Genomes and Genes
Gene Symbol: Bcl2l1
Description: BCL2-like 1
Alias: Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-x, bcl2-L-1, bcl-2-like protein 1, B-cell leukemia/lymphoma x, anti-apoptosis regulatory protein, apoptosis regulator Bcl-X
Publications132 found, 100 shown here
- Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1M Chiara Maiuri
INSERM U848, Villejuif, France
EMBO J 26:2527-39. 2007..BH3-only proteins and pharmacological BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin-1 and Bcl-2 or Bcl-X(L)...
- Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemiaStefan P Glaser
The Walter and Eliza Hall Institute, Parkville, Melbourne, Victoria 3052, Australia
Genes Dev 26:120-5. 2012..Thus, targeting of Mcl-1 or regulators of its expression may be a useful strategy for the treatment of AML...
- bcl-xL and RAG genes are induced and the response to IL-2 enhanced in EmuEBNA-1 transgenic mouse lymphocytesPenelope Tsimbouri
Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 6NU, UK
Oncogene 21:5182-7. 2002..These data shed new light on the potential contribution of EBNA-1 to EBV associated tumorigenicity as well as to the viral life cycle and open a potential avenue for therapeutic intervention...
- Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liverHayato Hikita
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
Hepatology 50:1217-26. 2009..5 of embryogenesis and rapidly died within 1 day after birth, developing hepatic failure evidenced by increased levels of blood ammonia and bilirubin...
- Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cellsHongbin Deng
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Tian Tan Xi Li, Beijing 100050, China
Int J Biochem Cell Biol 43:409-15. 2011..Replacement of threonine 201 by alanine in Bad promoted Epo withdrawal-induced apoptosis. Thus, our results provide a molecular mechanism by which JNK1 contributes to the survival of erythroid cells...
- Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistagesT Kodama
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
Cell Death Differ 19:1856-69. 2012..In conclusion, Mcl-1 and Bcl-xL regulate the survival of the megakaryocytic lineage, which is critically important for preventing lethal or severe hemorrhage in both developing and adult mice...
- Mcl-1 is essential for germinal center formation and B cell memoryIngela Vikstrom
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
Science 330:1095-9. 2010..We investigated the consequences of deleting genes encoding the anti-apoptotic molecules Mcl1 and Bcl2l1 (Bcl-x(L)) from B cells using an inducible system synchronized with expression of activation-induced cytidine ..
- Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosisLi Xue
Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:6925-30. 2002..Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis...
- The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stagesIvan Dzhagalov
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 181:521-8. 2008..Furthermore, we demonstrate that Mcl-1 functions together with Bcl-xL to promote double-positive thymocyte survival. Thus, Mcl-1 is a critical anti-apoptotic factor for the survival of T cells at multiple stages in vivo...
- MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domainsK O Tan
Institute of Molecular and Cell Biology, 30 Medical Dr, Singapore 117609, Republic of Singapore
J Biol Chem 276:2802-7. 2001..These data suggest that MAP-1 mediates apoptosis through a mechanism that involves binding to Bax...
- Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptorsChi Li
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 99:9830-5. 2002..These results suggest that even under non-apoptotic conditions, expression of Bcl-2-family proteins influences a signaling network that links changes in mitochondrial metabolism to alterations in nuclear gene expression...
- GATA-4 incompletely substitutes for GATA-1 in promoting both primitive and definitive erythropoiesis in vivoSakie Hosoya-Ohmura
Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305 8577, Japan
J Biol Chem 281:32820-30. 2006..These data thus show a functional incompatibility between hematopoietic and endodermal GATA factors in vivo and provide evidence indicating specific roles of the C-terminal region of GATA-1 in primitive erythropoiesis...
- EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potencyE F Lee
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Cell Death Differ 15:1609-18. 2008..These results demonstrate how levels of BH3-only proteins, target affinity and the spectrum of neutralization of pro-survival proteins all contribute to killing activity...
- Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic miceD A Grillot
Department of Pathology, University of Michigan, Ann Arbor 48109 0608, USA
J Exp Med 182:1973-83. 1995..In contrast to Bcl-2, which has been implicated in the maintenance of mature T cells, Bcl-xL appears to provide a survival signal for the maintenance of more immature CD4+CD8+ thymocytes before positive selection...
- bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondriaM Gonzalez-Garcia
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
Development 120:3033-42. 1994..Based on its tissue and developmental patterns of expression, it appears that bcl-x may play an important role in the regulation of cell death during development and tissue homeostasis...
- Bcl-XL and Bcl-2 repress a common pathway of cell deathD T Chao
Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Exp Med 182:821-8. 1995..Immunoprecipitation indicated that Bcl-xL, like Bcl-2, heterodimerized with the death-promoting molecule Bax in thymocytes. This in vivo model argues that Bcl-xL, like Bcl-2, functions in a common pathway to repress cell death...
- Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient miceN Motoyama
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110
Science 267:1506-10. 1995..The life-span of immature lymphocytes, but not mature lymphocytes, was shortened. Thus, Bcl-x functions to support the viability of immature cells during the development of the nervous and hematopoietic systems...
- Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgeneW Fang
Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
Immunity 4:291-9. 1996..This analysis also demonstrated that immunoglobulin gene rearrangement is less precise than previously appreciated...
- Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cellsK Heermeier
Laboratory of Biochemistry and Metabolism, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1812, USA
Mech Dev 56:197-207. 1996..These findings point to a significant role for Bax and Bcl-xS in the regulation of apoptosis of secretory alveolar cells during involution...
- The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitorsP Naik
Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0534, USA
Genes Dev 10:2105-16. 1996..Thus, down-modulation of apoptosis selectively contributes to late steps in a tumorigenesis pathway...
- Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x geneD A Grillot
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
J Immunol 158:4750-7. 1997..12 and K562 cell lines. The remarkable similarity between the genomic regions of bcl-2 and bcl-x suggests that these genes have evolved from a common ancestral gene or through gene duplication...
- Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response geneS P Tzung
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
Am J Pathol 150:1985-95. 1997..In summary, the expression profiles of Bcl-2 family members during liver regeneration suggest a cell-cycle-dependent regulation as well as a physiological role for these apoptosis-modulating genes during growth and proliferation...
- Bim: a novel member of the Bcl-2 family that promotes apoptosisL O'Connor
The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
EMBO J 17:384-95. 1998..Hence, Bim appears to act as a 'death ligand' which can only neutralize certain members of the pro-survival Bcl-2 sub-family...
- Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editingW Fang
Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA
Immunity 9:35-45. 1998..These studies suggest that Bcl-x may have a distinct role in controlling survival at the immature stage of B cell development and demonstrate that tolerance is preserved when self-reactive B cells escape central deletion...
- bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturationN Motoyama
Department of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
J Exp Med 189:1691-8. 1999..However, prominent cell death of bcl-x-/- EryP and EryD occurred when the cells matured. The data show that the antiapoptotic function of bcl-x acts at the very end of erythroid maturation...
- BCL-2 family members and the mitochondria in apoptosisA Gross
Department of Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 13:1899-911. 1999
- Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretionY P Zhou
Department of Medicine, Section of Endocrinology, University of Chicago, Chicago, Illinois 60637, USA
Am J Physiol Endocrinol Metab 278:E340-51. 2000....
- Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesisE B Rucker
Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Endocrinol 14:1038-52. 2000..These findings demonstrate that the balance of Bcl-x and Bax control PGC survival and apoptosis...
- Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegalyK U Wagner
Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bldg 8, Rm 107, Bethesda, MD 20892 0822, USA
Development 127:4949-58. 2000..Mice conditionally deficient in Bcl-x permitted us for the first time to study the effects of Bcl-x deficiency on cell proliferation, maturation and survival under physiological conditions in an adult animal...
- Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactationK D Walton
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Mech Dev 109:281-93. 2001..Concomitant deletion of the bax gene did not significantly modify the Bcl-x phenotype. Our results suggest that Bcl-x is not essential during mammopoiesis, but is critical for controlled apoptosis during the first phase of involution...
- Regulation of Bcl-xL expression by H2O2 in cardiac myocytesDonna M Valks
National Heart and Lung Institute Division Cardiac Medicine Section, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, United Kingdom
J Biol Chem 278:25542-7. 2003..These data demonstrate that the Bcl-x gene is selectively responsive to oxidative stress, and the response is mediated through distal promoter regions...
- BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosisNika N Danial
Howard Hughes Medical Institute, Dana Faber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 424:952-6. 2003..This combination of proteomics, genetics and physiology indicates an unanticipated role for BAD in integrating pathways of glucose metabolism and apoptosis...
- The structure of a Bcl-xL/Bim fragment complex: implications for Bim functionXinqi Liu
Howard Hughes Medical Institute, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Immunity 19:341-52. 2003..Our results suggest a way in which both Bim and Bax/Bak might be required for activated T cell apoptosis...
- Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosisJerry E Chipuk
Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
Science 303:1010-4. 2004..We propose that when p53 accumulates in the cytosol, it can function analogously to the BH3-only subset of proapoptotic Bcl-2 proteins to activate Bax and trigger apoptosis...
- Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimersSeon Yong Jeong
Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
EMBO J 23:2146-55. 2004..The C-terminal tail of Bcl-x(L) is also required to mediate Bcl-x(L)/Bax heterodimer formation. Both mitochondrial import and antiapoptotic activity of different Bcl-x(L) mutants correlate with their ability to form homodimers...
- Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cellsYanan Zhu
Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 101:7681-6. 2004..Our results indicate that, in T cells, Bim function is regulated by interaction with Bcl-2 family members on mitochondria rather than by sequestration to the microtubules...
- Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in miceWan Cheung Cheung
Cell Signaling Technology Inc, Beverly, Massachusetts, USA
J Clin Invest 113:1763-73. 2004..Our findings demonstrate that the enforced expression of Myc and Bcl-X(L) by Ig enhancers with peak activity in plasma cells generates a mouse model of human PCN that recapitulates some features of human multiple myeloma...
- bcl-xL is critical for dendritic cell survival in vivoHuiming Hon
Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA
J Immunol 173:4425-32. 2004..Taken together, our work demonstrates that the bcl-x(L) isoform is critical for survival of skin-derived, Ag-bearing DC in vivo...
- Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responsesTetsuo Takehara
Department of Molecular Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
Gastroenterology 127:1189-97. 2004..The aim of this study was to explore the function of Bcl-xL in hepatocytes using the Cre-loxP system and to analyze the consequences of long-term apoptosis in hepatocytes...
- Magnetic resonance diffusion tensor microimaging reveals a role for Bcl-x in brain development and homeostasisJiangyang Zhang
Department of Radiology, Division of Nuclear Magnetic Resonance Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 25:1881-8. 2005..Thus, this technique serves as a powerful tool to efficiently localize temporal and spatial manifestation of morphological phenotype...
- Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietinMelissa M Rhodes
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Blood 106:1857-63. 2005..Bcl-x(L) is not required for heme synthesis and does not mediate the antiapoptotic effects of erythropoietin, but it prevents ineffective erythropoiesis due to apoptosis in late-stage, hemoglobin-synthesizing erythroblasts...
- Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteinsSimon N Willis
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Genes Dev 19:1294-305. 2005..The finding that different prosurvival proteins have selective roles has notable implications for the design of anti-cancer drugs that target the Bcl-2 family...
- The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytesNu Zhang
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 174:6967-73. 2005..These results indicate that Bcl-x is dispensable for the generation of effector and memory T lymphocytes and suggest that costimulation of T lymphocytes promotes their survival through a Bcl-x(L) independent mechanism...
- A moderate reduction of Bcl-x(L) expression protects against tumorigenesis; however, it also increases susceptibility to tissue injuryCharles Christopher Henderson
Division of Urology, Washington University School of Medicine, Saint Louis, MO 63110, USA
Oncogene 24:7120-4. 2005..Additionally, they indicate that the potential for increased susceptibility to tissue injury must be considered in the design of chemopreventative and antineoplastic strategies that involve inhibition of Bcl-x(L) activity...
- Programmed anuclear cell death delimits platelet life spanKylie D Mason
Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Cell 128:1173-86. 2007....
- Participation of FLIP, RIP and Bcl-x(L) in Fas-mediated T-cell deathM Djerbi
Department of Immunology, The Wenner Gren Institute, University of Stockholm, Stockholm, Sweden
Scand J Immunol 66:410-21. 2007..These results indicate that yet uncharacterized signalling pathways from the Fas receptor are critically involved in lymphoproliferative and autoimmune disease observed in lpr mice and autoimmune lymphoproliferative syndrome patients...
- Dual role of proapoptotic BAD in insulin secretion and beta cell survivalNika N Danial
Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
Nat Med 14:144-53. 2008..Furthermore, we show that BAD regulates the physiologic adaptation of beta cell mass during high-fat feeding. Our findings provide genetic proof of the bifunctional activities of BAD in both beta cell survival and insulin secretion...
- Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancerJeffrey H Hager
Diabetes and Hellen Diller Family Comprehensive Cancer Centers, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 4:e4455. 2009....
- Bcl-x L increases mitochondrial fission, fusion, and biomass in neuronsSarah B Berman
W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
J Cell Biol 184:707-19. 2009..Deficits in these Bcl-x(L)-dependent mechanisms may be critical in neuronal dysfunction during the earliest phases of neurodegeneration, long before commitment to cell death...
- Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regressionBaohua Zhao
Department of Microbiology and Immunology and Pennsylvania State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Immunol 182:6744-52. 2009..The data provide new insights into why costimulatory signals might need to be sustained over time and suggest a potential novel approach to augment cellular immunotherapy for cancer...
- Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuliEmma M Carrington
Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
Diabetes 58:2316-23. 2009..We investigated the importance of Bcl-xL for beta-cells by deleting the Bcl-x gene specifically in beta-cells and analyzing their survival in vivo and in culture...
- Bcl-xL is required for the development of functional regulatory CD4 cells in lupus-afflicted mice following treatment with a tolerogenic peptideAmir Sharabi
The Weizmann Institute of Science, Rehovot 76100, Israel
J Autoimmun 34:87-95. 2010..We conclude that Bcl-xL is required for the development and function of CD4 Treg, which ameliorate lupus following treatment with a tolerogenic peptide...
- BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in plateletsTakahiro Kodama
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
J Biol Chem 286:13905-13. 2011..Despite residing in platelets, BH3-only activator proteins Bid and Bim are dispensable for Bax activation and mitochondrial apoptosis...
- Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survivalCaroline H Yi
Department of Cell Biology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Cell 146:607-20. 2011..We propose that acetyl-CoA serves as a signaling molecule that couples apoptotic sensitivity to metabolism by regulating protein N-alpha-acetylation...
- Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potentialYing bei Chen
Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
J Cell Biol 195:263-76. 2011..Thus, by bolstering mitochondrial energetic capacity, Bcl-x(L) may contribute importantly to cell survival independently of other Bcl-2 family proteins...
- bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic miceD A Grillot
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
J Exp Med 183:381-91. 1996..Induction of Bcl-xL after signaling through surface IgM and CD40 appears to provide mature B cells with an additional protective mechanism against apoptotic signals associated with antigen-induced activation and proliferation...
- Role of bcl-X(L) in the control of apoptosis in murine myeloma cellsE R Gauthier
Canadian Red Cross Blood Transfusion Service, Quebec, Canada
Cancer Res 56:1451-6. 1996..These results indicate a predominant role of bcl-X(L) in preventing apoptosis in myeloma cells and suggest that the expression of bcl-2 or bcl-X(L) genes in B-cell tumors depends on the differentiation stage of the precursor normal cell...
- BID: a novel BH3 domain-only death agonistK Wang
Department of Medicine and Pathology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genes Dev 10:2859-69. 1996..This BH3-only molecule supports BH3 as a death domain and favors a model in which BID represents a death ligand for the membrane-bound receptor BAX...
- Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XLJae Won Shim
Department of Biochemistry, College of Medicine, Hanyang University, Seoul 133 791, Korea
J Neurosci 24:843-52. 2004..These data suggest a role for Bcl-XL during in vitro midbrain DA neuron differentiation and provide an improved system for cell transplantation in a preclinical animal model of Parkinson's disease...
- Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosisYoshinori Takahashi
Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Mol Cell Biol 25:9369-82. 2005..Taken together, these findings support the notion that Bif-1 is an important component of the mitochondrial pathway for apoptosis as a novel Bax/Bak activator, and loss of this proapoptotic molecule may contribute to tumorigenesis...
- DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pHRui Zhao
Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge, United Kingdom
PLoS Biol 5:e1. 2007..Our findings also suggest novel approaches to cancer therapy...
- BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteinsChunyan Xu
Program on Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
J Biol Chem 283:11477-84. 2008..The findings reveal a hierarchy of functional interactions of BI-1 with Bcl-2/Bax family proteins in regulating ER Ca(2+) homeostasis...
- Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1Marc A Kerenyi
Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria
Blood 112:3878-88. 2008..Both genes were demonstrated to be direct transcriptional targets of Stat5. This establishes an unexpected mechanistic link between EpoR/Jak/Stat signaling and iron metabolism, processes absolutely essential for erythropoiesis and life...
- Expression of bcl-x during mouse B cell differentiation and following activation by various stimuliM S Choi
National Institute for Medical Research, London, GB
Eur J Immunol 26:676-82. 1996....
- A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cellsX F Yang
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Immunity 7:629-39. 1997..Identification of Bcl-x gamma helps provide a molecular explanation of T cell activation and death after antigen engagement...
- Expression of bcl-X(L) restores cell survival, but not proliferation off effector differentiation, in CD28-deficient T lymphocytesA M Dahl
Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 191:2031-8. 2000..These results indicate that the various functions of CD28 can be dissociated, and provide an experimental approach for testing the roles of downstream signals in the functions of cellular receptors such as CD28...
- FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis developmentRizwanul Haque
Department of Microbiology and Immunology and Penn State Hershey Cancer Institute, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Arthritis Res Ther 12:R66. 2010..In this study, we generated therapeutically active Tregs with an increased life span and hence greater therapeutic potential...
- Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activityShaynoor Dramsi
Department of Medicine, University of British Columbia and Vancouver Hospital, Jack Bell Research Centre, Vancouver, British Columbia, Canada, V6H 3Z6
J Biol Chem 277:6399-405. 2002..Similarly, the S112A/S170D double mutant does not cause apoptosis in HEK293 and MC/9 cell lines. These data strongly suggest that phosphorylation of Bad at Ser-170 is a critical event in blocking the pro-apoptotic activity of Bad...
- In vivo cooperation between Bcl-xL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosisJiro Umeda
Department of Dermatology, Osaka University Graduate School of Medicine, Japan
FASEB J 17:610-20. 2003..These results suggest that Bcl-xL and the PI3K-Akt pathway form a cooperative, intercompensatory axis for the protection of epidermal keratinocytes from apoptosis in vivo...
- A stapled BID BH3 helix directly binds and activates BAXLoren D Walensky
Department of Pediatric Oncology, Dana Farber Cancer Institute and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell 24:199-210. 2006..We further demonstrate that membrane targeting of stapled BID BH3 optimizes its ability to activate BAX, supporting a model in which BID directly engages BAX to trigger mitochondrial apoptosis...
- A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activityRaffaella Ponassi
Department of Oncology, University of Genoa, Genoa, Italy
Cell Cycle 7:3211-24. 2008..Altogether, these observations support the therapeutic potentials of this novel BH3 mimetic...
- A novel fluorescent-based assay reveals that thrombopoietin signaling and Bcl-X(L) influence, respectively, platelet and erythrocyte lifespansLucy A Coupland
The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
Exp Hematol 38:453-461.e1. 2010....
- Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-XlG Monaco
Laboratory of Molecular and Cellular Signaling, Department of Molecular Cell Biology, Campus Gasthuisberg O N 1 bus 802, Herestraat 49, BE 3000 Leuven, Belgium
Cell Death Differ 19:295-309. 2012..Mutating this residue affects the function of Bcl-2 in Ca(2+) signaling and apoptosis...
- BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cellsJeffrey M Harder
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Mol Cell Neurosci 51:53-9. 2012..Pro-survival family members such as BCL-X (BCL2L1) act to inhibit BAX activation...
- Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic targetJ G Harb
1 Human Cancer Genetics Program, Department Molecular Virology Immunology and Medical Genetics, Columbus, OH, USA 2 Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI, USA
Leukemia 27:1996-2005. 2013..Thus, suppression of the antiapoptotic potential of Bcl-xL together with BAD activation represents an effective pharmacological approach for patients undergoing blastic transformation. ..
- Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cellsPriyanka Sathe
1 The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia 2 Department of Medical Biology, University of Melbourne, Victoria 3010, Australia 3
Nat Commun 5:4539. 2014..These results clearly demonstrate a non-redundant pathway linking IL-15 to Mcl1 in the maintenance of NK cells and innate immune responses in vivo. ..
- Bcl-xL promotes metastasis independent of its anti-apoptotic activitySoyoung Choi
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York 10065, USA
Nat Commun 7:10384. 2016..Consistent with these findings, we detect nuclear Bcl-xL in human metastatic panNETs. Taken together, the metastatic function of Bcl-xL is independent of its anti-apoptotic activity and its residence in the mitochondria. ..
- Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activationJie Yan
Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
Cell 152:304-15. 2013..Our results reveal that IKK inhibits TNFα-induced apoptosis through two distinct but cooperative mechanisms: activation of the survival factor NF-κB and inactivation of the proapoptotic BH3-only BAD protein...
- Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degenerationR M Joseph
Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
Invest Ophthalmol Vis Sci 37:2434-46. 1996..To test the hypothesis that overexpression of genes coding for the anti-apoptotic proteins Bcl-2 or Bcl-XL in photoreceptor cells may prevent or delay photoreceptor degenerations...
- A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell deathR Carrio
Servicio de Inmunologia, H U Marqués de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
Am J Pathol 149:2133-42. 1996..Furthermore, its distribution in multiple tissues of the embryo suggests that A1 plays a role in the regulation of physiological cell death during embryonic development...
- Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cellsN Solvason
Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
J Exp Med 187:1081-91. 1998..Furthermore, our results link one of the immunodeficient traits caused by mutant Btk with the failure to properly regulate Bcl-xL...
- Expression of Bcl-2, Bcl-x, Mcl-1, Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopauseXuxia Wu
Section for Obstetrics and Gynecology, Department of Women s and Children s Health, Uppsala University, SE 751 85 Uppsala, Sweden
J Steroid Biochem Mol Biol 80:77-83. 2002..These proteins are suggested to interact with each other in the regulation of programmed cell death, apoptosis, but their specific role in growth control of uterine leiomyomas remains to be investigated...
- Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant miceGirish V Putcha
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
J Cell Biol 157:441-53. 2002..e., BID and BAD) do not contribute to BAX-dependent cyt c release or apoptosis caused by TFD...
- Cisplatin and TNF-alpha downregulate transcription of Bcl-xL in murine malignant mesothelioma cellsSimon A Fox
Pharmacogenetics Laboratory, School of Pharmacy, Curtin University of Technology and West Australian Biomedical Research Institute, Bentley, WA, Australia
Biochem Biophys Res Commun 337:983-91. 2005..The findings of the present study provide insights into apoptotic mechanisms in mesothelioma cells and show similar patterns of gene expression to that reported in the human disease...
- Stabilized beta-catenin extends thymocyte survival by up-regulating Bcl-xLHuimin Xie
Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
J Immunol 175:7981-8. 2005..beta-Catenin/TCF is thus able to act as a signal to up-regulate Bcl-xL levels in DP thymocytes, resulting in their enhanced survival...
- Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasionYi Chieh Nancy Du
Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
PLoS Biol 5:e276. 2007..In addition, myosin Va was identified as a novel Bcl-xL-interacting protein that might mediate the effects of Bcl-xL on tumor cell migration and invasion...
- AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangementsAlexander L Kovalchuk
Laboratory of Cancer Biology and Genetics, Cancer Genomics Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 204:2989-3001. 2007..In contrast, the second was T(12;15) negative, but had an elevated N-Myc expression caused by a paracentric inversion of chromosome 12. Thus, novel mechanisms juxtapose Ig and Myc-family genes in AID-deficient plasma cell tumors...
- Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitorsSefat E Khuda
Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 181:7537-49. 2008....
- The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in miceMitsuyasu Iwasawa
Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
J Clin Invest 119:3149-59. 2009....
- Stimulation of naive CD8+ T cells by a variant viral epitope induces activation and enhanced apoptosisRebecca M Ream
The Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 184:2401-9. 2010..This process of CD8(+) T cell activation, proliferation, and differentiation followed by rapid cell death may represent a novel mechanism of altered peptide ligand-induced apoptosis programmed by initial Ag receptor engagement...
- bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell deathM Gonzalez-Garcia
Department of Pathology and Anatomy, University of Michigan Medical School, Ann Arbor 48109, USA
Proc Natl Acad Sci U S A 92:4304-8. 1995..Thus, Bcl-x proteins appear to play an important role in the regulation of neuronal survival in the adult CNS...
- Bclx regulates the survival of double-positive thymocytesA Ma
Howard Hughes Medical Institute, Children s Hospital, Boston, MA, USA
Proc Natl Acad Sci U S A 92:4763-7. 1995The bclx gene has been shown to regulate programmed cell death in vitro...
- Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factorsG Middleton
School of Biological and Medical Sciences, University of St Andrews, Scotland
Development 122:695-701. 1996..Our results also argue that the relative amounts of Bcl-2 and Bax are critical in regulating neuronal survival...
- Chromosomal assignment of the Bcl2-related genes, Bcl2l and Bax, in the mouse and ratY Matsuda
Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan
Cytogenet Cell Genet 74:107-10. 1996The Bcl2-related genes, Bax and Bcl2l (formerly called Bclx), are involved in the regulation of apoptotic cell death, and the chromosome location of these two genes was determined in the mouse and rat by fluorescence in situ ..
- Spontaneous overexpression of the long form of the Bcl-X protein in a highly resistant P388 leukaemiaJ S Kuhl
Department of Medicine, Stanford University School of Medicine, CA 94305 5306, USA
Br J Cancer 75:268-74. 1997....
- Bcl-x expression influences keratinocyte cell survival but not terminal differentiationJ C Pena
Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA
Cell Growth Differ 8:619-29. 1997..Taken together, these findings demonstrate that although the terminal differentiation program is not altered by Bcl-x, acute stress responses within the skin can be influenced by regulators of apoptosis such as Bcl-x...
- Bcl-X is the major pleiotropic anti-apoptotic gene activated by retroviral insertion mutagenesis in an IL-3 dependent bone marrow derived cell lineJ Thomas
Immunologie Cellulaire, LBMC de L ENS Lyon, CNRS UMR49 INRA LA 913, France
Oncogene 16:1399-408. 1998..They also suggest that the Bcl-2 family of genes might be the only one capable of inhibiting apoptosis induced by multiple pathways without inducing cell proliferation...
- Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonistR Hegde
Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 273:7783-6. 1998..The apoptotic activity of Blk is also inhibited by a dominant negative caspase-9, suggesting that Blk induces apoptosis through activation of the cytochrome c-Apaf-1-caspase-9 pathway...
- A Bcl-xL transgene promotes malignant conversion of chemically initiated skin papillomasJ C Pena
Gwen Knapp Center for Lupus and Immunology Research, Committee on Immunology, University of Chicago, Illinois 60637, USA
Cancer Res 58:2111-6. 1998..In contrast, Bcl-xL overexpression can dramatically increase the malignant conversion rate of benign tumors, suggesting that inhibition of apoptosis can contribute to tumor progression...
- Bcl-2 family proteinsJ C Reed
The Burnham Institute, La Jolla, California 92037, USA
Oncogene 17:3225-36. 1998....
- Developmental expression patterns of Bcl-2, Bcl-x, Bax, and Bak in teethS Krajewski
The Burnham Institute formerly La Jolla Cancer Research Foundation, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell Death Differ 5:408-15. 1998....
- Bcl-2 & Branching MorphogenesisChristine Sorenson; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Dissecting the Death Pathway in the Islet beta-cellNika Danial; Fiscal Year: 2005..abstract_text> ..
- Targeting Apoptosis by Chemical DesignLOREN WALENSKY; Fiscal Year: 2007..Walensky's development as an independent investigator at the interface of these notable fields. ..
- BAD Intergrates Glycolysis and ApoptosisNika Danial; Fiscal Year: 2008..Danial's development as an independent investigator. Dr. Korsmeyer, a world leader in the fields of oncogenesis and apoptosis, has an excellent record of training and fostering independent investigators. ..