Genomes and Genes
Gene Symbol: Cacnb4
Description: calcium channel, voltage-dependent, beta 4 subunit
Alias: 3110038O15Rik, Cchb4, voltage-dependent L-type calcium channel subunit beta-4, CAB4, calcium channel voltage-dependent subunit beta 4
- Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cellsPrakash Subramanyam
Department of Physiology and Medical Physics, Division of Physiology, Medical University Innsbruck, Innsbruck, Austria
Channels (Austin) 3:343-55. 2009..The activity-dependent shuttling of beta(4b) into and out of the nucleus indicates a specific role of this beta subunit in neurons, in communicating the activity of calcium channels to the nucleus...
- Age-related relationship between mRNA expression of GABA(B) receptors and calcium channel beta4 subunits in cacnb4lh miceF Lin
Departments of Medicine Neurology and Neurobiology, Duke University and Veterans Administration Medical Centers, Durham, NC 27705, USA
Brain Res Mol Brain Res 71:131-5. 1999..In this study, we examined the relationship between Cacnb4 and GABA(B) receptor mRNA expression in brains from Cacnb4lh homozygotes and (+/+) controls...
- Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1George D Leikauf
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
Am J Respir Crit Care Med 183:1499-509. 2011..Because acute lung injury is a sporadic disease produced by heterogeneous precipitating factors, previous genetic analyses are mainly limited to candidate gene case-control studies...
- Neuroanatomical substrates for paroxysmal dyskinesia in lethargic miceRajiv Devanagondi
Department of Neurology, Meyer Room 6 181, 600 North Wolfe Street, Johns Hopkins Hospital, Baltimore, MD 21287, and University of Tennessee, Memphis 38163, USA
Neurobiol Dis 27:249-57. 2007..Surgical removal of the cerebellum worsened ataxia but eliminated paroxysmal dyskinesias. These studies support the hypothesis that abnormal cerebellar output contributes to paroxysmal dyskinesias...
- The light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1)Lihua Y Marmorstein
Department of Ophthalmology and Vision Science, University of Arizona, Tucson 85711, USA
J Gen Physiol 127:577-89. 2006..Furthermore, we suggest that the loss of vision associated with BMD is not caused by the same pathologic process as the diminished LP, but rather is caused by as yet unidentified effects of best-1 on other cellular processes...
- Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neuronsGerald J Obermair
Department of Physiology and Medical Physics, Innsbruck Medical University, Austria
J Biol Chem 285:5776-91. 2010....
- Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalamiS J Caddick
Department of Neurology, Medical College of Virginia, Richmond, Virginia 23298, USA
J Neurophysiol 81:2066-74. 1999Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami...
- Pharmacological profiles of generalized absence seizures in lethargic, stargazer and gamma-hydroxybutyrate-treated model miceM Aizawa
Department of Pharmacology, College of Pharmacy, Nihon University, Chiba, Japan
Neurosci Res 29:17-25. 1997..These results suggest that GABAB receptors play a significant role in the pathogenesis of generalized absence seizures in these models, although the mechanism involved in stargazer mice differ from that in the other two...
- Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouseD L Burgess
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 88:385-92. 1997..to determine that the ataxia and seizures in the lethargic (lh) mouse arise from mutation of the beta-subunit gene Cchb4 on mouse chromosome 2...
- Ataxic mouse mutants and molecular mechanisms of absence epilepsyC F Fletcher
MGL, ABL BRP, NCI Frederick Cancer Research and Development Center, Frederick, MD, USA
Hum Mol Genet 8:1907-12. 1999..Then, from the new wave of genetic and functional studies of these mutants we discuss their prospects for yielding insight into the molecular mechanisms of epilepsy...
- Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layerSherry L Ball
Research Service, Cleveland VA Medical Center, Cleveland, Ohio, USA
Invest Ophthalmol Vis Sci 43:1595-603. 2002..The purpose of this study was to dentify which of the four beta subunits of VDCCs participates in the formation of this channel at the photoreceptor synapse and to determine how its absence affects visual processing...
- beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brainD L Burgess
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Neurosci 13:293-311. 1999..The existence of beta subunit reshuffling demonstrates that molecular plasticity of Ca2+ channel assembly, a normal feature of early brain development, is retained in the mature brain...
- ELKS1 and Ca(2+) channel subunit β4 interact and colocalize at cerebellar synapsesSara E Billings
Department of Anatomy and Cell Biology, University of Kansas Medical School, Kansas City, Kansas 66160, USA
Neuroreport 23:49-54. 2012..These results demonstrate that these two proteins interact in vitro and colocalize in the cerebellum, and suggest that their interaction may play a role at the molecular layer synapses of the cerebellum...
- Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expressionSolmaz Etemad
Department of Physiology and Medical Physics, Medical University Innsbruck, 6020 Innsbruck, Austria Center of Physiology and Pharmacology, Department of Neurophysiology and Pharmacology, Medical University Vienna, 1090 Vienna, Austria Division of Molecular Pathophysiology, Biocenter Division of Molecular Biology Biocenter Medical University Innsbruck, 6020 Innsbruck, Austria and Experimental and Clinical Pharmacology and Toxicology, University of Saarland, 66421 Homburg, Germany
J Neurosci 34:1446-61. 2014....
- BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosisPascal Beguin
Epithelial Cell Biology Laboratory and 2 Monoclonal Antibody Unit, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673
J Cell Biol 205:233-49. 2014..Thus, BARP can modulate the localization of Cavβ and its association with the Cavα1 subunit to negatively regulate VGCC activity...
- Modified autonomic regulation in mice mutated in the β4 subunit of the lh/lh calcium channelManabu Murakami
Department of Pharmacology, Hirosaki University, Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan Electronic address
Biochem Biophys Res Commun 461:200-5. 2015..Thus, our present study revealed that the β4 subunit played a significant role in regulation of sympathetic and parasympathetic nerve activities. ..
- Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brainClotilde Ferrándiz-Huertas
Dept Ciencias Médicas, Instituto de Investigación en Discapacidades Neurológicas IDINE, Facultad de Medicina, Universidad Castilla La Mancha, Albacete, Spain
J Neurochem 122:1095-107. 2012..These results shed new light on the developmental regulation and subcellular localization of Ca(v) β subunits, and their possible role in pre- and post-synaptic transmission...
- Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsyAbir Tadmouri
Unité INSERM U, Grenoble Institute of Neuroscience, Universite Joseph Fourier, La Tronche, France
EMBO J 31:3730-44. 2012..Here, we describe a novel signalling pathway in which the VGCC Cacnb4 subunit directly couples neuronal excitability to transcription...
- Single gene defects in mice: the role of voltage-dependent calcium channels in absence modelsD L Burgess
Department of Neurology, Baylor College of Medicine, Houston, TX 77303, USA
Epilepsy Res 36:111-22. 1999..tg) locus encodes the calcium channel alpha1 subunit gene Cacna1a, lethargic (lh) encodes the beta subunit gene Cacnb4, and stargazer (stg) encodes the gamma subunit gene Cacng2...
- Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neuronsYi Zhang
Developmental Neurogenetics Laboratory, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 22:6362-71. 2002..These alterations increase the probability for abnormal thalamocortical synchronization and absence epilepsy in tg, lh, and stg mice...
- Identification of epilepsy genes in human and mouseM H Meisler
Department of Human Genetics, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109 0618, USA
Annu Rev Genet 35:567-88. 2001..The development of pharmaceuticals directed towards specific epilepsy genotypes can be anticipated, and the introduction of patient mutations into the mouse genome will provide models for testing these targeted therapies...
- Paroxysmal dyskinesias in the lethargic mouse mutantZubair Khan
Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Neurosci 22:8193-200. 2002Lethargic mutant mice carry a mutation in the CCHB4 gene, which encodes the beta4 subunit of voltage-regulated calcium channels...
- Structures of the murine genes for the beta1- and beta4-subunits of the voltage-dependent calcium channelManabu Murakami
Department of Pharmacology, Akita University School of Medicine, 1 1 1, Hondou, Akita 010 8543, Japan
J Mol Neurosci 21:13-21. 2003..Furthermore, mRNA of these beta-subunits is strongly expressed in dorsal root ganglion neurons, which have many voltage-dependent calcium channels...
- Regional expression of L-type calcium channel subunits during cardiac developmentLourdes Acosta
Department of Experimental Biology, University of Jaen, Jaen, Spain
Dev Dyn 230:131-6. 2004..These findings suggest that beta subunits might play a major role in conferring calcium handling heterogeneity within the developing embryonic myocardium, while alpha1C subunits might contribute just transiently...
- Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant miceInseon Song
Center for Calcium and Learning, Korea Institute of Science and Technology, Cheongryang, Seoul, 136 791, Korea
J Neurosci 24:5249-57. 2004....
- Critical role for the beta regulatory subunits of Cav channels in T lymphocyte functionAbdallah Badou
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 103:15529-34. 2006..These observations suggest that the Cav channels expressed by T cells have adopted novel regulation/gating mechanisms...
- Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junctionSimon Kaja
Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
Brain Res 1143:92-101. 2007..1 channel function due to alpha(2)delta-2 absence. We conclude that alpha(2)delta-2, beta(4), and gamma(2) accessory subunits are redundant for the transmitter release-mediating function of presynaptic Ca(v)2.1 channels at the mouse NMJ...
- Gene expression in cortical interneuron precursors is prescient of their mature functionRenata Batista-Brito
Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Building, New York University Medical Center, 522 First Avenue, New York, NY 10016, USA
Cereb Cortex 18:2306-17. 2008..Moreover, our work has revealed that many of the genes expressed in cortical interneuron precursors have been independently linked to neurological disorders in both mice and humans...
- NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowthVsevolod Bodrikov
Zentrum für Molekulare Neurobiologie, Universitat Hamburg, 20246 Hamburg, Germany
J Cell Biol 182:1185-200. 2008..Thus, we reveal a novel function for a cell adhesion molecule in coordination of cell behavior with intracellular phosphatase activity...
- Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heartSabine Link
Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat des Saarlandes, 66421 Homburg, Germany
J Biol Chem 284:30129-37. 2009....
- Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4Stephanie Kuhn
Institute of Physiology II and Department of Otorhinolaryngology, Molecular Neurobiology, University of Tubingen, Tübingen Hearing Research Centre, Tubingen, Germany
Channels (Austin) 3:366-76. 2009..These results indicate that neither Ca(V)beta3 nor Ca(V)beta4 are indispensable for hair cell Ca(2+) currents but contribute to the overall current properties...
- Enhanced tonic GABAA inhibition in typical absence epilepsyDavid W Cope
School of Biosciences, Cardiff University, Cardiff, UK
Nat Med 15:1392-8. 2009..These results identify an apparently common cellular pathology in typical absence seizures that may have epileptogenic importance and highlight potential therapeutic targets for the treatment of absence epilepsy...
- Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neuronsB Schlick
Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck, Austria
Neuroscience 167:786-98. 2010..Developmental changes are likely determined by an intrinsic program and not regulated by changes in neuronal activity...
- The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 via a PXVXL binding motifXingfu Xu
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Biol Chem 286:9677-87. 2011..An NMR-based two-site docking model of β4c in complex with dimerized CSD is presented. Possible roles for the interaction are discussed...
- Mapping of the human Ca2+ channel beta 4 subunit to 2q22-23 and its expression in developing mouseR Betz
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Mamm Genome 9:310-1. 1998
- A study of the increased serum level of IgG1 in 'lethargic' mice combined with a depressed thymus-dependent lymphoid systemH C Dung
J Immunogenet 4:287-93. 1977..The authors note the similarities of other mouse mutations to that of the 'lethargic' mouse and propose the possibility that a common mechanism may account for immunologic deficiencies in several types of mutant mice...
- The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) miceD A Hosford
Department of Medicine, Duke University, Durham, NC
Science 257:398-401. 1992..Therefore, enhanced GABAB receptor-mediated synaptic responses may underlie absence seizures in lh/lh mice, and GABAB receptor antagonists hold promise as anticonvulsants for absence seizures...
- Glial contribution to seizure: carbonic anhydrase activity in epileptic mammalian brainD Guillaume
Laboratory of Biochemistry, University of Liege, Belgium
Epilepsia 32:10-5. 1991..The hypothesis of an adaptive glial mechanism, relating to the age-dependent decrease of seizure susceptibility in DBA/2 mice, is postulated...
- Histo-pathologic observations of the nervous and lymphoid tissues of "lethargic" mutant miceH C Dung
Tex Rep Biol Med 30:23-39. 1972
- Chronological studies of peripheral motor nerve conduction in "lethargic" miceJ M Herring
Electromyogr Clin Neurophysiol 21:121-34. 1981
- Neural network of structures in which GABAB receptors regulate absence seizures in the lethargic (lh/lh) mouse modelD A Hosford
Department of Medicine Neurology, Duke University, Durham, North Carolina, USA
J Neurosci 15:7367-76. 1995....
- Genetic mapping of the mouse genes encoding the voltage-sensitive calcium channel subunitsH Chin
Laboratory of Neurochemistry, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
Genomics 28:592-5. 1995..The alpha 1, beta 2, and beta 4 subunit genes, termed Cchna1, Cchb2, and Cchb4, are located at different sites on proximal Chr 2, while the beta 3 subunit gene Cchb3 maps to Chr 15 near Wnt1...
- Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole modelsD A Hosford
Department of Medicine Neurology, Duke University, Duke University Medical Center, Durham, North Carolina, USA
J Pharmacol Exp Ther 274:1399-403. 1995..These findings suggest that antiabsence activity may be a defining feature of GABAB receptor antagonists and provide a rationale for pursuing clinical trials of GABAB receptor antagonists in human patients with absence seizures...
- GABAB receptor-mediated effects in synaptosomes of lethargic (lh/lh) miceF H Lin
Department of Medicine Neurology, Duke University, Durham, North Carolina, USA
J Neurochem 65:2087-95. 1995..It is possible that selective effects of presynaptic GABAB receptors or GABA release in neocortex and thalamic nuclei of lh/lh mice may contribute to mechanisms underlying absence seizures...
- Increased number of GABAB receptors in the lethargic (lh/lh) mouse model of absence epilepsyF H Lin
Department of Medicine Neurology, Duke University, Durham, NC
Brain Res 608:101-6. 1993..Together with evidence that GABAB receptor activation can produce disinhibition, our data support a role for GABAB receptors in the expression of absence seizures in lh/lh mice...
- The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced productsR Berger
Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Isreal
Genome Res 6:361-70. 1996..These findings suggest that there may be more human transcripts than currently recognized. The possible involvement of the new growing family of Tmpo proteins in nuclear architecture and cell cycle control is discussed...
- Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouseC A Kozak
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4, Room 329, Bethesda, Maryland 20892 0460, USA
Mamm Genome 7:787-8. 1996
- The role of GABAB mechanisms in animal models of absence seizuresS J Caddick
Division of Neurology, Duke University Medical Center, Durham, NC, USA
Mol Neurobiol 13:23-32. 1996..The current evidence and interpretations of this work are presented here...
- Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 geneS O Castillo
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1766, USA
Genomics 41:250-7. 1997..These data help to explain the different response characteristics of two closely related early response genes, Nurr1 and Nur77...
- Gene mapping of SEZ group genes and determination of pentylenetetrazol susceptible quantitative trait loci in the mouse chromosomeS Wakana
Central Institute for Experimental Animals, Kawasaki, Japan
Brain Res 857:286-90. 2000..Since epilepsy is assumed to be a disease syndrome which is probably manifested by abnormal expression of multifocal genes, determination of the role of each chromosomal locus in the provocation of seizure activity is important...
- Ion channel mutations in mouse models of inherited neurological diseaseM H Meisler
Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
Ann Med 29:569-74. 1997..The mouse studies indicate that mutations in ion channel genes are likely to be responsible for a broad spectrum of clinical phenotypes in human neurological disorders...
- Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargicA Escayg
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, 48109 0618, USA
Genomics 50:14-22. 1998..in human neurological disease, we determined the chromosomal location and intron/exon structure of the human CACNB4 gene...
- Divergent expression of alpha1-protease inhibitor genes in mouse and humanJ Tardiff
Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Campus Box 347, Boulder, CO 80309, USA
Nucleic Acids Res 26:3794-9. 1998..This difference between the species appears to result from an absence of a functional macrophage-specific promoter in mice...
- Altered expression and assembly of N-type calcium channel alpha1B and beta subunits in epileptic lethargic (lh/lh) mouseM W McEnery
Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4970, USA
J Biol Chem 273:21435-8. 1998..It is intriguing to speculate that the increased excitability and susceptibility to seizures observed in the lh/lh mouse arises from the inappropriate expression of an immature population of N-type VDCC throughout neuronal development...
- Characterization of absence seizure-dependent cyclic AMP responsive element-and activator protein 1 DNA-binding activities in lethargic (lh/lh) miceK Ishige
Department of Pharmacology, College of Pharmacy, Nihon University, Funabashi, Japan
Neurosci Lett 262:53-6. 1999..These results suggest that enhanced nuclear CRE- and AP-1 DNA-binding activities in the thalamocortical region are related to generation and/or propagation of absence seizures in lethargic mice...
- Seizure disorders in mutant mice: relevance to human epilepsiesR S Puranam
Department of Medicine Neurology, Box 3676, Duke University Medical Center, 401 Bryan Research Building, Research Drive, Durham, North Carolina, 27710, USA
Curr Opin Neurobiol 9:281-7. 1999....
- Decreased (45)Ca(2)(+) uptake in P/Q-type calcium channels in homozygous lethargic (Cacnb4lh) mice is associated with increased beta3 and decreased beta4 calcium channel subunit mRNA expressionF Lin
Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27705, USA
Brain Res Mol Brain Res 71:1-10. 1999..Together, these findings indicate that a host of changes in VGCC subunit composition accompany reduced function of P/Q-type channels in homozygous lethargic mice...
- Glutamate decarboxylase isoforms in thalamic nuclei in lethargic mouse model of absence seizuresF H Lin
Departments of Medicine Neurology and Neurobiology, Epilepsy Research Laboratory, Duke University and Veterans Administration Medical Centers, Bldg 16, Rm 38, 508 Fulton St, Durham, NC, 27705, USA
Brain Res Mol Brain Res 71:127-30. 1999..These data suggest that GABA-synthesis is maintained or increased in NRT neurons in the Cacnb4lh mouse model...
- Mouse models of spike-wave epilepsyJ Barclay
Department of Paediatrics, The Rayne Institute, University College London Medical School, England, UK
Epilepsia 40:17-22. 1999..The question this raises as to the validity of these models for human spike-wave epilepsy is considered. Finally, the effect these discoveries will have on the understanding and treatment of human spike-wave epilepsy are discussed...
- Mutations of calcium channel beta subunit genes in miceD Freise
Institut fur Pharmakologie und Toxikologie, Universitat des Saarlandes, Homburg, Germany
Biol Chem 380:897-902. 1999..Here we summarize the phenotype of mice deficient in the beta1 subunit, the beta3 subunit or the beta4 subunit, respectively...
- Deficiency in the thymus-dependent immunity in "lethargic" mutant miceH C Dung
Transplantation 23:39-43. 1977..Implications of these results in understanding the immunological status of lethargic mice were considered...
- Presynaptic Ca(2+) influx at a mouse central synapse with Ca(2+) channel subunit mutationsJ Qian
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 20:163-70. 2000..The present study reveals compensatory molecular mechanisms in the regulation of presynaptic Ca(2+) entry and neurotransmitter release...
- Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functionsAbdallah Badou
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Science 307:117-21. 2005..Although Cav1 channels of lymphocytes retain their voltage dependency, T cell receptor stimulation dramatically increases channel opening, providing a new mechanism for calcium entry in lymphocytes...
- MURINE MODELS OF OCCUPATIONAL COPDGEORGE LEIKAUF; Fiscal Year: 2001..The well-characterized mouse model generated by this proposal will be useful in the further understanding of the relationship between occupational exposures, genetic markers, inflammatory responses, and COPD. ..
- GENETIC DETERMINATION OF ACUTE LUNG INJURYGEORGE LEIKAUF; Fiscal Year: 2004..Significance: This investigation seeks to uncover novel genes not previously associated with survival during acute lung injury. Such findings could provide new biological information and insights into this severe clinical condition. ..
- Genetic Determinants of Nickel-induced Lung InjuryGEORGE LEIKAUF; Fiscal Year: 2005..Determination of the relative roles of the genetic loci linked to nickel sulfate exposure is likely to improve our understanding of the mechanisms involved in acute lung injury. ..
- Growth Factor Protection in Acute Lung InjuryGEORGE LEIKAUF; Fiscal Year: 2009..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
- Characterization of N-type Ca channels in growth conesMaureen McEnery; Fiscal Year: 2005....
- Molecular Biology of Calcuim Channel Gamma SubunitsDaniel Burgess; Fiscal Year: 2006....