Bloc1s4

Summary

Gene Symbol: Bloc1s4
Description: biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino
Alias: 2610101N07Rik, Blos4, Cno, biogenesis of lysosome-related organelles complex 1 subunit 4, BLOC-1 subunit 4, biogenesis of organelles complex-1, subunit 4, cappuccino, cappuccino, protein cappuccino homolog
Species: mouse

Top Publications

  1. ncbi Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex
    Babette Gwynn
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Blood 104:3181-9. 2004
  2. pmc Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus
    Karen Newell-Litwa
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 30:820-31. 2010
  3. ncbi Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1)
    Steven L Ciciotte
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 101:4402-7. 2003
  4. pmc The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth
    C A Ghiani
    Mental Retardation Research Center, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 7332, USA
    Mol Psychiatry 15:115, 204-15. 2010
  5. pmc The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse
    Jennifer Larimore
    Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 22:4854-67. 2011
  6. ncbi Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development
    Thuyen Nguyen
    Department of Dermatology, Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    J Invest Dermatol 119:1156-64. 2002
  7. ncbi Cappuccino mutation in an autoimmune-prone strain of mice suggests a role of platelet function in the progression of immune complex crescentic glomerulonephritis
    Minako Yoshida
    Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Arthritis Rheum 54:2934-43. 2006
  8. ncbi Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development
    B Hurle
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    Genomics 77:189-99. 2001

Scientific Experts

  • C A Ghiani
  • Luanne L Peters
  • Jennifer Larimore
  • Jean Francois Pare
  • Babette Gwynn
  • Victor Faundez
  • Yoland Smith
  • Karen Newell-Litwa
  • Minako Yoshida
  • Juan S Bonifacino
  • William A Gahl
  • Marjan Huizing
  • Kengo Moriyama
  • Steven L Ciciotte
  • Thuyen Nguyen
  • B Hurle
  • Stephanie A Zlatic
  • Avanti Gokhale
  • Branch Craige
  • Konrad Talbot
  • Pearl V Ryder
  • JOSHUA D LEE
  • Karine Tornieri
  • LeeAnne McGaha
  • Susan Jenkins
  • Sreenivasulu Chintala
  • Kazutaka Maeyama
  • Shoko Iwaki
  • Masao Ono
  • Norimasa Arita
  • Takaaki Hato
  • Miho Terada
  • Kan Saiga
  • Takahito Tsubaki
  • Masato Nose
  • Toshiyuki Niiya
  • Hiroaki Komori
  • Kyuichi Nemoto
  • Hiroshi Furukawa
  • Amanda Helip-Wooley
  • M Lynn Lamoreux
  • Lisa S Webb
  • Elena V Sviderskaya
  • Jose A Martina
  • Amy J Lambert
  • Dorothy C Bennett
  • Joachim Fluhr
  • Maryam Kermani
  • Maria L Wei
  • Richard T Swank
  • Edward K Novak
  • D M Ornitz
  • L M Tarantino
  • J Kenney
  • K Lane
  • B H Brownstein
  • M Bucan

Detail Information

Publications8

  1. ncbi Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex
    Babette Gwynn
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Blood 104:3181-9. 2004
    ..biogenesis of lysosome-related organelles complex 1 (BLOC-1), consisting of 4 HPS proteins (pallidin, muted, cappuccino, HPS7/sandy); BLOC-2, consisting of HPS6/ruby-eye, HPS5/ruby-eye-2, and HPS3/cocoa; and BLOC-3, consisting of ..
  2. pmc Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus
    Karen Newell-Litwa
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 30:820-31. 2010
    ..We propose that anatomically restricted mechanisms within the brain diversify the biogenesis and composition of synaptic vesicles...
  3. ncbi Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1)
    Steven L Ciciotte
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 101:4402-7. 2003
    ..Here, we report the cloning of the mouse HPS mutation cappuccino (cno)...
  4. pmc The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth
    C A Ghiani
    Mental Retardation Research Center, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 7332, USA
    Mol Psychiatry 15:115, 204-15. 2010
    ....
  5. pmc The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse
    Jennifer Larimore
    Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 22:4854-67. 2011
    ..Our findings indicate a novel vesicle transport mechanism requiring BLOC-1 and AP-3 complexes for cargo sorting from neuronal cell bodies to neurites and nerve terminals...
  6. ncbi Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development
    Thuyen Nguyen
    Department of Dermatology, Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    J Invest Dermatol 119:1156-64. 2002
    ..characterized by the step at which melanosome biogenesis or transfer to keratinocytes is inhibited, with the cappuccino strain observed to be blocked at the earliest step and gunmetal blocked at the latest step...
  7. ncbi Cappuccino mutation in an autoimmune-prone strain of mice suggests a role of platelet function in the progression of immune complex crescentic glomerulonephritis
    Minako Yoshida
    Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Arthritis Rheum 54:2934-43. 2006
    ..This study was undertaken in an attempt to identify the events that are critical for crescent formation in immune complex crescentic glomerulonephritis (CGN) by analyzing a novel mutant strain of mice...
  8. ncbi Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development
    B Hurle
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    Genomics 77:189-99. 2001
    ..3-p15 region. This analysis identified an inversion between the mouse and human genomes that places tlt and DFNA6/14 in close proximity...