination of GFR/Ret-dependent and -independent signaling pathways...
  28. ncbi Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER
    Marit D Harzenetter
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, Munich, Germany
    J Immunol 179:607-15. 2007
    ..the nervous and immune systems involves the release of neuropeptides, such as calcitonin gene-related peptide (CGRP), from sensory nerves during inflammation...
  29. ncbi Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine development
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    J Histochem Cytochem 55:1075-88. 2007
    ..These results indicated that murine thyroid C cells are derived from the endodermal epithelial cells of the fourth pharyngeal pouch and do not originate from neural crest cells...
  30. ncbi Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential
    Jianghui Meng
    International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin 9, Ireland
    J Cell Sci 120:2864-74. 2007
    Calcitonin-gene-related peptide (CGRP), a potent vasodilator that mediates inflammatory pain, is elevated in migraine; nevertheless, little is known about its release from sensory neurons...
  31. pmc Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice
    Kazutake Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 104:16702-7. 2007
    Calcitonin gene-related peptide (CGRP) is thought to be a prominent neuropeptide in cardiovascular regulation and neuroimmune modulation...
  32. pmc The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord
    Hannes Schmidt
    Max Delbruck Centrum fur Molekulare Medizin, Berlin D 13092, Germany
    J Cell Biol 179:331-40. 2007
    ..Hence, our data demonstrate that Npr2 and cGKI are essential constituents of the signaling pathway underlying axonal bifurcation at the DREZ and neuronal connectivity in the dorsal spinal cord...
  33. doi Distinct chemical classes of medium-sized transient receptor potential channel vanilloid 1-immunoreactive dorsal root ganglion neurons innervate the adult mouse jejunum and colon
    L L Tan
    Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
    Neuroscience 156:334-43. 2008
    ..size and expression patterns of transient receptor potential vanilloid 1 (TRPV1), calcitonin gene-related peptide (CGRP), substance P (SP), neuronal nitric oxide synthase (NOS) and isolectin B4-binding (IB4) in dorsal root ganglion (..
  34. pmc Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide
    Masaya Toda
    Departments of Pharmacology and Anesthesiology, Kitasato University School of Medicine, Kanagawa 228 8555, Japan
    Proc Natl Acad Sci U S A 105:13550-5. 2008
    A neuropeptide, calcitonin gene-related peptide (CGRP), is widely distributed in neuronal systems and exhibits numerous biological activities...
  35. pmc Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice
    Hiroshi Hasegawa
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Comp Neurol 511:543-56. 2008
    ..Our results revealed the subtype identities of TrkC-positive mechanosensory neurons and demonstrated the usefulness of HS3ST-2 as a genetic marker for these subclasses of neurons...
  36. doi FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Dev Dyn 238:503-13. 2009
    ..Thus, the separation, migration, and survival of the pharyngeal organs were impaired in the FRS2alpha(2F/2F) mutants...
  37. pmc Notch signaling controls the balance of ciliated and secretory cell fates in developing airways
    Po Nien Tsao
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Development 136:2297-307. 2009
    ..It might also be relevant to mediate the metaplastic changes in the respiratory epithelium that occur in pathological conditions, such as asthma and chronic obstructive pulmonary disease...
  38. pmc Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis
    Keli Xu
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College St, East Tower, Rm 14 309, Toronto, Ontario, Canada M5G 1L7
    Am J Physiol Lung Cell Mol Physiol 298:L45-56. 2010
    ..In sum, these results demonstrate that Lfng functions to enhance Notch signaling in myofibroblast precursor cells and thereby to coordinate differentiation and mobilization of myofibroblasts required for alveolar septation...
  39. pmc Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate
    Mitsuru Morimoto
    Department of Developmental Biology and Division of Dermatology, Washington University School of Medicine, Box 8103, Saint Louis, MO 63110 1095, USA
    J Cell Sci 123:213-24. 2010
    ..These analyses suggest that the impact of gamma-secretase inhibitors on branching in vitro reflect a non-cell autonomous contribution from endothelial or vSMC-derived signals...
  40. pmc Signaling via Alk5 controls the ontogeny of lung Clara cells
    Yiming Xing
    Department of Pediatrics, Division of Neonatology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 137:825-33. 2010
    ..Thus, the signaling pathway by which TGFbeta/ALK5 regulates Clara cell differentiation may entail inhibition of Pten expression, which in turn activates ERK and AKT phosphorylation...
  41. doi Hepatocyte growth factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons
    Eduardo Gascon
    Institut de Biologie du Developpement de Marseille Luminy, Unite Mixte de Recherche 6216, Centre National de la Recherche Scientifique Université de la Méditerranée, 13288 Marseille, France
    J Neurosci 30:12414-23. 2010
    ..derived from the RUNX1 lineage, require Met activity for the proper extinction of Runx1 and optimal activation of CGRP (calcitonin gene-related peptide)...
  42. pmc An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates
    Ting Guo
    Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 14:31-6. 2011
    ..Thus, conserved growth factors control divergent neuronal transcriptional events that mediate interspecies differences in neural circuits and the behaviors that they control...
  43. pmc Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons
    Daniel J Cavanaugh
    Departments of Anatomy, University of California, San Francisco, California 94158, USA
    J Neurosci 31:10119-27. 2011
    ....
  44. pmc CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch
    Eric S McCoy
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e36355. 2012
    Calcitonin gene-related peptide (CGRPα, encoded by Calca) is a classic marker of nociceptive dorsal root ganglia (DRG) neurons. Despite years of research, it is unclear what stimuli these neurons detect in vitro or in vivo...
  45. pmc Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways
    Arjun Guha
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 109:12592-7. 2012
    ....
  46. doi Calcitonin gene-related peptide and cyclic adenosine 5'-monophosphate/protein kinase A pathway promote IL-9 production in Th9 differentiation process
    Norihisa Mikami
    Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565 0871, Japan
    J Immunol 190:4046-55. 2013
    ..investigated one of the physiological mediators derived from the nervous system, calcitonin gene-related peptide (CGRP), in asthma and Th9 cells because CGRP and activation of the cAMP/protein kinase A (PKA) pathway by CGRP are known ..
  47. pmc Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold
    Eric S McCoy
    Department of Cell Biology and Physiology, UNC Neuroscience Center, The University of North Carolina at Chapel Hill, CB 7545, Chapel Hill, NC 27599, USA
    Neuron 78:138-51. 2013
    Calcitonin gene-related peptide (CGRP) is a classic molecular marker of peptidergic primary somatosensory neurons. Despite years of research, it is unknown whether these neurons are required to sense pain or other sensory stimuli...
  48. pmc Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling
    M Xiang
    Department of Molecular Biology, Johns Hopkins University School Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 93:11950-5. 1996
    ....
  49. ncbi Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice
    A M Salmon
    CNRS URA 2182, Neurobiologie moleculaire, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Nat Neurosci 4:357-8. 2001
    The neuropeptide alpha CGRP (calcitonin gene-related peptide) is involved in the complex process of pain signaling, but the precise contribution of alpha CGRP remains unclear...
  50. ncbi Analysis of the cellular expression pattern of beta-CGRP in alpha-CGRP-deficient mice
    Burkhard Schütz
    Laboratory of Molecular Neurobiology, Clinic for Psychiatry, University Medical Center, 53127 Bonn, Germany
    J Comp Neurol 476:32-43. 2004
    ..b>CGRP immunoreactivity (IR) was detected in many small and some large neurons in the dorsal root ganglia, was found in ..
  51. pmc Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene
    Jeffrey S Mogil
    Department of Psychology and Centre for Research on Pain, McGill University, Montreal, QC, Canada H3A 1B1
    Proc Natl Acad Sci U S A 102:12938-43. 2005
    ..Linkage mapping supports the contention that the genetic variant determining variable heat pain sensitivity across mouse strains affects the expression of the Calca gene that codes for CGRPalpha.
  52. ncbi Many major CNS axon projections develop normally in the absence of semaphorin III
    S M Catalano
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, 94720 3200, USA
    Mol Cell Neurosci 11:173-82. 1998
    ..Our data lead us to suggest that if Sema III functions in part to guide the formation of major axonal projections, then it does so in combination with both other semaphorins and other families of guidance molecules...
  53. ncbi A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervation
    B T Fundin
    Laboratory of Molecular Neurobiology, MBB, Karolinska Institute, S171 77 Stockholm, Sweden
    Development 126:2597-610. 1999
    ....
  54. ncbi Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia
    Yoshihiro Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, 641 8509 Japan
    J Neurosci 24:1941-7. 2004
    ..Thus, OSM plays an essential role in the development of a subtype of nociceptive neurons in the DRGs...
  55. ncbi Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene
    Xiang Jun Chen
    Jack Miller Center for Peripheral Neuropathy and Department of Neurology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 27:14515-24. 2007
    ..Together, we provide in vivo evidence that distinct mutations in cytoplasmic dynein can either result in a pure sensory neuropathy or in a sensory neuropathy with motor neuron involvement...
  56. doi DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain
    Ming Shi
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Mol Cell Neurosci 39:529-38. 2008
    ..Thus, our findings demonstrate that DCC is a key regulator of tangential migration of LC neurons during the embryonic development...
  57. pmc C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons
    Hannes Schmidt
    Department of Developmental Neurobiology, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin, Germany
    Proc Natl Acad Sci U S A 106:16847-52. 2009
    ..Functionally, the bifurcation error in CNP mutant mice is maintained at mature stages and results in a reduced input on secondary neurons as detected by patch-clamp recordings...
  58. doi Cilostazol improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus
    Juan Zhao
    Departments of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Neuropharmacology 58:774-83. 2010
    ..Cilostazol increased the release of calcitonin gene-related peptide (CGRP) and levels of cAMP in dorsal root ganglion (DRG) neurons isolated from wild-type (WT) mice...
  59. doi Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesity
    Christopher S Walker
    School of Biological Sciences, University of Auckland, Private Bag 92 019, Auckland 1142, New Zealand
    Endocrinology 151:4257-69. 2010
    ..These findings define a new role for alphaCGRP as a mediator of energy metabolism and opens up therapeutic opportunities to target CGRP action in obesity.
  60. doi An ongoing role of α-calcitonin gene-related peptide as part of a protective network against hypertension, vascular hypertrophy, and oxidative stress
    Sarah Jane Smillie
    Cardiovascular Division, King s College London, Franklin Wilkins Building, London, SE1 9NH, United Kingdom
    Hypertension 63:1056-62. 2014
    Calcitonin gene-related peptide (αCGRP) is a vasodilator, but there is limited knowledge of its long-term cardiovascular protective influence...
  61. doi Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception
    Nora E Szabo
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Neurosci 35:5233-46. 2015
    ..Together, our results demonstrate an important role for the intersection of Lmx1b and Hoxb8::cre expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal pain processing. ..
  62. doi Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPα transgenic reporter mouse
    Timothy J Hibberd
    Discipline of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia and
    Am J Physiol Gastrointest Liver Physiol 310:G561-73. 2016
    ..A transgenic calcitonin gene-related peptide-α (CGRPα)-mCherry reporter mouse, which enabled rapid identification of soma neurochemistry and morphology following ..
  63. ncbi Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development
    L Erkman
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Nature 381:603-6. 1996
    ..Mutation of Brn-3.1 results in complete deafness, owing to a failure of hair cells to appear in the inner ear, with subsequent loss of cochlear and vestibular ganglia...
  64. pmc Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis
    Peng Li
    Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California Keck School of Medicine, 1425 San Pablo St, Los Angeles, CA 90033, USA
    Dev Biol 361:116-24. 2012
    ....
  65. pmc Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors
    Claudia Lopes
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 32:9706-15. 2012
    ..Collectively, these studies suggest that genetically Tlx3 acts in combination with Runx1 to control the development of a cohort of nociceptors, thermoceptors, and pruriceptors in mice...
  66. doi Enhancement of CGRP sensory afferent innervation in the gut during the development of food allergy in an experimental murine model
    Jaemin Lee
    Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    Biochem Biophys Res Commun 430:895-900. 2013
    ..Calcitonin gene-related peptide (CGRP) is exclusively contained in intrinsic and extrinsic primary afferent neurons in the mouse intestine...
  67. pmc Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development
    Yadi Huang
    Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    PLoS ONE 8:e57695. 2013
    ..Moreover, Hif3α affected the expression of genes not typically involved in the hypoxia response, providing evidence for a novel function of Hif3α beyond the hypoxia response...
  68. ncbi Peripherally administered calcitonin gene-related peptide decreases food intake in mice
    J E Morley
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, St Louis, MO 63106, USA
    Peptides 17:511-6. 1996
    Previously, calcitonin gene-related peptide (CGRP) decreased food intake when administered ICV but not when administered peripherally to rats...
  69. ncbi Dopamine neuron agenesis in Nurr1-deficient mice
    R H Zetterström
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Science 276:248-50. 1997
    ..These results suggest that putative Nurr1 ligands may be useful for treatment of Parkinson's disease and other disorders of midbrain dopamine circuitry...
  70. ncbi Localization of calcitonin gene-related peptide mRNA in developing olfactory axons
    S Denis-Donini
    Department of Biology, University of Milan, Via Celoria 26, I 20133 Milan, Italy
    Cell Tissue Res 294:81-91. 1998
    During development of the olfactory pathway, calcitonin gene-related peptide (CGRP) expression is regulated both temporally and spatially...
  71. ncbi Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development
    J T Lu
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Neurosci 14:99-120. 1999
    ..b>CGRP has been implicated in a variety of physiological processes including peripheral vasodilation, cardiac acceleration ..
  72. ncbi Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut
    H M Young
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia
    Dev Dyn 216:137-52. 1999
    ..Calcitonin gene-related peptide (CGRP) neurons showed Phox2b and Ret-immunoreactivity, but not Phox2a immunoreactivity...
  73. ncbi Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections
    H J Cheng
    Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143 0452, USA
    Neuron 32:249-63. 2001
    ..Analysis of plexin-A3 knockout mice shows that plexin-A3 contributes to Sema3F and Sema3A signaling and that plexin-A3 regulates the development of hippocampal axonal projections in vivo...
  74. ncbi Developmental timing of hair follicle and dorsal skin innervation in mice
    Eva M J Peters
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg D 20246, Germany
    J Comp Neurol 448:28-52. 2002
    ..This sequence of developing innervation consistently correlates with hair follicle development, indicating a close interdependence of neuronal and epithelial morphogenesis...
  75. pmc Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants
    Eleni Goshu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Mol Cell Biol 22:4147-57. 2002
    ..The temporal and spatial expression patterns of Sim2 in these skeletal elements suggest that Sim2 regulates their growth and/or integrity...
  76. ncbi Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons
    Pontus C Holm
    Department of Medical Biochemistry and Biophysics, Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm S 171 77, Sweden
    Development 130:3535-45. 2003
    ..In summary, our findings suggest that, unlike NT3 and GDNF, TrkB ligands are required and sufficient to promote the development of central noradrenergic neurons...
  77. ncbi Neuropeptides concentrations in the skin of a murine (NC/Nga mice) model of atopic dermatitis
    Masako Katsuno
    Department of Environmental Immuno Dermatology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa, Yokohama, Japan
    J Dermatol Sci 33:55-65. 2003
    ..It has been reported that the expression of neuropeptides (NPs), and the density and structure of peripheral nerves in atopic dermatitis (AD) are different from those in normal skin...
  78. ncbi Reduction of withdrawal signs after chronic nicotine exposure of alpha-calcitonin gene-related peptide knock-out mice
    Anne Marie Salmon
    CNRS UA D 1284 Récepteurs et Cognition, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Neurosci Lett 360:73-6. 2004
    ..We report that these animals develop a normal tolerance to the antinociceptive effects of nicotine, but display an attenuation of somatic withdrawal symptoms...
  79. ncbi Distribution of calcitonin gene-related peptide at the neuromuscular junction of mdx mice
    Maria Julia Marques
    Department of Anatomy, Institute of Biology, State University of Campinas, Campinas, Sao Paulo, Brazil
    Anat Rec A Discov Mol Cell Evol Biol 279:798-803. 2004
    ..One such factor is calcitonin gene-related peptide (CGRP), which has been implicated in AChR synthesis and function...
  80. ncbi Differential expression of calcitonin gene-related peptide (CGRP) and choline acetyltransferase (ChAT) in the axotomized motoneurons of normoxic and hypoxic rats
    Hung Ming Chang
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 1, Section 1, Jen Ai Road, Taipei 100, Taiwan
    J Chem Neuroanat 28:239-51. 2004
    ..to determine how nerve injury and hypoxic insult would affect the expression of calcitonin gene-related peptide (CGRP) and choline acetyltransferase (ChAT) in the hypoglossal nucleus (HN) and nucleus ambiguus (NA)...
  81. ncbi Calcitonin gene-related peptide protects against hypertension-induced heart and kidney damage
    Scott C Supowit
    Texas A and M University System Health Science Center, Temple, TX, USA
    Hypertension 45:109-14. 2005
    ..These data suggest that deletion of the alpha-calcitonin gene-related peptide gene makes the heart and kidneys more vulnerable to hypertension-induced end organ damage...
  82. ncbi Targeted overexpression of calcitonin in gonadotrophs of transgenic mice leads to chronic hypoprolactinemia
    Ren Yuan
    Department of Pharmaceutical Sciences, University of Louisiana School of Pharmacy, 700 University Avenue, Monroe, LA 71209, USA
    Mol Cell Endocrinol 229:193-203. 2005
    ....
  83. ncbi The location and phenotype of proliferating neural-crest-derived cells in the developing mouse gut
    H M Young
    Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia
    Cell Tissue Res 320:1-9. 2005
    ..5). Thus, for enteric neurons, exit from the cell cycle appears to occur after the expression of pan-neuronal proteins but prior to the expression of markers of terminally differentiated neurons...
  84. ncbi Brn-3a is required for the generation of proprioceptors in the mesencephalic trigeminal tract nucleus
    H Ichikawa
    Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 1053:203-6. 2005
    ..The present study suggests that Brn-3a is required for the development of proprioceptors but not motoneurons in the trigeminal nervous system...
  85. ncbi Phenotypes of neural-crest-derived cells in vagal and sacral pathways
    R B Anderson
    Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia
    Cell Tissue Res 323:11-25. 2006
    ....
  86. ncbi Increased progenitor proliferation and apoptotic cell death in the sensory lineage of mice overexpressing N-myc
    Miwako Kobayashi
    Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheelesv 1, 171 77 Stockholm, Sweden
    Cell Tissue Res 323:81-90. 2006
    ....
  87. ncbi Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord
    S A Villeda
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
    Neuroscience 139:1385-96. 2006
    ..As the nociceptors in control and reeler dorsal root ganglia are similar, our results indicate that Reelin signaling is an essential contributor to the normal development of central circuits that underlie nociceptive processing and pain...
  88. ncbi Prenatal development of transient receptor potential vanilloid 1-expressing primary sensory projections to sacral autonomic preganglionic neurons
    Kengo Funakoshi
    Department of Neuroanatomy, Yokohama City University School of Medicine, 3 9 Fukuura, Yokohama, Japan
    Neurosci Lett 407:230-3. 2006
    ..Thus, the functional circuit for pelvic spinal reflexes, such as micturition induced by urine influx, might develop in the prenatal stages in mice...
  89. ncbi Calcitonin deficiency in mice progressively results in high bone turnover
    Antje K Huebner
    Center for Biomechanics and Skeletal Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Bone Miner Res 21:1924-34. 2006
    ..Unexpectedly, Calca-deficient mice lacking CT and alpha-calcitonin gene-related peptide (alphaCGRP) were described to have a high bone ..
  90. ncbi Contribution of sensory neurons to sex difference in the development of stress-induced gastric mucosal injury in mice
    Nobuhiko Shimozawa
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan
    Gastroenterology 131:1826-34. 2006
    ..a critical role in reducing stress-induced gastric mucosal injury by releasing calcitonin gene-related peptide (CGRP) through an increase in gastric mucosal levels of prostacyclin (PGI(2))...
  91. ncbi The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning
    H Fagman
    Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy at Goteborg University, SE 40530, Goteborg, Sweden
    Hum Mol Genet 16:276-85. 2007
    ..Thyroid dysgenesis related to Tbx1 inactivation may explain an overrepresentation of hypothyroidism occurring in patients with the 22q11DS...
  92. pmc Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis
    Alice T Shaw
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston 02114, USA
    Genes Dev 21:694-707. 2007
    ..These findings indicate that in the lung, Sprouty-2 plays a critical role in the regulation of oncogenic K-ras, and implicate counter-regulatory mechanisms in the pathogenesis of Ras-based disease...
  93. pmc Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11
    Cheng Zhong Wang
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Mol Cell Neurosci 35:368-76. 2007
    ..Taken together, our results demonstrate an essential role for Drg11 in the development of the Me5...
  94. ncbi A transient unresponsive state of self-scratching behaviour is induced in mice by skin-scratching stimulation
    Junichi Yamaoka
    Department of Dermatology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo, Japan
    Exp Dermatol 16:737-45. 2007
    ..Pretreatment with a calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37) did not affect the following self-scratching behaviour...
  95. doi Deletion of the mouse alpha-calcitonin gene-related peptide gene increases the vulnerability of the heart to ischemia-reperfusion injury
    Ruiping Huang
    Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA
    Am J Physiol Heart Circ Physiol 294:H1291-7. 2008
    Calcitonin gene-related peptide (CGRP), a potent vasodilator released from capsaicin-sensitive C-fiber and Adelta-fiber sensory nerves, has been suggested to play a beneficial role in myocardial ischemia-reperfusion (I/R) injury...
  96. pmc Calcitonin gene-related peptide biases Langerhans cells toward Th2-type immunity
    Wanhong Ding
    Department of Dermatology, Weill Cornell Medical College, New York, NY 10021, USA
    J Immunol 181:6020-6. 2008
    ..LC are associated with nerves containing the neuropeptide calcitonin gene-related peptide (CGRP), and CGRP inhibits LC Ag-presentation in several models including presentation to a Th1 clone...
  97. pmc Calcitonin induces expression of the inducible cAMP early repressor in osteoclasts
    Maobin Yang
    Department of Medicine, MC 1850, University of Connecticut Health Center, 263 Farmington Avenue, Farmington 06030, CT, USA
    Endocrine 33:245-53. 2008
    ..Furthermore, calcitonin decreased calcitonin receptor mRNA expression in wildtype osteoclasts, but not in Crem knockout osteoclasts. These data suggest that calcitonin induction of ICER in osteoclasts might regulate osteoclast activity...
  98. pmc Calcitonin gene-related peptide (CGRP) triggers Ca2+ responses in cultured astrocytes and in Bergmann glial cells from cerebellar slices
    Stefano Morara
    C N R, Institute of Neuroscience, Via Privata Bianco 9, 20131 Milan, Italy
    Eur J Neurosci 28:2213-20. 2008
    The neuropeptide calcitonin gene-related peptide (CGRP) is transiently expressed in cerebellar climbing fibers during development while its receptor is mainly expressed in astrocytes, in particular Bergmann glial cells...
  99. doi Pre-symptomatic alterations in subcellular betaCGRP distribution in motor neurons precede astrogliosis in ALS mice
    Cornelia Ringer
    Department of Molecular Neurosciences, Institute of Anatomy and Cell Biology, Philipps University, Robert Koch Strabetae 8, Marburg D 35032, Germany
    Neurobiol Dis 35:286-95. 2009
    In our study we investigated the pathology-related expression patterns of the two calcitonin gene-related peptide (CGRP) isoforms in spinal cord motor neurons of SOD1(G93A) mice, an animal model of the human motor neuron disease, ..
  100. doi Low affinity NGF receptor (p75 neurotrophin receptor) inhibitory antibody reduces pain behavior and CGRP expression in DRG in the mouse sciatic nerve crush model
    Yu Fukui
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Orthop Res 28:279-83. 2010
    ..we examined suppression of pain behavior and expression of neuropeptides such as calcitonin gene-related peptide (CGRP) using a p75 NTR inhibitory antibody, in a mouse sciatic nerve crush model...
  101. doi Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling
    Steeve Bourane
    INSERM U 583, F34091 Montpellier, France
    Neuron 64:857-70. 2009
    ..Our results provide evidence that genetic interactions involving Ret and MafA progressively promote the differentiation and diversification of LTMs...

Research Grants6

  1. Gene Transfer to the Inner Ear
    Anne Luebke; Fiscal Year: 2003
    ..Information gained from these studies will aid development of theraupeutic strategies targeted at genes involved in deafness. ..
  2. MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORS
    Anne Luebke; Fiscal Year: 2009
    ..In this next project period, we will focus on the LOC efferent fibers that contain calcitonin gene-related peptide (CGRP)...
  3. Biochemical Modulation of Nociceptive Circuits
    MARK JOHN ZYLKA; Fiscal Year: 2010
    ..Finally, we will test the hypothesis that this phosphatase modulates neuropathic pain behaviors in wild-type and phosphatase knockout mice. ..
  4. PROGESTERONE RECEPTOR IN BREAST DEVELOPMENT AND CANCER
    John Lydon; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  5. Roles for HIC1 in neural development and tumor suppression
    DAVID NEIL WATKINS; Fiscal Year: 2010
    ..These findings are of direct relevance to many cancers, since deregulation of pathways known to be important in embryonic development can help us understand the basis of human malignancy. ..
  6. Gene expression networks for metabolic syndrome traits in mice
    Thomas A Drake; Fiscal Year: 2010
    ....