Bdnf

Summary

Gene Symbol: Bdnf
Description: brain derived neurotrophic factor
Alias: brain-derived neurotrophic factor
Species: mouse

Top Publications

  1. pmc Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex
    Kazuko Sakata
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892 3714, USA
    Proc Natl Acad Sci U S A 106:5942-7. 2009
  2. pmc Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
    W E Lyons
    Neural Development Group, Advanced BioScience Laboratories Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 96:15239-44. 1999
  3. pmc BDNF regulates eating behavior and locomotor activity in mice
    S G Kernie
    Center for Developmental Biology, U T Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75235 9133, USA
    EMBO J 19:1290-300. 2000
  4. ncbi Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
    M Rios
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Mol Endocrinol 15:1748-57. 2001
  5. ncbi DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
    Keri Martinowich
    Neuroscience Interdepartmental Program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA
    Science 302:890-3. 2003
  6. pmc Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain
    M Hofer
    Max Planck Institute for Psychiatry, Department of Neurochemistry, Martinsried, FRG
    EMBO J 9:2459-64. 1990
  7. pmc A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
    Sung Wuk Jang
    Department of Pathology, Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:2687-92. 2010
  8. doi Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth
    Stefanie Rauskolb
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Neurosci 30:1739-49. 2010
  9. ncbi Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior
    Sabine Chourbaji
    Central Institut of Mental Health Mannheim CIMA, University of Heidelberg, Mannheim J 5 D 68159, Germany
    Brain Res Mol Brain Res 121:28-36. 2004
  10. ncbi Control of hyperphagia prevents obesity in BDNF heterozygous mice
    Vincenzo Coppola
    Neural Development Group, Mouse Cancer Genetics Program, National Cancer Institute, 7th Street, Bldg 560 Rm 32 31D, P O Box B, Frederick, MD 21702, USA
    Neuroreport 15:2665-8. 2004

Detail Information

Publications177 found, 100 shown here

  1. pmc Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex
    Kazuko Sakata
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892 3714, USA
    Proc Natl Acad Sci U S A 106:5942-7. 2009
    Transcription of Bdnf is controlled by multiple promoters, which drive expression of multiple transcripts encoding for the same protein...
  2. pmc Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
    W E Lyons
    Neural Development Group, Advanced BioScience Laboratories Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 96:15239-44. 1999
    Brain-derived neurotrophic factor (BDNF) has trophic effects on serotonergic (5-HT) neurons in the central nervous system...
  3. pmc BDNF regulates eating behavior and locomotor activity in mice
    S G Kernie
    Center for Developmental Biology, U T Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75235 9133, USA
    EMBO J 19:1290-300. 2000
    Brain-derived neurotrophic factor (BDNF) was studied initially for its role in sensory neuron development...
  4. ncbi Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
    M Rios
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Mol Endocrinol 15:1748-57. 2001
    ..Our results demonstrate that brain derived neurotrophic factor has an essential maintenance function in the regulation of anxiety-related behavior and in food ..
  5. ncbi DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
    Keri Martinowich
    Neuroscience Interdepartmental Program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA
    Science 302:890-3. 2003
    ..We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the ..
  6. pmc Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain
    M Hofer
    Max Planck Institute for Psychiatry, Department of Neurochemistry, Martinsried, FRG
    EMBO J 9:2459-64. 1990
    Brain-derived neurotrophic factor (BDNF) is a protein that allows the survival of specific neuronal populations...
  7. pmc A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
    Sung Wuk Jang
    Department of Pathology, Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:2687-92. 2010
    Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis...
  8. doi Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth
    Stefanie Rauskolb
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Neurosci 30:1739-49. 2010
    Although brain-derived neurotrophic factor (BDNF) is linked with an increasing number of conditions causing brain dysfunction, its role in the postnatal CNS has remained difficult to assess...
  9. ncbi Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior
    Sabine Chourbaji
    Central Institut of Mental Health Mannheim CIMA, University of Heidelberg, Mannheim J 5 D 68159, Germany
    Brain Res Mol Brain Res 121:28-36. 2004
    ..disorders in humans coincide with a decreased activity and/or expression of brain-derived neurotrophic factor (BDNF) in the brain...
  10. ncbi Control of hyperphagia prevents obesity in BDNF heterozygous mice
    Vincenzo Coppola
    Neural Development Group, Mouse Cancer Genetics Program, National Cancer Institute, 7th Street, Bldg 560 Rm 32 31D, P O Box B, Frederick, MD 21702, USA
    Neuroreport 15:2665-8. 2004
    Reduced levels of BDNF in mice cause obesity and behavioral abnormalities including increased aggression and hyperactivity...
  11. pmc Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes
    Matteo Bergami
    Department of Human and General Physiology, University of Bologna, I 40126 Bologna, Italy
    J Cell Biol 183:213-21. 2008
    Activity-dependent secretion of brain-derived neurotrophic factor (BDNF) is thought to enhance synaptic plasticity, but the mechanisms controlling extracellular availability and clearance of secreted BDNF are poorly understood...
  12. doi Involvement of brain-derived neurotrophic factor (BDNF) in MP4-induced autoimmune encephalomyelitis
    Sita Javeri
    Department of Anatomy, University of Cologne, Joseph Stelzmann Str 9, 50931 Cologne, Germany
    Clin Immunol 137:181-9. 2010
    The role of brain-derived neurotrophic factor (BDNF) in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) is still unclear...
  13. ncbi Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites
    Jessica A Gorski
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 23:6856-65. 2003
    Brain-derived neurotrophic factor (BDNF) is thought to be involved in neuronal survival, migration, morphological and biochemical differentiation, and modulation of synaptic function in the CNS...
  14. ncbi Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
    Petti T Pang
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
    Science 306:487-91. 2004
    ..Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear...
  15. ncbi Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus
    Mikko Sairanen
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 25:1089-94. 2005
    ..increase proliferation of neuronal progenitor cells and expression of brain-derived neurotrophic factor (BDNF) in the hippocampus...
  16. ncbi Mice lacking brain-derived neurotrophic factor develop with sensory deficits
    P Ernfors
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
    Nature 368:147-50. 1994
    ..Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, can prevent the death of particular peripheral sensory neurons in vitro, and ..
  17. pmc Localization of brain-derived neurotrophic factor to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cells
    Steve C Danzer
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:11346-55. 2004
    ..This mossy fiber pathway contains the highest concentration of brain-derived neurotrophic factor (BDNF) in the CNS, yet whether BDNF is positioned to regulate the excitatory and/or inhibitory pathways is unknown...
  18. ncbi Expression of brain-derived neurotrophic factor and TrkB neurotrophin receptors after striatal injury in the mouse
    J Y Wong
    Department of Neurology, University of Melbourne, Austin, Australia
    Exp Neurol 148:83-91. 1997
    Brain-derived neurotrophic factor (BDNF) promotes the survival and differentiation of nigral dopaminergic neurons and supports the activity of dopaminergic cells grafted into the striatum...
  19. pmc Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination
    Kevin G Bath
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Neurosci 28:2383-93. 2008
    Neurogenesis, the division, migration, and differentiation of new neurons, occurs throughout life. Brain derived neurotrophic factor (BDNF) has been identified as a potential signaling molecule regulating neurogenesis in the ..
  20. pmc Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear
    Dennis C Choi
    Department of Psychiatry and Behavioral Sciences, Howard Hughes Medical Institute, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:2675-80. 2010
    ..deletion, and pharmacological rescue with a TrkB agonist, we examined the role of a primary candidate mechanism, BDNF, in conditioned fear...
  21. doi BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse
    Verna Louhivuori
    Department of Biomedicine Physiology, University of Helsinki, PO Box 63, FIN 00014 Helsinki, Finland
    Neurobiol Dis 41:469-80. 2011
    ..Brain-derived neurotrophic factor (BDNF) and its TrkB receptors play a central role in neuronal maturation and plasticity...
  22. doi Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice
    Zhi Qiang Xu
    Department of Human Physiology, Flinders University, Adelaide, SA 5001, Australia
    Eur J Neurosci 33:1376-84. 2011
    ..Migration of cerebellar granule cells (CGCs) requires multiple factors. Mature brain-derived neurotrophic factor (BDNF) positively regulates the proliferation, migration, survival and differentiation of CGCs in rodents...
  23. pmc Mouse and rat BDNF gene structure and expression revisited
    Tamara Aid
    Department of Gene Technology, Tallinn University of Technology, Tallinn, Estonia
    J Neurosci Res 85:525-35. 2007
    Brain-derived neurotrophic factor (BDNF) has important functions in the development of the nervous system and in brain plasticity-related processes such as memory, learning, and drug addiction...
  24. pmc Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
    S A Heldt
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Mol Psychiatry 12:656-70. 2007
    Brain-derived neurotrophic factor (BDNF) is known to play a critical role in the synaptic plasticity underlying the acquisition and/or consolidation of certain forms of memory...
  25. ncbi Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain
    Jing Zhao
    Molecular Nociception Group, Department of Biology, University College London, London WC1E 6BT, UK
    Mol Cell Neurosci 31:539-48. 2006
    ..Here, we used the Cre-loxP system to delete BDNF in most nociceptive sensory neurons. Conditional null animals were healthy with no sensory neuron loss...
  26. ncbi Heterozygous knock-out mice for brain-derived neurotrophic factor show a pathway-specific impairment of long-term potentiation but normal critical period for monocular deprivation
    Alessandro Bartoletti
    Scuola Normale Superiore, Laboratorio di Neurobiologia, 56100 Pisa, Italy
    J Neurosci 22:10072-7. 2002
    Genetic deletion of a single allele of the BDNF gene affects hippocampal LTP and causes several behavioral phenotypes, including deficits in spatial learning...
  27. pmc Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release
    Linda Lin Yan Wu
    Department of Human Physiology and Centre for Neuroscience, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia
    J Biol Chem 285:5614-23. 2010
    Brain-derived neurotrophic factor (BDNF) plays a pivotal role in brain development and synaptic plasticity...
  28. ncbi The role of neurotrophin receptors in female germ-cell survival in mouse and human
    Norah Spears
    Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 130:5481-91. 2003
    ..showed that mRNA encoding TrkB and its two ligands, neurotrophin 4 (NT4) and brain-derived neurotrophic factor (BDNF), were present throughout the period of follicle formation in the mouse...
  29. ncbi Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood
    C Glorioso
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15261, USA
    Mol Psychiatry 11:633-48. 2006
    Brain-derived neurotrophic factor (BDNF) has been reported to be critical for the development of cortical inhibitory neurons...
  30. ncbi Differential expression of BDNF mRNA splice variants in mouse brain and immune cells
    Niels Kruse
    Institute for Multiple Sclerosis Research, Medical Faculty of University of Göttingen and Gemeinnützige Hertie Stiftung, Waldweg 33, 37073 Gottingen, Germany
    J Neuroimmunol 182:13-21. 2007
    For the neurotrophin BDNF several splice variants were recently described. We analyzed the expression of mBDNF mRNA splice variants in cells of the immune system in comparison to the central nervous system (CNS)...
  31. ncbi Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse
    Danielle L Graham
    Department of Psychiatry, The Seay Center for Basic and Applied Research in Psychiatric Illness, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Nat Neurosci 10:1029-37. 2007
    ..intravenous cocaine self-administration in rats induced a transient increase in brain-derived neurotrophic factor (BDNF) and activation of TrkB-mediated signaling in the nucleus accumbens (NAc)...
  32. doi Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
    Tomoya Matsumoto
    Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Nat Neurosci 11:131-3. 2008
    Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival...
  33. pmc Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity
    Bernd Fritzsch
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e9377. 2010
    ..The homeobox gene Prox1 is required for lens, retina, pancreas, liver, and lymphatic vasculature development and is expressed in inner ear supporting cells and neurons...
  34. doi Hippocampal enlargement in Bassoon-mutant mice is associated with enhanced neurogenesis, reduced apoptosis, and abnormal BDNF levels
    Alexandra Heyden
    Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Cell Tissue Res 346:11-26. 2011
    ..and of other forebrain structures was accompanied by increased levels of brain-derived neurotrophic factor (BDNF)...
  35. pmc Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo
    Luxiang Cao
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Curr Biol 17:911-21. 2007
    ..However, the molecular pathways that modulate axonal-branch stability or formation in competitive environments remain unknown...
  36. ncbi Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor
    Zachary C Baquet
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 24:4250-8. 2004
    Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, modulates neuronal survival, differentiation, and synaptic function...
  37. ncbi Brain-derived neurotrophic factor regulates the maturation of layer 4 fast-spiking cells after the second postnatal week in the developing barrel cortex
    Chiaki Itami
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, Tokyo 187 8502, Japan
    J Neurosci 27:2241-52. 2007
    Brain-derived neurotrophic factor (BDNF) has been reported to play a critical role in modulating plasticity in developing sensory cortices...
  38. doi Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice
    M S Zajac
    Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne, Parkville, Vic, Australia
    Hippocampus 20:621-36. 2010
    Brain-derived neurotrophic factor (BDNF) is an essential neurotrophin and regulation of its expression is complex due to multiple 5' untranslated exons which are separately spliced to a common coding exon to form unique mRNA transcripts...
  39. ncbi A changing pattern of brain-derived neurotrophic factor expression correlates with the rearrangement of fibers during cochlear development of rats and mice
    B Wiechers
    Department of Oto Rhino Laryngology, University of Tubingen, D 72076 Tubingen, Germany
    J Neurosci 19:3033-42. 1999
    ..We observed a spatiotemporal change in the localization of brain-derived neurotrophic factor (BDNF) protein and mRNA, which correlated with the reorganization of fibers...
  40. ncbi Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities
    G Fan
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 3:350-7. 2000
    To directly compare biological activities of the neurotrophins NT4 and BDNF in vivo, we replaced the BDNF coding sequence with the NT4 sequence in mice (Bdnfnt4-ki)...
  41. ncbi Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses
    Stanislav S Zakharenko
    Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Neuron 39:975-90. 2003
    Brain-derived neurotrophic factor (BDNF) has been implicated in several forms of long-term potentiation (LTP) at different hippocampal synapses...
  42. pmc Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway
    Zhe Yu Chen
    Department of Psychiatry, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:6156-66. 2005
    Brain-derived neurotrophic factor (BDNF), after activity-dependent secretion from neurons, modulates critical nervous system functions...
  43. ncbi Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family
    P Ernfors
    Department of Medical Chemistry, Karolinska Institute, Stockholm, Sweden
    Neuron 5:511-26. 1990
    Cells expressing mRNA for hippocampus-derived neurotrophic factor (HDNF/NT-3) or brain-derived neurotrophic factor (BDNF) were identified by in situ hybridization...
  44. ncbi Sensory but not motor neuron deficits in mice lacking NT4 and BDNF
    X Liu
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
    Nature 375:238-41. 1995
    ..Neurotrophin-4 (NT4), alone or in combination with brain-derived neurotrophic factor (BDNF), has been suggested to be necessary for the survival of peripheral sensory neurons and central nervous system (CNS)..
  45. ncbi Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice
    L M Bianchi
    Regeneron Pharmaceuticals Inc, Tarrytown, NY 10591, USA
    Development 122:1965-73. 1996
    ..among developing cochlear or vestibular neurons for available amounts of either brain-derived neurotrophic factor (BDNF) or neurotrophin-4/5 (NT-4/5). Both cochlear and vestibular neurons were present in mice lacking NT-4/5...
  46. ncbi Synaptic innervation density is regulated by neuron-derived BDNF
    C G Causing
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Canada
    Neuron 18:257-67. 1997
    In this report, we have examined the role of neuron-derived BDNF at an accessible synapse, that of preganglionic neurons onto their sympathetic neuron targets...
  47. pmc The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
    S X Bamji
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Cell Biol 140:911-23. 1998
    ..survival is maintained with low quantities of NGF or KCl, the neurotrophin brain-derived neurotrophic factor (BDNF), which does not activate Trk receptors on sympathetic neurons, causes neuronal apoptosis and increased ..
  48. ncbi FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis
    U Pirvola
    Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 20:6125-34. 2000
    ..Our findings provide genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear...
  49. pmc NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development
    W Y Kim
    Department of Molecular Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Development 128:417-26. 2001
    ....
  50. pmc BDNF but not NT-4 is required for normal flexion reflex plasticity and function
    P A Heppenstall
    Growth Factors and Regeneration Group, Department of Neuroscience, Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
    Proc Natl Acad Sci U S A 98:8107-12. 2001
    ..Brain-derived neurotrophic factor (BDNF) might be released by nociceptors onto spinal neurons and mediate central sensitization associated with chronic ..
  51. pmc Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression
    I Farinas
    Program in Neuroscience, Department of Physiology and Howard Hughes Medical Institute, University of California, San Francisco, California 94143 0724, USA
    J Neurosci 21:6170-80. 2001
    ..of the deficit in the NT-3 mutant to the spatial-temporal expression patterns of brain-derived neurotrophic factor (BDNF) and NT-3, using lacZ reporters in each gene and with expression of the specific neurotrophin receptors, trkB and ..
  52. ncbi Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice
    J A Gorski
    Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Neuroscience 121:341-54. 2003
    Brain-derived neurotrophic factor (BDNF) participates in synaptic plasticity and the adaptive changes in the strength of communication between neurons thought to underlie aspects of behavioral adaptation...
  53. ncbi Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:372-83. 2005
    ..We investigated the involvement of signaling mediated by brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB in producing the altered GABA-related gene expression in schizophrenia...
  54. ncbi REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis
    Nurit Ballas
    Howard Hughes Medical Institute, Dept of Neurology and Behavior, The State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Cell 121:645-57. 2005
    ..Thus, a multistage repressor mechanism controls the orderly expression of genes during development while still permitting fine tuning in response to specific stimuli...
  55. ncbi Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease
    Jose R Pineda
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Spain
    J Neurochem 93:1057-68. 2005
    ..Here, we study the role of brain-derived neurotrophic factor (BDNF) in alterations of the nigrostriatal system associated with transgenics carrying mutant huntingtin...
  56. pmc Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit
    V Matei
    Department of Biomedical Science, Creighton University, Omaha, Nebraska 68178, USA
    Dev Dyn 234:633-50. 2005
    ..Neurog 1 null mice show a truncation of clonal expansion of hair cell precursors through temporally altered terminal mitosis, thereby resulting in smaller sensory epithelia...
  57. pmc A disorganized innervation of the inner ear persists in the absence of ErbB2
    Jacqueline K Morris
    Department of Biology and Geology, Baldwin Wallace College, Berea, OH 44017, USA
    Brain Res 1091:186-99. 2006
    ..null mice retain afferents to inner hair cells possibly because of the prominent expression of the neurotrophin Bdnf in developing hair cells...
  58. ncbi Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice
    Haibo Sha
    Model Animal Research Center, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
    Physiol Genomics 31:252-63. 2007
    Mutants of brain-derived neurotrophic factor (BDNF) are associated with obesity. However, the regulatory mechanism of BDNF expression is still unclear...
  59. doi Genetic increase in brain-derived neurotrophic factor levels enhances learning and memory
    Yukako Nakajo
    Laboratory for Cerebrovascular Disorders, Research Institute of National Cardio Vascular Center, Suita, Osaka 565 8565, Japan
    Brain Res 1241:103-9. 2008
    Brain-derived neurotrophic factor (BDNF), a neurotrophin, is known to promote neuronal differentiation stimulating neurite outgrowth in the developing CNS, and is also known to modulate synaptic plasticity, thereby contributing to ..
  60. pmc Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor
    M Korte
    Max Planck Institut fur Psychiatrie, Munich Martinsried, Germany
    Proc Natl Acad Sci U S A 92:8856-60. 1995
    Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor (NGF) gene family, has been shown to influence the survival and differentiation of specific classes of neurons in vitro and in vivo...
  61. ncbi Complementary roles of BDNF and NT-3 in vestibular and auditory development
    P Ernfors
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
    Neuron 14:1153-64. 1995
    The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene...
  62. ncbi Suppressed epileptogenesis in BDNF mutant mice
    M Kokaia
    Department of Neurology, University Hospital, Lund, Sweden
    Exp Neurol 133:215-24. 1995
    ..kindling epileptogenesis causes a marked, transient increase of the synthesis of brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons...
  63. pmc Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
    K R Jones
    Howard Hughes Medical Institute University of California, San Francisco School of Medicine 94143
    Cell 76:989-99. 1994
    Brain-derived neurotrophic factor (BDNF), a neurotrophin, enhances the survival and differentiation of several classes of neurons in vitro. To determine its essential functions, we have mutated the BDNF gene...
  64. ncbi Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice
    D J Liebl
    Developmental Biology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9133, USA
    J Neurosci 17:9113-21. 1997
    ..We have analyzed embryonic and neonatal mice with mutations in the BDNF, neurotrophin 3 (NT-3), and TrkC genes...
  65. ncbi Learning deficit in BDNF mutant mice
    S Linnarsson
    Department of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden
    Eur J Neurosci 9:2581-7. 1997
    Brain-derived neurotrophic factor (BDNF) has been implicated in the regulation of high-frequency synaptic transmission and long-term potentiation in the hippocampus, processes that are also thought to be involved in the learning of ..
  66. ncbi Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors
    C L Stucky
    Department of Neurology, University of Wurzburg, D 97080 Wurzburg, Germany
    J Neurosci 18:7040-6. 1998
    ..Previous studies have shown that BDNF is required for the mechanical sensitivity of slowly adapting (SA) mechanoreceptors but not for the postnatal ..
  67. ncbi BDNF overexpression induces differential increases among subsets of sympathetic innervation in murine back skin
    V A Botchkarev
    Department of Dermatology, Charite, Humboldt University Berlin, Germany
    Eur J Neurosci 10:3276-83. 1998
    ..investigated the sympathetic innervation of back skin in mice overexpressing brain-derived neurotrophic factor (BDNF) under the alpha-myosin heavy-chain promoter, as well as in BDNF knockout (-/-) mice...
  68. ncbi Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice
    L D Pozzo-Miller
    Laboratory of Neurobiology, National Institute of Neurological Diseases and Stroke NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 19:4972-83. 1999
    Brain-derived neurotrophic factor (BDNF) promotes long-term potentiation (LTP) at hippocampal CA1 synapses by a presynaptic enhancement of synaptic transmission during high-frequency stimulation (HFS)...
  69. ncbi BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
    Z J Huang
    Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 98:739-55. 1999
    ..of the visual cortex in transgenic mice in which the postnatal rise of brain-derived neurotrophic factor (BDNF) was accelerated. In these mice, the maturation of GABAergic innervation and inhibition was accelerated...
  70. ncbi Epithelial overexpression of BDNF or NT4 disrupts targeting of taste neurons that innervate the anterior tongue
    R F Krimm
    Department of Pathology and Laboratory Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    Dev Biol 232:508-21. 2001
    Brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) are essential for the survival of geniculate ganglion neurons, which provide the sensory afferents for taste buds of the anterior tongue and palate...
  71. ncbi Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, Ohio 44272, USA
    Exp Neurol 170:121-8. 2001
    Deletion of a single copy of the BDNF gene has been shown to affect the nigrostriatal dopaminergic system of young adult BDNF mice...
  72. ncbi Dissection of NT3 functions in vivo by gene replacement strategy
    V Coppola
    Neural Development Group, Mouse Cancer Genetics Program, NCI, Frederick, MD 21701, USA
    Development 128:4315-27. 2001
    ..receptor interactions in vivo, we have replaced the Nt3 gene with the gene for brain-derived neurotrophic factor (BDNF), a TrkB ligand. As in NT3 and TrkC null mice, the proprioception system of these mutants failed to assemble...
  73. ncbi BDNF stimulates migration of cerebellar granule cells
    Paul R Borghesani
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Development 129:1435-42. 2002
    ..of cerebellar granule cells out of their proliferative zone, the external granule cell layer (EGL), is impaired in Bdnf(-/-) mice. The reason for impaired migration is that BDNF directly and acutely stimulates granule cell migration...
  74. ncbi Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
    Jaewon Lee
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 82:1367-75. 2002
    To determine the role of brain-derived neurotrophic factor (BDNF) in the enhancement of hippocampal neurogenesis resulting from dietary restriction (DR), heterozygous BDNF knockout (BDNF +/-) mice and wild-type mice were maintained for 3 ..
  75. ncbi BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development
    Karin Agerman
    Unit of Molecular Neurobiology, MBB, Karolinska Institutet, 171 77 Stockholm, Sweden
    Development 130:1479-91. 2003
    ..despite overlapping expression of TrkB and TrkC in many sensory ganglia, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) null mutant mice display selective losses in neuronal subpopulations...
  76. ncbi Brain-derived neurotrophic factor mediates activity-dependent dendritic growth in nonpyramidal neocortical interneurons in developing organotypic cultures
    Xiaoming Jin
    Department of Neurobiology and Anatomy, West Virginia University, Morgantown, West Virginia 26506 9128, USA
    J Neurosci 23:5662-73. 2003
    Brain-derived neurotrophic factor (BDNF) promotes postnatal maturation of GABAergic inhibition in the cerebral and cerebellar cortices, and its expression and release are enhanced by neuronal activity, suggesting that it acts in a ..
  77. ncbi Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
    Wen G Chen
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 302:885-9. 2003
    ..We find that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene...
  78. ncbi Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning
    Eija Koponen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Mol Cell Neurosci 26:166-81. 2004
    ..TK+ mice. Altogether, overexpression of the trkB.TK+ receptor postnatally leads to selective activation of trkB signaling pathways and enhanced learning and memory...
  79. pmc Essential role of brain-derived neurotrophic factor in adult hippocampal function
    Lisa M Monteggia
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 101:10827-32. 2004
    Brain-derived neurotrophic factor (BDNF) regulates neuronal development and function. However, it has been difficult to discern its role in the adult brain in influencing complex behavior...
  80. ncbi Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1
    Matthew E Szapacs
    Department of Chemistry and the Huck Institute for Life Sciences, The Pennsylvania State University, University Park, PA 16802 4615, USA
    Neurobiol Dis 16:572-80. 2004
    ..In addition, brain-derived neurotrophic factor (BDNF) protein levels were investigated since changes in BDNF are reported to occur in AD, and BDNF has been shown to ..
  81. ncbi Maturation but not survival of dopaminergic nigrostriatal neurons is affected in developing and aging BDNF-deficient mice
    Sarah A Baker
    Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY 40292, USA
    Brain Res 1039:177-88. 2005
    Brain-derived neurotrophic factor (BDNF) promotes survival of injured dopaminergic nigrostriatal neurons of the adult rodent substantia nigra pars compacta, as well their development in vitro...
  82. pmc Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention
    B Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
    Dev Dyn 233:570-83. 2005
    ..for growing afferent fibers, possibly through the release of the neurotrophin brain-derived neurotrophic factor (BDNF)...
  83. ncbi Presence of neurotrophic factors in skeletal muscle correlates with survival of spinal cord motor neurons
    Boris Kablar
    Dalhousie University, Faculty of Medicine, Department of Anatomy and Neurobiology, Halifax, Nova Scotia, Canada
    Dev Dyn 234:659-69. 2005
    ....
  84. ncbi Lingual deficits in neurotrophin double knockout mice
    Irina V Nosrat
    Laboratory of Oral Neurobiology, Department of Biological and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
    J Neurocytol 33:607-15. 2004
    Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) are members of the neurotrophin family and are expressed in the developing and adult tongue papillae...
  85. ncbi Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors
    Lisa M Monteggia
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Biol Psychiatry 61:187-97. 2007
    Indirect evidence suggests that loss of brain-derived neurotrophic factor (BDNF) from forebrain regions contributes to an individual's vulnerability for depression, whereas upregulation of BDNF in these regions is suggested to mediate the ..
  86. ncbi Regulation of preimplantation embryo development by brain-derived neurotrophic factor
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, 010 8543, Japan
    Dev Biol 311:147-58. 2007
    ..We found expression of brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5) transcripts at its highest levels in the blastocyst stages...
  87. ncbi Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity
    Thaddeus J Unger
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Neurosci 27:14265-74. 2007
    Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are expressed in several hypothalamic and hindbrain nuclei involved in regulating energy homeostasis, developmentally and in the adult animal...
  88. pmc A model for neuronal competition during development
    Christopher D Deppmann
    Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 320:369-73. 2008
    ..We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects...
  89. doi Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration
    Karun K Singh
    Developmental and Stem Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Canada M5G 1X8
    Nat Neurosci 11:649-58. 2008
    ..which, during developmental sympathetic axon competition, winning axons secrete brain-derived neurotrophic factor (BDNF) in an activity-dependent fashion, which binds to the p75 neurotrophin receptor (p75NTR) on losing axons to cause ..
  90. pmc A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons
    Joshua J Park
    Section on Cellular Neurobiology, Developmental Neurobiology Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA
    Mol Cell Neurosci 39:63-73. 2008
    Anterograde transport of brain-derived neurotrophic factor (BDNF) vesicles from the soma to neurite terminals is necessary for activity-dependent secretion of BDNF to mediate synaptic plasticity, memory and learning, and retrograde BDNF ..
  91. pmc Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons
    Juan Ji An
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    Cell 134:175-87. 2008
    The brain produces two brain-derived neurotrophic factor (BDNF) transcripts, with either short or long 3' untranslated regions (3' UTRs). The physiological significance of the two forms of mRNAs encoding the same protein is unknown...
  92. pmc Depletion of central BDNF in mice impedes terminal differentiation of new granule neurons in the adult hippocampus
    Jason P Chan
    Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
    Mol Cell Neurosci 39:372-83. 2008
    ..Here, we investigated the role of BDNF in facilitating their maturation in vivo...
  93. pmc A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition
    Elizabeth J Hong
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 60:610-24. 2008
    ..Here, we demonstrate that introduction of a subtle knockin mutation into the mouse Bdnf gene that blocks the ability of the activity-regulated factor CREB to bind Bdnf promoter IV results in an animal in ..
  94. pmc Mouse olfactory ensheathing glia enhance axon outgrowth on a myelin substrate in vitro
    Stephen A Runyan
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
    Exp Neurol 216:95-104. 2009
    ..if a cell adhesion molecule expressed by OEG, L1, and a factor secreted by OEG, brain-derived neurotrophic factor (BDNF), contribute to the ability of OEG to enhance axonal outgrowth on myelin...
  95. pmc Neuronal release of proBDNF
    Jianmin Yang
    Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, New York 10065, USA
    Nat Neurosci 12:113-5. 2009
    Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions...
  96. pmc Differential expression of neurotrophins in postnatal C57BL/6 mice striatum
    V Zermeño
    Unidad de Biomedicina, FES I, Universidad Nacional Autonoma de Mexico, Av de los Barrios 1, Los Reyes Iztacala, C P 54090 Tlalnepantla, Mexico
    Int J Biol Sci 5:118-27. 2009
    ..In the present study, immunocytochemical expression of BDNF, NT-3 and NT-4/5 was characterized in striatal tissue of C57BL/6 mice at postnatal days 10(th )(P10), 21(st) (P21), ..
  97. pmc Epithelial-derived brain-derived neurotrophic factor is required for gustatory neuron targeting during a critical developmental period
    Liqun Ma
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    J Neurosci 29:3354-64. 2009
    Brain-derived neurotrophic factor (BDNF) is expressed in epithelial targets of gustatory neurons (i.e...
  98. pmc Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior
    Anita E Autry
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 66:84-90. 2009
    ..The neurotrophic hypothesis of depression suggests that loss of brain-derived neurotrophic factor (BDNF) may increase susceptibility for depression-like behavior, although direct evidence is lacking.
  99. pmc Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease
    Shiyong Peng
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Neurosci 29:9321-9. 2009
    Downregulation of brain-derived neurotrophic factor (BDNF) in the cortex occurs early in the progression of Alzheimer's disease (AD)...
  100. pmc Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
    Mathew Blurton-Jones
    Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:13594-9. 2009
    ..involves a robust enhancement of hippocampal synaptic density, mediated by brain-derived neurotrophic factor (BDNF). Gain-of-function studies show that recombinant BDNF mimics the beneficial effects of NSC transplantation...
  101. pmc Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation
    C Chiaruttini
    BRAIN Centre for Neuroscience, Department of Life Sciences, and Dipartimento di Scienze Farmaceutiche, University of Trieste, 34127 Trieste, Italy
    Proc Natl Acad Sci U S A 106:16481-6. 2009
    Alternatively spliced brain-derived neurotrophic factor (BDNF) transcripts are targeted to distinct cellular compartments in neurons but the mechanisms underlying this sorting are unknown...

Research Grants31

  1. Genetic remodeling of Vagal Afferent Organization
    Edward Fox; Fiscal Year: 2009
    ..innervate the gastrointestinal (Gl) tract in mice with a mutation in either the brain-derived neurotrophic factor (BDNF) gene or the neurotrophin-3 (NT-3) gene...
  2. Region & Developmental Stage Specific Deletion of MeCP2 in Mouse Brain
    Lisa Monteggia; Fiscal Year: 2008
    ..The proposed studies should increase our understanding of the role of MeCP2 in mediating certain RTT associated behaviors as well as identify neural circuits that mediate these abnormalities. [unreadable] [unreadable] [unreadable]..
  3. ROD NEURODEGENERATIVE AND PROTECTIVE GENES
    Baerbel Rohrer; Fiscal Year: 2005
    ..However brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor, the two most widely used factors, do not act on the photoreceptors directly, but ..
  4. EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICS
    Schahram Akbarian; Fiscal Year: 2009
    ....
  5. Genetic Analysis of Age Related Hearing Impairment
    Rick A Friedman; Fiscal Year: 2010
    ..This improved knowledge base can be anticipated to constitute fertile ground for developing new evidence-based preventive and therapeutic approaches to treating ARHI. ..
  6. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce S McEwen; Fiscal Year: 2010
    ..abstract_text> ..
  7. DOPAMINERGIC SIGNALING MODIFIES STRATIAL HISTONES
    Schahram Akbarian; Fiscal Year: 2009
    ....
  8. Brain Development Following Institutionalization
    BETTY CASEY; Fiscal Year: 2008
    ..We will recruit a typically developing population of children to assess deviations or delays in the development of amygdala and hippocampal volume and function. [unreadable] [unreadable]..
  9. Proteoglycan degradation and functional recovery after peripheral nerve injury
    ARTHUR ENGLISH; Fiscal Year: 2007
    ..This proposal seeks to evaluate a technology for medical treatment of peripheral nerve injuries which, if successful, could have an important impact on a relatively large group of under-treated patients. [unreadable] [unreadable]..
  10. Replacing an Animal Resource Facility Cage Washer.
    Kristen Drescher; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. 5HT transporter & 1A receptor function in BDNF mice
    JULIE HENSLER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Brain-derived neurotrophic factor (BDNF) promotes serotonergic neurotransmission and the structural plasticity of serotonergic (5rHT) neurons in the adult brain...
  12. DEVELOPMENT OF EFFERENT NERVE FIBERS IN THE COCHLEA
    HANNA SOBKOWICZ; Fiscal Year: 2001
    ..plans to identify ultrastructurally the morphological and immunochemical character of vesiculated endings that express GAP-43 in the inner spiral bundle, the only neuronal pathway that contains this growth protein in the adult cochlea. ..
  13. Chromatin Pathology in Cerebral Cortex of Schizophrenics
    Schahram Akbarian; Fiscal Year: 2006
    ..Finally, the proposed studies will provide the framework for future proposals designed to map histone modification patterns across entire chromosomes in human brain, including alterations in major psychiatric disease. ..
  14. NEURAL PLASTICITY IN TASTE
    Bruce Oakley; Fiscal Year: 2001
    ..neurons and taste buds are affected by inactivation of genes for one or more of the neurotrophins NT-3, NT-4 and BDNF or their cognate tyrosine kinase receptors...
  15. NEUROTROPHINS IN NEURONAL SURVIVAL AND DIFFERENTIATION
    Xin Liu; Fiscal Year: 2004
    ..Neurotrophins are a four-member family of structurally related proteins; Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3) and Neurotrophin-4 (NT-4)...
  16. Muscle Gene Expression Biomarkers of HD
    Andrew Strand; Fiscal Year: 2006
    ..This aim of this proposal is to develop muscle gene expression changes in HD biomarkers that will be more sensitive to disease progression than the current clinical rating scale. ..
  17. Frontostriatal Development and Cognitive Control
    BETTY CASEY; Fiscal Year: 2005
    ....
  18. Transgenic Rod Development and Function
    Baerbel Rohrer; Fiscal Year: 2005
    ..However, more importantly, it will provide avenues for studying gene defects at the single cell level not only in the retina, but in other systems as well. ..
  19. Study of a genetic network involved in ear development
    Rick Friedman; Fiscal Year: 2005
    ..These and future experiments represent the natural progression from my Mentored Clinical Scientist Development Award (K08). ..
  20. Antigen Identification in Occult Chorioretinopathies
    Jeffrey Bennett; Fiscal Year: 2006
    ....
  21. Inhibition of trkB Dephosphorylation: A Novel Approach to Promote Neuron Survival
    Tami Kingsbury; Fiscal Year: 2008
    ..to reduced levels of dopamine, PD patients also exhibit reduced levels of the brain- derived neurotrophic factor BDNF (Mogi et al., 1999)...
  22. Development of Basic Components of Decision Making
    BETTY CASEY; Fiscal Year: 2008
    ..The proposed studies are in response to RFA # DA-04-009 Behavioral and Cognitive Processes Related to Adolescent Drug Abuse. ..
  23. Chromatin Alterations in Rett Syndrome
    Schahram Akbarian; Fiscal Year: 2009
    ..It is expected that these approaches will provide a clear and comprehensive picture on the developmental regulation of histone modifications in cortical neurons, including potential changes in MECP2-deficient brain. ..
  24. Treating Depression with Histone Deacetylase Inhibitors
    Schahram Akbarian; Fiscal Year: 2006
    ..abstract_text> ..
  25. Functional neuroanatomical deficits in ADHD families
    BETTY CASEY; Fiscal Year: 2003
    ..Imaging will be performed at corresponding imaging sites at DUMC, Weill Medical College of Cornell University, and Stanford University respectively. ..
  26. DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.
    Bernd Fritzsch; Fiscal Year: 2010
    ..will molecularly dissect the role of neurotrophins in neonatal and postnatal fiber reorganization using conditional Bdnf ear mutations in combination with transgenic misexpressors...
  27. REGULATION OF MASTICATORY MUSCLE FIBER PHENOTYPE
    ARTHUR ENGLISH; Fiscal Year: 2002
    ..The new knowledge generated will impact significantly several areas of clinical dentistry. ..
  28. Serotonin Receptor Subtypes: Regulation and Interaction
    JULIE HENSLER; Fiscal Year: 2008
    ..Studies of the regulation of 5-HT1A receptor function may have important implications for our understanding the role of this receptor in the therapeutic action of drugs used to treat mental illness [unreadable] [unreadable]..
  29. Development of Prediction and Reward Related Circuitry
    BETTY CASEY; Fiscal Year: 2004
    ..The proposed studies will lay the critical groundwork, both scientific and methodological, for subsequent studies on substance abuse in children. ..