C1galt1

Summary

Gene Symbol: C1galt1
Description: core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
Alias: 2210410E06Rik, AV284120, T-synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, T-syn, core 1 O-glycan T-synthase, core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1, core 1 beta1,3-galactosyltransferase 1, core 1 beta3-Gal-T, core 1 beta3-Gal-T1, core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
Species: mouse

Top Publications

  1. pmc Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans
    Lijun Xia
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 N E 13th St, Oklahoma City, OK 73104, USA
    J Cell Biol 164:451-9. 2004
  2. ncbi Cloning and expression of human core 1 beta1,3-galactosyltransferase
    Tongzhong Ju
    W K Warren Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 277:178-86. 2002
  3. ncbi Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycans
    Suzannah A Williams
    Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    J Cell Sci 120:1341-9. 2007
  4. pmc Premature ovarian failure in mice with oocytes lacking core 1-derived O-glycans and complex N-glycans
    Suzannah A Williams
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Endocrinology 152:1057-66. 2011
  5. pmc Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 121:1657-66. 2011
  6. pmc Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2
    Kristina A Thomsson
    Department of Medical Biochemistry, University of Gothenburg, PO Box 440, 405 30 Gothenburg, Sweden
    Glycobiology 22:1128-39. 2012
  7. pmc Dysregulation of follicle development in a mouse model of premature ovarian insufficiency
    P Grasa
    Nuffield Department of Obstetrics and GynaecologyUniversity of Oxford, Women s Centre, Level 3, John Radcliffe Hospital, Oxford, UK
    Reproduction 152:591-601. 2016
  8. pmc O-glycans direct selectin ligands to lipid rafts on leukocytes
    Bojing Shao
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104
    Proc Natl Acad Sci U S A 112:8661-6. 2015
  9. pmc Molecular analysis of the cumulus matrix: insights from mice with O-glycan-deficient oocytes
    Panayiota Ploutarchou
    Nuffield Department of Obstetrics and GynaecologyWomen s Centre, Level 3, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UKFaculty of Life SciencesUniversity of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UKWellcome Trust Centre for Cell Matrix ResearchFaculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Reproduction 149:533-43. 2015
  10. doi Oocytes lacking O-glycans alter follicle development and increase fertility by increasing follicle FSH sensitivity, decreasing apoptosis, and modifying GDF9:BMP15 expression
    Patricia Grasa
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Women s Centre, John Radcliffe Hospital, Oxford, United Kingdom
    FASEB J 29:525-39. 2015

Research Grants

  1. REGULATION OF HEMATOPOIESIS BY THROMBOPOIETIN
    Warren Alexander; Fiscal Year: 2001
  2. Genomic dissection of platelet production
    Warren Alexander; Fiscal Year: 2009

Scientific Experts

  • Kristina A Thomsson
  • Lijun Xia
  • Warren Alexander
  • Suzannah A Williams
  • Jianxin Fu
  • Tadayuki Yago
  • J Michael McDaniel
  • Patricia Grasa
  • Rodger P McEver
  • Panayiota Ploutarchou
  • Bojing Shao
  • Jonathan J Miner
  • P Grasa
  • Padmaja Mehta-D'souza
  • Chiung Hui Liu
  • Felix Sommer
  • Yanfang Pan
  • Takashi Kudo
  • Ying Wang
  • William Rodgers
  • Hong Chen
  • Gunnar C Hansson
  • Malin E V Johansson
  • Frank Batista
  • Tongzhong Ju
  • Xiaowei Liu
  • Samuel McGee
  • Richard D Cummings
  • N Krzys
  • K Millar
  • S Sheikh
  • S Janjua
  • P Nawaggi
  • Paul R Crocker
  • Pedro Melo
  • Hendra Setiadi
  • Anthony J Day
  • Caroline M Milner
  • Min Chuan Huang
  • I Rue Lai
  • Hong Shiee Lai
  • Chia Hua Chen
  • Xiaofeng Cai
  • Miao Juei Huang
  • Fredrik Backhed
  • Christopher West
  • Yao Ming Wu
  • Nina Adam
  • Rey Heng Hu
  • Kesheng Dai
  • Changgeng Ruan
  • Brett Herzog
  • Satoru Takahashi
  • Kozue Hagiwara
  • Hisashi Narimatsu
  • Nobuhiro Ohkohchi
  • Takashi Yamaguchi
  • Michito Hamada
  • Yuzuru Ikehara
  • Yukinori Kozuma
  • Takashi Sato
  • Ken Matsumoto
  • Masatsugu Ema
  • Soichiro Murata
  • Heidy Kaune
  • Pamela Stanley
  • Linchao Lu
  • Zhenghui Liu
  • Jonathan Braun
  • Jerrold R Turner
  • Gurunadh R Chichili
  • Thomas J Sferra
  • Tao Wen
  • Emily Bradford
  • Lilah Mansour
  • Bo Wei
  • Arkadiusz G Klopocki
  • Maomeng Tong
  • Annelii Ny
  • Emma Nye
  • Holger Gerhardt
  • Maria I Ramirez
  • Lacramioara Ivanciu
  • Robert Silasi-Mansat
  • Florea Lupu
  • Peter Carmeliet
  • Karlien Hermans
  • Baoyun Xia
  • Kevin Brewer
  • William M Canfield

Detail Information

Publications22

  1. pmc Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans
    Lijun Xia
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 N E 13th St, Oklahoma City, OK 73104, USA
    J Cell Biol 164:451-9. 2004
    ..These data reveal an unexpected requirement for core 1-derived O-glycans during angiogenesis...
  2. ncbi Cloning and expression of human core 1 beta1,3-galactosyltransferase
    Tongzhong Ju
    W K Warren Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 277:178-86. 2002
    ..The core 1 beta3-Gal-T sequence has minimal homology with conserved sequences found in previously described beta3-galactosyltransferases, suggesting this enzyme is only distantly related to the known beta3-galactosyltransferase family...
  3. ncbi Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycans
    Suzannah A Williams
    Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    J Cell Sci 120:1341-9. 2007
    ..The combined data show that mouse ZP3 does not require terminal Gal or GlcNAc on either N- or O-glycans for fertilization...
  4. pmc Premature ovarian failure in mice with oocytes lacking core 1-derived O-glycans and complex N-glycans
    Suzannah A Williams
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Endocrinology 152:1057-66. 2011
    ..Females carrying floxed alleles of both the C1galt1 (T-syn) and Mgat1 glycosyltransferase genes and a ZP3Cre transgene, generate oocytes lacking complex O- and N-..
  5. pmc Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 121:1657-66. 2011
    ..These data suggest what we believe to be a new molecular mechanism for the pathogenesis of UC...
  6. pmc Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2
    Kristina A Thomsson
    Department of Medical Biochemistry, University of Gothenburg, PO Box 440, 405 30 Gothenburg, Sweden
    Glycobiology 22:1128-39. 2012
    ..mice, core 3 transferase knockout (C3Gnt(-/-)) mice and intestinal epithelial cell-specific core 1 knockout (IEC C1Galt1(-/-)) mice...
  7. pmc Dysregulation of follicle development in a mouse model of premature ovarian insufficiency
    P Grasa
    Nuffield Department of Obstetrics and GynaecologyUniversity of Oxford, Women s Centre, Level 3, John Radcliffe Hospital, Oxford, UK
    Reproduction 152:591-601. 2016
    ..mouse model of follicular POI, the Double Mutant (DM), arises from oocyte-specific deletion of Mgat1 and C1galt1 required for the generation of O- and N-glycans...
  8. pmc O-glycans direct selectin ligands to lipid rafts on leukocytes
    Bojing Shao
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104
    Proc Natl Acad Sci U S A 112:8661-6. 2015
    ..Here, we found that loss of core 1-derived O-glycans in murine C1galt1(-/-) neutrophils blocked raft targeting of PSGL-1, CD43, and CD44, but not of other glycosylated proteins, as ..
  9. pmc Molecular analysis of the cumulus matrix: insights from mice with O-glycan-deficient oocytes
    Panayiota Ploutarchou
    Nuffield Department of Obstetrics and GynaecologyWomen s Centre, Level 3, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UKFaculty of Life SciencesUniversity of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UKWellcome Trust Centre for Cell Matrix ResearchFaculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Reproduction 149:533-43. 2015
    ..In contrast to other in vivo models where modified expansion impairs fertility, the cumulus mass of C1galt1 Mutants, which have oocyte-specific deletion of core 1-derived O-glycans, is modified without impairing fertility...
  10. doi Oocytes lacking O-glycans alter follicle development and increase fertility by increasing follicle FSH sensitivity, decreasing apoptosis, and modifying GDF9:BMP15 expression
    Patricia Grasa
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Women s Centre, John Radcliffe Hospital, Oxford, United Kingdom
    FASEB J 29:525-39. 2015
    ..Here we analyze the basis of this phenotype using Mutant [core 1 β1,3-galactosyltransferase 1 (C1galt1)(FF):zona pellucida glycoprotein 3 Cre (ZP3Cre)] and Control (C1galt1(FF)) female mice...
  11. pmc Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets
    Yanfang Pan
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China
    Blood 124:3656-65. 2014
    ..These data indicate that sialylated O-glycans of PDPN are essential for platelet adhesion and prevent PDPN from proteolytic degradation primarily mediated by MMPs in the lymph. ..
  12. pmc C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin β1 glycosylation and activity
    Chiung Hui Liu
    Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan
    PLoS ONE 9:e94995. 2014
    ..We previously reported that core 1 β1,3-galactosyltransferase (C1GALT1) is frequently overexpressed in HCC tumors and its expression is associated with advanced tumor stage, metastasis,..
  13. pmc Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture
    Felix Sommer
    The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden Mucin Biology Group, Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 9:e85254. 2014
    ..Thus, the mucus layer plays a role in the regulation of gut microbiota composition, balancing intestinal inflammation, and affects gut architecture. ..
  14. doi C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes
    Takashi Kudo
    Department of Anatomy and Embryology, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan
    Blood 122:1649-57. 2013
    b>C1galt1 is essential for synthesis of the core 1 structure of mucin-type O-glycans...
  15. pmc Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation
    Patricia Grasa
    Nuffield Department of Obstetrics and Gynaecology, Women s Centre, Level 3, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Reproduction 144:455-65. 2012
    ..we investigate the basis of the small litter by evaluating ovulation rate and embryo development in DM (Mgat1(F/F)C1galt1(F/F):ZP3Cre) and Control (Mgat1(F/F)C1galt1(F/F)) females...
  16. pmc Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesis
    Frank Batista
    Department of Cell Biology, Albert Einstein College Medicine, New York, New York, USA
    Biol Reprod 86:179. 2012
    ..roles in spermatogenesis for major subclasses of N- and O-glycans and Notch signaling, male mice carrying floxed C1galt1, Pofut1, Notch1 or Mgat1 alleles and a testis-specific Cre recombinase transgene were generated...
  17. pmc Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulum
    Jonathan J Miner
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 286:9577-86. 2011
    ..Furthermore, the cytoplasmic domain provides a key signal to export precursors of PSGL-1 from the ER to the Golgi apparatus en route to the cell surface...
  18. pmc Core 1-derived O-glycans are essential E-selectin ligands on neutrophils
    Tadayuki Yago
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 107:9204-9. 2010
    ....
  19. pmc Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 118:3725-37. 2008
    ..the roles of EC O-glycans, we generated mice lacking T-synthase, a glycosyltransferase encoded by the gene C1galt1 that is critical for the biosynthesis of core 1-derived O-glycans, in ECs and hematopoietic cells (termed here ..
  20. pmc Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or Le(Y) in the preimplantation mouse embryo
    Suzannah A Williams
    Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Glycoconj J 26:335-47. 2009
    ..Furthermore, neither of these classes of glycan is essential for the expression of SSEA-1, SSEA-3, SSEA-4 or Le(Y) on mouse embryos...
  21. ncbi Targeted disruption of the gene encoding core 1 beta1-3-galactosyltransferase (T-synthase) causes embryonic lethality and defective angiogenesis in mice
    Lijun Xia
    Oklahoma Medical Research Foundation, Oklahoma City, USA
    Methods Enzymol 416:314-31. 2006
    ..These data reveal an unexpected requirement for core 1-derived O-glycans during angiogenesis...
  22. pmc Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
    Warren S Alexander
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:16442-7. 2006
    ..loss-of-function mutation in the gene encoding glycoprotein-N-acetylgalactosamine-3-beta-galactosyltransferase (C1GalT1), an enzyme essential for the synthesis of extended mucin-type O-glycans...

Research Grants2

  1. REGULATION OF HEMATOPOIESIS BY THROMBOPOIETIN
    Warren Alexander; Fiscal Year: 2001
    ..abstract_text> ..
  2. Genomic dissection of platelet production
    Warren Alexander; Fiscal Year: 2009
    ....