Avpr1b

Summary

Gene Symbol: Avpr1b
Description: arginine vasopressin receptor 1B
Alias: AVPR3, V3/V1b, VIBR, VPR3, vasopressin V1b receptor, AVPR V1b, AVPR V3, V3/V1b pituitary vasopressin receptor, antidiuretic hormone receptor 1b, arginine vasopressin type 1b receptor, vasopressin V3 receptor
Species: mouse

Top Publications

  1. ncbi Structure and sequence of the mouse V1a and V1b vasopressin receptor genes
    S Kikuchi
    Department of Molecular, Cell Pharmacology, National Children s Medical Research Center, Tokyo, Japan
    Jpn J Pharmacol 81:388-92. 1999
  2. ncbi Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor
    Victoria J Wesley
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, U K
    Biochemistry 41:5086-92. 2002
  3. ncbi Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task
    Scott R Wersinger
    Section on Neural Gene Expression, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
    Horm Behav 46:638-45. 2004
  4. pmc Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice
    S R Wersinger
    Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA
    Genes Brain Behav 6:653-60. 2007
  5. pmc Persistence of reduced aggression in vasopressin 1b receptor knockout mice on a more "wild" background
    Heather K Caldwell
    Department of Biological Sciences and the School of Biomedical Sciences, Kent State University, Kent, OH 44242, United States
    Physiol Behav 97:131-4. 2009
  6. pmc Vasopressin 1b receptor knock-out impairs memory for temporal order
    Loren M DeVito
    Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 29:2676-83. 2009
  7. pmc Social approach behaviors are similar on conventional versus reverse lighting cycles, and in replications across cohorts, in BTBR T+ tf/J, C57BL/6J, and vasopressin receptor 1B mutant mice
    Mu Yang
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, USA
    Front Behav Neurosci 1:1. 2007
  8. doi The role of the vasopressin 1b receptor in aggression and other social behaviours
    Heather K Caldwell
    Department of Biological Sciences, Kent State University, Kent, OH, USA
    Prog Brain Res 170:65-72. 2008
  9. doi Effects of vasopressin V1b receptor deficiency on adrenocorticotropin release from anterior pituitary cells in response to oxytocin stimulation
    Kazuaki Nakamura
    Department of Pharmacology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    Endocrinology 149:4883-91. 2008
  10. doi Pituitary-adrenal response to acute and repeated mild restraint, forced swim and change in environment stress in arginine vasopressin receptor 1b knockout mice
    L Q Stewart
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, University of Bristol, Bristol, UK
    J Neuroendocrinol 20:597-605. 2008

Scientific Experts

  • W S Young
  • Heather K Caldwell
  • Mu Yang
  • S J Lolait
  • Kirill Ukhanov
  • M L Scattoni
  • A V Amikishieva
  • Yan Zhou
  • Akito Tanoue
  • Gozoh Tsujimoto
  • Masami Hiroyama
  • Yoko Fujiwara
  • Kazuaki Nakamura
  • Toshinori Aoyagi
  • Atsushi Sanbe
  • Scott R Wersinger
  • Junji Yamauchi
  • S R Wersinger
  • Reiko Mizutani
  • Mathew D Edwards
  • A M O'Carroll
  • J H Pagani
  • Toyoki Mori
  • Yoshiaki Yamaguchi
  • Ja Roper
  • Loren M DeVito
  • L Q Stewart
  • R Daikoku
  • P Rene
  • Taka Aki Koshimizu
  • Shuji Itoh
  • Nobuaki Egashira
  • G Tsujimoto
  • Marco Brancaccio
  • A Tanoue
  • Johanna E Chesham
  • Elizabeth S Maywood
  • Michael H Hastings
  • Z Cui
  • D A Caruana
  • M Zhao
  • S M Dudek
  • S K Williams Avram
  • Victoria J Wesley
  • Tom R Hollon
  • Fumiyoshi Yamazaki
  • Yasushi Okuno
  • Yasutaka Mizoro
  • Masao Doi
  • Kazuki Okada
  • Toru Suzuki
  • Xin Dong
  • Hiroshi Kori
  • Jean Michel Fustin
  • Hitoshi Okamura
  • Yulin Chen
  • Jing Zhang
  • Naoki Mizuguchi
  • Y de Keyzer
  • X Bertagna
  • Shinji Kusakawa
  • Kazuhiro Momose
  • Magdalena Sauvage
  • Ryuji Tasaki
  • Rachael Konigsberg
  • Christine Lykken
  • Howard Eichenbaum
  • Masazumi Kamohara
  • Shigeki Nakamura
  • Noriko Miyauchi
  • S Kikuchi
  • Tatsuya Yamashita
  • Jennifer L Temple
  • J A Roper
  • M A Ventura
  • T Kunitake
  • Jun Ichi Birumachi
  • K Kato
  • H Kannan
  • M Christiansen
  • Meiko Fukuda
  • Sakiko Yamada
  • Yasufumi Uwahodo
  • Koji Yamamoto
  • Katsura Tottori
  • Takashi Miwa
  • Yoshitaka Yamamura
  • Sayuri Oshikawa
  • Yoko Kitagawa
  • Michihiro Fujiwara

Detail Information

Publications36

  1. ncbi Structure and sequence of the mouse V1a and V1b vasopressin receptor genes
    S Kikuchi
    Department of Molecular, Cell Pharmacology, National Children s Medical Research Center, Tokyo, Japan
    Jpn J Pharmacol 81:388-92. 1999
    ..The availability of these genes would allow us to study the functional role of V1a and V1b receptors by disrupting the gene in mice...
  2. ncbi Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor
    Victoria J Wesley
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, U K
    Biochemistry 41:5086-92. 2002
    ..This study defines, at the molecular level, the role of the N-terminus of the OTR in high-affinity agonist binding and identifies a key residue for this function...
  3. ncbi Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task
    Scott R Wersinger
    Section on Neural Gene Expression, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
    Horm Behav 46:638-45. 2004
    ..We propose that the V1bR plays an important role in social motivation, perhaps by coupling the processing, integration, and/or interpretation of chemosensory cues with the appropriate behavioral response...
  4. pmc Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice
    S R Wersinger
    Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA
    Genes Brain Behav 6:653-60. 2007
    Vasopressin affects behavior via its two brain receptors, the vasopressin 1a and vasopressin 1b receptors (Avpr1b)...
  5. pmc Persistence of reduced aggression in vasopressin 1b receptor knockout mice on a more "wild" background
    Heather K Caldwell
    Department of Biological Sciences and the School of Biomedical Sciences, Kent State University, Kent, OH 44242, United States
    Physiol Behav 97:131-4. 2009
    It has been previously reported that vasopressin 1b receptor knockout (Avpr1b(-/-)) mice have reduced levels of aggressive behavior compared to wildtype littermates...
  6. pmc Vasopressin 1b receptor knock-out impairs memory for temporal order
    Loren M DeVito
    Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 29:2676-83. 2009
    Mice lacking a functional vasopressin 1b receptor (Avpr1b) display decreased levels of aggression and social memory...
  7. pmc Social approach behaviors are similar on conventional versus reverse lighting cycles, and in replications across cohorts, in BTBR T+ tf/J, C57BL/6J, and vasopressin receptor 1B mutant mice
    Mu Yang
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, USA
    Front Behav Neurosci 1:1. 2007
    ..Five cohorts of vasopressin receptor subtype 1b (Avpr1b) null mutants, heterozygotes, and wildtype littermate controls were tested in the same social approach paradigm: ..
  8. doi The role of the vasopressin 1b receptor in aggression and other social behaviours
    Heather K Caldwell
    Department of Biological Sciences, Kent State University, Kent, OH, USA
    Prog Brain Res 170:65-72. 2008
    ..There is, however, emerging evidence and cross-species consensus that the vasopressin 1b receptor (Avpr1b) is also important in mediating the effects of Avp on behaviour...
  9. doi Effects of vasopressin V1b receptor deficiency on adrenocorticotropin release from anterior pituitary cells in response to oxytocin stimulation
    Kazuaki Nakamura
    Department of Pharmacology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    Endocrinology 149:4883-91. 2008
    ..OT-induced ACTH release is reported to be mediated by the vasopressin V1b receptor in the rat pituitary gland, which contains both OT and V1b receptors...
  10. doi Pituitary-adrenal response to acute and repeated mild restraint, forced swim and change in environment stress in arginine vasopressin receptor 1b knockout mice
    L Q Stewart
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, University of Bristol, Bristol, UK
    J Neuroendocrinol 20:597-605. 2008
    ..Arginine vasopressin mediates this action at the arginine vasopressin 1b receptor (Avpr1b) located on pituitary corticotrophs...
  11. pmc Reduced ultrasonic vocalizations in vasopressin 1b knockout mice
    M L Scattoni
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD, USA
    Behav Brain Res 187:371-8. 2008
    ..We employed a vasopressin 1b receptor (Avpr1b) knockout mouse to evaluate the role of the vasopressin 1b receptor subtype in the emission of ultrasonic ..
  12. pmc Inactivation of the oxytocin and the vasopressin (Avp) 1b receptor genes, but not the Avp 1a receptor gene, differentially impairs the Bruce effect in laboratory mice (Mus musculus)
    Scott R Wersinger
    Department of Psychology, University at Buffalo, State University of New York, NY 14260 1660, USA
    Endocrinology 149:116-21. 2008
    ..Wild-type, heterozygous, and homozygous knockout (KO) females for either the Avpr1a, Avpr1b, or Oxt genes were randomly assigned to one of the following treatment groups: 1) alone (mate removed, no second ..
  13. ncbi Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor
    M A Ventura
    Groupe d Etudes en Physiopathologie Endocrinienne, UPR 1524 CNRS, Institut Cochin de Genetique Moleculaire, CHU Cochin, Universite Paris V, 75014 Paris
    J Mol Endocrinol 22:251-60. 1999
    ..However, significant differences were found between human and mouse receptors tested in parallel. Thus the pharmacology of V3/V1b receptors can not be transposed among different species...
  14. pmc Insulin hypersensitivity in mice lacking the V1b vasopressin receptor
    Yoko Fujiwara
    Department of Pharmacology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    J Physiol 584:235-44. 2007
    ..Thus, the blockade of the V1b receptor could result, at least in part, in enhanced insulin sensitivity by altering insulin signalling in adipocytes...
  15. pmc Social dominance in male vasopressin 1b receptor knockout mice
    Heather K Caldwell
    Department of Biological Sciences and the School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA
    Horm Behav 58:257-63. 2010
    We have previously reported that mice with a targeted disruption of their vasopressin 1b receptor gene, Avpr1b, have mild impairments in social recognition and reduced aggression...
  16. ncbi Involvement of arginine vasopressin and V1b receptor in heroin withdrawal and heroin seeking precipitated by stress and by heroin
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuropsychopharmacology 33:226-36. 2008
    ....
  17. ncbi Mutual regulation of vasopressin- and oxytocin-induced glucagon secretion in V1b vasopressin receptor knockout mice
    Yoko Fujiwara
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    J Endocrinol 192:361-9. 2007
    ..we investigated the effect of these peptides on glucagon secretion in islets of wild-type (V1bR+/+) and vasopressin V1b receptor knockout (V1bR-/-) mice...
  18. pmc The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors
    Stephen J Lolait
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
    Endocrinology 148:849-56. 2007
    The role of arginine vasopressin (Avp) as an ACTH secretagogue is mediated by the Avp 1b receptor (Avpr1b) found on anterior pituitary corticotropes...
  19. ncbi The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors
    Heather K Caldwell
    Section on Neural Gene Expression, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
    Neuropeptides 40:325-37. 2006
    ..Centrally only two Avp receptor subtypes are expressed: the 1a receptor (Avpr1a) and the 1b receptor (Avpr1b)...
  20. pmc The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy
    W S Young
    Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 49, Room 5A56, Bethesda, MD 20892 4483, USA
    Neuroscience 143:1031-9. 2006
    The vasopressin 1b receptor (Avpr1b) is one of two principal receptors mediating the behavioral effects of vasopressin (Avp) in the brain...
  21. ncbi Attenuated stress-induced catecholamine release in mice lacking the vasopressin V1b receptor
    Shuji Itoh
    Research Institute of Pharmacological and Therapeutical Development, Otsuka Pharmaceutical, Ltd, 463 10, Kagasuno, Kawauchi cho, Tokushima 771 0192, Japan
    Am J Physiol Endocrinol Metab 291:E147-51. 2006
    ..Taken together, these findings suggest that, in addition to the previously elucidated effect on the hypothalamic-pituitary-adrenal axis, vasopressin activity via V(1b) receptors regulates stress-induced catecholamine release...
  22. pmc The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions
    Akito Tanoue
    Department of Molecular, Cell Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Clin Invest 113:302-9. 2004
    ..Among these three subtypes, the vasopressin V1b receptor is specifically expressed in pituitary corticotrophs and mediates the stimulatory effect of vasopressin ..
  23. ncbi Vasopressin V1b receptor knockout reduces aggressive behavior in male mice
    S R Wersinger
    Section on Neural Gene Expression, NIMH, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 7:975-84. 2002
    ..We suggest that V1bR antagonists could prove useful for treating aggressive behavior seen, for example, in dementias and traumatic brain injuries...
  24. doi Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag
    Yoshiaki Yamaguchi
    Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Science 342:85-90. 2013
    ....
  25. pmc Role of the vasopressin 1b receptor in rodent aggressive behavior and synaptic plasticity in hippocampal area CA2
    J H Pagani
    Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Mol Psychiatry 20:490-9. 2015
    The vasopressin 1b receptor (Avpr1b) is critical for social memory and social aggression in rodents, yet little is known about its specific roles in these behaviors...
  26. pmc Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling
    Mathew D Edwards
    Division of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 113:2732-7. 2016
    ..Specifically, Cry expression must be circadian and appropriately phased to support rhythms, and AVP receptor signaling is required to impose circuit-level circadian function. ..
  27. ncbi Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and Lewis lung carcinoma metastasis in mice
    A V Amikishieva
    Institute of Cytology and Genetics of Siberian Department of Russian Academy of Sciences, Novosibirsk, Russian Federation 630090
    Exp Oncol 33:126-9. 2011
    To study the effect of new vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and Lewis lung carcinoma metastasis in the anxious adult male mice of C57Bl/6J strain...
  28. ncbi Patch-clamp analysis of gene-targeted vomeronasal neurons expressing a defined V1r or V2r receptor: ionic mechanisms underlying persistent firing
    Kirill Ukhanov
    Whitney Laboratory for Marine Bioscience, Center for Smell and Taste, and the McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    J Neurophysiol 98:2357-69. 2007
    ..Collectively, these results suggest a novel mechanism for regulating and encoding neuronal activity in the accessory olfactory system...
  29. pmc The vasopressin Avpr1b receptor: molecular and pharmacological studies
    Ja Roper
    Henry Wellcome LINE, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK
    Stress 14:98-115. 2011
    The distribution, pharmacology and function of the arginine vasopressin (Avp) 1b receptor subtype (Avpr1b) has proved more challenging to investigate compared to other members of the Avp receptor family...
  30. doi Vasopressin regulation of blood pressure and volume: findings from V1a receptor-deficient mice
    Toshinori Aoyagi
    Department of Pharmacology, National Research Institute for Child Health and Development, Tokyo 157 8535, Japan
    Kidney Int 76:1035-9. 2009
    ..Thus, AVP regulates blood pressure and volume via V1aR by exerting diverse functions in vivo...
  31. doi Both V(1A) and V(1B) vasopressin receptors deficiency result in impaired glucose tolerance
    Kazuaki Nakamura
    Department of Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan
    Eur J Pharmacol 613:182-8. 2009
    ....
  32. doi Altered lipid metabolism in vasopressin V1B receptor-deficient mice
    Masami Hiroyama
    Department of Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan
    Eur J Pharmacol 602:455-61. 2009
    ....
  33. ncbi Body water balance and body temperature in vasopressin V1b receptor knockout mice
    R Daikoku
    Department of Physiology, Faculty of Medicine, University of Miyazaki, Miyazaki 889 1692, Japan
    Auton Neurosci 136:58-62. 2007
    ..Thus, the findings suggest that the V(1b) receptor may be, at least in part, involved in body water balance and body temperature regulation...
  34. ncbi V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Neurosci Lett 356:195-8. 2004
    In this study, we examined the performance of vasopressin V1a receptor (V1aR) and vasopressin V1b receptor (V1bR) knockout (KO) mice compared to wild-type (WT) mice in an eight-arm radial maze...
  35. ncbi Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive
    Tom R Hollon
    Molecular Neuropharmacology Section and Basic Neurosciences Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1406, USA
    J Neurosci 22:10801-10. 2002
    ....
  36. ncbi Overexpression of the V3 vasopressin receptor in transgenic mice corticotropes leads to increased basal corticosterone
    P Rene
    CNRS UPR 1524, Paris, France
    J Neuroendocrinol 14:737-44. 2002
    The vasopressin V3 receptor (V3) is specifically expressed in pituitary corticotropes and mediates the stimulatory effect of vasopressin on adrenocorticotropic hormone (ACTH) release...