beta catenin

Summary

Gene Symbol: beta catenin
Description: catenin (cadherin associated protein), beta 1
Alias: Bfc, Catnb, Mesc, catenin beta-1, beta-catenin
Species: mouse

Top Publications

  1. ncbi Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    Timothy F Day
    Geneti Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 8:739-50. 2005
  2. ncbi Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    V Brault
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:1253-64. 2001
  3. pmc Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    N Harada
    Banyu Tsukuba Research Institute Merck, Tsukuba 300 2611, Japan
    EMBO J 18:5931-42. 1999
  4. ncbi Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    J Behrens
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Science 280:596-9. 1998
  5. ncbi beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
    Dietmar Zechner
    Max Delbrück Center of Molecular Medicine, Robert Rossle Str 10, 13125, Berlin, Germany
    Dev Biol 258:406-18. 2003
  6. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
  7. pmc Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
    Chen Zhao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 12:528-41. 2007
  8. ncbi Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development
    Joo Seop Park
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 134:2533-9. 2007
  9. doi LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain
    Marta B Wisniewska
    International Institute of Molecular and Cell Biology, 02 109 Warsaw, Poland
    J Neurosci 30:4957-69. 2010
  10. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999

Research Grants

  1. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
  2. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2008
  3. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
  4. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
  5. Osteocyte control of bone formation via Sost
    TERESITA M BELLIDO; Fiscal Year: 2010
  6. Regulation of Hematopoietic Stem Cell Self-Renewal
    Tannishtha Reya; Fiscal Year: 2010
  7. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010
  8. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010
  9. Damage and regeneration in the hematopoietic system
    Tannishtha Reya; Fiscal Year: 2009
  10. Patterning of the optic vesicle by extrinsic factors
    Sabine Fuhrmann; Fiscal Year: 2003

Detail Information

Publications217 found, 100 shown here

  1. ncbi Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    Timothy F Day
    Geneti Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 8:739-50. 2005
    ..Controlling Wnt/beta-catenin signaling is a common molecular mechanism underlying chondrocyte and osteoblast differentiation and specification of intramembranous and endochondral ossification...
  2. ncbi Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    V Brault
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:1253-64. 2001
    ..Our results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development...
  3. pmc Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    N Harada
    Banyu Tsukuba Research Institute Merck, Tsukuba 300 2611, Japan
    EMBO J 18:5931-42. 1999
    ..Some nascent microadenomas were also found in the colon. These results present experimental genetic evidence that activation of the Wnt signaling pathway can cause intestinal and colonic tumors...
  4. ncbi Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    J Behrens
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Science 280:596-9. 1998
    ..Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation...
  5. ncbi beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
    Dietmar Zechner
    Max Delbrück Center of Molecular Medicine, Robert Rossle Str 10, 13125, Berlin, Germany
    Dev Biol 258:406-18. 2003
    ..beta-Catenin signals are thus essential for the maintenance of proliferation of neuronal progenitors, controlling the size of the progenitor pool, and impinging on the decision of neuronal progenitors to proliferate or to differentiate...
  6. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
    ..Our data demonstrate that beta-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm...
  7. pmc Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
    Chen Zhao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 12:528-41. 2007
    ..These studies demonstrate that Wnt signaling is required for the self-renewal of normal and neoplastic stem cells in the hematopoietic system...
  8. ncbi Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development
    Joo Seop Park
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 134:2533-9. 2007
    ..However, the failure of induced mesenchyme with high levels of beta-catenin activity to form epithelial structures suggests that modulating canonical signaling may be crucial for the cellular transition to the renal vesicle...
  9. doi LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain
    Marta B Wisniewska
    International Institute of Molecular and Cell Biology, 02 109 Warsaw, Poland
    J Neurosci 30:4957-69. 2010
    ..We propose that beta-catenin contributes to neuronal excitability not only by a local action at the synapse but also by activating gene expression in thalamic neurons...
  10. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
  11. pmc Wnt signaling regulates pancreatic beta cell proliferation
    Ingrid C Rulifson
    Department of Developmental Biology, Oncology Division, Stanford University, Stanford, CA 94305 5329, USA
    Proc Natl Acad Sci U S A 104:6247-52. 2007
    ..Thus, Wnt signaling is both necessary and sufficient for islet beta cell proliferation, and our study provides previously unrecognized evidence of a mechanism governing endocrine pancreas growth and function...
  12. pmc beta-catenin is a target for the ubiquitin-proteasome pathway
    H Aberle
    Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    EMBO J 16:3797-804. 1997
    ..We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin...
  13. ncbi Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
    Anjen Chenn
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 297:365-9. 2002
    ....
  14. pmc Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 17:2949-55. 2008
    ..The identification of beta-catenin as a key pro-ovarian and anti-testis signaling molecule will further our understanding of the mechanisms controlling sex determination and the molecular mechanisms that lead to sex-reversal...
  15. pmc Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
    Courtney M Karner
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nat Genet 41:793-9. 2009
    ..Wnt9b, signaling through the non-canonical Rho/Jnk branch of the Wnt pathway, is necessary for both of these processes...
  16. pmc Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression
    Peter Westenskow
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Development 136:2505-10. 2009
    ....
  17. pmc Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors
    Silvia Maretto
    Histology and Embryology Section, Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, 35131 Padua, Italy
    Proc Natl Acad Sci U S A 100:3299-304. 2003
    ..In summary, BAT-gal mice unveil the entire complexity of Wntbeta-catenin signaling in mammals and have broad application potentials for the identification of Wnt-responsive cell populations in development and disease...
  18. ncbi A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development...
  19. ncbi Beta-catenin signaling marks the prospective site of primitive streak formation in the mouse embryo
    Othman A Mohamed
    Department of Biology, McGill University Health Center, Royal Victoria Hospital, Montreal, QC, Canada
    Dev Dyn 231:416-24. 2004
    ....
  20. ncbi Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
    Mattias Backman
    Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, University of Oslo, The National Hospital, 0027 Oslo, Norway
    Dev Biol 279:155-68. 2005
    ..Thus, our data suggest that canonical Wnt signals are involved in maintaining the identity of the pallium by controlling expression of dorsal markers and by suppressing ventral programs from being activated in pallial progenitor cells...
  21. ncbi Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    Hongliang Hu
    Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
    Development 132:49-60. 2005
    ..Finally Wnt7b is identified as a potential endogenous ligand regulating osteogenesis. These data support a model that integrates Hh and Wnt signaling in the regulation of osteoblast development...
  22. ncbi Desmoplakin is essential in epidermal sheet formation
    V Vasioukhin
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Cell Biol 3:1076-85. 2001
    ..DP is therefore required for assembly of functional desmosomes, maintaining cytoskeletal architecture and reinforcing membrane attachments essential for stable intercellular adhesion...
  23. ncbi Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis
    Kameswaran Surendran
    Department of Pediatrics, Washington University School of Medicine, 5th Floor MPRB, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Am Soc Nephrol 16:2373-84. 2005
    ....
  24. ncbi Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing
    Sophia S Cheon
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Exp Cell Res 293:267-74. 2004
    ....
  25. ncbi Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
    Gregoire Jeannet
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Lausanne, Switzerland
    Blood 111:142-9. 2008
    ..These data provide the first evidence that hematopoietic cells can transduce canonical Wnt signals in the combined absence of beta- and gamma-catenin...
  26. pmc Beta-catenin is dispensable for hematopoiesis and lymphopoiesis
    Monica Cobas
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    J Exp Med 199:221-9. 2004
    ..In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis...
  27. ncbi Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells
    Yukinari Takao
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan
    Biochem Biophys Res Commun 353:699-705. 2007
    ..These results suggest that up-regulating Nanog through interaction with Oct-3/4 involves beta-catenin in the LIF- and Wnt-mediated maintenance of ES cell self-renewal...
  28. ncbi Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    Donald A Glass
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
    Dev Cell 8:751-64. 2005
    ....
  29. pmc Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination
    Shin Ichiro Hino
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Mol Cell Biol 25:9063-72. 2005
    ..These results indicate that PKA inhibits the ubiquitination of beta-catenin by phosphorylating beta-catenin, thereby causing beta-catenin to accumulate and the Wnt signaling pathway to be activated...
  30. pmc Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo
    Michael Buchert
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia
    PLoS Genet 6:e1000816. 2010
    ..Together, the present genotype-phenotype analysis suggests tissue-specific response levels for the Wnt/beta-catenin pathway that regulate both physiological and pathophysiological conditions...
  31. ncbi Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin
    A Cadoret
    Institut Cochin de Génétique Moléculaire INSERM U129, 75014 Paris, France
    Cancer Res 61:3245-9. 2001
    ..Thus, the key target genes of the beta-catenin signaling pathway in the liver remain to be identified...
  32. pmc Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver
    Xinping Tan
    Department of Pathology, University of Pittsburgh, School of Medicine, Pennsylvania 15261, USA
    Gastroenterology 129:285-302. 2005
    ..Wnt/beta-catenin activation is observed in normal liver development, regeneration, and liver cancer. Our aim was to elucidate the regulation and mechanism of this pathway in liver...
  33. ncbi Stabilization of beta-catenin impacts pancreas growth
    Patrick W Heiser
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 133:2023-32. 2006
    ..Taken together, these data suggest a previously unappreciated temporal/spatial role for beta-catenin signaling in the regulation of pancreas organ growth...
  34. pmc Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development
    Suresh K Ramasamy
    Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 307:237-47. 2007
    ..Thus, our results indicate that FGF10 plays a pivotal role in maintaining epithelial progenitor cell proliferation as well as coordinating alveolar smooth muscle cell formation and vascular development...
  35. pmc Beta-catenin interacts with MyoD and regulates its transcription activity
    Chang Hoon Kim
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th St, CB2803, Augusta, GA 30912, USA
    Mol Cell Biol 28:2941-51. 2008
    ..These results demonstrate that beta-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway...
  36. pmc beta-Catenin has sequential roles in the survival and specification of ventral dermis
    Jennifer Ohtola
    Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 135:2321-9. 2008
    ..Consistent with the different origins of dorsal and ventral dermal cells, our results demonstrate both conserved and divergent roles of beta-catenin/Wnt signaling in dermal development...
  37. pmc Lack of beta-catenin in early life induces abnormal glucose homeostasis in mice
    S Dabernat
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA
    Diabetologia 52:1608-17. 2009
    ..However, little is known about the involvement of beta-catenin in the endocrine or exocrine function of the mature pancreas. We report for the first time the impact of beta-catenin deletion in the pancreatic beta cells...
  38. pmc The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis
    Laura L Yates
    Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 19:2251-67. 2010
    ....
  39. pmc Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6
    Danielle Matsushima
    UNC Neuroscience Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 138:443-54. 2011
    ..Collectively, these results demonstrate that precise regulation of the ratio of SOX2 to PAX6 is necessary to ensure accurate progenitor cell specification, and place SOX2 as a decisive factor of neural competence in the retina...
  40. doi Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death
    Tamara Holowacz
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada
    Eur J Neurosci 33:1366-75. 2011
    ..These data reveal that β-catenin is not required for the maintenance or differentiation of NSCs, but is required for the adhesion and survival of neural progenitor cells...
  41. pmc A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition
    Sara Howard
    MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 6:e23899. 2011
    ..Lastly we present data suggesting that cadherins are required for augmented activation of the Wnt/β-catenin pathway in vivo. This suggests that cadherins play a crucial role in β-catenin-dependent transcription...
  42. pmc Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype
    Lorenza Ciani
    Departments of Medical Genetics and Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Mol Cell Biol 23:3575-82. 2003
    ..Our results confirm a necessary role for FAT1 in the modified adhesion junctions of the renal glomerular epithelial cell and reveal hitherto unsuspected roles for FAT1 in CNS development...
  43. pmc β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation
    I Ahmad
    The Beatson Institute for Cancer Research, Glasgow, Scotland, UK
    Oncogene 30:178-89. 2011
    ..Taken together these data show that deregulated Wnt signalling has a critical role in promoting UCC, and suggests that human UCC that have high levels of Wnt and PI3 kinase signalling may be responsive to mTOR inhibition...
  44. pmc The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties
    M Peifer
    Department of Biology, University of North Carolina, Chapel Hill 27599
    J Cell Biol 118:681-91. 1992
    ..The implications of these results for the structure and function of different cell-cell adhesive junctions are discussed...
  45. ncbi ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules
    Danette L Daniels
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 10:573-84. 2002
    ..The C-terminal armadillo repeats of beta-catenin may be an attractive target for compounds designed to disrupt aberrant beta-catenin-mediated transcription associated with various cancers...
  46. ncbi Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells
    Hye Youn Lee
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Science 303:1020-3. 2004
    ..Moreover, Wnt1 is able to instruct early NCSCs (eNCSCs) to adopt a sensory neuronal fate in a beta-catenin-dependent manner. Thus, the role of Wnt/beta-catenin in stem cells is cell-type dependent...
  47. ncbi Beta-catenin is essential for pancreatic acinar but not islet development
    L Charles Murtaugh
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 132:4663-74. 2005
    ..Thus, our data are consistent with a crucial role for canonical Wnt signals in acinar lineage specification and differentiation...
  48. pmc Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly
    Frauke Drees
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:903-15. 2005
    ..These results indicate a new role for alpha-catenin in local regulation of actin assembly and organization at sites of cadherin-mediated cell-cell adhesion...
  49. pmc COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis
    Masashi Okamura
    Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4 6 1, Komaba, Meguro ku, Tokyo 153 8904, Japan
    Proc Natl Acad Sci U S A 106:5819-24. 2009
    ..Our experiments define the COUP-TFII/SMRT complex as a previously unappreciated component of the linear pathway that directly links Wnt/beta-catenin signaling to repression of PPARgamma gene expression and the inhibition of adipogenesis...
  50. pmc Sall1-dependent signals affect Wnt signaling and ureter tip fate to initiate kidney development
    Susan M Kiefer
    John Cochran Veterans Affairs Medical Center, St Louis, MO 63106, USA
    Development 137:3099-106. 2010
    ..These studies indicate that Sall1-dependent signals from the metanephric mesenchyme are required to modulate ureteric bud tip Wnt patterning in order to initiate branching...
  51. pmc Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development
    Courtney M Karner
    Department of Internal Medicine Nephrology and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Dallas, TX 75390, USA
    Development 138:1247-57. 2011
    ..These findings provide novel insights into the molecular mechanisms that regulate progenitor cell differentiation during normal and pathological conditions...
  52. pmc beta-Catenin regulates excitatory postsynaptic strength at hippocampal synapses
    Takashi Okuda
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 104:13479-84. 2007
    ..Collectively, these findings suggest that the cadherin-beta-catenin complex is an integral component of synaptic strength regulation and plays a basic role in coupling synapse function and spine morphology...
  53. doi The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine
    Elsa Kress
    Universite de Lyon, Universite Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, INRA, CNRS, Institut de Génomique Fonctionnelle de Lyon, 69364 Lyon, France
    J Biol Chem 284:1234-41. 2009
    ..Moreover, we describe in this study a novel mechanism of action of sFRP2, responsible for the activation of beta-catenin signaling...
  54. ncbi Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region
    Markus Panhuysen
    Institute of Developmental Genetics, GSF Research Center for Environment and Health, 85764 Neuherberg, Germany
    Mol Cell Neurosci 26:101-11. 2004
    ..We suggest that Wnt1 acts as a regulator of proliferation of specific precursor populations in the developing mid-/hindbrain region and is only secondarily involved in maintenance of the mid-/hindbrain organizer...
  55. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
  56. ncbi Maternal beta-catenin and E-cadherin in mouse development
    Wilhelmine N de Vries
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Development 131:4435-45. 2004
    ..This developmental deficit is alleviated by the simultaneous absence of maternal E-cadherin, suggesting that E-cadherin regulates nuclear beta-catenin availability during embryonic genome activation...
  57. ncbi Beta-catenin-mediated cell-adhesion is vital for embryonic forebrain development
    Dirk Junghans
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    Dev Dyn 233:528-39. 2005
    ..In summary, we demonstrate that beta-catenin mediates cell-cell adhesion in the early telencephalon and is vital for maintaining the structural integrity of the neuroepithelium...
  58. pmc Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
    Lizhu Lin
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:9313-8. 2007
    ..Our findings demonstrate that beta-catenin signaling regulates proliferation and survival of cardiac progenitors...
  59. doi Defining the function of beta-catenin tyrosine phosphorylation in cadherin-mediated cell-cell adhesion
    Junji Tominaga
    Division of Cellular Interactions, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Genes Cells 13:67-77. 2008
    ..We also demonstrate that tyrosine phosphorylation of beta-catenin might regulate cadherin-mediated cell adhesion in a more complicated way than previously expected...
  60. pmc The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex
    Yukako Yokota
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Neuron 61:42-56. 2009
    ..Thus, APC is an essential regulator of radial glial polarity and is critical for the construction of cerebral cortex in mammals...
  61. pmc Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 24:1529-42. 2010
    ....
  62. pmc β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism
    Kevin F Kelly
    Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada
    Cell Stem Cell 8:214-27. 2011
    ..Collectively, our data suggest previously underappreciated, divergent TCF-dependent and TCF-independent roles for β-catenin in ESCs...
  63. pmc Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    Lilia Topol
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 162:899-908. 2003
    ..Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote beta-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation...
  64. ncbi alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion
    B Janssens
    Molecular Cell Biology Unit, Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology VIB Ghent University, B 9000 Ghent, Belgium
    J Cell Sci 114:3177-88. 2001
    ..We propose that alphaT-catenin is necessary for the formation of stretch-resistant cell-cell adhesion complexes, in particular, muscle cells...
  65. ncbi Defining the roles of beta-catenin and plakoglobin in cell-cell adhesion: isolation of beta-catenin/plakoglobin-deficient F9 cells
    Yoshitaka Fukunaga
    Division of Cellular Interactions, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Cell Struct Funct 30:25-34. 2005
    ..Moreover it was suggested that beta-catenin or plakoglobin is required not only for the cell adhesion activity but also for the stable expression and cell surface localization of E-cadherin...
  66. ncbi The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression
    Tohru Kimura
    Department of Pathology, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Dev Biol 300:545-53. 2006
    ..Our results show that the suppression of Wnt/beta-catenin signaling is a prerequisite for the normal development of PGCs...
  67. doi Canonical WNT/beta-catenin signaling is required for ureteric branching
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Dev Biol 317:83-94. 2008
    ..Together, these data demonstrate that beta-catenin performs essential functions during renal branching morphogenesis via control of a hierarchy of genes that control ureteric branching...
  68. doi Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction
    Pauliina M Munne
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Development 136:393-402. 2009
    ..Considering the role of mesenchyme in tooth induction and the design of tissue engineering protocols, our work may have uncovered how delicate control of tissue quantities alone influences the outcome between induction and inhibition...
  69. pmc Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons
    Mianzhi Tang
    VA Medical Center and Department of Pathology, University of California San Francisco, San Francisco, CA 94121, USA
    Development 136:2027-38. 2009
    ..They also suggest that beta-catenin-mediated signaling pathways can be targeted to promote and expand DA neurons in cell-based therapeutic strategies...
  70. pmc Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNA
    Rama Kamesh Bikkavilli
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 123:1352-62. 2010
    ..Thus, Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability...
  71. ncbi Expression and cell membrane localization of catenins during mouse preimplantation development
    M Ohsugi
    Max Planck Institut fur Immunbiologie, Freiburg, Federal Republic of Germany
    Dev Dyn 206:391-402. 1996
    ....
  72. pmc H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes
    J Espada
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, 28029 Madrid, Spain
    J Cell Biol 146:967-80. 1999
    ..These results indicate that H-Ras activation induces the relocalization and cytoplasmic stabilization of beta-catenin by a mechanism involving its interaction with PI3K...
  73. ncbi Biochemical interactions in the wnt pathway
    M J Seidensticker
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122, Berlin, Germany
    Biochim Biophys Acta 1495:168-82. 2000
    ..This review discusses the mechanisms that silence the pathway in cells that do not receive a wnt signal and goes on to describe the regulatory steps involved in the activation of the pathway...
  74. ncbi beta-Catenin is not required for proliferation and differentiation of epidermal mouse keratinocytes
    Horst Posthaus
    Institute of Animal Pathology, University of Bern, Länggassstr 122, 3012 Bern, Switzerland
    J Cell Sci 115:4587-95. 2002
    ..Taken together, our results demonstrate that epidermal proliferation and adhesion are independent of beta-catenin...
  75. ncbi Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation
    Brian Bierie
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 22:3875-87. 2003
    ..This suggests that the transdifferentiation into squamous metaplasias is an early response of endoderm-derived cells to beta-catenin, and that the development of intra-acinous hyperplasias or neoplastic foci is a later event...
  76. ncbi Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes
    Jibin Zhou
    Cardiovascular Research Institute, South Dakota Health Research Foundation, 1100 East 21st St, Suite 700, Sioux Falls, SD 57105, USA
    Am J Physiol Heart Circ Physiol 292:H270-6. 2007
    ..The results suggest that upregulation of gamma-catenin can compensate for the loss of beta-catenin in cardiomyocytes to maintain normal cardiac structure and function...
  77. ncbi Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling
    M Herzig
    Research Institute of Molecular Pathology, Vienna, Austria
    Oncogene 26:2290-8. 2007
    ..Together, the data indicate that signals other than beta-catenin/Tcf-mediated Wnt signaling are induced by the loss of E-cadherin during tumor progression in Rip1Tag2 transgenic mice...
  78. pmc beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells
    Michael J Nemeth
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892 4442, USA
    Stem Cells 27:1109-19. 2009
    ..From these data, we propose a model in which beta-catenin in the microenvironment is required noncell autonomously for long-term maintenance of hematopoietic progenitors...
  79. doi Beta-catenin-mediated signaling and cell adhesion in postgastrulation mouse embryos
    Andreas Hierholzer
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    Dev Dyn 239:191-9. 2010
    ..We found that beta-catenin is required for the correct localization of N-cadherin at the membrane of neural ectodermal cells and that its absence causes a disintegration of the neural tube...
  80. doi Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma
    Cassandra R Diegel
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49504, USA
    Cancer Res 70:9143-52. 2010
    ..Because rapamycin analogues are approved for treating other types of human malignancies, our findings suggest that rapamycin therapy should be evaluated for treating patients with salivary gland acinic cell carcinoma...
  81. pmc Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2
    Bo Gao
    National Human Genome Research Institute, Bethesda, MD 20892, USA
    Dev Cell 20:163-76. 2011
    ..Our studies have provided new insight to Robinow syndrome, Brachydactyly Type B1, and spinal bifida which are caused by mutations in human ROR2, WNT5A, or VANGL...
  82. pmc Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis
    I Ahmad
    Department of Uro Oncology, The Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland
    Cell Death Dis 2:e124. 2011
    ..Taken together these data definitively show Ras pathway activation strongly cooperates with Wnt signalling to drive UCC in vivo...
  83. pmc Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias
    Keiko Miyoshi
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:219-24. 2002
    ..These data demonstrate that the activation of beta-catenin signaling induces a program that results in loss of mammary epithelial cell differentiation and induction of epidermal structures...
  84. pmc Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148
    Maria Grazia Lampugnani
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    J Cell Biol 161:793-804. 2003
    ..In sparse cells or in VE-cadherin-null cells, this phenomenon cannot occur and the receptor is fully activated by the growth factor...
  85. pmc The role of Axin2 in calvarial morphogenesis and craniosynostosis
    Hsiao Man Ivy Yu
    Center for Oral Biology, Department of Biomedical Genetics, Abs Institute of Biomedical Sciences, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Development 132:1995-2005. 2005
    ..The craniofacial anomalies caused by the Axin2 mutation are mediated through activation of beta-catenin signaling, suggesting a novel role for the Wnt pathway in skull morphogenesis...
  86. doi Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex
    Atsushi Kuwahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 137:1035-44. 2010
    ..These results reveal that Wnt signaling via N-myc is crucial for the control of neuron number in the developing neocortex...
  87. ncbi The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
    L Zeng
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 90:181-92. 1997
    ..Thus, Axin is a novel inhibitor of Wnt signaling and regulates an early step in embryonic axis formation in mammals and amphibians...
  88. pmc Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein
    K Tago
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113, Japan
    Genes Dev 14:1741-9. 2000
    ..These results suggest that ICAT negatively regulates Wnt signaling via inhibition of the interaction between beta-catenin and TCF and is integral in development and cell proliferation...
  89. ncbi Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar
    Johanna Laurikkala
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Development 129:2541-53. 2002
    ..In conclusion, we suggest that Eda and Edar are associated with the onset of ectodermal patterning and that ectodysplasin/edar signaling also regulates the morphogenesis of hair follicles...
  90. pmc A developmental conundrum: a stabilized form of beta-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells
    Ramanuj DasGupta
    Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Cell Biol 158:331-44. 2002
    ..Finally, by varying the level of beta-catenin signaling during a cell fate program, the skin cell appears to be pliable, switching fates multiple times...
  91. ncbi Deletion of beta-catenin impairs T cell development
    Youyuan Xu
    Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1177-82. 2003
    ..In addition, beta-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T cells. These data indicate that beta-catenin-mediated signals are required for normal T cell development...
  92. ncbi The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate
    Teresa H Chae
    Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center and Department of Neurology and Program in Neuroscience, Harvard Medical School, HIM 816, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    Nat Genet 36:264-70. 2004
    ..Apical localization of the SNARE Vamp7 is also disrupted. Thus, alpha Snap is essential for apical protein localization and cell fate determination in neuroepithelial cells...
  93. pmc Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas
    S Colnot
    Institut Cochin, Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104, Universite Paris V, 24 rue du Faubourg St Jacques, 75014 Paris, France
    Proc Natl Acad Sci U S A 101:17216-21. 2004
    ..Thus, deletion of Apc in the liver provides a valuable model of human HCC, and, in this model, activation of the Wnt/beta-catenin pathway by invalidation of Apc is required for liver tumorigenesis...
  94. ncbi The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis
    Ugo Borello
    Stem Cell Research Institute, DIBIT, H San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Development 133:3723-32. 2006
    ..Taken together, these results demonstrate that Myf5 is a direct target of Wnt/beta-catenin, and that its full activation requires a cooperative interaction between the canonical Wnt and the Shh/Gli pathways in muscle progenitor cells...
  95. pmc Spontaneous repopulation of β-catenin null livers with β-catenin-positive hepatocytes after chronic murine liver injury
    Michael D Thompson
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 54:1333-43. 2011
    ..A few β-catenin-positive cholangiocytes were observed albeit only after long-term DDC exposure and trailed the appearance of β-catenin-positive hepatocytes...
  96. ncbi Lack of beta-catenin affects mouse development at gastrulation
    H Haegel
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Development 121:3529-37. 1995
    ..Our results demonstrate that, although beta-catenin is expressed rather ubiquitously, it is specifically required in the ectodermal cell layer...
  97. pmc Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex
    R M Kypta
    Department of Physiology, University of California, San Francisco 94143 0724, USA
    J Cell Biol 134:1519-29. 1996
    ..We propose that changes in tyrosine phosphorylation of beta-catenin mediated by TrkA and LAR-PTPs control cadherin adhesive function during processes such as neurite outgrowth...
  98. ncbi Nuclear localization of beta-catenin by interaction with transcription factor LEF-1
    O Huber
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Freiburg, Germany
    Mech Dev 59:3-10. 1996
    ..As shown for beta-catenin, ectopic expression of LEF-1 in Xenopus embryos caused duplication of the body axis, indicating a regulatory role for a LEF-1-like molecule in dorsal mesoderm formation...
  99. ncbi A specific domain in alpha-catenin mediates binding to beta-catenin or plakoglobin
    O Huber
    Max Planck Institute for Immunobiology, Freiburg, Germany
    J Cell Sci 110:1759-65. 1997
    ..The results described here, together with our previous work, give strong support for the idea that these proteins associate by hydrophobic interactions of two alpha-helices...
  100. ncbi Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription
    F J Staal
    Department of Immunology and Center for Biomedical Genetics, Utrecht Medical Center, Utrecht, The Netherlands
    Eur J Immunol 31:285-93. 2001
    ..Retroviral expression of soluble Wnt receptor mutants that block Wnt signaling inhibits thymocyte development. These results imply an important role for the Wnt cascade in thymocyte development...
  101. ncbi The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin
    A H Huber
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 105:391-402. 2001
    ..APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly...

Research Grants25

  1. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..abstract_text> ..
  2. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2008
    ..abstract_text> ..
  3. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  4. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  5. Osteocyte control of bone formation via Sost
    TERESITA M BELLIDO; Fiscal Year: 2010
    ..We expect that this work will provide opportunities for the development of novel therapeutic approaches leading to bone anabolism through actions on osteocytes. ..
  6. Regulation of Hematopoietic Stem Cell Self-Renewal
    Tannishtha Reya; Fiscal Year: 2010
    ..abstract_text> ..
  7. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010
    ....
  8. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010
    ..Additionally, this information should allow us to coax embryonic stem cells into becoming important transplantable derivatives of endoderm, such as insulin-producing beta cells to treat patients with Type 1 diabetes. ..
  9. Damage and regeneration in the hematopoietic system
    Tannishtha Reya; Fiscal Year: 2009
    ..Furthermore, understanding the basis of impaired regeneration in the aging hematopoietic system may allow us to design novel means to improve the health and quality of life of aging patients. ..
  10. Patterning of the optic vesicle by extrinsic factors
    Sabine Fuhrmann; Fiscal Year: 2003
    ..Subsequently, the identified molecule will be cloned and tested for the RPE-promoting activity in explant cultures and by transfection of chick embryos. ..
  11. WNT signals in developing and postnatal teeth
    Sarah Millar; Fiscal Year: 2008
    ..These experiments will help to place WNT signals in the network of regulatory factors that control tooth development, and will test the potential use of WNT activation in strategies for tooth or enamel regeneration. ..
  12. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2008
    ..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
  13. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  14. Cancer Center Tumor Phenotyping Core
    Gregory Boivin; Fiscal Year: 2006
    ..Expansion of personnel and availability of supply dollars will allow this core to serve numerous investigators in the cancer community. ..
  15. THE ROLE OF SRF IN CARDIAC FUNCTION AND DEVELOPMENT
    RAVINDRA MISRA; Fiscal Year: 2005
    ..These studies will both elucidate the mechanisms by which SRF functions in heart and will establish powerful new methodologies for studying heart formation and function. ..
  16. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  17. beta-Catenin/NF-kappaBeta and Colon Cancer
    Shahid Umar; Fiscal Year: 2004
    ..By studying a mechanistic basis of NF-kappaB and beta-catenin mediated increases in cell census, in the absence and presence of chronic inflammation, we may identify new treatment strategies for reducing cancer risk. ..
  18. Is non-canonical Wnt signaling required in cardiac neural crest cells?
    Ethan David Cohen; Fiscal Year: 2008
    ..This.information may lead to new detection or treatment strategies. [unreadable] [unreadable] [unreadable]..
  19. Transcriptional Control of Early Coronary Vascular Development
    RAVINDRA P MISRA; Fiscal Year: 2010
    ....
  20. WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTH
    Sarah E Millar; Fiscal Year: 2010
    ..abstract_text> ..
  21. Epithelial Cell Structure in Vertebrate Development
    Jeffrey D Hildebrand; Fiscal Year: 2010
    ..We will continue to use in vivo studies in mice and in vitro studies in cell culture to understand the molecular mechanisms underlying human birth defects. ..
  22. Regulation and Function of MAPKAP Kinases
    Thomas Sturgill; Fiscal Year: 2005
    ..Aim four is to characterize the activation, enzymatic properties, and functions of MAPKAP kinase-like enzymes (Rcklp, Rck2p) in yeast, a model eukaryote, using combined biochemical and genetic approaches. ..
  23. mTOR Signaling Pathways
    Thomas W Sturgill; Fiscal Year: 2010
    ..We will investigate novel candidate mTOR-interacting proteins identified by MS. Finally, to understand better the mechanisms involved in mTORC2, we propose to identify pianissimo-interacting proteins. ..
  24. Inactivation of the Muc2 gene and colorectal cancer
    Anna Velcich; Fiscal Year: 2005
    ....
  25. Colon Cell Differentiation: NAB and MUC2 Gene Expression
    Anna Velcich; Fiscal Year: 2009
    ..5. Finally, we will extend our use of microarray technology to determine how NaB perturbs profiles of gene expression that define lineage specific differentiation (Velcich et al., submitted). ..