Bap1

Summary

Gene Symbol: Bap1
Description: Brca1 associated protein 1
Alias: 2300006C11Rik, AA989761, AW553466, mKIAA0272, uch-x4, ubiquitin carboxyl-terminal hydrolase BAP1, BRCA1-associated protein 1, ubiquitin C-terminal hydrolase X4
Species: mouse

Top Publications

  1. pmc Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma
    Jinfei Xu
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Cancer Res 74:4388-97. 2014
  2. doi Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis
    Han Sae Lee
    Department of Life Science, The Research Center for Cellular Homeostasis, Ewha Womans University, 52 Ewhayeodae gil, Seodaemun gu, Seoul 120 750, Korea
    Nat Commun 5:5128. 2014
  3. pmc Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis
    Shan Shan Wang
    Hematology Oncology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 Departments of Developmental Biology, Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390
    Proc Natl Acad Sci U S A 111:16538-43. 2014
  4. pmc Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma
    A Napolitano
    University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA
    Oncogene 35:1996-2002. 2016
  5. pmc Loss of BAP1 function leads to EZH2-dependent transformation
    Lindsay M Lafave
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 21:1344-9. 2015
  6. pmc Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations
    Yuwaraj Kadariya
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Cancer Res 76:2836-44. 2016
  7. doi NeuCode Proteomics Reveals Bap1 Regulation of Metabolism
    Joshua M Baughman
    Department of Protein Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Cell Rep 16:583-95. 2016
  8. pmc Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1
    Shahram Misaghi
    Department of Physiological Chemistry, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Mol Cell Biol 29:2181-92. 2009
  9. pmc Loss of the tumor suppressor BAP1 causes myeloid transformation
    Anwesha Dey
    Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 337:1541-6. 2012
  10. ncbi BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
    D E Jensen
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Oncogene 16:1097-112. 1998

Detail Information

Publications10

  1. pmc Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma
    Jinfei Xu
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Cancer Res 74:4388-97. 2014
    ..Germline-inactivating mutations of BAP1 predispose to mesothelioma and certain other cancers...
  2. doi Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis
    Han Sae Lee
    Department of Life Science, The Research Center for Cellular Homeostasis, Ewha Womans University, 52 Ewhayeodae gil, Seodaemun gu, Seoul 120 750, Korea
    Nat Commun 5:5128. 2014
    ..is recruited to replication forks through interaction with ubiquitinated H2A--aided by BRCA1-associated protein-1 (BAP1), a tumour suppressor and nuclear de-ubiquitinating enzyme that also functions to stabilize Ino80...
  3. pmc Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis
    Shan Shan Wang
    Hematology Oncology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 Departments of Developmental Biology, Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390
    Proc Natl Acad Sci U S A 111:16538-43. 2014
    ..Chromosome 3p harbors several additional tumor suppressor genes, including BRCA1-associated protein-1 (BAP1). In the mouse, Vhl is on a different chromosome than Bap1...
  4. pmc Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma
    A Napolitano
    University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA
    Oncogene 35:1996-2002. 2016
    Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with professional exposure to asbestos...
  5. pmc Loss of BAP1 function leads to EZH2-dependent transformation
    Lindsay M Lafave
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 21:1344-9. 2015
    The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub)...
  6. pmc Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations
    Yuwaraj Kadariya
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Cancer Res 76:2836-44. 2016
    Individuals harboring inherited heterozygous germline mutations in BAP1 are predisposed to a range of benign and malignant tumor types, including malignant mesothelioma, melanoma, and kidney carcinoma...
  7. doi NeuCode Proteomics Reveals Bap1 Regulation of Metabolism
    Joshua M Baughman
    Department of Protein Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Cell Rep 16:583-95. 2016
    ..Using NeuCode, we characterize an inducible knockout mouse model of Bap1, a tumor suppressor and deubiquitinase whose in vivo roles outside of cancer are not well established...
  8. pmc Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1
    Shahram Misaghi
    Department of Physiological Chemistry, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Mol Cell Biol 29:2181-92. 2009
    ..BRCA1-associated protein-1 (Bap1) is a ubiquitin carboxy-terminal hydrolase and is frequently mutated in lung and sporadic breast tumors...
  9. pmc Loss of the tumor suppressor BAP1 causes myeloid transformation
    Anwesha Dey
    Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 337:1541-6. 2012
    De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies...
  10. ncbi BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
    D E Jensen
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Oncogene 16:1097-112. 1998
    We have identified a novel protein, BAP1, which binds to the RING finger domain of the Breast/Ovarian Cancer Susceptibility Gene product, BRCA1...