B2m

Summary

Gene Symbol: B2m
Description: beta-2 microglobulin
Alias: Ly-m11, beta2-m, beta2m, beta-2-microglobulin
Species: mouse

Top Publications

  1. ncbi Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
    M Zijlstra
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
    Nature 344:742-6. 1990
  2. ncbi Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways
    Nadine L Dudek
    St Vincent s Institute, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Diabetes 55:2412-8. 2006
  3. ncbi Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
    J Katz
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Strasbourg, France
    Eur J Immunol 23:3358-60. 1993
  4. pmc Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Nat Immunol 9:1122-30. 2008
  5. pmc CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice
    Sarah E Weber
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 186:432-42. 2011
  6. ncbi The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
    Xiao He
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
    Nature 433:826-33. 2005
  7. ncbi Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
    David E Oppenheim
    Peter Gorer Department of Immunobiology, Guy s King s St Thomas School of Medicine, King s College, Guy s Hospital Campus, London SE1 9RT, UK
    Nat Immunol 6:928-37. 2005
  8. pmc Selection and expansion of CD8alpha/alpha(1) T cell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules
    S H Park
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Exp Med 190:885-90. 1999
  9. pmc NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy
    Nadia Guerra
    Department of Molecular and Cell Biology, 489 Life Sciences Addition, University of California, Berkeley, Berkeley, CA 94720, USA
    Immunity 28:571-80. 2008
  10. pmc Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice
    Sophia D Sarafova
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Immunity 31:480-90. 2009

Research Grants

  1. TREATMENT OF BURN-INDUCED IMMUNOSUPPRESSION
    Edward Sherwood; Fiscal Year: 2002
  2. MECHANISMS OF NONSTERILIZING IMMUNITY IN MALARIA
    WILLIAM WEIDANZ; Fiscal Year: 2008
  3. FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERS
    MARY CORR; Fiscal Year: 2004
  4. B Cell Expansion After Dendritic Cell Immunization
    Michael Jordan; Fiscal Year: 2004
  5. MHC Class l-independent NK Cell Regulation
    Koho Iizuka; Fiscal Year: 2006
  6. Pathogenic mechanisms that initiate DMD
    Robert Grange; Fiscal Year: 2006
  7. Anti-Tumor Autoimmunity by lymphopenia T cell Expansion
    Roberto Baccala; Fiscal Year: 2008
  8. Becton Dickinson LSR-II Analytical Cytometer (BD-LSR-II)
    David Serreze; Fiscal Year: 2008
  9. ANTIGEN PRESENTING CELL DEFECTS IN AUTOIMMUNE DIABETES
    David Serreze; Fiscal Year: 2009
  10. Pneumococcal immunization through a novel mechanism
    Richard Malley; Fiscal Year: 2010

Detail Information

Publications150 found, 100 shown here

  1. ncbi Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
    M Zijlstra
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
    Nature 344:742-6. 1990
    ....
  2. ncbi Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways
    Nadine L Dudek
    St Vincent s Institute, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Diabetes 55:2412-8. 2006
    ..Therefore, NOD8.3 T-cells use both perforin and Fas pathways to kill beta-cells and the surprising blockade of NOD8.3 T-cell-mediated beta-cell death by SOCS-1 overexpression may be due in part to reduced target cell recognition...
  3. ncbi Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
    J Katz
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Strasbourg, France
    Eur J Immunol 23:3358-60. 1993
    ..We question this interpretation because NOD mice lacking MHC class I molecules, hence CD8+ T cells, do not display even insulitis when expected...
  4. pmc Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Nat Immunol 9:1122-30. 2008
    ..We propose that GATA-3 acts as a specification factor for the CD4(+) lineage 'upstream' of the ThPOK-controlled CD4(+) commitment checkpoint...
  5. pmc CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice
    Sarah E Weber
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 186:432-42. 2011
    ....
  6. ncbi The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
    Xiao He
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
    Nature 433:826-33. 2005
    ....
  7. ncbi Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
    David E Oppenheim
    Peter Gorer Department of Immunobiology, Guy s King s St Thomas School of Medicine, King s College, Guy s Hospital Campus, London SE1 9RT, UK
    Nat Immunol 6:928-37. 2005
    ..Thus, NKG2D engagement is a natural mediator of immunosurveillance, which can be compromised by locally sustained ligand expression but potentially restored by innate immune activation...
  8. pmc Selection and expansion of CD8alpha/alpha(1) T cell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules
    S H Park
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Exp Med 190:885-90. 1999
    ....
  9. pmc NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy
    Nadia Guerra
    Department of Molecular and Cell Biology, 489 Life Sciences Addition, University of California, Berkeley, Berkeley, CA 94720, USA
    Immunity 28:571-80. 2008
    ..These findings provide important genetic evidence for surveillance of primary tumors by an NK receptor...
  10. pmc Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice
    Sophia D Sarafova
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Immunity 31:480-90. 2009
    ..Thus, the kinetics of CD4 coreceptor expression during MHC II-specific positive selection determines the integrity of CD4 lineage choice, revealing an elegant symmetry between coreceptor kinetics and lineage choice...
  11. pmc Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3
    Hoonsik Cho
    Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611, USA
    J Immunol 186:489-98. 2011
    ..These data demonstrate that other MHC class Ib-restricted CD8(+) T cells, in addition to H2-M3-restricted T cells, contribute to antilisterial immunity and may contribute to immune responses against other intracellular bacteria...
  12. pmc The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 204:1945-57. 2007
    ..These results indicate that Runx proteins have important roles at multiple stages of T cell development and in the homeostasis of mature T cells...
  13. pmc Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID beta2mnull mice
    Bruno Nervi
    Division of Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA
    Exp Hematol 35:1823-38. 2007
    ..Models of immunodeficient mice that consistently and efficiently reconstitute with xenoreactive human T cells would be a valuable tool for the in vivo study of GVHD, as well as other human immune responses...
  14. pmc Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses
    M K Spriggs
    Department of Molecular Biology, Immunex Research and Development Corporation, Seattle, WA 98101
    Proc Natl Acad Sci U S A 89:6070-4. 1992
    ..These data indicate that CD8+ lymphocytes are not required to clear high doses of vaccinia virus, and they suggest that beta 2m-/- mice are less efficient at antigen-specific IgG production than their beta 2m+/- littermates...
  15. ncbi Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection
    H Suzuki
    Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Immunity 2:413-25. 1995
    ..These results are incompatible with current concepts and require a new perspective on lineage commitment and positive selection, which we refer to as asymmetric commitment...
  16. ncbi Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice
    R M Locksley
    Department of Medicine, University of California, San Francisco 94143 0654
    Science 261:1448-51. 1993
    ..These results indicate that T lymphocyte lineage commitment and peripheral function need not depend on the function of CD4...
  17. pmc Visualization of CD4/CD8 T cell commitment
    S Chan
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Strasbourg, 67404 Illkirch Cedex, France
    J Exp Med 188:2321-33. 1998
    ..Finally, we found no evidence of a CD4 default pathway...
  18. pmc Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways
    Lucinda F Reynolds
    National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Exp Med 195:1103-14. 2002
    ..We show that this latter function is independent of PI3K...
  19. pmc Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice
    Michele P Marron
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 99:13753-8. 2002
    ..These findings provide the first functional evidence that certain human MHC class I molecules can contribute to the development of T1D...
  20. pmc Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis
    Karine Crozat
    The Scripps Research Institute TSRI, La Jolla, CA 92037, USA
    J Exp Med 204:853-63. 2007
    ..In contrast, neither Listeria monocytogenes nor MCMV induces the syndrome. In mice, the HLH phenotype is conditional, which suggests the existence of a specific infectious trigger of FHL3 in humans...
  21. pmc Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection
    J L Flynn
    Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 89:12013-7. 1992
    ..These data indicate that functional CD8 T cells, and possibly T cells bearing gamma delta antigen receptor, are a necessary component of a protective immune response to M. tuberculosis in mice...
  22. ncbi Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice
    M Bix
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Nature 349:329-31. 1991
    ..These findings demonstrate that deficient expression of MHC-I molecules renders marrow cells susceptible to rejection...
  23. pmc The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I
    R Glas
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    J Exp Med 179:661-72. 1994
    ..The first "MHC deficient" animals thus paradoxically provide a tool for direct demonstration and analysis of self MHC bias in the T cell repertoire...
  24. pmc Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture
    K A Hogquist
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle 98195
    J Exp Med 177:1469-73. 1993
    ..Fetal thymus lobes from mice deficient in the class I light chain (beta 2 microglobulin or beta 2 M-/-) were cultured for 10 d in vitro, during which time T cell precursors develop into mature T ..
  25. ncbi Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice
    V Ghetie
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235 8576, USA
    Eur J Immunol 26:690-6. 1996
    ..These findings suggest that FcRn is involved in IgG homeostasis...
  26. pmc Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man
    M Santos
    Department of Immunology, Eijkman Winkler Institute, Utrecht, The Netherlands
    J Exp Med 184:1975-85. 1996
    ..Our data provide functional support for the proposed causative role of HLA-H mutations in HH...
  27. ncbi Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice
    M Salcedo
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    J Immunol 158:3174-80. 1997
    ..1+ cells from B6 (H-2b) and D8 (B6 mice transgenic for H-2Dd) mice as well as corresponding TAP1 -/-, beta2m -/-, and TAP1/beta2m -/- mutants of these mice. We demonstrate that receptor expression on NK1...
  28. ncbi Tissue-specific recognition of mouse CD1 molecules
    S H Park
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    J Immunol 160:3128-34. 1998
    ..They suggest that CD1.1 may be naturally associated with a variety of self ligands that overlap only partially in different cell types...
  29. pmc Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B
    L H Ho
    Division of Developmental Immunology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Proc Natl Acad Sci U S A 96:15086-90. 1999
    ..These findings suggest a physiological inhibitory role for PIR-B that is regulated by endogenous MHC class I-like ligands...
  30. ncbi A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung
    C D D'Souza
    Mycobacterial Research Laboratories, Departments of Microbiology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    Am J Respir Cell Mol Biol 23:188-93. 2000
    ....
  31. ncbi A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor
    Eugene Y Chiang
    Center for Immunology, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 173:4394-401. 2004
    ..Collectively, these studies demonstrate that a MHC class Ib molecule can serve as a restriction element for antitumor CTL and mediate protective immune responses in a syngeneic setting...
  32. pmc Mice lacking major histocompatibility complex class I and class II molecules
    M J Grusby
    Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115
    Proc Natl Acad Sci U S A 90:3913-7. 1993
    ..Taken together, these results emphasize the plasticity of the immune system and suggest that MHC-deficient mice may be useful for examining compensatory mechanisms in severely immunocompromised animals...
  33. pmc IL-7 is critical for homeostatic proliferation and survival of naive T cells
    J T Tan
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:8732-7. 2001
    ..Thus, naïve T cells disappeared gradually over a 1-month period upon adoptive transfer into IL-7(-) hosts. These findings indicate that naive T cells depend on IL-7 for survival and homeostatic proliferation...
  34. ncbi Ham-2 corrects the class I antigen-processing defect in RMA-S cells
    M Attaya
    Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0678
    Nature 355:647-9. 1992
    ..These data indicate that both MHC-linked transporter genes are probably required for class I antigen processing, and that the functional transporter in this pathway may consist of a Ham-1/Ham-2 heterodimer...
  35. ncbi Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells
    B H Koller
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Science 248:1227-30. 1990
    ..The homozygotes appeared normal, although no class I antigens could be detected on their cells and the animals are grossly deficient in CD4- CD8+ T cells, which normally mediate cytotoxic T cell function...
  36. ncbi Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells
    M Zijlstra
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts
    Nature 342:435-8. 1989
    ..Chimaeric mice derived from blastocysts injected with mutant embryonic stem cell clones transmit the mutant allele to their offspring...
  37. ncbi NK cell response to viral infections in beta 2-microglobulin-deficient mice
    C H Tay
    Department of Pathology, University of Massachusetts Medical Center, Worcester 01655
    J Immunol 154:780-9. 1995
    ....
  38. ncbi Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on Listeria monocytogenes infection
    C H Ladel
    Department of Immunology, University of Ulm, Germany
    J Immunol 153:3116-22. 1994
    ..monocytogenes and point to the necessity of a coordinated interaction between CD8 and CD4 alpha beta T cells (and probably gamma delta T cells) in anti-L. monocytogenes resistance...
  39. ncbi Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin
    P F Mixter
    Department of Medicine, University of Vermont College of Medicine, Burlington 05405
    J Immunol 154:2063-74. 1995
    ..Thus, absence of class I MHC-positive selection of CD8+ and CD4-CD8- TCR-alpha beta + cells limits the autoimmune diathesis observed in beta 2-m+/+ lpr/lpr mice...
  40. ncbi Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points
    G P Linette
    Howard Hughes Medical Institute, Department of Medicine and Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    Immunity 1:197-205. 1994
    ..In RAG-1-I- mice, Bcl-2 promoted differentiation to the CD4+ CD8+ stage. Bcl-2 can promote thymocyte maturation at several control points...
  41. pmc Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor
    J Kirberg
    Basel Institute for Immunology, Switzerland
    J Exp Med 180:25-34. 1994
    ..The results are compatible with the notion that T cell maturation requires multiple receptor-ligand interactions and establish an exception to the rule that class II-restricted TCRs are exclusively expressed by mature CD4+8- cells...
  42. ncbi Iron overload in beta 2-microglobulin-deficient mice
    M de Sousa
    Abel Salazar Institute for the Biomedical Sciences, Oporto, Portugal
    Immunol Lett 39:105-11. 1994
    ....
  43. ncbi Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes
    L S Wicker
    Department of Autoimmune Diseases Research, Merck Research Laboratories, Rahway, New Jersey 07065 0900
    Diabetes 43:500-4. 1994
    ..These results demonstrate an essential role for CD8+ T-cells in the initiation of the autoimmune response to beta-cells in the NOD mouse...
  44. ncbi Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant
    D V Serreze
    Jackson Laboratory, Bar Harbor, ME 04609
    Diabetes 43:505-9. 1994
    ..MHC class I molecules have been shown to accumulate intracellularly in the presence of a disrupted B2m locus, but this mutation does not negatively affect plasma insulin levels in either NOD/Lt mice or in those of a ..
  45. pmc Highly lytic CD8+, alpha beta T-cell receptor cytotoxic T cells with major histocompatibility complex (MHC) class I antigen-directed cytotoxicity in beta 2-microglobulin, MHC class I-deficient mice
    S Apasov
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:2837-41. 1993
    ....
  46. ncbi Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice
    Y Fujiura
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    J Immunol 156:2710-5. 1996
    ....
  47. pmc The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor
    R P Junghans
    Biotherapeutics Development Lab, Department of Medicine, Harvard Medical School, Boston, MA 02215
    Proc Natl Acad Sci U S A 93:5512-6. 1996
    ..This result also identifies an important new member of the class of recycling surface receptors and enables the design of protein adaptations to exploit this mechanism to improve survivals of other therapeutic proteins in vivo...
  48. pmc beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism
    B E Rothenberg
    Department of Medicine, University of California at San Diego, La Jolla, 92093 0634, USA
    Proc Natl Acad Sci U S A 93:1529-34. 1996
    ..that mice which have altered expression of class I gene products, the beta2-microglobulin knockout mice, [beta2m(-/-)], would develop Fe overload...
  49. ncbi RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice
    T W Kay
    Burnet Clinical Research Unit, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 157:3688-93. 1996
    b>Beta2m-deficient nonobese diabetic (NODbeta2mnull) do not develop insulitis or diabetes...
  50. ncbi An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
    E Robey
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 87:483-92. 1996
    ..However, activated Notch is not sufficient to promote CD8 cell development when both class I and class II MHC are absent. These results implicate Notch as a participant in the CD4 versus CD8 lineage decision...
  51. pmc Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRn
    E J Israel
    Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    Immunology 89:573-8. 1996
    ..These data suggest that FcRn can protect IgG from degradation, and is therefore important in maintaining IgG levels in the circulation...
  52. ncbi Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent
    D V Serreze
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 158:3978-86. 1997
    ..does not occur in NOD mice made MHC class I-deficient by a functionally inactivated beta2-microglobulin allele (beta2m(null))...
  53. pmc HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice
    S Pascolo
    Institut Pasteur, Département SIDA Rétrovirus, Unité d Immunité Cellulaire Antivirale, 75724 Paris Cedex 15, France
    J Exp Med 185:2043-51. 1997
    Three different HLA-A2.1 monochains were engineered in which either the human or mouse beta2-microglobulin (beta2m) is covalently linked to the NH2 terminus of the heavy chain by a 15- amino acid long peptide: HHH, entirely human, HHD, ..
  54. ncbi Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides
    C E Grubin
    Department of Immunology, University of Washington, Seattle 98195, USA
    Immunity 7:197-208. 1997
    ..In addition, the data suggest that T cell receptor repertoires selected in wild-type mice and in mice displaying limited spectra of self-peptides are distinct...
  55. ncbi The basis for self-tolerance of natural killer cells in beta2-microglobulin- and TAP-1- mice
    J R Dorfman
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California at Berkeley, 94720, USA
    J Immunol 159:5219-25. 1997
    Cells from mice with mutations in the genes for beta2-microglobulin (beta2m) or for TAP-1 express only low levels of MHC class I proteins on their surfaces, and are thus sensitive to attack by normal NK cells...
  56. ncbi Timing and casting for actors of thymic negative selection
    N Dautigny
    Institut National de la Sante et de la Recherche Medicale, Unit 345, Institut Necker, Paris, France
    J Immunol 162:1294-302. 1999
    ..Finally, we show involvement in opposing directions for p59fyn and SHP-1 molecules in signaling for thymic negative selection...
  57. ncbi Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells
    U Steinhoff
    Department of Immunology, Max Planck Institute of Infection Biology, Germany
    Immunity 11:349-58. 1999
    ..This report demonstrates that CD8 T cells with defined antigen specificity cause intestinal inflammation, emphasizing a link between infection and autoimmune disease...
  58. ncbi Regulation of lineage commitment distinct from positive selection
    R Keefe
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 286:1149-53. 1999
    ..However, neither TCR-mediated signaling nor positive selection is impaired. Thus, the HD mutation provides genetic evidence that lineage commitment may be mechanistically distinct from positive selection...
  59. ncbi Persistence of memory CD8 T cells in MHC class I-deficient mice
    K Murali-Krishna
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA
    Science 286:1377-81. 1999
    ..Thus, after naïve CD8 T cells differentiate into memory cells, they evolve an MHC class I-independent "life-style" and do not require further stimulation with specific or cross-reactive antigen for their maintenance...
  60. ncbi NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells
    M C Coles
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    J Immunol 164:2412-8. 2000
    ..1+ T cells or are induced to proliferate after having left the thymus. The results indicate that NK1.1+ T cells, like conventional T cells, arise in the thymus where they are selected by interactions with restricting molecules...
  61. ncbi Effect of B2m gene disruption on MHC-determined odortypes
    J Bard
    Microbiology and Immunology, University of Arizona College of Medicine, Tucson 85724, USA
    Immunogenetics 51:514-8. 2000
    ..they lack beta2-microglobulin are distinguishable by scent from otherwise identical mice which possess an intact B2m gene...
  62. pmc Functional requirement for class I MHC in CNS development and plasticity
    G S Huh
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Science 290:2155-9. 2000
    ..These results demonstrate an important role for these molecules in the activity-dependent remodeling and plasticity of connections in the developing and mature mammalian central nervous system (CNS)...
  63. ncbi MHC class Ia-restricted T cells partially account for beta2-microglobulin-dependent resistance to Mycobacterium tuberculosis
    M S Rolph
    Dept of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Eur J Immunol 31:1944-9. 2001
    ..Thus, antigen presentation via MHC class Ia is an important component in resistance to M. tuberculosis, but its absence only partially accounts for the increased susceptibility of beta 2-microglobulin-deficient mice...
  64. ncbi Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage
    Y R Zou
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Genet 29:332-6. 2001
    ..The epigenetic inheritance of the silenced CD4 locus was not affected by the inhibition of DNA methylation or histone deacetylation, and may thus involve other mechanisms that ensure a stable state of gene expression...
  65. ncbi A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development
    B J Fowlkes
    Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:1817-21. 2002
    ..We suggest that the discrepancies in previous reports of Notch1IC transgenic mice are due to differences in the propensity of the two different transgenic lines to develop tumors...
  66. ncbi Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells
    Mariëlle C Haks
    Division of Basic Sciences, Immunobiology Working Group, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 170:2853-61. 2003
    ..Taken together these data suggest that cell-autonomous, ligand-independent signaling is primarily a property of the thymocytes in which pre-TCR signaling occurs...
  67. ncbi In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla
    Mariam Nasreen
    Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan
    J Immunol 171:3394-400. 2003
    ....
  68. pmc The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells
    Aaron J Tyznik
    Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    J Exp Med 199:559-65. 2004
    ..These results have implications for understanding CD4 versus CD8 lineage commitment in the thymus, and for the practical use of CD4-/- mice as models of helper deficiency...
  69. ncbi An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder
    Michael B Jordan
    Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, USA
    Blood 104:735-43. 2004
    ..These studies provide insight into the pathophysiology of HLH, and provide new targets for specific therapeutic intervention in this fatal disorder...
  70. ncbi Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage
    Kazuyoshi Kohu
    Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Immunol 174:2627-36. 2005
    ..Thus, Runx3 can drive thymocytes to select the CD4(-)8(+) lineage. This activity is likely to be due to more than a simple silencing of CD4 gene expression...
  71. ncbi Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes
    Takehito Sato
    Department of Immunology, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259 1193, Japan
    Immunity 22:317-28. 2005
    ....
  72. ncbi Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    Jason D Fontenot
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Immunity 22:329-41. 2005
    ..Analysis of Foxp3 expression during thymic development suggests that this mechanism is not hard-wired but is dependent on TCR/MHC ligand interactions...
  73. ncbi Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity
    Sophia D Sarafova
    Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Immunity 23:75-87. 2005
    ..This study demonstrates that termination of coreceptor transcription during positive selection promotes CD8-lineage fate, regardless of TCR specificity or coreceptor protein identity...
  74. ncbi HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes
    Toshiyuki Takaki
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 176:3257-65. 2006
    ..In particular, the identified antigenic peptides represent promising tools to explore the potential importance of IGRP in the development of human T1D...
  75. ncbi Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
    Mark A Daniels
    Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland
    Nature 444:724-9. 2006
    ....
  76. ncbi In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice
    Irene Jarchum
    Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Diabetes 56:2551-60. 2007
    ..The development of peptide-based therapeutic reagents that target islet-reactive CD8(+) T-cells will require the identification of disease-relevant epitopes...
  77. pmc Development of all CD4 T lineages requires nuclear factor TOX
    Parinaz Aliahmad
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:245-56. 2008
    ..Our data suggest that TOX-dependent transition to the CD4(+)CD8(lo) stage is required for continued development of class II major histocompatibility complex-specific T cells, regardless of ultimate lineage fate...
  78. doi CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus
    Xi He
    Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
    Immunity 28:346-58. 2008
    ..We propose a silencer-dependent model of lineage choice, whereby inactivation of the DRE silencer by a strong TCR signal leads to CD4 commitment, whereas continued silencer activity leads to CD8 commitment...
  79. pmc Continuous engagement of a self-specific activation receptor induces NK cell tolerance
    Sandeep K Tripathy
    Gastroenterology Division, Department of Medicine, Washington University School of Medicine and Howard Hughes Medical Institute, St Louis, MO 63110, USA
    J Exp Med 205:1829-41. 2008
    ..Thus, engagement of self-specific activation receptors in vivo induces an NK cell tolerance effect that is not affected by self-MHC-specific inhibitory receptors...
  80. pmc ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage
    Takeshi Egawa
    Molecular Pathogenesis Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nat Immunol 9:1131-9. 2008
    ..Our results suggest that MHC class II-selected thymocytes are directed toward the CD4(+) lineage independently of ThPOK but require ThPOK to prevent Runx-dependent differentiation toward the CD8(+) lineage...
  81. doi Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
    Sawako Muroi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Nat Immunol 9:1113-21. 2008
    ..Our results show how an initial lineage-specification signal can be amplified and stabilized during the lineage-commitment process...
  82. doi The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator
    Yu Hikosaka
    Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770 8503, Japan
    Immunity 29:438-50. 2008
    ..These results indicate that RANKL produced by positively selected thymocytes is responsible for fostering thymic medulla formation, thereby establishing central tolerance...
  83. ncbi Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic
    Stanley Adoro
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 181:6975-83. 2008
    ..However, the E8(I)-CD4 transgene did not reveal any MHC-II-selected thymocytes that adopted the CD8 lineage fate. These results demonstrate that CD4/CD8 lineage choice is neither error-prone nor stochastic...
  84. pmc The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals
    Koichi Yanaba
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 182:7459-72. 2009
    ..Thereby, both adaptive and innate signals regulate B10 cell development, maturation, CD5 expression, and competence for IL-10 production...
  85. pmc Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex
    M A King
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Clin Exp Immunol 157:104-18. 2009
    ..This model now provides the opportunity to investigate in vivo mechanisms of xenogeneic GVHD as well as to assess the efficacy of therapeutic agents rapidly...
  86. pmc Coreceptor gene imprinting governs thymocyte lineage fate
    Stanley Adoro
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    EMBO J 31:366-77. 2012
    ..This study identifies coreceptor gene imprinting as a critical determinant of lineage fate determination in the thymus...
  87. pmc Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice
    I Correa
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Proc Natl Acad Sci U S A 89:653-7. 1992
    ..We conclude that class I expression is unnecessary for the development of most gamma delta+ T cells...
  88. pmc Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes
    M C Coles
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    J Exp Med 180:395-9. 1994
    ..We propose that these populations are selected by nonpolymorphic class Ib or CD1 molecules...
  89. ncbi Another view of the selective model of thymocyte selection
    S H Chan
    Laboratoire de Genetique Moleculaire, Eucaryotes du Centre National de la Recherche Scientifique, Faculte de Medecine, Strasbourg, France
    Cell 73:225-36. 1993
    ....
  90. ncbi Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
    C B Davis
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0414
    Cell 73:237-47. 1993
    ....
  91. ncbi Development of mature CD8+ thymocytes: selection rather than instruction?
    J P van Meerwijk
    Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Science 261:911-5. 1993
    ....
  92. ncbi Peptide dependency of alloreactive CD4+ T cell responses
    S K Mendiratta
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Int Immunol 11:351-60. 1999
    ..APC from these mice were used as targets and stimulators for alloreactive CD4+ T cells. Results demonstrated that the vast majority of CD4+ alloreactive T cells recognize MHC class II molecules in a peptide-dependent fashion...
  93. ncbi Perforin-dependent cytolytic responses in beta2-microglobulin-deficient mice
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Studley Road, Heidelberg, Victoria, 3084, Australia
    Cell Immunol 196:51-9. 1999
    ..Dependence on perforin function was demonstrated for the cytotoxicity of these effectors in vitro and for the ability of these effectors to reject a variety of tumors in vivo...
  94. pmc Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells
    E A Green
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Exp Med 191:225-38. 2000
    ..These data provide new insights into the mechanisms by which inflammatory stimuli can bypass CD154-CD40 immune regulatory signals and cause activation of autoreactive T cells...
  95. ncbi Transgenic expression of Ly49A on T cells impairs a specific antitumor response
    P Brawand
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    J Immunol 165:1871-6. 2000
    ....
  96. ncbi The source of early IFN-gamma that plays a role in Th1 priming
    G Das
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 167:2004-10. 2001
    ..Therefore, they arise on MHC class Ib molecules that do not depend on TAP-1 transporters...
  97. ncbi Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection
    R L Tarleton
    Department of Zoology, University of Georgia, Athens 30602
    Nature 356:338-40. 1992
    ..cruzi infection. They also implicate CD8+ T cells and/or class I MHC molecules in regulation of lymphokine production and recruitment of inflammatory cells...
  98. ncbi Genetic analysis of autoimmune type 1 diabetes mellitus in mice
    J A Todd
    Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford, UK
    Nature 351:542-7. 1991
    ..On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17...
  99. ncbi Requirement for positive selection of gamma delta receptor-bearing T cells
    F B Wells
    Biological Carcinogenesis and Development Program, Program Resources, Inc DynCorp, NCI Frederick Cancer Research and Development Center, MD 21701 0201
    Science 253:903-5. 1991
    ..T cells, mice bearing a class I MHC-specific gamma delta transgene (Tg) were crossed to mice with disrupted beta 2 microglobulin (beta 2M) genes...
  100. pmc Interspecific backcross mice show sex-specific differences in allelic inheritance
    L D Siracusa
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Genetics 128:813-21. 1991
    ..1 and Neb) to chromosome 2, which, in addition to the Abl, Ada, B2m, Bmp-2a, Hc, Emv-15, Fshb, Hck-1, Pax-1, Pck-1, Spna-2 and Vim loci previously mapped in our interspecific ..
  101. ncbi Sequences homologous to glutamic acid decarboxylase cDNA are present on mouse chromosomes 2 and 10
    M H Brilliant
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 6:115-22. 1990
    ..The Gad-1 locus is part of a conserved homology between mouse chromosome 2 and the long arm of human chromosome 2...

Research Grants12

  1. TREATMENT OF BURN-INDUCED IMMUNOSUPPRESSION
    Edward Sherwood; Fiscal Year: 2002
    ..Administration of glucan to thermally injured mice will promote IL-12, IL-18 and IFNgamma production, increase type 1 T cell predominance and enhance resistance to infection. ..
  2. MECHANISMS OF NONSTERILIZING IMMUNITY IN MALARIA
    WILLIAM WEIDANZ; Fiscal Year: 2008
    ..abstract_text> ..
  3. FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERS
    MARY CORR; Fiscal Year: 2004
    ..The results of these studies will both contribute to, and will utilize, the resources of the OA biomarker consortium. ..
  4. B Cell Expansion After Dendritic Cell Immunization
    Michael Jordan; Fiscal Year: 2004
    ..My near term career path will involve ongoing basic research and study in order to improve my ultimate scientific productivity. ..
  5. MHC Class l-independent NK Cell Regulation
    Koho Iizuka; Fiscal Year: 2006
    ..2) Determine the role of Nkrpl/Clr genes in NK cell development. These studies are critical to our understanding of innate immunity and improving the manipulation of NK cells for therapeutic purposes. ..
  6. Pathogenic mechanisms that initiate DMD
    Robert Grange; Fiscal Year: 2006
    ..These studies will provide valuable insight for the development of therapeutic interventions to prevent the onset of DMD. ..
  7. Anti-Tumor Autoimmunity by lymphopenia T cell Expansion
    Roberto Baccala; Fiscal Year: 2008
    ..The results will define the role of homeostatic T cell proliferation in tumor autoimmunity, and provide new approaches to the treatment of cancer. [unreadable] [unreadable]..
  8. Becton Dickinson LSR-II Analytical Cytometer (BD-LSR-II)
    David Serreze; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. ANTIGEN PRESENTING CELL DEFECTS IN AUTOIMMUNE DIABETES
    David Serreze; Fiscal Year: 2009
    ..Successful completion of our proposed studies might ultimately provide means for preventing the development of this devastating disease. ..
  10. Pneumococcal immunization through a novel mechanism
    Richard Malley; Fiscal Year: 2010
    ..abstract_text> ..
  11. Pneumolysin, Innate and Acquired Immunity to Pneumococci
    Richard Malley; Fiscal Year: 2005
    ..The establishment of a link between the innate and the acquired arm of the immune response to pneumococcus may provide a better understanding of the mechanisms by which immunity to pneumococcus is acquired. ..
  12. Regulation of Lineage Specificity of CD4 Silencing
    Yong Rui Zou; Fiscal Year: 2008
    ..Here, we will determine whether the level of nuclear CBFbeta proteins in CD4+ and CD8+ T cells may affect CD4 silencing, by overexpression or RNAi blocking experiments. ..