beta-galactosidase

Summary

Gene Symbol: beta-galactosidase
Description: galactosidase, beta 1
Alias: AW125515, Bge, Bgl, Bgl-e, Bgl-s, Bgl-t, Bgs, Bgt, C130097A14Rik, beta-galactosidase, acid beta-galactosidase, lactase
Species: mouse

Top Publications

  1. ncbi Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis
    J Matsuda
    Department of Veterinary Science, National Institute of Health, Tokyo, Japan
    Glycoconj J 14:729-36. 1997
  2. ncbi Progressive restriction of cell fates in relation to neuroepithelial cell mingling in the mouse cerebellum
    Luc Mathis
    Unité de Biologie moléculaire du Développement, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Dev Biol 258:20-31. 2003
  3. pmc The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes
    James Harper
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 108:10585-90. 2011
  4. doi Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis
    Ayumi Takamura
    Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, 86 Nishi Machi, Yonago 683 8503, Japan
    Biochem Biophys Res Commun 367:616-22. 2008
  5. ncbi Generalized CNS disease and massive GM1-ganglioside accumulation in mice defective in lysosomal acid beta-galactosidase
    C N Hahn
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Hum Mol Genet 6:205-11. 1997
  6. doi Urinary β-galactosidase stimulates Ca2+ transport by stabilizing TRPV5 at the plasma membrane
    Elizabeth H P Leunissen
    Department of Physiology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen 6500 HB, The Netherlands
    Glycobiology 26:472-81. 2016
  7. pmc Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses
    Zeynep Akgoc
    Department of Biology, Boston College, Chestnut Hill, MA 02467
    J Lipid Res 56:1006-13. 2015
  8. pmc Senescence-associated β-galactosidase activity marks the visceral endoderm of mouse embryos but is not indicative of senescence
    Tingting Huang
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts, 01655
    Genesis 52:300-8. 2014
  9. pmc Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity
    Marielle Boonen
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biol Cell 20:4381-9. 2009
  10. ncbi Reduced pigmentation (rp), a new coat colour gene with effects on kidney lysosomal glycosidases in the mouse
    S Gibb
    Genet Res 37:95-103. 1981

Scientific Experts

  • Jia Bin Sun
  • Melissa D Lambourne
  • Masayuki Itoh
  • J Matsuda
  • Barry Boland
  • ALESSANDRA D'AZZO
  • Renata Sano
  • Ayumi Takamura
  • Thomas N Seyfried
  • Yoshiyuki Suzuki
  • Elizabeth H P Leunissen
  • Zeynep Akgoc
  • Tingting Huang
  • Alessandra Tessitore
  • Sharon Zhou
  • Julian R Arthur
  • Joonseok Cho
  • James Harper
  • Alexandre Darmoise
  • Einat B Vitner
  • Katsumi Higaki
  • Haruaki Ninomiya
  • Eiji Nanba
  • Kousaku Ohno
  • Marielle Boonen
  • Elena Elliot-Smith
  • Christine A Denny
  • Yu Kyung Kim
  • Satoshi Ichinomiya
  • Frances M Platt
  • Jens Schumann
  • N Nowroozi
  • Terry D Butters
  • Stephan D Gadola
  • J L Kasperzyk
  • Angela Ingrassia
  • Fareeba Sheedfar
  • Jenny van der Wijst
  • Maxime G Blanchard
  • Luc Mathis
  • Marla Lavrijsen
  • Rene J M Bindels
  • Joost G J Hoenderop
  • Xianlin Han
  • Miguel Sena-Esteves
  • Douglas R Martin
  • Nakisa Nowroozi
  • Jaime A Rivera-Perez
  • K Suzuki
  • A D'AZZO
  • Elizabeth J Robertson
  • Robert McGlynn
  • Steven U Walkley
  • Marie T Vanier
  • Masami Iida
  • Sean Bong Lee
  • Hongjie Li
  • Arne Mould
  • Cristin Davidson
  • Tomoko Takai
  • Tao Cheng
  • Hui Yu
  • Kostantin Dobrenis
  • Robert M Andrews
  • Karie A Heinecke
  • Hongmei Shen
  • Elizabeth K Bikoff
  • Byeong Chel Lee
  • Gloria Stephney
  • Susann Teneberg
  • Hani Dekel
  • Florian Winau
  • Stefan Karlsson
  • Lauriane Bouzonville
  • Roscoe O Brady
  • Tamar Farfel-Becker
  • Raya Eilam
  • Michael Beck
  • Hila Zigdon
  • Anthony H Futerman
  • J Tohyama
  • Stefan H E Kaufmann
  • Tamar Shachar
  • Nancy Dahms
  • Simon Moshiach
  • Stuart Kornfeld
  • Michael Forte
  • Annette Patterson
  • Kenneth A Platt
  • Peter Vogel

Detail Information

Publications71

  1. ncbi Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis
    J Matsuda
    Department of Veterinary Science, National Institute of Health, Tokyo, Japan
    Glycoconj J 14:729-36. 1997
    ..Biochemical analysis revealed a marked accumulation of ganglioside GM1 and asialo GM1 in brain tissue. This animal model will be useful for pathogenetic analysis and therapeutic trial of human GM1-gangliosidosis...
  2. ncbi Progressive restriction of cell fates in relation to neuroepithelial cell mingling in the mouse cerebellum
    Luc Mathis
    Unité de Biologie moléculaire du Développement, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Dev Biol 258:20-31. 2003
    ..Together, the data demonstrate the broad maintenance of the relative order of cells from neural tube stages to the adult cerebellum...
  3. pmc The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes
    James Harper
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 108:10585-90. 2011
    ..In contrast, those required for processing maternal milk were markedly reduced. Thus, we conclude Blimp1 governs the developmental switch responsible for postnatal intestinal maturation...
  4. doi Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis
    Ayumi Takamura
    Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, 86 Nishi Machi, Yonago 683 8503, Japan
    Biochem Biophys Res Commun 367:616-22. 2008
    ..These results suggest activation of autophagy leading to mitochondrial dysfunction in the brain of G(M1)-gangliosidosis...
  5. ncbi Generalized CNS disease and massive GM1-ganglioside accumulation in mice defective in lysosomal acid beta-galactosidase
    C N Hahn
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Hum Mol Genet 6:205-11. 1997
    ..However, tremor, ataxia and abnormal gait become apparent in older mice. Thus, the beta-gal-deficient mice appear to mimic closely the pathological, biochemical and clinical abnormalities of the human disease...
  6. doi Urinary β-galactosidase stimulates Ca2+ transport by stabilizing TRPV5 at the plasma membrane
    Elizabeth H P Leunissen
    Department of Physiology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen 6500 HB, The Netherlands
    Glycobiology 26:472-81. 2016
    ..gal expression was detected in the apical membrane of the proximal tubules, and the protein was found in mouse urine. In summary, β-gal is present in the pro-urine from where it is thought to stimulate TRPV5 activity. ..
  7. pmc Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses
    Zeynep Akgoc
    Department of Biology, Boston College, Chestnut Hill, MA 02467
    J Lipid Res 56:1006-13. 2015
    ..The results show that BMP accumulates as a secondary storage material in the brain of a broad range of mammals with gangliosidoses. ..
  8. pmc Senescence-associated β-galactosidase activity marks the visceral endoderm of mouse embryos but is not indicative of senescence
    Tingting Huang
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts, 01655
    Genesis 52:300-8. 2014
    ..SA-β-gal serves as a practical marker of the dynamics of the visceral endoderm that can be applied to developmental as well as functional studies of early mammalian embryos...
  9. pmc Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity
    Marielle Boonen
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biol Cell 20:4381-9. 2009
    ....
  10. ncbi Reduced pigmentation (rp), a new coat colour gene with effects on kidney lysosomal glycosidases in the mouse
    S Gibb
    Genet Res 37:95-103. 1981
  11. doi B lymphocytes treated in vitro with antigen coupled to cholera toxin B subunit induce antigen-specific Foxp3(+) regulatory T cells and protect against experimental autoimmune encephalomyelitis
    Jia Bin Sun
    University of Gothenburg Vaccine Research Institute, Sahlgrenska Academy at the University of Gothenburg, SE 405 30, Goteborg, Sweden
    J Immunol 188:1686-97. 2012
    ..Our results suggest that B cells pulsed in vitro with relevant Ag/CTB conjugates may be used in cell therapy to induce Ag-specific suppression of autoimmune disease...
  12. doi Murine β-galactosidase stability is not dependent on temperature or protective protein/cathepsin A
    Melissa D Lambourne
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Mol Genet Metab 104:620-6. 2011
    ..Despite our attempts to improve the extracellular stability of human GLB1 through sequence modification and the use of chemical chaperone N-butyldeoxygalactonojirimycin, the specific enzyme activity remained well below that of mGLB1...
  13. ncbi The expression of Usp42 during embryogenesis and spermatogenesis in mouse
    Yu Kyung Kim
    Cell and Gene Therapy Research Institute, Graduate School of Life Science and Biotechnology, Pochon CHA University, CHA General Hospital, Seoul 135 081, Republic of Korea
    Gene Expr Patterns 7:143-8. 2007
    ..Taken all together, it is suggested that Usp42 is one of typical deubiquitinating enzymes, which may play an important role in mouse embryogenesis and spermatogenesis...
  14. pmc Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence
    Joonseok Cho
    University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    Blood 117:1156-66. 2011
    ....
  15. ncbi GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis
    Alessandra Tessitore
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Mol Cell 15:753-66. 2004
    ..These findings suggest that the UPR can be induced by accumulation of the sialoglycolipid GM1 and this causes a novel mechanism of neuronal apoptosis...
  16. ncbi Neurochemical, morphological, and neurophysiological abnormalities in retinas of Sandhoff and GM1 gangliosidosis mice
    Christine A Denny
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Neurochem 101:1294-302. 2007
    ..Our findings present a model system for assessing retinal pathobiology and therapies for the gangliosidoses...
  17. ncbi Motor and reflex testing in GM1-gangliosidosis model mice
    Satoshi Ichinomiya
    Graduate School, International University of Health and Welfare, Otawara, Japan
    Brain Dev 29:210-6. 2007
    ....
  18. pmc Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases
    Stephan D Gadola
    Weatherall Institute of Molecular Medicine, Tumour Immunology Group, John Radcliffe Hospital, Oxford OX3 9DS, England, UK
    J Exp Med 203:2293-303. 2006
    ..These data suggest that GSL storage may result in alterations in thymic selection of iNKT cells caused by impaired presentation of selecting ligands...
  19. pmc Chemokine-induced recruitment of genetically modified bone marrow cells into the CNS of GM1-gangliosidosis mice corrects neuronal pathology
    Renata Sano
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 106:2259-68. 2005
    ..Thus, a disease condition such as G(M1)-gangliosidosis, which is characterized by neurodegeneration and neuroinflammation, may influence the response of the CNS to ex vivo gene therapy...
  20. ncbi Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice
    J L Kasperzyk
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    J Lipid Res 46:744-51. 2005
    ....
  21. doi Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis
    Elena Elliot-Smith
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Mol Genet Metab 94:204-11. 2008
    ..However, functional improvement was greatest with NB-DNJ treatment which may potentially be caused by novel anti-inflammatory properties of NB-DNJ...
  22. ncbi Acidic beta-galactosidase in the developing mouse submandibular gland
    Nakisa Nowroozi
    Department of Orthodontics and Basic Sciences, School of Dentistry, University of Southern California, 925 West 34th Street, Los Angeles, CA 90089 0641, USA
    Arch Oral Biol 47:173-6. 2002
    ..The function of beta-gal in duct cells is unclear, but the change in the cellular distribution of beta-gal in the mouse submandibular gland could reflect a change in the substrate specificity of this enzyme between E18 and adulthood...
  23. ncbi Development of lysosomal storage in mice with targeted disruption of the beta-galactosidase gene: a model of human G(M1)-gangliosidosis
    M Itoh
    Department of Mental Retardation and Birth Defect Research, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi, Kodaira, 187 8502, Tokyo, Japan
    Brain Dev 23:379-84. 2001
    ..Although there are some phenotypic and biochemical differences between this knockout mouse and human GM1 gangliosidosis, the mouse will be a useful model for therapeutic trials for the human disease...
  24. ncbi Paradoxical influence of acid beta-galactosidase gene dosage on phenotype of the twitcher mouse (genetic galactosylceramidase deficiency)
    J Tohyama
    Neuroscience Center, University of North Carolina, Chapel Hill 27599 7250, USA
    Hum Mol Genet 9:1699-707. 2000
    ....
  25. ncbi Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
    D A Persons
    Department of Experimental Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Genet 23:159-65. 1999
    ..We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia...
  26. ncbi High levels of GM1-ganglioside beta-galactosidase in the salivary glands and GM1-like-ganglioside storage in parotids of deficient mice
    N Nowroozi
    School of Dentistry, University of Southern California, Los Angeles 90089 0641, USA
    J Craniofac Genet Dev Biol 19:41-7. 1999
    ..beta-gal may also serve in secretory glycoprotein catabolism in other salivary glands, but this function may be non-essential for these glands...
  27. ncbi Differential alteration of lipid antigen presentation to NKT cells due to imbalances in lipid metabolism
    Jens Schumann
    Experimental Immunology, Department of Research, University Hospital Basel, Basel, Switzerland
    Eur J Immunol 37:1431-41. 2007
    ..Based on these results, the impact of lipid accumulation should be generally considered in the interpretation of immunological deficiencies found in mice suffering from lipid metabolic disorders...
  28. ncbi Acid hydrolases as models of genetic control
    K Paigen
    Annu Rev Genet 13:417-66. 1979
  29. ncbi Two gene products for beta-galactosidase are differentially expressed in the mouse salivary glands
    N Nowroozi
    Department of Orthodontics, School of Dentistry, University of Southern California, Los Angeles 90089 0641, USA
    J Craniofac Genet Dev Biol 18:51-7. 1998
    ..Further studies of beta-galactosidase function and differential regulation in these tissues are needed...
  30. pmc Genetic determination of the developmental program for mouse liver beta-galactosidase: involvement of sites proximate to and distant from the structural gene
    F G Berger
    Genetics 92:1187-203. 1979
    ..type II developmental difference between strains C57BL/6J and DBA/2J is due to variation at a locus, Bgl-t, that maps with the beta-galactosidase complex, [Bgl], on chromosome 9...
  31. pmc GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis
    Renata Sano
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell 36:500-11. 2009
    ....
  32. doi Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses
    Einat B Vitner
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Hum Mol Genet 19:3583-90. 2010
    ....
  33. pmc Lysosomal alpha-galactosidase controls the generation of self lipid antigens for natural killer T cells
    Alexandre Darmoise
    Immune Disease Institute, Program in Cellular and Molecular Medicine at Children s Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 33:216-28. 2010
    ..Thus, we present TLR-dependent negative regulation of alpha-Gal-A as a mechanistic link between pathogen recognition and self lipid antigen induction for NKT cells...
  34. pmc Macroautophagy is not directly involved in the metabolism of amyloid precursor protein
    Barry Boland
    Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin 4, Ireland
    J Biol Chem 285:37415-26. 2010
    ..These data suggest that neuronal macroautophagy does not directly regulate APP metabolism but highlights the important anti-amyloidogenic role of lysosomal proteolysis in post-secretase APP-CTF catabolism...
  35. pmc Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain
    Julian R Arthur
    Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    J Lipid Res 52:1345-51. 2011
    ..The data indicate that in addition to cholesterol, filipin can also be useful for detecting GM1...
  36. doi Lysosomal accumulation of Trk protein in brain of GM₁ -gangliosidosis mouse and its restoration by chemical chaperone
    Ayumi Takamura
    Division of Functional Genomics, Research Center for Bioscience and Technology, Nishi cho, Yonago, Japan
    J Neurochem 118:399-406. 2011
    ..These findings indicate that G(M1) accumulation in rafts causes activation of Trk signaling, which may participate in the pathogenesis of G(M1) -gangliosidosis...
  37. ncbi Cis-active control of mouse beta-galactosidase biosynthesis by a systemic regulatory locus
    F G Berger
    Nature 282:314-6. 1979
    ..The rate of synthesis of beta-galactosidase in mouse tissues is under the control of a regulatory locus; Bgl-s, that is tightly linked to the enzyme structural gene; we have tested the cis/trans nature of Bgl-s action by ..
  38. pmc Endosomal/lysosomal processing of gangliosides affects neuronal cholesterol sequestration in Niemann-Pick disease type C
    Sharon Zhou
    Dominick P Purpura Department of Neuroscience, Rose F Kennedy Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 179:890-902. 2011
    ..These studies provide further evidence that NPC1 and NPC2 proteins participate in endosomal/lysosomal processing of both sphingolipids and cholesterol...
  39. ncbi Relationship between genetic variation in thermal stability and electrophoretic mobility of mouse beta-galactosidase
    F G Berger
    Biochem Genet 16:1007-14. 1978
    ..The evidence supports the notion that a single beta-galactosidase structural locus is expressed in all tissues and that the differences in enzyme stability between tissues results from posttranslational enzyme modification...
  40. ncbi Genetic control of cell-type-specific levels of mouse beta-galactosidase
    M J Dewey
    Dev Biol 66:560-3. 1978
  41. ncbi Regulation of the rate of beta-galactosidase synthese by the Bgs and Bgt loci in the mouse
    F G Berger
    J Biol Chem 253:5280-2. 1978
    ..for the in vivo rate of beta-galactosidase synthesis in mouse tissues to assess the mechanism by which the Bgs and Bgt loci regulate activity levels of this enzyme...
  42. ncbi Association between beta-galactosidase activities and coat color in mice
    I Seyedyazdani
    J Hered 64:295-6. 1973
  43. pmc Linkage of genetic determinants for mouse beta-galactosidase electrophoresis and activity
    G A Breen
    Genetics 85:73-84. 1977
    ..This structural gene, Bge, is closely linked (0/163 recombinants) with the Bgs site on chromosome 9 which regulates systemic levels of beta-galactosidase...
  44. ncbi Genetic determination of the beta-galactosidase developmental program in mouse liver
    K Paigen
    Cell 9:533-9. 1976
    ..The existence of a genetic variant with these properties is evidence that programmatic information capable of regulating the temporal expression of a structural gene can be encoded in DNA...
  45. ncbi Correlation between structural variation and activity of murine kidney beta-galactosidase: implications for genetic control
    I C Li
    Biochem Genet 14:933-52. 1976
    ..of the heat-sensitive A/HeJ beta-galactosidase to kidney tissue suggests that it is not determined by the Bgs locus, since the latter appears to be expressed in all tissues...
  46. ncbi Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression
    M Merchant
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4466
    Arch Biochem Biophys 298:389-94. 1992
    ..The results suggest that alpha NF and possibly MCDF compete with TCDD for cytosolic Ah receptor binding sites; however, MCDF may also inhibit the induction response by competing for and/or partially inactivating genomic binding sites...
  47. ncbi Linkage analysis of the Gi alpha 2 gene on mouse chromosome 9
    J De Maeyer-Guignard
    Institut Curie, CNRS URA 1343, Orsay, France
    Mamm Genome 3:601-3. 1992
  48. ncbi Linkage among esterase-6 (Es-6), neural cell adhesion molecule (NCAM), and apolipoprotein C-III (apoc-3) genes on rat chromosome 8
    E Kobayashi
    Imamichi Institute for Animal Reproduction, Ibaraki, Japan
    Mamm Genome 3:656-8. 1992
  49. ncbi Genes for epilepsy mapped in the mouse
    M L Rise
    Department of Biology, Boston College, Chestnut Hill 02167
    Science 253:669-73. 1991
    ..The location of El-1 on distal chromosome 9 may allow identification of an epilepsy candidate gene in humans on the basis of conserved synteny with human chromosome 3...
  50. ncbi Organization of the mouse acid beta-galactosidase gene
    E Nanba
    Department of Neurology, University of North Carolina School of Medicine, Chapel Hill 27599
    Biochem Biophys Res Commun 178:158-64. 1991
    ..Compared to the cDNA sequence from C57BL/6J mouse, there were five nucleotide polymorphisms in the protein-coding region, two of which resulted in altered amino acids...
  51. ncbi Linkage analysis of the murine Hyal-1 locus on chromosome 9
    J De Maeyer-Guignard
    CNRS URA 1343, Institut Curie Biologie, Centre Universitaire, Orsay, France
    J Exp Zool 258:246-8. 1991
    ..Linkage was tested to two anchor loci on chromosome 9: d (dilute, a coat color locus) and Bgl-s (a locus controlling beta-galactosidase activity)...
  52. ncbi Molecular cloning of mouse acid beta-galactosidase cDNA: sequence, expression of catalytic activity and comparison with the human enzyme
    E Nanba
    Department of Neurology, University of North Carolina School of Medicine, Chapel Hill 27599
    Biochem Biophys Res Commun 173:141-8. 1990
    ..All seven cysteine residues in the mouse enzyme are conserved in the human enzyme. Although the nucleotide sequence could be aligned to 60% identity with the E. coli beta-galactosidase, similarity in the amino acid sequence was minimal...
  53. ncbi Level of expression and chromosome mapping of the mouse cholecystokinin gene: implications for murine models of genetic obesity
    J M Friedman
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Genomics 5:463-9. 1989
    ....
  54. ncbi The structural genes encoding P450scc and P450arom are closely linked on mouse chromosome 9
    G L Youngblood
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0278
    Endocrinology 125:2784-6. 1989
    ..The information presented in this report, along with other studies, indicate conservation between homologous human and mouse chromosomal regions and suggest that human P450SCC will be found to be closely linked with human P450arom...
  55. pmc Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human
    C Blatt
    Weizmann Institute, Rehovoth, Israel
    Proc Natl Acad Sci U S A 85:7642-6. 1988
    ..These mapping assignments will be useful in defining the extent of the G alpha gene family and may help in attempts to correlate specific genetic diseases with genes corresponding to G proteins...
  56. ncbi Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9
    C E Hildebrand
    Biochem Biophys Res Commun 130:396-406. 1985
    ....
  57. ncbi Mendelian inheritance of variations in beta-galactosidase activities in the house mouse
    L G Lundin
    Biochem Genet 10:351-61. 1973
  58. ncbi Effects of the Bgs locus on mouse beta-galactosidase
    M H Meisler
    Biochem Genet 14:921-32. 1976
    The Bgs locus determines tissue levels of beta-galactosidase in the mouse, so that enzyme levels are twice as high in mice carrying the Bgsh allele as in mice carrying the Bgsd allele (Felton et al., 1974)...
  59. ncbi A locus determining beta-galactosidase activity in the mouse
    J Felton
    J Biol Chem 249:3267-72. 1974
  60. ncbi A gene affecting liver activities of three glycosidases in the house mouse
    E M Håkansson
    Biochem Genet 19:457-64. 1981
    ..The three enzyme activities are correlated with each other. The possible linkage between this gene and the Bgs locus on chromosome 9 is discussed.
  61. pmc Mapping of aminoacylase-1 and beta-galactosidase-A to homologous regions of human chromosome 3 and mouse chromosome 9 suggests location of additional genes
    S L Naylor
    Am J Hum Genet 34:235-44. 1982
    ..Since the mouse transferrin gene (Trf) is closely linked to the aminoacylase and beta-galactosidase loci, we predict that the human transferrin (TF) gene is on chromosome 3...
  62. ncbi Construction of a D2.B6-Fv-2r congenic mouse strain: nonlethality of the homozygous Fv-2' genotype
    M Dizik
    J Natl Cancer Inst 66:755-60. 1981
    ..B6-Fv-2r genome, as shown by the continued presence of C57BL/6 alleles at the flanking Kfo-1 and Bgl-s loci. The observed recombination frequency for the intervals between Fv-2 and Bgl-s was 6.8%.
  63. ncbi Assignment of a gene that determines erythrocytic guanosine-5'-triphosphate concentration (Gtpc) to mouse chromosome 9
    J P Jenuth
    Department of Paediatrics, Faculty of Medicine, University of Calgary, Canada
    Genome 37:399-404. 1994
    ..A test for linkage of Gtpc to transferrin (Trf) on chromosome 9 gave evidence of linkage with an observed recombination frequency of 14.6 +/- 5.5 and a 99% confidence interval of 3.9-33.9 cM...
  64. ncbi Effects of double amino-acid substitution polymorphism in acid beta-galactosidase gene in two inbred strains of mice
    Y Hara
    Department of Neurology, University of North Carolina School of Medicine, Chapel Hill 27599
    Biochim Biophys Acta 1217:49-53. 1994
    ..These results do not explain the significantly low acid beta-galactosidase activity in tissues of DBA mice, described earlier and also confirmed in this study...
  65. pmc Molecular heterogeneity of progenitors and radial migration in the developing cerebral cortex revealed by transgene expression
    E Soriano
    Institut National de la Sante et de la Recherche Medicale, Unité 106 Hôpital de la Salpêtrière, Paris, France
    Proc Natl Acad Sci U S A 92:11676-80. 1995
    ..Furthermore, the data show that neurons committed to the expression of the transgene migrate along very narrow, radial stripes...
  66. ncbi Report of the sixth international workshop on human chromosome 3 mapping 1995
    S L Naylor
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78284 7762, USA
    Cytogenet Cell Genet 72:255-70. 1996
  67. ncbi A defect in beta-galactosidase of B lymphocytes in the osteopetrotic (op/op) mouse
    N Yamamoto
    Laboratory of Cancer Immunology and Molecular Biology, Albert Einstein Cancer Center, Philadglphia, PA 19141, USA
    Immunol Lett 50:35-40. 1996
    ..The lyso-Pc-inducible beta-galactosidase activity of B lymphocytes was found to be defective in op/op mouse...
  68. ncbi Gene for a serum protein on chromosome 9 in the mouse
    E M Håkansson
    Genet Res 33:147-52. 1979
  69. ncbi Neurological manifestations of knockout mice with beta-galactosidase deficiency
    J Matsuda
    Department of Veterinary Science, National Institute of Health, Tokyo, Japan
    Brain Dev 19:19-20. 1997
    ..This is an authentic murine model of human GMI-gangliosidosis, and is useful for studies of its pathogenesis and treatment...
  70. ncbi Sequences 5' of the basement membrane laminin beta 1 chain gene (LAMB1) direct the expression of beta-galactosidase during development of the mouse testis and ovary
    C Li
    Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA
    Differentiation 62:129-37. 1997
    ....
  71. ncbi Endogenous nonecotropic proviruses mapped with oligonucleotide probes from the long terminal repeat region
    W N Frankel
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 5:275-81. 1994
    ..Together with proviruses identified previously with env probes, the LTR probe-reactive elements represent the majority of endogenous murine leukemia proviruses in the mouse genome...