Bglap

Summary

Gene Symbol: Bglap
Description: bone gamma carboxyglutamate protein
Alias: BGP, Bglap1, OG1, mOC-A, osteocalcin, bone Gla protein, bone gamma carboxyglutamate protein 1, gamma-carboxyglutamic acid-containing protein
Species: mouse

Top Publications

  1. ncbi Increased bone formation in osteocalcin-deficient mice
    P Ducy
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 382:448-52. 1996
  2. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
  3. pmc Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
    S Takeda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 15:467-81. 2001
  4. ncbi Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis
    Elazar Zelzer
    Harvard Medical School, Department of Cell Biology, 240 Longwood Avenue, Boston, MA, USA
    Development 129:1893-904. 2002
  5. ncbi A twist code determines the onset of osteoblast differentiation
    Peter Bialek
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Cell 6:423-35. 2004
  6. ncbi Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning
    T Yoshizawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Nat Genet 16:391-6. 1997
  7. ncbi Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5
    D Acampora
    International Institute of Genetic and Biophysics, CNR, Via Marconi 10, Italy
    Development 126:3795-809. 1999
  8. pmc Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    B St-Jacques
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:2072-86. 1999
  9. ncbi Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
    I Satokata
    Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 24:391-5. 2000
  10. ncbi The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    Kazuhisa Nakashima
    Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 108:17-29. 2002

Research Grants

  1. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
  2. ALTERED ETHANOL EFFECTS ON OSTEOCALCIN NULL MUTANT MICE
    Patricia Patterson Buckendahl; Fiscal Year: 2006
  3. Micro-computed tomography system (Micro-CT)
    Adele Boskey; Fiscal Year: 2008
  4. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2005
  5. CHONDROGENESIS AND HISTONE MODIFICATION ENZYMES
    Liu Yang; Fiscal Year: 2007
  6. OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICS
    Adele Boskey; Fiscal Year: 2003
  7. Regulation of parietal bone differentiation
    Venkatesh Govindarajan; Fiscal Year: 2007
  8. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2009
  9. Molecular Regulation of Ocular Gland Development
    Venkatesh Govindarajan; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. ncbi Increased bone formation in osteocalcin-deficient mice
    P Ducy
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 382:448-52. 1996
    ..To investigate the role of osteocalcin, the most abundant osteoblast-specific non-collagenous protein, we have generated osteocalcin-deficient mice...
  2. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
    ..Although immature osteoblasts, which expressed alkaline phophatase weakly but not Osteopontin and Osteocalcin, and a few immature osteoclasts appeared at the perichondrial region, neither vascular nor mesenchymal cell ..
  3. pmc Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
    S Takeda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 15:467-81. 2001
    ..These results identify Cbfa1 as a hypertrophic chondrocyte differentiation factor and provide a genetic argument for a common regulation of osteoblast and chondrocyte differentiation mediated by Cbfa1...
  4. ncbi Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis
    Elazar Zelzer
    Harvard Medical School, Department of Cell Biology, 240 Longwood Avenue, Boston, MA, USA
    Development 129:1893-904. 2002
    ..We also describe new in vivo evidence for a possible role of VEGF in chondrocyte maturation, and document that VEGF has a direct role in regulating osteoblastic activity based on in vivo evidence and organ culture experiments...
  5. ncbi A twist code determines the onset of osteoblast differentiation
    Peter Bialek
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Cell 6:423-35. 2004
    ..In vivo mutagenesis confirms the antiosteogenic function of the Twist box. Thus, relief of inhibition by Twist proteins is a mandatory event precluding osteoblast differentiation...
  6. ncbi Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning
    T Yoshizawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Nat Genet 16:391-6. 1997
    ..These defects, such as alopoecia and uterine hypoplasia, were not observed in vitamin D-deficient animals. The findings establish a critical role for VDR in growth, bone formation and female reproduction in the post-weaning stage...
  7. ncbi Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5
    D Acampora
    International Institute of Genetic and Biophysics, CNR, Via Marconi 10, Italy
    Development 126:3795-809. 1999
    ..The defects observed in Dlx5-/- mutant animals suggest multiple and independent roles of this gene in the patterning of the branchial arches, in the morphogenesis of the vestibular organ and in osteoblast differentiation...
  8. pmc Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    B St-Jacques
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:2072-86. 1999
    ..Together, the results suggest a model in which Ihh coordinates diverse aspects of skeletal morphogenesis through PTHrP-dependent and independent processes...
  9. ncbi Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
    I Satokata
    Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 24:391-5. 2000
    ..Our results provide a developmental basis for PFM and demonstrate that Msx2 is essential at multiple sites during organogenesis...
  10. ncbi The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    Kazuhisa Nakashima
    Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 108:17-29. 2002
    ..Thus, Osx acts downstream of Runx2/Cbfa1. Because Osx null preosteoblasts express typical chondrocyte marker genes, we propose that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells...
  11. ncbi Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation
    Yingzi Yang
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institute of Health, Bethesda, MD 20892, USA
    Development 130:1003-15. 2003
    ..Our data indicate that Wnt5a and Wnt5b control the pace of transitions between different chondrocyte zones...
  12. ncbi Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    Kai Yu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Development 130:3063-74. 2003
    ..Although differentiation of the osteoblast lineage was not disturbed, the proliferation of osteoprogenitors and the anabolic function of mature osteoblasts were severely affected...
  13. pmc Interactions between Sox9 and beta-catenin control chondrocyte differentiation
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:1072-87. 2004
    ..Our results strongly suggest that chondrogenesis is controlled by interactions between Sox9 and the Wnt/beta-catenin signaling pathway...
  14. ncbi Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification
    Lydia Koziel
    Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Dev Cell 6:801-13. 2004
    ..Finally, we propose that the development of exostoses in the human Hereditary Multiple Exostoses syndrome can be attributed to activation of Ihh signaling...
  15. ncbi Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    Hongliang Hu
    Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
    Development 132:49-60. 2005
    ..Finally Wnt7b is identified as a potential endogenous ligand regulating osteogenesis. These data support a model that integrates Hh and Wnt signaling in the regulation of osteoblast development...
  16. ncbi Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development
    Celine Colnot
    Department of Orthopaedic Surgery, University of California, San Francisco, California 94143 0514, USA
    Development 132:1057-67. 2005
    ....
  17. ncbi Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes
    Theo P Hill
    Research Institute for Molecular Pathology, Vienna, Austria
    Dev Cell 8:727-38. 2005
    ..Thus, canonical Wnt/beta-catenin signaling is essential for skeletal lineage differentiation, preventing transdifferentiation of osteoblastic cells into chondrocytes...
  18. pmc Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation
    Anne L Jacob
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 296:315-28. 2006
    ..These data demonstrate that signaling through FGFR1 in osteoblasts is necessary to maintain the balance between bone formation and remodeling through a direct effect on osteoblast maturation...
  19. pmc Nell-1-induced bone regeneration in calvarial defects
    Tara Aghaloo
    Dental and Craniofacial Research Institute, Department of Bioengineering, School of Dentistry, University of California, Los Angeles, 10833 Le Conte Ave, CHS 30 117, Los Angeles, CA 90095, USA
    Am J Pathol 169:903-15. 2006
    ..immunohistochemistry indicated that Nell-1 reduced osterix-producing cells and increased bone sialoprotein, osteocalcin, and BMP-7 expression...
  20. pmc Dominance of SOX9 function over RUNX2 during skeletogenesis
    Guang Zhou
    Howard Hughes Medical Institute and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:19004-9. 2006
    ..In summary, SOX9 is dominant over RUNX2 function in mesenchymal precursors that are destined for a chondrogenic lineage during endochondral ossification...
  21. pmc Endocrine regulation of energy metabolism by the skeleton
    Na Kyung Lee
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 130:456-69. 2007
    ..In contrast, mice lacking the osteoblast-secreted molecule osteocalcin display decreased beta-cell proliferation, glucose intolerance, and insulin resistance...
  22. pmc Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
    Mathieu Ferron
    Departments of Genetics and Development and Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:5266-70. 2008
    The osteoblast-specific secreted molecule osteocalcin behaves as a hormone regulating glucose metabolism and fat mass in two mutant mouse strains...
  23. pmc The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity
    Eiichi Hinoi
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Cell Biol 183:1235-42. 2008
    The osteoblast-secreted molecule osteocalcin favors insulin secretion, but how this function is regulated in vivo by extracellular signals is for now unknown...
  24. pmc The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization
    Kyu Sang Joeng
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 136:4177-85. 2009
    ..These results therefore provide direct genetic evidence that Gli2 and Gli3 collectively mediate all major aspects of Ihh function during endochondral skeletal development...
  25. pmc Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
    Mathieu Ferron
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 142:296-308. 2010
    ..expressing this receptor is the osteoblast, a bone-specific cell favoring glucose metabolism through a hormone, osteocalcin, that becomes active once uncarboxylated...
  26. pmc Sclerostin is a direct target of osteoblast-specific transcription factor osterix
    Fan Yang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA
    Biochem Biophys Res Commun 400:684-8. 2010
    ..Taken together, these findings support our hypothesis that Sost is a direct target of Osx. This provides a new additional mechanism through which Osx inhibits Wnt signaling during bone formation...
  27. pmc Endocrine regulation of male fertility by the skeleton
    Franck Oury
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Cell 144:796-809. 2011
    ..Analyses of cell-specific loss- and gain-of-function models reveal that the osteoblast-derived hormone osteocalcin performs this endocrine function...
  28. pmc Role of Indian hedgehog signaling in palatal osteogenesis
    Benjamin Levi
    Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, Calif, USA
    Plast Reconstr Surg 127:1182-90. 2011
    ..The authors hypothesize that Indian hedgehog activity plays a role in osteogenesis within the secondary palate and that defects in this pathway may inhibit osteogenesis of the secondary palate...
  29. pmc Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo
    Kyu Sang Joeng
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 359:222-9. 2011
    ..Thus, Lrp5 and 6 redundantly control embryonic skeletal development, likely through β-catenin signaling...
  30. pmc Osteoblast-specific transcription factor Osterix increases vitamin D receptor gene expression in osteoblasts
    Chi Zhang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS ONE 6:e26504. 2011
    ..They further provide new insight into potential mechanisms and pathways that Osx controls in osteoblasts and during the process of osteoblastic cell differentiation...
  31. pmc Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts
    Wanjin Tang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, Dallas, Texas 75219, USA
    J Biol Chem 287:1671-8. 2012
    ..results revealed that VEGF expression was down-regulated in Osx-null calvarial cells and that osteoblast marker osteocalcin expression was absent...
  32. pmc Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis
    Franck Oury
    Department of Genetics and Development, Columbia University, New York, New York, USA
    J Clin Invest 123:2421-33. 2013
    The osteoblast-derived hormone osteocalcin promotes testosterone biosynthesis in the mouse testis by binding to GPRC6A in Leydig cells...
  33. pmc Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene
    P Ducy
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030
    Mol Cell Biol 15:1858-69. 1995
    ..To understand these mechanisms, we analyzed the cis-acting elements of mouse osteocalcin gene 2 (mOG2), the best-characterized osteoblast-specific gene, by DNA transfection experiments in osteoblastic ..
  34. ncbi Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development
    Nathan Smith
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Cell Physiol 203:133-43. 2005
    ....
  35. pmc Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:14665-70. 2005
    ..Thus, our results strongly suggest that all osteo-chondroprogenitor cells, as well as progenitors in a variety of tissues, are derived from Sox9-expressing precursors during mouse embryogenesis...
  36. ncbi Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8
    C M Lutz
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 41:498-500. 1997
    ....
  37. pmc Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment
    Ke Wang
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Biol Chem 279:53848-56. 2004
    ..EGFR signaling regulated osteoclast formation. Inhibition of EGFR tyrosine kinase activity decreased the generation of osteoclasts from cultured bone marrow cells...
  38. ncbi MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    Michael A Arnold
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 12:377-89. 2007
    ..These findings reveal unexpected commonalities in the mechanisms governing muscle, cardiovascular, and bone development with respect to their regulation by MEF2 and class II HDACs...
  39. pmc Site-1 protease is essential for endochondral bone formation in mice
    Debabrata Patra
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, USA
    J Cell Biol 179:687-700. 2007
    ..These data suggest that S1P activity is necessary for a specialized ER stress response required by chondrocytes for the genesis of normal cartilage and thus endochondral ossification...
  40. pmc Brachy-syndactyly caused by loss of Sfrp2 function
    Roy Morello
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Physiol 217:127-37. 2008
    ....
  41. doi Neuropeptide Y expression and function during osteoblast differentiation--insights from transthyretin knockout mice
    Ana F Nunes
    Nerve Regeneration, IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal
    FEBS J 277:263-75. 2010
    ....
  42. pmc Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 11:161-71. 2010
    ..Our findings indicate that the full actions of PTH require intact Wnt signaling but that PTH can activate the Wnt pathway despite overexpression of Dkk1...
  43. pmc A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization
    Zohreh Khavandgar
    Faculty of Dentistry, McGill University, Montreal, Quebec QC H3A 1A4, Canada
    J Cell Biol 194:277-89. 2011
    ..Our data suggest tissue-specific roles for nSMase2 in skeletal tissues...
  44. pmc Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow
    Anna Mansour
    Universite de Nice Sophia Antipolis, 06000 Nice, France
    J Exp Med 209:537-49. 2012
    ..These findings broaden our knowledge of the HSC niche formation, which is critical for understanding normal and pathological hematopoiesis...
  45. pmc Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a
    Jianwen Wei
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY
    Diabetes 63:1021-31. 2014
    ..Here we show that osteocalcin, a bone-derived hormone, regulates β-cell replication in a cyclin D1-dependent manner by signaling through the ..
  46. pmc The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing
    Aline Heilmann
    Institute of Orthopaedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Ulm, Germany
    PLoS ONE 8:e84232. 2013
    ..The finding that Fzd9, in addition to its role in physiological bone remodeling, regulates bone repair may have implications for the development of treatments for poorly or non-healing fractures...
  47. pmc GGCX and VKORC1 inhibit osteocalcin endocrine functions
    Mathieu Ferron
    Unité de recherche en physiologie intégrative et moléculaire, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada Département de Médecine, Département de Biochimie et Médecine Moléculaire, and Programmes de biologie moléculaire, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada Département de Médecine, Département de Biochimie et Médecine Moléculaire, and Programmes de biologie moléculaire, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada Département de Médecine, Département de Biochimie et Médecine Moléculaire, and Programmes de biologie moléculaire, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec H3A 1A3, Canada
    J Cell Biol 208:761-76. 2015
    b>Osteocalcin (OCN) is an osteoblast-derived hormone favoring glucose homeostasis, energy expenditure, male fertility, brain development, and cognition...
  48. pmc Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation
    Jianwen Wei
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 161:1576-91. 2015
    ..These results reveal an unexpected intricacy between bone and glucose metabolism...
  49. doi Delayed osteoblastic differentiation and bone development in Cx43 knockout mice
    Lucas Martins Chaible
    Department of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil
    Toxicol Pathol 39:1046-55. 2011
    ..analyses were performed in order to assess the expression of markers associated with bone development, namely, osteocalcin, osteopontin, alkaline phosphatase, RUNX2, GJA1, GJC1 (Cx45), and GJA3 (Cx46)...
  50. pmc Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development
    Anat Kohn
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Development 139:1198-212. 2012
    ..Finally, cartilage-specific RBPjκ-independent Notch signaling likely regulates Ihh responsiveness during cartilage and bone development...
  51. pmc The Sox2 high mobility group transcription factor inhibits mature osteoblast function in transgenic mice
    Greg Holmes
    Department of Microbiology, New York University School of Medicine, 550 1st Ave, New York, NY 10016, USA
    Bone 49:653-61. 2011
    ..Our results position Sox2 as a negative regulator of osteoblast maturation in vivo...
  52. pmc Role of GSK-3β in the osteogenic differentiation of palatal mesenchyme
    Emily R Nelson
    Hagey Laboratory for Pediatric Regenerative Medicine, Plastic and Reconstructive Surgery Division, Department of Surgery, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 6:e25847. 2011
    ..Using GSK-3ß null mouse embryos, we examine the potential coordinate roles of Wnt and Hedgehog signaling on palatal ossification...
  53. pmc Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh
    Weiguang Wang
    Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Development 139:601-11. 2012
    Atf4 is a leucine zipper-containing transcription factor that activates osteocalcin (Ocn) in osteoblasts and indian hedgehog (Ihh) in chondrocytes...
  54. doi Krüppel-like factor 4 regulates membranous and endochondral ossification
    Ikumi Michikami
    Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Yamadaoka 1 8, Suita, Osaka, 565 0871, Japan
    Exp Cell Res 318:311-25. 2012
    ..Significantly, osteocalcin, which is known to chemotact osteoclasts, was up-regulated at the perichindrium as early as E14...
  55. doi Decreased sensory responses in osteocalcin null mutant mice imply neuropeptide function
    Patricia Patterson-Buckendahl
    Center of Alcohol Studies Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cell Mol Neurobiol 32:879-89. 2012
    b>Osteocalcin, the most abundant member of the family of extracellular mineral binding gamma-carboxyglutamic acid proteins is synthesized primarily by osteoblasts. Its affinity for calcium ions is believed to limit bone mineralization...
  56. doi MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis
    Kui Ming Chan
    Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China
    Dev Cell 22:1176-90. 2012
    ..These data reveal a regulatory paradigm for FGRF2 signaling and identify MT1-MMP as a critical negative modulator of ADAM9 activity to maintain FGFR2 signaling in calvarial osteogenesis...
  57. ncbi Chromosomal assignment in mouse of matrix Gla protein and bone Gla protein genes
    T L Johnson
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284
    Genomics 11:770-2. 1991
    Matrix Gla protein (MGLAP) and bone Gla protein (BGLAP) are calcium-binding, vitamin K-dependent proteins produced by cells of the osteoblastic lineage...
  58. ncbi Genetic mapping of the tumor-associated mucin 1 gene on mouse chromosome 3
    S F Kingsmore
    Department of Medicine, University of Florida, Gainesville 32610, USA
    Mamm Genome 6:378-9. 1995
  59. ncbi Expression of mRNA of murine bone-related proteins in ectopic bone induced by murine bone morphogenetic protein-4
    S Hirota
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Cell Tissue Res 277:27-32. 1994
    ..A strong osteocalcin mRNA signal was detected in osteoblast-like cells from the middle to late stages and in a limited subset of ..
  60. pmc Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation
    N Amizuka
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Cell Biol 126:1611-23. 1994
    ....
  61. ncbi Dependence of induction of osteocalcin gene expression on the presence of wild-type p53 in a murine osteosarcoma cell line
    N Chandar
    Orthopedic Research Laboratory, Allegheny Singer Research Institute, Pittsburgh, PA 15212
    Mol Carcinog 8:299-305. 1993
    ..Alkaline phosphatase and osteocalcin expression were measured as early and late differentiation markers, respectively...
  62. ncbi The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression
    C Desbois
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030
    J Biol Chem 269:1183-90. 1994
    b>Osteocalcin is the most abundant noncollagenous protein of bone. Here we report that the mouse genome contains an osteocalcin cluster composed of three genes arranged within a 23-kilobase span of genomic DNA...
  63. ncbi Study of osteoblast-specific expression of one mouse osteocalcin gene: characterization of the factor binding to OSE2
    P Ducy
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Connect Tissue Res 35:7-14. 1996
    ..attempt to understand the mechanisms of osteoblast-specific expression, we analyzed the promoter of the mouse osteocalcin gene 2, an osteoblast-specific gene...
  64. ncbi Human and murine osteocalcin gene expression: conserved tissue restricted expression and divergent responses to 1,25-dihydroxyvitamin D3 in vivo
    N A Sims
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Mol Endocrinol 11:1695-708. 1997
    Human and murine osteocalcin genes demonstrate similar cell-specific expression patterns despite significant differences in gene locus organization and sequence variations in cis-acting regulatory elements...
  65. ncbi Analysis of osteocalcin expression in transgenic mice reveals a species difference in vitamin D regulation of mouse and human osteocalcin genes
    T L Clemens
    Department of Medicine, University of Cincinnati, Ohio, U S A
    J Bone Miner Res 12:1570-6. 1997
    A line of transgenic mice expressing a human osteocalcin genomic fragment (hOClocus) and a murine MC3T3-E1 cell line containing a stably integrated human osteocalcin promoter construct have been developed to characterize the osteogenic ..
  66. ncbi The Atp1b3 gene for Na,K-ATPase beta 3 subunit maps to mouse chromosome 9, and a related gene, Atp1b3-rs, maps to mouse chromosome 3
    C G Besirli
    Kresge Hearing Research Institute, Department of Otolaryngology Head Neck Surgery, University of Michigan Medical School, Ann Arbor 48109 0648, USA
    Mamm Genome 9:171-2. 1998
  67. ncbi The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone
    B Lanske
    Endocrine Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 139:5194-204. 1998
    ..receptor (-/-) animals, but not PTHrP (-/-) animals, have decreased levels of collagenase 3, osteopontin, and osteocalcin messenger RNAs. The PTH/PTHrP receptor, therefore, mediates distinct physiologic actions of both PTH and PTHrP.
  68. ncbi Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers
    A F Ruchon
    Departement de Biochimie, Universite de Montreal, Canada
    J Bone Miner Res 15:1440-50. 2000
    ..against human PHEX, examined the effect of the Hyp mutation on Phex expression, and compared neprilysin (NEP), osteocalcin, and parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) receptor gene expression in bone of ..
  69. pmc Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development
    U I Chung
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom St, Boston, Massachusetts 02114, USA
    J Clin Invest 107:295-304. 2001
    ..By providing crucial local signals from prehypertrophic and hypertrophic chondrocytes to both chondrocytes and preosteoblasts, IHH couples chondrogenesis to osteogenesis in endochondral bone development...
  70. ncbi Impaired ossification in mice lacking the transcription factor Sp3
    H Gollner
    Institut fur Molekularbiologie und Tumorforschung, Emil Mannkopff Strasse 2, 35037, Marburg, Germany
    Mech Dev 106:77-83. 2001
    ..The delay in ossification is reflected by reduced expression of the osteoblast-specific marker gene osteocalcin. The transcription factor - core binding factor 1 (Cbfa1)--that is essential for bone formation, however, is ..
  71. pmc The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development
    Raymond F Robledo
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Genes Dev 16:1089-101. 2002
    ..Furthermore, spatiotemporal-specific transgenic overexpression of Dlx5, in the apical ectodermal ridge of Dlx5/6 null mice can fully rescue Dlx/Dll function in limb outgrowth...
  72. ncbi Core-binding factor beta interacts with Runx2 and is required for skeletal development
    Carolina A Yoshida
    Department of Molecular Medicine, Osaka University Medical School, 2 2 Yamada Oka Suita, Osaka 565 0871, Japan
    Nat Genet 32:633-8. 2002
    ..These findings indicate that Cbfbeta is required for the function of Runx2 in skeletal development...
  73. ncbi Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype
    Gethin Thomas
    Phenogene Therapeutics Inc, 416 de Maisonneuve West, Suite 1020, Montreal, Quebec H3A 1L2, Canada
    J Biol Chem 278:50563-71. 2003
    ..By in situ hybridization in mouse embryos, osteocrin was expressed specifically in Cbfa-1-positive, osteocalcin-negative osteoblasts...
  74. ncbi Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene
    I Kalajzic
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    Bone 35:74-82. 2004
    ..Generation of this transgenic model will facilitate studies of gene expression and biological functions in these terminally differentiated bone cells...
  75. ncbi The tyrosine phosphatase, OST-PTP, is expressed in mesenchymal progenitor cells early during skeletogenesis in the mouse
    Laurie A Yunker
    Graduate Program in Molecular Veterinary Biosciences, University of Minnesota, St Paul, 55108 USA
    J Cell Biochem 93:761-73. 2004
    ..Early in embryogenesis, regulation of OST expression may be independent of Runx2/Cbfa1...
  76. ncbi The homeoprotein engrailed 1 has pleiotropic functions in calvarial intramembranous bone formation and remodeling
    Ron A Deckelbaum
    Department of Cell Biology, New York University School of Medicine, MSB room 614, 550 1st Avenue, New York, NY 10016, USA
    Development 133:63-74. 2006
    ..In summary, this study identifies EN1 as a novel modulator of calvarial osteoblast differentiation and proliferation, processes that must be exquisitely balanced to ensure proper skull vault formation...
  77. pmc FGF9 can induce endochondral ossification in cranial mesenchyme
    Venkatesh Govindarajan
    Cancer Center, Creighton University, Omaha, NE 68178, USA
    BMC Dev Biol 6:7. 2006
    ..This type of ossification is distinct from endochondral ossification, a process that involves initial formation of cartilage and later replacement by bone...
  78. pmc FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod
    Irene H Hung
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 307:300-13. 2007
    ..In developing stylopod elements, FGF9 promotes chondrocyte hypertrophy at early stages and regulates vascularization of the growth plate and osteogenesis at later stages of skeletal development...
  79. ncbi Requirement for ErbB2/ErbB signaling in developing cartilage and bone
    Melanie C Fisher
    Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030, USA
    Dev Growth Differ 49:503-13. 2007
    ..Our study identifies requirements for ErbB signaling in the maintenance of chondrocyte and osteoblast proliferation involved in the timely progression of chondrocyte maturation and periosteal osteoblast differentiation...
  80. ncbi Marfan-like skeletal phenotype in the tight skin (Tsk) mouse
    Tatjana Barisic-Dujmovic
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Calcif Tissue Int 81:305-15. 2007
    ..These initial experiments demonstrated a significant role of the fibrillin 1 protein in the extracellular matrix of bone cells...
  81. pmc Hand transcription factors cooperatively regulate development of the distal midline mesenchyme
    Ana C Barbosa
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Dev Biol 310:154-68. 2007
    ..These findings demonstrate the importance of Hand transcription factors in the transcriptional circuitry of craniofacial and tooth development...
  82. ncbi Cell fate specification during calvarial bone and suture development
    Eva Lana-Elola
    Departments of Craniofacial Development and Orthodontics, Floor 27 Guy s Tower, King s College, London, SE1 9RT, UK
    Dev Biol 311:335-46. 2007
    ....
  83. pmc Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin
    Qiuqian Wu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Bone Miner Res 23:552-63. 2008
    ..The mechanism underlying Smurf2-mediated morphological changes during embryonic development may provide new mechanistic insights and potential targets for prevention and treatment of human osteoarthritis...
  84. pmc Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia
    Xuehui Yang
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, Maine 04074, USA
    Dev Biol 321:64-76. 2008
    ....
  85. pmc Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation
    Steven Pregizer
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California, USA
    J Cell Biochem 105:965-70. 2008
    The mRNAs encoding Runx2, a master osteoblast transcription factor, and its target gene Osteocalcin (OC), are commonly used as markers of osteoblast differentiation...
  86. doi Transactivation by Runt related factor-2 of matrix metalloproteinase-13 in astrocytes
    Takeshi Takarada
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
    Neurosci Lett 451:99-104. 2009
    ..and their targets such as osteopontin (OPN) and matrix metalloproteinase-13 (MMP13), but not for collagen-I or osteocalcin. In pluripotent P19 progenitor cells, Runx2 mRNA expression was drastically increased along with mRNA ..
  87. pmc Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development
    Tomoya Matsunobu
    Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Dev Biol 332:325-38. 2009
    ..These results demonstrate the important roles of TGF-beta signaling in perichondrium formation and differentiation, as well as in growth plate integrity during skeletal development...
  88. pmc Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures
    Laura W Gamer
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Dev Dyn 238:2374-81. 2009
    ....
  89. pmc Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis
    Takehiko Matsushita
    Department of Orthopaedics, Case Western Reserve University, 2109 Adelbert Road, BRB 329, Cleveland, OH 44106, USA
    Mol Cell Biol 29:5843-57. 2009
    ..Thus, our results indicate that ERK1 and ERK2 not only play essential roles in the lineage specification of osteo-chondroprogenitor cells but also support osteoclast formation in vivo...
  90. pmc Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium
    EMBO J 29:424-41. 2010
    ..Moreover, the finding that VEGF can modulate beta-catenin activity may have widespread physiological and clinical ramifications...
  91. pmc FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
    Marie Therese Rached
    Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Clin Invest 120:357-68. 2010
    Osteoblasts have recently been found to play a role in regulating glucose metabolism through secretion of osteocalcin. It is unknown, however, how this osteoblast function is regulated transcriptionally...
  92. pmc Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation
    Yoshimi Tokuzawa
    Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, Japan
    PLoS Genet 6:e1001019. 2010
    ..The new role of Id4 in promoting osteoblast differentiation renders it a target for preventing the onset of senile osteoporosis...
  93. pmc Mitogen-activated protein kinase phosphatase 1 regulates bone mass, osteoblast gene expression, and responsiveness to parathyroid hormone
    Chandrika D Mahalingam
    Division of Endocrinology, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Endocrinol 211:145-56. 2011
    ..Histomorphometric analysis showed decreased trabecular bone area in KO females. Levels of serum osteocalcin (OCN) were lower and serum tartrate-resistant acid phosphatase 5b (TRAP5b) was higher in KO animals...
  94. pmc Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones
    A J Celeste
    EMBO J 5:1885-90. 1986
    cDNAs which encode bone gla protein (BGP), an abundant gamma-carboxylated protein of bone, have been cloned from rat and mouse osteosarcoma cell lines...
  95. ncbi Localization of the osteocalcin gene cluster on mouse chromosome 3
    C Desbois
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030
    Mamm Genome 5:321-2. 1994
  96. ncbi 1,25-dihydroxyvitamin D3 inhibits Osteocalcin expression in mouse through an indirect mechanism
    R Zhang
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Biol Chem 272:110-6. 1997
    ..In particular, in rat and human osteoblasts, 1,25-(OH)2D3 increases the expression of Osteocalcin by interacting, through a hormone-receptor complex, with a vitamin D-responsive element present in the promoter ..
  97. ncbi Reciprocal temporospatial patterns of Msx2 and Osteocalcin gene expression during murine odontogenesis
    M Bidder
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 13:609-19. 1998
    Msx2 is a homeodomain transcription factor that regulates craniofacial development in vivo and osteocalcin (Osc) promoter activity in vitro...
  98. ncbi Does adult fracture repair recapitulate embryonic skeletal formation?
    C Ferguson
    Department of Orthopaedic Surgery, University of California at San Francisco, 533 Parnassus Ave, San Francisco, USA
    Mech Dev 87:57-66. 1999
    ..cell condensation, chondrocyte (ihh, cbfa1 and collagen type II-positive) and perichondrial (gli1 and osteocalcin-positive) cell populations were already specified...
  99. ncbi A molecular analysis of matrix remodeling and angiogenesis during long bone development
    C I Colnot
    Department of Orthopedic Surgery, University of California at San Francisco, CA 94143 0514, USA
    Mech Dev 100:245-50. 2001
    ..Here, we have produced a 'molecular map' of the initial vascularization of the developing skeleton that provides a framework in which to interpret a wide range of fetal skeletal malformations, disruptions, and dysplasias...
  100. ncbi Differential expression patterns of Runx2 isoforms in cranial suture morphogenesis
    M H Park
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Taegu, Korea
    J Bone Miner Res 16:885-92. 2001
    ..expressed in the osteogenic fronts, as well as in developing parietal bones, where osteopontin (OP) and osteocalcin (OC) also were expressed...
  101. pmc Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18
    Zhonghao Liu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 16:859-69. 2002
    ..These data demonstrate that FGF18 signals through another FGFR to regulate osteoblast growth. Signaling to multiple FGFRs positions FGF18 to coordinate chondrogenesis in the growth plate with osteogenesis in cortical and trabecular bone...

Research Grants9

  1. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
  2. ALTERED ETHANOL EFFECTS ON OSTEOCALCIN NULL MUTANT MICE
    Patricia Patterson Buckendahl; Fiscal Year: 2006
    Preliminary data showed that preference for and consumption of alcohol (EtOH) by osteocalcin (OC) null mutant mice (KO) differs significantly from wildtype C57BL/6 (WT) mice...
  3. Micro-computed tomography system (Micro-CT)
    Adele Boskey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  4. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2005
    ..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
  5. CHONDROGENESIS AND HISTONE MODIFICATION ENZYMES
    Liu Yang; Fiscal Year: 2007
    ....
  6. OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICS
    Adele Boskey; Fiscal Year: 2003
    ..The proposed studies will be based on histology, FTIR Imaging (FTIRI), biomechanical, and biochemical techniques and represent a novel approach to evaluating the organic matrix inosteoporosis. ..
  7. Regulation of parietal bone differentiation
    Venkatesh Govindarajan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  8. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2009
    ....
  9. Molecular Regulation of Ocular Gland Development
    Venkatesh Govindarajan; Fiscal Year: 2010
    ..In addition, the proposed studies will, in the long-term, allow the development of novel therapeutic approaches for treatment of patients with dry eye syndromes. ..