B7 1

Summary

Gene Symbol: B7 1
Description: CD80 antigen
Alias: B71, Cd28l, Ly-53, Ly53, MIC17, TSA1, T-lymphocyte activation antigen CD80, B7 protein, activation B7-1 antigen
Species: mouse

Top Publications

  1. ncbi Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice
    L Van Parijs
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 159:5336-44. 1997
  2. ncbi Simultaneous expression of allogenic class II MHC and B7.1 (CD80) molecules in A20 B-lymphoma cell line enhances tumor immunogenicity
    Young Ju Jang
    Department of Microbiology, College of Medicine, Hanyang University, Seoul, Korea
    Mol Cells 13:130-6. 2002
  3. pmc Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    Manish J Butte
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 27:111-22. 2007
  4. ncbi Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse
    S Wong
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011
    Diabetes 44:326-9. 1995
  5. pmc B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function
    MELANIE A RUFFNER
    Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Eur J Immunol 39:3084-90. 2009
  6. ncbi Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice
    E Gärdby
    Department of Medical Microbiology and Immunology, University of Goteborg, Sweden
    J Immunol 161:49-59. 1998
  7. ncbi Acquisition of CD80 (B7-1) by T cells
    H Sabzevari
    Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:2505-13. 2001
  8. ncbi Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice
    Wolfram Karges
    Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany
    Diabetes 51:3237-44. 2002
  9. pmc Induction of B7-1 in podocytes is associated with nephrotic syndrome
    Jochen Reiser
    Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 113:1390-7. 2004
  10. ncbi The mechanism of exogenous B7.1-enhanced IL-12-mediated complete regression of tumors by a single electroporation delivery
    Jianguo Liu
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Int J Cancer 119:2113-8. 2006

Scientific Experts

Detail Information

Publications146 found, 100 shown here

  1. ncbi Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice
    L Van Parijs
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 159:5336-44. 1997
    ..Therefore, functionally significant levels of B7 expressed constitutively on mature lymphocytes are not, by themselves, sufficient to abrogate T cell tolerance or induce autoimmune disease...
  2. ncbi Simultaneous expression of allogenic class II MHC and B7.1 (CD80) molecules in A20 B-lymphoma cell line enhances tumor immunogenicity
    Young Ju Jang
    Department of Microbiology, College of Medicine, Hanyang University, Seoul, Korea
    Mol Cells 13:130-6. 2002
    ..1 for their efficacy as preventive tumor vaccines in vivo. The results indicate that the A20 cells that express both the I-Ab and B7.1 have more potent vaccinating potential, compared to the cells that express only one of the molecules...
  3. pmc Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    Manish J Butte
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 27:111-22. 2007
    ..Our findings point to a substantial bidirectional inhibitory interaction between B7-1 and PD-L1 and add an additional dimension to immunoregulatory functions of the B7:CD28 family...
  4. ncbi Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse
    S Wong
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011
    Diabetes 44:326-9. 1995
    ..This illustrates that B7-1 is a very potent co-stimulatory molecule in vivo and that its presence on the surface of tissue cells can potentiate the autoimmune process...
  5. pmc B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function
    MELANIE A RUFFNER
    Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Eur J Immunol 39:3084-90. 2009
    ..We conclude that B7-1 and B7-2, but not PD-L1 and PD-L2, on IL-10-treated DC and DC-derived exosomes play a critical role in immunosuppressive functions of both DC and exosomes...
  6. ncbi Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice
    E Gärdby
    Department of Medical Microbiology and Immunology, University of Goteborg, Sweden
    J Immunol 161:49-59. 1998
    ..This study reveals a paradox in the regulation of mucosal IgA responses...
  7. ncbi Acquisition of CD80 (B7-1) by T cells
    H Sabzevari
    Laboratory of Tumor Immunology and Biology, Division of Basic Sciences, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:2505-13. 2001
    ..Thus we demonstrate both immunostimulatory and immunoregulatory functions as a result of CD80 acquisition by different T cell populations...
  8. ncbi Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice
    Wolfram Karges
    Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany
    Diabetes 51:3237-44. 2002
    ..In antigen-based prevention of type 1 diabetes, diabetes acceleration should be considered as a potential adverse result...
  9. pmc Induction of B7-1 in podocytes is associated with nephrotic syndrome
    Jochen Reiser
    Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 113:1390-7. 2004
    ..Our findings suggest a novel function for B7-1 in danger signaling by nonimmune cells...
  10. ncbi The mechanism of exogenous B7.1-enhanced IL-12-mediated complete regression of tumors by a single electroporation delivery
    Jianguo Liu
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Int J Cancer 119:2113-8. 2006
    ..1 expression. We therefore propose a 2-signal stimulation model to explain the synergistic effect of the coadministration of IL-12 and B7.1 on the regression of the tumors...
  11. ncbi Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1
    Justine D Mintern
    Department of Pathology, Harvard Medical School, Boston, MA 02115 USA
    J Immunol 177:8422-31. 2006
    ..These results show a novel function for m138 in MCMV infection and identify the first viral protein to target B7-1...
  12. doi B-1 cell-derived monoclonal antibodies and costimulatory molecules
    Juyoun Lee
    Department of Periodontology, School of Dentistry, Pusan National University and Medical Research Institute, Pusan National University, Seo Ku, Pusan, Korea
    J Surg Res 154:293-8. 2009
    ..1 and B7.2) by splenic and peritoneum-derived (PerC) B cells to a different antigenic stimulation...
  13. ncbi Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen
    Y Liu
    Section of Immunobiology, Yale University School of Medicine, New Haven
    Eur J Immunol 22:2855-9. 1992
    ..These results demonstrate that functionally defined co-stimulation involves at least B7 and HSA and suggest that signals delivered by B7 and HSA synergize in promoting T cell growth...
  14. pmc T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
    P S Linsley
    Oncogen, Seattle, WA 98121
    Proc Natl Acad Sci U S A 87:5031-5. 1990
    ....
  15. ncbi The B7 and CD28 receptor families
    C H June
    Immune Cell Biology Program, Naval Medical Research Institute, Bethesda, MD
    Immunol Today 15:321-31. 1994
    ..Here, Carl June and colleagues highlight recent advances in the understanding of the CD28 and B7 receptor families...
  16. pmc Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
    W W Hancock
    Department of Pathology, New England Deaconess Hospital, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 93:13967-72. 1996
    ..These data also suggest that long-term graft survival can be achieved without blockade of either T cell receptor-mediated signals or CD28-CD86 engagement...
  17. ncbi B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
    F Borriello
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Immunity 6:303-13. 1997
    ..Thus, B7-2 has an important role in initiating antibody responses in the absence of adjuvant, but the induction of B7-1 by adjuvant in B7-2-deficient mice can compensate for the absence of B7-2...
  18. ncbi Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production
    A N Schweitzer
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 161:2762-71. 1998
    ....
  19. ncbi A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade
    A M Girvin
    Department of Microbiology Immunology, Northwestern University Medical School, Northwestern University Institute for Neuroscience, Chicago, IL 60611, USA
    J Immunol 164:136-43. 2000
    ..Collectively, these results support a critical role for CD28 costimulation in EAE induction...
  20. ncbi B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    B Salomon
    Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Illinois 60637, USA
    Immunity 12:431-40. 2000
    ..The results suggest that the CD28/ B7 costimulatory pathway is essential for the development and homeostasis of regulatory T cells that control spontaneous autoimmune diseases...
  21. pmc Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    G J Freeman
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1027-34. 2000
    ..PD-L1 expression on nonlymphoid tissues and its potential interaction with PD-1 may subsequently determine the extent of immune responses at sites of inflammation...
  22. pmc B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4
    D A Mandelbrot
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 107:881-7. 2001
    ..Finally, administration of CTLA4-Ig to CD28/CTLA4(-/-) cardiac allograft recipients significantly prolongs graft survival. These data support the existence of an additional receptor for B7 molecules that is neither CD28 nor CTLA4...
  23. ncbi In vivo CD86 blockade inhibits CD4+ T cell activation, whereas CD80 blockade potentiates CD8+ T cell activation and CTL effector function
    Thomas J Lang
    Research Service, Baltimore Veterans Affairs Medical Center, and Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 168:3786-92. 2002
    ..In contrast, CD86 is critical for the activation of naive CD4(+) T cells in either a Th1 or a Th2 cytokine-mediated response...
  24. pmc Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells
    Jian Xin Gao
    Department of Pathology and Comprehensive Cancer Center, Division of Cancer Immunology, Ohio State University Medical Center, Columbus, OH 43210, USA
    J Exp Med 195:959-71. 2002
    ..The strong pathogenicity of the self-reactive T cells supports a central hypothesis in immunology, which is that clonal deletion plays an important role in preventing autoimmune diseases...
  25. ncbi Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion
    Daniel Kreisel
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Immunol 169:6154-61. 2002
    ..These results suggest that vascular endothelium can act as an APC for CD8(+) direct allorecognition and may, therefore, play an important role in regulating immune processes of allograft rejection...
  26. ncbi In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis
    Aurore Saudemont
    Unite Inserm 524, Institut de Recherche sur le Cancer de Lille, Lille, France
    Blood 104:2124-33. 2004
    ..Thus, escape of leukemic cells from tumor immunity via overexpression of B7-H1 or B7.1 might represent a new mechanism of tumor dormancy in acute leukemia...
  27. ncbi CD80/CD86 costimulation regulates acute vascular rejection
    Karoline A Hosiawa
    Division of Experimental Therapeutics, University Health Network, Toronto General Research Institute, Toronto General Hospital, Toronto, Ontario, Canada
    J Immunol 175:6197-204. 2005
    ..Most strikingly, indefinite xenograft survival can be achieved by suppressing AVR with CD86 neutralization in combination of CsA therapy, which inhibits CMR...
  28. ncbi CD4(+) T cells stimulate memory CD8(+) T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion
    Meiqing Shi
    Saskatchewan Cancer Agency, Department of Microbiology and Immunology, College of Medicine, University of Saskatchewan, 20 Campus Dr, Saskatoon S7N 4H4, Canada
    J Leukoc Biol 80:1354-63. 2006
    ..These results highlight a previously undescribed role of active CD4(+) T cells in triggering expansion of memory CD8(+) T cells...
  29. ncbi Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis
    Shannon K O'Neill
    Department of Immunology Microbiology, Rush University, Medical Center, Chicago, IL 60612, USA
    J Immunol 179:5109-16. 2007
    ..These results demonstrate that a CD80/86:CD28 costimulatory interaction between B cells and T cells is required for autoreactive T cell activation and the induction of arthritis but not for B cell autoantibody production...
  30. pmc CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis
    Anna Nolan
    Oregon Health and Science University, Division of Pulmonary and Critical Care, Mail Code UHN67, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Am J Respir Crit Care Med 177:301-8. 2008
    ..Studies from our group and others suggest a potentially important role for these costimulatory cascades in innate immunity as well...
  31. pmc CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
    Randall H Friedline
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Exp Med 206:421-34. 2009
    ..These results demonstrate that CTLA-4 is absolutely required for FOXP3(+) regulatory T cell function in vivo...
  32. pmc Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation
    Sumeena Bhatia
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:1821-8. 2010
    ..These events regulate signaling through TCR/CD28 to maximize T cell activation to proliferation...
  33. pmc Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension
    Antony Vinh
    Cardiology Division, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Circulation 122:2529-37. 2010
    ..The latter often involves interaction between B7 ligands (CD80 and CD86) on antigen-presenting cells with the T-cell coreceptor CD28. This study was therefore performed to examine the role of this pathway in hypertension...
  34. pmc Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
    Omar S Qureshi
    Medical Research Council MRC Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham B15 2TT, UK
    Science 332:600-3. 2011
    ....
  35. pmc CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation
    Kim L Good-Jacobson
    Department of Laboratory Medicine, Yale University, New Haven, CT 06519, USA
    J Immunol 188:4217-25. 2012
    ..This, in turn, results in impaired ability to produce long-lived PCs. These data provide new insights into the development of GCs and Ab-forming cells and the functions of CD80 in humoral immunity...
  36. ncbi Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice
    G J Freeman
    Division of Hematologic Malignancies, Dana Farber Cancer Institute, Boston, MA
    Science 262:907-9. 1993
    ..These receptors are functionally important because the residual allogenic mixed lymphocyte responses were blocked by CTLA4Ig. Characterization of these CTLA-4 ligands should lead to strategies for manipulating the immune response...
  37. pmc Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis
    T T Chang
    Immunology Research Division, Department of Pathology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 190:733-40. 1999
    ....
  38. ncbi The role of B7 costimulation in CD4/CD8 T cell homeostasis
    X Yu
    Experimental Immunology Branch, National Cancer Institute, and National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:3543-53. 2000
    ..These reciprocal effects of genetically engineered increase or decrease in B7 expression indicate that B7 costimulation plays a physiological role in the regulation of CD4+ and CD8+ T cell homeostasis...
  39. ncbi B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections]
    Patricia A Taylor
    Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, University of Minnesota, 425 East River Road, Minneapolis, MN 55455, USA
    J Immunol 172:34-9. 2004
    ..The up-regulation of B7 on T cells may be an important component of normal immune homeostasis...
  40. pmc Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
    Silke Paust
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, 44 Binney Street, SM 722, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:10398-403. 2004
    ..Because expression of these B7 truncation mutants restores CD28-dependent costimulatory activity, these findings that indicate B7-based transmission of suppressive activity suggest new approaches to modifying autoimmune responses...
  41. ncbi Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5
    F Borriello
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115
    J Immunol 153:5038-48. 1994
    ..In addition, we report the chromosomal location of mB7-1 to chromosome 16, band B5...
  42. ncbi Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation
    M R Prabhu Das
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115
    Eur J Immunol 25:207-11. 1995
    ..This pattern of expression of B7-1 and B7-2 on T cells suggests that these two molecules may have different roles in the generation and regulation of immune responses...
  43. ncbi Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro
    T F Gajewski
    Ludwig Institute for Cancer Research, Brussels Branch, Belgium
    J Immunol 154:5637-48. 1995
    ....
  44. pmc Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4
    C A Fargeas
    Laboratoire d Immunologie, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    J Exp Med 182:667-75. 1995
    ..One of these residues, Y87, is conserved in all CD80 and CD86 cloned from various species. These results being to unravel the structural requirements for binding to CD28 and CTLA4...
  45. pmc Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1
    R J Peach
    Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
    J Exp Med 180:2049-58. 1994
    ..Thus, the MYPPPY motifs of CTLA4Ig and CD28Ig are important for their binding to B7-1, but the increased strength of this binding by CTLA4Ig is mediated by nonconserved residues in the CDR1- and CDR3-analogous regions...
  46. pmc Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1
    P Lane
    Basal Institute for Immunology, Switzerland
    Immunology 80:56-61. 1993
    ..These findings are discussed in the light of the physiological activation of T cells in secondary lymphoid organs...
  47. ncbi Interferon-gamma and interleukin-10 inhibit antigen presentation by Langerhans cells for T helper type 1 cells by suppressing their CD80 (B7-1) expression
    H Ozawa
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Immunol 26:648-52. 1996
    ..The inhibitory effect of IFN-gamma on CD80 expression on LC appears to be partially mediated through the suppression of GM-CSF production by KC...
  48. ncbi Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma
    C C Leong
    Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, Nedlands
    Int J Cancer 71:476-82. 1997
    ..Our observations are relevant to human MM because these cell lines have been derived from asbestos-induced tumors and share many properties with human cell lines of the same histological type...
  49. ncbi The role of donor and recipient B7-1 (CD80) in allograft rejection
    X X Zheng
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 159:1169-73. 1997
    ..These data also indicate that B7-1 and B7-2 are the only CD28 ligands relevant to cardiac allograft rejection in mice...
  50. ncbi The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3
    R H Reeves
    Department of Physiology, 202 Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Mamm Genome 8:581-2. 1997
  51. ncbi In vivo immunogenicity of osteosarcoma cells that express B7-1a, an alternatively spliced form of B7-1
    Masashi Nagamori
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Japan
    Anticancer Res 22:2009-13. 2002
    ..B7 family members play a central costimulatory role in T cell activation. We have previously identified B7-1a, an alternatively spliced form of B7-1. The function of B7-1a in induction of anti-tumor immunity remains uncertain...
  52. ncbi A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection
    Janet E Buhlmann
    Department of Pathology, Immunology Research Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:5421-8. 2003
    ..Finally, CTLA-4 delivers signals that inhibit selection, suggesting that CTLA-4 and CD28 have opposing functions in thymic development. Combined, the data demonstrate that B7-1/B7-2-dependent signals help shape the T cell repertoire...
  53. pmc Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor
    Tahiro Shin
    Sidneu Kimmel Comprehensive Cancer Centre, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Exp Med 198:31-8. 2003
    ..Finally, costimulation with B7-DC alone or in conjunction with B7-1 is PD-1 independent, indicating that B7-DC costimulates T cells via a second receptor...
  54. ncbi B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice
    Chiara Buono
    Immunology Research Division and the Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 109:2009-15. 2004
    ..This study tested the hypothesis that the ability of T cells to influence atherosclerosis depends on B7-1/B7-2 costimulation...
  55. ncbi Expression and functional analysis of murine B7 delineated by a novel monoclonal antibody
    G D Powers
    Roche Research Center, Nutley, New Jersey 07110
    Cell Immunol 153:298-311. 1994
    ....
  56. ncbi Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells
    C P Larsen
    Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322
    J Immunol 152:5208-19. 1994
    ....
  57. ncbi IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2
    R M Stack
    Committee on Developmental Biology, University of Chicago, IL 60637
    J Immunol 152:5723-33. 1994
    ..Additionally, these findings support our previous findings that an alternative ligand for CD28 and CTLA4 is important in providing costimulation...
  58. pmc Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function
    K S Hathcock
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Exp Med 180:631-40. 1994
    ..Moreover, expression of B7-1 and B7-2 can be independently regulated by the same stimulus, providing an additional complexity in the mechanisms available for regulating costimulation and hence immune response...
  59. ncbi Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen
    D J Lenschow
    Committee on Immunology, University of Chicago, IL 60637
    J Immunol 153:1990-7. 1994
    ..Thus, the effectiveness of Ag-specific B cells as APCs depends on both their enhanced Ag uptake, mediated by the B cell receptor, and immediate up-regulation of a potent costimulatory molecule, B7-2...
  60. ncbi Cloning and sequencing of the rabbit gene encoding T-cell costimulatory molecules
    T Isono
    Immunogenetics 42:217-20. 1995
  61. ncbi Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function
    I Kariv
    Department of Molecular Immunology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    J Immunol 157:29-38. 1996
    ..Furthermore, for CD28, the strength of functional response, as measured by IL-2 production, directly correlates with binding avidity...
  62. ncbi The role of CTLA-4 in regulating Th2 differentiation
    M A Oosterwegel
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 163:2634-9. 1999
    ..Thus, the B7-CD28/CTLA-4 pathway plays a critical role in regulating Th2 differentiation in two ways: CD28 promotes Th2 differentiation while CTLA-4 limits Th2 differentiation...
  63. ncbi B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness
    D A Mark
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 22:265-71. 2000
    ..Our observations suggest that whereas B7-2 is quantitatively more significant in the induction of this response, B7-1 and B7-2 may have complementary roles in mediating the development of allergic pulmonary inflammation...
  64. ncbi Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice
    K Kinoshita
    Laboratory of Molecular Autoimmune Disease, Renal Division, Department of Medicine, Center for Neurological Disease, and Immunology Research Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 164:6046-56. 2000
    ..Our findings demonstrate that B7-1 and B7-2 costimulatory pathways are critical to the pathogenesis of autoimmune lupus...
  65. ncbi Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus
    B Liang
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 165:3436-43. 2000
    ..By comparison, B7-1-deficient MRL-lpr/lpr mice had more severe IgG and C3 deposits in glomeruli...
  66. ncbi B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans
    Claudia Montagnoli
    Microbiology Section, Department of Experimental Medicine and Biochemical Science, University of Perugia, Italy
    J Immunol 169:6298-308. 2002
    ..The implication is that preventing reactivation rather than favoring sterilizing immunity to ubiquitous fungal pathogens may represent the ultimate expectation of vaccine-based strategies...
  67. ncbi Up-regulation of CD80-CD86 and IgA on mouse peritoneal B-1 cells by porin of Shigella dysenteriae is Toll-like receptors 2 and 6 dependent
    Avijit Ray
    Division of Immunology and Vaccine Development, National Institute of Cholera and Enteric Diseases, P 33, C I T Road, Scheme XM, Kolkata 700010, West Bengal, India
    Mol Immunol 41:1167-75. 2004
    ..4- and 2.6-fold, respectively. The IgA expressed on both B-1a and B-1b cell surfaces after 72 h of culture was found to bind to the 38 kDa monomer of porin confirming it to be anti-porin IgA antibody...
  68. ncbi CD80 binding polyproline helical peptide inhibits T cell activation
    Mythily Srinivasan
    Department of Oral Pathology, School of Dentistry, 1121 W Michigan St, Indianapolis 46202, USA
    J Biol Chem 280:10149-55. 2005
    ..Structural and functional studies suggest potential therapeutic value for select CD80 competitive antagonist peptides...
  69. ncbi CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms
    Dragana Odobasic
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia
    Kidney Int 68:584-94. 2005
    ..The aim of the current studies was to define the mechanisms by which CD80 and CD86 regulate the development of this disease...
  70. ncbi Induction of immunological antitumor effects by adenovirus-mediated gene transfer of B7-1 in a murine squamous cell carcinoma cell line
    Yasuhiko Hoshitani
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, International Center for Medical Research and Treatment, School of Medicine, Kobe University, Kobe, Japan
    Arch Otolaryngol Head Neck Surg 133:270-5. 2007
    ..Transfection of the costimulatory molecule B7-1 gene into certain murine tumors increases antitumor immunity and suppresses tumor growth...
  71. ncbi Lentiviral gene transfer of CTLA4 generates B cells with reduced costimulatory properties
    B Vogt
    Genethor GmbH, Goltz Strasse 52, 10781, Berlin, Germany
    Autoimmunity 42:380-2. 2009
    ..We show that B cells with reduced B7 expression reduce the antigen (Ag) specific TC proliferation in vitro. B cells expressing an ER-directed CTLA4 may reduce Ag-specific immune responses...
  72. pmc Alveolar macrophages stimulate enhanced cytokine production by pulmonary CD4+ T-lymphocytes in an exacerbation of murine chronic asthma
    Cristan Herbert
    Inflammation and Infection Research Centre, Schoolof Medical Sciences, University of New South Wales, Sydney, Australia
    Am J Pathol 177:1657-64. 2010
    ..We conclude that in an acute exacerbation of asthma, enhanced cytokine expression by AM may play a critical role in triggering increased expression of cytokines by pulmonary CD4(+) T-lymphocytes...
  73. pmc Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells
    S Peter Bak
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Immunol 189:1708-16. 2012
    ..These findings reveal dynamic requirements for costimulatory signals to overcome tumor-induced tolerance and have significant implications for developing more effective cancer immunotherapies...
  74. pmc CD154 and IL-2 signaling of CD4+ T cells play a critical role in multiple phases of CD8+ CTL responses following adenovirus vaccination
    Channakeshava Sokke Umeshappa
    Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    PLoS ONE 7:e47004. 2012
    ....
  75. pmc Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla
    Magali Irla
    Department of Pathology and Immunology, University of Geneva Medical School, Geneva, Switzerland
    PLoS ONE 7:e52591. 2012
    ..Our results show that Ag-dependent interactions between autoreactive CD4⁺ thymocytes and mTECs fine-tune homeostasis of the medulla by completing the signaling axes implicated in mTEC expansion and medullary organization...
  76. pmc Cbx4 regulates the proliferation of thymic epithelial cells and thymus function
    Bo Liu
    Department of Immunology and Key Laboratory of Medical Immunology of Ministry of Public Health, Peking University Health Science Center, Beijing 100191, China
    Development 140:780-8. 2013
    ..Together, these data establish Cbx4 as a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development...
  77. pmc Sex-associated expression of co-stimulatory molecules CD80, CD86, and accessory molecules, PDL-1, PDL-2 and MHC-II, in F480+ macrophages during murine cysticercosis
    Cristián Togno-Peirce
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, AP 70228, 04510 Mexico, DF, Mexico
    Biomed Res Int 2013:570158. 2013
    ..These findings suggest that macrophage recruitment at early time points during T. crassiceps infection is a possible mechanism that underlies the differential sex-associated susceptibility displayed by the mouse gender...
  78. doi Natural regulatory T cells limit angiotensin II-induced aneurysm formation and rupture in mice
    Hafid Ait-Oufella
    From the Institut National de la Santé et de la Recherche Médicale INSERM, Unit 970, Paris Cardiovascular Research Center, Universite Paris Descartes, Paris, France H A O, Y W, O H, S B, S P, J J, X L, P P, B E, M D, L L, A T, Z M Service de Réanimation Médicale, Hopital Saint Antoine, Universite Pierre et Marie Curie, Paris, France H A O and Division of Cardiovascular Medicine, Department of Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom Z M
    Arterioscler Thromb Vasc Biol 33:2374-9. 2013
    ....
  79. doi Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation
    Antonios Chatzigeorgiou
    Department of Clinical Pathobiochemistry, Technische Universitat Dresden, Dresden, Germany Institute for Clinical Chemistry and Laboratory Medicine, Technische Universitat Dresden, Dresden, Germany Department of Medicine III, Technische Universitat Dresden, Dresden, Germany Paul Langerhans Institute, Dresden, Dresden, Germany
    Hepatology 60:1196-210. 2014
    ..Antibody-blockade of both B7.1 and B7.2 improved the metabolic phenotype of DIO mice, which was linked to amelioration of hepatic steatosis and reduced inflammation in liver and AT...
  80. pmc CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype
    Griselda V Zuccarino-Catania
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 15:631-7. 2014
    ..The gene-expression patterns of the subsets supported both the identity and function of these distinct MBC types. Hence, the differentiation and regeneration of MBCs are compartmentalized...
  81. pmc CD28-CD80 interactions control regulatory T cell motility and immunological synapse formation
    Timothy J Thauland
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239
    J Immunol 193:5894-903. 2014
    ..Taken together, these results support the hypothesis that Tregs are tuned to alter their motility depending on costimulatory signals. ..
  82. ncbi Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells
    Elham Beyranvand Nejad
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 76:6017-6029. 2016
    ..Cancer Res; 76(20); 6017-29. ©2016 AACR...
  83. ncbi CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells
    Rongcun Yang
    Department of Immunology, College of Medicine, Nankai University, Tianjin, China
    Cancer Res 66:6807-15. 2006
    ..Thus, CD80-dependent responses to myeloid suppressor cells may contribute to tumor tolerance and the progression of ovarian carcinoma...
  84. pmc Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus
    Eulogia Roman
    Department of Immunology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 185:3819-23. 2010
    ..In addition, Treg selection requires the TCR signal and CD28 costimulation presented in cis on the same APC type in vivo. This study demonstrates a new role, to our knowledge, for HCs in the development of Tregs in thymus...
  85. doi Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation
    Liat Bar-On
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Eur J Immunol 41:291-8. 2011
    ....
  86. pmc Trogocytosis of CD80 and CD86 by induced regulatory T cells
    Peng Gu
    University of Toronto Transplant Institute, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Cell Mol Immunol 9:136-46. 2012
    ..These findings provide novel understanding of the interaction between iTregs and DCs, suggesting that trogocytosis may play a significant role in iTreg-mediated immune suppression...
  87. doi Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity
    Shirley G K Seah
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Eur J Immunol 42:1744-54. 2012
    ..We suggest that direct CD28 costimulation of CD8(+) T cells is more critical in their priming during primary influenza infection than previously appreciated...
  88. pmc Mcl-1 is essential for the survival of plasma cells
    Victor Peperzak
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Immunol 14:290-7. 2013
    ..Our results identify a critical role for Mcl-1 in the maintenance of plasma cells...
  89. ncbi Dysregulated B7-1 and B7-2 expression on nonobese diabetic mouse B cells is associated with increased T cell costimulation and the development of insulitis
    Shabbir Hussain
    Autoimmunity Diabetes Group, Robarts Research Institute, University of Western Ontario, London, Canada
    J Immunol 174:680-7. 2005
    ..These results suggest that increased B7-1 and B7-2 expression on islet-infiltrated NOD B cells is associated with increased T cell costimulation and the development of inflammatory insulitis in NOD mice...
  90. pmc Different cell surface oligomeric states of B7-1 and B7-2: implications for signaling
    Sumeena Bhatia
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 102:15569-74. 2005
    ....
  91. doi Cutting edge: CD28 engagement releases antigen-activated invariant NKT cells from the inhibitory effects of PD-1
    Jianxiong Wang
    Department of Biochemistry and Molecular Biology, Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Immunol 182:6644-7. 2009
    ..The opposing functions of CD28 and PD-1 thus tightly regulate the unique effector function iNKT cells...
  92. pmc B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion
    Friederike C Rau
    Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA
    J Immunol 183:7661-71. 2009
    ..Taken together, these results identify direct signaling through B7-1/2 as a potent regulator of IgG secretion by previously activated B cells...
  93. pmc Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation
    Haiyan Ying
    Laboratory of Molecular Cancer Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    J Immunol 185:1375-8. 2010
    ..With these results, we are the first to demonstrate that CTLA-4-B7 interaction inhibits Th17 differentiation in vitro and in vivo and suppresses Th17-mediated autoimmunity...
  94. pmc An obligate cell-intrinsic function for CD28 in Tregs
    Ruan Zhang
    Transplant Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 123:580-93. 2013
    ....
  95. pmc The costimulatory molecule B7 is expressed in the medullary region of the murine thymus
    H Reiser
    Division of Lymphocyte Biology, Dana Farber Cancer Institute, Boston, MA 02115
    Immunology 81:532-7. 1994
    ..Finally, although we have demonstrated expression of mB7 in the murine thymus, we have been unable to detect a function for this antigen in this organ. The implications of these findings are discussed...
  96. pmc CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis
    Xue Feng Bai
    Division of Cancer Immunology, Department of Pathology, Ohio State University Medical Center, 129 Hamilton Hall, 1645 Neil Ave, Columbus 43210, USA
    J Exp Med 200:447-58. 2004
    ....
  97. ncbi A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA
    Eur J Immunol 35:418-27. 2005
    ..Together these findings demonstrate a novel negative regulatory role for CD28 in inhibiting differentiation of SP thymocytes, probably through inhibition of thymic selection...
  98. ncbi [Clone and expression of murine BTLA extracellular domain gene and its effect on the expression of B7 on dendritic cells]
    Jun Fa Xu
    Department of Immunology, Tongji Medical College, Huazhong Universite of Science and Technology, Wuhan 430030, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:413-6. 2006
    ..4...
  99. pmc CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance
    Josef Kurtz
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Blood 113:3475-84. 2009
    ..This tolerance is independent of regulatory T cells and culminates in the deletion of directly alloreactive CD4 T cells...
  100. doi Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity
    Siew Cheng Wong
    Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore
    Cell Immunol 256:64-71. 2009
    ..Taken together, our data reveal a functional hierarchy of the CD28/B7 and ICOS/B7-H2 pathways and delineated their relative contributions to the elicitation of a DTH response...
  101. pmc Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection
    Edward Seung
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 186:6830-8. 2011
    ..These data suggest that transplantation tolerance can be achieved by reducing the recruitment of some, but not necessarily all, CD8(+) Teff into the target organ and suggest a novel approach to achieve transplant tolerance...

Research Grants6

  1. The Alternative NFkB Pathway in Survival and Function of Anti-Viral T Cells
    David Parker; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  2. MYCOPLASMA SUPERANTIGEN MAM IN DISEASE AND AUTOIMMUNITY
    Hong Hua Mu; Fiscal Year: 2003
    ..Specifically the investigator shall define the role played by SAg-induced cytokines and protection against disease using the MAM vaccines described earlier. ..
  3. CD80 binding peptides as therapeutic agents in arthritis
    Mythily Srinivasan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  4. THE IMMUNOBIOLOGY OF MURINE ALLOGRAFT ACCEPTANCE
    Charles Cook; Fiscal Year: 2007
    ..In general, these studies will explore the immunobiology of murine allograft acceptance, and its relationship to allograft tolerance. ..
  5. T Cell Memory to Respiratory Viral Infections
    Shahram Salek Ardakani; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..