Bcl2l11

Summary

Gene Symbol: Bcl2l11
Description: BCL2-like 11 (apoptosis facilitator)
Alias: 1500006F24Rik, Bim, Bod, bcl2-L-11, bcl-2-like protein 11, Bcl2 interacting mediator of cell death, bcl2-interacting mediator of cell death
Species: mouse

Top Publications

  1. ncbi ER stress triggers apoptosis by activating BH3-only protein Bim
    Hamsa Puthalakath
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell 129:1337-49. 2007
  2. ncbi Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    Lin Chen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria 3050, Australia
    Mol Cell 17:393-403. 2005
  3. pmc Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
    Peter D Hughes
    Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 28:197-205. 2008
  4. pmc Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development
    Verena Labi
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Exp Med 205:641-55. 2008
  5. pmc The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 12:434-40. 2011
  6. pmc Multisite phosphorylation regulates Bim stability and apoptotic activity
    Anette Hübner
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 30:415-25. 2008
  7. pmc LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis
    Takahiro Maeda
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 17:527-40. 2009
  8. ncbi Bim expression indicates the pathway to retinal cell death in development and degeneration
    Francesca Doonan
    Tumour Biology Laboratory, Biochemistry Department, Bioscience Research Institute, University College Cork, Cork, Republic of Ireland
    J Neurosci 27:10887-94. 2007
  9. doi Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction
    Ashley E Weant
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunity 28:218-30. 2008
  10. ncbi The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression
    Claudia Orelio
    Erasmus University Medical Centre, Department of Cell Biology and Genetics, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Blood 103:4084-92. 2004

Research Grants

  1. Testing therapeutic pathways in genetic glaucoma
    RICHARD LIBBY; Fiscal Year: 2004
  2. Immunosuppression and regulatory T cells in aging
    Claire Chougnet; Fiscal Year: 2006
  3. CD40 Ligand Dysregulation and HIV Pathogenesis
    Claire Chougnet; Fiscal Year: 2009
  4. Role of Regulatory T Cells in HIV Infection
    Claire A Chougnet; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications142 found, 100 shown here

  1. ncbi ER stress triggers apoptosis by activating BH3-only protein Bim
    Hamsa Puthalakath
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell 129:1337-49. 2007
    ..b>Bim, a proapoptotic BH3-only member of the Bcl-2 family is required for initiation of apoptosis induced by cytokine ..
  2. ncbi Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    Lin Chen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria 3050, Australia
    Mol Cell 17:393-403. 2005
    ..b>Bim and Puma potently engaged all the prosurvival proteins comparably...
  3. pmc Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
    Peter D Hughes
    Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 28:197-205. 2008
    ..We examined mice lacking the gene encoding Bim (Bcl2l11) and with the inactivating lpr mutation in the gene encoding Fas (Fas), designated Bcl2l11(-/-)Fas(lpr/lpr) mice...
  4. pmc Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development
    Verena Labi
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Exp Med 205:641-55. 2008
    ..Finally, Bmf-deficiency accelerated the development of gamma irradiation-induced thymic lymphomas. Our results demonstrate that Bmf plays a critical role in apoptosis signaling and can function as a tumor suppressor...
  5. pmc The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 12:434-40. 2011
    ..Our data establish an essential, cell-autonomous and context-sensitive function for ATP11C, a putative aminophospholipid flippase, in B cell development...
  6. pmc Multisite phosphorylation regulates Bim stability and apoptotic activity
    Anette Hübner
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 30:415-25. 2008
    The proapoptotic BH3-only protein Bim is established to be an important mediator of signaling pathways that induce cell death...
  7. pmc LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis
    Takahiro Maeda
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 17:527-40. 2009
    ..programmed cell death is Arf and p53 independent and is instead mediated by upregulation of the proapoptotic factor Bim. We identify Lrf as a direct repressor of Bim transcription...
  8. ncbi Bim expression indicates the pathway to retinal cell death in development and degeneration
    Francesca Doonan
    Tumour Biology Laboratory, Biochemistry Department, Bioscience Research Institute, University College Cork, Cork, Republic of Ireland
    J Neurosci 27:10887-94. 2007
    ..The purpose of this study was to investigate a possible role for Bim, in retinal development and degeneration, upstream of Bax and Bak...
  9. doi Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction
    Ashley E Weant
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunity 28:218-30. 2008
    ..Mutation of Bim, a proapoptotic protein in the intrinsic death pathway, or Fas, a tumor necrosis factor receptor (TNFR) superfamily ..
  10. ncbi The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression
    Claudia Orelio
    Erasmus University Medical Centre, Department of Cell Biology and Genetics, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Blood 103:4084-92. 2004
    ..Most important, our in vivo transplantation data show that Bcl-2 overexpression increases AGM and fetal liver HSC activity, strongly suggesting that apoptosis plays a role in HSC development...
  11. pmc Bim is responsible for the inherent sensitivity of the developing retinal vasculature to hyperoxia
    Shoujian Wang
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Dev Biol 349:296-309. 2011
    ..Bcl-2 family members, such as bim not only influence apoptosis, but also cell adhesive and migratory properties essential during vascular development...
  12. pmc Deficiency of pro-apoptotic Hrk attenuates programmed cell death in the developing murine nervous system but does not affect Bcl-x deficiency-induced neuron apoptosis
    Arindam P Ghosh
    Department of Pathology, University of Alabama at Birmingham, USA
    J Histochem Cytochem 59:976-83. 2011
    ....
  13. doi PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
    ..These data suggest a requirement for PDK-1 and FoxO1 in transcriptional regulation of Pomc and food intake...
  14. ncbi Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    Mamm Genome 12:163-8. 2001
    b>Bim is a proapoptotic protein of the Bcl-2 family that shares only the short BH3 domain with other members. It has three isoforms, apparently produced by alternative splicing...
  15. ncbi Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    Joseph T Opferman
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Department of Pathology and Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 426:671-6. 2003
    ..Thus, MCL-1, which selectively inhibits the proapoptotic protein BIM, is essential both early in lymphoid development and later on in the maintenance of mature lymphocytes.
  16. ncbi Reactive oxygen species regulate quiescent T-cell apoptosis via the BH3-only proapoptotic protein BIM
    H Sade
    National Centre for Biological Sciences, UAS GKVK Campus, Bangalore, India
    Cell Death Differ 11:416-23. 2004
    ..peripheral T cells cultured in the absence of survival factors accumulate reactive oxygen species (ROS), upregulate BIM (Bcl-2-interacting mediator of death) and inducible nitric oxide synthase (iNOS) expression, culminating in Fas-..
  17. pmc Loss of Bim allows precursor B cell survival but not precursor B cell differentiation in the absence of interleukin 7
    Paula M Oliver
    Howard Hughes Medical Institute, Dept of Immunology, 1400 Jackson St, Denver, CO 80206, USA
    J Exp Med 200:1179-87. 2004
    ..versus B cell differentiation, the combined effects of lack of IL-7 and lack of the proapoptotic Bcl-2 relative, Bim, were studied. Bim is expressed to varying degrees in all B cell precursors and B cells...
  18. pmc TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality
    Nadia Corazza
    Division of Immunopathology, Institute of Pathology, University of Bern, Bern, Switzerland
    J Clin Invest 116:2493-9. 2006
    ..hepatocyte apoptosis through the activation of JNK and its downstream substrate, the proapoptotic Bcl-2 homolog Bim. Consistently, TRAIL- and Bim-deficient mice and wild-type mice treated with a JNK inhibitor were protected against ..
  19. pmc Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma
    R K Lindemann
    Cancer Immunology Program, The Peter MacCallum Cancer Institute, Trescowthick Research Laboratories, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Proc Natl Acad Sci U S A 104:8071-6. 2007
    ..but depended on activation of the intrinsic apoptotic pathway with the proapoptotic BH3-only proteins Bid and Bim playing an important role...
  20. pmc RACK1 and CIS mediate the degradation of BimEL in cancer cells
    Weizhou Zhang
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 283:16416-26. 2008
    ..Additionally, we demonstrated that RACK1 formed a complex with DLC1 and Bim, specifically BimEL, in the presence of apoptotic agents...
  21. ncbi BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O The Royal Melbourne Hospital, Victoria 3050, Australia
    Nature 415:922-6. 2002
    ..We now report that thymocytes lacking the pro-apoptotic Bcl-2 family member Bim (also known as Bcl2l11) are refractory to apoptosis induced by TCR-CD3 stimulation...
  22. ncbi The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
    Xinqi Liu
    Howard Hughes Medical Institute, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Immunity 19:341-52. 2003
    ..of T cells involved in an immune response die rapidly by apoptosis dependent on the Bcl-2 related proteins, Bim and Bax or Bak. The details of how these proteins are activated and interact are still unclear...
  23. pmc Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
    Marc Pellegrini
    Division of Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia
    Proc Natl Acad Sci U S A 100:14175-80. 2003
    We used mutant Fas-deficient (lpr) or Bim-deficient mice to investigate the role of the death receptor and Bcl-2-regulated apoptotic pathways in terminating a physiological T cell response to herpes simplex virus infection...
  24. pmc Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim
    Toru Akiyama
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    EMBO J 22:6653-64. 2003
    ..apoptosis was associated with a rapid and sustained increase in the pro-apoptotic BH3-only Bcl-2 family member Bim. This was caused by the reduced ubiquitylation and proteasomal degradation of Bim that is mediated by c-Cbl...
  25. pmc Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells
    Yanan Zhu
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:7681-6. 2004
    Apoptosis in activated T cells in vivo requires the proapoptotic Bcl-2 family member Bim. We show here that, despite its ability to bind LC8, a component of the microtubule dynein motor complex, most of the Bim in both healthy and ..
  26. ncbi Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrins
    Pengbo Wang
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 279:41280-5. 2004
    ..The Bcl-2 homology 3 domain-only protein, Bim, has been proposed to have a key role in the apoptosis response of an epithelial cell line with reduced sensitivity ..
  27. pmc Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis
    Yoshinori Takahashi
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 25:9369-82. 2005
    ..Taken together, these findings support the notion that Bif-1 is an important component of the mitochondrial pathway for apoptosis as a novel Bax/Bak activator, and loss of this proapoptotic molecule may contribute to tumorigenesis...
  28. pmc A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival
    Laurent Sabbagh
    Department of Immunology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Proc Natl Acad Sci U S A 103:18703-8. 2006
    ..TRAF1-deficient, antigen-activated T cells accumulated higher levels of the proapoptotic BH3-only family member Bim, particularly the most toxic isoform, Bim(S)...
  29. pmc Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
    Miriam Erlacher
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Exp Med 203:2939-51. 2006
    ..3-only proteins has been investigated in mice lacking the individual genes identifying rate-limiting roles for Bim (Bcl-2-interacting mediator of cell death) and Puma (p53-up-regulated modulator of apoptosis) in apoptosis ..
  30. pmc Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa
    Edwina Naik
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Cell Biol 176:415-24. 2007
    ..In the transformed derivatives, where Puma, unexpectedly, was not induced by UVR, Noxa had the dominant role and Bim a minor role...
  31. ncbi Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    Simon N Willis
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Science 315:856-9. 2007
    ..show that Bax and Bak can mediate apoptosis without discernable association with the putative BH3-only activators (Bim, Bid, and Puma), even in cells with no Bim or Bid and reduced Puma...
  32. pmc BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins
    Arnim Weber
    Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universitat Munchen, Munich, Germany
    J Cell Biol 177:625-36. 2007
    ..Here, we analyze apoptosis induction by the BH3-only protein Bim(S)...
  33. pmc Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis
    Nicholas T Woods
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Cancer Res 67:10744-52. 2007
    ..Using wild-type and c-Src-transformed NIH3T3 cells as a model, we identified Mcl-1 degradation and Bim up-regulation as a critical determinant of anoikis initiation...
  34. doi Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1
    Catherine L Day
    Department of Biochemistry, University of Otago, Dunedin 9054, New Zealand
    J Mol Biol 380:958-71. 2008
    ..Thermodynamic parameters for the interaction of Noxa, Puma and the related BH3 domains of Bmf, Bim, Bid and Bak with Mcl-1 were determined by calorimetry...
  35. doi Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim
    A M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Victoria, Australia
    Cell Death Differ 16:555-63. 2009
    ..Puma rapidly induced apoptosis in cells lacking the BH3-only proteins, Bid and Bim. Puma expression resulted in activation of Bax, but Puma killing was not dependent on Bax or Bak alone as Puma ..
  36. pmc Bim: a novel member of the Bcl-2 family that promotes apoptosis
    L O'Connor
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:384-95. 1998
    ..An expression screen for proteins that bind to Bcl-2 yielded a small novel protein, denoted Bim, whose only similarity to any known protein is the short (nine amino acid) BH3 motif shared by most Bcl-2 ..
  37. ncbi The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
    H Puthalakath
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Mol Cell 3:287-96. 1999
    ..We examined the regulation of the proapoptotic activity of the BH3-only protein Bim. In healthy cells, most Bim molecules were bound to LC8 cytoplasmic dynein light chain and thereby sequestered to ..
  38. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999
    Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share only the BH3 domain with this family. Gene targeting in mice revealed important physiological roles for Bim...
  39. ncbi Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
    H Puthalakath
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O Royal Melbourne Hospital, 3050 Vic, Australia
    Science 293:1829-32. 2001
    ..Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures.
  40. ncbi Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Dev Cell 1:645-53. 2001
    ..To test whether loss of the BH3-only protein Bim could prevent the cellular attrition caused by Bcl-2 deficiency, we generated mice lacking both genes...
  41. ncbi Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim
    David A Hildeman
    Howard Hughes Medical Institute and Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunity 16:759-67. 2002
    ..We also found that Vbeta8(+) T cells from Bim-deficient mice are resistant to SEB-induced deletion...
  42. ncbi Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
    Vanessa S Marsden
    The Walter and Eliza Hall Institute, Melbourne, 3050, Australia
    Nature 419:634-7. 2002
    ..We conclude that Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 'apoptosome', which seems to amplify rather than initiate the caspase cascade...
  43. ncbi Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival
    Andreas Villunger
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 101:2393-400. 2003
    ..mice to investigate the roles of the prosurvival molecules Bcl-2 and Bcl-w and their proapoptotic relatives Bax and Bim in spontaneous and stress-induced apoptosis of granulocytes from bone marrow or the peritoneum...
  44. pmc Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells
    Anselm Enders
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Exp Med 198:1119-26. 2003
    ..Here we report that B lymphocytes lacking the pro-apoptotic Bcl-2 family member Bim are refractory to apoptosis induced by BCR ligation in vitro...
  45. pmc Bim is a suppressor of Myc-induced mouse B cell leukemia
    Alexander Egle
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:6164-9. 2004
    ..b>Bim, a distant proapoptotic relative, is emerging as a major physiologic antagonist of Bcl2...
  46. pmc Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
    Andreas Villunger
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:7052-7. 2004
    ..independently of Fas and "death receptor" signaling in general but required the proapoptotic BH3-only protein Bim and could be inhibited by Bcl-2...
  47. pmc BAD is a pro-survival factor prior to activation of its pro-apoptotic function
    So Young Seo
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD21205, USA
    J Biol Chem 279:42240-9. 2004
    ..These findings suggest that BAD is more than an inert death factor in healthy cells; it is also a pro-survival factor, prior to its role in promoting cell death...
  48. pmc Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity
    Hisashi Harada
    Department of Internal Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 101:15313-7. 2004
    ..A small interfering RNA knockdown of BIM confirms this BH3-only member is important for the cytokine-mediated homeostasis of hematopoietic cells...
  49. pmc Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice
    Marc Pellegrini
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Exp Med 200:1189-95. 2004
    ..BH3-only proteins such as Bim, which are distant proapoptotic members of the Bcl-2 family, are essential initiators of programmed cell death and ..
  50. ncbi Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim
    Adrian Liston
    Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, 2601, Australia
    Immunity 21:817-30. 2004
    ..signaling to prosurvival genes but is distinguished by failure to induce the proapoptotic gene and protein, Bim, during in vivo encounter with high-avidity autoantigen...
  51. ncbi Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
    Ting Ting Tan
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA
    Cancer Cell 7:227-38. 2005
    ..Here we demonstrate that the proapoptotic BH3-only protein BIM is a tumor suppressor in epithelial solid tumors and also is a determinant in paclitaxel sensitivity in vivo...
  52. ncbi Regulation of Bim by TCR signals in CD4/CD8 double-positive thymocytes
    Anna Bunin
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 175:1532-9. 2005
    b>Bim, a BH3-only Bcl-2 family member, is required for apoptosis of thymocytes in response to negative selection signals. Regulation of the apoptotic activity of Bim during negative selection is not understood...
  53. pmc Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease
    Osamu Takeuchi
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:11272-7. 2005
    ..Furthermore, inducible deletion of Bax and Bak in adult mice results in the development of severe autoimmune disease...
  54. pmc BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo
    Miriam Erlacher
    Division of Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Blood 106:4131-8. 2005
    ..types of cultured cells, 3 BH3-only proteins, namely Puma (p53 up-regulated modulator of apoptosis), Noxa, and Bim (Bcl-2 interacting mediator of cell death), have been shown to initiate p53-dependent as well as p53-independent ..
  55. pmc Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis
    Leigh Coultas
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    EMBO J 24:3963-73. 2005
    ..phenotype, as in mice lacking Bik, or to marked cell excess, as in the hematopoietic compartment of animals lacking Bim. To investigate whether functional redundancy with Bim might obscure a significant role for Bik, we generated mice ..
  56. ncbi Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected]
    Kirsten Canté-Barrett
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, CA 94305, USA
    J Immunol 176:2299-306. 2006
    ..whereas negative selection requires the proapoptotic Bcl-2 family member Bcl-2-interacting mediator of cell death (Bim)...
  57. ncbi Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets
    M G Hinds
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Cell Death Differ 14:128-36. 2007
    ..We show, using spectroscopic methods, that the BH3-only proteins Bim, Bad and Bmf are unstructured in the absence of binding partners...
  58. ncbi Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma
    Paul G Ekert
    Children s Cancer Centre, Murdoch Children s Research Centre, Royal Children s Hospital, Flemington Rd, Parkville, Victoria 3052, Australia
    Blood 108:1461-8. 2006
    ..Bad and Bim are 2 such BH3-only Bcl-2 family members that have been implicated as key initiators in apoptosis following growth ..
  59. pmc Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory
    Sara Wojciechowski
    Division of Immunobiology, Cincinnati Children s Hospital and the University of Cincinnati, Cincinnati, OH 45229, USA
    Eur J Immunol 36:1694-706. 2006
    ..The pro-apoptotic Bcl-2 family member, Bcl-2 interacting mediator of death (Bim) is critical for eliminating most effector T cells, while expression of CD127 (IL-7Ralpha) has been proposed to ..
  60. ncbi Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia
    Jayne M Ness
    Department of Pediatrics, University of Alabama at Birmingham, 35487, USA
    Brain Res 1099:150-9. 2006
    ..The Bcl-2 protein family consists of both pro- (e.g. Bax, Bad, Bid, Bim) and anti-apoptotic (e.g...
  61. ncbi Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia
    Joseph Pierce
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr, SE, Albuquerque, NM 87108, USA
    Am J Physiol Lung Cell Mol Physiol 291:L862-70. 2006
    ..b>Bim initiates negative selection of autoreactive T and B cells and shut down of T cell immune responses in vivo...
  62. pmc Role of Bim in regulating CD8+ T-cell responses during chronic viral infection
    Jason M Grayson
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Virol 80:8627-38. 2006
    Apoptosis is critical for the development and maintenance of the immune system. The proapoptotic Bcl-2 family member Bim is important for normal immune system homeostasis...
  63. ncbi The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein Bax
    John M Taylor
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 281:39728-39. 2006
    ....
  64. pmc Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity
    Min Chen
    Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Blood 109:4360-7. 2007
    ..b>Bim, a BH3-only protein of the Bcl-2 family, was expressed at low levels in DCs and was significantly up-regulated by ..
  65. ncbi A Critical role for Bim in retinal ganglion cell death
    Declan P McKernan
    Cell Development and Disease Laboratory, Department of Biochemistry, Biosciences Institute, University College, Cork, Ireland
    J Neurochem 102:922-30. 2007
    ..death in the central nervous system, we wished to investigate the role of Bcl-2 interacting mediator of cell death (Bim), a prominent member of this protein family in the regulation of cell death in the RGC layer using in vitro retinal ..
  66. pmc Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis
    Sara Wojciechowski
    Division of Immunobiology, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Exp Med 204:1665-75. 2007
    We examined the role of the antiapoptotic molecule Bcl-2 in combating the proapoptotic molecule Bim in control of naive and memory T cell homeostasis using Bcl-2(-/-) mice that were additionally deficient in one or both alleles of Bim...
  67. pmc Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 8:856-63. 2007
    ..Here we identify Bim, Noxa and Mcl-1 as key regulators of IL-15-dependent survival of NK cells...
  68. pmc Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells
    Silke F Fischer
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 110:3978-84. 2007
    ..In this study, we examined the role of the BH3-only protein Bim, an initiator of apoptosis in the Bcl-2-regulated pathway, in the programmed cell death accompanying an immune ..
  69. ncbi Bim and Bcl-2 mutually affect the expression of the other in T cells
    Trine N Jorgensen
    Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 179:3417-24. 2007
    ..The antiapoptotic protein Bcl-2 and the proapoptotic protein Bim are particularly important in this process with the amount of Bcl-2 per cell dropping by about one-half when T ..
  70. ncbi CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    Pushpa Pandiyan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 8:1353-62. 2007
    ..T(reg) cell-induced effector CD4+ T cell death required the proapoptotic protein Bim, and effector CD4+ T cells incubated with T(reg) cells showed less activation of the prosurvival kinase Akt and ..
  71. ncbi Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis
    Diana Steckley
    Robarts Research Institute and the Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5K8
    J Neurosci 27:12989-99. 2007
    ..study, we demonstrate that, in cortical neurons, oxidative stress induces the expression of the BH3-only members Bim, Noxa, and Puma...
  72. pmc Calcineurin sets the bandwidth for discrimination of signals during thymocyte development
    Elena M Gallo
    Howard Hughes Medical Institute and the Department of Pathology, Stanford University, Stanford, California 94305, USA
    Nature 450:731-5. 2007
    ..Analysis of mice deficient in both Bim (which is required for negative selection) and calcineurin revealed that calcineurin-induced ERK (extracellular ..
  73. pmc Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunity
    Stacie Reckling
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio 45229, USA
    Infect Immun 76:1179-85. 2008
    ..response, most of the activated effector T cells die by apoptosis driven by the proapoptotic Bcl-2 family member Bim (Bcl-2-interacting mediator of death)...
  74. doi Bax deficiency promotes an up-regulation of Bim(EL) and Bak during striatal and cortical postnatal development, and after excitotoxic injury
    N Gavalda
    Departament de Biologia Cel lular i Anatomia Patològica, Universitat de Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Mol Cell Neurosci 37:663-72. 2008
    ..wild-type animals, Bax knockout mice showed region- and time-dependent increases in pro-apoptotic proteins Bak and Bim(EL)...
  75. doi Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity
    Jack Hutcheson
    Department of Molecular Microbiology and Immunology, School of Medicine, Saint Louis University, Saint Louis, MO 63104, USA
    Immunity 28:206-17. 2008
    ..Further, mice (Bcl2l11(-/-)Fas(lpr/lpr)) lacking the Bcl-2 pro-apoptotic member, Bim (Bcl2l11(-/-)) and and with an lpr mutation in the ..
  76. pmc BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection
    Silke F Fischer
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne VIC 3050, Australia
    Proc Natl Acad Sci U S A 105:3035-40. 2008
    ..is mediated by the Bcl-2-regulated apoptotic pathway and partly depends on the proapoptotic BH3-only protein Bim. However, loss of Bim enhanced survival of antigen-activated T cells to a lesser extent than Bcl-2 overexpression, ..
  77. ncbi The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen
    William L Redmond
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 180:5275-82. 2008
    ..death pathway that could be inhibited by overexpression of Bcl-2 or targeted deletion of the proapoptotic molecule, Bim, thereby resulting in accumulation of activated clone 4 T cells...
  78. doi EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency
    E F Lee
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cell Death Differ 15:1609-18. 2008
    ..intermediate affinity only occurs when this EGL-1 BH3 domain is placed in a more stable context, namely that of Bim(S), which allows higher expression, though the kinetics of cell death now vary depending on whether Mcl-1 is ..
  79. pmc Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
    Desiree A Steimer
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 113:2805-15. 2009
    ..The loss of mature neutrophils induced by Mcl-1 deletion was not rescued by genetic deletion of proapoptotic Bim and Puma or by exogenous cytokine treatment...
  80. pmc Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim
    Thomas Kaufmann
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia
    Immunity 30:56-66. 2009
    ..However, combined loss of Bid and another BH3-only protein, Bim, activated by c-Jun N-terminal kinase (JNK), protected mice from LPS+GalN-induced hepatitis...
  81. pmc Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice
    Maciej W Ludwinski
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:1706-13. 2009
    b>Bim, the B cell lymphoma 2-interacting (Bcl2-interacting) mediator, maintains immunological tolerance by deleting autoreactive lymphocytes through apoptosis...
  82. pmc Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1
    Shuang Chen
    Department of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Mol Cell Biol 29:6149-69. 2009
    The Bcl-2 antagonist ABT-737 kills transformed cells in association with displacement of Bim from Bcl-2...
  83. pmc Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo
    Anette Hübner
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Mol Cell Biol 30:98-105. 2010
    ..Studies of compound mutants with the related gene Bim demonstrated that Bim and Bmf exhibit partially redundant functions in vivo...
  84. pmc Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis
    Hyungjin Kim
    Molecular Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell 36:487-99. 2009
    ..The activator BH3s, tBID/BIM/PUMA, attack and expose the alpha1 helix of BAX, resulting in secondary disengagement of the alpha9 helix and ..
  85. doi Bim-mediated apoptosis is not necessary for thymic negative selection to ubiquitous self-antigens
    Qian Hu
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 183:7761-7. 2009
    ..questions that surround the mechanism of negative selection, but it is currently held that apoptosis initiated by Bim and/or Nur77 is critical for negative selection...
  86. pmc Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax
    Mark D McKenzie
    St Vincent s Institute, Melbourne, Australia
    Diabetes 59:644-52. 2010
    ..We investigated the apoptotic pathway induced in mouse pancreatic islet cells after exposure to high concentrations of the reducing sugars ribose and glucose as a model of beta-cell death due to long-term metabolic stress...
  87. pmc Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance
    Kirsteen J Campbell
    Molecular Genetics of CancerDivision, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia
    Blood 116:3197-207. 2010
    ..Collectively, these results demonstrate that Mcl-1 overexpression renders hematopoietic cells refractory to many cytotoxic insults, perturbs lymphopoiesis and promotes malignant transformation of hematopoietic stem and progenitor cells...
  88. pmc Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation
    Karen A Fortner
    Vermont Center for Immunology and Infectious Disease, The University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Eur J Immunol 40:3043-53. 2010
    ..regulates apoptosis in response to repeated TCR stimulation, whereas the Bcl-2 homology domain 3-only protein Bim mediates cytokine withdrawal-induced apoptosis...
  89. pmc A major role for Bim in regulatory T cell homeostasis
    Claire A Chougnet
    Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 186:156-63. 2011
    ..Notably, aged Treg exhibit decreased expression of the proapoptotic molecule Bim compared with Treg from young mice...
  90. pmc BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program
    Decheng Ren
    Molecular Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 330:1390-3. 2010
    ..We provide in vivo evidence demonstrating an essential role of the proteins BID, BIM, and PUMA in activating BAX and BAK...
  91. pmc Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim
    Sema Kurtulus
    Division of Immunobiology, Department of Pediatrics, University of Cincinnati College of Medicine and Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 186:5729-37. 2011
    ..Surprisingly, we found that these effector KLRG1(low)CD127(high) CD8(+) T cells also had increased levels of Bim compared with KLRG1(high)CD127(low) cells...
  92. pmc Dampening of death pathways by schnurri-2 is essential for T-cell development
    Tracy L Staton
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 472:105-9. 2011
    ..Our findings uncover a critical regulator of T-cell development that controls the balance between death and differentiation...
  93. pmc Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells
    Yifan Zhan
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Immunol 187:1566-77. 2011
    ..TCRs, evident from a prominent increase in self-superantigen-specific Foxp3(+)Vβ5(+)CD4(+) T cells in BALB/c Bim(-/-) mice compared with control animals...
  94. pmc Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways
    Andrea L Szymczak-Workman
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 187:4416-20. 2011
    ..We show that Tregs are able to suppress the proliferation of conventional T cells that are resistant to apoptosis (Bim(-/-), Bim(-/-)Puma(-/-), Bcl-2 transgenic) or receptor-interacting serine-threonine kinase-dependent necrosis (also ..
  95. pmc Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance
    Maikel L Colli
    Laboratory of Experimental Medicine, Medical Faculty, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS Pathog 7:e1002267. 2011
    ..Mcl-1 decrease results in the release of the BH3-only protein Bim, which activates the mitochondrial pathway of apoptosis...
  96. pmc Bim mediates the elimination of functionally unfit Th1 responders from the memory pool
    David C Jay
    Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e67363. 2013
    ..transition from effector to memory is accompanied by enhanced expression of the pro-apoptotic Bcl-2 family member Bim. Here, we show that Bim deficiency enables the survival of poorly functional Th1 responders that are normally ..
  97. doi A novel mechanism underlying the basic defensive response of macrophages against Mycobacterium infection
    Takuya Iyoda
    Department of Molecular Patho Physiology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba 278 8510, Japan
    J Immunol 192:4254-62. 2014
    ..infection induced activation of ERK1/2, which in turn caused phosphorylation/activation of the proapoptotic protein Bim in mouse macrophage-like Raw 264.7 cells...
  98. pmc Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells
    Yoann Marechal
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Faculte de Medecine, Universite Libre de Bruxelles, Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 104:13978-83. 2007
    ..The decreased B cell survival is associated with a decreased phosphorylation of Erk1/2 and increased Bim gene expression...
  99. pmc Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells
    Masatoshi Ohgushi
    Graduate School of Biostudies, Kyoto University, SCRB Building G, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 25:10017-28. 2005
    ..In addition, treatment with TGF-beta induced binding of Bim, a proapoptotic Bcl-2 homology domain 3 (BH3)-only protein, to Bcl-X(L), which is dependent on the activation of ..
  100. pmc Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease
    Celine Perier
    Research Institute University Hospital Vall d Hebron, 08035 Barcelona, Spain
    Proc Natl Acad Sci U S A 104:8161-6. 2007
    ..Bax mitochondrial translocation in this model relies mainly on the JNK-dependent activation of the BH3-only protein Bim. Targeting either Bax transcriptional induction or Bax mitochondrial translocation results in a marked attenuation ..
  101. doi Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons
    Jyh Rong Chao
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 452:98-102. 2008
    ..Together, the results identify a previously unknown sequence of interactions involving a Bcl-2-family-related protein and mitochondrial proteases in the ability to resist the induction of apoptosis when cytokines are limiting...

Research Grants4

  1. Testing therapeutic pathways in genetic glaucoma
    RICHARD LIBBY; Fiscal Year: 2004
    ..These experiments will provide insight into pathways responsible for pressure induced RGC degeneration. Additionally these experiments will provide insight into the location of neuronal insults in glaucoma. ..
  2. Immunosuppression and regulatory T cells in aging
    Claire Chougnet; Fiscal Year: 2006
    ..abstract_text> ..
  3. CD40 Ligand Dysregulation and HIV Pathogenesis
    Claire Chougnet; Fiscal Year: 2009
    ..abstract_text> ..
  4. Role of Regulatory T Cells in HIV Infection
    Claire A Chougnet; Fiscal Year: 2010
    ....