Bsn

Summary

Gene Symbol: Bsn
Description: bassoon
Alias: protein bassoon, presynaptic cytomatrix protein
Species: mouse

Top Publications

  1. pmc Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals
    S tom Dieck
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Cell Biol 142:499-509. 1998
  2. doi A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1
    Xiaolu Wang
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    J Neurosci 29:12584-96. 2009
  3. pmc Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
    Konark Mukherjee
    Department of Molecular and Cellular Physiology, Stanford University, CA 94304, USA
    Proc Natl Acad Sci U S A 107:6504-9. 2010
  4. pmc Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon
    Frederic Lanore
    Laboratoire Physiologie Cellulaire de la Synapse, CNRS UMR 5091, University of Bordeaux, Bordeaux, France
    J Physiol 588:2133-45. 2010
  5. pmc Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons
    Bradley N Buran
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 30:7587-97. 2010
  6. pmc Bassoon speeds vesicle reloading at a central excitatory synapse
    Stefan Hallermann
    Carl Ludwig Institute of Physiology, Medical Faculty, University of Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Neuron 68:710-23. 2010
  7. pmc Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling
    Thomas Frank
    InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Göttingen Medical Center, 37099 Gottingen, Germany
    Neuron 68:724-38. 2010
  8. doi Hippocampal enlargement in Bassoon-mutant mice is associated with enhanced neurogenesis, reduced apoptosis, and abnormal BDNF levels
    Alexandra Heyden
    Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Cell Tissue Res 346:11-26. 2011
  9. pmc Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex
    Susanne Tom Dieck
    Department of Neuroanatomy, Max Planck Institute for Brain Research, D 60528 Frankfurt Main, Germany
    J Cell Biol 168:825-36. 2005
  10. ncbi Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon
    Wilko D Altrock
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    Neuron 37:787-800. 2003

Scientific Experts

  • Alexandra Heyden
  • I Spiwoks-Becker
  • Bradley N Buran
  • Stacy L Donovan
  • Stefan Hallermann
  • Frank Angenstein
  • Eckart D Gundelfinger
  • Anna Fejtova
  • Susanne Tom Dieck
  • Wilko D Altrock
  • Tomoyuki Yoshida
  • Tobias Moser
  • Takeshi Uemura
  • Dana Specht
  • Sung Jin Lee
  • Masayoshi Mishina
  • Johann Helmut Brandstätter
  • Carolina Montenegro-Venegas
  • Nicola Strenzke
  • Thomas Frank
  • Jie Chen
  • Darina Khimich
  • Claudia Marini
  • Markus S Schröder
  • Zhizi Jing
  • Mark A Rutherford
  • Misato Yasumura
  • Veronica Ghiglieri
  • Hanna Regus-Leidig
  • Thomas Dresbach
  • Craig C Garner
  • Daniela Ivanova
  • Johann H Brandstätter
  • Emanuela Morelli
  • Rodrigo Herrera-Molina
  • Aaron B Wong
  • Martin Heine
  • Alejandro Mendoza Schulz
  • Daria Davydova
  • Carolin Wichmann
  • Stefano Romorini
  • Fuguo Wu
  • Corinna Wentzel
  • Clarissa L Waites
  • Lin Chien Huang
  • Sandra Dieni
  • Tina Pangrsic
  • Atsushi Iwakura
  • Hiroshi Nishimune
  • Barbara Picconi
  • Vincenza Bagetta
  • Masahiko Watanabe
  • Martine Ammassari-Teule
  • Yoichiro Iwakura
  • Paolo Calabresi
  • Jae Yeol Joo
  • Konark Mukherjee
  • Adish Dani
  • Frederic Lanore
  • Chieko Koike
  • Shizue Ohsawa
  • Toshiyuki Koyasu
  • Takahisa Furukawa
  • Mineo Kondo
  • Kazuo Funabiki
  • Xiaolu Wang
  • Shun Hamada
  • Akiko Tani
  • Ariadna Laguna
  • Shigeru Sato
  • Sonoko Hasegawa
  • Silke Haverkamp
  • Alexander Egner
  • Detlef Balschun
  • Karin Richter
  • Keith Vosseller
  • Constanze Burkhardt
  • Josef Ammermüller
  • Kerstin Reim
  • Eckart Dieter Gundelfinger
  • Christian Rosenmund
  • Shernaz X Bamji
  • Oliver Dick
  • Denny Schanze
  • Anika Dirks
  • Cornelia Schöne
  • Renato Frischknecht
  • Martin Zenker
  • Ferdinand Bischof
  • Abdeljalil Jellali

Detail Information

Publications57

  1. pmc Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals
    S tom Dieck
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Cell Biol 142:499-509. 1998
    ..These data indicate that Bassoon is a strong candidate to be involved in cytomatrix organization at the site of neurotransmitter release...
  2. doi A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1
    Xiaolu Wang
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    J Neurosci 29:12584-96. 2009
    ....
  3. pmc Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
    Konark Mukherjee
    Department of Molecular and Cellular Physiology, Stanford University, CA 94304, USA
    Proc Natl Acad Sci U S A 107:6504-9. 2010
    ..Thus, we propose that piccolo and bassoon play a redundant role in synaptic vesicle clustering in nerve terminals without directly participating in neurotransmitter release...
  4. pmc Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon
    Frederic Lanore
    Laboratoire Physiologie Cellulaire de la Synapse, CNRS UMR 5091, University of Bordeaux, Bordeaux, France
    J Physiol 588:2133-45. 2010
    ..altered during the first 2 weeks of postnatal development in mutant mice lacking the central region of Bassoon (Bsn(-/-) mice)...
  5. pmc Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons
    Bradley N Buran
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 30:7587-97. 2010
    ....
  6. pmc Bassoon speeds vesicle reloading at a central excitatory synapse
    Stefan Hallermann
    Carl Ludwig Institute of Physiology, Medical Faculty, University of Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Neuron 68:710-23. 2010
    ..Thus, our data show that the cytomatrix protein Bassoon speeds the reloading of vesicles to release sites at a central excitatory synapse.
  7. pmc Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling
    Thomas Frank
    InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Göttingen Medical Center, 37099 Gottingen, Germany
    Neuron 68:724-38. 2010
    ..structure and function of hair cell ribbon synapses following genetic disruption of the presynaptic scaffold protein Bassoon. Mutant synapses--mostly lacking the ribbon--showed a reduction in membrane-proximal vesicles, with ..
  8. doi Hippocampal enlargement in Bassoon-mutant mice is associated with enhanced neurogenesis, reduced apoptosis, and abnormal BDNF levels
    Alexandra Heyden
    Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Cell Tissue Res 346:11-26. 2011
    Mice mutant for the presynaptic protein Bassoon develop epileptic seizures and an altered pattern of neuronal activity that is accompanied by abnormal enlargement of several brain structures, with the strongest size increase in ..
  9. pmc Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex
    Susanne Tom Dieck
    Department of Neuroanatomy, Max Planck Institute for Brain Research, D 60528 Frankfurt Main, Germany
    J Cell Biol 168:825-36. 2005
    ..In mice deficient for the CAZ protein Bassoon, ribbons are not anchored to the presynaptic membrane but float freely in the cytoplasm...
  10. ncbi Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon
    Wilko D Altrock
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    Neuron 37:787-800. 2003
    Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion...
  11. ncbi The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina
    Oliver Dick
    Department of Neuroanatomy, Max Planck Institute for Brain Research, D 60528 Frankfurt Main, Germany
    Neuron 37:775-86. 2003
    ..We have investigated the role of the presynaptic cytomatrix protein Bassoon, a major component of the photoreceptor ribbon, in a mouse retina deficient of functional ..
  12. ncbi Hair cell synaptic ribbons are essential for synchronous auditory signalling
    Darina Khimich
    Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Goettingen, 37099 Goettingen, Germany
    Nature 434:889-94. 2005
    ..Here we show that anchoring of IHC ribbons is impaired in mouse mutants for the presynaptic scaffolding protein Bassoon. The lack of active-zone-anchored synaptic ribbons reduced the presynaptic readily releasable vesicle pool, ..
  13. ncbi Manganese-enhanced MRI reveals structural and functional changes in the cortex of Bassoon mutant mice
    Frank Angenstein
    Special Laboratory for Non Invasive Brain Imaging, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Cereb Cortex 17:28-36. 2007
    ..ME-MRI) was used to analyze the brain architecture in mice lacking the functional presynaptic active zone protein Bassoon. Anatomical characterization revealed a significant increase in the total brain volume in Bassoon mutants as ..
  14. pmc Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65
    Rodrigo Herrera-Molina
    From the Department of Neurochemistry and Molecular Biology
    J Biol Chem 289:8973-88. 2014
    ..These data demonstrate that Np65 is an important regulator of the number and function of synapses in the hippocampus. ..
  15. pmc Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse
    Alejandro Mendoza Schulz
    InnerEarLab, Department of Otolaryngology, University Medical Center Gottingen, Gottingen, Germany
    EMBO J 33:512-27. 2014
    ..Further, we conclude that bassoon promotes vesicular replenishment and, consequently, a large standing pool of readily releasable synaptic vesicles at the endbulb synapse. ..
  16. pmc Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis
    Aaron B Wong
    InnerEarLab Department of Otolaryngology, University Medical Center Gottingen, Gottingen, Germany
    EMBO J 33:247-64. 2014
    ..We conclude that IHC synapses undergo major developmental refinements, resulting in tighter spatial coupling between Ca(2)(+) influx and exocytosis. ..
  17. pmc Onecut1 is essential for horizontal cell genesis and retinal integrity
    Fuguo Wu
    Department of Ophthalmology Ross Eye Institute and Developmental Genomics Group, New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, New York 14203, USA
    J Neurosci 33:13053-65, 13065a. 2013
    ..In sum, these results demonstrate that Oc1 is a critical determinant of HC fate, and reveal that HCs are essential for photoreceptor viability, retinal integrity, and normal visual function. ..
  18. pmc mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking
    Corinna Wentzel
    Biozentrum, University of Basel, 4056 Basel, Switzerland
    Neuron 78:1012-23. 2013
    ..Thus, mSYD1A is a regulator of presynaptic release sites at central synapses. ..
  19. pmc Superresolution imaging of chemical synapses in the brain
    Adish Dani
    Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Neuron 68:843-56. 2010
    ..Combination with optogenetics further allowed molecular events associated with synaptic plasticity to be resolved at the single-synapse level...
  20. doi Bassoon specifically controls presynaptic P/Q-type Ca(2+) channels via RIM-binding protein
    Daria Davydova
    Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    Neuron 82:181-94. 2014
    ..1 and CaV2.2 to release sites is largely unknown. Here, we show that the presynaptic scaffolding protein Bassoon localizes specifically CaV2.1 to active zones via molecular interaction with the RIM-binding proteins (RBPs)...
  21. doi Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice
    Emanuela Morelli
    Fondazione Santa Lucia, IRCCS, Laboratory of Neurophysiology, Rome, Italy Istituto Serafico, Assisi, Perugia, Italy
    Exp Neurol 261:320-7. 2014
    ..enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures ..
  22. pmc Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo
    Daniela Ivanova
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany Research Group Presynaptic Plasticity, Leibniz Institute for Neurobiology, Magdeburg, Germany
    EMBO J 34:1056-77. 2015
    ..Our combined results reveal a mechanism for coupling activity-induced molecular rearrangements in the presynapse with reconfiguration of neuronal gene expression. ..
  23. ncbi Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif
    Constanze Burkhardt
    Abt Molekularbiologie, Institut fur Allgemeine Zoologie und Genetik, Westfalische Wilhelms Universitat, Schlossplatz 5, D 48149 Munster, Germany
    FEBS Lett 579:3821-8. 2005
    ..Sema4B co-localizes with PSD-95 at synaptic contacts between cultured hippocampal neurons. This synaptic localization depends on the presence of the PDZ-binding motif...
  24. pmc Regulation of presynaptic anchoring of the scaffold protein Bassoon by phosphorylation-dependent interaction with 14-3-3 adaptor proteins
    Markus S Schröder
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
    PLoS ONE 8:e58814. 2013
    ..This regulation mechanism might participate in molecular and structural presynaptic remodeling during synaptic plasticity...
  25. doi Evidence for synergistic and complementary roles of Bassoon and darkness in organizing the ribbon synapse
    I Spiwoks-Becker
    Institute of Microanatomy and Neurobiology, University Medical Center of the Johannes Gutenberg University, 55099 Mainz, Germany
    Neuroscience 236:149-59. 2013
    ..at the ribbon synapse has come from observations that, in photoreceptors lacking a full-size scaffolding protein Bassoon (Bsn(ΔEx4/5)), dissociation of SRs coincides with perturbed signal transfer...
  26. ncbi Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing
    Susanne Tom Dieck
    Department of Synaptic Plasticity, Max Planck Institute for Brain Research, D 60528 Frankfurt Main, Germany
    J Neurosci 32:12192-203. 2012
    ..However, rod synapses of CAST(-/-) mice, unlike in mouse mutants for the CAZ protein Bassoon, displayed anchored ribbons, normal vesicle densities, clustered Ca(2+) channels, and essentially normal ..
  27. doi GluRδ2 assembles four neurexins into trans-synaptic triad to trigger synapse formation
    Sung Jin Lee
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 32:4688-701. 2012
    ..Thus, the synaptogenic triad is assembled from tetrameric GluRδ2, hexameric Cbln1, and monomeric NRXN in the ratio of 1:2:4. These results suggest that GluRδ2 triggers synapse formation by clustering four NRXNs through triad formation...
  28. pmc BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons
    Sandra Dieni
    Department of Neuroanatomy, Institute of Anatomy and Cell Biology, Albert Ludwigs University Freiburg, 79104 Freiburg, Germany
    J Cell Biol 196:775-88. 2012
    ..They instead provide an ultrastructural basis for an anterograde mode of action of BDNF, contrasting with the long-established retrograde model derived from experiments with nerve growth factor in the peripheral nervous system...
  29. pmc TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade
    Chieko Koike
    Department of Developmental Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 107:332-7. 2010
    ..These results demonstrate that TRPM1-L is a component of the ON BC transduction channel downstream of mGluR6 in ON BCs...
  30. doi Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse
    Zhizi Jing
    Auditory Systems Physiology Group, InnerEarLab, University Medical Center, 37075 Gottingen, Germany
    J Neurosci 33:4456-67. 2013
    ..In the present study, we used genetic disruption of the presynaptic scaffold protein bassoon in mice to manipulate the morphology and function of the IHC synapse...
  31. pmc Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation
    Clarissa L Waites
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA
    EMBO J 32:954-69. 2013
    ..Our findings demonstrate a novel role for Bassoon and Piccolo as critical regulators of presynaptic ubiquitination and proteostasis...
  32. pmc Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea
    Lin Chien Huang
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neural Dev 7:38. 2012
    ..The OHC connections are then selectively eliminated, leaving sparse innervation by type II afferent fibres, whilst the type I afferent synapses with IHCs are consolidated...
  33. doi Lack of molecular-anatomical evidence for GABAergic influence on axon initial segment of cerebellar Purkinje cells by the pinceau formation
    Atsushi Iwakura
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 32:9438-48. 2012
    ..GAD), vesicular GABA transporter vesicular inhibitory amino acid transporter (VIAAT), cytomatrix active zone protein bassoon, GABA receptor GABA(A)Rα1, and cell adhesion molecule neuroligin-2...
  34. doi Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule
    Tomoyuki Yoshida
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Neurosci 32:2588-600. 2012
    ..isoforms in cultured cortical neurons suppressed synapse formation as indicated by decreases of active zone protein Bassoon puncta and dendritic protrusions...
  35. doi IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ
    Tomoyuki Yoshida
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 31:13485-99. 2011
    ..in cultured cortical neurons suppressed the accumulation of punctate staining signals for active zone protein Bassoon and decreased the number of dendritic protrusions...
  36. pmc Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity
    Shizue Ohsawa
    Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 107:13366-71. 2010
    ..Our findings suggest that Apaf-1/caspase-9-mediated nonapoptotic caspase signaling is required for the proper neural network formation during olfactory development...
  37. pmc Active zone density is conserved during synaptic growth but impaired in aged mice
    Jie Chen
    Department of Anatomy and Cell Biology and Kansas Intellectual and Developmental Disabilities Research Center, University of Kansas Medical School, Kansas City, Kansas 66160, USA
    J Comp Neurol 520:434-52. 2012
    ..zones in developing, mature, and aged mouse NMJs by immunohistochemical detection of the active zone-specific protein Bassoon. Bassoon is a cytosolic scaffolding protein essential for the active zone assembly in ribbon synapses and ..
  38. doi The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development
    Ariadna Laguna
    Center for Genomic Regulation, UPF, 08003 Barcelona, Spain
    Dev Cell 15:841-53. 2008
    ..Our data suggest a model in which dysregulation of the apoptotic response in differentiating neurons participates in the neuropathology of diseases that display DYRK1A gene-dosage imbalance effects, such as Down's syndrome...
  39. ncbi Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
    D A Persons
    Department of Experimental Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Genet 23:159-65. 1999
    ..We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia...
  40. pmc The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse
    M Kneussel
    Departments of Neurochemistry and Neuroanatomy, Max Planck Institute for Brain Research, Deutschordenstrasse 46, D 60528 Frankfurt Main, Germany
    Proc Natl Acad Sci U S A 97:8594-9. 2000
    ..Consistent with this idea, a close homolog of GABARAP, p16, has been found to function as a late-acting intra-Golgi transport factor...
  41. ncbi Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina
    Abdeljalil Jellali
    Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, INSERM EMI 99 18, Universite Louis Pasteur, 1 Place de l Hopital, 67091 Strasbourg Cedex, France
    J Comp Neurol 449:76-87. 2002
    ..VIAAT localization in mouse and human horizontal cells further support the role of inhibitory transmitters in lateral inhibition at the photoreceptor terminals...
  42. pmc Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
    Shernaz X Bamji
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:719-31. 2003
    ..This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion...
  43. pmc Structurally and functionally unique complexins at retinal ribbon synapses
    Kerstin Reim
    Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine, D 37075 Gottingen, Germany
    J Cell Biol 169:669-80. 2005
    ..The novel CPXs III and IV may contribute to the unique release efficacy of retinal sensory neurons...
  44. doi Epilepsy-induced abnormal striatal plasticity in Bassoon mutant mice
    Veronica Ghiglieri
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c o CERC, Rome, Italy
    Eur J Neurosci 29:1979-93. 2009
    ..As the absence of functional scaffolding protein Bassoon in mutant mice is associated with the development of pronounced spontaneous seizures, we utilized this new ..
  45. ncbi O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry
    Keith Vosseller
    Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, USA
    Mol Cell Proteomics 5:923-34. 2006
    ....
  46. pmc Compensation by tumor suppressor genes during retinal development in mice and humans
    Stacy L Donovan
    Department of Developmental Neurobiology, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    BMC Biol 4:14. 2006
    ..In this manuscript, we explore the different roles of the Rb family in human and mouse retinal development in order to better understand the species-specific difference in retinoblastoma susceptibility...
  47. ncbi Morphological and metabolic changes in the cortex of mice lacking the functional presynaptic active zone protein bassoon: a combined 1H-NMR spectroscopy and histochemical study
    Frank Angenstein
    Special Laboratory for Non Invasive Brain Imaging, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Cereb Cortex 18:890-7. 2008
    Mice lacking functional presynaptic active zone protein Bassoon are characterized by an enlarged cerebral cortex and an altered cortical activation pattern...
  48. doi Absence of functional active zone protein Bassoon affects assembly and transport of ribbon precursors during early steps of photoreceptor synaptogenesis
    Hanna Regus-Leidig
    Department of Biology, Animal Physiology, University of Erlangen Nuremberg, Staudtstr 5, 91058 Erlangen, Germany
    Eur J Cell Biol 89:468-75. 2010
    ..component of the precursor spheres and a key player in attaching the ribbon to the active zone is the presynaptic cytomatrix protein Bassoon...
  49. doi The amino-terminal domain of glutamate receptor delta2 triggers presynaptic differentiation
    Takeshi Uemura
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 377:1315-9. 2008
    ..These results suggest that GluRdelta2 triggers presynaptic differentiation by direct interaction with presynaptic components through the NTD...
  50. doi Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel colocalized with mGluR6 at mouse photoreceptor ribbon synapses
    Dana Specht
    Department of Biology, Animal Physiology, University of Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:505-15. 2009
    ..L-type VDCCalpha1 subtype expression in wild-type and mutant mice was examined, to investigate the underlying pathologic mechanism...
  51. doi Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation
    Shigeru Sato
    Department of Developmental Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka, 565 0874, Japan
    Nat Neurosci 11:923-31. 2008
    ..This may also advance our understanding of the molecular mechanisms underlying the retinal electrophysiological abnormalities observed in muscular dystrophy patients...
  52. doi The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse
    Sonoko Hasegawa
    KOKORO Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Mol Cell Neurosci 38:66-79. 2008
    ..Many M71 glomeruli, but apparently not MOR23 glomeruli, are heterogeneous in axonal innervation. Thus, Pcdha molecules are involved in coalescence of OSN axons into OR-specific glomeruli of the olfactory bulb...
  53. ncbi Type 4 OFF cone bipolar cells of the mouse retina express calsenilin and contact cones as well as rods
    Silke Haverkamp
    Department of Neuroanatomy, Max Planck Institute for Brain Research, 60528 Frankfurt Main, Germany
    J Comp Neurol 507:1087-101. 2008
    ..In contrast, true cone-selective type 1 and 2 OFF cone bipolar cells did not show sprouting in the Bassoon mouse mutant...
  54. pmc Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones
    Jie Chen
    Department of Anatomy and Cell Biology and Kansas Intellectual and Developmental Disabilities Research Center, University of Kansas Medical School, Kansas City, Kansas 66160, USA
    J Neurosci 31:512-25. 2011
    ..These results suggest that presynaptic VDCCs link the target-derived synapse organizer laminin β2 to active-zone proteins and function as scaffolding proteins to anchor active-zone proteins to the presynaptic membrane...
  55. doi Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons
    Jae Yeol Joo
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 406:627-32. 2011
    ..These results suggest that Cbln subtypes exert synaptogenic activities in cortical neurons by differentially interacting with NRXN variants containing S4...
  56. ncbi Structural and functional remodeling in the retina of a mouse with a photoreceptor synaptopathy: plasticity in the rod and degeneration in the cone system
    Dana Specht
    Department of Biology, Animal Physiology, University of Erlangen Nuremberg, Staudtstrasse 5, 91058 Erlangen, Germany
    Eur J Neurosci 26:2506-15. 2007
    ..In the retinae of mice, mutant for the presynaptic scaffolding protein Bassoon, signal transfer at photoreceptor ribbon synapses is disturbed due to impaired ribbon attachment to the ..