Bmp4

Summary

Gene Symbol: Bmp4
Description: bone morphogenetic protein 4
Alias: Bmp-4, Bmp2b, Bmp2b-1, Bmp2b1, bone morphogenetic protein 4, bone morphogenetic protein 2B
Species: mouse

Top Publications

  1. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
  2. ncbi Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
    Y Furuta
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 124:2203-12. 1997
  3. pmc Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    Amitabha Bandyopadhyay
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e216. 2006
  4. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
  5. ncbi Novel regulators of bone formation: molecular clones and activities
    J M Wozney
    Tissue Growth and Repair Program, Genetics Institute, Inc, Cambridge, MA 02140
    Science 242:1528-34. 1988
  6. ncbi Development of the mouse inner ear and origin of its sensory organs
    H Morsli
    National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
    J Neurosci 18:3327-35. 1998
  7. ncbi Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb
    Ying Liu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Development 129:5289-300. 2002
  8. ncbi Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development
    Jennifer Selever
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, TX 77030, USA
    Dev Biol 276:268-79. 2004
  9. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
  10. ncbi A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo
    T P Yamaguchi
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    Development 126:1211-23. 1999

Research Grants

  1. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2008
  2. A Critical Role of DMP-1 in Mineralization
    Jian Feng; Fiscal Year: 2007
  3. REGIONAL DIFFERENTIATION DURING FOREBRAIN DEVELOPMENT
    Anthony S LaMantia; Fiscal Year: 2010
  4. Hedgehog signaling links bladder injury and cancer
    DAVID MONTY BERMAN; Fiscal Year: 2010
  5. The function of Foxi3 in craniofacial development
    Takahiro Ohyama; Fiscal Year: 2008
  6. Commitment of Stem Cells to the Adipocyte Lineage
    ROBERT BOWERS; Fiscal Year: 2007
  7. Mechanically Responsive Regions of MEPE Gene
    JELICA HEINRICH; Fiscal Year: 2006
  8. Hedgehog Pathway in Urogenital Sinus Development
    David Berman; Fiscal Year: 2005
  9. HAND GENES IN CARDIAC DEVELOPMENT
    William Pu; Fiscal Year: 2004
  10. Regulation of Parietal Endoderm Migration
    Laura Grabel; Fiscal Year: 2006

Detail Information

Publications198 found, 100 shown here

  1. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
    ..These studies demonstrate that Shh regulates growth and determines the shape of the tooth. However, Shh signaling is not essential for differentiation of ameloblasts or odontoblasts...
  2. ncbi Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
    Y Furuta
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 124:2203-12. 1997
    ..by in situ hybridization the expression of five Bmp genes belonging to the Drosophila Decapentaplegic (Bmp2 and Bmp4) and 60A subgroups (Bmp5, Bmp6 and Bmp7)...
  3. pmc Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    Amitabha Bandyopadhyay
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e216. 2006
    Bone morphogenetic protein (BMP) family members, including BMP2, BMP4, and BMP7, are expressed throughout limb development. BMPs have been implicated in early limb patterning as well as in the process of skeletogenesis...
  4. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
    ..Our data demonstrate that beta-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm...
  5. ncbi Novel regulators of bone formation: molecular clones and activities
    J M Wozney
    Tissue Growth and Repair Program, Genetics Institute, Inc, Cambridge, MA 02140
    Science 242:1528-34. 1988
    ..Two of the encoded proteins (BMP-2A and BMP-3) are new members of the TGF-beta supergene family, while the third, BMP-1, appears to be a novel regulatory molecule...
  6. ncbi Development of the mouse inner ear and origin of its sensory organs
    H Morsli
    National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
    J Neurosci 18:3327-35. 1998
    ..Particular attention was focused on the developing utricle, saccule, and cochlea. Second, we used bone morphogenetic protein 4 (BMP4) and lunatic fringe (Fng) as molecular markers to identify the origin of the sensory structures...
  7. ncbi Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb
    Ying Liu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Development 129:5289-300. 2002
    ..Our data provide evidence that Gas1 acts to maintain high levels of FGF10 at the tip mesenchyme and support the proposal that Fgf10 expression in this region is crucial for maintaining Fgf8 expression in the AER...
  8. ncbi Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development
    Jennifer Selever
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, TX 77030, USA
    Dev Biol 276:268-79. 2004
    In the developing limb, Bmp4 is expressed in the apical ectodermal ridge (AER) and underlying mesoderm. Insight into the function of Bmp4 in limb development has been hampered by the early embryonic lethality of Bmp4 null embryos...
  9. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
    ..b>Bone morphogenetic protein 4 (Bmp4), a member of the Transforming growth factor family (TGF-beta), is conservatively expressed in ..
  10. ncbi A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo
    T P Yamaguchi
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    Development 126:1211-23. 1999
    ..The reduced number of proliferating cells in both the progress zone and the primitive streak mesoderm suggests that one function of Wnt5a is to regulate the proliferation of progenitor cells...
  11. pmc Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration
    Maksim V Plikus
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Nature 451:340-4. 2008
    ..Here we show that unexpected periodic expression of bone morphogenetic protein 2 (Bmp2) and Bmp4 in the dermis regulates this process...
  12. ncbi Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells
    Vesa Kaartinen
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Departments of Pathology and Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Development 131:3481-90. 2004
    ..Thus, the type I BMP receptor ALK2 plays an essential cell-autonomous role in the development of the cardiac outflow tract and aortic arch derivatives...
  13. pmc Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development
    Yan Geng
    Model Animal Research Center, Nanjing University, Nanjing 210061, China
    Proc Natl Acad Sci U S A 108:7058-63. 2011
    ..Mechanistically, Fstl1 interacted directly with BMP4, negatively regulated BMP4/Smad1/5/8 signaling, and inhibited BMP4-induced surfactant gene expression...
  14. ncbi Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4
    N R Dunn
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 188:235-47. 1997
    b>Bone morphogenetic protein 4 (Bmp4), a vertebrate homolog of Drosophila decapentaplegic (dpp), encodes a signaling protein with multiple functions during embryogenesis...
  15. ncbi Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos
    P Minoo
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
    Dev Biol 209:60-71. 1999
    ..These results demonstrate a critical role for Nkx2.1 in morphogenesis of the anterior foregut and the lung as well as in differentiation of pulmonary epithelial cells...
  16. ncbi Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway
    E S Monuki
    Division of Neurogenetics, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neuron 32:591-604. 2001
    ..Bimodal Lhx2 regulation can be recapitulated in explants using two roof plate-derived signaling molecules, Bmp4 and Bmp2...
  17. ncbi Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment
    William A Gomes
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 255:164-77. 2003
    ..determine whether BMPs regulate the astrocytic lineage in vivo, transgenic mice were constructed that overexpress BMP4 under control of the neuron-specific enolase (NSE) promoter...
  18. pmc Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4489-94. 2004
    The Bmp4 signaling molecule is expressed in ventral splanchnic and branchial-arch mesoderm and outflow-tract (OFT) myocardium, suggesting a role for Bmp4 in OFT development...
  19. doi Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage
    Jinhyung Park
    Department of Surgery, Hospital for Sick Children, Toronto, Canada
    Dev Dyn 239:514-26. 2010
    ..Both exogenous Bmp4 and Noggin rescue cartilage phenotype in Shh(-/-) tracheal culture, while promoting excessive cartilage development ..
  20. pmc Betaglycan is required for the establishment of nephron endowment in the mouse
    Kenneth A Walker
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e18723. 2011
    ..5-e14.5 kidneys demonstrated that heterozygous kidneys exhibited a transient decrease in Bmp4 expression at e11...
  21. doi Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling
    Kelly Lenton
    Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Stanford University, Stanford, California 94028, USA
    Genesis 49:784-96. 2011
    ..In conjunction with the newly recognized roles of Hedgehog deregulation in craniosynostosis, our study defines Ihh as an important positive regulator of cranial bone ossification...
  22. pmc Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development
    Chen Wang
    Department of Urology, Children s Hospital Boston, 300 Longwood Avenue, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 360:186-94. 2011
    ..Thus, Six1 and Eya1 are key regulators of both upper and lower urinary tract morphogenesis. Results from this study uncover essential roles of the PCM progenitors during genitourinary tract formation...
  23. pmc Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development
    Margarita Bonilla-Claudio
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 139:709-19. 2012
    We performed an in depth analysis of Bmp4, a critical regulator of development, disease, and evolution, in cranial neural crest (CNC)...
  24. pmc Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure
    B Chang
    The Howard Hughes Medical Institute, USA
    BMC Genet 2:18. 2001
    ..Bone morphogenetic proteins (BMPs) participate in various developmental processes. We tested the importance of Bmp4 gene dosage for ocular development and developmental glaucoma.
  25. ncbi Threshold-specific requirements for Bmp4 in mandibular development
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, 77030, USA
    Dev Biol 283:282-93. 2005
    ..b>Bmp4 is expressed in both distal, mandibular arch ectoderm and pharyngeal endoderm...
  26. ncbi Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH
    Julian Morcillo
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 133:3179-90. 2006
    ..Collectively, these data indicate that BMP7 is required for retinal fissure formation and that its activity is needed, before SHH signalling, for the generation of PAX2-positive cells at the optic disc...
  27. ncbi Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    G Winnier
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee 37232 2175, USA
    Genes Dev 9:2105-16. 1995
    ..Moreover, in the presumed absence of zygotic ligand, it appears that homozygous mutants can be rescued partially by related proteins or by maternal BMP-4...
  28. ncbi Morphogenesis
    B L Hogan
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Cell 96:225-33. 1999
  29. ncbi Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development
    X Sun
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California, USA
    Nat Genet 25:83-6. 2000
    ....
  30. ncbi Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte
    S V Outram
    Department of Biology, Imperial College of Science, Technology, and Medicine, London, United Kingdom
    Immunity 13:187-97. 2000
    ..We show that one consequence of pre-TCR signaling is downregulation of Smo, allowing DN thymocytes to proliferate and differentiate...
  31. ncbi beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13092, Berlin, Germany
    Cell 105:533-45. 2001
    ..Further analysis demonstrates that beta-catenin is essential for fate decisions of skin stem cells: in the absence of beta-catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate...
  32. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
  33. pmc Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development
    Jianquan Chen
    Department of Biology, University of Rochester, Rochester, New York 14642, USA
    Dev Biol 334:174-85. 2009
    ..Together, these results indicate that activation of the mesenchymal odontogenic program during early tooth development requires concerted actions of Bmp, Fgf and Wnt signaling from the presumptive dental epithelium to the mesenchyme...
  34. pmc Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord
    Yuko Muroyama
    Kondoh Differentiation Signaling Project, Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Corporation JST, Kinki Invention Center, Sakyo ku, Kyoto 606 8305, Japan
    Genes Dev 16:548-53. 2002
    ..Thus, Wnt signaling plays a critical role in the specification of cell types for dorsal interneurons...
  35. ncbi The mouse bone morphogenetic protein-4 gene. Analysis of promoter utilization in fetal rat calvarial osteoblasts and regulation by COUP-TFI orphan receptor
    J Q Feng
    Department of Medicine Endocrinology and Metabolism, University of Texas Health Science Center, San Antonio 78284, USA
    J Biol Chem 270:28364-73. 1995
    ..This suggests that COUP-TFI could act as a silencer for BMP-4 transcription in vivo...
  36. ncbi Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ
    X Zhao
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Mech Dev 99:29-38. 2000
    b>Bmp4 is a downstream gene of Msx1 in early mouse tooth development...
  37. ncbi Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Dev Cell 7:719-30. 2004
    ..Experiments on cultured tooth explants indicated that follistatin inhibits the ameloblast-inducing activity of BMP4 from the underlying mesenchymal odontoblasts and that follistatin expression is induced by activin from the ..
  38. ncbi Sonic hedgehog is required for cardiac outflow tract and neural crest cell development
    I Washington Smoak
    North Carolina State University, Raleigh, 27695, USA
    Dev Biol 283:357-72. 2005
    ..Our data suggest that SHH signaling does not act directly on NCCs as a survival factor, but rather acts to restrict the domains that NCCs can populate during early stages (e8.5-10.5) of cardiovascular and craniofacial development...
  39. pmc Ectodermal Wnt/β-catenin signaling shapes the mouse face
    Bethany S Reid
    Department of Craniofacial Biology and Cell and Developmental Biology, University of Colorado Denver, 12801 East 17th Avenue, PO Box 6511, Aurora, CO 80045, USA
    Dev Biol 349:261-9. 2011
    ....
  40. pmc BMP4 is essential for lens induction in the mouse embryo
    Y Furuta
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175 USA
    Genes Dev 12:3764-75. 1998
    ..Little is known, however, about the molecules mediating such inductive events. Here, we show that Bmp4, which is expressed strongly in the optic vesicle and weakly in the surrounding mesenchyme and surface ectoderm, ..
  41. ncbi Fgf10 is essential for limb and lung formation
    K Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Nat Genet 21:138-41. 1999
    ..Thus, we show here that Fgf10 serves as an essential regulator of lung and limb formation...
  42. pmc Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle
    H Kulessa
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    EMBO J 19:6664-74. 2000
    ..These results identify Bmps as key regulators of the genetic program controlling hair shaft differentiation in postnatal hair follicles...
  43. ncbi Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development
    Matthew M Goddeeris
    Departments of Cell Biology and Pediatrics, Neonatal Perinatal Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Development 134:1593-604. 2007
    ..Disruption of any of these steps can result in a single OFT phenotype...
  44. doi Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction
    Pauliina M Munne
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Development 136:393-402. 2009
    ..Considering the role of mesenchyme in tooth induction and the design of tissue engineering protocols, our work may have uncovered how delicate control of tissue quantities alone influences the outcome between induction and inhibition...
  45. pmc Differentiation of embryonic stem cells 1 (Dies1) is a component of bone morphogenetic protein 4 (BMP4) signaling pathway required for proper differentiation of mouse embryonic stem cells
    Luigi Aloia
    CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy
    J Biol Chem 285:7776-83. 2010
    ..Our results demonstrated that Dies1 is required for BMP4/Smad1 signaling cascade; in undifferentiated ESCs Dies1 knockdown did not affect the expression of leukemia ..
  46. doi Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade
    Yang Du
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Invest Ophthalmol Vis Sci 51:3764-73. 2010
    ..Retinal progenitor cells (RPCs) were used to study the effects of BMP4 on retinal cell differentiation and regulation of Id protein expression. RESULTS...
  47. pmc The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
    Yong Ri Jin
    Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 352:1-13. 2011
    ..Thus, our study identifies Rspo2 as a mesenchyme-derived factor that plays critical roles in regulating BA1 patterning and morphogenesis through ectodermal-mesenchymal interaction and a novel genetic factor for cleft palate...
  48. pmc Cyclic expression of lhx2 regulates hair formation
    Gunilla Törnqvist
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    PLoS Genet 6:e1000904. 2010
    ....
  49. ncbi Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
    M J Bitgood
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Dev Biol 172:126-38. 1995
    ..The frequent expression of Bmp-2, -4, and -6 in similar or adjacent cell populations suggests a conserved role for Hh/Bmp interactions in vertebrate development...
  50. ncbi Unique functions of Sonic hedgehog signaling during external genitalia development
    R Haraguchi
    Center for Animal Resources and Development CARD and Graduate School of Molecular and Genomic Pharmacy, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Development 128:4241-50. 2001
    ..by organ culture revealed that Shh could regulate mesenchymally expressed genes, patched 1 (Ptch1), bone morphogenetic protein 4 (Bmp4), Hoxd13 and fibroblast growth factor 10 (Fgf10), in the anlage: the genital tubercle (GT)...
  51. ncbi Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse
    Takeshi Fujiwara
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Ave South, Nashville, TN 37232 2175, USA
    Development 129:4685-96. 2002
    ..Using several different strategies, we provide evidence in the mouse that bone morphogenetic protein 4 (Bmp4) is required independently in two different sites for node morphogenesis and for LR patterning...
  52. ncbi Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development
    Yoichi Miyazaki
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
    Kidney Int 63:835-44. 2003
    We have suggested that bone morphogenetic protein 4 (BMP4), acting on the Wolffian duct and ureter epithelium, determines the budding site of the ureter by locally antagonizing ubiquitous inductive signal(s) from the metanephric ..
  53. pmc In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis
    Josée Aubin
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 18:1482-94. 2004
    ..In addition, formation of PGCs is impaired in Smad1(L/L) mutants, but restored by allelic complementation in Smad1(C/L) compound mutants. These results underscore the need to tightly balance BMP and MAPK signaling pathways through Smad1...
  54. ncbi Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin
    Reema Jasuja
    Program in Molecular and Cellular Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 279:51289-97. 2004
    ..These data and others regarding Chordin diffusion have implications for the paradigm of how Chordin is thought to regulate BMP signaling in the extracellular space and how gradients of BMP signaling are formed...
  55. doi Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb
    Yvan Lallemand
    CNRS URA, Institut Pasteur, Paris, France
    Dev Biol 331:189-98. 2009
    ....
  56. ncbi BMP4 substitutes for loss of BMP7 during kidney development
    Leif Oxburgh
    Wellcome Trust Center for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    Dev Biol 286:637-46. 2005
    ..b>BMP4-deficient embryos display mesodermal patterning defects at early post-implantation stages, whereas loss of BMP7 ..
  57. ncbi Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development
    D J Phippard
    Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK
    Development 122:2729-37. 1996
    ..The regulation of Msx-2 expression by oestrogen raises the possibility that hormonal regulation of mammary development is mediated through the control of epithelial-mesenchymal interactions...
  58. ncbi Heparan sulfate-FGF10 interactions during lung morphogenesis
    Konstantin I Izvolsky
    Pulmonary Center, Department of Medicine, Boston University School of Medcine, MA 02118, USA
    Dev Biol 258:185-200. 2003
    ..Our data suggest that the ability of FGF10 to induce local budding is critically influenced by developmentally regulated regional patterns of HS sulfation...
  59. doi Genetic modification of the inner ear lateral semicircular canal phenotype of the Bmp4 haplo-insufficient mouse
    Raf Vervoort
    Laboratory of Glycobiology and Developmental Genetics, Flanders Institute for Biotechnology VIB and Department of Human Genetics, Katholieke Universiteit Leuven, Herestraat 49 bus 602, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 394:780-5. 2010
    In the mouse, development of the lateral semicircular canal of the inner ear is sensitive to Bmp4 heterozygosity...
  60. ncbi SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis
    Karine Rizzoti
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:3437-48. 2007
    ..They also give insight into the formation of pharyngeal pouches, of which little is known in vertebrates. Finally, this work introduces two new players in craniofacial development - SOX3 and SOX2...
  61. ncbi Requirement for Wnt3 in vertebrate axis formation
    P Liu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 22:361-5. 1999
    ..These studies provide genetic proof for the requirement of Wnt3 in primary axis formation in the mouse...
  62. ncbi Generation of a loxP flanked bmp4loxP-lacZ allele marked by conditional lacZ expression
    Holger Kulessa
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genesis 32:66-8. 2002
  63. pmc Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation
    Mylah Villacorte
    Department of Organ Formation, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 391:1653-7. 2010
    ..Elucidation of the potential mechanisms underlying such D/ID development is an urgent medical issue to be solved. This work would be one of the first studies showing essential growth factor cascades in the D/ID formation...
  64. ncbi The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis
    S E Quaggin
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Development 126:5771-83. 1999
    ..Defects specific to later specialized cell types where Pod1 is expressed, such as the podocytes, were also observed, suggesting that this transcription factor may play multiple roles in kidney morphogenesis...
  65. pmc Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter
    Y Miyazaki
    Department of Pediatrics, Department of Pathology, Department of Cell Biology, and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 105:863-73. 2000
    In the normal mouse embryo, Bmp4 is expressed in mesenchymal cells surrounding the Wolffian duct (WD) and ureter stalk, whereas bone morphogenetic protein (BMP) type I receptor genes are transcribed either ubiquitously (Alk3) or ..
  66. pmc An essential role of Bmp4 in the atrioventricular septation of the mouse heart
    Kai Jiao
    Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 17:2362-7. 2003
    ..By combining use of a hypomorphic Bone morphogenetic protein 4 (Bmp4) allele with conditional gene inactivation, we here identify Bmp4 as a signal from the myocardium ..
  67. ncbi Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development
    Randy S Levinson
    Department of Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Development 132:529-39. 2005
    ..that comprises the normal renal capsule, the mutant capsule contains heterogeneous layers of cells, including Bmp4-expressing cells, which induce ectopic phospho-Smad1 signaling in nephron progenitors...
  68. ncbi The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot
    J Jernvall
    Institute of Biotechnology, University of Helsinki, Finland
    Development 125:161-9. 1998
    ..We show that p21 expression is induced by bone morphogenetic protein 4 (BMP-4) in isolated dental epithelia...
  69. ncbi Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice
    T Katagiri
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, USA
    Dev Genet 22:340-8. 1998
    ..absence of some Bmp genes expressed in the same areas, we have intercrossed heterozygous Bmp7 mice with Bmp2 +/-, Bmp4 +/-, or Bmp5 +/- animals. Bmp2/7 and Bmp5/7 double heterozygous animals do not present with any abnormalities...
  70. pmc Bmp4 is required for the generation of primordial germ cells in the mouse embryo
    K A Lawson
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, 3584 CT Utrecht, The Netherlands
    Genes Dev 13:424-36. 1999
    ..Here, we show that Bmp4 homozygous null embryos contain no PGCs...
  71. ncbi Teeth. Where and how to make them
    H Peters
    GSF Research Center for Environment and Health, Institute for Mammalian Genetics, Neuherberg, Germany
    Trends Genet 15:59-65. 1999
    ..This cascade provides a molecular model by which reciprocal tissue interactions are controlled...
  72. ncbi Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
    C Chiang
    Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Dev Biol 236:421-35. 2001
    ..According to this model, the limb bud signaling centers, including the zone of polarizing activity (ZPA) acting through Shh, are required to elaborate upon the axial information provided by the native limb field prepattern...
  73. ncbi The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway
    Giorgio R Merlo
    Dulbecco Telethon Institute DTI, Advanced Biotechnology Center, Largo R Benzi 10, 16132 Genoa, Italy
    Dev Biol 248:157-69. 2002
    ..1(Hmx3), Pax2, and Lfng have been seen, while expression of bone morphogenetic protein-4 (Bmp4) was drastically reduced...
  74. ncbi Malleal processus brevis is dispensable for normal hearing in mice
    Zunyi Zhang
    Division of Developmental Biology, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, USA
    Dev Dyn 227:69-77. 2003
    ..The expression of Bmp4, a known downstream target of Msx1 in several developing craniofacial organs, was down-regulated in the malleal ..
  75. pmc The role of Six1 in mammalian auditory system development
    Weiming Zheng
    McLaughlin Research Institute for Biomedical Sciences, 1520 23rd Street South, Great Falls, MT 59405, USA
    Development 130:3989-4000. 2003
    ..By contrast, Six1 is required for the activation of Fgf3 expression and the maintenance of Fgf10 and Bmp4 expression in the otic vesicle. Furthermore, loss of Six1 function alters the expression pattern of Nkx5...
  76. ncbi TBX1 is required for inner ear morphogenesis
    Francesca Vitelli
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 12:2041-8. 2003
    ..Our data suggest that Tbx1 deletion in del22q11 patients may cause not only external and middle ear defects but also sensorineural and vestibular phenotypes observed in these patients...
  77. ncbi Vertebrate crossveinless 2 is secreted and acts as an extracellular modulator of the BMP signaling cascade
    Mika Kamimura
    Institute of Development, Aging, and Cancer, Tohoku University, Aoba, Sendai, Miyagi, Japan
    Dev Dyn 230:434-45. 2004
    ..Our data show for the first time that CV-2 is a conserved, positive regulator of BMP signaling and that CR domain proteins act as both positive and negative modulators of BMP signaling...
  78. ncbi BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    Xi C He
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nat Genet 36:1117-21. 2004
    ..Thus, BMP signaling may control the duplication of intestinal stem cells, thereby preventing crypt fission and the subsequent increase in crypt number...
  79. ncbi Distinct functions for Bmp signaling in lip and palate fusion in mice
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:1453-61. 2005
    ..Moreover, conditional inactivation of the Bmp4 gene using the Nestin cre transgenic line resulted in isolated cleft lip...
  80. ncbi Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
    Weiguo Shu
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 283:226-39. 2005
    ..Wnt/beta-catenin functions upstream of BMP4, FGF signaling, and N-myc. Moreover, we show that beta-catenin and LEF/TCF activate the promoters of BMP4 and N-myc...
  81. ncbi Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract
    Yi Hui Chen
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center and Hospital, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Dev Biol 308:421-37. 2007
    ....
  82. ncbi Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis
    Jahan Ara
    Department of Pediatrics, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    J Neurosci Res 86:125-35. 2008
    ..Quantitative RT-PCR showed that expression of BMP4, BMP6, and BMP7 mRNA increased 2- to 4-fold in the lumbar spinal cords of animals with symptomatic EAE versus in ..
  83. pmc BMP4/Smad5 dependent stress erythropoiesis is required for the expansion of erythroid progenitors during fetal development
    Prashanth Porayette
    The Huck Institutes of the Life Sciences Molecular Medicine Option, The Pennsylvania State University, University Park, PA 16802, USA
    Dev Biol 317:24-35. 2008
    ..5, erythropoiesis predominates in the fetal liver. In this report we show that the BMP4/Smad5 dependent stress erythropoiesis pathway plays a key role in the expansion of erythroid progenitors in the ..
  84. pmc Extramedullary erythropoiesis in the adult liver requires BMP-4/Smad5-dependent signaling
    Laurie E Lenox
    The Department of Biochemistry, Molecular and Microbiology, Pennsylvania State University, University Park, Penn 16802 3500, USA
    Exp Hematol 37:549-58. 2009
    ..Given these observations, we propose to investigate whether the BMP-4-dependent stress erythropoiesis pathway can regulate extramedullary erythropoiesis in the livers of splenectomized mice...
  85. pmc Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns
    Julia Norden
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Circ Res 106:1212-20. 2010
    ..The systemic venous return myocardium (sinus node and sinus horns) forms only late in cardiogenesis from a pool of pericardial mesenchymal precursor cells...
  86. ncbi Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis
    S Bellusci
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
    Development 122:1693-702. 1996
    ..A model is proposed for the role of BMP4 and other signalling molecules in embryonic lung morphogenesis.
  87. ncbi Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos
    A T Dudley
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Dev Dyn 208:349-62. 1997
    ..The variable expressivity of the eye defect correlates with partially overlapping BMP4 and BMP7 expression domains during early eye induction...
  88. ncbi Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development
    M Weaver
    Howard Hughes Medical Institute, Department of Cell Biology, Nashville, TN, USA
    Development 126:4005-15. 1999
    ..One candidate is Bone Morphogenetic Protein 4 (Bmp4), which is expressed in a dynamic pattern in the epithelial cells in the tips of growing lung ..
  89. ncbi Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract
    T Kume
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 127:1387-95. 2000
    ..Here, we show that most compound heterozygotes have hypoplastic kidneys and a single hydroureter, while all heterozygotes are normal. This provides evidence that the two genes interact in kidney as well as heart development...
  90. ncbi Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation
    R Haraguchi
    Center for Animal Resources and Development CARD, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Development 127:2471-9. 2000
    ..plate epithelium of the genital tubercle (GT) together with other markers such as the Msx1, Fgf10, Hoxd13 and Bmp4 expressed in the mesenchyme...
  91. ncbi Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia development by concerted actions of BMP signaling [corrected]
    Kentaro Suzuki
    Center for Animal Resources and Development, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Development 130:6209-20. 2003
    ..Exogenously applied BMP4 downregulated the expression of Fgf8 and Wnt5a, concomitant with increased apoptosis and decreased cell ..
  92. ncbi Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development
    Lise Zakin
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Development 131:413-24. 2004
    ..We provide evidence that Tsg interacts genetically with Bmp4. When only one copy of Bmp4 is present, a requirement of Tsg for embryonic development is revealed...
  93. pmc The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup
    Hourinaz Behesti
    Developmental Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    BMC Dev Biol 6:62. 2006
    ..b>Bone morphogenetic protein 4 (Bmp4) is expressed in the dorsal optic vesicle as it transforms into the optic cup...
  94. ncbi BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling
    Sangeeta Pajni-Underwood
    Laboratory of Cancer and Developmental Biology National Institutes of Health, Frederick, MD 21702, USA
    Development 134:2359-68. 2007
    ..We conclude that during normal embryogenesis, BMP signaling to the AER indirectly regulates interdigit PCD by regulating AER-FGFs, which act as survival factors for the interdigit mesenchyme...
  95. pmc Role of fibroblast growth factor receptor 2 in kidney mesenchyme
    David Hains
    Center for Cell and Developmental Biology, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Pediatr Res 64:592-8. 2008
    ..Fgfr2 did not change expression domains of glial cell line-derived neurotrophic factor (GDNF), Robo2, bone morphogenetic protein 4, or Sprouty1, all of which regulate ureteric bud induction...
  96. pmc Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo
    Yumi Ueki
    Department of Biological Structure, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e38690. 2012
    ..Moreover, treatment of the retina with exogenous BMP4 along with NMDA damage led to a significant rescue of retinal ganglion cells...
  97. doi Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth
    Rushikesh Sheth
    Laboratory of Genetics and Development, Institut de recherches cliniques de Montreal IRCM, Quebec, Canada
    Development 140:2130-8. 2013
    ....
  98. ncbi Msx1 controls inductive signaling in mammalian tooth morphogenesis
    Y Chen
    Howard Hughes Medical Institute, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 122:3035-44. 1996
    ..Our results show that expression of Bone Morphogenetic Protein 4 (BMP4), the HMG box gene Lef1 and the heparan sulfate proteoglycan syndecan-1 is specifically reduced ..
  99. ncbi Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
    D Buscher
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Germany
    Mech Dev 62:175-82. 1997
    ..This data suggest that Gli3 is a regulator of Shh expression in mouse limb development...
  100. ncbi Murine cerberus homologue mCer-1: a candidate anterior patterning molecule
    C Biben
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Dev Biol 194:135-51. 1998
    ..Furthermore, both antagonised the ventrolateral mesoderm-inducing activity of coexpressed BMP4. In mouse embryos, mCer-1 was expressed at early gastrulation in a stripe of primitive endoderm along the future ..
  101. pmc Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
    R Jiang
    The Jackson Laboratory, Bar Harbor, Maine 04609 USA
    Genes Dev 12:1046-57. 1998
    ..These results demonstrate that Notch signaling mediated by Jag2 plays an essential role during limb, craniofacial, and thymic development in mice...

Research Grants19

  1. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2008
    ..Also, expression of Shh, Ptc, Fgfl0 and Bmp4 are all increased in Wnt5a(-/-) lungs...
  2. A Critical Role of DMP-1 in Mineralization
    Jian Feng; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  3. REGIONAL DIFFERENTIATION DURING FOREBRAIN DEVELOPMENT
    Anthony S LaMantia; Fiscal Year: 2010
    ....
  4. Hedgehog signaling links bladder injury and cancer
    DAVID MONTY BERMAN; Fiscal Year: 2010
    ..4) To test whether continuously enforced Hh signaling is sufficient to induce urothelial carcinogenesis. ..
  5. The function of Foxi3 in craniofacial development
    Takahiro Ohyama; Fiscal Year: 2008
    ..This project has significant potential for the future study of craniofacial and sensory organ development that will shed a light on the genetic mechanisms of craniofacial birth defects. ..
  6. Commitment of Stem Cells to the Adipocyte Lineage
    ROBERT BOWERS; Fiscal Year: 2007
    ..Further, the ability of the identified genes/proteins to induce adipocyte lineage commitment will be tested with both ex vivo and in vivo models. Targets for obesity therapies may be found. [unreadable] [unreadable]..
  7. Mechanically Responsive Regions of MEPE Gene
    JELICA HEINRICH; Fiscal Year: 2006
    ..This approach should enhance our understanding of the complex signaling pathways involved in bone response to mechanical loading. [unreadable] [unreadable]..
  8. Hedgehog Pathway in Urogenital Sinus Development
    David Berman; Fiscal Year: 2005
    ..The aim of the mentored training period is to acquire the necessary intellectual and technical skills to transition into independent investigation of urogenital development and its relationships to urologic disease. ..
  9. HAND GENES IN CARDIAC DEVELOPMENT
    William Pu; Fiscal Year: 2004
    ..This experience, and the information generated in this plan, will launch the applicant's career as an independent investigator. ..
  10. Regulation of Parietal Endoderm Migration
    Laura Grabel; Fiscal Year: 2006
    ..We will therefore examine PE outgrowth on Matrigel, plus and minus fibronectin, with a particular focus on examining the role of integrins in promoting directed versus random migration. [unreadable] [unreadable] [unreadable]..
  11. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  12. ROLES OF BMP4 & ITS REGULATION DURING TOOTH DEVELOPMENT
    Jian Feng; Fiscal Year: 2003
    ..b>Bone morphogenetic protein 4 (Bmp4), a crucial signal molecule in development of many tissues, is very likely required at early ..
  13. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  14. ROLES OF BMP4 AND ITS REGULATION IN TOOTH DEVELOPMENT
    Jian Feng; Fiscal Year: 2004
    ..The research plan will test the hypothesis that the Msx1-BMP4 signaling pathway is a key component in epithelial-mesenchymal interactions essential to tooth formation, and that ..
  15. Investigating the Role of Tbx1 in Ear Development
    Evan Braunstein; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  16. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  17. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. PATHOBIOCHEMISTRY OF PROTEOGLYCANS IN DEVELOPMENT
    Scott Saunders; Fiscal Year: 2009
    ..abstract_text> ..
  19. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....