Bcat1

Summary

Gene Symbol: Bcat1
Description: branched chain aminotransferase 1, cytosolic
Alias: BCATc, Eca39, branched-chain-amino-acid aminotransferase, cytosolic, BCAT(c)
Species: mouse

Top Publications

  1. pmc Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle
    Pengxiang She
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cell Metab 6:181-94. 2007
  2. pmc Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover
    Christopher J Lynch
    Department of Cellular and Molecular Physiology, College of Medicine, Penn State University, Hershey, Pennsylvania
    Physiol Genomics 47:569-80. 2015
  3. pmc Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells
    Elitsa A Ananieva
    From the Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, Virginia 24061 and
    J Biol Chem 289:18793-804. 2014
  4. pmc Oral leucine supplementation is sensed by the brain but neither reduces food intake nor induces an anorectic pattern of gene expression in the hypothalamus
    Thais T Zampieri
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 8:e84094. 2013
  5. ncbi Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice
    Giacomo Manenti
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Oncogene 23:4495-504. 2004
  6. pmc ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease
    Jer Yuarn Wu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    J Clin Invest 113:434-40. 2004
  7. pmc Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion
    Yingsheng Zhou
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 285:33718-26. 2010
  8. ncbi Expression of cytosolic branched chain aminotransferase (BCATc) mRNA in the developing mouse brain
    Stefania Castellano
    Istituto di Neuroscienze del C N R, Pisa, Italy
    Gene Expr Patterns 7:485-90. 2007
  9. ncbi Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice
    Stefania Castellano
    Istituto di Neuroscienze del C N R, Via Moruzzi 1, 56100 Pisa, Italy
    Brain Res 1108:12-8. 2006
  10. ncbi An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence
    N Benvenisty
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115
    Genes Dev 6:2513-23. 1992

Research Grants

  1. REGULATION OF ADIPOCYTE PROTEIN SYNTHESIS BY AMINO ACIDS
    Christopher Lynch; Fiscal Year: 2007
  2. Role of Leucine Metabolism in Leucine Signaling
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2010

Scientific Experts

  • CHRISTOPHER JOHN LYNCH
  • Elitsa A Ananieva
  • Stefania Castellano
  • Pengxiang She
  • Thais T Zampieri
  • Giacomo Manenti
  • Yingsheng Zhou
  • Susan M Hutson
  • Yuri Bozzi
  • Pengyuan Liu
  • Jer Yuarn Wu
  • Federica Galbiati
  • Angela Pettinicchio
  • Tommaso A Dragani
  • Durvanei Augusto Maria
  • Christina H Grimm
  • N Benvenisty
  • João A B Pedroso
  • Isadora C Furigo
  • Julio Tirapegui
  • Jose Donato
  • T Ben-Yosef
  • S Weggen
  • Thomas L Jetton
  • Stephanie Goshorn
  • Tanya M Reid
  • Andras Hajnal
  • Andrew J Sweatt
  • Simona Casarosa
  • Thomas C Vary
  • Sarah K Bronson
  • Haris Vikis
  • Yan Lu
  • Daolong Wang
  • Manuela Scali
  • Yian Wang
  • Anna Maciag
  • Yan Liu
  • Francesca Macchi
  • Josh Z Huang
  • Ming You
  • Sing Chung Li
  • Hsiao Jung Kao
  • Steven Hillman
  • Roberto Gianni-Barrera
  • David Millington
  • A Eden
  • Yuan Tsong Chen
  • Robert Stevens
  • Abraham Acevedo
  • Roberto Giannì Barrera
  • Marcelo De Franco
  • Wafa Hanna Koury Cabrera
  • Olga Martinez Ibañez
  • Philip Avner
  • Orlando Garcia Ribeiro
  • Maria Siqueira
  • Nancy Starobinas
  • Ute C Rogner
  • O Schuldiner
  • I Ben-Porath
  • O D Wiestler
  • T A Bayer
  • N Hilger
  • I Klawitz
  • T Pietsch
  • K H Scheidtmann
  • U Preuss
  • S M Hutson
  • G Simchen
  • O Yanuka
  • R K Bledsoe
  • P A Dawson
  • T R Hall
  • A Kuo
  • A Leder
  • P Leder
  • O Niwa
  • T Kumazaki
  • K Yokoro
  • G Soma
  • T Tsukiyama
  • N Miyajima

Detail Information

Publications19

  1. pmc Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle
    Pengxiang She
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cell Metab 6:181-94. 2007
    ..These observations suggest that elevated BCAAs and/or loss of BCAA catabolism in peripheral tissues play an important role in regulating insulin sensitivity and energy expenditure...
  2. pmc Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover
    Christopher J Lynch
    Department of Cellular and Molecular Physiology, College of Medicine, Penn State University, Hershey, Pennsylvania
    Physiol Genomics 47:569-80. 2015
    ..The results suggest transcriptional adaptations occur in BCATm KO mice that along with altered nutrient signaling may contribute to their previously reported protein turnover, metabolic and exercise phenotypes. ..
  3. pmc Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells
    Elitsa A Ananieva
    From the Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, Virginia 24061 and
    J Biol Chem 289:18793-804. 2014
    Here we show that expression of the cytosolic branched chain aminotransferase (BCATc) is triggered by the T cell receptor (TCR) of CD4(+) T cells...
  4. pmc Oral leucine supplementation is sensed by the brain but neither reduces food intake nor induces an anorectic pattern of gene expression in the hypothalamus
    Thais T Zampieri
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 8:e84094. 2013
    ..the hypothalamic gene expression and observed that leucine supplementation increased the expression of enzymes (BCAT1, BCAT2 and BCKDK) that metabolize branched-chain amino acids...
  5. ncbi Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice
    Giacomo Manenti
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Oncogene 23:4495-504. 2004
    ..defined a core Pas1 haplotype with 42 tightly linked markers, including intragenic polymorphisms in five genes (Bcat1, Lrmp, Las1, Ghiso, and Kras2) and amino-acid changes in three genes (Lrmp, Las1, Lmna-rs1)...
  6. pmc ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease
    Jer Yuarn Wu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    J Clin Invest 113:434-40. 2004
    ..Metabolomics-guided screening, coupled with ENU mutagenesis, is a powerful approach in uncovering novel enzyme deficiencies and recognizing important pathways of genetic metabolic disorders...
  7. pmc Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion
    Yingsheng Zhou
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 285:33718-26. 2010
    ..Thus, KICSIS and LSIS occur by enhancing the metabolism of glutamine/glutamate to α-ketoglutarate, which, in turn, is metabolized to produce the intracellular signals such as ATP and NADPH for insulin secretion...
  8. ncbi Expression of cytosolic branched chain aminotransferase (BCATc) mRNA in the developing mouse brain
    Stefania Castellano
    Istituto di Neuroscienze del C N R, Pisa, Italy
    Gene Expr Patterns 7:485-90. 2007
    ..Two BCAT isoforms have been identified: one cytosolic (BCATc) and one mitochondrial (BCATm)...
  9. ncbi Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice
    Stefania Castellano
    Istituto di Neuroscienze del C N R, Via Moruzzi 1, 56100 Pisa, Italy
    Brain Res 1108:12-8. 2006
    ..BCAT exists in two isoforms: one cytosolic (BCATc), mainly expressed in the nervous system, and the other mitochondrial (BCATm), present in a greater number of ..
  10. ncbi An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence
    N Benvenisty
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115
    Genes Dev 6:2513-23. 1992
    ..This target gene encodes an anonymous cDNA (ECA39) found previously to be amplified in a teratocarcinoma cell line.
  11. ncbi Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6
    Christina H Grimm
    Unité de Génétique Moléculaire Murine, Institut Pasteur 25 rue du Docteur Roux, F 75724, Paris Cedex 15, France
    Autoimmunity 36:241-6. 2003
    ..which are implicated in the immune system and/or in the control of cell proliferation rates, such as Lrmp (Jaw1), Bcat1 and Kras2 that map to the Idd6 candidate region...
  12. ncbi Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response
    Durvanei Augusto Maria
    Laboratorio de Immunogenetica, Instituto Butantan, Sao Paulo, Brazil
    Oncogene 22:426-32. 2003
    ..These results provide a model to explore the mechanism underlying inherited predisposition to lung cancer in the context of a link to inflammation...
  13. ncbi Identification of amplified genes from SV40 large T antigen-induced rat PNET cell lines by subtractive cDNA analysis and radiation hybrid mapping
    S Weggen
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Oncogene 20:2023-31. 2001
    ..We propose that this simple cloning strategy may serve as a powerful tool for the isolation of genes implicated in known chromosomal aberrations in primary tumors and tumor cell lines...
  14. ncbi Characterization of murine BCAT genes: Bcat1, a c-Myc target, and its homolog, Bcat2
    T Ben-Yosef
    Department of Genetics, Hebrew University of Jerusalem, Israel
    Mamm Genome 9:595-7. 1998
  15. ncbi Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins
    I Ben-Porath
    Department of Genetics, Hebrew University of Jerusalem, Givat Ram, Israel
    Gene 183:69-75. 1996
    ..Thus, we present a novel family of membrane glycoproteins, one member of which is closely associated with proliferation and another with growth arrest...
  16. pmc ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast
    O Schuldiner
    Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Israel
    Proc Natl Acad Sci U S A 93:7143-8. 1996
    ..To further characterize the ECA39 gene, we set out to determine the evolutionary conservation of its regulatory and coding sequences...
  17. ncbi Cloning and expression of the mammalian cytosolic branched chain aminotransferase isoenzyme
    S M Hutson
    Department of Biochemistry, Wake Forest University Medical Center, Winston Salem, North Carolina 27157, USA
    J Biol Chem 270:30344-52. 1995
    ..BCAT, a yeast BCAT, which is hypothesized to be a mitochondrial form of the enzyme, and the murine BCATc (protein ECA39). Calculated molecular masses for the complete proteins are 33.9 kDa, 37.9 kDa, 42.9 kDa, and 43...
  18. pmc A cDNA clone overexpressed and amplified in a mouse teratocarcinoma line
    O Niwa
    Research Institute for Nuclear Medicine and Biology, Hiroshima University, Japan
    Nucleic Acids Res 18:6709. 1990
  19. ncbi Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
    Pengyuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 38:888-95. 2006
    ..Our findings demonstrate the prospects for using dense SNP maps in laboratory mice to refine previous QTL regions and identify genetic determinants of complex traits...

Research Grants2

  1. REGULATION OF ADIPOCYTE PROTEIN SYNTHESIS BY AMINO ACIDS
    Christopher Lynch; Fiscal Year: 2007
    ..The proposed studies will elucidate how leucine regulates mTOR and the roles of leucine stimulation of mTOR in adipose tissue physiology and obesity. ..
  2. Role of Leucine Metabolism in Leucine Signaling
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2010
    ..The implication of our ongoing research is that blocking the first step in BCAA metabolism with a drug, or to a less extent increasing dietary BCAAs, will promote weight loss. ..