Aqp7

Summary

Gene Symbol: Aqp7
Description: aquaporin 7
Alias: AQP7L, AQPap, aquaporin-7, AQP-7, aquaglyceroporin-7
Species: mouse

Top Publications

  1. ncbi Role of aquaporin water channels in kidney and lung
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0521, USA
    Am J Med Sci 316:310-20. 1998
  2. pmc The mouse follicle microenvironment regulates antrum formation and steroid production: alterations in gene expression profiles
    Erin R West-Farrell
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Biol Reprod 80:432-9. 2009
  3. ncbi Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice
    Eisei Sohara
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Am J Physiol Renal Physiol 289:F1195-200. 2005
  4. pmc Aquaporin7 plays a crucial role in tolerance to hyperosmotic stress and in the survival of oocytes during cryopreservation
    Ya Jing Tan
    Center of Reproductive Medicine, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    Sci Rep 5:17741. 2015
  5. doi Dynamic subcellular localization of aquaporin-7 in white adipocytes
    Takayuki Miyauchi
    Department of Pharmacology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan Electronic address
    FEBS Lett 589:608-14. 2015
  6. doi Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation
    Ya Jing Tan
    Key Laboratory of Reproductive Genetics Zhejiang University, Ministry of Education, Hangzhou, PR China
    Fertil Steril 99:1428-35. 2013
  7. doi Over-expression of AQP7 contributes to improve insulin resistance in adipocytes
    Fei Xia Shen
    Department of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, PR China
    Exp Cell Res 318:2377-84. 2012
  8. doi Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells
    Mariko Hara-Chikuma
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    FASEB J 26:211-8. 2012
  9. doi A new role for aquaporin 7 in insulin secretion
    Karim Louchami
    Laboratory of Experimental Hormonology, Universite Libre de Bruxelles, Brussels, Belgium
    Cell Physiol Biochem 29:65-74. 2012
  10. ncbi AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism
    Mariusz T Skowronski
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 292:F956-65. 2007

Scientific Experts

  • K Edashige
  • Said Hashemolhosseini
  • K Ishibashi
  • Alan S Verkman
  • Ching Hei Yeung
  • Eisei Sohara
  • Shinichi Uchida
  • Ya Jing Tan
  • Toshiyuki Hibuse
  • Mariko Hara-Chikuma
  • Norikazu Maeda
  • Sei Sasaki
  • Iichiro Shimomura
  • Tohru Funahashi
  • Shinji Kihara
  • Hiroshi Kuriyama
  • Takayuki Miyauchi
  • Guo Lian Ding
  • Jian zhong Sheng
  • He Feng Huang
  • Tatemitsu Rai
  • Karim Louchami
  • Fei Xia Shen
  • Chang Suk Kong
  • Søren Nielsen
  • Aleksandra Rojek
  • Hongying Peng
  • Ken Kishida
  • Olivier Devuyst
  • Tadashi Nakamura
  • Kleber S Parreira
  • Erin R West-Farrell
  • Mariusz T Skowronski
  • Kazuhiro Matsumura
  • C G Walker
  • Incheol Shin
  • Yoshihiro Tochino
  • Azumi Nagasawa
  • Yuji Matsuzawa
  • Ling Gao
  • Go J Yoshida
  • Li Jin
  • Yoichiro Abe
  • Hiroyuki Yamamoto
  • Xue Ying Zhang
  • Li Wang
  • Rong Li
  • Masato Yasui
  • Xian Hua Lin
  • Deliang Huang
  • Zijuan Liu
  • Yun Xiong
  • Ye Meng
  • Dan Zhang
  • Yoshiki Miyachi
  • Renaud Beauwens
  • Len Best
  • Wei Li
  • Shintaro Inoue
  • Emeline Hupkens
  • Wei Pan
  • Myrna Virreira
  • Willy J Malaisse
  • Jason Perret
  • Lian Song Ni
  • Abdullah Sener
  • Peter Brown
  • Yoshinori Sugiyama
  • Kenji Kabashima
  • Wei Ping Li
  • Xuemei Gu
  • K Kishida
  • Li juan Yang
  • Xue Jiang Gu
  • Christine Delporte
  • Jing Ye
  • Jung Ae Kim
  • Enkui Duan
  • Li Lei
  • Se Kwon Kim
  • Jingwen Yue
  • Qi Chen
  • Hee Guk Byun
  • Soon Sun Bak
  • Ying Zhang
  • Yi Tan
  • H Offenberg
  • Lonnie D Shea
  • Teresa K Woodruff
  • Monica A Gomberg

Detail Information

Publications34

  1. ncbi Role of aquaporin water channels in kidney and lung
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0521, USA
    Am J Med Sci 316:310-20. 1998
    ..The transgenic mouse and mammalian cell models are thus beginning to provide clues about the role of aquaporins in normal physiology and disease...
  2. pmc The mouse follicle microenvironment regulates antrum formation and steroid production: alterations in gene expression profiles
    Erin R West-Farrell
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Biol Reprod 80:432-9. 2009
    ..The expression levels of genes (Star, Cyp11a1, Cyp17a1, Hsd3b1, Cyp19a1, Fshr, Lhcgr, Aqp7, Aqp8, Aqp9, and Hif1a) were measured and correlated to follicle developmental status...
  3. ncbi Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice
    Eisei Sohara
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Am J Physiol Renal Physiol 289:F1195-200. 2005
    The aquaporin-7 (AQP7) water channel is known as a member of the aquaglyceroporins, which facilitate the transport of glycerol as well as water...
  4. pmc Aquaporin7 plays a crucial role in tolerance to hyperosmotic stress and in the survival of oocytes during cryopreservation
    Ya Jing Tan
    Center of Reproductive Medicine, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    Sci Rep 5:17741. 2015
    ..Knockdown of AQP7 expression by siRNA-injection significantly reduced the survival of oocytes after vitrification...
  5. doi Dynamic subcellular localization of aquaporin-7 in white adipocytes
    Takayuki Miyauchi
    Department of Pharmacology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan Electronic address
    FEBS Lett 589:608-14. 2015
    Aquaporin-7 (AQP7) is expressed in adipose tissue, permeated by water and glycerol, and is involved in lipid metabolism. AQP7-null mice develop obesity, insulin resistance, and adipocyte hypertrophy...
  6. doi Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation
    Ya Jing Tan
    Key Laboratory of Reproductive Genetics Zhejiang University, Ministry of Education, Hangzhou, PR China
    Fertil Steril 99:1428-35. 2013
    To investigate the effects of cryoprotectants on the expression of AQP7 in oocytes.
  7. doi Over-expression of AQP7 contributes to improve insulin resistance in adipocytes
    Fei Xia Shen
    Department of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, PR China
    Exp Cell Res 318:2377-84. 2012
    b>Aquaglyceroporin 7 (AQP7) is required for efflux of glycerol from adipocytes...
  8. doi Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells
    Mariko Hara-Chikuma
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    FASEB J 26:211-8. 2012
    ..Here we show that the water/glycerol channel protein aquaporin 7 (AQP7) is expressed on epidermal and dermal DCs and involved in the initiation of primary immune responses...
  9. doi A new role for aquaporin 7 in insulin secretion
    Karim Louchami
    Laboratory of Experimental Hormonology, Universite Libre de Bruxelles, Brussels, Belgium
    Cell Physiol Biochem 29:65-74. 2012
    BACGROUNS/AIMS: Several insulinotropic agents were recently reported to cause β-cell swelling. The possible participation of AQP7 to water transport was investigated in AQP7(+/+) or AQP7(-/-) mice.
  10. ncbi AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism
    Mariusz T Skowronski
    The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 292:F956-65. 2007
    Aquaporin (AQP7) is expressed in proximal tubules and is involved in glycerol uptake. The cellular expression and physiological function in other organs remain largely undefined...
  11. ncbi Aquaporin7 expression during perinatal development of mouse brain
    Incheol Shin
    Department of Life Science, Hanyang University, Seoul 133 791, South Korea
    Neurosci Lett 409:106-11. 2006
    ..However, the expression of AQP7, an aquaglyceroporin associated with brain development, has not been shown...
  12. ncbi Morphologic and functional analysis of sperm and testes in Aquaporin 7 knockout mice
    Eisei Sohara
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Fertil Steril 87:671-6. 2007
    To investigate the functional and morphologic role of Aquaporin 7 (AQP7) in testis and sperm.
  13. ncbi Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency
    C G Walker
    Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, London, UK
    Int J Obes (Lond) 31:1165-71. 2007
    ..receptor alpha deficiency on gene expression of adipose triglyceride lipase and the glycerol transporter aquaglyceroporin 7 in white adipose tissue in the fed and fasted states in relation to glycerol release by isolated adipocytes.
  14. pmc Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion
    Kazuhiro Matsumura
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:6026-37. 2007
    ..cells, we studied the expression of the glycerol channels, or aquaglyceroporins, encoded by the aquaporin 3 (Aqp3), Aqp7, and Aqp9 genes in mouse islets...
  15. doi Aquaporin isoforms involved in physiological volume regulation of murine spermatozoa
    Ching Hei Yeung
    Centre of Reproductive Medicine and Andrology, University of Munster, D 48129 Munster, Germany
    Biol Reprod 80:350-7. 2009
    ..b>Aqp7, Aqp8, and Aqp9 mRNAs were identified in spermatozoa by RT-PCR, and the entire open reading frames were sequenced ..
  16. doi The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator
    Toshiyuki Hibuse
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka, Japan
    Cardiovasc Res 83:34-41. 2009
    ..Several reports showed that a moderate expression of aquaporin 7 (AQP7), a member of the aquaglyceroporin family that is permeated by glycerol and water, is observed in heart ..
  17. pmc Expression patterns of the aquaporin gene family during renal development: influence of genetic variability
    Kleber S Parreira
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, 1200, Brussels, Belgium
    Pflugers Arch 458:745-59. 2009
    ....
  18. doi Anti-obesity effect of carboxymethyl chitin by AMPK and aquaporin-7 pathways in 3T3-L1 adipocytes
    Chang Suk Kong
    Department of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 617 736, Republic of Korea
    J Nutr Biochem 22:276-81. 2011
    ..These results suggest that CM-chitin exerts anti-adipogenic effect on lipid accumulation through modulations of AMPK and aquaporin-7 signal pathways...
  19. doi Aquaporin 7 expression in postimplantation mouse uteri: a potential role for glycerol transport in uterine decidualization
    Hongying Peng
    Laboratory Animal Center, Chongqing Medical University, Chongqing, People s Republic of China
    Fertil Steril 95:1514-7.e1-3. 2011
    The aquaglyceroporin aquaporin 7 (AQP7) is dynamically expressed in mouse uteri undergoing decidualization after implantation...
  20. ncbi Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping
    K Ishibashi
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Biochim Biophys Acta 1399:62-6. 1998
    ..The human AQP7 gene is identical with human adipose AQP (AQPap or AQP7L)...
  21. ncbi Channel-dependent permeation of water and glycerol in mouse morulae
    Keisuke Edashige
    Laboratory of Animal Science, College of Agriculture, Kochi University, Nankoku, Kochi 783 8502, Japan
    Biol Reprod 74:625-32. 2006
    ..In conclusion, water and glycerol appear to move across the plasma membrane mainly by simple diffusion in oocytes but by facilitated diffusion through water channel(s) including aquaporin 3 in morulae...
  22. ncbi More than just water channels: unexpected cellular roles of aquaporins
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, Room 1246, Box 0521 University of California San Francisco, San Francisco, CA 94143 0521, USA
    J Cell Sci 118:3225-32. 2005
    ..The many roles of AQPs could be exploited for clinical benefit; for example, treatments that modulate AQP expression/function could be used as diuretics, and in the treatment of brain swelling, glaucoma, epilepsy, obesity and cancer...
  23. pmc Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase
    Toshiyuki Hibuse
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 102:10993-8. 2005
    In adipocytes, hydrolysis of triglycerides results in the release of free fatty acids and glycerol. Aquaporin 7 (AQP7), a member of aquaglyceroporins, is known to permeabilize glycerol and water...
  24. ncbi Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation
    Mariko Hara-Chikuma
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 280:15493-6. 2005
    Aquaporin-7 (AQP7) is a water/glycerol transporting protein expressed in adipocyte plasma membranes. We report here remarkable age-dependent hypertrophy in adipocytes in AQP7-deficient mice...
  25. pmc Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue
    Norikazu Maeda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 101:17801-6. 2004
    ..Here, we investigated glycerol and glucose metabolism in mice lacking aquaporin 7 (Aqp7), a member of the aquaglyceroporins expressed in adipose tissue, and demonstrated that Aqp7 functions as ..
  26. ncbi Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9
    Hiroshi Kuriyama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan
    Diabetes 51:2915-21. 2002
    Plasma glycerol is a major substrate for hepatic gluconeogenesis. Aquaporin adipose (AQPap/7), an adipose-specific glycerol channel, provides fat-derived glycerol into plasma...
  27. ncbi Restricted expression of mouse GCMa/Gcm1 in kidney and thymus
    Said Hashemolhosseini
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Mech Dev 118:175-8. 2002
    ..In thymus, mGCMa is restricted to few small clusters of cells, in kidney to the S3 segment of proximal tubules. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development...
  28. ncbi Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea
    Deliang Huang
    Section on Neurobiology, Leslie and Susan Gonda Department of Cell and Molecular Biology, 2100 West Third Street, House Ear Institute, Los Angeles, CA 90057, USA
    Hear Res 165:85-95. 2002
    ..We report here that AQP3, AQP7 and AQP9 were expressed in the inner ear...
  29. pmc Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9
    Zijuan Liu
    Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Proc Natl Acad Sci U S A 99:6053-8. 2002
    ..encodes a membrane protein homologous to the bacterial aquaglyceroporin GlpF and to mammalian aquaglyceroporins AQP7 and AQP9. Fps1p mediates glycerol uptake and glycerol efflux in response to hypoosmotic shock...
  30. ncbi Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel
    K Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita 565 0871, Japan
    J Biol Chem 276:36251-60. 2001
    Aquaporin adipose (AQPap) is a putative glycerol channel in adipocytes (Kishida, K., Kuriyama, H., Funahashi, T., Shimomura, I., Kihara, S., Ouchi, N., Nishida, M., Nishizawa, H., Matsuda, M., Takahashi, M., Hotta, K., Nakamura, T...
  31. ncbi mRNAs encoding aquaporins are present during murine preimplantation development
    H Offenberg
    Department of Clinical Studies, Reproduction, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Mol Reprod Dev 57:323-30. 2000
    ..These findings predict that AQPs may function as conduits for trophectoderm fluid transport during blastocyst formation...
  32. ncbi Expression of mRNAs of the aquaporin family in mouse oocytes and embryos
    K Edashige
    Laboratory of Animal Science, College of Agriculture, Kochi University, Nankoku, Kochi, 783 8502, Japan
    Cryobiology 40:171-5. 2000
    ..These aquaporins may play a role in water transport and conceivably also in cryoprotectant transport across the plasma membrane in these cells...
  33. ncbi Lessons on renal physiology from transgenic mice lacking aquaporin water channels
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0521, USA
    J Am Soc Nephrol 10:1126-35. 1999
    ..descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the collecting duct; AQP6 in the papilla; and AQP7 in the proximal tubule...
  34. ncbi Aquaporin molecular biology and clinical abnormalities of the water transport channels
    N V Knoers
    Department of Human Genetics, University Hospital Nijmegen, The Netherlands
    Curr Opin Pediatr 10:428-34. 1998
    ..The finding of changed AQP2 expression in several acquired water balance disorders may pave the way toward developing treatments for these clinical problems...